Advanced sensing devices based on metasurfaces have emerged as a revolutionary platform for innovative label-free biosensors,holding promise for early diagnostics and the detection of low-concentration analytes.Here,w...Advanced sensing devices based on metasurfaces have emerged as a revolutionary platform for innovative label-free biosensors,holding promise for early diagnostics and the detection of low-concentration analytes.Here,we developed a chip-based ultrasensitive terahertz(THz)metasensor,leveraging a quasi-bound state in the continuum(q-BIC)to address the challenges associated with intricate operations in trace biochemical detection.The metasensor design features an open-ring resonator metasurface,which supports magnetic dipole q-BIC combining functionalized gold nanoparticles(AuNPs)bound with a specific antibody.The substantial enhancement in THz–analyte interactions,facilitated by the potent near-field enhancement enabled by the q-BICs,results in a substantial boost in biosensor sensitivity by up to 560 GHz/refractive index units.This methodology allows for the detection of conjugated antibody–AuNPs for cardiac troponin I at concentrations as low as 0.5 pg/ml.These discoveries deliver valuable insight for AuNP-based trace biomolecule sensing and pave the path for the development of chip-scale biosensors with profound light–matter interactions.展开更多
基金supported by the Young Scientists Fund of the National Natural Science Foundation of China(grant nos.62305394 and 62205380)the National Science Fund for Distinguished Young Scholar(grant no.12225511)the National Science Fund of China Major Project(grant no.T2241002).
文摘Advanced sensing devices based on metasurfaces have emerged as a revolutionary platform for innovative label-free biosensors,holding promise for early diagnostics and the detection of low-concentration analytes.Here,we developed a chip-based ultrasensitive terahertz(THz)metasensor,leveraging a quasi-bound state in the continuum(q-BIC)to address the challenges associated with intricate operations in trace biochemical detection.The metasensor design features an open-ring resonator metasurface,which supports magnetic dipole q-BIC combining functionalized gold nanoparticles(AuNPs)bound with a specific antibody.The substantial enhancement in THz–analyte interactions,facilitated by the potent near-field enhancement enabled by the q-BICs,results in a substantial boost in biosensor sensitivity by up to 560 GHz/refractive index units.This methodology allows for the detection of conjugated antibody–AuNPs for cardiac troponin I at concentrations as low as 0.5 pg/ml.These discoveries deliver valuable insight for AuNP-based trace biomolecule sensing and pave the path for the development of chip-scale biosensors with profound light–matter interactions.
