This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although ...This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although the rural revitalization strategy has achieved significant results in improving residents’quality of life,promoting agricultural modernization,it still faces challenges such as severe loss of human resources,insufficient agricultural technological innovation,and backward infrastructure construction.In response to these challenges,this paper proposes optimization strategies from three aspects:strengthening rural education and talent team construction,promoting agricultural technology innovation and achievement transformation,and increasing investment in rural infrastructure construction.展开更多
Antarctic krill(Euphausia superba)is a keystone species in the Southern Ocean;however,seasonal variations in reproductive development for krill are complex and remains unknown.A histological investigation with observa...Antarctic krill(Euphausia superba)is a keystone species in the Southern Ocean;however,seasonal variations in reproductive development for krill are complex and remains unknown.A histological investigation with observations of external secondary sex features of krill in the south Scotia Sea region was carried out using a multi-seasonal dataset for detail reproductive descriptions for this commercially important species.The monthly development of secondary sexual characteristics,the thelycum,as well as of oocytes over a period of two years were described.It was observed that krill have diverse reproductive development characteristics within the ovary,and that this function differently between the juvenile,sub-adult,and adult stages.During the summer,adult krill ovaries are large and ripe with oocytes rich in yolk ready for release in late summer.Post spawning,the ovaries resorb,fragment,and regress throughout the autumn and winter.During reproductive diapause period,krill focus on absorbing nutrients.Un-released eggs are reabsorbed by the ovary,the permanent germinal zone is active,and early oocytes begin to develop in preparation for the egg production phase.Krill that are about to spawn have an ovary that fills the space between the digestive gland and muscle.The ovarian development of krill is divided into 10 sexual developmental stages.As a part of this study,data on the carapace thickness with similar development patterns in krill size and carapace width,was investigated for the first time to help understand krill growth and development.展开更多
With increasingly severe global climate change,a low-carbon economy has become an inevitable trend in the development of the international community.Low-carbon economy is not only related to environmental protection b...With increasingly severe global climate change,a low-carbon economy has become an inevitable trend in the development of the international community.Low-carbon economy is not only related to environmental protection but also has a profound impact on international trade.The purpose of this paper is to explore the impact of a low-carbon economy on the development of international trade and put forward corresponding strategy suggestions.By analyzing the connotation,characteristics,and mechanism of the low-carbon economy on international trade,this paper reveals the important role of the low-carbon economy in promoting the optimization of international trade structure,promoting green technology innovation,and strengthening international cooperation.At the same time,given the challenges brought by a low-carbon economy,this paper puts forward strategies such as strengthening policy guidance,promoting green technology innovation,and improving international trade rules to provide a reference for the sustainable development of international trade[1,2].展开更多
The“One Zone,Two Lands,One Park,and One Corridor”development strategy implemented in Guangxi,as a key component of China’s regional strategic deployment,provides opportunities and challenges for the development of ...The“One Zone,Two Lands,One Park,and One Corridor”development strategy implemented in Guangxi,as a key component of China’s regional strategic deployment,provides opportunities and challenges for the development of local higher education.By comparing the strategic requirements,this paper uses the SWOT analysis method to conduct an in-depth analysis of the current status of higher education in Guangxi.The analysis results show that Guangxi’s higher education has certain advantages in geographical location but lacks educational resources.At the same time,the region’s higher education faces opportunities such as policy support and local industrial transformation and upgrading,but it also faces risks such as fierce external competition,mismatches between talent supply and demand,and financial constraints.Aiming at the above problems,this paper further proposes the Opportunity Capture Strategy,Adversity Breakthrough Strategy,Advantage Defense Strategy,and Disadvantage Resolution Strategy,aiming to solve the problems faced by regional higher education in serving the transformation of local development strategies.展开更多
The emission regulations for heavy-duty diesel engines regarding nitrogen oxide(NO_(x))are becoming increasingly stringent,particularly in relation to cold start cycles.While the twostage selective catalytic reduction...The emission regulations for heavy-duty diesel engines regarding nitrogen oxide(NO_(x))are becoming increasingly stringent,particularly in relation to cold start cycles.While the twostage selective catalytic reduction(SCR)has the potential to achieve ultra-low NO_(x) emissions,several challenges remain,including the accurate prediction of ammonia(NH_(3))storage mass and the co-control of the two-stage SCR.The first step in this study involved the establishment of a rapid control prototype platform to facilitate the development and validation of a two-stage SCR control strategy.Secondly,an initial method for predicting the NH_(3) storage based on the mass conservation law was proposed,which was subsequently improved by filling and emptying experiments.The third step involved the development of a two-stage SCR co-control strategy,including obtaining the steady-state NH_(3) storage target value,dynamic correction for NH_(3) storage target value,regulation of NH_(3) storage,and control of the close-coupled SCR urea injector state.Finally,the two-stage SCR urea injection control strategy was certified under the world harmonized transient cycle(WHTC).The results demonstrate that the composite value of engine outlet NO_(x) emissions under cold and hot start WHTC cycles is 13 g/(kW·h).Meanwhile,the composite value of tailpipe NO_(x) emissions under cold and hot start WHTC cycles is 0.065 g/(kW·h),representing only 14%of the EU VI limit value of 0.46 g/(kW·h).Thus,the findings demonstrate that integrating an accurate NH_(3) storage prediction method with the two-stage SCR co-control function is crucial for heavy-duty diesel engines to achieve ultra-low NO_(x) emissions.展开更多
From the perspective of enterprise marketing strategy planning,innovative research should be conducted based on the current trends in new media.The findings should be applied to practical activities within enterprises...From the perspective of enterprise marketing strategy planning,innovative research should be conducted based on the current trends in new media.The findings should be applied to practical activities within enterprises to achieve innovation in marketing strategy decision-making in the new media environment.Enterprises should adopt advanced communication transmission technologies and big data processing capabilities to effectively leverage the hidden value and promotional planning advantages of network media platforms.This approach can enhance customer loyalty and increase demand for new products.Enterprises should integrate into the continuously evolving new media landscape,explore their potential business characteristics,and innovate promotional methods.By effectively combining product information with digital media content,companies can ultimately achieve significant increases in corporate interests.展开更多
Through conducting a SWOT analysis of the Chengdu Sports Institute Museum,and utilizing the 4M management,5W display,and 4P marketing theoretical models,this study explores effective strategies suitable for Sichuan sp...Through conducting a SWOT analysis of the Chengdu Sports Institute Museum,and utilizing the 4M management,5W display,and 4P marketing theoretical models,this study explores effective strategies suitable for Sichuan sports museums in terms of functionality,display,and marketing.展开更多
Hainan is a major tourist province.It is urgent to promote the transformation and upgrading of Hainan’s tourism industry from a traditional service industry to a modern service industry by means of informatization.Sm...Hainan is a major tourist province.It is urgent to promote the transformation and upgrading of Hainan’s tourism industry from a traditional service industry to a modern service industry by means of informatization.Smart tourism is a brand-new tourism form and operation mode of tourism transformation and upgrading.Integrating big data technology will make smart tourism more accurate in three aspects:tourism management,tourism service,and tourism marketing,and further enhance the satisfaction of the tourism experience.This paper studies the development status of smart tourism in Hainan,deeply summarizes its existing problems and causes,and puts forward the development strategy of smart tourism in Hainan to promote the healthy development of the tourism industry in Hainan.展开更多
Ferroptosis is a newly discovered form of cell death that is influenced by iron levels and is triggered by cellular metabolism and excessive lipid peroxidation.Epigenetic regulation plays a crucial role in the develop...Ferroptosis is a newly discovered form of cell death that is influenced by iron levels and is triggered by cellular metabolism and excessive lipid peroxidation.Epigenetic regulation plays a crucial role in the development and progression of diseases,making it essential to understand these mechanisms in order to identify potential targets for drug development and clinical treatment.The intersection of ferroptosis and epigenetics has opened up new avenues for research in drug development,offering innovative strategies for combating diseases.Recent studies have shown that epigenetic modifications can impact pathways related to ferroptosis,potentially leading to organ dysfunction.Despite the increasing focus on this relationship,the role of epigenetic regulation in drug development remains largely unexplored.This article explores current research on the interplay between epigenetic regulation and ferroptosis,delving into their regulatory mechanisms and discussing the effects of existing epigenetic modification regula-tors on diseases.Additionally,we highlight ongoing research on epigenetic factors involved in targeting ferroptosis in cancer,providing new insights for the development of cancer treatments.展开更多
Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy sources.This paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longe...Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy sources.This paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,respectively.MATLAB/Simulink was used for simulation test.The optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 yuan.Additionally,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations significantly.The proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.展开更多
Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-li...Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.展开更多
High-quality development requires both development-oriented and government-oriented reforms.SINCE 1978,China's policy of reform and opening-up has been pivotal in propelling the nation toward big achievements.Its ...High-quality development requires both development-oriented and government-oriented reforms.SINCE 1978,China's policy of reform and opening-up has been pivotal in propelling the nation toward big achievements.Its distinct and unique path of development has been a success due to a system and mechanisms that have been continually fine-tuned and strengthened through ongoing reforms.展开更多
China attaches great importance to food security.With the strong promotion of the government,Chinas grain output has achieved a great feat from"shortage"to"surplus in bumper years"and then to"...China attaches great importance to food security.With the strong promotion of the government,Chinas grain output has achieved a great feat from"shortage"to"surplus in bumper years"and then to"rising steadily",achieving a record"increase for the tenth consecutive year".From the current balance of food supply and demand in China,the food security situation can be guaranteed on the whole.However,if we analyze the food security in China from the perspective of agricultural sustainable development strategy,there are some difficulties,such as the reduction of cultivated land area,the decline of cultivated land quality,the fragility of agricultural ecological environment,and the transformation of residentsconsumption structure.This paper analyzes the difficulties faced by the development of food security in China under the strategy of sustainable agricultural development,and puts forward that to implement the strategy of sustainable agricultural development,it is necessary to realize the coordinated development of food security,science and technology,ecological environment,resources and society.展开更多
With the advancement and maturation of digital technology,immersive experiences,virtual interactive systems,and real physical environments are combined to create an independent“digital twin”world.In the field of int...With the advancement and maturation of digital technology,immersive experiences,virtual interactive systems,and real physical environments are combined to create an independent“digital twin”world.In the field of intelligent manufacturing,there is a growing need to explore and develop a new platform for practical teaching based on digital twins,in line with the intelligent,networked,and digital transformation of education.By analyzing the design elements of this platform,building various digital twin prototypes and environments,and developing a teaching and training platform for intelligent manufacturing based on digital twins,significant improvements can be achieved in efficiency.Therefore,this paper discusses the development of an intelligent manufacturing teaching and training platform based on digital twins,aiming to enrich both the form and content of intelligent manufacturing training.展开更多
This paper investigated and analyzed the conservation and utilization of four local livestock breeds in Binzhou City:Wadi Sheep,Bohai Black Cattle,Wudi Donkey,and Lubei White Goat.Shortcomings in the protection and ut...This paper investigated and analyzed the conservation and utilization of four local livestock breeds in Binzhou City:Wadi Sheep,Bohai Black Cattle,Wudi Donkey,and Lubei White Goat.Shortcomings in the protection and utilization of local germplasm resources were pointed out,and strategies and recommendations were proposed to promote high-quality development of livestock and poultry genetic resources in Binzhou,including building a solid germplasm foundation,standardizing production,and driving innovation.This paper provides references for the conservation,development,and utilization of local genetic resources in Binzhou City.展开更多
This paper aims to explore the development strategies for subject services in university libraries within the context of the“double first-class”initiative.By examining the relationship between“double first-class”c...This paper aims to explore the development strategies for subject services in university libraries within the context of the“double first-class”initiative.By examining the relationship between“double first-class”construction and university library subject services,the study analyzes the current state of subject services,including resource development,service models,and team building.Drawing on domestic and international case studies,the paper proposes a series of targeted and practical strategies to enhance the quality of subject services in university libraries,thereby providing robust support for the advancement of the“double first-class”initiative.展开更多
Developing deep fragmented soft coalbed methane(CBM)can significantly enhance domestic natural gas supplies,reduce reliance on imported energy,and bolster national energy security.This manuscript provides a comprehens...Developing deep fragmented soft coalbed methane(CBM)can significantly enhance domestic natural gas supplies,reduce reliance on imported energy,and bolster national energy security.This manuscript provides a comprehensive review of commonly employed coalbed methane extraction technologies.It then delves into several critical issues in the current stage of CBM exploration and development in China,including the compatibility of existing technologies with CBM reservoirs,the characteristics and occurrence states of CBM reservoirs,critical desorption pressure,and gas generation mechanisms.Our research indicates that current CBM exploration and development technologies in China have reached an internationally advanced level,yet the industry is facing unprecedented challenges.Despite progress in low-permeability,high-value coal seams,significant breakthroughs have not been achieved in exploring other types of coal seams.For different coal reservoirs,integrated extraction technologies have been developed,such as surface pre-depressurisation and segmented hydraulic fracturing of coal seam roof strata.Additionally,techniques like large-scale volume fracturing in horizontal wells have been established,significantly enhancing reservoir stimulation effects and coalbed methane recovery rates.However,all of these technologies are fundamentally based on permeation.These technologies lack direct methods aimed at enhancing the diffusion rate of CBM,thereby failing to fully reflect the unique characteristics of CBM.Current CBM exploration and development theories and technologies are not universally applicable to all coal seams.They do not adequately account for the predominantly adsorbed state of CBM,and the complex and variable gas generation mechanisms further constrain CBM development in China.Finally,continuous exploration of new deep CBM exploration technologies is necessary.Integrating more effective reservoir stimulation technologies is essential to enhance technical adaptability concerning CBM reservoir characteristics,gas occurrence states,and gas generation mechanisms,ultimately achieving efficient CBM development.We conclude that while China possesses a substantial foundation of deep fractured CBM resources,industry development is constrained and requires continuous exploration of new CBM exploration and development technologies to utilize these resources effectively.展开更多
As a representative enterprise in the retail industry,MINISO takes cost leadership and product differentiation as its core strategy to compete actively in the global market.However,multi-brand retailers continue to ap...As a representative enterprise in the retail industry,MINISO takes cost leadership and product differentiation as its core strategy to compete actively in the global market.However,multi-brand retailers continue to appear in the domestic market and the existing“dollar stores”in the foreign market already have a certain number of loyal customers.Therefore,MINISO needs to understand its principles for creating,delivering,and capturing value.By strengthening its own competitive advantages,it could achieve differentiation when confronting challenges in both domestic and international markets.Based on the analysis of MINISO’s business model canvas,this paper puts forward corresponding strategic development suggestions.展开更多
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and contin...The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.展开更多
This study examines the current state of informatization education among county high school students.While students demonstrate a strong demand for informatization education,they face significant challenges,including ...This study examines the current state of informatization education among county high school students.While students demonstrate a strong demand for informatization education,they face significant challenges,including inadequate hardware,limited access to online learning resources,and insufficient teacher proficiency in informatization education.Through a questionnaire survey,the research reveals an urgent need for expanded information technology courses and specialized training programs.In response,this paper proposes strategies such as increasing investment in IT education,optimizing teaching methodologies,and providing additional learning opportunities to enhance student engagement and comprehensively improve the quality of IT education and learning outcomes in county high schools.展开更多
文摘This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although the rural revitalization strategy has achieved significant results in improving residents’quality of life,promoting agricultural modernization,it still faces challenges such as severe loss of human resources,insufficient agricultural technological innovation,and backward infrastructure construction.In response to these challenges,this paper proposes optimization strategies from three aspects:strengthening rural education and talent team construction,promoting agricultural technology innovation and achievement transformation,and increasing investment in rural infrastructure construction.
基金Supported by the Inter-governmental Science and Technology Innovation(STI)Cooperation Special Program of the National Key Research and Development Program of China(No.2023YFE0104500)the NIWA-SHOU-Otago Joint Research Center on Antarctic Marine Science。
文摘Antarctic krill(Euphausia superba)is a keystone species in the Southern Ocean;however,seasonal variations in reproductive development for krill are complex and remains unknown.A histological investigation with observations of external secondary sex features of krill in the south Scotia Sea region was carried out using a multi-seasonal dataset for detail reproductive descriptions for this commercially important species.The monthly development of secondary sexual characteristics,the thelycum,as well as of oocytes over a period of two years were described.It was observed that krill have diverse reproductive development characteristics within the ovary,and that this function differently between the juvenile,sub-adult,and adult stages.During the summer,adult krill ovaries are large and ripe with oocytes rich in yolk ready for release in late summer.Post spawning,the ovaries resorb,fragment,and regress throughout the autumn and winter.During reproductive diapause period,krill focus on absorbing nutrients.Un-released eggs are reabsorbed by the ovary,the permanent germinal zone is active,and early oocytes begin to develop in preparation for the egg production phase.Krill that are about to spawn have an ovary that fills the space between the digestive gland and muscle.The ovarian development of krill is divided into 10 sexual developmental stages.As a part of this study,data on the carapace thickness with similar development patterns in krill size and carapace width,was investigated for the first time to help understand krill growth and development.
文摘With increasingly severe global climate change,a low-carbon economy has become an inevitable trend in the development of the international community.Low-carbon economy is not only related to environmental protection but also has a profound impact on international trade.The purpose of this paper is to explore the impact of a low-carbon economy on the development of international trade and put forward corresponding strategy suggestions.By analyzing the connotation,characteristics,and mechanism of the low-carbon economy on international trade,this paper reveals the important role of the low-carbon economy in promoting the optimization of international trade structure,promoting green technology innovation,and strengthening international cooperation.At the same time,given the challenges brought by a low-carbon economy,this paper puts forward strategies such as strengthening policy guidance,promoting green technology innovation,and improving international trade rules to provide a reference for the sustainable development of international trade[1,2].
文摘The“One Zone,Two Lands,One Park,and One Corridor”development strategy implemented in Guangxi,as a key component of China’s regional strategic deployment,provides opportunities and challenges for the development of local higher education.By comparing the strategic requirements,this paper uses the SWOT analysis method to conduct an in-depth analysis of the current status of higher education in Guangxi.The analysis results show that Guangxi’s higher education has certain advantages in geographical location but lacks educational resources.At the same time,the region’s higher education faces opportunities such as policy support and local industrial transformation and upgrading,but it also faces risks such as fierce external competition,mismatches between talent supply and demand,and financial constraints.Aiming at the above problems,this paper further proposes the Opportunity Capture Strategy,Adversity Breakthrough Strategy,Advantage Defense Strategy,and Disadvantage Resolution Strategy,aiming to solve the problems faced by regional higher education in serving the transformation of local development strategies.
基金supported by the National Natural Science Foundation of China(No.51921004).
文摘The emission regulations for heavy-duty diesel engines regarding nitrogen oxide(NO_(x))are becoming increasingly stringent,particularly in relation to cold start cycles.While the twostage selective catalytic reduction(SCR)has the potential to achieve ultra-low NO_(x) emissions,several challenges remain,including the accurate prediction of ammonia(NH_(3))storage mass and the co-control of the two-stage SCR.The first step in this study involved the establishment of a rapid control prototype platform to facilitate the development and validation of a two-stage SCR control strategy.Secondly,an initial method for predicting the NH_(3) storage based on the mass conservation law was proposed,which was subsequently improved by filling and emptying experiments.The third step involved the development of a two-stage SCR co-control strategy,including obtaining the steady-state NH_(3) storage target value,dynamic correction for NH_(3) storage target value,regulation of NH_(3) storage,and control of the close-coupled SCR urea injector state.Finally,the two-stage SCR urea injection control strategy was certified under the world harmonized transient cycle(WHTC).The results demonstrate that the composite value of engine outlet NO_(x) emissions under cold and hot start WHTC cycles is 13 g/(kW·h).Meanwhile,the composite value of tailpipe NO_(x) emissions under cold and hot start WHTC cycles is 0.065 g/(kW·h),representing only 14%of the EU VI limit value of 0.46 g/(kW·h).Thus,the findings demonstrate that integrating an accurate NH_(3) storage prediction method with the two-stage SCR co-control function is crucial for heavy-duty diesel engines to achieve ultra-low NO_(x) emissions.
文摘From the perspective of enterprise marketing strategy planning,innovative research should be conducted based on the current trends in new media.The findings should be applied to practical activities within enterprises to achieve innovation in marketing strategy decision-making in the new media environment.Enterprises should adopt advanced communication transmission technologies and big data processing capabilities to effectively leverage the hidden value and promotional planning advantages of network media platforms.This approach can enhance customer loyalty and increase demand for new products.Enterprises should integrate into the continuously evolving new media landscape,explore their potential business characteristics,and innovate promotional methods.By effectively combining product information with digital media content,companies can ultimately achieve significant increases in corporate interests.
基金Key Research Base for Humanities and Social Sciences(Sports and Social Sciences)of the Education Department of the Sichuan Federation of Social Sciences Project:“Research on Development Strategies of Sichuan Local Sports Museums under the Background of Cultural and Tourism Integration”(Project No.TY2023210)。
文摘Through conducting a SWOT analysis of the Chengdu Sports Institute Museum,and utilizing the 4M management,5W display,and 4P marketing theoretical models,this study explores effective strategies suitable for Sichuan sports museums in terms of functionality,display,and marketing.
文摘Hainan is a major tourist province.It is urgent to promote the transformation and upgrading of Hainan’s tourism industry from a traditional service industry to a modern service industry by means of informatization.Smart tourism is a brand-new tourism form and operation mode of tourism transformation and upgrading.Integrating big data technology will make smart tourism more accurate in three aspects:tourism management,tourism service,and tourism marketing,and further enhance the satisfaction of the tourism experience.This paper studies the development status of smart tourism in Hainan,deeply summarizes its existing problems and causes,and puts forward the development strategy of smart tourism in Hainan to promote the healthy development of the tourism industry in Hainan.
文摘Ferroptosis is a newly discovered form of cell death that is influenced by iron levels and is triggered by cellular metabolism and excessive lipid peroxidation.Epigenetic regulation plays a crucial role in the development and progression of diseases,making it essential to understand these mechanisms in order to identify potential targets for drug development and clinical treatment.The intersection of ferroptosis and epigenetics has opened up new avenues for research in drug development,offering innovative strategies for combating diseases.Recent studies have shown that epigenetic modifications can impact pathways related to ferroptosis,potentially leading to organ dysfunction.Despite the increasing focus on this relationship,the role of epigenetic regulation in drug development remains largely unexplored.This article explores current research on the interplay between epigenetic regulation and ferroptosis,delving into their regulatory mechanisms and discussing the effects of existing epigenetic modification regula-tors on diseases.Additionally,we highlight ongoing research on epigenetic factors involved in targeting ferroptosis in cancer,providing new insights for the development of cancer treatments.
基金supported by a Horizontal Project on the Development of a Hybrid Energy Storage Simulation Model for Wind Power Based on an RT-LAB Simulation System(PH2023000190)the Inner Mongolia Natural Science Foundation Project and the Optimization of Exergy Efficiency of a Hybrid Energy Storage System with Crossover Control for Wind Power(2023JQ04).
文摘Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy sources.This paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,respectively.MATLAB/Simulink was used for simulation test.The optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 yuan.Additionally,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations significantly.The proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.
基金supported by the National Key R&D Program of China,No.2019YFA0110300(to ZG)the National Natural Science Foundation of China,Nos.81773302(to YF),32070862(to ZG).
文摘Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.
文摘High-quality development requires both development-oriented and government-oriented reforms.SINCE 1978,China's policy of reform and opening-up has been pivotal in propelling the nation toward big achievements.Its distinct and unique path of development has been a success due to a system and mechanisms that have been continually fine-tuned and strengthened through ongoing reforms.
文摘China attaches great importance to food security.With the strong promotion of the government,Chinas grain output has achieved a great feat from"shortage"to"surplus in bumper years"and then to"rising steadily",achieving a record"increase for the tenth consecutive year".From the current balance of food supply and demand in China,the food security situation can be guaranteed on the whole.However,if we analyze the food security in China from the perspective of agricultural sustainable development strategy,there are some difficulties,such as the reduction of cultivated land area,the decline of cultivated land quality,the fragility of agricultural ecological environment,and the transformation of residentsconsumption structure.This paper analyzes the difficulties faced by the development of food security in China under the strategy of sustainable agricultural development,and puts forward that to implement the strategy of sustainable agricultural development,it is necessary to realize the coordinated development of food security,science and technology,ecological environment,resources and society.
文摘With the advancement and maturation of digital technology,immersive experiences,virtual interactive systems,and real physical environments are combined to create an independent“digital twin”world.In the field of intelligent manufacturing,there is a growing need to explore and develop a new platform for practical teaching based on digital twins,in line with the intelligent,networked,and digital transformation of education.By analyzing the design elements of this platform,building various digital twin prototypes and environments,and developing a teaching and training platform for intelligent manufacturing based on digital twins,significant improvements can be achieved in efficiency.Therefore,this paper discusses the development of an intelligent manufacturing teaching and training platform based on digital twins,aiming to enrich both the form and content of intelligent manufacturing training.
基金Supported by Binzhou Social Sciences Planning Project in 2024(24-SKGH-051)Binzhou Comprehensive Experimental Station Project of Shandong Provincial Forage Industry Technology System(SDAIT-23-10).
文摘This paper investigated and analyzed the conservation and utilization of four local livestock breeds in Binzhou City:Wadi Sheep,Bohai Black Cattle,Wudi Donkey,and Lubei White Goat.Shortcomings in the protection and utilization of local germplasm resources were pointed out,and strategies and recommendations were proposed to promote high-quality development of livestock and poultry genetic resources in Binzhou,including building a solid germplasm foundation,standardizing production,and driving innovation.This paper provides references for the conservation,development,and utilization of local genetic resources in Binzhou City.
基金Heilongjiang Provincial Library Work Committee Project“Double First-Class Construction Research on the Development Strategy of Subject Services in University Libraries”(2024-016-B)。
文摘This paper aims to explore the development strategies for subject services in university libraries within the context of the“double first-class”initiative.By examining the relationship between“double first-class”construction and university library subject services,the study analyzes the current state of subject services,including resource development,service models,and team building.Drawing on domestic and international case studies,the paper proposes a series of targeted and practical strategies to enhance the quality of subject services in university libraries,thereby providing robust support for the advancement of the“double first-class”initiative.
基金supported by the National Natural Science Foundation of China(52074045,52274074)the Science Fund for Distinguished Young Scholars of Chongqing(CSTB2022NSCQ-JQX0028).
文摘Developing deep fragmented soft coalbed methane(CBM)can significantly enhance domestic natural gas supplies,reduce reliance on imported energy,and bolster national energy security.This manuscript provides a comprehensive review of commonly employed coalbed methane extraction technologies.It then delves into several critical issues in the current stage of CBM exploration and development in China,including the compatibility of existing technologies with CBM reservoirs,the characteristics and occurrence states of CBM reservoirs,critical desorption pressure,and gas generation mechanisms.Our research indicates that current CBM exploration and development technologies in China have reached an internationally advanced level,yet the industry is facing unprecedented challenges.Despite progress in low-permeability,high-value coal seams,significant breakthroughs have not been achieved in exploring other types of coal seams.For different coal reservoirs,integrated extraction technologies have been developed,such as surface pre-depressurisation and segmented hydraulic fracturing of coal seam roof strata.Additionally,techniques like large-scale volume fracturing in horizontal wells have been established,significantly enhancing reservoir stimulation effects and coalbed methane recovery rates.However,all of these technologies are fundamentally based on permeation.These technologies lack direct methods aimed at enhancing the diffusion rate of CBM,thereby failing to fully reflect the unique characteristics of CBM.Current CBM exploration and development theories and technologies are not universally applicable to all coal seams.They do not adequately account for the predominantly adsorbed state of CBM,and the complex and variable gas generation mechanisms further constrain CBM development in China.Finally,continuous exploration of new deep CBM exploration technologies is necessary.Integrating more effective reservoir stimulation technologies is essential to enhance technical adaptability concerning CBM reservoir characteristics,gas occurrence states,and gas generation mechanisms,ultimately achieving efficient CBM development.We conclude that while China possesses a substantial foundation of deep fractured CBM resources,industry development is constrained and requires continuous exploration of new CBM exploration and development technologies to utilize these resources effectively.
文摘As a representative enterprise in the retail industry,MINISO takes cost leadership and product differentiation as its core strategy to compete actively in the global market.However,multi-brand retailers continue to appear in the domestic market and the existing“dollar stores”in the foreign market already have a certain number of loyal customers.Therefore,MINISO needs to understand its principles for creating,delivering,and capturing value.By strengthening its own competitive advantages,it could achieve differentiation when confronting challenges in both domestic and international markets.Based on the analysis of MINISO’s business model canvas,this paper puts forward corresponding strategic development suggestions.
基金supported by the National Natural Science Foundation of China,Nos.81901156(to ZZ),82271200(to ZZ),82171308(to XC)the Fundamental Research Funds for the Central Universities,No.xzy012022035(to ZZ)+1 种基金the Natural Science Foundation of Shaanxi Province,Nos.2021JM-261(to QK),2023-YBSF-303(to ZZ)Traditional Chinese Medicine Project of Shaanxi Province,No.2019-ZZ-JC047(to QK)。
文摘The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.
文摘This study examines the current state of informatization education among county high school students.While students demonstrate a strong demand for informatization education,they face significant challenges,including inadequate hardware,limited access to online learning resources,and insufficient teacher proficiency in informatization education.Through a questionnaire survey,the research reveals an urgent need for expanded information technology courses and specialized training programs.In response,this paper proposes strategies such as increasing investment in IT education,optimizing teaching methodologies,and providing additional learning opportunities to enhance student engagement and comprehensively improve the quality of IT education and learning outcomes in county high schools.
