The field of Neurorestoratology is steadily growing.The developmental phases and current key tasks are presented below:Neurorestoratology development divides into four phases,Preparation,Incubation,Growth,and Maturity...The field of Neurorestoratology is steadily growing.The developmental phases and current key tasks are presented below:Neurorestoratology development divides into four phases,Preparation,Incubation,Growth,and Maturity.1 The characteristics of the Preparation phase.展开更多
Alzheimer＇s disease （AD） is the most frequent cause of dementia in the western world. In clinical terms, AD is characterized by progres- sive cognitive decline that usually begins with memory impairment. As the dis...Alzheimer＇s disease （AD） is the most frequent cause of dementia in the western world. In clinical terms, AD is characterized by progres- sive cognitive decline that usually begins with memory impairment. As the disease progresses, AD inevitably affects all intellectual functions including executive functions, leading to complete dependence for basic activities of daily life and premature death.展开更多
CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role...CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.展开更多
Interdisciplinary research plays a crucial role in addressing complex problems by integrating knowledge from multiple disciplines.This integration fosters innovative solutions and enhances understanding across various...Interdisciplinary research plays a crucial role in addressing complex problems by integrating knowledge from multiple disciplines.This integration fosters innovative solutions and enhances understanding across various fields.This study explores the historical and sociological development of interdisciplinary research and maps its evolution through three distinct phases:pre-disciplinary,disciplinary,and post-disciplinary.It identifies key internal dynamics,such as disciplinary diversification,reorganization,and innovation,as primary drivers of this evolution.Additionally,this study highlights how external factors,particularly the urgency of World War II and the subsequent political and economic changes,have accelerated its advancement.The rise of interdisciplinary research has significantly reshaped traditional educational paradigms,promoting its integration across different educational levels.However,the inherent contradictions within interdisciplinary research present cognitive,emotional,and institutional challenges for researchers.Meanwhile,finding a balance between the breadth and depth of knowledge remains a critical challenge in interdisciplinary education.展开更多
Logic in Bon Religion is one of the important elements in the Logic popular in Xizang.This article based on a discussion of the development of Logic and the important literatures of Bon Religion,the process of and tim...Logic in Bon Religion is one of the important elements in the Logic popular in Xizang.This article based on a discussion of the development of Logic and the important literatures of Bon Religion,the process of and time phases of studying Logic of Bon Religion,describes four important characteristics of Logic of Bon Religion.Namely,there are similarities and differences between the Logic of Buddhism and that of Bon Religion first of all.Secondly,Logic of Bon Religion bears an invaluable tradition of traditional Tibetan culture regardless from the perspective of Logic,Philosophy,the literary works conducted by the respective scholars.Thirdly,like the other sciences,the development of Logic of Bon Religion experienced a process of from uncomplete to completion,from an independent subject to a science with various disciplines.Fourthly,Logic of Bon Religion is an academic field with a strong validity.展开更多
We evaluated the phenology and litterfall dynamics of the mangrove Bruguiera gymnorrhiza（L.）Lamk along the Okukubi River, Okinawa Island, Japan.Over 3 years, this species showed the highest litterfall of leaves and ...We evaluated the phenology and litterfall dynamics of the mangrove Bruguiera gymnorrhiza（L.）Lamk along the Okukubi River, Okinawa Island, Japan.Over 3 years, this species showed the highest litterfall of leaves and stipules in summer and the lowest litterfall in winter. From Kendall＇s coefficient of concordance, the monthly changes in leaf, stipule, and branch were strongly and significantly concordant among years. Leaf and stipule litterfall could be governed by monthly maximum wind speed, monthly day length, and monthly mean air temperature. Branch litterfall depended on monthly maximum wind speed and monthly rainfall, and increased exponentially with increasing monthly maximum wind speed. Mean total litterfall was 11.8 Mg ha^（-1）yr^（-1）, with the largest component being leaf litterfall（65.8 %）. Annual leaf litterfall per plot was almost constant regardless of the tree density of the plot. Mean leaf longevity was 18 months.Flower and mature propagule litterfall might be influenced by monthly mean air temperature, monthly day length and monthly mean air temperature. The average development periods from flower buds to flowers and flower buds to mature propagules were 1 and 8 months, respectively.Except for leaf and branch, all vegetative and reproductive organ litterfall had clear annual cycles. B. gymnorrhiza showed a positive correlation between leaf production and reproductive organ production.展开更多
The research reviewed the development trend of vertical greening industry and divided it into four stages as follows： demand exploring phase, theory and technology development and application phases, and ripening pha...The research reviewed the development trend of vertical greening industry and divided it into four stages as follows： demand exploring phase, theory and technology development and application phases, and ripening phase of vertical greening system. The characteristics in different phases were detailed, providing ref- erences for development of vertical greening industry in future.展开更多
文摘The field of Neurorestoratology is steadily growing.The developmental phases and current key tasks are presented below:Neurorestoratology development divides into four phases,Preparation,Incubation,Growth,and Maturity.1 The characteristics of the Preparation phase.
文摘Alzheimer＇s disease （AD） is the most frequent cause of dementia in the western world. In clinical terms, AD is characterized by progres- sive cognitive decline that usually begins with memory impairment. As the disease progresses, AD inevitably affects all intellectual functions including executive functions, leading to complete dependence for basic activities of daily life and premature death.
文摘CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.
基金funded by the National Natural Science Foundation of China for Young Scholars(No.72304019)Peking University Health Science Center Project(No.2023YB46)+1 种基金the National Natural Science Foundation of China for Special Purpose(No.J2124013)the ISTIC-Clarivate Joint Laboratory for Scientometrics(No.IT2319).
文摘Interdisciplinary research plays a crucial role in addressing complex problems by integrating knowledge from multiple disciplines.This integration fosters innovative solutions and enhances understanding across various fields.This study explores the historical and sociological development of interdisciplinary research and maps its evolution through three distinct phases:pre-disciplinary,disciplinary,and post-disciplinary.It identifies key internal dynamics,such as disciplinary diversification,reorganization,and innovation,as primary drivers of this evolution.Additionally,this study highlights how external factors,particularly the urgency of World War II and the subsequent political and economic changes,have accelerated its advancement.The rise of interdisciplinary research has significantly reshaped traditional educational paradigms,promoting its integration across different educational levels.However,the inherent contradictions within interdisciplinary research present cognitive,emotional,and institutional challenges for researchers.Meanwhile,finding a balance between the breadth and depth of knowledge remains a critical challenge in interdisciplinary education.
文摘Logic in Bon Religion is one of the important elements in the Logic popular in Xizang.This article based on a discussion of the development of Logic and the important literatures of Bon Religion,the process of and time phases of studying Logic of Bon Religion,describes four important characteristics of Logic of Bon Religion.Namely,there are similarities and differences between the Logic of Buddhism and that of Bon Religion first of all.Secondly,Logic of Bon Religion bears an invaluable tradition of traditional Tibetan culture regardless from the perspective of Logic,Philosophy,the literary works conducted by the respective scholars.Thirdly,like the other sciences,the development of Logic of Bon Religion experienced a process of from uncomplete to completion,from an independent subject to a science with various disciplines.Fourthly,Logic of Bon Religion is an academic field with a strong validity.
基金supported by a Grant-in-Aid for Scientific Research(No.23380094)from the Ministry of Education,Culture,Sport,Science and Technology,Japan
文摘We evaluated the phenology and litterfall dynamics of the mangrove Bruguiera gymnorrhiza（L.）Lamk along the Okukubi River, Okinawa Island, Japan.Over 3 years, this species showed the highest litterfall of leaves and stipules in summer and the lowest litterfall in winter. From Kendall＇s coefficient of concordance, the monthly changes in leaf, stipule, and branch were strongly and significantly concordant among years. Leaf and stipule litterfall could be governed by monthly maximum wind speed, monthly day length, and monthly mean air temperature. Branch litterfall depended on monthly maximum wind speed and monthly rainfall, and increased exponentially with increasing monthly maximum wind speed. Mean total litterfall was 11.8 Mg ha^（-1）yr^（-1）, with the largest component being leaf litterfall（65.8 %）. Annual leaf litterfall per plot was almost constant regardless of the tree density of the plot. Mean leaf longevity was 18 months.Flower and mature propagule litterfall might be influenced by monthly mean air temperature, monthly day length and monthly mean air temperature. The average development periods from flower buds to flowers and flower buds to mature propagules were 1 and 8 months, respectively.Except for leaf and branch, all vegetative and reproductive organ litterfall had clear annual cycles. B. gymnorrhiza showed a positive correlation between leaf production and reproductive organ production.
基金Supported by Shenzhen Urban Management Science Research Fund(201208-1)~~
文摘The research reviewed the development trend of vertical greening industry and divided it into four stages as follows： demand exploring phase, theory and technology development and application phases, and ripening phase of vertical greening system. The characteristics in different phases were detailed, providing ref- erences for development of vertical greening industry in future.
