In this study, we fabricated a Cerenkov fiber-optic dosimeter (CFOD) without any scintillator to measure Cerenkov radiation signals owing to gamma-rays. The relative depth dose (RDD) distributions of Ir-192 HDR brachy...In this study, we fabricated a Cerenkov fiber-optic dosimeter (CFOD) without any scintillator to measure Cerenkov radiation signals owing to gamma-rays. The relative depth dose (RDD) distributions of Ir-192 HDR brachytherapy source were obtained by using the CFOD based on a subtraction method and the RDD curve was compared with the simulation result of Monte Carlo N-particle extended transport code (MCNPX). Finally, we demonstrated that the CFOD can be used to measure real-time dose information for HDR brachytherapy.展开更多
Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like phantom developed to date. This study is an investigating of percentage depth dose enhancement wi...Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like phantom developed to date. This study is an investigating of percentage depth dose enhancement within the gel medium with the use of conformal distribution gold nanoparticle as contrast agents by high atomic number material. In this work, the normoxic polymer gel dosimeter MAGICA tissue-equivalence was first theoretically verified using MCNPX Monte Carlo code and experimentally by percentage depth dose curves within the gel medium. Then gold nanoparticles (GNPs) of 50 nm diameter with different concentrations of 0.1 mM, 0.2 mM, and 0.4 mM were embedded in MAGICA gel and irradiated by 18 MV photon beam. Experimental results have shown dose increase of 10%, 2% and 4% in 0.1 mM, 0.2 mM and 0.4 mM concentrations, respectively. Simulation results had good agreement in the optimum concentration of 0.1 mM. The largest error between experimental and simulation results was equal to 9.28% stood for 0.4 mM concentration. The results showed that the optimum concentration of gold nanoparticles to achieve maximum absorbed dose in both experimental and simulation was 0.1 mM and so it can be used for clinical studies.展开更多
Thermoplastic immobilizing masks have dosimetric effects on the patient’s skin dose. The thermoplastic percentage depth dose (PDD), equivalent thickness of water for the masks and surface doses were determined. The s...Thermoplastic immobilizing masks have dosimetric effects on the patient’s skin dose. The thermoplastic percentage depth dose (PDD), equivalent thickness of water for the masks and surface doses were determined. The surface dose factors due to the thermoplastic mask was found to be 1.7949, 1.9456, 2.0563, 2.1967, 2.3827, 2.5459 and 2.6565 for field sizes of 5 × 5, 8 × 8, 10 × 10, 12 × 12, 15 × 15, 18 × 18 and 20 × 20 cm<sup>2</sup> respectively which shifted the percentage depth dose curve to lower values. The physical thermoplastic thickness was measured to be between 2.30 and 1.80 mm, and the equivalent thicknesses of water, d<sub>e</sub>, were determined to be between 1.2 and 1.00 mm. This meant that, as the mask thickness decreased, its water equivalent thickness also decreased. The presence of the mask material increased the skin dose to a factor of 1%. The thermoplastic mask factor was also found to be 0.99.展开更多
Proton beam therapy (PBRT) is an essential tool in the treatment of certain ocular tumors due to its characteristic fall-off and sharp beam parameters at critical structures. Review of clinical cases in our ocular PBR...Proton beam therapy (PBRT) is an essential tool in the treatment of certain ocular tumors due to its characteristic fall-off and sharp beam parameters at critical structures. Review of clinical cases in our ocular PBRT program identified patients with silicone oil used as an intraocular tamponade following pars plana vitrectomy for repair of retinal detachment. Patient’s eye may be filled with silicone oil prior to PBRT for an ocular tumor. The objective of this study was to extend our knowledge of the physical characteristics of proton beams in silicone oil by measuring dose within a silicone tank itself, hence better representing the surgical eye, as well as applying the range changes to EYEPLAN software to estimate clinical impact. The relevant proton beam physical parameters in silicone oil were studied using a 67.5 MeV un-modulated proton beam. The beam parameters being defined included: 1) residual range;2) peak/plateau ratio;3) full width at half maximum (FWHM) of the Bragg peak;and 4) distal penumbra. Initially, the dose uniformity of the proton beam was confirmed at 10 mm and 28 mm depth, corresponding to plateau and peak region of the Bragg peak using Gefchromic film. Once the beam was established as expected, three sets of measurements of the beam parameters were taken in: a) water (control);b) silicone-1000 oil and water;and c) silicone-1000 oil only. Central-axis depth-ionization measurements were performed in a tank (“main tank”) with a 0.1cc ionization chamber (Model IC-18, Far west) having walls made of Shonka A150 plastic. The tank was 92 mm (length) × 40 mm (height) × 40 mm (depth). The tank had a 0.13 mm thick kapton entrance window through which the proton beam was incident. The ionization chamber was always positioned in the center of the circular field of diameter 30 mm with the phantom surface at isocenter. The ionization chamber measurements were taken at defined depths in increments of 2 mm, from 0 to 35 mm. To define the effect of silicone oil on the physical characteristics of proton beam, the above-defined three sets of measurements were made. In the first run (a), the Bragg-peak measurements were made in the main tank filled with water. In the second run (b), a second smaller tank filled with 10 mm depth silicone oil was placed in front of the water tank and the measurements were repeated in water. In the third run (c), the water in the main tank was replaced with silicone oil and the measurements were repeated in silicone directly (no second tank in runs “a” and “c”). Finally, the effects of change in range on dose distribution based on the EYEPLAN®treatment planning software of patients with lesions in close proximity to the disc/macula as well as ciliary body tumors were studied. The uniformity of the radiation across the treatment volume shows that the radiation field was uniform within ± 3% at 10 mm depth and within ±4% at 28 mm depth. Parameters evaluated for the three runs (a, b, c) included: 1) residual range;2) peak/plateau ratio;3) FWHM of the Bragg curve;and 4) distal penumbra. The measured data revealed that the un-modulated Bragg peak had a penetration at the isocenter of: a) 30 mm in water;b) 31.5 mm in silicone and water;and c) 32 mm range in silicone oil. The peak/plateau ratio of the depth dose curve is 3.1:1 in all three set-ups. The FWHM is: a) 9 mm in water;b) 10 mm in silicone and water;and c) 11 mm in silicone oil. The distal penumbra (from 90% to 20%) was: a) 1.1 mm;b) 1.4 mm;and c) 2 mm. Clinical relevance of the extended distal range in silicone was studied for impact in EYEPLAN treatment software, including cases in which tumors were in close proximity to the optic disc/nerve and macula as well as cases in which anterior ciliary body tumors were treated. The potential change of range by 2 mm in silicone would impact the dose-volume histograms (DVH) importantly for the posterior structures. In ciliary body/anterior tumors, an increase in distal range in silicone could result in optic disc/macula dose and length of optic nerve treated, compared with original EYEPLAN model DVHs. The use of silicone oil as a surgical tamponade in the treatment of retinal detachments has important implications for PBRT treatment planning. In patients with intraocular silicone oil, the physical parameters of the beam should be closely examined and DVHs for posterior structures should be analyzed for potential increased doses to the macula, disc, and length of optic nerve in the field. The change in beam parameters due to silicone oil is essential to consider in treatment planning and DVH interpretation for ocular patients with posterior as well as anterior ocular tumors.展开更多
Aim: This study aims to evaluate the difference between depth data from an intraoral cone and a conventional irradiation tube calculated using a treatment planning system (TPS), and that measured using an intraoral co...Aim: This study aims to evaluate the difference between depth data from an intraoral cone and a conventional irradiation tube calculated using a treatment planning system (TPS), and that measured using an intraoral cone for electron radiotherapy. Background: A TPS is only compatible with conventional irradiation tubes. However, such systems are not suitable for determining dose distributions when a special cone is employed. Materials and Methods: Dose distributions were calculated using the beam data for mounted intraoral cones using a TPS. Then, the dose distribution by field size was calculated for a low-melting-point lead alloy using the beam data for a mounted conventional tube. The calculated data were evaluated against the measured intraoral-cone depth data based on the dose and depth differences. Results: The calculated data for the intraoral cone case did not match the measured data. However, the depth data obtained considering the field size determined for the lead alloy using the conventional tube were close to the measured values for the intraoral cone case. The difference in the depth at which the absorbed dose was 50% of the maximum value of the percentage depth dose was less than ±4 mm for the generalized Gaussian pencil beam convolution algorithm and less than ±1 mm for the electron Monte Carlo algorithm. Conclusion: It was found that the measured and calculated dose distributions were in agreement, especially when then electron Monte Carlo algorithm was used. Thus, the TPS can be employed to determine dose distributions for intraoral cone applications.展开更多
The radiation therapy is applied on around 50% of the cancer patients. As we know, before implementing a radiation treatment planning system in the clinic, the dose-calculation measurement must be validated using rigo...The radiation therapy is applied on around 50% of the cancer patients. As we know, before implementing a radiation treatment planning system in the clinic, the dose-calculation measurement must be validated using rigorous, clinically relevant criteria [1]. Percent Depth Doses (PDD), Dose Profile (DP), Open Collimator Factor (OCF) etc., are measured for all numbers of square fields for Treatment Planning System XiO, version 4.7, for 6 and 15 MV photons energies and for 15°, 30°, 45°, 60° wedge, which were employed to obtain the profiles in any depth. The measurements were conducted also for different energies of electron beam and TPS calculation algorithms.展开更多
In order to derive the linac photon spectrum accurately both the prior constrained model and the genetic algorithm GA are employed using the measured percentage depth dose PDD data and the Monte Carlo simulated monoen...In order to derive the linac photon spectrum accurately both the prior constrained model and the genetic algorithm GA are employed using the measured percentage depth dose PDD data and the Monte Carlo simulated monoenergetic PDDs where two steps are involved.First the spectrum is modeled as a prior analytical function with two parameters αand Ep optimized with the GA.Secondly the linac photon spectrum is modeled as a discretization constrained model optimized with the GA. The solved analytical function in the first step is used to generate initial solutions for the GA’s first run in this step.The method is applied to the Varian iX linear accelerator to derive the energy spectra of its 6 and 15 MV photon beams.The experimental results show that both the reconstructed spectrums and the derived PDDs with the proposed method are in good agreement with those calculated using the Monte Carlo simulation.展开更多
文摘In this study, we fabricated a Cerenkov fiber-optic dosimeter (CFOD) without any scintillator to measure Cerenkov radiation signals owing to gamma-rays. The relative depth dose (RDD) distributions of Ir-192 HDR brachytherapy source were obtained by using the CFOD based on a subtraction method and the RDD curve was compared with the simulation result of Monte Carlo N-particle extended transport code (MCNPX). Finally, we demonstrated that the CFOD can be used to measure real-time dose information for HDR brachytherapy.
文摘Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like phantom developed to date. This study is an investigating of percentage depth dose enhancement within the gel medium with the use of conformal distribution gold nanoparticle as contrast agents by high atomic number material. In this work, the normoxic polymer gel dosimeter MAGICA tissue-equivalence was first theoretically verified using MCNPX Monte Carlo code and experimentally by percentage depth dose curves within the gel medium. Then gold nanoparticles (GNPs) of 50 nm diameter with different concentrations of 0.1 mM, 0.2 mM, and 0.4 mM were embedded in MAGICA gel and irradiated by 18 MV photon beam. Experimental results have shown dose increase of 10%, 2% and 4% in 0.1 mM, 0.2 mM and 0.4 mM concentrations, respectively. Simulation results had good agreement in the optimum concentration of 0.1 mM. The largest error between experimental and simulation results was equal to 9.28% stood for 0.4 mM concentration. The results showed that the optimum concentration of gold nanoparticles to achieve maximum absorbed dose in both experimental and simulation was 0.1 mM and so it can be used for clinical studies.
文摘Thermoplastic immobilizing masks have dosimetric effects on the patient’s skin dose. The thermoplastic percentage depth dose (PDD), equivalent thickness of water for the masks and surface doses were determined. The surface dose factors due to the thermoplastic mask was found to be 1.7949, 1.9456, 2.0563, 2.1967, 2.3827, 2.5459 and 2.6565 for field sizes of 5 × 5, 8 × 8, 10 × 10, 12 × 12, 15 × 15, 18 × 18 and 20 × 20 cm<sup>2</sup> respectively which shifted the percentage depth dose curve to lower values. The physical thermoplastic thickness was measured to be between 2.30 and 1.80 mm, and the equivalent thicknesses of water, d<sub>e</sub>, were determined to be between 1.2 and 1.00 mm. This meant that, as the mask thickness decreased, its water equivalent thickness also decreased. The presence of the mask material increased the skin dose to a factor of 1%. The thermoplastic mask factor was also found to be 0.99.
文摘Proton beam therapy (PBRT) is an essential tool in the treatment of certain ocular tumors due to its characteristic fall-off and sharp beam parameters at critical structures. Review of clinical cases in our ocular PBRT program identified patients with silicone oil used as an intraocular tamponade following pars plana vitrectomy for repair of retinal detachment. Patient’s eye may be filled with silicone oil prior to PBRT for an ocular tumor. The objective of this study was to extend our knowledge of the physical characteristics of proton beams in silicone oil by measuring dose within a silicone tank itself, hence better representing the surgical eye, as well as applying the range changes to EYEPLAN software to estimate clinical impact. The relevant proton beam physical parameters in silicone oil were studied using a 67.5 MeV un-modulated proton beam. The beam parameters being defined included: 1) residual range;2) peak/plateau ratio;3) full width at half maximum (FWHM) of the Bragg peak;and 4) distal penumbra. Initially, the dose uniformity of the proton beam was confirmed at 10 mm and 28 mm depth, corresponding to plateau and peak region of the Bragg peak using Gefchromic film. Once the beam was established as expected, three sets of measurements of the beam parameters were taken in: a) water (control);b) silicone-1000 oil and water;and c) silicone-1000 oil only. Central-axis depth-ionization measurements were performed in a tank (“main tank”) with a 0.1cc ionization chamber (Model IC-18, Far west) having walls made of Shonka A150 plastic. The tank was 92 mm (length) × 40 mm (height) × 40 mm (depth). The tank had a 0.13 mm thick kapton entrance window through which the proton beam was incident. The ionization chamber was always positioned in the center of the circular field of diameter 30 mm with the phantom surface at isocenter. The ionization chamber measurements were taken at defined depths in increments of 2 mm, from 0 to 35 mm. To define the effect of silicone oil on the physical characteristics of proton beam, the above-defined three sets of measurements were made. In the first run (a), the Bragg-peak measurements were made in the main tank filled with water. In the second run (b), a second smaller tank filled with 10 mm depth silicone oil was placed in front of the water tank and the measurements were repeated in water. In the third run (c), the water in the main tank was replaced with silicone oil and the measurements were repeated in silicone directly (no second tank in runs “a” and “c”). Finally, the effects of change in range on dose distribution based on the EYEPLAN®treatment planning software of patients with lesions in close proximity to the disc/macula as well as ciliary body tumors were studied. The uniformity of the radiation across the treatment volume shows that the radiation field was uniform within ± 3% at 10 mm depth and within ±4% at 28 mm depth. Parameters evaluated for the three runs (a, b, c) included: 1) residual range;2) peak/plateau ratio;3) FWHM of the Bragg curve;and 4) distal penumbra. The measured data revealed that the un-modulated Bragg peak had a penetration at the isocenter of: a) 30 mm in water;b) 31.5 mm in silicone and water;and c) 32 mm range in silicone oil. The peak/plateau ratio of the depth dose curve is 3.1:1 in all three set-ups. The FWHM is: a) 9 mm in water;b) 10 mm in silicone and water;and c) 11 mm in silicone oil. The distal penumbra (from 90% to 20%) was: a) 1.1 mm;b) 1.4 mm;and c) 2 mm. Clinical relevance of the extended distal range in silicone was studied for impact in EYEPLAN treatment software, including cases in which tumors were in close proximity to the optic disc/nerve and macula as well as cases in which anterior ciliary body tumors were treated. The potential change of range by 2 mm in silicone would impact the dose-volume histograms (DVH) importantly for the posterior structures. In ciliary body/anterior tumors, an increase in distal range in silicone could result in optic disc/macula dose and length of optic nerve treated, compared with original EYEPLAN model DVHs. The use of silicone oil as a surgical tamponade in the treatment of retinal detachments has important implications for PBRT treatment planning. In patients with intraocular silicone oil, the physical parameters of the beam should be closely examined and DVHs for posterior structures should be analyzed for potential increased doses to the macula, disc, and length of optic nerve in the field. The change in beam parameters due to silicone oil is essential to consider in treatment planning and DVH interpretation for ocular patients with posterior as well as anterior ocular tumors.
文摘Aim: This study aims to evaluate the difference between depth data from an intraoral cone and a conventional irradiation tube calculated using a treatment planning system (TPS), and that measured using an intraoral cone for electron radiotherapy. Background: A TPS is only compatible with conventional irradiation tubes. However, such systems are not suitable for determining dose distributions when a special cone is employed. Materials and Methods: Dose distributions were calculated using the beam data for mounted intraoral cones using a TPS. Then, the dose distribution by field size was calculated for a low-melting-point lead alloy using the beam data for a mounted conventional tube. The calculated data were evaluated against the measured intraoral-cone depth data based on the dose and depth differences. Results: The calculated data for the intraoral cone case did not match the measured data. However, the depth data obtained considering the field size determined for the lead alloy using the conventional tube were close to the measured values for the intraoral cone case. The difference in the depth at which the absorbed dose was 50% of the maximum value of the percentage depth dose was less than ±4 mm for the generalized Gaussian pencil beam convolution algorithm and less than ±1 mm for the electron Monte Carlo algorithm. Conclusion: It was found that the measured and calculated dose distributions were in agreement, especially when then electron Monte Carlo algorithm was used. Thus, the TPS can be employed to determine dose distributions for intraoral cone applications.
文摘The radiation therapy is applied on around 50% of the cancer patients. As we know, before implementing a radiation treatment planning system in the clinic, the dose-calculation measurement must be validated using rigorous, clinically relevant criteria [1]. Percent Depth Doses (PDD), Dose Profile (DP), Open Collimator Factor (OCF) etc., are measured for all numbers of square fields for Treatment Planning System XiO, version 4.7, for 6 and 15 MV photons energies and for 15°, 30°, 45°, 60° wedge, which were employed to obtain the profiles in any depth. The measurements were conducted also for different energies of electron beam and TPS calculation algorithms.
文摘In order to derive the linac photon spectrum accurately both the prior constrained model and the genetic algorithm GA are employed using the measured percentage depth dose PDD data and the Monte Carlo simulated monoenergetic PDDs where two steps are involved.First the spectrum is modeled as a prior analytical function with two parameters αand Ep optimized with the GA.Secondly the linac photon spectrum is modeled as a discretization constrained model optimized with the GA. The solved analytical function in the first step is used to generate initial solutions for the GA’s first run in this step.The method is applied to the Varian iX linear accelerator to derive the energy spectra of its 6 and 15 MV photon beams.The experimental results show that both the reconstructed spectrums and the derived PDDs with the proposed method are in good agreement with those calculated using the Monte Carlo simulation.
