Diazido Pt(Ⅳ)complexes with a general formula[Pt(N_(3))_(2)(L)(L’)(OR)(OR’)]are a new generation of anticancer prodrugs designed for use in photoactivated chemotherapy.The potencies of these complexes are affected ...Diazido Pt(Ⅳ)complexes with a general formula[Pt(N_(3))_(2)(L)(L’)(OR)(OR’)]are a new generation of anticancer prodrugs designed for use in photoactivated chemotherapy.The potencies of these complexes are affected by the cis/trans geometry configuration,the non-leaving ligand L/L’and derivatisation of the axial ligand OR/OR’.展开更多
基金supported by the MRC(grant G0701062)EPSRC(grants EP/G006792,EP/F034210/1,EP/P030572/1 to PJS),ERC(grant 247450 to PJS)a Chancellor’s International PhD Scholarship from the University of Warwick(for HS),and the Wellcome Trust(209173/Z/17/Z,Sir Henry Wellcome Fellowship for CI).
文摘Diazido Pt(Ⅳ)complexes with a general formula[Pt(N_(3))_(2)(L)(L’)(OR)(OR’)]are a new generation of anticancer prodrugs designed for use in photoactivated chemotherapy.The potencies of these complexes are affected by the cis/trans geometry configuration,the non-leaving ligand L/L’and derivatisation of the axial ligand OR/OR’.
