County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions,and it influences many aspects of wider economic and social development.In...County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions,and it influences many aspects of wider economic and social development.In China’s modernisation process,they have always played a vital role.The 2024 Central Economic Work Conference placed strong emphasis on vigorously developing county economies.展开更多
Amino acids are the building blocks of proteins and play vital roles in both biological systems and drug development.In recent years,increasing attention has been given to the functionalization of amino acid derivativ...Amino acids are the building blocks of proteins and play vital roles in both biological systems and drug development.In recent years,increasing attention has been given to the functionalization of amino acid derivatives.Since the introduction of therapeutic insulin in the early 20th century,the conjugation of drug molecules with amino acids and peptides has been pivotal in driving advancements in drug discovery and become an integral part of modern medical practice.Currently,over a hundred peptide-drug conjugates have received global approval and are widely used to treat diseases such as diabetes,cancer,chronic pain,and multiple sclerosis.Key technologies for conjugating peptides with bioactive molecules include antibody-drug conjugates(ADCs),peptide-drug conjugates(PDCs),and proteolysis targeting chimeras(PROTACs).Significant efforts have been dedicated to developing strategies for the modification of amino acids and peptides,with particular focus on site-selective C-H alkylation/arylation reactions.These reactions are crucial for synthesizing bioactive molecules,as they enable the precise introduction of functional groups at specific positions,thereby improving the pharmacological properties of the resulting compounds.展开更多
The African Geoparks Network(AGN)was initiated by the African Association of Women in Geosciences(AAWG)during its fifth pre-conference meeting in Abidjan,Ivory Coast in May 2009.The AGN aims to identify,promote,and ad...The African Geoparks Network(AGN)was initiated by the African Association of Women in Geosciences(AAWG)during its fifth pre-conference meeting in Abidjan,Ivory Coast in May 2009.The AGN aims to identify,promote,and advise on the importance of the valorization and the preservation of African geoheritage for local sustainable development.In that framework,the AAWG and the AGN in collaboration with UNESCO Cairo Office are organizing the First International Conference on African and Arabian Geoparks from the 20th to the 28th November 2011 in El Jadida(Morocco).展开更多
文摘County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions,and it influences many aspects of wider economic and social development.In China’s modernisation process,they have always played a vital role.The 2024 Central Economic Work Conference placed strong emphasis on vigorously developing county economies.
文摘Amino acids are the building blocks of proteins and play vital roles in both biological systems and drug development.In recent years,increasing attention has been given to the functionalization of amino acid derivatives.Since the introduction of therapeutic insulin in the early 20th century,the conjugation of drug molecules with amino acids and peptides has been pivotal in driving advancements in drug discovery and become an integral part of modern medical practice.Currently,over a hundred peptide-drug conjugates have received global approval and are widely used to treat diseases such as diabetes,cancer,chronic pain,and multiple sclerosis.Key technologies for conjugating peptides with bioactive molecules include antibody-drug conjugates(ADCs),peptide-drug conjugates(PDCs),and proteolysis targeting chimeras(PROTACs).Significant efforts have been dedicated to developing strategies for the modification of amino acids and peptides,with particular focus on site-selective C-H alkylation/arylation reactions.These reactions are crucial for synthesizing bioactive molecules,as they enable the precise introduction of functional groups at specific positions,thereby improving the pharmacological properties of the resulting compounds.
文摘The African Geoparks Network(AGN)was initiated by the African Association of Women in Geosciences(AAWG)during its fifth pre-conference meeting in Abidjan,Ivory Coast in May 2009.The AGN aims to identify,promote,and advise on the importance of the valorization and the preservation of African geoheritage for local sustainable development.In that framework,the AAWG and the AGN in collaboration with UNESCO Cairo Office are organizing the First International Conference on African and Arabian Geoparks from the 20th to the 28th November 2011 in El Jadida(Morocco).
