Considering some advantages of Rana nigromaculata as an experimental species, we propose that this species, like Xenopus laevis, could be used to assay thyroid hormone（TH） signaling disrupting actions. To validate t...Considering some advantages of Rana nigromaculata as an experimental species, we propose that this species, like Xenopus laevis, could be used to assay thyroid hormone（TH） signaling disrupting actions. To validate the utilizability of R. nigromaculata, we investigated the responsiveness of R. nigromaculata to a TH receptor（TR） agonist（T3） and antagonist（amiodarone） by analyzing expression, based on characterizing TR cDNA and developmental expression patterns. With high levels of identity with the corresponding genes in X. laevis, both TRα and TRβ in R. nigromaculata exhibited roughly similar developmental expression patterns to those of X. laevis, in spite of some species-specific differences. Both TRα and TRβ expression had greater changes in the liver and intestine than in the tail and brain during metamorphosis. T3 exposure for 2 days induced more dramatic increases of TRβ expression in stage 27 than in stage34 tadpoles but not in stage 42 tadpoles, showing that the responsiveness of R. nigromaculata to TH decreased with development and disappeared at the onset of metamorphic climax.Corresponding to greater changes of TRβ expression in the liver and intestine than in the tail and brain during metamorphosis, the liver and intestine had higher responsiveness to exogenous T3 than the tail and brain. Amiodarone inhibited T3-induced TRβ expression. Our results show that R. nigromaculata can be used as a model species for assaying TH signaling disrupting actions by analyzing TRβ expression, and intestine tissues at stage 27 are ideal test materials due to high responsiveness and easy accessibility.展开更多
China has achieved the poverty reduction goal of the United Nations 2030 Agenda for Sustainable Development 10 years ahead of schedule,contributing significantly to global poverty reduction.Despite extended efforts in...China has achieved the poverty reduction goal of the United Nations 2030 Agenda for Sustainable Development 10 years ahead of schedule,contributing significantly to global poverty reduction.Despite extended efforts in poverty elimination,there is a lack of quantitative studies categorizing and comparing poverty-elimination counties(PECs)based on their processes.This study proposes an innovative framework for analyzing PECs’development paths from the perspective of population-land-industry(PLI).We quantify the PLI matching degree of PECs in China during the critical phase of the battle against poverty through a multivariate matching model,classify PECs via K-means clustering according to the consistency in PLI matching degree evolution,and summarize the typical development patterns of PECs.Results indicate that the PLI matching degree of PECs in China increased substantially from 2015 to 2020,particularly in eastern areas,while the western region,including the Qinghai-Xizang Plateau and southwestern Xinjiang,shows untapped potential for improvement.Five types of PECs are identified,with the majority(30.1%)showing sustained moderate PLI matching and a minority(9.6%)experiencing long-term PLI mismatch.Industry is the shortfall of various PECs,and effective strategies to facilitate all types of PECs include the development of emerging businesses and the expansion of secondary and tertiary industries.Additionally,enriching rural labor force and increasing farmland use efficiency are essential for optimal PLI matching and positive interaction,ultimately ensuring poverty elimination and sustainable development.展开更多
China is one of the countries with the longest history in the world.The protection and development of historical and cultural resources is an issue worthy of attention in the fields of economic geography and urban-rur...China is one of the countries with the longest history in the world.The protection and development of historical and cultural resources is an issue worthy of attention in the fields of economic geography and urban-rural planning at the present stage.This study takes the Zhongyuan Urban Agglomeration,which is rich in historical and cultural heritage,as a specific case,analyzes the characteristics of the spatial-temporal distribution pattern of its historical and cultural resources.The results show that the distribution structure of historical and cultural element resources within the Zhongyuan Urban Agglomeration presents significant regional agglomeration and combination characteristics.In response to the analysis results,the study formulates an optimization strategy for the regional development pattern supported by the protection and development of historical and cultural resources,and initially proposes a matching spatial development pattern plan and policy recommendations for coordinated development.展开更多
The oxytocin receptor(OXTR)has garnered increasing attention for its role in regulating both mature behaviors and brain development.It has been established that OXTR mediates a range of effects that are regionspecifc ...The oxytocin receptor(OXTR)has garnered increasing attention for its role in regulating both mature behaviors and brain development.It has been established that OXTR mediates a range of effects that are regionspecifc or period-specifc.However,the current studies of OXTR expression patterns in mice only provide limited help due to limitations in resolution.Therefore,our objective was to generate a comprehensive,high-resolution spatiotemporal expression map of Oxtr mRNA across the entire developing mouse brain.We applied RNAscope in situ hybridization to investigate the spatiotemporal expression pattern of Oxtr in the brains of male mice at six distinct postnatal developmental stages(P7,P14,P21,P28,P42,P56).We provide detailed descriptions of Oxtr expression patterns in key brain regions,including the cortex,basal forebrain,hippocampus,and amygdaloid complex,with a focus on the precise localization of Oxtr+cells and the variance of expression between diferent neurons.Furthermore,we identifed some neuronal populations with high Oxtr expression levels that have been little studied,including glutamatergic neurons in the ventral dentate gyrus,Vgat+Oxtr+cells in the basal forebrain,and GABAergic neurons in layers 4/5 of the cortex.Our study provides a novel perspective for understanding the distribution of Oxtr and encourages further investigations into its functions.展开更多
The study profiles and explains the significant changes that have taken place in China's spatial development patterns since the inception of its economic reform and opening two decades ago. Principal component an...The study profiles and explains the significant changes that have taken place in China's spatial development patterns since the inception of its economic reform and opening two decades ago. Principal component analysis is used to delineate spatial patterns. The analyses show that prior to the reform China's spatial development pattern was characterized by the dominance of the three municipalities and the Northeast, as well as by both the coast-interior and the north-south disparities. Northern provinces were generally more industrialized and economically powerful than the southern ones. After two decades of reform, regional development has become multi-centered with South China, the Yangtze Delta and the Beijing-Tianjin area being the three most important regions of the country. The coastal provinces as a whole rose to prominence on China's economic map while the Northeast has diminished its clout. The coast-interior gap not only remains but may have widened. The north-south disparity also still exists but there has been a role reversal with the south now in the lead position. Virtually all inland provinces now find themselves at or near the low end of the development spectrum. We argue that the major reason for the recent shifts in Chinese space economy is the spatially differentiated economic growth resulted from the reform and open door policy and from the new, uneven development strategy adopted by the Chinese government. The paper discusses four specific factors that have reshaped China's spatial development patterns.展开更多
Based on the latest approach for measuring technology content of import of services and with the contribution of total factor productivity(TFP) to gross industrial output as the indicator for measuring the growth patt...Based on the latest approach for measuring technology content of import of services and with the contribution of total factor productivity(TFP) to gross industrial output as the indicator for measuring the growth pattern of China's industrial economy,this paper provides an empirical study on the effect of import technology content of trade in services on the development pattern of China's industrial economy between 2004 and2011.Result of econometric test reveals that the technology content of import of services has a significant positive effect on transforming the growth pattern of China's industrial economy.Moreover,import of new types of trade in services with high technology such as computer and information services has a much stronger positive effect compared with import of traditional trade in services with relatively low technology content such as transport.In terms of different industrial sectors,technology content of import of services has the greatest effect on transforming the development pattern of China's technologyintensive industrial sectors,followed by capital-intensive,resource-intensive and laborintensive sectors respectively.Transformation of the development pattern of China's industrial economy cannot be isolated from the system of global division of work.Against the backdrop of global service sector fragmentation,China should take the important opportunities in the development of global trade in services and give more attention to improving the quality of import of services in the interest of transforming the development pattern of its industrial economy.展开更多
In 2022,Yellow Sea green tide caused by Ulva prolifera reached a historic minimum and the coastal areas of Shandong Peninsula were less affected.However,the largest amount of seaweed biomass has been washed ashore on ...In 2022,Yellow Sea green tide caused by Ulva prolifera reached a historic minimum and the coastal areas of Shandong Peninsula were less affected.However,the largest amount of seaweed biomass has been washed ashore on Lianyungang and Rizhao coasts since 2015.We studied the development pattern of Yellow Sea green tide in 2022,and analyzed the key environmental factors on the growth and drifting,then discussed the possible reasons that resulted in the massive stranding of green tide biomass in Lianyungang and Rizhao.Results show under the combined influence of the east to southeast winds and currents with shoreward anomalies,green tide drifted to the coastal waters between Shandong and Jiangsu provinces and the distribution areas located westward compared with previous years(2008–2021).Floating U.prolifera rafts from the coastal waters of Binhai and Sheyang drifted continuously into the coastal waters of Lianyungang and Rizhao,providing important supplements for Yellow Sea green tide.Because green tide in 2022 distributed close to the coastal waters,the abundant nutrients might support their continuous high growth rate.In addition,the amount of rainfall around Shandong Peninsula from late June to early July were significantly higher than in previous years,which might promote the development of green tide to some extent.展开更多
When analyzing the Chinese economy,one should not merely focus on surface phenomena,or be confined by a purely economic,partial,or static standpoint.Contrarily,we should uphold the stances and methodologies of Xi Jinp...When analyzing the Chinese economy,one should not merely focus on surface phenomena,or be confined by a purely economic,partial,or static standpoint.Contrarily,we should uphold the stances and methodologies of Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era to get a clear picture of the current state,future direction,overarching strategies,and specific approaches of the Chinese economy in the context of the long-term evolution of the global economic system and China's endeavors of building a great modern socialist country.Since the launch of reform and opening up in 1978,China has effectively modernized itself through economic development.Par ticularly,in the f irst decade of the new era,China laid down rock-solid foundations and expanded vast spaces for future economic development through systematic modernization.With the advent of the post-COVID-19 era,the Chinese economy has entered a phase of great transition,and the country has set a goal of achieving high-quality development through a new development patter n in three critical decades.This will be unprecedented in China's economic history,and its significance and implications for the global economic system will also be unseen.China's strengths in terms of system,supply,demand,and talent provide important guarantees for a successful economic transition.During the transition period,China will look economic competition squarely,continuing to deepen its opening up and reform.The Chinese economy is expected to stabilize and accumulate momentum in the short term,gradually lift off in the medium term,and have a bright future in the long term.To bring that bright future into reality,China needs to strike a good balance between two“great miracles,”two“new patterns,”two“major blocs,”and two“world orders.”Further capacity building is needed to strengthen the Communist Party of China,enhance scientific and technological innovation,build China into a financial powerhouse,cultivate good relationships worldwide,and uphold national security while creating the conditions for ensuring it.展开更多
Global industrial chains(GICs)have become a hallmark of the world economy underpinning the global production cycle.Since the reform and opening up was introduced in 1978,China has taken an active role in global value ...Global industrial chains(GICs)have become a hallmark of the world economy underpinning the global production cycle.Since the reform and opening up was introduced in 1978,China has taken an active role in global value chains(GVCs)and become the world’s factory floor.Under the external shocks to GICs,such as US trade frictions with China and the COVID-19 pandemic,China’s traditional comparative advantages in manufacturing which include its labor force and costs are waning.This has manifested in a wave of industrial relocations from China to other countries as well as China’s weakening international competitiveness.We took stock of the concepts and journey of GVCs and elaborated the intrinsic relationship between GVCs and the new development pattern of“dual circulations”.We also analyzed the trends of GVCs,the current status and problems of China’s industrial chains,and China’s market heft,complete industrial chains and the digital economy as new strengths for industrial chain upgrade.In our conclusion,this paper put forth some policy recommendations for China’s industrial chain upgrade in the context of dual circulations.展开更多
In this paper, the analysis of faults with different scales and orientations reveals that the distribution of fractures always develops toward a higher degree of similarity with faults, and a method for calculating th...In this paper, the analysis of faults with different scales and orientations reveals that the distribution of fractures always develops toward a higher degree of similarity with faults, and a method for calculating the multiscale areal fracture density is proposed using fault-fracture self-similarity theory. Based on the fracture parameters observed in cores and thin sections, the initial apertures of multiscale fractures are determined using the constraint method with a skewed distribution. Through calculations and statistical analyses of in situ stresses in combination with physical experiments on rocks, a numerical geomechanical model of the in situ stress field is established. The fracture opening ability under the in situ stress field is subsequently analyzed. Combining the fracture aperture data and areal fracture density at different scales, a calculation model is proposed for the prediction of multiscale and multiperiod fracture parameters, including the fracture porosity, the magnitude and direction of maximum permeability and the flow conductivity. Finally, based on the relationships among fracture aperture,density, and the relative values of fracture porosity and permeability, a fracture development pattern is determined.展开更多
Addressing the issue of the healthy and coordinated development of the population and economic factors in rural areas will not only help consolidate and expand the achievements of poverty alleviation,but will also lay...Addressing the issue of the healthy and coordinated development of the population and economic factors in rural areas will not only help consolidate and expand the achievements of poverty alleviation,but will also lay a foundation for comprehensive rural revitalization.In this paper,the spatial coupling relationship between the population and economic factors in rural areas in the QinlingDaba Mountains,China,is explored to provide a reference for rural revitalization and regional sustainable development in poverty areas.Sixty-eight county units in rural areas in the Qinling-Daba Mountains,as well as the population and economic factors in rural areas,are used to study the spatial coupling relationship between population and economy,as well as the driving mechanism,in rural areas in the Qinling-Daba Mountains from 2010 to 2020.The results show that a population contraction phenomenon occurred in the rural areas in the Qinling-Daba Mountains,and the spatial agglomeration trends of the population and economic factors were consistent.The agglomeration was mainly located in the suburban areas of the municipal area,and the agglomeration degree was significantly higher in these areas than in other areas.In terms of the spatial distribution,the economic development level of the rural areas in the northeastern part of the Qinling-Daba Mountains was generally higher than that in the central and western parts,and the unbalanced trends of the population and economic spatial differentiation in the eastern and western regions were significant.The spatial coupling relationship between the population and economy changed from coordinated development to economic advancement.This was mainly due to the mutual restriction and joint actions of the industrial structure,capital situation,natural environment,policies,and institutional regulations,among which the industrial structure and capital status had significant effects.展开更多
The development pattern, development situation, and existing problems of land exploitation in Zigui County, Three Gorges Reservoir Areas of China were presented. The sustainable development mode and its strategy in th...The development pattern, development situation, and existing problems of land exploitation in Zigui County, Three Gorges Reservoir Areas of China were presented. The sustainable development mode and its strategy in the Three Gorges Reservoir Areas was also discussed. A sustainable development framework for low mountain regions, middle mountain regions and high mountain regions was developed, and management countermeasures for structural optimization of complex ecosystems were advanced.展开更多
Accurately diagnosing and assessing complicated spatial linkages at various scales has become a crucial strategy for enhancing the efficacy of urban government policies and initiatives in the modern era.There is still...Accurately diagnosing and assessing complicated spatial linkages at various scales has become a crucial strategy for enhancing the efficacy of urban government policies and initiatives in the modern era.There is still room for improvement in identifying spatial scale disparities and coupling linkages in cities,although the standard research paradigm on urban sustainability has produced numerous positive outcomes.To advance urban sustainability research from the perspective of spatial coupling,this study used cluster and cross-tabulation analyses for considering urban sustainable development patterns from the requirements of both development scale and spatial accuracy.Subsequently,the spatial unit coupling relationship between district and street scales was explored.Our findings indicated significant scale dependence in the spatial divergence between the built environment sustainability levels of streets and the economic,social,and environmental sustainability levels of districts.The implication is that significant differences exist in the built environment levels of various sustainable development type districts.The scale effect of the spatial coupling relationship influences urban planning and the transition of sustainable development.Maintaining reasonable population density and maximizing the structure and quality of social public resources supply are priorities for streets with the highest habitat sustainability that are located in low-growth type districts.Priority should be given to population deconcentration for high habitat sustainable streets located in synergistic development type districts to increase the level of public service protection.Supporting facilities should be added to medium sustainable streets in low-growth areas to increase the mix of land use,which should encourage additional production activity concentration,thereby fostering overall economic strength.Further,increasing the accessibility of local public service facilities for low and medium sustainable streets located in ecologically biased areas should be prioritized,but a green and low-carbon orientation should be maintained during building.展开更多
"Three new developments"is the guiding ideology of Chinese-style high-quality development in the new era.Jujube(Zizyphus jujube Mill.)is a plant of Zizyphus of Rhamnaceae,which originated in China and has be..."Three new developments"is the guiding ideology of Chinese-style high-quality development in the new era.Jujube(Zizyphus jujube Mill.)is a plant of Zizyphus of Rhamnaceae,which originated in China and has been listed as one of the"five fruits"since ancient times.Xinjiang is the most important jujube producing area in China,and its yield has accounted for 50%of the national jujube yield.In the five prefectures and cities of southern Xinjiang,as well as the regimental farms of southern and eastern Xinjiang of Xinjiang Production and Construction Corps,the jujube industry is an advantageous characteristic industry in agriculture.This paper studied Xinjiang jujube industry and its agricultural intellectual property resources,analyzed six major issues to be further implemented,such as the"three new developments"thinking and the strategy of building an intellectual property power,and puts forward eight strategies such as coordinating the two markets and two resources to accelerate the construction of a new development pattern and dual circulation of jujube.展开更多
This paper examines China’s flying geese paradigm that serves as a key driver of a new pattern of the country’s economic development.Our results suggest that such a major power’s flying geese paradigm has taken sha...This paper examines China’s flying geese paradigm that serves as a key driver of a new pattern of the country’s economic development.Our results suggest that such a major power’s flying geese paradigm has taken shape in the aftermath of the global financial crisis in 2008.However,this paradigm has provincial heterogeneity in that industrial relocation varies across provinces.For instance,China’s central and western regions have shown differences while serving as destinations for labor-intensive industries and processing trade.This flying geese paradigm evolves in a slow and nonlinear manner,and may be subject to stagnation and even reversal.展开更多
On the way to the construction of new countryside, Henan province has been exploring its own new construction development pattern actively. This paper analyzes the four development patterns-Xingyang mode, Zhongmou mod...On the way to the construction of new countryside, Henan province has been exploring its own new construction development pattern actively. This paper analyzes the four development patterns-Xingyang mode, Zhongmou mode,Xinmi mode and Gongyi mode --from the perspective of ecological civilization development on the basis of sufficient data and extensive research. This also concludes their experience to realize the sustainable development of the new construction of new countryside.展开更多
Using available data and necessary estimations, this paper provides a tentative picture of the balance sheet of China＇s sovereign account between 2000 and 2010. The main findings indicate that the net worth of China...Using available data and necessary estimations, this paper provides a tentative picture of the balance sheet of China＇s sovereign account between 2000 and 2010. The main findings indicate that the net worth of China＇s sovereign assets had been positive and increasing during the period under review. This implies that the Chinese government has sufficient sovereign assets to cover its sovereign liabilities, therefore the likelihood of a sovereign debt crisis in China is extremely low in the near term. Moreover, although China＇s leverage ratio （total liabilities/GDP） is far lower compared to advanced economies, it seems higher than that of other major emerging economies such as Brazil, Russia, and India （BRIC）. In fact, the leverage ratio has been increasing rapidly over recent years and requires special attention. In particular, according to sector-specific analysis, high corporate liability ratios （percentage to GDP） constitute a major concern of China＇s national balance sheet. In 2010, this liability ratio exceeded l OO percent, which exceeds the 90 percent level observed in OECD countries. Lastly, this paper concludes that a sustainable economic growth and structural transformation of growth model are the fundamental means to taming China＇s balance sheet risks.展开更多
The overall regional development planning pattern has been considered to be a new and effective pattern as for development of provincial economy.The article analyzed the current conditions of the west of Shandong Prov...The overall regional development planning pattern has been considered to be a new and effective pattern as for development of provincial economy.The article analyzed the current conditions of the west of Shandong Province and tried to find the generation mechanisms of current non-balanced economic development of Shandong Province.And then approaches to regional development were put forward according to the theory of regional development pattern as a whole.展开更多
Foeused on the lack of proper organization for patterns in the development of pattern based software, a POMSDP model with layered tree structure for organizing patterns during the process of development was put torwar...Foeused on the lack of proper organization for patterns in the development of pattern based software, a POMSDP model with layered tree structure for organizing patterns during the process of development was put torward. The model and its interrelated eoneepts were strictly defined and introduced by applying the theory of set, symbolie logic and pattern, which ensures the correctness, maturity and expansibility of the model. The expansibility of the model was discussed mainly. The basic realization and the application in the automatic query system were presented. Based on the existing software development methods, the POMSDP model resolves the problem of chaos in the application of patterns, strengthens the controllability of the system, and facilitates the improvement, maintenance, expansion, and especially the reengineering of the software system.展开更多
基金supported by the Public Welfare Research Project for Environmental Protection (No. 201109048)the National High Technology Research and Development Program (863) of China (No. 2012AA06A302)the National Natural Science Foundation of China (No. 21077125)
文摘Considering some advantages of Rana nigromaculata as an experimental species, we propose that this species, like Xenopus laevis, could be used to assay thyroid hormone（TH） signaling disrupting actions. To validate the utilizability of R. nigromaculata, we investigated the responsiveness of R. nigromaculata to a TH receptor（TR） agonist（T3） and antagonist（amiodarone） by analyzing expression, based on characterizing TR cDNA and developmental expression patterns. With high levels of identity with the corresponding genes in X. laevis, both TRα and TRβ in R. nigromaculata exhibited roughly similar developmental expression patterns to those of X. laevis, in spite of some species-specific differences. Both TRα and TRβ expression had greater changes in the liver and intestine than in the tail and brain during metamorphosis. T3 exposure for 2 days induced more dramatic increases of TRβ expression in stage 27 than in stage34 tadpoles but not in stage 42 tadpoles, showing that the responsiveness of R. nigromaculata to TH decreased with development and disappeared at the onset of metamorphic climax.Corresponding to greater changes of TRβ expression in the liver and intestine than in the tail and brain during metamorphosis, the liver and intestine had higher responsiveness to exogenous T3 than the tail and brain. Amiodarone inhibited T3-induced TRβ expression. Our results show that R. nigromaculata can be used as a model species for assaying TH signaling disrupting actions by analyzing TRβ expression, and intestine tissues at stage 27 are ideal test materials due to high responsiveness and easy accessibility.
基金supported by the National Natural Science Foundation of China(Grants No.41931293,42271279,42293271,and 41801175).
文摘China has achieved the poverty reduction goal of the United Nations 2030 Agenda for Sustainable Development 10 years ahead of schedule,contributing significantly to global poverty reduction.Despite extended efforts in poverty elimination,there is a lack of quantitative studies categorizing and comparing poverty-elimination counties(PECs)based on their processes.This study proposes an innovative framework for analyzing PECs’development paths from the perspective of population-land-industry(PLI).We quantify the PLI matching degree of PECs in China during the critical phase of the battle against poverty through a multivariate matching model,classify PECs via K-means clustering according to the consistency in PLI matching degree evolution,and summarize the typical development patterns of PECs.Results indicate that the PLI matching degree of PECs in China increased substantially from 2015 to 2020,particularly in eastern areas,while the western region,including the Qinghai-Xizang Plateau and southwestern Xinjiang,shows untapped potential for improvement.Five types of PECs are identified,with the majority(30.1%)showing sustained moderate PLI matching and a minority(9.6%)experiencing long-term PLI mismatch.Industry is the shortfall of various PECs,and effective strategies to facilitate all types of PECs include the development of emerging businesses and the expansion of secondary and tertiary industries.Additionally,enriching rural labor force and increasing farmland use efficiency are essential for optimal PLI matching and positive interaction,ultimately ensuring poverty elimination and sustainable development.
基金Major Program of National Fund of Philosophy and Social Science of China(24&ZD148).
文摘China is one of the countries with the longest history in the world.The protection and development of historical and cultural resources is an issue worthy of attention in the fields of economic geography and urban-rural planning at the present stage.This study takes the Zhongyuan Urban Agglomeration,which is rich in historical and cultural heritage,as a specific case,analyzes the characteristics of the spatial-temporal distribution pattern of its historical and cultural resources.The results show that the distribution structure of historical and cultural element resources within the Zhongyuan Urban Agglomeration presents significant regional agglomeration and combination characteristics.In response to the analysis results,the study formulates an optimization strategy for the regional development pattern supported by the protection and development of historical and cultural resources,and initially proposes a matching spatial development pattern plan and policy recommendations for coordinated development.
基金supported by the National Science Fund for Distinguished Young Scholars(32325025)the STI2030-Major Projects(2021ZD0202500)+2 种基金the National Key Research and Development Program of China(2021YFA1101801)the National Natural Science Foundation of China(32171148,and 31770929)the Beijing Municipal Science and Technology Commission(Z181100001518001 and Z161100000216154).
文摘The oxytocin receptor(OXTR)has garnered increasing attention for its role in regulating both mature behaviors and brain development.It has been established that OXTR mediates a range of effects that are regionspecifc or period-specifc.However,the current studies of OXTR expression patterns in mice only provide limited help due to limitations in resolution.Therefore,our objective was to generate a comprehensive,high-resolution spatiotemporal expression map of Oxtr mRNA across the entire developing mouse brain.We applied RNAscope in situ hybridization to investigate the spatiotemporal expression pattern of Oxtr in the brains of male mice at six distinct postnatal developmental stages(P7,P14,P21,P28,P42,P56).We provide detailed descriptions of Oxtr expression patterns in key brain regions,including the cortex,basal forebrain,hippocampus,and amygdaloid complex,with a focus on the precise localization of Oxtr+cells and the variance of expression between diferent neurons.Furthermore,we identifed some neuronal populations with high Oxtr expression levels that have been little studied,including glutamatergic neurons in the ventral dentate gyrus,Vgat+Oxtr+cells in the basal forebrain,and GABAergic neurons in layers 4/5 of the cortex.Our study provides a novel perspective for understanding the distribution of Oxtr and encourages further investigations into its functions.
文摘The study profiles and explains the significant changes that have taken place in China's spatial development patterns since the inception of its economic reform and opening two decades ago. Principal component analysis is used to delineate spatial patterns. The analyses show that prior to the reform China's spatial development pattern was characterized by the dominance of the three municipalities and the Northeast, as well as by both the coast-interior and the north-south disparities. Northern provinces were generally more industrialized and economically powerful than the southern ones. After two decades of reform, regional development has become multi-centered with South China, the Yangtze Delta and the Beijing-Tianjin area being the three most important regions of the country. The coastal provinces as a whole rose to prominence on China's economic map while the Northeast has diminished its clout. The coast-interior gap not only remains but may have widened. The north-south disparity also still exists but there has been a role reversal with the south now in the lead position. Virtually all inland provinces now find themselves at or near the low end of the development spectrum. We argue that the major reason for the recent shifts in Chinese space economy is the spatially differentiated economic growth resulted from the reform and open door policy and from the new, uneven development strategy adopted by the Chinese government. The paper discusses four specific factors that have reshaped China's spatial development patterns.
基金sponsored by China Post-doctoral Scientific Research Foundation under the program of Research on the Effect of Trade in Services on Promoting the Position of the Yangtze Delta Region in International Division of Work(Approval No.2013M530809)key program of provincial cultural and socialsciences research of institutes of higher learning in Anhui Province Research on Developing New Advantages of Anhui's Open Economy(Approval No.SK2013ZD01)+1 种基金National Social Sciences Foundation Program Research on the Effect of Non-equity Arrangements on the Overseas Investment of Chinese Enterprises and Relevant Policies(Approval No.12BGJ039)as well as Cultural and Social Sciences Research Program of the Ministry of Education Research on the Transformation of China's ODI based on Intra-product Division of Work(Approval No.12YJC790288)
文摘Based on the latest approach for measuring technology content of import of services and with the contribution of total factor productivity(TFP) to gross industrial output as the indicator for measuring the growth pattern of China's industrial economy,this paper provides an empirical study on the effect of import technology content of trade in services on the development pattern of China's industrial economy between 2004 and2011.Result of econometric test reveals that the technology content of import of services has a significant positive effect on transforming the growth pattern of China's industrial economy.Moreover,import of new types of trade in services with high technology such as computer and information services has a much stronger positive effect compared with import of traditional trade in services with relatively low technology content such as transport.In terms of different industrial sectors,technology content of import of services has the greatest effect on transforming the development pattern of China's technologyintensive industrial sectors,followed by capital-intensive,resource-intensive and laborintensive sectors respectively.Transformation of the development pattern of China's industrial economy cannot be isolated from the system of global division of work.Against the backdrop of global service sector fragmentation,China should take the important opportunities in the development of global trade in services and give more attention to improving the quality of import of services in the interest of transforming the development pattern of its industrial economy.
基金Supported by the National Key R&D Program of China(No.2022YFC3106005)the Shandong Provincial Natural Science Foundation(No.ZR2021MD122)+1 种基金the MNR Key Laboratory of Eco-Environmental Science and Technology,China(No.MEEST-2023-04)the Shandong Provincial Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation(No.201708)。
文摘In 2022,Yellow Sea green tide caused by Ulva prolifera reached a historic minimum and the coastal areas of Shandong Peninsula were less affected.However,the largest amount of seaweed biomass has been washed ashore on Lianyungang and Rizhao coasts since 2015.We studied the development pattern of Yellow Sea green tide in 2022,and analyzed the key environmental factors on the growth and drifting,then discussed the possible reasons that resulted in the massive stranding of green tide biomass in Lianyungang and Rizhao.Results show under the combined influence of the east to southeast winds and currents with shoreward anomalies,green tide drifted to the coastal waters between Shandong and Jiangsu provinces and the distribution areas located westward compared with previous years(2008–2021).Floating U.prolifera rafts from the coastal waters of Binhai and Sheyang drifted continuously into the coastal waters of Lianyungang and Rizhao,providing important supplements for Yellow Sea green tide.Because green tide in 2022 distributed close to the coastal waters,the abundant nutrients might support their continuous high growth rate.In addition,the amount of rainfall around Shandong Peninsula from late June to early July were significantly higher than in previous years,which might promote the development of green tide to some extent.
文摘When analyzing the Chinese economy,one should not merely focus on surface phenomena,or be confined by a purely economic,partial,or static standpoint.Contrarily,we should uphold the stances and methodologies of Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era to get a clear picture of the current state,future direction,overarching strategies,and specific approaches of the Chinese economy in the context of the long-term evolution of the global economic system and China's endeavors of building a great modern socialist country.Since the launch of reform and opening up in 1978,China has effectively modernized itself through economic development.Par ticularly,in the f irst decade of the new era,China laid down rock-solid foundations and expanded vast spaces for future economic development through systematic modernization.With the advent of the post-COVID-19 era,the Chinese economy has entered a phase of great transition,and the country has set a goal of achieving high-quality development through a new development patter n in three critical decades.This will be unprecedented in China's economic history,and its significance and implications for the global economic system will also be unseen.China's strengths in terms of system,supply,demand,and talent provide important guarantees for a successful economic transition.During the transition period,China will look economic competition squarely,continuing to deepen its opening up and reform.The Chinese economy is expected to stabilize and accumulate momentum in the short term,gradually lift off in the medium term,and have a bright future in the long term.To bring that bright future into reality,China needs to strike a good balance between two“great miracles,”two“new patterns,”two“major blocs,”and two“world orders.”Further capacity building is needed to strengthen the Communist Party of China,enhance scientific and technological innovation,build China into a financial powerhouse,cultivate good relationships worldwide,and uphold national security while creating the conditions for ensuring it.
文摘Global industrial chains(GICs)have become a hallmark of the world economy underpinning the global production cycle.Since the reform and opening up was introduced in 1978,China has taken an active role in global value chains(GVCs)and become the world’s factory floor.Under the external shocks to GICs,such as US trade frictions with China and the COVID-19 pandemic,China’s traditional comparative advantages in manufacturing which include its labor force and costs are waning.This has manifested in a wave of industrial relocations from China to other countries as well as China’s weakening international competitiveness.We took stock of the concepts and journey of GVCs and elaborated the intrinsic relationship between GVCs and the new development pattern of“dual circulations”.We also analyzed the trends of GVCs,the current status and problems of China’s industrial chains,and China’s market heft,complete industrial chains and the digital economy as new strengths for industrial chain upgrade.In our conclusion,this paper put forth some policy recommendations for China’s industrial chain upgrade in the context of dual circulations.
基金supported by the Fundamental Research Funds for the Central Universities (2652017308)the National Natural Science Foundation of China (Grant Nos. 41372139 and 41072098)the National Science and Technology Major Project of China (2016ZX05046-003-001 and 2016ZX05034-004003)
文摘In this paper, the analysis of faults with different scales and orientations reveals that the distribution of fractures always develops toward a higher degree of similarity with faults, and a method for calculating the multiscale areal fracture density is proposed using fault-fracture self-similarity theory. Based on the fracture parameters observed in cores and thin sections, the initial apertures of multiscale fractures are determined using the constraint method with a skewed distribution. Through calculations and statistical analyses of in situ stresses in combination with physical experiments on rocks, a numerical geomechanical model of the in situ stress field is established. The fracture opening ability under the in situ stress field is subsequently analyzed. Combining the fracture aperture data and areal fracture density at different scales, a calculation model is proposed for the prediction of multiscale and multiperiod fracture parameters, including the fracture porosity, the magnitude and direction of maximum permeability and the flow conductivity. Finally, based on the relationships among fracture aperture,density, and the relative values of fracture porosity and permeability, a fracture development pattern is determined.
基金Under the auspices of National Natural Science Foundation of China(No.42071220,42371223)China Postdoctoral Science Foundation(No.2021M701053)Postgraduate Cultivating Innovation and Quality Improvement Action Plan of Henan University(No.SYLYC2022017)。
文摘Addressing the issue of the healthy and coordinated development of the population and economic factors in rural areas will not only help consolidate and expand the achievements of poverty alleviation,but will also lay a foundation for comprehensive rural revitalization.In this paper,the spatial coupling relationship between the population and economic factors in rural areas in the QinlingDaba Mountains,China,is explored to provide a reference for rural revitalization and regional sustainable development in poverty areas.Sixty-eight county units in rural areas in the Qinling-Daba Mountains,as well as the population and economic factors in rural areas,are used to study the spatial coupling relationship between population and economy,as well as the driving mechanism,in rural areas in the Qinling-Daba Mountains from 2010 to 2020.The results show that a population contraction phenomenon occurred in the rural areas in the Qinling-Daba Mountains,and the spatial agglomeration trends of the population and economic factors were consistent.The agglomeration was mainly located in the suburban areas of the municipal area,and the agglomeration degree was significantly higher in these areas than in other areas.In terms of the spatial distribution,the economic development level of the rural areas in the northeastern part of the Qinling-Daba Mountains was generally higher than that in the central and western parts,and the unbalanced trends of the population and economic spatial differentiation in the eastern and western regions were significant.The spatial coupling relationship between the population and economy changed from coordinated development to economic advancement.This was mainly due to the mutual restriction and joint actions of the industrial structure,capital situation,natural environment,policies,and institutional regulations,among which the industrial structure and capital status had significant effects.
文摘The development pattern, development situation, and existing problems of land exploitation in Zigui County, Three Gorges Reservoir Areas of China were presented. The sustainable development mode and its strategy in the Three Gorges Reservoir Areas was also discussed. A sustainable development framework for low mountain regions, middle mountain regions and high mountain regions was developed, and management countermeasures for structural optimization of complex ecosystems were advanced.
基金National Key R&D Program of China,No.2022YFC3800803National Natural Science Foundation of China,No.42271218。
文摘Accurately diagnosing and assessing complicated spatial linkages at various scales has become a crucial strategy for enhancing the efficacy of urban government policies and initiatives in the modern era.There is still room for improvement in identifying spatial scale disparities and coupling linkages in cities,although the standard research paradigm on urban sustainability has produced numerous positive outcomes.To advance urban sustainability research from the perspective of spatial coupling,this study used cluster and cross-tabulation analyses for considering urban sustainable development patterns from the requirements of both development scale and spatial accuracy.Subsequently,the spatial unit coupling relationship between district and street scales was explored.Our findings indicated significant scale dependence in the spatial divergence between the built environment sustainability levels of streets and the economic,social,and environmental sustainability levels of districts.The implication is that significant differences exist in the built environment levels of various sustainable development type districts.The scale effect of the spatial coupling relationship influences urban planning and the transition of sustainable development.Maintaining reasonable population density and maximizing the structure and quality of social public resources supply are priorities for streets with the highest habitat sustainability that are located in low-growth type districts.Priority should be given to population deconcentration for high habitat sustainable streets located in synergistic development type districts to increase the level of public service protection.Supporting facilities should be added to medium sustainable streets in low-growth areas to increase the mix of land use,which should encourage additional production activity concentration,thereby fostering overall economic strength.Further,increasing the accessibility of local public service facilities for low and medium sustainable streets located in ecologically biased areas should be prioritized,but a green and low-carbon orientation should be maintained during building.
基金Supported by Youth Project of National Social Science Fund of China(22CMZ015)。
文摘"Three new developments"is the guiding ideology of Chinese-style high-quality development in the new era.Jujube(Zizyphus jujube Mill.)is a plant of Zizyphus of Rhamnaceae,which originated in China and has been listed as one of the"five fruits"since ancient times.Xinjiang is the most important jujube producing area in China,and its yield has accounted for 50%of the national jujube yield.In the five prefectures and cities of southern Xinjiang,as well as the regimental farms of southern and eastern Xinjiang of Xinjiang Production and Construction Corps,the jujube industry is an advantageous characteristic industry in agriculture.This paper studied Xinjiang jujube industry and its agricultural intellectual property resources,analyzed six major issues to be further implemented,such as the"three new developments"thinking and the strategy of building an intellectual property power,and puts forward eight strategies such as coordinating the two markets and two resources to accelerate the construction of a new development pattern and dual circulation of jujube.
文摘This paper examines China’s flying geese paradigm that serves as a key driver of a new pattern of the country’s economic development.Our results suggest that such a major power’s flying geese paradigm has taken shape in the aftermath of the global financial crisis in 2008.However,this paradigm has provincial heterogeneity in that industrial relocation varies across provinces.For instance,China’s central and western regions have shown differences while serving as destinations for labor-intensive industries and processing trade.This flying geese paradigm evolves in a slow and nonlinear manner,and may be subject to stagnation and even reversal.
文摘On the way to the construction of new countryside, Henan province has been exploring its own new construction development pattern actively. This paper analyzes the four development patterns-Xingyang mode, Zhongmou mode,Xinmi mode and Gongyi mode --from the perspective of ecological civilization development on the basis of sufficient data and extensive research. This also concludes their experience to realize the sustainable development of the new construction of new countryside.
文摘Using available data and necessary estimations, this paper provides a tentative picture of the balance sheet of China＇s sovereign account between 2000 and 2010. The main findings indicate that the net worth of China＇s sovereign assets had been positive and increasing during the period under review. This implies that the Chinese government has sufficient sovereign assets to cover its sovereign liabilities, therefore the likelihood of a sovereign debt crisis in China is extremely low in the near term. Moreover, although China＇s leverage ratio （total liabilities/GDP） is far lower compared to advanced economies, it seems higher than that of other major emerging economies such as Brazil, Russia, and India （BRIC）. In fact, the leverage ratio has been increasing rapidly over recent years and requires special attention. In particular, according to sector-specific analysis, high corporate liability ratios （percentage to GDP） constitute a major concern of China＇s national balance sheet. In 2010, this liability ratio exceeded l OO percent, which exceeds the 90 percent level observed in OECD countries. Lastly, this paper concludes that a sustainable economic growth and structural transformation of growth model are the fundamental means to taming China＇s balance sheet risks.
文摘The overall regional development planning pattern has been considered to be a new and effective pattern as for development of provincial economy.The article analyzed the current conditions of the west of Shandong Province and tried to find the generation mechanisms of current non-balanced economic development of Shandong Province.And then approaches to regional development were put forward according to the theory of regional development pattern as a whole.
文摘Foeused on the lack of proper organization for patterns in the development of pattern based software, a POMSDP model with layered tree structure for organizing patterns during the process of development was put torward. The model and its interrelated eoneepts were strictly defined and introduced by applying the theory of set, symbolie logic and pattern, which ensures the correctness, maturity and expansibility of the model. The expansibility of the model was discussed mainly. The basic realization and the application in the automatic query system were presented. Based on the existing software development methods, the POMSDP model resolves the problem of chaos in the application of patterns, strengthens the controllability of the system, and facilitates the improvement, maintenance, expansion, and especially the reengineering of the software system.
