Background:Hypertension is a significant public health concern and a leading cause of cardiovascular diseases worldwide.Urbanization has contributed to an increased prevalence of hypertension by introducing lifestyle-...Background:Hypertension is a significant public health concern and a leading cause of cardiovascular diseases worldwide.Urbanization has contributed to an increased prevalence of hypertension by introducing lifestyle-related risk factors such as physical inactivity,unhealthy dietary patterns,and stress.Region-specific tools for assessing hypertension risk factors are essential for designing effective public health interventions.Objectives:This study aimed to develop and validate a questionnaire to assess the risk factors for hypertension in the urban population of Mysuru and identify the prevalence of key modifiable and nonmodifiable risk factors.Materials and Methods:A cross-sectional study was conducted among 100 participants aged 18-60 years in urban Mysuru.A 40-item questionnaire was developed based on literature review and expert input.It included domains such as sociodemographic factors,lifestyle habits,and clinical history.Reliability was evaluated using Cronbach’s alpha,while construct validity was assessed through exploratory factor analysis.Descriptive statistics and Chi-square tests were used for data analysis.Results:The questionnaire demonstrated high internal consistency(Cronbach’s alpha>0.7)and satisfactory construct validity.Key findings included a high prevalence of low physical activity(60%),high salt intake(50%),and overweight individuals(30%).In addition,40%of participants reported a family history of hypertension,and 18%had prediabetes.These findings emphasize the role of modifiable risk factors in the rising hypertension burden in urban settings.Conclusion:The developed and validated questionnaire is a reliable and valid tool for assessing hypertension risk factors in urban populations.展开更多
Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th...Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.展开更多
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul...The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.展开更多
Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute cour...Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute course contingent upon the site of damage.The main types include amyotrophic lateral sclerosis,progressive muscular atrophy,primary lateral sclerosis,and progressive bulbar palsy,the pathological processes of which are largely identical,with the main disparity lying in the location of the lesions.Amyotrophic lateral sclerosis is the representative condition in this group of diseases,while other types are its variants.Hence,this article mainly focuses on the advancements and challenges in drug research for amyotrophic lateral sclerosis but also briefly addresses several other important degenerative motor neuron diseases.Although the precise pathogenesis remains elusive,recent advancements have shed light on various theories,including gene mutation,excitatory amino acid toxicity,autoimmunology,and neurotrophic factors.The US Food and Drug Administration has approved four drugs for use in delaying the progression of amyotrophic lateral sclerosis:riluzole,edaravone,AMX0035,and tofersen,with the latter being the most recent to receive approval.However,following several phaseⅢtrials that failed to yield favorable outcomes,AMX0035 has been voluntarily withdrawn from both the US and Canadian markets.This article presents a comprehensive summary of drug trials primarily completed between January 1,2023,and June 30,2024,based on data sourced from clinicaltrials.gov.Among these trials,five are currently in phaseⅠ,seventeen are in phaseⅡ,and eleven are undergoing phaseⅢevaluation.Notably,24 clinical trials are now investigating potential disease-modifying therapy drugs,accounting for the majority of the drugs included in this review.Some promising drugs being investigated in preclinical studies,such as ATH-1105,are included in our analysis,and another review in frontiers in gene therapy and immunotherapy has demonstrated their therapeutic potential for motor neuron diseases.This article was written to be an overview of research trends and treatment prospects related to motor neuron disease drugs,with the aim of highlighting the latest potentialities for clinical therapy.展开更多
Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a...Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.展开更多
The paper had pointed out hollow ancient town was the result of urbanization and desire; and analyzed that hollowness made ancient towns degenerate in nature, economy and social function, seriously blocking the sustai...The paper had pointed out hollow ancient town was the result of urbanization and desire; and analyzed that hollowness made ancient towns degenerate in nature, economy and social function, seriously blocking the sustainable development of economic society of ancient towns. Based on the connotation and idea of cultural reproduction, in terms of application of basic theories of cultural ecology and restoration ecology, it had established tourism development of solid ancient towns, which had been analyzed specifically from the perspectives of representation of ancient towns'scene, cultural realization and cultural promotion. By taking Zouwa Ancient Town in the west of the main urban area of Chongqing City for example, it had discussed tourism development practice of ancient towns, emphasized making Zouma scene reappear from the aspects of pattern protection, restoration and treatment of ecological environment, ancient towns' protection and cultural facilities' construction, experiencing and publicizing Zouma culture. It also highlighted taking historical and cultural heritages as the theme of tourist products, and proposed development mode of solid ancient towns, realizing reproduction of cultural heritage.展开更多
Solid oxide fuel cell(SOFC) technology and its status and problems were briefly described.Several topics for furtherresearch and development were proposed.
To study the investment activities of tourism developers in suburban tourism destinations of metropolis.421 holiday resorts around Beijing City are selected to study the evolution process of their economic types and d...To study the investment activities of tourism developers in suburban tourism destinations of metropolis.421 holiday resorts around Beijing City are selected to study the evolution process of their economic types and development modes.The results show that the development mode of holiday resorts in suburban Beijing is guided by state investment,collectively operated by rural residents,and supplemented by private or other investment types.展开更多
The moist potential vorticity (MPV) equation is derived from complete atmospheric equations including the effect of mass forcing, with which the theory of Up-sliding Slantwise Vorticity Development, (USVD) is proposed...The moist potential vorticity (MPV) equation is derived from complete atmospheric equations including the effect of mass forcing, with which the theory of Up-sliding Slantwise Vorticity Development, (USVD) is proposed based on the theory of Slantwise Vorticity Development (SVD). When an air parcel slides up along a slantwise isentropic surface, its vertical component of relative vorticity will develop, and the steeper the isentropic surface is, the more violent the development will he. From the definition of MPV and the MPV equation produced here in, a complete vorticity equation is then put forward with mass forcing, which explicitly includes the effects of both internal forcings, such as variations of stability, baroclinicity, and vertical shear of horizontal wind, arid external forcings, such as diabatic heating, friction, and mass forcing. When isentropic surfaces are flat, the complete vorticity equation matches its traditional counterpart. The physical interpretations of some of the items which are included in the complete- vorticity equation but not in the traditional one are studied with a simplified model of the Changjiang-Huaihe Meiyu front. A 60-h simulation is then performed to reproduce a torrential rain event in the Changjiang-Huaihe region and the output of the model is studied qualitatively based on the theory of USVD. The result shows that the conditions of the theory of USVD are easily satisfied immediately in front of mesoscale rainstorms in the downwind direction, that is, the theory of USVD is important to the development and movement of these kinds of systems.展开更多
Objective To develop a risk model for predicting later development of diabetic nephropathy （DN） in Chinese people with type 2 diabetes mellitus （T2DM） and evaluate its performance with independent validation. Meth...Objective To develop a risk model for predicting later development of diabetic nephropathy （DN） in Chinese people with type 2 diabetes mellitus （T2DM） and evaluate its performance with independent validation. Methods We used data collected from the project ＇Comprehensive Research on the Prevention and Control of Diabetes＇, which was a community-based study conducted by the Jiangsu Center for Disease Control and Prevention in 2013. A total of 11,771 eligible participants were included in our study. The endpoint was a clear diagnosis of DN. Data was divided into two components： a training set for model development and a test set for validation. The Cox proportional hazard regression was used for survival analysis in men and women. The model＇s performance was evaluated by discrimination and calibration. Results The incidence （cases per 10,000 person-years） of DN was 9.95 （95% CI; 8.66-11.43） in women and 11.28 （95% CI; 9.77-13.03） in men. Factors including diagnosis age, location, body mass index, high-density-lipoprotein cholesterol, creatinine, hypertension, dyslipidemia, retinopathy, diet control, and physical activity were significant in the final model. The model showed high discrimination and good calibration. Conclusion The risk model for predicting DN in people with T2DM can be used in clinical practice for improving the quality of risk management and intervention.展开更多
A new principle of geochemical conditions within a landslide slip zone is presented based on the concept of a self-sealing closed system for which newly formed pyrite should be considered as a potential indicator. Onc...A new principle of geochemical conditions within a landslide slip zone is presented based on the concept of a self-sealing closed system for which newly formed pyrite should be considered as a potential indicator. Once slip zones occur, a series of water-rock interactions may take place, particularly, a change in redox conditions simultaneously with progression of the landslide. This change induces weathering of the debris and bed rocks, and leads to accumulation of newly formed sliding mud within the slip zone. Pyrite formation along with clay mineral accumulation occurs under a weak alkaline-strong reducing environment along with landslide development. Thus, formation of neogenetic pyrite, iron speciation, and clay mineralization are all important factors for a better understanding of landslide progression.展开更多
Background:This study aimed to elucidate the molecular mechanisms of solid diet introduction initiating the cellular growth and maturation of rumen tissues and characterize the shared and unique biological processes u...Background:This study aimed to elucidate the molecular mechanisms of solid diet introduction initiating the cellular growth and maturation of rumen tissues and characterize the shared and unique biological processes upon different solid diet regimes.Methods:Twenty-four Hu lambs were randomly allocated to three groups fed following diets:goat milk powder only(M,n=8),goat milk powder+alfalfa hay(MH,n=8),and goat milk powder+concentrate starter(MC,n=8).At 42 days of age,the lambs were slaughtered.Ruminal fluid sample was collected for analysis of concentration of volatile fatty acid(VFA)and microbial crude protein(MCP).The sample of the rumen wall from the ventral sac was collected for analysis of rumen papilla morphology and transcriptomics.Results:Compared with the M group,MH and MC group had a higher concentration of VFA,MCP,rumen weight,and rumen papilla area.The transcriptomic results of rumen wall showed that there were 312 shared differentially expressed genes(DEGs)between in“MH vs.M”and“MC vs.M”,and 232 or 796 unique DEGs observed in“MH vs.M”or“MC vs.M”,respectively.The shared DEGs were most enriched in VFA absorption and metabolism,such as peroxisome proliferator-activated receptor(PPAR)signaling pathway,butanoate metabolism,and synthesis and degradation of ketone bodies.Additionally,a weighted gene co-expression network analysis identified M16(2,052 genes)and M18(579 genes)modules were positively correlated with VFA and rumen wall morphology.The M16 module was mainly related to metabolism pathway,while the M18 module was mainly associated with signaling transport.Moreover,hay specifically depressed expression of genes involved in cytokine production,immune response,and immunocyte activation,and concentrate starter mainly altered nutrient transport and metabolism,especially ion transport,amino acid,and fatty acid metabolism.Conclusions:The energy production during VFA metabolism may drive the rumen wall development directly.The hay introduction facilitated establishment of immune function,while the concentrate starter enhanced nutrient transport and metabolism,which are important biological processes required for rumen development.展开更多
The paper describes the land use situation in the project area from two aspects. Firstly, natural situation (landscape, temperature, soil hydrology, natural disasters); secondly, land use situation (land use structure...The paper describes the land use situation in the project area from two aspects. Firstly, natural situation (landscape, temperature, soil hydrology, natural disasters); secondly, land use situation (land use structure, project construction scale, land area of different vegetation classes). Through the research on the land development and consolidation of Haiba Village of Fengjie County, the project is concluded and the implementation cases of the project are reduced from the following six aspects: land leveling project, water conservancy and irrigation, farmland road engineering, project management system, project funds management and completion and delivery of construction project. Besides, the social, ecological and economic interests obtained by the projects are analyzed, so as to provide reference for promoting land development and consolidation in the future.展开更多
This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on ...This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on the basic rheological theory are presented for more applications. Further consideration of the development and application of SSM technique is also proposed.展开更多
On the basis of analysing basic features of Shiliushubao landslide, the landslide＇s deformation and development tendency are quantitatively studied by using FLA^3D program. The results accord with monitoring results....On the basis of analysing basic features of Shiliushubao landslide, the landslide＇s deformation and development tendency are quantitatively studied by using FLA^3D program. The results accord with monitoring results. The results are indicated that resevoir impounding accelerates the landslide＇s deformation, and the variation of reservoir water level is key factor of affecting the deformation; The landslide has the characters of pull-behind move ment according to the displacement of the landslide body gradually reducing from leading edge to trailing edge; Excavating and deloading slow down the landslide＇s deformation in the certain degree. On the basis, the deformation developmental tendency of Shiliushubao landslide is predicted by the established simulating model.展开更多
文摘Background:Hypertension is a significant public health concern and a leading cause of cardiovascular diseases worldwide.Urbanization has contributed to an increased prevalence of hypertension by introducing lifestyle-related risk factors such as physical inactivity,unhealthy dietary patterns,and stress.Region-specific tools for assessing hypertension risk factors are essential for designing effective public health interventions.Objectives:This study aimed to develop and validate a questionnaire to assess the risk factors for hypertension in the urban population of Mysuru and identify the prevalence of key modifiable and nonmodifiable risk factors.Materials and Methods:A cross-sectional study was conducted among 100 participants aged 18-60 years in urban Mysuru.A 40-item questionnaire was developed based on literature review and expert input.It included domains such as sociodemographic factors,lifestyle habits,and clinical history.Reliability was evaluated using Cronbach’s alpha,while construct validity was assessed through exploratory factor analysis.Descriptive statistics and Chi-square tests were used for data analysis.Results:The questionnaire demonstrated high internal consistency(Cronbach’s alpha>0.7)and satisfactory construct validity.Key findings included a high prevalence of low physical activity(60%),high salt intake(50%),and overweight individuals(30%).In addition,40%of participants reported a family history of hypertension,and 18%had prediabetes.These findings emphasize the role of modifiable risk factors in the rising hypertension burden in urban settings.Conclusion:The developed and validated questionnaire is a reliable and valid tool for assessing hypertension risk factors in urban populations.
文摘Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.
基金supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
文摘The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
基金supported by the National Key Research and Development Program of China,No.2022YFC2703101(to YC)the National Natural Science Fundation of China,No.82371422(to YC)+1 种基金the National Innovation and Entrepreneurship Training Program for College Students,No.202310611408(to XW)the 1·3·5 Project for Disciplines of Excellence Clinical Research Fund,West China Hospital,Sichuan University,No.2023HXFH032(to YC)。
文摘Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute course contingent upon the site of damage.The main types include amyotrophic lateral sclerosis,progressive muscular atrophy,primary lateral sclerosis,and progressive bulbar palsy,the pathological processes of which are largely identical,with the main disparity lying in the location of the lesions.Amyotrophic lateral sclerosis is the representative condition in this group of diseases,while other types are its variants.Hence,this article mainly focuses on the advancements and challenges in drug research for amyotrophic lateral sclerosis but also briefly addresses several other important degenerative motor neuron diseases.Although the precise pathogenesis remains elusive,recent advancements have shed light on various theories,including gene mutation,excitatory amino acid toxicity,autoimmunology,and neurotrophic factors.The US Food and Drug Administration has approved four drugs for use in delaying the progression of amyotrophic lateral sclerosis:riluzole,edaravone,AMX0035,and tofersen,with the latter being the most recent to receive approval.However,following several phaseⅢtrials that failed to yield favorable outcomes,AMX0035 has been voluntarily withdrawn from both the US and Canadian markets.This article presents a comprehensive summary of drug trials primarily completed between January 1,2023,and June 30,2024,based on data sourced from clinicaltrials.gov.Among these trials,five are currently in phaseⅠ,seventeen are in phaseⅡ,and eleven are undergoing phaseⅢevaluation.Notably,24 clinical trials are now investigating potential disease-modifying therapy drugs,accounting for the majority of the drugs included in this review.Some promising drugs being investigated in preclinical studies,such as ATH-1105,are included in our analysis,and another review in frontiers in gene therapy and immunotherapy has demonstrated their therapeutic potential for motor neuron diseases.This article was written to be an overview of research trends and treatment prospects related to motor neuron disease drugs,with the aim of highlighting the latest potentialities for clinical therapy.
基金supported by grants from the Deutsche Forschungsgemeinschaft(DFG)to MW.
文摘Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.
基金Supported by Research Project of Humanities and Social Science of Ministry of Education(No.01JD790003)~~
文摘The paper had pointed out hollow ancient town was the result of urbanization and desire; and analyzed that hollowness made ancient towns degenerate in nature, economy and social function, seriously blocking the sustainable development of economic society of ancient towns. Based on the connotation and idea of cultural reproduction, in terms of application of basic theories of cultural ecology and restoration ecology, it had established tourism development of solid ancient towns, which had been analyzed specifically from the perspectives of representation of ancient towns'scene, cultural realization and cultural promotion. By taking Zouwa Ancient Town in the west of the main urban area of Chongqing City for example, it had discussed tourism development practice of ancient towns, emphasized making Zouma scene reappear from the aspects of pattern protection, restoration and treatment of ecological environment, ancient towns' protection and cultural facilities' construction, experiencing and publicizing Zouma culture. It also highlighted taking historical and cultural heritages as the theme of tourist products, and proposed development mode of solid ancient towns, realizing reproduction of cultural heritage.
文摘Solid oxide fuel cell(SOFC) technology and its status and problems were briefly described.Several topics for furtherresearch and development were proposed.
文摘To study the investment activities of tourism developers in suburban tourism destinations of metropolis.421 holiday resorts around Beijing City are selected to study the evolution process of their economic types and development modes.The results show that the development mode of holiday resorts in suburban Beijing is guided by state investment,collectively operated by rural residents,and supplemented by private or other investment types.
基金supported by the Chinese Academy of Sciences Program of Well-Known 0verseas Chinese Scholars under Dr.Samuel Shen and the Innovation Project of the Chinese Academy of Sciences under Grant No.KZCX3-SW-213by the National Natural Science foundation of China under Grant Nos.40023001 and 40135020.
文摘The moist potential vorticity (MPV) equation is derived from complete atmospheric equations including the effect of mass forcing, with which the theory of Up-sliding Slantwise Vorticity Development, (USVD) is proposed based on the theory of Slantwise Vorticity Development (SVD). When an air parcel slides up along a slantwise isentropic surface, its vertical component of relative vorticity will develop, and the steeper the isentropic surface is, the more violent the development will he. From the definition of MPV and the MPV equation produced here in, a complete vorticity equation is then put forward with mass forcing, which explicitly includes the effects of both internal forcings, such as variations of stability, baroclinicity, and vertical shear of horizontal wind, arid external forcings, such as diabatic heating, friction, and mass forcing. When isentropic surfaces are flat, the complete vorticity equation matches its traditional counterpart. The physical interpretations of some of the items which are included in the complete- vorticity equation but not in the traditional one are studied with a simplified model of the Changjiang-Huaihe Meiyu front. A 60-h simulation is then performed to reproduce a torrential rain event in the Changjiang-Huaihe region and the output of the model is studied qualitatively based on the theory of USVD. The result shows that the conditions of the theory of USVD are easily satisfied immediately in front of mesoscale rainstorms in the downwind direction, that is, the theory of USVD is important to the development and movement of these kinds of systems.
基金supported by grants from Jiangsu Provincial Medical Innovation Team Program[grant number K201105]Jiangsu Provincial Fourth‘333 Project’[grant number BRA2013107]
文摘Objective To develop a risk model for predicting later development of diabetic nephropathy （DN） in Chinese people with type 2 diabetes mellitus （T2DM） and evaluate its performance with independent validation. Methods We used data collected from the project ＇Comprehensive Research on the Prevention and Control of Diabetes＇, which was a community-based study conducted by the Jiangsu Center for Disease Control and Prevention in 2013. A total of 11,771 eligible participants were included in our study. The endpoint was a clear diagnosis of DN. Data was divided into two components： a training set for model development and a test set for validation. The Cox proportional hazard regression was used for survival analysis in men and women. The model＇s performance was evaluated by discrimination and calibration. Results The incidence （cases per 10,000 person-years） of DN was 9.95 （95% CI; 8.66-11.43） in women and 11.28 （95% CI; 9.77-13.03） in men. Factors including diagnosis age, location, body mass index, high-density-lipoprotein cholesterol, creatinine, hypertension, dyslipidemia, retinopathy, diet control, and physical activity were significant in the final model. The model showed high discrimination and good calibration. Conclusion The risk model for predicting DN in people with T2DM can be used in clinical practice for improving the quality of risk management and intervention.
基金supported by the Three Gorges Research Center for Geo-hazard, Ministry of Education, China University of Geosciences (No. TGRC201002)Chinese Academy of Sciences as 100-Tallent Program in 2007–2011
文摘A new principle of geochemical conditions within a landslide slip zone is presented based on the concept of a self-sealing closed system for which newly formed pyrite should be considered as a potential indicator. Once slip zones occur, a series of water-rock interactions may take place, particularly, a change in redox conditions simultaneously with progression of the landslide. This change induces weathering of the debris and bed rocks, and leads to accumulation of newly formed sliding mud within the slip zone. Pyrite formation along with clay mineral accumulation occurs under a weak alkaline-strong reducing environment along with landslide development. Thus, formation of neogenetic pyrite, iron speciation, and clay mineralization are all important factors for a better understanding of landslide progression.
基金This work was supported by the Project for Top Young Talents Program of College of Animal Science and Technology of Nanjing Agricultural University(DKQB201904)National Key Research and Development Plan(2018YFD0501900)+1 种基金Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX20_0603)Science and Technology Project of Huzhou City of China(2017GY18).
文摘Background:This study aimed to elucidate the molecular mechanisms of solid diet introduction initiating the cellular growth and maturation of rumen tissues and characterize the shared and unique biological processes upon different solid diet regimes.Methods:Twenty-four Hu lambs were randomly allocated to three groups fed following diets:goat milk powder only(M,n=8),goat milk powder+alfalfa hay(MH,n=8),and goat milk powder+concentrate starter(MC,n=8).At 42 days of age,the lambs were slaughtered.Ruminal fluid sample was collected for analysis of concentration of volatile fatty acid(VFA)and microbial crude protein(MCP).The sample of the rumen wall from the ventral sac was collected for analysis of rumen papilla morphology and transcriptomics.Results:Compared with the M group,MH and MC group had a higher concentration of VFA,MCP,rumen weight,and rumen papilla area.The transcriptomic results of rumen wall showed that there were 312 shared differentially expressed genes(DEGs)between in“MH vs.M”and“MC vs.M”,and 232 or 796 unique DEGs observed in“MH vs.M”or“MC vs.M”,respectively.The shared DEGs were most enriched in VFA absorption and metabolism,such as peroxisome proliferator-activated receptor(PPAR)signaling pathway,butanoate metabolism,and synthesis and degradation of ketone bodies.Additionally,a weighted gene co-expression network analysis identified M16(2,052 genes)and M18(579 genes)modules were positively correlated with VFA and rumen wall morphology.The M16 module was mainly related to metabolism pathway,while the M18 module was mainly associated with signaling transport.Moreover,hay specifically depressed expression of genes involved in cytokine production,immune response,and immunocyte activation,and concentrate starter mainly altered nutrient transport and metabolism,especially ion transport,amino acid,and fatty acid metabolism.Conclusions:The energy production during VFA metabolism may drive the rumen wall development directly.The hay introduction facilitated establishment of immune function,while the concentrate starter enhanced nutrient transport and metabolism,which are important biological processes required for rumen development.
基金Supported by Chongqing Institute of Geology and Mineral Resources
文摘The paper describes the land use situation in the project area from two aspects. Firstly, natural situation (landscape, temperature, soil hydrology, natural disasters); secondly, land use situation (land use structure, project construction scale, land area of different vegetation classes). Through the research on the land development and consolidation of Haiba Village of Fengjie County, the project is concluded and the implementation cases of the project are reduced from the following six aspects: land leveling project, water conservancy and irrigation, farmland road engineering, project management system, project funds management and completion and delivery of construction project. Besides, the social, ecological and economic interests obtained by the projects are analyzed, so as to provide reference for promoting land development and consolidation in the future.
基金the National Natural Science foundation of China! (59995440)
文摘This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on the basic rheological theory are presented for more applications. Further consideration of the development and application of SSM technique is also proposed.
文摘On the basis of analysing basic features of Shiliushubao landslide, the landslide＇s deformation and development tendency are quantitatively studied by using FLA^3D program. The results accord with monitoring results. The results are indicated that resevoir impounding accelerates the landslide＇s deformation, and the variation of reservoir water level is key factor of affecting the deformation; The landslide has the characters of pull-behind move ment according to the displacement of the landslide body gradually reducing from leading edge to trailing edge; Excavating and deloading slow down the landslide＇s deformation in the certain degree. On the basis, the deformation developmental tendency of Shiliushubao landslide is predicted by the established simulating model.
