Conjugated microporous polymers(CMPs)are a kind of porous skeleton polymers,which are characterized by extended conjugated skeletons,large specific surface area and structure stability.In this work,a facile and versat...Conjugated microporous polymers(CMPs)are a kind of porous skeleton polymers,which are characterized by extended conjugated skeletons,large specific surface area and structure stability.In this work,a facile and versatile method was developed to fabricate flexible conjugated microporous polymer films for fast detecting the total quantity of developing agents and their oxidation products.Conjugated microporous polymer films were synthesized through in situ one-step approach by Suzuki coupling reaction.With such merits such as intense luminescence,easy synthesis and disposability,the polymer films were employed to detect developers based on fluorescence quenching in the printing wastewater.A linear response to p-benzoquinone,oxidation product of developers,was obtained in the range of 0.05-0.5 lmolL-1,with a detection limit of 0.015 lmolL-1.The strategy for in situ growth of flexible polyphenylene-conjugated microporous polymer(PP-CMP)films seems to be a very portable and general method for meeting different analytic purposes.展开更多
With the rapid advance of academic activities in the field of phar-macology,antiinflammatory and immunopharmacology has become abranch of pharmacology in our country.Under professor Zhou Jin-huang’s charge and concer...With the rapid advance of academic activities in the field of phar-macology,antiinflammatory and immunopharmacology has become abranch of pharmacology in our country.Under professor Zhou Jin-huang’s charge and concerns,the first national conference of anti-inflammatory and immunopharmacology was held at Huang Shan in1982.In following years,the frist training class for antiinflamma-tory and immunopharmacological studies was conducted in Hefei.展开更多
This review starts with a brief history of drug discovery & development, and the place of Asia in this worldwide effort discussed. The conditions and constraints of a successful translational R&D involving aca...This review starts with a brief history of drug discovery & development, and the place of Asia in this worldwide effort discussed. The conditions and constraints of a successful translational R&D involving academic basic research and clinical research are discussed and the Singapore model for pursuit of open R&D described. The importance of well-characterized, validated drug targets for the search for novel targeted anti-cancer agents is emphasized, as well as a structured, high quality translational R&D. Furthermore, the characteristics of an attractive preclinical development drug candidate are discussed laying the foundation of a successful preclinical development. The most frequent sources of failures are described and risk management at every stage is highly recommended. Organizational factors are also considered to play an important role. The factors to consider before starting a new drug discovery & development project are described, and an example is given of a successful clinical project that has had its roots in local universities and was carried through preclinical development into phase I clinical trials.展开更多
[Objectives]The paper was to establish a TLC identification method for Ensete wilsonii.[Methods]Usingβ-sitosterol as the reference,the effects of preparation methods of test solutions,developing solvents,developing d...[Objectives]The paper was to establish a TLC identification method for Ensete wilsonii.[Methods]Usingβ-sitosterol as the reference,the effects of preparation methods of test solutions,developing solvents,developing distances and color developing agents on TLC analysis were investigated,and the best TLC conditions for E.wilsonii were determined.[Results]The test solution prepared with 90%methanol solvent was dotted on TLC silica gel G plate,and developed with dichloromethane-toluene-methanol=10:5:1.5 as the developing solvent.Then the plate was sprayed with 10%sulfuric acid ethanol solution,and dried with hot blast for color development.Finally,the plate was examined under an ultraviolet lamp at 365 nm.The TLC results of E.wilsonii obtained showed good separation and color development effect,and the spots were clear and characteristic.[Conclusions]This method is safe,specific,and easy to operate,and can be used as a TLC identification method for E.wilsonii.展开更多
Background:Invaluable forensic evidence can be found in latent fingerprints,which are invisible to the naked eye.The integrity of the evidence may be compromised by conventional fingerprint production techniques that ...Background:Invaluable forensic evidence can be found in latent fingerprints,which are invisible to the naked eye.The integrity of the evidence may be compromised by conventional fingerprint production techniques that use chemicals,powders,and lasers and pose environmental dangers.Pomegranate peel powder,made from the rind of the fruit that is native to the Middle East and SouthAsia,offers a natural alternative.Aims and Objectives:The usefulness of pomegranate peel powder as a non-damaging agent for latent fingerprint development on a variety of non-porous surfaces is investigated in this study.Materials and Methods:The powder is used to develop all three types of fingerprints i.e.sebaceous,eccrine and natural on various non-porous surfaces(steel,glass slide,iron and granite).Results:According to our study,pomegranate peel powder produces remarkable outcomes and highlights its non-toxic properties and ability to preserve the evidence.Conclusion:Pomegranate peel powder can be an effective and environmentally friendly alternative to traditional techniques for fingerprinting in forensic science.展开更多
The aerial oxidation kinetics of hydroquinone in a freshly prepared developer solution at different temperatures and pHs has been studied. The activation parameters, Ea, ΔG#, ΔS#, ΔH# and enthalpy of formation of a...The aerial oxidation kinetics of hydroquinone in a freshly prepared developer solution at different temperatures and pHs has been studied. The activation parameters, Ea, ΔG#, ΔS#, ΔH# and enthalpy of formation of activated complex, ΔH0f(X# ), are determined. The large negative value of free energy of activation ΔG# proves that hydroquinone extremely tends to be oxidized by air at optimum temperature (20°C and optimum pH (10.5) and converts to the activated complex semiquinone. It was also found that if the pH of the developer solution is increased from 9.3 to 10.5 the reaction rate will increase by a factor of 2.展开更多
基金The work were supported by the National Natural Science Foundation of China(Nos.21575168,21277176,21475153 and 21675178)the Guangdong Provincial Natural Science Foundation of China(No.2015A030311020)+1 种基金the Special Funds for Public Welfare Research and Capacity Building in Guangdong Province of China(No.2015A030401036)the Guangzhou Science and Technology Program of China(No.201604020165),respectively。
文摘Conjugated microporous polymers(CMPs)are a kind of porous skeleton polymers,which are characterized by extended conjugated skeletons,large specific surface area and structure stability.In this work,a facile and versatile method was developed to fabricate flexible conjugated microporous polymer films for fast detecting the total quantity of developing agents and their oxidation products.Conjugated microporous polymer films were synthesized through in situ one-step approach by Suzuki coupling reaction.With such merits such as intense luminescence,easy synthesis and disposability,the polymer films were employed to detect developers based on fluorescence quenching in the printing wastewater.A linear response to p-benzoquinone,oxidation product of developers,was obtained in the range of 0.05-0.5 lmolL-1,with a detection limit of 0.015 lmolL-1.The strategy for in situ growth of flexible polyphenylene-conjugated microporous polymer(PP-CMP)films seems to be a very portable and general method for meeting different analytic purposes.
文摘With the rapid advance of academic activities in the field of phar-macology,antiinflammatory and immunopharmacology has become abranch of pharmacology in our country.Under professor Zhou Jin-huang’s charge and concerns,the first national conference of anti-inflammatory and immunopharmacology was held at Huang Shan in1982.In following years,the frist training class for antiinflamma-tory and immunopharmacological studies was conducted in Hefei.
文摘This review starts with a brief history of drug discovery & development, and the place of Asia in this worldwide effort discussed. The conditions and constraints of a successful translational R&D involving academic basic research and clinical research are discussed and the Singapore model for pursuit of open R&D described. The importance of well-characterized, validated drug targets for the search for novel targeted anti-cancer agents is emphasized, as well as a structured, high quality translational R&D. Furthermore, the characteristics of an attractive preclinical development drug candidate are discussed laying the foundation of a successful preclinical development. The most frequent sources of failures are described and risk management at every stage is highly recommended. Organizational factors are also considered to play an important role. The factors to consider before starting a new drug discovery & development project are described, and an example is given of a successful clinical project that has had its roots in local universities and was carried through preclinical development into phase I clinical trials.
基金Supported by Innovation Project of Guangxi Graduate Education of GXUCM(YCSY2022012)High-level Innovation Team and Outstanding Scholars Program of Universities and Colleges in Guangxi(GJR[2014]07)Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica(20-065-38).
文摘[Objectives]The paper was to establish a TLC identification method for Ensete wilsonii.[Methods]Usingβ-sitosterol as the reference,the effects of preparation methods of test solutions,developing solvents,developing distances and color developing agents on TLC analysis were investigated,and the best TLC conditions for E.wilsonii were determined.[Results]The test solution prepared with 90%methanol solvent was dotted on TLC silica gel G plate,and developed with dichloromethane-toluene-methanol=10:5:1.5 as the developing solvent.Then the plate was sprayed with 10%sulfuric acid ethanol solution,and dried with hot blast for color development.Finally,the plate was examined under an ultraviolet lamp at 365 nm.The TLC results of E.wilsonii obtained showed good separation and color development effect,and the spots were clear and characteristic.[Conclusions]This method is safe,specific,and easy to operate,and can be used as a TLC identification method for E.wilsonii.
文摘Background:Invaluable forensic evidence can be found in latent fingerprints,which are invisible to the naked eye.The integrity of the evidence may be compromised by conventional fingerprint production techniques that use chemicals,powders,and lasers and pose environmental dangers.Pomegranate peel powder,made from the rind of the fruit that is native to the Middle East and SouthAsia,offers a natural alternative.Aims and Objectives:The usefulness of pomegranate peel powder as a non-damaging agent for latent fingerprint development on a variety of non-porous surfaces is investigated in this study.Materials and Methods:The powder is used to develop all three types of fingerprints i.e.sebaceous,eccrine and natural on various non-porous surfaces(steel,glass slide,iron and granite).Results:According to our study,pomegranate peel powder produces remarkable outcomes and highlights its non-toxic properties and ability to preserve the evidence.Conclusion:Pomegranate peel powder can be an effective and environmentally friendly alternative to traditional techniques for fingerprinting in forensic science.
文摘The aerial oxidation kinetics of hydroquinone in a freshly prepared developer solution at different temperatures and pHs has been studied. The activation parameters, Ea, ΔG#, ΔS#, ΔH# and enthalpy of formation of activated complex, ΔH0f(X# ), are determined. The large negative value of free energy of activation ΔG# proves that hydroquinone extremely tends to be oxidized by air at optimum temperature (20°C and optimum pH (10.5) and converts to the activated complex semiquinone. It was also found that if the pH of the developer solution is increased from 9.3 to 10.5 the reaction rate will increase by a factor of 2.
