To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concret...To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete beams.Based on the measurement and ana-lysis of beam deflection,strain,and crack development under various loading levels during the research tests,combined with the verification coefficient indicators specified in the codes,the verification coefficients of bridges at different stages of damage can be examined.The results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test process.In the complete linear elastic stage,both the deflection and bottom strain verification coefficients comply with the specifications,indicating a good structural load-bearing capacity no longer adheres to the code’s requirements.In the non-linear stage,both coefficients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing capacity.According to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s specified range.The strain verification coefficient sourced from the compression zone at the bottom of theflange is not recommended for assessing the bridge’s load-bearing capacity.展开更多
Air blasts induced by rock-ice avalanches are common natural phenomena known for their far-field destructive impact.In this study,remote sensing images,eyewitness videos and numerical modelling were comprehensively ap...Air blasts induced by rock-ice avalanches are common natural phenomena known for their far-field destructive impact.In this study,remote sensing images,eyewitness videos and numerical modelling were comprehensively applied to analyze the initiation and propagation of the 2021 Chamoli avalancheinduced air blast.Our findings indicate that air blasts are observed from the avalanche source area to the Rishiganga valley,but nearly disappear in the Dhauliganga valley.The most intense air blast is concentrated on the left side of Ronti Gad valley,with maximum velocity and pressure estimated at over 70 m/s and 20 kPa,respectively.Such high pressure results in widespread tree breakage in the area.Based on the analysis of the Chamoli event,we further discussed the potential contribution of the avalanche flow regime,avalanche dynamics and geomorphology to the destructive potential of air blasts.Rapidly moved sliding mass can impart the air blast a high initial momentum,and this process will be exaggerated when the avalanche impacts valley walls at bends.However,when the rock-ice avalanche transforms into a debris-enriched flash flood,free water within the flowing mass can displace air,inhibiting the generation of air blasts.Our work offers new insights into the generation and propagation of rock-ice avalanche-induced air blasts,underscoring the importance of including this type of hazard during avalanche risk assessment in high-altitude glacial regions.展开更多
Airblasts,as one common phenomenon accompanied by rapid movements of landslides or rock/snow avalanches,commonly result in catastrophic damages and are attracting more and more scientific attention.To quantitatively a...Airblasts,as one common phenomenon accompanied by rapid movements of landslides or rock/snow avalanches,commonly result in catastrophic damages and are attracting more and more scientific attention.To quantitatively analyze the intensity of airblast initiated by landslides,the Wangjiayan landslide,occurred in the Wenchuan earthquake,is selected here with the landslide propagation and airblast evolution being studied using FLUENT by introducing the Voellmy rheological law.The results reveal that:(1)For the Wangjiayan landslide,its whole travelling duration is only 12 s with its maximum velocity reaching 36 m/s at t=10 s;(2)corresponding to the landslide propagation,the maximum velocity,28 m/s,of the airblast initiated by the landslide also appears at t=10 s with its maximum pressure reaching594.8 Pa,which is equivalent to violent storm;(3)under the attack of airblast,the load suffered by buildings in the airblast zone increases to 1300 Pa at t=9.4 s and sharply decreased to-7000 Pa as the rapid decrease of the velocity of the sliding mass at t=10 s,which is seriously unfavorable for buildings and might be the key reason for the destructive collapse of buildings in the airblast zone of the Wangjiayan landslide.展开更多
NF_(3)is commonly used as an etching and cleaning gas in semiconductor industry,however it is a strongly greenhouse gas.Therefore,the destruction of disposal NF_(3)is an urgent task to migrate the greenhouse effect.Am...NF_(3)is commonly used as an etching and cleaning gas in semiconductor industry,however it is a strongly greenhouse gas.Therefore,the destruction of disposal NF_(3)is an urgent task to migrate the greenhouse effect.Among the technologies for NF_(3)abatement,the destructive sorption of NF_(3)over metal oxides sorbents is an effective way.Thus,the search for a highly reactive and utilized sorbent for NF_(3)destruction is in great demand.In this work,AlOOH supported on carbon-sphere(AlOOH/CS)as precursors were synthesized hydrothermally and heat-treated to prepare the Al_(2)O_(3)sorbents.The influence of AlOOH/CS hydrothermal temperatures on the reactivity of derived Al_(2)O_(3)sorbents for NF_(3)destruction was investigated,and it is shown that the Al2O3 from AlOOH/CS hydro-thermalized at 120℃is superior to others.Subsequently,the optimized Al_(2)O_(3)was covered by Mn(OH)x to prepare Mn/Al_(2)O_(3)sorbents via changing hydrothermal temperatures and Mn loadings.The results show that the Mn/Al_(2)O_(3)sorbents are more utilized than bare Al_(2)O_(3)in NF_(3)destructive sorption due to the promotional effect of Mn_(2)O_(3)as surface layer on the fluorination of Al_(2)O_(3)as substrate,especially the optimal 5%Mn/Al2O3(160℃)exhibits a utilization percentage as high as 90.4%,and remarkably exceeds all the sorbents reported so far.These findings are beneficial to develop more efficient sorbents for the destruction of NF_(3).展开更多
Catalytic destruction is an ascendant technology for the abatement of volatile organic compounds(VOCs)originating fromsolvent-based industrial processes.The varied composition tends to influence each VOC’s catalytic ...Catalytic destruction is an ascendant technology for the abatement of volatile organic compounds(VOCs)originating fromsolvent-based industrial processes.The varied composition tends to influence each VOC’s catalytic behavior in the reaction mixture.We investigated the catalytic destruction of multi-component VOCs including dichloromethane(DCM)and ethyl acetate(EA),as representatives from pharmaceutical waste gases,over co-supported HxPO_(4)-RuOx/CeO_(2) catalyst.A mutual inhibitory effect relating to concentrations because of competitive adsorption was verified in the binary VOCs oxidation and EA posed a more negative effect on DCM oxidation owing to EA’s superior adsorption capacity.Preferential adsorption of EA on acidic sites(HxPO_(4)/CeO_(2))promoted DCM activation on basic sites(O^(2−))and the dominating EA oxidation blocked DCM’s access to oxidation centers(RuOx/CeO_(2)),resulting in boosted monochloromethane yield and increased chlorine deposition for DCM oxidation.The impaired redox ability of Ru species owing to chlorine deposition in turn jeopardized deep oxidation of EA and its by-products,leading to increased gaseous by-products such as acetic acid originating fromEA pyrolysis.Notably,DCM at low concentration slightly promoted EA conversion at low temperatures with or without water,consistent with the enhanced EA adsorption in co-adsorption analyses.This was mainly due to that DCM impeded the shielding effect of hydrolysate deposition from rapid EA hydrolysis depending on the decreased acidity.Moreover,water benefited EA hydrolysis but decreased CO_(2) selectivity while the generated water derived from EA was likely to affect DCM transformation.This work may provide theoretical guidance for the promotion of applied catalysts toward industrial applications.展开更多
Temporomandibular joint(TMJ)disc displacement is one of the most significant subtypes of temporomandibular joint disorders,but its etiology and mechanism are poorly understood.In this study,we elucidated the mechanism...Temporomandibular joint(TMJ)disc displacement is one of the most significant subtypes of temporomandibular joint disorders,but its etiology and mechanism are poorly understood.In this study,we elucidated the mechanisms by which destruction of inflamed collagen fibrils induces alterations in the mechanical properties and positioning of the TMJ disc.By constructing a rat model of TMJ arthritis,we observed anteriorly dislocated TMJ discs with aggravated deformity in vivo from five weeks to six months after a local injection of Freund’s complete adjuvant.By mimicking inflammatory conditions with interleukin-1 beta in vitro,we observed enhanced expression of collagen-synthesis markers in primary TMJ disc cells cultured in a conventional two-dimensional environment.In contrast,three-dimensional(3D)-cultivated disc cell sheets demonstrated the disordered assembly of inflamed collagen fibrils,inappropriate arrangement,and decreased Young’s modulus.Mechanistically,inflammation-related activation of the nuclear factor kappa-B(NF-κB)pathway occurs during the progression of TMJ arthritis.NF-κB inhibition reduced the collagen fibril destruction in the inflamed disc cell sheets in vitro,and early NF-κB blockade alleviated collagen degeneration and dislocation of the TMJ discs in vivo.Therefore,the NF-κB pathway participates in the collagen remodeling in inflamed TMJ discs,offering a potential therapeutic target for disc displacement.展开更多
With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.Howev...With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.However,battlefield uncertainties,such as equipment failures and enemy attacks,can impact these collaborative operations'stability and communication efficiency.To this end,we design a highly destruction-resistant air-ground cooperative resilient networking platform that aims to enhance the robustness of network communications by integrating ground vehicle information for UAV network deployment.It then incorporates the concept of virtual guiding force,enabling the UAV swarm to adaptively configure its network layout based on ground vehicle information,thereby improving network destruction resistance.Simulation results demonstrate that the UAV swarm involved in the proposed platform exhibits balanced flight energy consumption and excellent performance in network destruction resistance.展开更多
Photocatalytic disinfection is an eco-friendly strategy for countering bacterial pollution in aquatic environments.Numerous strategies have been devised to facilitate the generation of reactive oxygen species(ROS)with...Photocatalytic disinfection is an eco-friendly strategy for countering bacterial pollution in aquatic environments.Numerous strategies have been devised to facilitate the generation of reactive oxygen species(ROS)within photocatalysts,ultimately leading to the eradication of bacteria.However,the significance of the physical morphology of photocatalysts in the context of sterilization is frequently obscured,and the progress in the development of physical-chemical synergistic sterilization photocatalysts has been relatively limited.Herein,graphitic carbon nitride(g-C_(3)N_(4))is chemically protonated to expose more sharp edges.PL fluorescence and EIS results indicate that the protonation can accelerate photogenerated carrier separation and enhance ROS production.Meanwhile,the sharp edges on the protonated g-C_(3)N_(4)facilitate the physical disruption of cell walls for further promoting oxidative damage.Protonated C_(3)N_(4)demonstrated superior bactericidal performance than that of pristine g-C_(3)N_(4),effectively eliminating Escherichia coli within 40 minutes under irradiation.This work highlights the significance of incorporating physical and chemical synergies in photocatalyst design to enhance the disinfection efficiency of photocatalysis.展开更多
BACKGROUND Although laparoscopic gastrolithotomy had been widely used in clinical practice,uncommon postoperative complications still require vigilance by medical staff.CASE SUMMARY Here we report a 67-year-old man wh...BACKGROUND Although laparoscopic gastrolithotomy had been widely used in clinical practice,uncommon postoperative complications still require vigilance by medical staff.CASE SUMMARY Here we report a 67-year-old man who suffered for 18 months and underwent surgery several times due to a rare and undetected complication of laparoscopic gastricolithotomy.He presented to multiple hospitals because of sustained left upper quadrant abdominal pain one month after laparoscopic gastricolithotomy due to a large gastric bezoar caused by unrestrained eating of black dates and was diagnosed with possible intercostal neuritis.Many painkillers were used to relieve his symptoms but the condition progressed.Seven months after surgery,he was hospitalized as skin ulceration occurred in the left upper abdominal wall and was subsequently diagnosed with a massive thoracoabdominal wall abscess.One year after surgery,irreversible costal destruction was demonstrated.Both lesions were finally proved to be secondary damage due to a rare chronic gastro-abdominal wall fistula related to laparoscopic gastricolithotomy and the diameter of the gastric fistula reached 2 centimeters(cm).The patient was ultimately cured but underwent multi-regional incisions and drainage of the abscess,drainage of the gastric fistula,partial gastrectomy and removal of damaged ribs,and was followed-up for more than 4 years without recurrence.It is well-known that gastric fistula usually has an acute onset and occurs early after surgery,while chronic gastro-abdominal wall fistula especially with secondary massive thoracoabdominal wall abscess and costal destruction has rarely been reported.CONCLUSION This may be the first reported case of a chronic thoracoabdominal abscess and costal destruction caused by an undetected chronic gastro-abdominal wall fistula.We believe that this is a novel type of gastric fistula and the diagnosis and treatment were challenging.展开更多
Dear Editor,I am Yuki Tanaka from Hakodate Central General Hospital,Japan.Mikulicz’s disease is characterized by symmetrical swelling of lacrimal and salivary glands.In 2012,a Japanese study group proposed comprehens...Dear Editor,I am Yuki Tanaka from Hakodate Central General Hospital,Japan.Mikulicz’s disease is characterized by symmetrical swelling of lacrimal and salivary glands.In 2012,a Japanese study group proposed comprehensive diagnostic criteria for immunoglobulin G4-related disease(IgG4-RD)^([1]).They have revealed that Mikulicz’s disease is a systemic IgG4-RD and attracted attentions of ophthalmologists.In 2014,the criteria for IgG4-related ophthalmic disease(IgG4-ROD)were established.展开更多
Unidirectional carbon/carbon（C/C） composites modified with in situ grown carbon nanofibers（CNFs） were prepared by catalysis chemical vapor deposition. The effect of in situ grown CNFs on the flexural properties of...Unidirectional carbon/carbon（C/C） composites modified with in situ grown carbon nanofibers（CNFs） were prepared by catalysis chemical vapor deposition. The effect of in situ grown CNFs on the flexural properties of the C/C composites was investigated by detailed analyses of destructive process. The results show that there is a sharp increase in the flexural load-displacement curve in the axial direction of the CNF-C/C composites, followed by a serrated yielding phenomenon similar to the plastic materials. The failure mode of the C/C composites modified with in situ grown CNFs is changed from the pull-out of single fiber to the breaking of fiber bundles. The existence of interfacial layer composed by middle-textured pyrocarbon, CNFs and high-textured pyrocarbon can block the crack propagation and change the propagation direction of the main crack, which leads to the higher flexural strength and modulus of C/C composites.展开更多
This paper analyzes the destructive effect of lawlessness on Dorian Gray in The Picture of Dorian Gray and Kurtz in Heart of Darkness.Under the protection of his portrait,Dorian Gray is lost in his seeking for pleasur...This paper analyzes the destructive effect of lawlessness on Dorian Gray in The Picture of Dorian Gray and Kurtz in Heart of Darkness.Under the protection of his portrait,Dorian Gray is lost in his seeking for pleasure and corrupts from a good angel into a vicious devil.As an oppressor in Africa,Kurtz can make his law and can do anything without punishment and is thus destroyed by his insatiable desire for ivory.The corruption of Dorian Gray and Kurtz shows that without observation,man may expose his evil side to an extreme.展开更多
This paper involves a series of destructive full-scale load tests on long bored piles instrumented with strain gauges along the shafts,including two compression and two tension loading tests.The load-displacement resp...This paper involves a series of destructive full-scale load tests on long bored piles instrumented with strain gauges along the shafts,including two compression and two tension loading tests.The load-displacement response,axial force,skin friction,and the thresholds of the slip displacement for fully mobilizing the skin resistances in different soils are discussed.Moreover,the theoretical solution for estimating the pile tip settlement under compression was adopted to analyze the test results.It was found that the measured skin frictions for the piles under compression were about 6% to 42% higher than the estimated values of the cone penetration tests(CPTs),whereas the measured skin frictions in the uplift cases were about 16% to 50% smaller than the estimated values.In addition,the average limited skin frictions for the tension piles were about 0.36 to 0.78 times the average ultimate skin frictions for the piles under compression.It also can be indicated that the skin friction along the pile depth approached the limited state,and decreased from a peak value with increasing loads.展开更多
Reflection engineering plays an important role in optics.For conventional approaches,the reflection tuning is quite challenging in a loss-free component.Therefore,a simple approach to tune the reflection is highly des...Reflection engineering plays an important role in optics.For conventional approaches,the reflection tuning is quite challenging in a loss-free component.Therefore,a simple approach to tune the reflection is highly desired in plenty of applications.In this paper,we propose a new design of metasurface with just one single layer dielectric structure to tune the reflection of an interface by destructive interference in a subwavelength scale.By arranging the orientation of nano-antennas,the reflectivity tuning from 20%to 90%can be achieved at the wavelength of 1550 nm.Moreover,such reflectivity tuning of the designed metasurface works at the tunable wavelength from1500 nm to 1600 nm.This ultra-thin solution can achieve similar performance as the traditional bulky components without diffraction orders,while the design and fabrication are much simple and flexible.The ultra-thin and tunable properties indicate the great potentials of this method to be applied in laser fabrication,optical communication and optical integration.展开更多
Pulsed eddy current （PEC） non-destructive test- ing and evaluation （NDT＆E） has been around for some time and it is still attracting extensive attention from researchers around the globe, which can be witnessed th...Pulsed eddy current （PEC） non-destructive test- ing and evaluation （NDT＆E） has been around for some time and it is still attracting extensive attention from researchers around the globe, which can be witnessed through the reports reviewed in this paper. Thanks to its richness of spectral components, various applications of this technique have been proposed and reported in the lit- erature covering both structural integrity inspection and material characterization in various industrial sectors. To support its development and for better understanding of the phenomena around the transient induced eddy currents, attempts for its modelling both analytically and numeri- cally have been made by researchers around the world. This review is an attempt to capture the state-of-the-art development and applications of PEC, especially in the last 15 years and it is not intended to be exhaustive. Future challenges and opportunities for PEC NDT＆E are also presented.展开更多
There are many methods to identify and recognize the molecular and behavioural differences between organisms.One of the methods for the detection and identification of unknown organisms as well as intermolecular and i...There are many methods to identify and recognize the molecular and behavioural differences between organisms.One of the methods for the detection and identification of unknown organisms as well as intermolecular and intramolecular structural differences is MALDI-TOF mass spectrometry.Therefore,differentiation of Fomes fomentarius decay capabilities on the chemical properties of the wood cell wall of the tree species Quercus castaneifolia,Juglans regia,and Carpinus betulus were used to determine and characterize the destructive behaviour of F.fomentarius decay by MALDI-TOF mass spectrometry.The results showed that the fungus had more significant destructive behaviour on J.regia than the other species.For this evidence,completely removal of xylan hemicellulose fragment+Na+at peak 1227 Da and severe digestion of fragment of glucomannan hemicellulose at peak 1477–1480 Da that it seems that signs of soft-rot patterns were obtained from the decayed sample of J.regia,while these were incremental and unchanged for C.betulus and Q.castaneifolia,respectively.However,C.betulus had different peaks of atomic mass than J.regia and Q.castaneifolia wood,respectively.These results showed that this technique could be useful for separating and identifying unknown compounds of the wood cell wall attacked by fungi relying on their biological behaviour.展开更多
The destructive cult is an underworld gang organization with the witchcraft and anti-social characteristics, in ＂Theliving god＂, namely the gang master, as the faith. The cause of formation bases on mankind cognitiv...The destructive cult is an underworld gang organization with the witchcraft and anti-social characteristics, in ＂Theliving god＂, namely the gang master, as the faith. The cause of formation bases on mankind cognitive level andsocial environment except for artificial factors. So in any time, the destructive cult has the possibility and necessityof its existence. In paper, it emphasizes that we should strengthen scientific education, open mind and sublimationof self at the same time of improving society. In this way, can only we eliminate the influence of the cult, breakdown the foundations of the cult.展开更多
The index of casualties is introduced for the trapped that is still alive after a destructive earthquake to indicate his (her) injury degree. In order to describe the injury-developing process controlled by three fact...The index of casualties is introduced for the trapped that is still alive after a destructive earthquake to indicate his (her) injury degree. In order to describe the injury-developing process controlled by three factors: the initial injury degree, the trap surroundings and the physique of the cornered, a function SFC (State-Function of Casualties) can be naturally constructed. Through parameter analysis from eight pieces of figures, it can be found that the trapped with weaker physique and worse initial injury degree and in more adverse trap surroundings deserves sooner rescue.展开更多
The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction b...The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.展开更多
文摘To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete beams.Based on the measurement and ana-lysis of beam deflection,strain,and crack development under various loading levels during the research tests,combined with the verification coefficient indicators specified in the codes,the verification coefficients of bridges at different stages of damage can be examined.The results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test process.In the complete linear elastic stage,both the deflection and bottom strain verification coefficients comply with the specifications,indicating a good structural load-bearing capacity no longer adheres to the code’s requirements.In the non-linear stage,both coefficients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing capacity.According to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s specified range.The strain verification coefficient sourced from the compression zone at the bottom of theflange is not recommended for assessing the bridge’s load-bearing capacity.
基金supported by the National Natural Science Foundation of China(Grant Nos.U2244227,42277126 and 41977215).
文摘Air blasts induced by rock-ice avalanches are common natural phenomena known for their far-field destructive impact.In this study,remote sensing images,eyewitness videos and numerical modelling were comprehensively applied to analyze the initiation and propagation of the 2021 Chamoli avalancheinduced air blast.Our findings indicate that air blasts are observed from the avalanche source area to the Rishiganga valley,but nearly disappear in the Dhauliganga valley.The most intense air blast is concentrated on the left side of Ronti Gad valley,with maximum velocity and pressure estimated at over 70 m/s and 20 kPa,respectively.Such high pressure results in widespread tree breakage in the area.Based on the analysis of the Chamoli event,we further discussed the potential contribution of the avalanche flow regime,avalanche dynamics and geomorphology to the destructive potential of air blasts.Rapidly moved sliding mass can impart the air blast a high initial momentum,and this process will be exaggerated when the avalanche impacts valley walls at bends.However,when the rock-ice avalanche transforms into a debris-enriched flash flood,free water within the flowing mass can displace air,inhibiting the generation of air blasts.Our work offers new insights into the generation and propagation of rock-ice avalanche-induced air blasts,underscoring the importance of including this type of hazard during avalanche risk assessment in high-altitude glacial regions.
基金supported by the National Natural Science Foundation of China(42322702,42177131)。
文摘Airblasts,as one common phenomenon accompanied by rapid movements of landslides or rock/snow avalanches,commonly result in catastrophic damages and are attracting more and more scientific attention.To quantitatively analyze the intensity of airblast initiated by landslides,the Wangjiayan landslide,occurred in the Wenchuan earthquake,is selected here with the landslide propagation and airblast evolution being studied using FLUENT by introducing the Voellmy rheological law.The results reveal that:(1)For the Wangjiayan landslide,its whole travelling duration is only 12 s with its maximum velocity reaching 36 m/s at t=10 s;(2)corresponding to the landslide propagation,the maximum velocity,28 m/s,of the airblast initiated by the landslide also appears at t=10 s with its maximum pressure reaching594.8 Pa,which is equivalent to violent storm;(3)under the attack of airblast,the load suffered by buildings in the airblast zone increases to 1300 Pa at t=9.4 s and sharply decreased to-7000 Pa as the rapid decrease of the velocity of the sliding mass at t=10 s,which is seriously unfavorable for buildings and might be the key reason for the destructive collapse of buildings in the airblast zone of the Wangjiayan landslide.
基金The financial support from the Natural Science Foundation of Shandong Province (ZR2020KB003)
文摘NF_(3)is commonly used as an etching and cleaning gas in semiconductor industry,however it is a strongly greenhouse gas.Therefore,the destruction of disposal NF_(3)is an urgent task to migrate the greenhouse effect.Among the technologies for NF_(3)abatement,the destructive sorption of NF_(3)over metal oxides sorbents is an effective way.Thus,the search for a highly reactive and utilized sorbent for NF_(3)destruction is in great demand.In this work,AlOOH supported on carbon-sphere(AlOOH/CS)as precursors were synthesized hydrothermally and heat-treated to prepare the Al_(2)O_(3)sorbents.The influence of AlOOH/CS hydrothermal temperatures on the reactivity of derived Al_(2)O_(3)sorbents for NF_(3)destruction was investigated,and it is shown that the Al2O3 from AlOOH/CS hydro-thermalized at 120℃is superior to others.Subsequently,the optimized Al_(2)O_(3)was covered by Mn(OH)x to prepare Mn/Al_(2)O_(3)sorbents via changing hydrothermal temperatures and Mn loadings.The results show that the Mn/Al_(2)O_(3)sorbents are more utilized than bare Al_(2)O_(3)in NF_(3)destructive sorption due to the promotional effect of Mn_(2)O_(3)as surface layer on the fluorination of Al_(2)O_(3)as substrate,especially the optimal 5%Mn/Al2O3(160℃)exhibits a utilization percentage as high as 90.4%,and remarkably exceeds all the sorbents reported so far.These findings are beneficial to develop more efficient sorbents for the destruction of NF_(3).
基金supported by the National Natural Science Foundation of China (Nos.21906087 and 52070168)the Key R&D Plan of Zhejiang Province (No.2023C03127)the Fundamental Research Funds for the Central Universities (No.226-2022-00150).
文摘Catalytic destruction is an ascendant technology for the abatement of volatile organic compounds(VOCs)originating fromsolvent-based industrial processes.The varied composition tends to influence each VOC’s catalytic behavior in the reaction mixture.We investigated the catalytic destruction of multi-component VOCs including dichloromethane(DCM)and ethyl acetate(EA),as representatives from pharmaceutical waste gases,over co-supported HxPO_(4)-RuOx/CeO_(2) catalyst.A mutual inhibitory effect relating to concentrations because of competitive adsorption was verified in the binary VOCs oxidation and EA posed a more negative effect on DCM oxidation owing to EA’s superior adsorption capacity.Preferential adsorption of EA on acidic sites(HxPO_(4)/CeO_(2))promoted DCM activation on basic sites(O^(2−))and the dominating EA oxidation blocked DCM’s access to oxidation centers(RuOx/CeO_(2)),resulting in boosted monochloromethane yield and increased chlorine deposition for DCM oxidation.The impaired redox ability of Ru species owing to chlorine deposition in turn jeopardized deep oxidation of EA and its by-products,leading to increased gaseous by-products such as acetic acid originating fromEA pyrolysis.Notably,DCM at low concentration slightly promoted EA conversion at low temperatures with or without water,consistent with the enhanced EA adsorption in co-adsorption analyses.This was mainly due to that DCM impeded the shielding effect of hydrolysate deposition from rapid EA hydrolysis depending on the decreased acidity.Moreover,water benefited EA hydrolysis but decreased CO_(2) selectivity while the generated water derived from EA was likely to affect DCM transformation.This work may provide theoretical guidance for the promotion of applied catalysts toward industrial applications.
基金supported by the National Natural Science Foundation of China Nos.82370983,81671015(X.W.),82230030(Y.L.),82101043(S.C.)and 82370922(Y.F.)Beijing International Science and Technology Cooperation Project No.Z221100002722003(Y.L.)+4 种基金Beijing Natural Science Foundation Nos.L234017,JL23002(Y.L.),No.7242282(S.C.)and 7232217(Y.G.)Clinical Medicine Plus X-Young Scholars Project of Peking University No.PKU2024LCXQ039(Y.L.)National Program for Multidisciplinary Cooperative Treatment on Major Diseases No.PKUSSNMP-202013(X.W.)Hygiene and Health Development Scientific Research Fostering Plan of Haidian District Beijing No.HP2023-12-509001(J.Z.)Young Clinical Research Fund of the Chinese Stomatological Association No.CSA-02022-03(J.Z.).
文摘Temporomandibular joint(TMJ)disc displacement is one of the most significant subtypes of temporomandibular joint disorders,but its etiology and mechanism are poorly understood.In this study,we elucidated the mechanisms by which destruction of inflamed collagen fibrils induces alterations in the mechanical properties and positioning of the TMJ disc.By constructing a rat model of TMJ arthritis,we observed anteriorly dislocated TMJ discs with aggravated deformity in vivo from five weeks to six months after a local injection of Freund’s complete adjuvant.By mimicking inflammatory conditions with interleukin-1 beta in vitro,we observed enhanced expression of collagen-synthesis markers in primary TMJ disc cells cultured in a conventional two-dimensional environment.In contrast,three-dimensional(3D)-cultivated disc cell sheets demonstrated the disordered assembly of inflamed collagen fibrils,inappropriate arrangement,and decreased Young’s modulus.Mechanistically,inflammation-related activation of the nuclear factor kappa-B(NF-κB)pathway occurs during the progression of TMJ arthritis.NF-κB inhibition reduced the collagen fibril destruction in the inflamed disc cell sheets in vitro,and early NF-κB blockade alleviated collagen degeneration and dislocation of the TMJ discs in vivo.Therefore,the NF-κB pathway participates in the collagen remodeling in inflamed TMJ discs,offering a potential therapeutic target for disc displacement.
基金supported by the Researchers Supporting Project of King Saud University,Riyadh,Saudi Arabia,under Project RSPD2025R681。
文摘With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.However,battlefield uncertainties,such as equipment failures and enemy attacks,can impact these collaborative operations'stability and communication efficiency.To this end,we design a highly destruction-resistant air-ground cooperative resilient networking platform that aims to enhance the robustness of network communications by integrating ground vehicle information for UAV network deployment.It then incorporates the concept of virtual guiding force,enabling the UAV swarm to adaptively configure its network layout based on ground vehicle information,thereby improving network destruction resistance.Simulation results demonstrate that the UAV swarm involved in the proposed platform exhibits balanced flight energy consumption and excellent performance in network destruction resistance.
基金supported by the National Natural Science Foundation of China(No.2021YFC3200603)the Special Research Assistant Program,Chinese Academy of Sciences.
文摘Photocatalytic disinfection is an eco-friendly strategy for countering bacterial pollution in aquatic environments.Numerous strategies have been devised to facilitate the generation of reactive oxygen species(ROS)within photocatalysts,ultimately leading to the eradication of bacteria.However,the significance of the physical morphology of photocatalysts in the context of sterilization is frequently obscured,and the progress in the development of physical-chemical synergistic sterilization photocatalysts has been relatively limited.Herein,graphitic carbon nitride(g-C_(3)N_(4))is chemically protonated to expose more sharp edges.PL fluorescence and EIS results indicate that the protonation can accelerate photogenerated carrier separation and enhance ROS production.Meanwhile,the sharp edges on the protonated g-C_(3)N_(4)facilitate the physical disruption of cell walls for further promoting oxidative damage.Protonated C_(3)N_(4)demonstrated superior bactericidal performance than that of pristine g-C_(3)N_(4),effectively eliminating Escherichia coli within 40 minutes under irradiation.This work highlights the significance of incorporating physical and chemical synergies in photocatalyst design to enhance the disinfection efficiency of photocatalysis.
文摘BACKGROUND Although laparoscopic gastrolithotomy had been widely used in clinical practice,uncommon postoperative complications still require vigilance by medical staff.CASE SUMMARY Here we report a 67-year-old man who suffered for 18 months and underwent surgery several times due to a rare and undetected complication of laparoscopic gastricolithotomy.He presented to multiple hospitals because of sustained left upper quadrant abdominal pain one month after laparoscopic gastricolithotomy due to a large gastric bezoar caused by unrestrained eating of black dates and was diagnosed with possible intercostal neuritis.Many painkillers were used to relieve his symptoms but the condition progressed.Seven months after surgery,he was hospitalized as skin ulceration occurred in the left upper abdominal wall and was subsequently diagnosed with a massive thoracoabdominal wall abscess.One year after surgery,irreversible costal destruction was demonstrated.Both lesions were finally proved to be secondary damage due to a rare chronic gastro-abdominal wall fistula related to laparoscopic gastricolithotomy and the diameter of the gastric fistula reached 2 centimeters(cm).The patient was ultimately cured but underwent multi-regional incisions and drainage of the abscess,drainage of the gastric fistula,partial gastrectomy and removal of damaged ribs,and was followed-up for more than 4 years without recurrence.It is well-known that gastric fistula usually has an acute onset and occurs early after surgery,while chronic gastro-abdominal wall fistula especially with secondary massive thoracoabdominal wall abscess and costal destruction has rarely been reported.CONCLUSION This may be the first reported case of a chronic thoracoabdominal abscess and costal destruction caused by an undetected chronic gastro-abdominal wall fistula.We believe that this is a novel type of gastric fistula and the diagnosis and treatment were challenging.
文摘Dear Editor,I am Yuki Tanaka from Hakodate Central General Hospital,Japan.Mikulicz’s disease is characterized by symmetrical swelling of lacrimal and salivary glands.In 2012,a Japanese study group proposed comprehensive diagnostic criteria for immunoglobulin G4-related disease(IgG4-RD)^([1]).They have revealed that Mikulicz’s disease is a systemic IgG4-RD and attracted attentions of ophthalmologists.In 2014,the criteria for IgG4-related ophthalmic disease(IgG4-ROD)were established.
基金Project(2011CB605804)supported by the National Basic Research Program of ChinaProject(51165006)supported by the National Natural Science Foundation of China+1 种基金Project(BY2013015-32)supported by Cooperative Innovation Fund-Prospective Project of Jiangsu Province,ChinaProject(JUSRP1045)supported by the Fundamental Research Funds for the Central Universities,China
文摘Unidirectional carbon/carbon（C/C） composites modified with in situ grown carbon nanofibers（CNFs） were prepared by catalysis chemical vapor deposition. The effect of in situ grown CNFs on the flexural properties of the C/C composites was investigated by detailed analyses of destructive process. The results show that there is a sharp increase in the flexural load-displacement curve in the axial direction of the CNF-C/C composites, followed by a serrated yielding phenomenon similar to the plastic materials. The failure mode of the C/C composites modified with in situ grown CNFs is changed from the pull-out of single fiber to the breaking of fiber bundles. The existence of interfacial layer composed by middle-textured pyrocarbon, CNFs and high-textured pyrocarbon can block the crack propagation and change the propagation direction of the main crack, which leads to the higher flexural strength and modulus of C/C composites.
文摘This paper analyzes the destructive effect of lawlessness on Dorian Gray in The Picture of Dorian Gray and Kurtz in Heart of Darkness.Under the protection of his portrait,Dorian Gray is lost in his seeking for pleasure and corrupts from a good angel into a vicious devil.As an oppressor in Africa,Kurtz can make his law and can do anything without punishment and is thus destroyed by his insatiable desire for ivory.The corruption of Dorian Gray and Kurtz shows that without observation,man may expose his evil side to an extreme.
基金Project(No.51078330)supported by the National Natural Science Foundation of China
文摘This paper involves a series of destructive full-scale load tests on long bored piles instrumented with strain gauges along the shafts,including two compression and two tension loading tests.The load-displacement response,axial force,skin friction,and the thresholds of the slip displacement for fully mobilizing the skin resistances in different soils are discussed.Moreover,the theoretical solution for estimating the pile tip settlement under compression was adopted to analyze the test results.It was found that the measured skin frictions for the piles under compression were about 6% to 42% higher than the estimated values of the cone penetration tests(CPTs),whereas the measured skin frictions in the uplift cases were about 16% to 50% smaller than the estimated values.In addition,the average limited skin frictions for the tension piles were about 0.36 to 0.78 times the average ultimate skin frictions for the piles under compression.It also can be indicated that the skin friction along the pile depth approached the limited state,and decreased from a peak value with increasing loads.
基金financially supported by A*STAR, SERC 2014 Public Sector Research Funding (PSF) (Grant: SERC Project 1421200080)973 Program of China (2013CBA01700)+1 种基金Chinese Nature Science Grant (61675207)Mr.Li Yang acknowledges the support from China Scholarship Council (CSC)
文摘Reflection engineering plays an important role in optics.For conventional approaches,the reflection tuning is quite challenging in a loss-free component.Therefore,a simple approach to tune the reflection is highly desired in plenty of applications.In this paper,we propose a new design of metasurface with just one single layer dielectric structure to tune the reflection of an interface by destructive interference in a subwavelength scale.By arranging the orientation of nano-antennas,the reflectivity tuning from 20%to 90%can be achieved at the wavelength of 1550 nm.Moreover,such reflectivity tuning of the designed metasurface works at the tunable wavelength from1500 nm to 1600 nm.This ultra-thin solution can achieve similar performance as the traditional bulky components without diffraction orders,while the design and fabrication are much simple and flexible.The ultra-thin and tunable properties indicate the great potentials of this method to be applied in laser fabrication,optical communication and optical integration.
基金Ministry of Higher Education of Malaysia for funding the project on PEC NDT at IIUM through the research grant FRGS16-059-0558supported by the National Natural Science Foundation of China under research grants 51677187 and 51307172
文摘Pulsed eddy current （PEC） non-destructive test- ing and evaluation （NDT＆E） has been around for some time and it is still attracting extensive attention from researchers around the globe, which can be witnessed through the reports reviewed in this paper. Thanks to its richness of spectral components, various applications of this technique have been proposed and reported in the lit- erature covering both structural integrity inspection and material characterization in various industrial sectors. To support its development and for better understanding of the phenomena around the transient induced eddy currents, attempts for its modelling both analytically and numeri- cally have been made by researchers around the world. This review is an attempt to capture the state-of-the-art development and applications of PEC, especially in the last 15 years and it is not intended to be exhaustive. Future challenges and opportunities for PEC NDT＆E are also presented.
文摘There are many methods to identify and recognize the molecular and behavioural differences between organisms.One of the methods for the detection and identification of unknown organisms as well as intermolecular and intramolecular structural differences is MALDI-TOF mass spectrometry.Therefore,differentiation of Fomes fomentarius decay capabilities on the chemical properties of the wood cell wall of the tree species Quercus castaneifolia,Juglans regia,and Carpinus betulus were used to determine and characterize the destructive behaviour of F.fomentarius decay by MALDI-TOF mass spectrometry.The results showed that the fungus had more significant destructive behaviour on J.regia than the other species.For this evidence,completely removal of xylan hemicellulose fragment+Na+at peak 1227 Da and severe digestion of fragment of glucomannan hemicellulose at peak 1477–1480 Da that it seems that signs of soft-rot patterns were obtained from the decayed sample of J.regia,while these were incremental and unchanged for C.betulus and Q.castaneifolia,respectively.However,C.betulus had different peaks of atomic mass than J.regia and Q.castaneifolia wood,respectively.These results showed that this technique could be useful for separating and identifying unknown compounds of the wood cell wall attacked by fungi relying on their biological behaviour.
文摘The destructive cult is an underworld gang organization with the witchcraft and anti-social characteristics, in ＂Theliving god＂, namely the gang master, as the faith. The cause of formation bases on mankind cognitive level andsocial environment except for artificial factors. So in any time, the destructive cult has the possibility and necessityof its existence. In paper, it emphasizes that we should strengthen scientific education, open mind and sublimationof self at the same time of improving society. In this way, can only we eliminate the influence of the cult, breakdown the foundations of the cult.
文摘The index of casualties is introduced for the trapped that is still alive after a destructive earthquake to indicate his (her) injury degree. In order to describe the injury-developing process controlled by three factors: the initial injury degree, the trap surroundings and the physique of the cornered, a function SFC (State-Function of Casualties) can be naturally constructed. Through parameter analysis from eight pieces of figures, it can be found that the trapped with weaker physique and worse initial injury degree and in more adverse trap surroundings deserves sooner rescue.
基金supported in part by the Japan Agency for Medical Research and Development (AMED) under grant number JP20ek0410073, JP23ek0410108, JP22ek0410100, AMEDCREST under grant number JP19gm1210008 and AMED-PRIME under grant number JP21gm6310029, the AMED Japan Initiative for World leading Vaccine Research and Development Centers (JP223fa627001)Japan Society for the Promotion of Science (JSPS): Scientific Research S (21H05046), Scientific Research B (21H03104, 22H03195, and 22H02844) and Challenging Research (20K21515 and 21K18254)+3 种基金the JST FOREST Program (JPMJFR2261, JPMJFR205Z)Y.A. was supported by a JSPS Research Fellowship for Young Scientists (23KJ1949)Japanese Society for Immunology (JSI)Kibou Scholarship for Doctoral Students in Immunology。
文摘The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.
