AIM:To evaluate the choroidopathy in patients with systemic lupus erythematosus(SLE)using enhanced depth imaging spectral domain optical coherence tomography(EDI SD-OCT)and optical coherence tomography angiography(OCT...AIM:To evaluate the choroidopathy in patients with systemic lupus erythematosus(SLE)using enhanced depth imaging spectral domain optical coherence tomography(EDI SD-OCT)and optical coherence tomography angiography(OCTA).METHODS:A total of 74 patients with SLE and 40 healthy volunteers were included in this cross-sectional study.SLE patients were further divided into three subgroups based on clinical and blood biochemistry findings.Ocular parameters obtained on ophthalmologic examination and optical imaging(EDI SD-OCT and OCTA)included the best corrected distance visual acuity(logMAR CDVA),subfoveal choroidal thickness(SCT),choroidal vascularity index(CVI)and vessel density(VD)of superficial capillary plexus(SCP)and deep capillary plexus(DCP).RESULTS:SLE patients had significantly lower values for CVI and VD of DCP(DVD)than control subjects.Amongst SLE patients,gender and chloroquine dose were found to be independent determinants of CVI while age predicted SCT.Steroid dose was a significant predictor for foveal VD of SCP(SVD),chloroquine dose for parafoveal SVD,gender for total DVD,and gender and steroid dose for perifoveal DVD.No correlation of logMAR CDVA and SCT was noted between SLE patients and control subjects.No correlation of SCT was noted with disease duration,Systemic Lupus Erythematosus Disease Activity Index(SLEDAI)score,hydroxychloroquine(HCQ)dose or steroid dose.No correlation of CVI was noted with patient age,disease duration,SLEDAI score,HCQ dose or steroid dose.No significant difference was noted between SLE subgroups in terms of any of the ocular parameters studied.CONCLUSION:The findings reveal the presence of ocular findings suggestive of early onset choroidopathy on EDI SD-OCT and OCTA in SLE patients,in the absence of ocular manifestations or active disease.展开更多
We study the influence of limited-view scanning on the depth imaging of photoacoustic tomography. The situation, in which absorbers are located at different depths with respect to the limited-view scanning trajectory,...We study the influence of limited-view scanning on the depth imaging of photoacoustic tomography. The situation, in which absorbers are located at different depths with respect to the limited-view scanning trajectory, is called depth imaging and is investigated in this paper. The results show that limited-view scanning causes the reconstructed intensity of deep absorbers to be weaker than that of shallow ones and that deep absorbers will be invisible if the scanning range is too small. The concept of effective scanning angle is proposed to analyse that phenomenon. We find that an effective scanning angle can well predict the relationship between scanning angle and the intensity ratio of absorbers. In addition, limited-view scanning is employed to improve image quality.展开更多
AIM：To assess peripapillary retinal nerve fiber layer（RNFL）and choroidal thickness obtained with enhanced depth imaging（EDI）mode compared with those obtained without EDI mode using Heidelberg Spectralis optical c...AIM：To assess peripapillary retinal nerve fiber layer（RNFL）and choroidal thickness obtained with enhanced depth imaging（EDI）mode compared with those obtained without EDI mode using Heidelberg Spectralis optical coherence tomography（OCT）.METHODS：Fifty eyes of 25 normal healthy subjects and32 eyes of 20 patients with different eye diseases were included in the study.All subjects underwent 3.4 mm diameter peripapillary circular OCT scan centered on the optic disc using both the conventional and the EDI OCT protocols.The visualization of RNFL and choroidoscleral junction was assessed using an ordinal scoring scale.The paired t-test,intraclass correlation coefficient（ICC）,95%limits of agreement（LoA）,and Bland and Altman plots were used to test the agreement of measurements.RESULTS：The visibility score of RNFL obtained with and without EDI was of no significant difference（P=0.532）,the visualization of choroidoscleral junction was better using EDI protocol than conventional protocol（P〈0.001）.Peripapillary RNFL thickness obtained with EDI was slightly thicker than that obtained without EDI（103.25±9.42μm vs 101.87±8.78μm,P=0.010）.The ICC of the two protocols was excellent with the value of 0.867 to 0.924,the 95%LoA of global RNFL thickness was between-10.0 to 7.4μm.Peripapillary choroidal thickness obtained with EDI was slightly thinner than that obtained without EDI（147.23±51.04μm vs 150.90±51.84μm,P〈0.001）.The ICC was also excellent with the value of 0.960 to 0.987,the 95%LoA of global choroidal thickness was between-12.5 to 19.8μm.CONCLUSION：Peripapillary circular OCT scan with or without EDI mode shows comparable results in the measurement of peripapillary RNFL and choroidal thickness.展开更多
AIM: To describe and evaluate a standardized protocol for measuring the choroidal thickness(Ch T) using enhanced depth imaging optical coherence tomography(EDI OCT).METHODS: Single 9 mm EDI OCT line scans across the f...AIM: To describe and evaluate a standardized protocol for measuring the choroidal thickness(Ch T) using enhanced depth imaging optical coherence tomography(EDI OCT).METHODS: Single 9 mm EDI OCT line scans across the fovea were used for this study. The protocol used in this study classified the EDI OCT images into four groups based on the appearance of the choroidal-scleral interface and suprachoroidal space. Two evaluation iterations of experiments were performed: first, the protocol was validated in a pilot study of 12 healthy eyes. Afterwards, the applicability of the protocol was tested in 82 eyes of patients with diabetes. Inter-observer and intra-observer agreements on image classifications were performed using Cohen’s kappa coefficient(κ). Intraclass correlation coefficient(ICC) and Bland-Altman’s methodology were used for the measurement of the Ch T.RESULTS: There was a moderate(κ=0.42) and perfect(κ =1) inter- and intra-observer agreements on image classifications from healthy eyes images and substantial(κ =0.66) and almost perfect(κ =0.86) agreements from diabetic eyes images. The proposed protocol showed excellent inter- and intra-observer agreements for the Ch T measurements on both, healthy eyes and diabetic eyes(ICC 】0.90 in all image categories). The Bland-Altman plot showed a relatively large Ch T measurement agreement in the scans that contained less visible choroidal outer boundary. CONCLUSION: A protocol to standardize Ch T measurements in EDI OCT images has been developed;the results obtained using this protocol show that the technique is accurate and reliable for routine clinical practice and research.展开更多
AIM:To characterize spectral-domain optical coherence tomography(SD-OCT)features of chorioretinal folds in orbital mass imaged using enhanced depth imaging(EDI).METHODS:Prospective observational case-control study was...AIM:To characterize spectral-domain optical coherence tomography(SD-OCT)features of chorioretinal folds in orbital mass imaged using enhanced depth imaging(EDI).METHODS:Prospective observational case-control study was conducted in 20 eyes of 20 patients,the uninvolved eye served as a control.All the patients underwent clinical fundus photography,computed tomography,EDI SDOCT imaging before and after surgery.Two patients with cavernous hemangiomas underwent intratumoral injection of bleomycin A5;the remaining patients underwent tumor excision.Patients were followed 1 to 14mo following surgery(average follow up,5.8mo).RESULTS:Visual acuity prior to surgery ranged from 20/20 to 20/200.Following surgery,5 patients’visual acuity remained unchanged while the remaining 15 patients had a mean letter improvement of 10(range 4 to 26 letters).Photoreceptor inner/outer segment defects were found in 10 of 15 patients prior to surgery.Following surgical excision,photoreceptor inner/outer segment defects fully resolved in 8 of these 10 patients.CONCLUSION:Persistence of photoreceptor inner/outer segment defects caused by compression of the globe by an orbital mass can be associated with reduced visual prognosis.Our findings suggest that photoreceptor inner/outer segment defects on EDI SD-OCT could be an indicator for immediate surgical excision of an orbital mass causing choroidal compression.展开更多
AIM：To evaluate the peripapillary choroidal thickness（PPCT） in Chinese children,and to analyze the influencing factors.METHODS： PPCT was measured with enhanced depth imaging optical coherence tomography（EDI-OCT）...AIM：To evaluate the peripapillary choroidal thickness（PPCT） in Chinese children,and to analyze the influencing factors.METHODS： PPCT was measured with enhanced depth imaging optical coherence tomography（EDI-OCT） in 70children（53 myopes and 17 non-myopes） aged 7 to 18 y,with spherical equivalent refractive errors between 0.50and-5.87 diopters（D）.Peripapillary choroidal imaging was performed using circular scans of a diameter of 3.4 mm around the optic disc.PPCT was measured by EDI-OCT in six sectors： nasal（N）,superonasal（SN）,superotemporal（ST）,temporal（T）,inferotemporal（IT）and inferonasal（IN）,as well as global RNFL thickness（G）.RESULTS： The mean global PPCT was 165.49±33.76 μm.The temporal,inferonasal,inferotemporal PPCT were significantly thinner than the nasal,superonasal,superotemporal segments PPCT were significantly thinner in the myopic group at temporal,superotemporal and inferotemporal segments.The axial length was significantly associated with the average global（β=-0.419,P =0.014）,superonasal（β=-2.009,P=0.049） and inferonasal（β=-2.000,P=0.049） PPCT.The other factors（gender,age,SE） were not significantly associated with PPCT.CONCLUSION： PPCT was thinner in the myopic group at temporal,superotemporal and inferotemporal segments.The axial length was found to be negatively correlated to PPCT.We need more further studies about the relationship between PPCT and myopia.展开更多
Hyperspectral-depth imaging is of great importance in many fields.However,it is difficult for most systems to achieve good spectral resolution and accurate location at the same time.Here,we present a hyperspectral-dep...Hyperspectral-depth imaging is of great importance in many fields.However,it is difficult for most systems to achieve good spectral resolution and accurate location at the same time.Here,we present a hyperspectral-depth single-pixel imaging system that exploits the two reflection beam paths of a spatial light modulator to provide one-dimensional depth and spectral information of the object;then,they are combined with the modulation patterns and compressed-sensing algorithm to construct the hyperspectral-depth image,even at a sampling ratio of 25%.In our experiments,a spectral resolution of 1.2 nm in the range of 420 to 780 nm is achieved,with a depth measurement error of less than 1 cm.Our work thus provides a new way for hyperspectral-depth imaging.展开更多
The effect of optical cleaning method combined with laser speckle imaging(LSI)was discussed to improve the detection depth of LSI due to high scattering characteristics of skin,which limit its clinical application.A d...The effect of optical cleaning method combined with laser speckle imaging(LSI)was discussed to improve the detection depth of LSI due to high scattering characteristics of skin,which limit its clinical application.A double-layer skin tissue model embedded with a single blood vessel was established,and the Monte Carlo method was used to simulate photon propagation under the action of light-permeating agent.808 nm semiconductor and 632.8 nm He–Ne lasers were selected to study the e®ect of optical clearing agents(OCAs)on photon deposition in tissues.Results show that the photon energy deposition density in the epidermis increases with the amount of tissue°uid replaced by OCA.Compared with glucose solution,polyethylene glycol 400(PEG 400)and glycerol can considerably increase the average penetration depth of photons in the skin tissue,thereby raising the sampling depth of the LSI.After the action of glycerol,PEG 400,and glucose,the average photon penetration depth is increased by 51.78%,51.06%,and 21.51%for 808nm,68.93%,67.94%,and 26.67%for 632.8 nm lasers,respectively.In vivo experiment by dorsal skin chamber proves that glycerol can cause a substantial decrease in blood°ow rate,whereas PEG 400 can signicantly improve the capability of light penetration without a®ecting blood velocity,which exhibits considerable potential in the monitoring of blood°ow in skin tissues.展开更多
We established a photoacoustic imaging(PAI)system that can provide variable gain at different depths.The PAI system consists of a pulsed laser with an optical parametric oscillator working at a 728 nmwavelength and an...We established a photoacoustic imaging(PAI)system that can provide variable gain at different depths.The PAI system consists of a pulsed laser with an optical parametric oscillator working at a 728 nmwavelength and an imaging-acquisition-and-processing unit with an ultrasound transducer.Avoltage-controlled attenuator was used to realize variable gain at different depths when acquiring PAI signals.The proof-of-concept imaging results for variable gain at different depths were achieved using specic phantoms.Both resolution and optical contrast obtained through the results of variable gain for a targeted depth range are better than those of constant gain for all depths.To further testify the function,we imaged the sagittal section of the body of in vivo nude mice.In addition,we imaged an absorption sample embedded in a chicken breast tissue,reaching a maximum imaging depth of4.6 cm.The results obtained using the proposed method showed better resolution and contrast than when using 50 dB gain for all depths.The depth range resolution was1 mm,and the maximum imaging depth of our system reached4.6 cm.Furthermore,blood vessels can be revealed and targeted depth range can be selected in nude mice imaging.展开更多
We propose optical experiments to study the depth of field for a thermal light lensless ghost imaging system. It is proved that the diaphragm is an important factor to influence the depth of field, and the ghost image...We propose optical experiments to study the depth of field for a thermal light lensless ghost imaging system. It is proved that the diaphragm is an important factor to influence the depth of field, and the ghost images of two detected objects with longitudinal distance less than the depth of field can be achieved simultaneously. The longitudinal coherence scale of the thermal light lensless ghost imaging determines the depth of field. Theoretical analysis can well explain the experimental results.展开更多
In order to improve depth extraction accuracy, a method using moving array lenslet technique(MALT) in pickup stage is proposed, which can decrease the depth interval caused by pixelation. In this method, the lenslet a...In order to improve depth extraction accuracy, a method using moving array lenslet technique(MALT) in pickup stage is proposed, which can decrease the depth interval caused by pixelation. In this method, the lenslet array is moved along the horizontal and vertical directions simultaneously for N times in a pitch to get N sets of elemental images. Computational integral imaging reconstruction method for MALT is taken to obtain the slice images of the 3 D scene, and the sum modulus(SMD) blur metric is taken on these slice images to achieve the depth information of the 3 D scene. Simulation and optical experiments are carried out to verify the feasibility of this method.展开更多
This paper presents a new fall detection method of etderly people in a room environment based on shape analysis of 3D depth images captured by a Kinect sensor. Depth images are pre- processed by a median filter both f...This paper presents a new fall detection method of etderly people in a room environment based on shape analysis of 3D depth images captured by a Kinect sensor. Depth images are pre- processed by a median filter both for background and target. The sithouette of moving individual in depth images is achieved by a subtraction method for background frames. The depth images are converted to disparity map, which is obtained by the horizontal and vertical projection histogram statistics. The initial floor plane information is obtained by V disparity map, and the floor ptane equation is estimated by the least square method. Shape information of human subject in depth images is analyzed by a set of moment functions. Coefficients of ellipses are calculated to determine the direction of individual The centroids of the human body are catculated and the angle between the human body and the floor plane is calculated. When both the distance from the centroids of the human body to the floor plane and the angle between the human body and the floor plane are tower than some threshotds, fall incident will be detected. Experiments with different failing direction are performed. Experimental results show that the proposed method can detect fall incidents effectively.展开更多
This paper advances a three-dimensional space interpolation method of grey / depth image sequence, which breaks free from the limit of original practical photographing route. Pictures can cruise at will in space. By u...This paper advances a three-dimensional space interpolation method of grey / depth image sequence, which breaks free from the limit of original practical photographing route. Pictures can cruise at will in space. By using space sparse sampling, great memorial capacity can be saved and reproduced scenes can be controlled. To solve time consuming and complex computations in three-dimensional interpolation algorithm, we have studied a fast and practical algorithm of scattered space lattice and that of 'Warp' algorithm with proper depth. By several simple aspects of three dimensional space interpolation, we succeed in developing some simple and practical algorithms. Some results of simulated experiments with computers have shown that the new method is absolutely feasible.展开更多
Traditional hyperspectral imaging(HI)systems are constrained by a limited depth of field(DoF),necessitating refocusing for any out-of-focus objects.This requirement not only slows down the imaging speed but also compl...Traditional hyperspectral imaging(HI)systems are constrained by a limited depth of field(DoF),necessitating refocusing for any out-of-focus objects.This requirement not only slows down the imaging speed but also complicates the system architecture.It is challenging to trade off among speed,resolution,and DoF within an ultrasimple system.While some studies have reported advancements in extending DoF,the improvements remain insufficient.To address this challenge,we propose a novel,to our knowledge,differentiable framework that integrates an extended DoF(E-DoF)wave propagation model and an achromatic hyperspectral reconstructor powered by deep learning.Through rigorous experimental validation,we have demonstrated that the compact HI system is capable of snapshot capturing of high-fidelity images with an exceptional DoF reaching approximately 5 m,marking a significant improvement of over three orders of magnitude.Additionally,the system achieves over 90%spectral accuracy without aberration,nearly doubling the accuracy performance of existing methods.An asymmetric freeform surface design is introduced for diffractive optical elements,enabling dual functionality with design freedom and E-DoF.The sparse prior conditions for spatial texture and spectral features of hyperspectral cubic data are integrated into the reconstruction network,effectively mitigating texture blurring and chromatic aberration.It foresees that the optimal strategy for achromatic E-DoF can be adopted into other optical systems such as polarization imaging and depth measurement.展开更多
Gaussian beam migration （GBM） is an effec- tive and robust depth seismic imaging method, which overcomes the disadvantage of Kirchhoff migration in imaging multiple arrivals and has no steep-dip limitation of one-wa...Gaussian beam migration （GBM） is an effec- tive and robust depth seismic imaging method, which overcomes the disadvantage of Kirchhoff migration in imaging multiple arrivals and has no steep-dip limitation of one-way wave equation migration. However, its imaging quality depends on the initial beam parameters, which can make the beam width increase and wave-front spread with the propagation of the central ray, resulting in poor migration accuracy at depth, especially for exploration areas with complex geological structures. To address this problem, we present an adaptive focused beam method for shot-domain prestack depth migration. Using the infor- mation of the input smooth velocity field, we first derive an adaptive focused parameter, which makes a seismic beam focused along the whole central ray to enhance the wave- field construction accuracy in both the shallow and deep regions. Then we introduce this parameter into the GBM, which not only improves imaging quality of deep reflectors but also makes the shallow small-scale geological struc- tures well-defined. As well, using the amplitude-preserved extrapolation operator and deconvolution imaging condi- tion, the concept of amplitude-preserved imaging has been included in our method. Typical numerical examples and the field data processing results demonstrate the validity and adaptability of our method.展开更多
AIM:To investigate changes in choroidal thickness and vascularity in keratoconus patients treated with corneal crosslinking.METHODS:This study evaluated 28 eyes of 22 patients with keratoconus who underwent corneal cr...AIM:To investigate changes in choroidal thickness and vascularity in keratoconus patients treated with corneal crosslinking.METHODS:This study evaluated 28 eyes of 22 patients with keratoconus who underwent corneal crosslinking.The choroidal thicknesses were evaluated on enhanced depth imaging optical coherence tomography at the preoperative and postoperative 3d,1,and 3mo.Choroidal thickness in the four cardinal quadrants and the fovea were evaluated.The choroidal vascularity index was also calculated.RESULTS:There was no significant difference in central choroidal thickness between the preoperative and postoperative 3d,1mo(P>0.05).There was a significant increase in the 3mo(P=0.034)and a significant decrease in the horizontal choroidal vascularity index on the postoperative 3d(P=0.014),there was no statistically significant change in vertical axes and other visits in horizontal sections(P>0.05).CONCLUSION:This study sheds light on choroidal changes in postoperative corneal crosslinking for keratoconus.While it suggests the procedure’s relative safety for submacular choroid,more extensive research is necessary to confirm these findings and their clinical significance.展开更多
Objective:As traditional techniques for microscopic identification of Chinese medicines currently lack objective and high-quality reference images,here we developed a systemic procedure to be used in microscopic ident...Objective:As traditional techniques for microscopic identification of Chinese medicines currently lack objective and high-quality reference images,here we developed a systemic procedure to be used in microscopic identification of Chinese medicines,which would lead to more objective,effective and accurate identification process.Methods:Spatholobi Caulis(Jixueteng in Chinese)was used as the specimen in the development of such procedure.Jixueteng samples were microscopically examined in bright-and dark-field microscopy.Microscopic images were obtained by regular,EDF,and image stitching techniques.Results:The microscopic images of the characteristics in pulverized Jixueteng were captured,thanks to EDF imaging and image stitching techniques which allowed the detailed and full sighting of each characteristic to be obtained simultaneously.Different layers in anatomical transverse section,including cork,phelloderm,cortex,phloem,cambium,xylem and pith,were distinctively observed.Moreover,by comparing images of bright-and dark-field microscopy,birefringent and non-birefringent components could readily be distinguished.Conclusion:With application of the developed procedure,high-definition,panoramic and microscopic images were acquired,which could be used as the reference images for microscopic identification of Chinese medicines.展开更多
For safety reasons,in the automated dispensing medicines process,robots and humans cooperate to accomplish the task of drug sorting and distribution.In this dynamic unstructured environment,such as a humanrobot collab...For safety reasons,in the automated dispensing medicines process,robots and humans cooperate to accomplish the task of drug sorting and distribution.In this dynamic unstructured environment,such as a humanrobot collaboration scenario,the safety of human,robot,and equipment in the environment is paramount.In this work,a practical and effective robot motion planning method is proposed for dynamic unstructured environments.To figure out the problems of blind zones of single depth sensor and dynamic obstacle avoidance,we first propose a method for establishing offline mapping and online fusion of multi-sensor depth images and 3D grids of the robot workspace,which is used to determine the occupation states of the 3D grids occluded by robots and obstacles and to conduct real-time estimation of the minimum distance between the robot and obstacles.Then,based on the reactive control method,the attractive and repulsive forces are calculated and transformed into robot joint velocities to avoid obstacles in real time.Finally,the robot’s dynamic obstacle avoidance ability is evaluated on an experimental platform with a UR5 robot and two KinectV2 RGB-D sensors,and the effectiveness of the proposed method is verified.展开更多
Perception and manipulation tasks for robotic manipulators involving highly-cluttered objects have become increasingly indemand for achieving a more efficient problem solving method in modern industrial environments.B...Perception and manipulation tasks for robotic manipulators involving highly-cluttered objects have become increasingly indemand for achieving a more efficient problem solving method in modern industrial environments.But,most of the available methods for performing such cluttered tasks failed in terms of performance,mainly due to inability to adapt to the change of the environment and the handled objects.Here,we propose a new,near real-time approach to suction-based grasp point estimation in a highly cluttered environment by employing an affordance-based approach.Compared to the state-of-the-art,our proposed method offers two distinctive contributions.First,we use a modified deep neural network backbone for the input of the semantic segmentation,to classify pixel elements of the input red,green,blue and depth(RGBD)channel image which is then used to produce an affordance map,a pixel-wise probability map representing the probability of a successful grasping action in those particular pixel regions.Later,we incorporate a high speed semantic segmentation to the system,which makes our solution have a lower computational time.This approach does not need to have any prior knowledge or models of the objects since it removes the step of pose estimation and object recognition entirely compared to most of the current approaches and uses an assumption to grasp first then recognize later,which makes it possible to have an object-agnostic property.The system was designed to be used for household objects,but it can be easily extended to any kind of objects provided that the right dataset is used for training the models.Experimental results show the benefit of our approach which achieves a precision of 88.83%,compared to the 83.4%precision of the current state-of-the-art.展开更多
Depth image based rendering （DIBR） is an effective approach for virtual view synthesis in free viewpoint television and 3D video.One of the important steps in DIBR is filling the holes caused by disoeclusion regions...Depth image based rendering （DIBR） is an effective approach for virtual view synthesis in free viewpoint television and 3D video.One of the important steps in DIBR is filling the holes caused by disoeclusion regions and wrong depth values.Most of the existing hole-filling methods work well in areas of low spatial activity but fail to obtain satisfactory results in high spatial activity regions.In this paper,we combine the depth based hole-filling and the adaptive recursive interpolation algorithm which is capable of handling edges passing through the missing areas.Accoring to the experimental results,we confirm that the depth based adaptive recursive interpolation algorithm can provide better rendering quality objectively and subjectively.展开更多
文摘AIM:To evaluate the choroidopathy in patients with systemic lupus erythematosus(SLE)using enhanced depth imaging spectral domain optical coherence tomography(EDI SD-OCT)and optical coherence tomography angiography(OCTA).METHODS:A total of 74 patients with SLE and 40 healthy volunteers were included in this cross-sectional study.SLE patients were further divided into three subgroups based on clinical and blood biochemistry findings.Ocular parameters obtained on ophthalmologic examination and optical imaging(EDI SD-OCT and OCTA)included the best corrected distance visual acuity(logMAR CDVA),subfoveal choroidal thickness(SCT),choroidal vascularity index(CVI)and vessel density(VD)of superficial capillary plexus(SCP)and deep capillary plexus(DCP).RESULTS:SLE patients had significantly lower values for CVI and VD of DCP(DVD)than control subjects.Amongst SLE patients,gender and chloroquine dose were found to be independent determinants of CVI while age predicted SCT.Steroid dose was a significant predictor for foveal VD of SCP(SVD),chloroquine dose for parafoveal SVD,gender for total DVD,and gender and steroid dose for perifoveal DVD.No correlation of logMAR CDVA and SCT was noted between SLE patients and control subjects.No correlation of SCT was noted with disease duration,Systemic Lupus Erythematosus Disease Activity Index(SLEDAI)score,hydroxychloroquine(HCQ)dose or steroid dose.No correlation of CVI was noted with patient age,disease duration,SLEDAI score,HCQ dose or steroid dose.No significant difference was noted between SLE subgroups in terms of any of the ocular parameters studied.CONCLUSION:The findings reveal the presence of ocular findings suggestive of early onset choroidopathy on EDI SD-OCT and OCTA in SLE patients,in the absence of ocular manifestations or active disease.
基金Project supported by the National Basic Research Program of China(Grant No.2012CB921504)the National Natural Science Foundation of China(Grant Nos.10874088,10904069,and 11028408)the Natural Science Foundation of Jiangsu Province,China(Grant No.SBK201021985)
文摘We study the influence of limited-view scanning on the depth imaging of photoacoustic tomography. The situation, in which absorbers are located at different depths with respect to the limited-view scanning trajectory, is called depth imaging and is investigated in this paper. The results show that limited-view scanning causes the reconstructed intensity of deep absorbers to be weaker than that of shallow ones and that deep absorbers will be invisible if the scanning range is too small. The concept of effective scanning angle is proposed to analyse that phenomenon. We find that an effective scanning angle can well predict the relationship between scanning angle and the intensity ratio of absorbers. In addition, limited-view scanning is employed to improve image quality.
基金Supported by Wenzhou Municipal Science and Technology Bureau(No.Y20150257)
文摘AIM：To assess peripapillary retinal nerve fiber layer（RNFL）and choroidal thickness obtained with enhanced depth imaging（EDI）mode compared with those obtained without EDI mode using Heidelberg Spectralis optical coherence tomography（OCT）.METHODS：Fifty eyes of 25 normal healthy subjects and32 eyes of 20 patients with different eye diseases were included in the study.All subjects underwent 3.4 mm diameter peripapillary circular OCT scan centered on the optic disc using both the conventional and the EDI OCT protocols.The visualization of RNFL and choroidoscleral junction was assessed using an ordinal scoring scale.The paired t-test,intraclass correlation coefficient（ICC）,95%limits of agreement（LoA）,and Bland and Altman plots were used to test the agreement of measurements.RESULTS：The visibility score of RNFL obtained with and without EDI was of no significant difference（P=0.532）,the visualization of choroidoscleral junction was better using EDI protocol than conventional protocol（P〈0.001）.Peripapillary RNFL thickness obtained with EDI was slightly thicker than that obtained without EDI（103.25±9.42μm vs 101.87±8.78μm,P=0.010）.The ICC of the two protocols was excellent with the value of 0.867 to 0.924,the 95%LoA of global RNFL thickness was between-10.0 to 7.4μm.Peripapillary choroidal thickness obtained with EDI was slightly thinner than that obtained without EDI（147.23±51.04μm vs 150.90±51.84μm,P〈0.001）.The ICC was also excellent with the value of 0.960 to 0.987,the 95%LoA of global choroidal thickness was between-12.5 to 19.8μm.CONCLUSION：Peripapillary circular OCT scan with or without EDI mode shows comparable results in the measurement of peripapillary RNFL and choroidal thickness.
基金Supported by Foundation for the Prevention of Blindness
文摘AIM: To describe and evaluate a standardized protocol for measuring the choroidal thickness(Ch T) using enhanced depth imaging optical coherence tomography(EDI OCT).METHODS: Single 9 mm EDI OCT line scans across the fovea were used for this study. The protocol used in this study classified the EDI OCT images into four groups based on the appearance of the choroidal-scleral interface and suprachoroidal space. Two evaluation iterations of experiments were performed: first, the protocol was validated in a pilot study of 12 healthy eyes. Afterwards, the applicability of the protocol was tested in 82 eyes of patients with diabetes. Inter-observer and intra-observer agreements on image classifications were performed using Cohen’s kappa coefficient(κ). Intraclass correlation coefficient(ICC) and Bland-Altman’s methodology were used for the measurement of the Ch T.RESULTS: There was a moderate(κ=0.42) and perfect(κ =1) inter- and intra-observer agreements on image classifications from healthy eyes images and substantial(κ =0.66) and almost perfect(κ =0.86) agreements from diabetic eyes images. The proposed protocol showed excellent inter- and intra-observer agreements for the Ch T measurements on both, healthy eyes and diabetic eyes(ICC 】0.90 in all image categories). The Bland-Altman plot showed a relatively large Ch T measurement agreement in the scans that contained less visible choroidal outer boundary. CONCLUSION: A protocol to standardize Ch T measurements in EDI OCT images has been developed;the results obtained using this protocol show that the technique is accurate and reliable for routine clinical practice and research.
基金Supported by National Natural Science Foundation of China(No.81300805)。
文摘AIM:To characterize spectral-domain optical coherence tomography(SD-OCT)features of chorioretinal folds in orbital mass imaged using enhanced depth imaging(EDI).METHODS:Prospective observational case-control study was conducted in 20 eyes of 20 patients,the uninvolved eye served as a control.All the patients underwent clinical fundus photography,computed tomography,EDI SDOCT imaging before and after surgery.Two patients with cavernous hemangiomas underwent intratumoral injection of bleomycin A5;the remaining patients underwent tumor excision.Patients were followed 1 to 14mo following surgery(average follow up,5.8mo).RESULTS:Visual acuity prior to surgery ranged from 20/20 to 20/200.Following surgery,5 patients’visual acuity remained unchanged while the remaining 15 patients had a mean letter improvement of 10(range 4 to 26 letters).Photoreceptor inner/outer segment defects were found in 10 of 15 patients prior to surgery.Following surgical excision,photoreceptor inner/outer segment defects fully resolved in 8 of these 10 patients.CONCLUSION:Persistence of photoreceptor inner/outer segment defects caused by compression of the globe by an orbital mass can be associated with reduced visual prognosis.Our findings suggest that photoreceptor inner/outer segment defects on EDI SD-OCT could be an indicator for immediate surgical excision of an orbital mass causing choroidal compression.
基金Supported by Major Scientific and Technological Projects in Zhejiang Province,China(No.2013c03048-3)the Science and Technology Plan Project of Wenzhou Science and Technology Bureau(No.Y20150284)Medical Scientific Research Foundation of Zhejiang Province(No.2016ZDA016)
文摘AIM：To evaluate the peripapillary choroidal thickness（PPCT） in Chinese children,and to analyze the influencing factors.METHODS： PPCT was measured with enhanced depth imaging optical coherence tomography（EDI-OCT） in 70children（53 myopes and 17 non-myopes） aged 7 to 18 y,with spherical equivalent refractive errors between 0.50and-5.87 diopters（D）.Peripapillary choroidal imaging was performed using circular scans of a diameter of 3.4 mm around the optic disc.PPCT was measured by EDI-OCT in six sectors： nasal（N）,superonasal（SN）,superotemporal（ST）,temporal（T）,inferotemporal（IT）and inferonasal（IN）,as well as global RNFL thickness（G）.RESULTS： The mean global PPCT was 165.49±33.76 μm.The temporal,inferonasal,inferotemporal PPCT were significantly thinner than the nasal,superonasal,superotemporal segments PPCT were significantly thinner in the myopic group at temporal,superotemporal and inferotemporal segments.The axial length was significantly associated with the average global（β=-0.419,P =0.014）,superonasal（β=-2.009,P=0.049） and inferonasal（β=-2.000,P=0.049） PPCT.The other factors（gender,age,SE） were not significantly associated with PPCT.CONCLUSION： PPCT was thinner in the myopic group at temporal,superotemporal and inferotemporal segments.The axial length was found to be negatively correlated to PPCT.We need more further studies about the relationship between PPCT and myopia.
文摘Hyperspectral-depth imaging is of great importance in many fields.However,it is difficult for most systems to achieve good spectral resolution and accurate location at the same time.Here,we present a hyperspectral-depth single-pixel imaging system that exploits the two reflection beam paths of a spatial light modulator to provide one-dimensional depth and spectral information of the object;then,they are combined with the modulation patterns and compressed-sensing algorithm to construct the hyperspectral-depth image,even at a sampling ratio of 25%.In our experiments,a spectral resolution of 1.2 nm in the range of 420 to 780 nm is achieved,with a depth measurement error of less than 1 cm.Our work thus provides a new way for hyperspectral-depth imaging.
基金supported by the National Natural Science Foundation of China(Grant No.51727811).
文摘The effect of optical cleaning method combined with laser speckle imaging(LSI)was discussed to improve the detection depth of LSI due to high scattering characteristics of skin,which limit its clinical application.A double-layer skin tissue model embedded with a single blood vessel was established,and the Monte Carlo method was used to simulate photon propagation under the action of light-permeating agent.808 nm semiconductor and 632.8 nm He–Ne lasers were selected to study the e®ect of optical clearing agents(OCAs)on photon deposition in tissues.Results show that the photon energy deposition density in the epidermis increases with the amount of tissue°uid replaced by OCA.Compared with glucose solution,polyethylene glycol 400(PEG 400)and glycerol can considerably increase the average penetration depth of photons in the skin tissue,thereby raising the sampling depth of the LSI.After the action of glycerol,PEG 400,and glucose,the average photon penetration depth is increased by 51.78%,51.06%,and 21.51%for 808nm,68.93%,67.94%,and 26.67%for 632.8 nm lasers,respectively.In vivo experiment by dorsal skin chamber proves that glycerol can cause a substantial decrease in blood°ow rate,whereas PEG 400 can signicantly improve the capability of light penetration without a®ecting blood velocity,which exhibits considerable potential in the monitoring of blood°ow in skin tissues.
基金the financial support fromNational Natural Science Foundation of China(NSFC)(61675113,61527808,81401539,and 31271056)Science and Technology Research Program of Shenzhen City(JSGG20150331151536448,JCYJ20160428182247170,and JCYJ20170412170255060)+1 种基金Shenzhen basic research layout project(JCYJ20160324163759208)the projects in Shenzhen Medical Engineering Laboratory For Human Auditory-equilibrium Function。
文摘We established a photoacoustic imaging(PAI)system that can provide variable gain at different depths.The PAI system consists of a pulsed laser with an optical parametric oscillator working at a 728 nmwavelength and an imaging-acquisition-and-processing unit with an ultrasound transducer.Avoltage-controlled attenuator was used to realize variable gain at different depths when acquiring PAI signals.The proof-of-concept imaging results for variable gain at different depths were achieved using specic phantoms.Both resolution and optical contrast obtained through the results of variable gain for a targeted depth range are better than those of constant gain for all depths.To further testify the function,we imaged the sagittal section of the body of in vivo nude mice.In addition,we imaged an absorption sample embedded in a chicken breast tissue,reaching a maximum imaging depth of4.6 cm.The results obtained using the proposed method showed better resolution and contrast than when using 50 dB gain for all depths.The depth range resolution was1 mm,and the maximum imaging depth of our system reached4.6 cm.Furthermore,blood vessels can be revealed and targeted depth range can be selected in nude mice imaging.
基金Supported by the Beijing Natural Science Foundation under Grant No 4133086the Fundamental Research Funds for th Central Universities under Grant No 2-9-2014-022
文摘We propose optical experiments to study the depth of field for a thermal light lensless ghost imaging system. It is proved that the diaphragm is an important factor to influence the depth of field, and the ghost images of two detected objects with longitudinal distance less than the depth of field can be achieved simultaneously. The longitudinal coherence scale of the thermal light lensless ghost imaging determines the depth of field. Theoretical analysis can well explain the experimental results.
基金supported by the National Natural Science Foundation of China(Nos.11474169 and 61675100)the Tianjin Natural Science Foundation(No.15JCYBJC16900)
文摘In order to improve depth extraction accuracy, a method using moving array lenslet technique(MALT) in pickup stage is proposed, which can decrease the depth interval caused by pixelation. In this method, the lenslet array is moved along the horizontal and vertical directions simultaneously for N times in a pitch to get N sets of elemental images. Computational integral imaging reconstruction method for MALT is taken to obtain the slice images of the 3 D scene, and the sum modulus(SMD) blur metric is taken on these slice images to achieve the depth information of the 3 D scene. Simulation and optical experiments are carried out to verify the feasibility of this method.
基金AcknowledgementsThis work is financially supported by the National Natural Science Foundation of China （61005015）, the third National Post-Doctoral Special Foundation of China （201003280）, and 2011 Shanshai city young teachers＇ subsidy scheme. The authors would like to thank the reviewers for their useful comments.
文摘This paper presents a new fall detection method of etderly people in a room environment based on shape analysis of 3D depth images captured by a Kinect sensor. Depth images are pre- processed by a median filter both for background and target. The sithouette of moving individual in depth images is achieved by a subtraction method for background frames. The depth images are converted to disparity map, which is obtained by the horizontal and vertical projection histogram statistics. The initial floor plane information is obtained by V disparity map, and the floor ptane equation is estimated by the least square method. Shape information of human subject in depth images is analyzed by a set of moment functions. Coefficients of ellipses are calculated to determine the direction of individual The centroids of the human body are catculated and the angle between the human body and the floor plane is calculated. When both the distance from the centroids of the human body to the floor plane and the angle between the human body and the floor plane are tower than some threshotds, fall incident will be detected. Experiments with different failing direction are performed. Experimental results show that the proposed method can detect fall incidents effectively.
文摘This paper advances a three-dimensional space interpolation method of grey / depth image sequence, which breaks free from the limit of original practical photographing route. Pictures can cruise at will in space. By using space sparse sampling, great memorial capacity can be saved and reproduced scenes can be controlled. To solve time consuming and complex computations in three-dimensional interpolation algorithm, we have studied a fast and practical algorithm of scattered space lattice and that of 'Warp' algorithm with proper depth. By several simple aspects of three dimensional space interpolation, we succeed in developing some simple and practical algorithms. Some results of simulated experiments with computers have shown that the new method is absolutely feasible.
基金Youth Innovation Promotion Association of the Chinese Academy of Sciences(2022246)Shanghai Sailing Program(22YF1454800,20YF145480)。
文摘Traditional hyperspectral imaging(HI)systems are constrained by a limited depth of field(DoF),necessitating refocusing for any out-of-focus objects.This requirement not only slows down the imaging speed but also complicates the system architecture.It is challenging to trade off among speed,resolution,and DoF within an ultrasimple system.While some studies have reported advancements in extending DoF,the improvements remain insufficient.To address this challenge,we propose a novel,to our knowledge,differentiable framework that integrates an extended DoF(E-DoF)wave propagation model and an achromatic hyperspectral reconstructor powered by deep learning.Through rigorous experimental validation,we have demonstrated that the compact HI system is capable of snapshot capturing of high-fidelity images with an exceptional DoF reaching approximately 5 m,marking a significant improvement of over three orders of magnitude.Additionally,the system achieves over 90%spectral accuracy without aberration,nearly doubling the accuracy performance of existing methods.An asymmetric freeform surface design is introduced for diffractive optical elements,enabling dual functionality with design freedom and E-DoF.The sparse prior conditions for spatial texture and spectral features of hyperspectral cubic data are integrated into the reconstruction network,effectively mitigating texture blurring and chromatic aberration.It foresees that the optimal strategy for achromatic E-DoF can be adopted into other optical systems such as polarization imaging and depth measurement.
文摘Gaussian beam migration （GBM） is an effec- tive and robust depth seismic imaging method, which overcomes the disadvantage of Kirchhoff migration in imaging multiple arrivals and has no steep-dip limitation of one-way wave equation migration. However, its imaging quality depends on the initial beam parameters, which can make the beam width increase and wave-front spread with the propagation of the central ray, resulting in poor migration accuracy at depth, especially for exploration areas with complex geological structures. To address this problem, we present an adaptive focused beam method for shot-domain prestack depth migration. Using the infor- mation of the input smooth velocity field, we first derive an adaptive focused parameter, which makes a seismic beam focused along the whole central ray to enhance the wave- field construction accuracy in both the shallow and deep regions. Then we introduce this parameter into the GBM, which not only improves imaging quality of deep reflectors but also makes the shallow small-scale geological struc- tures well-defined. As well, using the amplitude-preserved extrapolation operator and deconvolution imaging condi- tion, the concept of amplitude-preserved imaging has been included in our method. Typical numerical examples and the field data processing results demonstrate the validity and adaptability of our method.
文摘AIM:To investigate changes in choroidal thickness and vascularity in keratoconus patients treated with corneal crosslinking.METHODS:This study evaluated 28 eyes of 22 patients with keratoconus who underwent corneal crosslinking.The choroidal thicknesses were evaluated on enhanced depth imaging optical coherence tomography at the preoperative and postoperative 3d,1,and 3mo.Choroidal thickness in the four cardinal quadrants and the fovea were evaluated.The choroidal vascularity index was also calculated.RESULTS:There was no significant difference in central choroidal thickness between the preoperative and postoperative 3d,1mo(P>0.05).There was a significant increase in the 3mo(P=0.034)and a significant decrease in the horizontal choroidal vascularity index on the postoperative 3d(P=0.014),there was no statistically significant change in vertical axes and other visits in horizontal sections(P>0.05).CONCLUSION:This study sheds light on choroidal changes in postoperative corneal crosslinking for keratoconus.While it suggests the procedure’s relative safety for submacular choroid,more extensive research is necessary to confirm these findings and their clinical significance.
基金financially supported by National Key R&D Program of China(No.2018YFC1707900)。
文摘Objective:As traditional techniques for microscopic identification of Chinese medicines currently lack objective and high-quality reference images,here we developed a systemic procedure to be used in microscopic identification of Chinese medicines,which would lead to more objective,effective and accurate identification process.Methods:Spatholobi Caulis(Jixueteng in Chinese)was used as the specimen in the development of such procedure.Jixueteng samples were microscopically examined in bright-and dark-field microscopy.Microscopic images were obtained by regular,EDF,and image stitching techniques.Results:The microscopic images of the characteristics in pulverized Jixueteng were captured,thanks to EDF imaging and image stitching techniques which allowed the detailed and full sighting of each characteristic to be obtained simultaneously.Different layers in anatomical transverse section,including cork,phelloderm,cortex,phloem,cambium,xylem and pith,were distinctively observed.Moreover,by comparing images of bright-and dark-field microscopy,birefringent and non-birefringent components could readily be distinguished.Conclusion:With application of the developed procedure,high-definition,panoramic and microscopic images were acquired,which could be used as the reference images for microscopic identification of Chinese medicines.
基金the Interdisciplinary Program of Shanghai Jiao Tong University(No.YG2019QNA25)。
文摘For safety reasons,in the automated dispensing medicines process,robots and humans cooperate to accomplish the task of drug sorting and distribution.In this dynamic unstructured environment,such as a humanrobot collaboration scenario,the safety of human,robot,and equipment in the environment is paramount.In this work,a practical and effective robot motion planning method is proposed for dynamic unstructured environments.To figure out the problems of blind zones of single depth sensor and dynamic obstacle avoidance,we first propose a method for establishing offline mapping and online fusion of multi-sensor depth images and 3D grids of the robot workspace,which is used to determine the occupation states of the 3D grids occluded by robots and obstacles and to conduct real-time estimation of the minimum distance between the robot and obstacles.Then,based on the reactive control method,the attractive and repulsive forces are calculated and transformed into robot joint velocities to avoid obstacles in real time.Finally,the robot’s dynamic obstacle avoidance ability is evaluated on an experimental platform with a UR5 robot and two KinectV2 RGB-D sensors,and the effectiveness of the proposed method is verified.
文摘Perception and manipulation tasks for robotic manipulators involving highly-cluttered objects have become increasingly indemand for achieving a more efficient problem solving method in modern industrial environments.But,most of the available methods for performing such cluttered tasks failed in terms of performance,mainly due to inability to adapt to the change of the environment and the handled objects.Here,we propose a new,near real-time approach to suction-based grasp point estimation in a highly cluttered environment by employing an affordance-based approach.Compared to the state-of-the-art,our proposed method offers two distinctive contributions.First,we use a modified deep neural network backbone for the input of the semantic segmentation,to classify pixel elements of the input red,green,blue and depth(RGBD)channel image which is then used to produce an affordance map,a pixel-wise probability map representing the probability of a successful grasping action in those particular pixel regions.Later,we incorporate a high speed semantic segmentation to the system,which makes our solution have a lower computational time.This approach does not need to have any prior knowledge or models of the objects since it removes the step of pose estimation and object recognition entirely compared to most of the current approaches and uses an assumption to grasp first then recognize later,which makes it possible to have an object-agnostic property.The system was designed to be used for household objects,but it can be easily extended to any kind of objects provided that the right dataset is used for training the models.Experimental results show the benefit of our approach which achieves a precision of 88.83%,compared to the 83.4%precision of the current state-of-the-art.
基金The MSIP(Ministry of Science,ICT & Future Planning),Korea,under the ITRC(Information Technology Research Center)support program(NIPA-2013-H0301-13-2006)supervised by the NIPA(National IT Industry Promotion Agency)
文摘Depth image based rendering （DIBR） is an effective approach for virtual view synthesis in free viewpoint television and 3D video.One of the important steps in DIBR is filling the holes caused by disoeclusion regions and wrong depth values.Most of the existing hole-filling methods work well in areas of low spatial activity but fail to obtain satisfactory results in high spatial activity regions.In this paper,we combine the depth based hole-filling and the adaptive recursive interpolation algorithm which is capable of handling edges passing through the missing areas.Accoring to the experimental results,we confirm that the depth based adaptive recursive interpolation algorithm can provide better rendering quality objectively and subjectively.
