County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions and,in turn,influences many aspects of wider economic and social developme...County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions and,in turn,influences many aspects of wider economic and social development.In China's modernization process,they have always played a vital role.The 2024 Central Economic Work Conference placed strong emphasis on vigorously developing county economies.展开更多
Amino acids are the building blocks of proteins and play vital roles in both biological systems and drug development.In recent years,increasing attention has been given to the functionalization of amino acid derivativ...Amino acids are the building blocks of proteins and play vital roles in both biological systems and drug development.In recent years,increasing attention has been given to the functionalization of amino acid derivatives.Since the introduction of therapeutic insulin in the early 20th century,the conjugation of drug molecules with amino acids and peptides has been pivotal in driving advancements in drug discovery and become an integral part of modern medical practice.Currently,over a hundred peptide-drug conjugates have received global approval and are widely used to treat diseases such as diabetes,cancer,chronic pain,and multiple sclerosis.Key technologies for conjugating peptides with bioactive molecules include antibody-drug conjugates(ADCs),peptide-drug conjugates(PDCs),and proteolysis targeting chimeras(PROTACs).Significant efforts have been dedicated to developing strategies for the modification of amino acids and peptides,with particular focus on site-selective C-H alkylation/arylation reactions.These reactions are crucial for synthesizing bioactive molecules,as they enable the precise introduction of functional groups at specific positions,thereby improving the pharmacological properties of the resulting compounds.展开更多
County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions,and it influences many aspects of wider economic and social development.In...County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions,and it influences many aspects of wider economic and social development.In China’s modernisation process,they have always played a vital role.The 2024 Central Economic Work Conference placed strong emphasis on vigorously developing county economies.展开更多
The Outline of Women's Development in China(2021-2030)has proposed goals and supportive measures,to promote women's employment and entrepreneurship,and to guarantee equal rights and opportunities for women to ...The Outline of Women's Development in China(2021-2030)has proposed goals and supportive measures,to promote women's employment and entrepreneurship,and to guarantee equal rights and opportunities for women to participate in economic development.In the process of promoting high-quality economic development,China is upholding employment as a priority.展开更多
The coronavirus disease 2019(COVID-19)pandemic has stimulated extensive endeavors toward the development of therapeutic interventions targeting severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and human prot...The coronavirus disease 2019(COVID-19)pandemic has stimulated extensive endeavors toward the development of therapeutic interventions targeting severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and human proteins for viral infection control,encompassing numerous potential drugs and thousands of patients participating in clinical trials.These concerted efforts have resulted in significant advancements in antiviral drug discovery and development.In this review,we present a comprehensive timeline detailing the development of antiviral drugs,tracing the progression from early viral inhibitors to modern broad-spectrum antiviral agents.We also outline the current status of advancements in antiviral drug discovery,encompassing target-based strategies,innovative mechanism-based approaches,and pharmacokinetic optimization.Furthermore,we discuss the challenges and future prospects gained from COVID-19 and other infectious diseases,covering knowledge of artificial intelligence strategies,the utilization of medicinal chemistry tools,and advancements in nanotechnology applications.The application of artificial intelligence in drug discovery is increasingly prevalent,particularly in the areas of protein structure prediction,drug target identification,and bioactivity forecasting.Nanotechnology has played a crucial role in the delivery of antiviral drugs and the development of vaccines,exemplified by the use of lipid nanoparticles in mRNA vaccines.Additionally,we highlight potential future directions for drug discovery,such as targeting membraneless organelles(liquid‒liquid phase separation).展开更多
The design of highly active photocatalysts for carbon dioxide reduction is of far-reaching significance for the mitigation of industrial exhaust pollution and the promotion of sustainable development.In this work,thre...The design of highly active photocatalysts for carbon dioxide reduction is of far-reaching significance for the mitigation of industrial exhaust pollution and the promotion of sustainable development.In this work,three catalysts containing dual ligands and doped with metal V,[Co(DAPSC)(H_(2)O)_(2)]_(2)[Co(H_(2)O)_(5)]_(0.5)[PW_(11)CoO_(39)(Hdatrz)]·3.5H_(2)O(1),(H_(2)bim)[Co(DAPSC)(bim)(H_(3)PW_(10)V_(2)^(Ⅳ)O_(40))]·4H_(2)O(2),and[Co(DAPSC)(bbi)(H_(2)O)]_(2)(PW_(11.5)V_(0:5)^(Ⅳ)O_(40))·4H_(2)O(3)[DAPSC=2,6-diacetylpyridine bis-(semicarbazone),Hdatrz=3,5-diamino-1,2,4-triazole,bim=bis(1-imidazolyl)methane,and bbi=1,1’-(1,4-butanediyl)bis(imidazole)],have been successfully synthesized under hydrothermal conditions.A systematic exploration was undertaken to characterise the structures and photocatalytic transformations.The results of both the IR and EDS tests indicated the successful doping of V atoms.The photocatalytic CO_(2)reduction exploration demonstrated that all catalysts modified with dual ligands exhibited high photocatalytic activity.The results therein revealed that catalyst 2 exhibited the most efficient photocatalytic performance in the reduction of carbon dioxide using visible light.Under optimal conditions,the CO yield reached 11003.3μmol g^(−1)h^(−1)and maintained good catalytic activity after five cycles,outperforming the majority of the reported heterogeneous POM-based photocatalysts.The present study proves that the additional doping of the transition metal vanadium into catalysts based on dual ligands downstream contributes to the development of highly active photocatalysts for CO_(2)reduction.展开更多
The African Geoparks Network(AGN)was initiated by the African Association of Women in Geosciences(AAWG)during its fifth pre-conference meeting in Abidjan,Ivory Coast in May 2009.The AGN aims to identify,promote,and ad...The African Geoparks Network(AGN)was initiated by the African Association of Women in Geosciences(AAWG)during its fifth pre-conference meeting in Abidjan,Ivory Coast in May 2009.The AGN aims to identify,promote,and advise on the importance of the valorization and the preservation of African geoheritage for local sustainable development.In that framework,the AAWG and the AGN in collaboration with UNESCO Cairo Office are organizing the First International Conference on African and Arabian Geoparks from the 20th to the 28th November 2011 in El Jadida(Morocco).展开更多
文摘County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions and,in turn,influences many aspects of wider economic and social development.In China's modernization process,they have always played a vital role.The 2024 Central Economic Work Conference placed strong emphasis on vigorously developing county economies.
文摘Amino acids are the building blocks of proteins and play vital roles in both biological systems and drug development.In recent years,increasing attention has been given to the functionalization of amino acid derivatives.Since the introduction of therapeutic insulin in the early 20th century,the conjugation of drug molecules with amino acids and peptides has been pivotal in driving advancements in drug discovery and become an integral part of modern medical practice.Currently,over a hundred peptide-drug conjugates have received global approval and are widely used to treat diseases such as diabetes,cancer,chronic pain,and multiple sclerosis.Key technologies for conjugating peptides with bioactive molecules include antibody-drug conjugates(ADCs),peptide-drug conjugates(PDCs),and proteolysis targeting chimeras(PROTACs).Significant efforts have been dedicated to developing strategies for the modification of amino acids and peptides,with particular focus on site-selective C-H alkylation/arylation reactions.These reactions are crucial for synthesizing bioactive molecules,as they enable the precise introduction of functional groups at specific positions,thereby improving the pharmacological properties of the resulting compounds.
文摘County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions,and it influences many aspects of wider economic and social development.In China’s modernisation process,they have always played a vital role.The 2024 Central Economic Work Conference placed strong emphasis on vigorously developing county economies.
文摘The Outline of Women's Development in China(2021-2030)has proposed goals and supportive measures,to promote women's employment and entrepreneurship,and to guarantee equal rights and opportunities for women to participate in economic development.In the process of promoting high-quality economic development,China is upholding employment as a priority.
基金financial support from the National Natural Science Foundation of China(Nos.22208191,22273049)the Key Research and Development Program,Ministry of Science and Technology of the People’s Republic of China(Grant No.2023YFC2606500)+4 种基金the National Key R&D Program of China(No.2022YFA1503102)the Major Basic Research Project of Shandong Provincial Natural Science Foundation(ZR2021ZD17)the Guangdong Basic and Applied Basic Research Foundation(2021A1515110740)the Shandong Laboratory Program(SYS202205)also supported by the Korea Health Industry Development Institute(KHIDI)funded by the Ministry of Health&Welfare,Republic of Korea(HI22C2067).
文摘The coronavirus disease 2019(COVID-19)pandemic has stimulated extensive endeavors toward the development of therapeutic interventions targeting severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and human proteins for viral infection control,encompassing numerous potential drugs and thousands of patients participating in clinical trials.These concerted efforts have resulted in significant advancements in antiviral drug discovery and development.In this review,we present a comprehensive timeline detailing the development of antiviral drugs,tracing the progression from early viral inhibitors to modern broad-spectrum antiviral agents.We also outline the current status of advancements in antiviral drug discovery,encompassing target-based strategies,innovative mechanism-based approaches,and pharmacokinetic optimization.Furthermore,we discuss the challenges and future prospects gained from COVID-19 and other infectious diseases,covering knowledge of artificial intelligence strategies,the utilization of medicinal chemistry tools,and advancements in nanotechnology applications.The application of artificial intelligence in drug discovery is increasingly prevalent,particularly in the areas of protein structure prediction,drug target identification,and bioactivity forecasting.Nanotechnology has played a crucial role in the delivery of antiviral drugs and the development of vaccines,exemplified by the use of lipid nanoparticles in mRNA vaccines.Additionally,we highlight potential future directions for drug discovery,such as targeting membraneless organelles(liquid‒liquid phase separation).
基金supported by the Natural Science Foundation of China(92161109)the Cultivation Program for the Excellent Doctoral Dissertation of Nanjing Tech University(2023-10).
文摘The design of highly active photocatalysts for carbon dioxide reduction is of far-reaching significance for the mitigation of industrial exhaust pollution and the promotion of sustainable development.In this work,three catalysts containing dual ligands and doped with metal V,[Co(DAPSC)(H_(2)O)_(2)]_(2)[Co(H_(2)O)_(5)]_(0.5)[PW_(11)CoO_(39)(Hdatrz)]·3.5H_(2)O(1),(H_(2)bim)[Co(DAPSC)(bim)(H_(3)PW_(10)V_(2)^(Ⅳ)O_(40))]·4H_(2)O(2),and[Co(DAPSC)(bbi)(H_(2)O)]_(2)(PW_(11.5)V_(0:5)^(Ⅳ)O_(40))·4H_(2)O(3)[DAPSC=2,6-diacetylpyridine bis-(semicarbazone),Hdatrz=3,5-diamino-1,2,4-triazole,bim=bis(1-imidazolyl)methane,and bbi=1,1’-(1,4-butanediyl)bis(imidazole)],have been successfully synthesized under hydrothermal conditions.A systematic exploration was undertaken to characterise the structures and photocatalytic transformations.The results of both the IR and EDS tests indicated the successful doping of V atoms.The photocatalytic CO_(2)reduction exploration demonstrated that all catalysts modified with dual ligands exhibited high photocatalytic activity.The results therein revealed that catalyst 2 exhibited the most efficient photocatalytic performance in the reduction of carbon dioxide using visible light.Under optimal conditions,the CO yield reached 11003.3μmol g^(−1)h^(−1)and maintained good catalytic activity after five cycles,outperforming the majority of the reported heterogeneous POM-based photocatalysts.The present study proves that the additional doping of the transition metal vanadium into catalysts based on dual ligands downstream contributes to the development of highly active photocatalysts for CO_(2)reduction.
文摘The African Geoparks Network(AGN)was initiated by the African Association of Women in Geosciences(AAWG)during its fifth pre-conference meeting in Abidjan,Ivory Coast in May 2009.The AGN aims to identify,promote,and advise on the importance of the valorization and the preservation of African geoheritage for local sustainable development.In that framework,the AAWG and the AGN in collaboration with UNESCO Cairo Office are organizing the First International Conference on African and Arabian Geoparks from the 20th to the 28th November 2011 in El Jadida(Morocco).
