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Development of multi-functional anchorage support dynamic-static coupling performance test system and its application 被引量:4
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作者 Qi Wang Shuo Xu +4 位作者 Bei Jiang Chong Zhang Zhe Sun Jingxuan Liu Cailin Jiao 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第3期339-349,共11页
In underground engineering with complex conditions,the bolt(cable)anchorage support system is in an environment where static and dynamic stresses coexist,under the action of geological conditions such as high stresses... In underground engineering with complex conditions,the bolt(cable)anchorage support system is in an environment where static and dynamic stresses coexist,under the action of geological conditions such as high stresses and strong disturbances and construction conditions such as the application of high prestress.It is essential to study the support components performance under dynamic-static coupling conditions.Based on this,a multi-functional anchorage support dynamic-static coupling performance test system(MAC system)is developed,which can achieve 7 types of testing functions,including single component performance,anchored net performance,anchored rock performance and so on.The bolt and cable mechanical tests are conducted by MAC system under different prestress levels.The results showed that compared to the non-prestress condition,the impact resistance performance of prestressed bolts(cables)is significantly reduced.In the prestress range of 50–160 k N,the maximum reduction rate of impact energy resisted by different types of bolts is 53.9%–61.5%compared to non-prestress condition.In the prestress range of 150–300 k N,the impact energy resisted by high-strength cable is reduced by76.8%–84.6%compared to non-prestress condition.The MAC system achieves dynamic-static coupling performance test,which provide an effective means for the design of anchorage support system. 展开更多
关键词 Anchorage support system development of test system Dynamic-static coupling test Combined stress
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Development and Test of Hydrostatic Extraction Scheme in Spectral Model 被引量:4
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作者 张道民 盛华 纪立人 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 1990年第2期142-153,共12页
The introduction of 'hydrostatic extraction' scheme, or 'standard stratification approximation', into spectral model gained some advantages compared with commonly used schemes. However, computational i... The introduction of 'hydrostatic extraction' scheme, or 'standard stratification approximation', into spectral model gained some advantages compared with commonly used schemes. However, computational instability may occur for high vertical resolution versions if the stratification parameter C0 taken as a constant. In this paper, the possible cause leading to the instability is discussed and an improved scheme presented where C0 is generalized to be a function of both height and latitudes. Hence the reference atmosphere gets closer to the real atmosphere and the temperature deviation field to be expanded becomes smoother everywhere. Test by real case forecasts shows good computational stability of the new scheme and better prediction performance than-usual schemes of spectral model. 展开更多
关键词 development and test of Hydrostatic Extraction Scheme in Spectral Model
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Eye-movement Patterns of Chinese Children with Developmental Dyslexia during the Stroop Test 被引量:2
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作者 WU Yu Jia YANG Wen Han +4 位作者 WANG Qing Xiong YANG De Sheng HU Xiao Yun JING Jin LI Xiu Hong 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2018年第9期677-685,共9页
Objective To compare the eye-movement patterns of Chinese children with developmental dyslexia(DD children) with those of non-dyslexic children as they perform the Stroop Color and Word Test(SCWT), and to explore ... Objective To compare the eye-movement patterns of Chinese children with developmental dyslexia(DD children) with those of non-dyslexic children as they perform the Stroop Color and Word Test(SCWT), and to explore the relationship between their eye-movement patterns and interference effect. Methods An EyeLink II was used to record the eye-movement parameters of 32 DD children and 37 non-dyslexic children as they performed the SCWT. The independent samples t-test and repeated measures were used to analyze behavioral and eye-movement parameters. Results Compared to the control group, Chinese DD children presented lower accuracy(F = 8.488), slower response time(F = 25.306), and larger interference effect(t = 2.29); Chinese DD children also exhibited lower frequency of fixations(F = 6.069), greater numbers of saccades(F = 7.914) and fixations(F = 5.272), and shorter mean saccade distance(F = 4.03). All behavioral and eye-movement parameters differed significantly among the three tasks in the SCWT. There was significant interaction between groups and tasks in accuracy(F = 5.844), and marginally significant interaction in response time(F = 3.040). Chinese DD children tended to have lower accuracy and longer response time than the control group in the 'color-word naming' task. Conclusion Compared to non-dyslexic children, Chinese DD children are subject to a stronger interference effect. When performing the SCWT, Chinese DD children exhibit abnormal eye-movement patterns, namely shorter mean saccade distance, lower frequency of fixations, and more fixations and saccades. These abnormal eye movements may be relatively stable oculomotor patterns of DD children performing visual processing, and not influenced by impaired interference effect. 展开更多
关键词 developmental dyslexia Chinese children Eye movement Stroop Color and Word test
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Quality and Testing Standards on Rice Production in China and Development Strategies
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作者 XIE LiHong CHEN Neng DUAN BinWu 《China Standardization》 2006年第3期16-20,共5页
China is the biggest country of rice production and consumption in the world;more than 50% of the population feeds chiefly on rice. The quality of rice and its role as a staplefood carry much weight. The rice qualitie... China is the biggest country of rice production and consumption in the world;more than 50% of the population feeds chiefly on rice. The quality of rice and its role as a staplefood carry much weight. The rice qualities are those aspects concerning processing, appearance,cooking, nutrition and safety of the product. The study, formulation and implementation of standardson rice qualities and testing bear heavily on the improving of rice qualities, human health,substitution of rice varieties, promoting quality rice production and regulating rice market. 展开更多
关键词 RATE Quality and testing Standards on Rice Production in China and development Strategies
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Performance of a deep in situ pressure-preserving coring controller in a high-temperature and ultrahigh-pressure test system
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作者 Xiaojun Shi Heping Xie +4 位作者 Cong Li Jianan Li Guikang Liu Zhenxi You Mingzhong Gao 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第2期877-896,共20页
The pressure-preserving controller is the key component of deep in situ pressure-preserving coring(IPP-Coring).With increasing drilling depth,the environmental temperature and pressure increase accordingly.However,due... The pressure-preserving controller is the key component of deep in situ pressure-preserving coring(IPP-Coring).With increasing drilling depth,the environmental temperature and pressure increase accordingly.However,due to the strength and sealing problems of pressure-preserving controllers,the coring pressure is generally lower than 70 MPa.Establishing a high-temperature and ultrahigh-pressure test system is highly important for improving the strength and sealing performance of pressure-preserving controllers.This paper introduces a high-temperature and ultrahigh-pressure test system for deep IPP-Coring controller performance analysis.The device includes six parts:an auxiliary air source system,a pressurization system,a temperature control system,a hydraulic system,a data acquisition and electrical control system,and an ultrahigh-pressure vessel.The test system can reconstruct a 150℃ and 200 MPa in situ environment and simulate and test the movement state of the corer and the stability of the pressure-preserving action trigger of the pressure-preserving controller in the deep IPP-Coring process.To verify the performance of this test system,saddle-shaped pressure-preserving controllers made of four different materials were subjected to pressure tests under normal-temperature and high-temperature conditions.The results showed that the ultimate pressure-bearing capability of the pressure-preserving controller greatly varied between normal-temperature and high-temperature conditions.The pressure-preserving ability and sealing performance of the pressure-preserving controller decreased significantly at high temperature,and the pressure-preserving controller exhibited significantly different sealing failure characteristics due to material differences.This study is important for progressing the extraction and evaluation of deep reservoir resources. 展开更多
关键词 Deep mining In situ pressure-preserving coring(IPP-Coring) Deep in situ conditions test system development
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汉语发展性阅读障碍数字化诊断测验的研发与应用
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作者 王久菊 李虹 +15 位作者 张玉平 张亚静 王穗苹 赵晶晶 赵静 苏萌萌 邹丽娟 熊建萍 王吉 王少雯 梁爱民 郝文哲 马小卉 王晓怡 王玉凤 舒华 《中国心理卫生杂志》 北大核心 2026年第2期93-99,共7页
目的:研发汉语发展性阅读障碍数字化诊断测验,探索测验的信效度,计算阅读障碍的检出率,评估测验在临床上的应用价值。方法:将既往的纸质版阅读测验(汉字识别、词表朗读、快速命名、音位删除、语素产生和字形判断)转化为数字化形式,统一... 目的:研发汉语发展性阅读障碍数字化诊断测验,探索测验的信效度,计算阅读障碍的检出率,评估测验在临床上的应用价值。方法:将既往的纸质版阅读测验(汉字识别、词表朗读、快速命名、音位删除、语素产生和字形判断)转化为数字化形式,统一使用标准化录音指导语。在全国8个城市招募1800名小学1~6年级的学生进行阅读能力测评,评价测验的结构效度、效标效度和内部一致性信度,在210名儿童中检验重测信度,并计算阅读障碍的检出率。结果:因子分析发现测验的结构效度良好(χ^(2)/df=427.21,CFI=0.98,TLI=0.96,SRMR=0.03,RMSEA=0.06)。效标效度中,以教师的语文能力评价为效标,诊断测验的灵敏度为76.63%,特异度为72.81%。内部一致性效度为0.75~0.99,重测信度为0.63~0.98。阅读障碍的检出率为6.00%。结论:汉语发展性阅读障碍数字化测验的效度和信度,达到了心理测量学的要求,可用于临床实践中对阅读障碍的诊断,具有推广应用的潜力。 展开更多
关键词 阅读障碍 诊断测验 数字化 效度 信度
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儿童甲状腺激素抵抗综合征伴发育障碍2例
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作者 廖林英 李杏芳 张星星 《中国当代儿科杂志》 北大核心 2026年第1期115-119,共5页
患儿1,男,4岁,因语言发育迟缓就诊,甲状腺功能显示游离三碘甲状腺原氨酸、游离甲状腺素持续升高,促甲状腺激素正常或升高,基因检测发现THRB基因c.1373T>C(p.Val458Ala)新生杂合突变,诊断为甲状腺激素抵抗综合征(resistance to thyroi... 患儿1,男,4岁,因语言发育迟缓就诊,甲状腺功能显示游离三碘甲状腺原氨酸、游离甲状腺素持续升高,促甲状腺激素正常或升高,基因检测发现THRB基因c.1373T>C(p.Val458Ala)新生杂合突变,诊断为甲状腺激素抵抗综合征(resistance to thyroid hormone syndrome, RTH),未予特殊药物治疗,定期随访观察。患儿2,男,2岁,新生儿筛查发现促甲状腺激素升高,甲状腺功能异常持续1年10个月,伴生长迟缓及心动过速,基因检测提示THRB基因c.959G>A(p.Arg320His)新生杂合突变,诊断为垂体型RTH,予普萘洛尔控制心率。RTH临床表现异质性大,易误诊漏诊。对于不明原因甲状腺功能异常伴发育障碍的患儿,需警惕本病可能,早期THRB基因检测有助于精准诊断与治疗决策。 展开更多
关键词 甲状腺激素抵抗综合征 甲状腺激素β受体 发育障碍 基因检测 儿童
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中国香港普通话测试产品的历史演进与分层协同发展研究
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作者 朱海平 高新民 《语言战略研究》 北大核心 2026年第1期53-63,共11页
中国香港普通话测试产品30余年的发展历程,根据产品构成、供给主体、需求动因等特征可分为3个发展阶段:早期市场探索阶段(1988—1997年)、政策主导的多元发展阶段(1997—2006年)和市场主导的创新发展阶段(2006年至今)。整个发展历程呈... 中国香港普通话测试产品30余年的发展历程,根据产品构成、供给主体、需求动因等特征可分为3个发展阶段:早期市场探索阶段(1988—1997年)、政策主导的多元发展阶段(1997—2006年)和市场主导的创新发展阶段(2006年至今)。整个发展历程呈现独特的“双轨演进”特征:一方面,市场、政策、技术形成三阶段协同发展路径;另一方面,分层发展体系初步形成,构建起兼顾国家规范与本地特色的“基础层+特色层”测试产品体系。面向未来,可进一步推进分层发展,构建“基础层+特色层+国际层”的分层产品体系,通过差异化设计,动态调整市场、政策、技术三大要素在不同层级的互动关系与资源配置,使测试产品满足多元目标群体的普通话学习与认证需求,在整体上实现测试产品的基础普及性、区域适应性与国际衔接性相结合。 展开更多
关键词 中国香港 普通话测试产品 发展历程 分层协同
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Development of an ultra-high-pressure rotary combined dynamic seal and experimental study on its sealing performance in deep energy mining conditions 被引量:5
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作者 Wei Huang Gan Feng +3 位作者 Hui-Lan He Jian-Zhong Chen Jiu-Quan Wang Zhao Zhao 《Petroleum Science》 SCIE CAS CSCD 2022年第3期1305-1321,共17页
With the continuous development of deep oil and gas,minerals,geothermal resources,and other resources,there are increasingly more stringent requirements for equipment.In particular,the ultra-highpressure dynamic seals... With the continuous development of deep oil and gas,minerals,geothermal resources,and other resources,there are increasingly more stringent requirements for equipment.In particular,the ultra-highpressure dynamic seals of deep mining device need to be developed.Therefore,considering the use of dynamic seals in unique deep mining environments,an ultra-high-pressure rotating combined dynamic seal was designed and developed and its sealing performance was experimentally measured and analyzed.The results show that the experimental device can operate stably under a pressure of up to150 MPa and a rotating speed of 76 r/min,and can also operate normally under a rotating speed of up to 140 r/min and a sealing pressure of 120 MPa.During the operation of the ultra-high-pressure rotating combined dynamic seal,the sealing ring does not show obvious damage,which vouches for its sealing performance.No leakage of flow and pressure was detected in the all seal structures within the sealing pressure range of 0-150 MPa.Therefore,the dynamic sealing performance of the device is intact under ultra-high-pressure conditions and can be applied in deep mining environments at a certain depth.The research and development of this device can aid future deep energy exploration and exploitation. 展开更多
关键词 Deep energy exploitation Ultra-high-pressure Rotating combination dynamic seal development of test equipment
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Managing Health Treatment by Optimizing Complex Lab-Developed Test Configurations: A Health Informatics Perspective
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作者 Uzma Afzal Tariq Mahmood +1 位作者 Ali Mustafa Qamar Ayaz H.Khan 《Computers, Materials & Continua》 SCIE EI 2023年第6期6251-6267,共17页
A complex Laboratory Developed Test(LDT)is a clinical test developed within a single laboratory.It is typically configured from many fea-ture constraints from clinical repositories,which are part of the existing Lab-o... A complex Laboratory Developed Test(LDT)is a clinical test developed within a single laboratory.It is typically configured from many fea-ture constraints from clinical repositories,which are part of the existing Lab-oratory Information Management System(LIMS).Although these clinical repositories are automated,support for managing patient information with test results of an LDT is also integrated within the existing LIMS.Still,the support to configure LDTs design needs to be made available even in standard LIMS packages.The manual configuration of LDTs is a complex process and can generate configuration inconsistencies because many constraints between features can remain unsatisfied.It is a risky process and can lead patients to undergo unnecessary treatments.We proposed an optimized solution(opt-LDT)based on Genetic Algorithms to automate the configuration and resolve the inconsistencies in LDTs.Opt-LDT encodes LDT configuration as an optimization problem and generates a consistent configuration that satisfies the constraints of the features.We tested and validated opt-LDT for a local secondary care hospital in a real healthcare environment.Our results,averaged over ten runs,show that opt-LDT resolves 90%of inconsistencies while taking between 6 and 6.5 s for each configuration.Moreover,positive feedback based on a subjective questionnaire from clinicians regarding the performance,acceptability,and efficiency of opt-LDT motivates us to present our results for regulatory approval. 展开更多
关键词 Artificial intelligence health informatics evolutionary algorithms genetic algorithms feature selection laboratory developed test
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Research on Model Construction and Technique Support for Integrated Rehabilitation of Rock Desertification in Chaoying Small Watershed of Bijie Test Area of Guizhou Province 被引量:1
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作者 Wei Qingzhang Gao Shourong +1 位作者 Jiao Li Wu Yilan 《Meteorological and Environmental Research》 CAS 2014年第8期41-47,共7页
Selecting Chaoying small watershed with representative karst rocky desertification in the Bijie test area of Guizhou Province as an example, according to karst rocky desertiflcation degree and the existing eco-environ... Selecting Chaoying small watershed with representative karst rocky desertification in the Bijie test area of Guizhou Province as an example, according to karst rocky desertiflcation degree and the existing eco-environmental problems in the small watershed, we study developmental model and technique support system for integrated rehabilitation of rocky desertification in the small watershed, and bring forward the development model and technique integration for integrated rehabilitation of rocky desertification, which adapt to the karst areas of Bijie test area, Guizhou Province and even South China. 展开更多
关键词 Rocky desertification Integrated rehabilitation developmental model Technique integration Bijie test area China
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An Analysis of a Writing Test in a Chinese Senior High School
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作者 倪庆荣 《疯狂英语(教师版)》 2013年第2期89-95,共7页
This paper analyzes the design and implementation of a normal writing test in a senior high school. In line with theories of test evaluation, an effective writing test should try to meet the balance of the six usefuln... This paper analyzes the design and implementation of a normal writing test in a senior high school. In line with theories of test evaluation, an effective writing test should try to meet the balance of the six usefulness, which will be discussed in this paper; thereafter, pedagogical implications will be mentioned with an emphasis on how a test affects the teachers in changing their teaching approaches and motivates the learners in achieving higher goals in their writing proficiency. 展开更多
关键词 evaluation of the writing test English writing proficiency design and development of a test
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First Systematic Testing Platform for Pressurization Feed System Developed for Liquid Rocket Propellant in China
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作者 Zhang Yi Beijing Aerospace System Engineering Institute of CALT 《Aerospace China》 2011年第3期-,共1页
Beijing Aerospace System Engineering Institute of China Academy of Launch Vehicle Technology (CALT) declared recently that theinstitute has set up a laboratory whichwould operate a newly
关键词 CALT FEED First Systematic testing Platform for Pressurization Feed System Developed for Liquid Rocket Propellant in China
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Relationship between Star-Wave Test and Visual/Motor Maturity in Young Children
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作者 Shogo Komatsu 《Open Journal of Nursing》 2019年第2期173-182,共10页
The developmental maturity (M) scale using the Star-Wave Test that was independently developed by Yalon and Zion indicates poor learning abilities if the M-scale score is low, which may be caused by developmental dela... The developmental maturity (M) scale using the Star-Wave Test that was independently developed by Yalon and Zion indicates poor learning abilities if the M-scale score is low, which may be caused by developmental delays, such as intellectual disability and learning disorder or organic mental disorder. Furthermore, the distress (D) scale is thought to be influenced by mild neurological disorders, hand coordination problems, and environmental factors. In this study, we conducted a Star-Wave Test on 44 nursery school children in Japan and examined the M scale, the D scale, as well as the level of stress induced by coordination problems and the environment. The t-test was conducted on the M scale and D scale of the group without coordination problems and that with coordination problems, and we found a significant difference at 1% level. From this result, we can confirm the relationship of the M scale and the D scale with Visual and motor maturity. 展开更多
关键词 Star-Wave test Projection Drawing Method INFANCY developmentAL MATURITY SCALE DISTRESS SCALE
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儿童药物难治性癫痫的遗传学及临床特征分析 被引量:4
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作者 左然然 孙素真 《中国全科医学》 CAS 北大核心 2025年第6期756-762,共7页
背景目前儿童药物难治性癫痫(DRE)在儿童癫痫中的占比维持在30%左右,且常合并精神发育迟滞,影响患儿生活质量,因此DRE的诊疗仍然是神经病学的重大挑战。目的分析儿童DRE的遗传学特点及临床特征,为临床进行基因检测提供理论依据。方法回... 背景目前儿童药物难治性癫痫(DRE)在儿童癫痫中的占比维持在30%左右,且常合并精神发育迟滞,影响患儿生活质量,因此DRE的诊疗仍然是神经病学的重大挑战。目的分析儿童DRE的遗传学特点及临床特征,为临床进行基因检测提供理论依据。方法回顾性选取2020—2022年于河北省儿童医院住院治疗且完善基因检测的95例DRE患儿为研究对象,根据基因检测结果分为基因突变阳性组(44例)和基因突变阴性组(51例)。收集患儿的一般资料(包括性别、发病年龄、用药情况、发热惊厥史、癫痫家族史等)、临床特征(发作类型、癫痫综合征、发育情况)、辅助检查[基因检测、视频脑电图(VEEG)检查、神经影像学检查],分析DRE的遗传病因及临床特征。结果95例DRE患儿中,男55例(57.9%)、女40例(42.1%),中位发病年龄为1.00(0.50,4.00)岁,用药数量为3(2,4)种;基因突变阳性组患儿发病年龄小于基因突变阴性组(Z=-5.322,P=0.001);两组患儿性别、发热惊厥史、癫痫家族史、用药数量比较,差异均无统计学意义(P>0.05)。38例(40.0%)的患儿确诊为癫痫综合征,其中76.3%(29/38)在新生儿或婴儿期发病;基因突变阳性组患儿癫痫综合征占比高于基因突变阴性组(χ^(2)=12.065,P=0.001)。临床发作类型多样,最常见的为2种及以上发作类型,占52.6%(50/95),其次为单一局灶性发作,占33.7%(32/95);两组DRE患儿发作类型比较,差异无统计学意义(χ^(2)=2.920,P=0.404)。57例患儿完善了发育筛查,其中43例(75.4%)在发病后出现不同程度的发育迟缓,33例(76.7%)表现为全面性发育迟缓;基因突变阳性组患儿发育迟缓占比高于基因突变阴性组(χ^(2)=5.728,P=0.017)。44例患儿检出变异基因,阳性检出率为46.3%,其中以离子通道类变异为主,SCN1A为最常见的单基因突变。90例(94.7%)患儿VEEG检查异常,以局灶性癫痫放电为主;基因突变阳性组患儿高峰失律占比高于基因突变阴性组(χ^(2)=7.425,P=0.006)。25例(26.3%)患儿存在结构性病因,其中基因突变阳性组12例,基因突变阴性组13例;两组DRE患儿结构性病因比较,差异无统计学意义(χ^(2)=0.039,P=0.844)。结论遗传因素为儿童DRE的重要病因,提示发病年龄小、发育迟缓与遗传性病因有关,应积极早期完善基因检测,有助于早期诊断DRE并精准治疗。 展开更多
关键词 药物难治性癫痫 儿童 遗传学 基因检测 癫痫综合征 临床特征 全面性发育迟缓
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改良版婴幼儿孤独症筛查量表联合发育筛查量表在孤独症筛查中的应用价值
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作者 蔡一婧 王磊 《妇儿健康导刊》 2025年第5期124-127,共4页
目的 分析改良版婴幼儿孤独症筛查量表(M-CHAT)联合发育筛查量表(DST)在孤独症筛查中的应用价值。方法 选取2020年1月至2024年2月扬州市妇幼保健院收治的101例孤独症患儿为疾病组,选取同期体检的100例健康儿童设为健康组。两组均应用M-C... 目的 分析改良版婴幼儿孤独症筛查量表(M-CHAT)联合发育筛查量表(DST)在孤独症筛查中的应用价值。方法 选取2020年1月至2024年2月扬州市妇幼保健院收治的101例孤独症患儿为疾病组,选取同期体检的100例健康儿童设为健康组。两组均应用M-CHAT联合DST实施孤独症筛查,比较两组评分差异,分析M-CHAT与DST的诊断效能。结果 疾病组DST的智商、发育商评分均低于健康组(P <0.05);M-CHAT+DST联合筛查显示95例真阳性,96例真阴性;M-CHAT+DST联合筛查孤独症的灵敏度、特异度、阳性预测值、阴性预测值均高于单一量表诊断(P<0.05)。结论 儿童孤独症筛查中应用M-CHAT联合DST效能良好,可提高筛查灵敏度、特异度,能较为准确地初筛孤独症,有助于早期检出与治疗。 展开更多
关键词 孤独症筛查 改良版婴幼儿孤独症筛查量表 发育筛查量表
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陕西省6岁以下儿童智能发育情况及其影响因素分析
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作者 郑园 荚婉茹 +5 位作者 李华 程玮 王娟 张旖 朱香昱 陈艳妮 《中国优生与遗传杂志》 2025年第2期286-292,共7页
目的了解陕西省6岁以下儿童早期智能发育情况,探究其影响因素。方法通过丹佛儿童发展筛选测验分别从个人-社会、精细动作-适应性、言语和大运动4个方面评估儿童的早期智能发育水平,筛查结果分为正常组和异常组,采用自制调查问卷(该问卷... 目的了解陕西省6岁以下儿童早期智能发育情况,探究其影响因素。方法通过丹佛儿童发展筛选测验分别从个人-社会、精细动作-适应性、言语和大运动4个方面评估儿童的早期智能发育水平,筛查结果分为正常组和异常组,采用自制调查问卷(该问卷为父母报告)采集儿童的个人基本资料、生活喂养方式及家庭信息,采用Logistic回归模型分析可能影响儿童早期智能发育的因素。结果本研究共纳入1169名受试儿童,分别来自于陕西省4个县(区),其中男童623名,占53.29%,女童546名,占46.71%,丹佛儿童发展筛选测验结果异常组共50例,筛查阳性率4.28%。2组儿童在月龄(χ^(2)=11.535,P=0.008)、喂养方式(χ^(2)=13.330,P=0.001)、父亲文化程度(χ^(2)=9.685,P=0.018)和母亲文化程度(χ^(2)=9.040,P=0.025)等因素上差异有统计学意义。多因素Logistic回归分析显示,母乳喂养为儿童智能发育的保护因素(OR=3.56,P=0.002)。结论儿童早期智能发育落后,可能与非母乳喂养、农村生活以及较低的父亲或母亲文化程度有关,需引起重视。 展开更多
关键词 儿童发育 丹佛儿童发展筛选测验 保护因素 发育迟缓 横断面研究
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读心系统理论之争:双系统还是单系统?
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作者 李鸿锴 《系统科学学报》 北大核心 2025年第1期46-51,共6页
读心双系统理论的提出是为了解决读心研究中的发展谜题,该理论认为人类具备最小读心系统和完全读心系统两个独立并行的系统,二者之间没有直接的信息流通。然而,这一理论同时也面临着种种挑战,未能有效解决发展谜题。读心单系统理论认为... 读心双系统理论的提出是为了解决读心研究中的发展谜题,该理论认为人类具备最小读心系统和完全读心系统两个独立并行的系统,二者之间没有直接的信息流通。然而,这一理论同时也面临着种种挑战,未能有效解决发展谜题。读心单系统理论认为只存在一个读心系统,并借此避免了双系统理论所陷入的困境。单系统理论也可以被视为一种不同形式的双系统理论,其中系统之间是包含与被包含的关系。这导致两个读心系统理论在系统的关系上产生了争论。从心理模块性和向下模块化的角度来看,读心单系统理论要优于读心双系统理论,能对当前读心研究中的现象做出更好的解释。 展开更多
关键词 读心 错误信念测试 发展谜题 系统理论 模块
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神经发育毒性体外测试方法研究进展
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作者 雒欢 陶功华 肖萍 《中国药理学与毒理学杂志》 北大核心 2025年第8期631-638,共8页
神经发育毒性(DNT)评估是化学品安全性评价的重要环节,但传统动物实验存在周期长、成本高等局限性,开发体外测试方法可为高效筛选化学品DNT效应提供新路径。本文概述DNT体外测试组合(DNT IVB)的发展目标及测试方法,重点分析单细胞模型... 神经发育毒性(DNT)评估是化学品安全性评价的重要环节,但传统动物实验存在周期长、成本高等局限性,开发体外测试方法可为高效筛选化学品DNT效应提供新路径。本文概述DNT体外测试组合(DNT IVB)的发展目标及测试方法,重点分析单细胞模型、3D培养体系及器官芯片等技术的应用进展,并结合整合测试与评估方法,探讨DNT IVB应用前景及未来研究方向。DNT IVB结合整合测试与评估方法可显著提高化学品DNT评估效率与精准度,未来研究应聚焦开发更接近体内生理环境的类器官模型,建立科学、高效的化学品DNT评估体系,加速推动DNT IVB在全球监管层面的认可与应用,为化学品健康风险评估提供技术保障。 展开更多
关键词 神经发育毒性 神经干细胞 体外测试组合 体外测试模型 风险评估 毒性预测
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