Background:Pulmonary deportation of hydatidiform mole is an exceedingly rare entity.The underlying mechanisms and proper management strategies remain unclear based on sporadic case reports over the past six decades.Th...Background:Pulmonary deportation of hydatidiform mole is an exceedingly rare entity.The underlying mechanisms and proper management strategies remain unclear based on sporadic case reports over the past six decades.This study aimed to investigate the clinical features and rational treatment of patients with benign molar pregnancies with pulmonary deportation based on our experience.Methods:Medical records of 20 cases of hydatidiform mole with pulmonary deportation were retrospectively reviewed at Peking Union Medical College Hospital from November 2006 to May 2019.The detailed information of all patients was recorded and analyzed.Patients were divided into different groups according to their characteristics and Mann-Whitney U test was used to compare the duration to achieve a normal b-human chorionic gonadotrophin(b-hCG)level after the first evacuation among groups.Results:Initial pulmonary computed tomography scans showed suspected bilateral,left and right chest deportation of hydatidiform mole in 12,four,and four patients,respectively,with the maximum nodular diameter ranging from 0.6 to 1.2 cm.Ten patients achieved lesion resolution while the remaining ten patients achieved decreases in the size of their pulmonary lesions.The median duration to achieve a normal b-hCG level after the first evacuation was 15.5(13.0,21.9)weeks.There was no significant difference in the duration to achieve a normal b-hCG level after the first evacuation between two groups based on age(≥40 years vs.<40 years:15.8[12.2,21.5]weeks vs.15.5[12.9,23.0]weeks,Z=0.094,P=0.925),type of antecedent mole(partial mole vs.complete mole:15.2[12.5,27.4]weeks vs.15.9[12.9,21.5]weeks,Z=0.165,P=0.869),distribution of pulmonary nodules(bilateral lungs vs.unilateral lung:15.2[12.8,22.5]weeks vs.15.9[13.2,22.2]weeks,Z=0.386,P=0.700),maximum size of pulmonary nodules(>0.5 cm vs.0.5 cm:13.0[11.3,17.2]weeks vs.16.0[14.5,23.8]weeks,Z=1.815,P=0.070),and number of uterine evacuations(once vs.twice or three times:15.0[13.0,16.3]weeks vs.16.0[12.8,23.9]weeks,Z=0.832,P=0.405).The post-molar cohort was followed up for 17 to 139 months,and no gestational trophoblastic neoplasia was observed.Conclusions:No surgeries other than uterine evacuation and no chemotherapy regimens are recommended for such patients if they achieve satisfactory decreases in the level of hCG and gradual decrease or disappearance of pulmonary deportation nodules.Patients should be informed about the necessity of long-term follow-up.More collaborative international studies on this exceedingly rare condition may guide decisions regarding optimal management strategies.展开更多
A stable and efficient oxygen evolution reaction(OER)electrocatalyst in acidic medium is strongly required for the industrialization of polymer electrolyte membrane water splitting(PEMWS)technology.Herein,we devise th...A stable and efficient oxygen evolution reaction(OER)electrocatalyst in acidic medium is strongly required for the industrialization of polymer electrolyte membrane water splitting(PEMWS)technology.Herein,we devise the formation of nanoneedle-like RuO_(2)/V_(2)O_(5)heterostructure with the template of MIL 88B.The incorporation of V_(2)O_(5)to RuO_(2)significantly increases the deprotonation capability resulting in a better OER performance demanding 216mV overpotential at 10 mA/cm^(2),lowered by 27mV with relative to benchmarked RuO_(2).Moreover,the electronic interplay between RuO_(2)and V_(2)O_(5)contributes to an increment in oxidation of Ru to high valance state;thereby,a robust stability is achieved for RuO_(2)/V_(2)O_(5).From the theoretical calculation,it is noticed that the d band center of Ru is downshifted after V_(2)O_(5)decoration;moreover,the e_(g)filling of Ru is simultaneously increased;in this regard,the adsorption of OH^(∗)specie is weakened,in accordance to methanol detection,resulting in a higher OER performance.展开更多
基金Supported by a grant from the Chinese Academy of Medical Sciences Initiative for Innovative Medicine(No.CAMS-2017-I2M-1-002).
文摘Background:Pulmonary deportation of hydatidiform mole is an exceedingly rare entity.The underlying mechanisms and proper management strategies remain unclear based on sporadic case reports over the past six decades.This study aimed to investigate the clinical features and rational treatment of patients with benign molar pregnancies with pulmonary deportation based on our experience.Methods:Medical records of 20 cases of hydatidiform mole with pulmonary deportation were retrospectively reviewed at Peking Union Medical College Hospital from November 2006 to May 2019.The detailed information of all patients was recorded and analyzed.Patients were divided into different groups according to their characteristics and Mann-Whitney U test was used to compare the duration to achieve a normal b-human chorionic gonadotrophin(b-hCG)level after the first evacuation among groups.Results:Initial pulmonary computed tomography scans showed suspected bilateral,left and right chest deportation of hydatidiform mole in 12,four,and four patients,respectively,with the maximum nodular diameter ranging from 0.6 to 1.2 cm.Ten patients achieved lesion resolution while the remaining ten patients achieved decreases in the size of their pulmonary lesions.The median duration to achieve a normal b-hCG level after the first evacuation was 15.5(13.0,21.9)weeks.There was no significant difference in the duration to achieve a normal b-hCG level after the first evacuation between two groups based on age(≥40 years vs.<40 years:15.8[12.2,21.5]weeks vs.15.5[12.9,23.0]weeks,Z=0.094,P=0.925),type of antecedent mole(partial mole vs.complete mole:15.2[12.5,27.4]weeks vs.15.9[12.9,21.5]weeks,Z=0.165,P=0.869),distribution of pulmonary nodules(bilateral lungs vs.unilateral lung:15.2[12.8,22.5]weeks vs.15.9[13.2,22.2]weeks,Z=0.386,P=0.700),maximum size of pulmonary nodules(>0.5 cm vs.0.5 cm:13.0[11.3,17.2]weeks vs.16.0[14.5,23.8]weeks,Z=1.815,P=0.070),and number of uterine evacuations(once vs.twice or three times:15.0[13.0,16.3]weeks vs.16.0[12.8,23.9]weeks,Z=0.832,P=0.405).The post-molar cohort was followed up for 17 to 139 months,and no gestational trophoblastic neoplasia was observed.Conclusions:No surgeries other than uterine evacuation and no chemotherapy regimens are recommended for such patients if they achieve satisfactory decreases in the level of hCG and gradual decrease or disappearance of pulmonary deportation nodules.Patients should be informed about the necessity of long-term follow-up.More collaborative international studies on this exceedingly rare condition may guide decisions regarding optimal management strategies.
基金supported by the National Natural Science Foundation of China(No.22209126)the Opening Project of Key Laboratory of Optoelectronic Chemical Materials and Devices,Ministry of Education,Jianghan University(No.JDGD-202314)。
文摘A stable and efficient oxygen evolution reaction(OER)electrocatalyst in acidic medium is strongly required for the industrialization of polymer electrolyte membrane water splitting(PEMWS)technology.Herein,we devise the formation of nanoneedle-like RuO_(2)/V_(2)O_(5)heterostructure with the template of MIL 88B.The incorporation of V_(2)O_(5)to RuO_(2)significantly increases the deprotonation capability resulting in a better OER performance demanding 216mV overpotential at 10 mA/cm^(2),lowered by 27mV with relative to benchmarked RuO_(2).Moreover,the electronic interplay between RuO_(2)and V_(2)O_(5)contributes to an increment in oxidation of Ru to high valance state;thereby,a robust stability is achieved for RuO_(2)/V_(2)O_(5).From the theoretical calculation,it is noticed that the d band center of Ru is downshifted after V_(2)O_(5)decoration;moreover,the e_(g)filling of Ru is simultaneously increased;in this regard,the adsorption of OH^(∗)specie is weakened,in accordance to methanol detection,resulting in a higher OER performance.
