Primary cilia function as critical sensory organelles that mediate multiple signaling pathways,including the Hedgehog(Hh)pathway,which is essential for organ patterning and morphogenesis.Disruptions in Hh signaling ha...Primary cilia function as critical sensory organelles that mediate multiple signaling pathways,including the Hedgehog(Hh)pathway,which is essential for organ patterning and morphogenesis.Disruptions in Hh signaling have been implicated in supernumerary tooth formation and molar fusion in mutant mice.Cilk1,a highly conserved serine/threonine-protein kinase localized within primary cilia,plays a critical role in ciliary transport.Loss of Cilk1 results in severe ciliopathy phenotypes,including polydactyly,edema,and cleft palate.However,the role of Cilk1 in tooth development remains unexplored.In this study,we investigated the role of Cilk1 in tooth development.Cilk1 was found to be expressed in both the epithelial and mesenchymal compartments of developing molars.Cilk1 deficiency resulted in altered ciliary dynamics,characterized by reduced frequency and increased length,accompanied by downregulation of Hh target genes,such as Ptch1 and Sostdc1,leading to the formation of diastemal supernumerary teeth.Furthermore,in Cilk1^(-/-);PCS1–MRCS1^(△/△)mice,which exhibit a compounded suppression of Hh signaling,we uncovered a novel phenomenon:diastemal supernumerary teeth can be larger than first molars.Based on these findings,we propose a progressive model linking Hh signaling levels to sequential changes in tooth patterning:initially inducing diastemal supernumerary teeth,then enlarging them,and ultimately leading to molar fusion.This study reveals a previously unrecognized role of Cilk1 in controlling tooth morphology via Hh signaling and highlights how Hh signaling levels shape tooth patterning in a gradient-dependent manner.展开更多
For a one-dimensional conservative system with position depending mass, one deduces consistently a constant of motion, a Lagrangian, and a Hamiltonian for the nonrelativistic case. With these functions, one shows the ...For a one-dimensional conservative system with position depending mass, one deduces consistently a constant of motion, a Lagrangian, and a Hamiltonian for the nonrelativistic case. With these functions, one shows the trajectories on the spaces (x,v) and (x,p) for a linear position depending mass. For the relativistic case, the Lagrangian and Hamiltonian cannot be given explicitly in general. However, we study the particular system with constant force and mass linear dependence on the position where the Lagrangian can be found explicitly, but the Hamiltonian remains implicit in the constant of motion.展开更多
The panicle size has a strong impact on the interactions between nanoparticles and cells. However, the synthesis process of nanoparticles limits the range of achievable average panicle sizes. When biocompatible hydrox...The panicle size has a strong impact on the interactions between nanoparticles and cells. However, the synthesis process of nanoparticles limits the range of achievable average panicle sizes. When biocompatible hydroxyapatite nanoparticles （HAP） are doped with the luminescent rare earth elemeat Europium （Eu）, the panicle size becomes larger compared to pure HAP. Hence, a panicle size reduction is necessary to achieve similar experimental conditions when stbstituting pure HAP with luminescent HAP ： Eu nanoparticles to investigate particlecell-interactions in cell culture experiments. While the sedimentation process of particles in liquids and gels has been well described in literature, the separation of particles in dispersed colloids has not been studied, yet. In this study, the size depending separation and particle size redaction of a homogeneous dispersed nanoparticle sol by gravity and centrifugation were investigated. As the results showed, shorter time of centrifugation at higher speed can reduce the average particle size compared to the decline of the panicle concentation in the upper sol layer most efficiently. This ceatrifugation method has some similarity to the overspeeding technique which is commonly used to lower the transient time to reach the equilibrium of sedimentation.展开更多
To describe the energy-dependent characteristics of the reaction-subdiffusion process, we analyze the simple reaction A--→B under subdiffsion with waiting time depending on the preceding jump length, and derive the c...To describe the energy-dependent characteristics of the reaction-subdiffusion process, we analyze the simple reaction A--→B under subdiffsion with waiting time depending on the preceding jump length, and derive the corresponding master equations in the Fourier Laplace space for the distribution of A and B particles in a continuous time random walk scheme. Moreover, the generalizations of the reaction-diffusion equation for the Gaussian jump length with the probability density function of waiting time being quadratically dependent on the preceding jump length are obtained by applying the derived master equations.展开更多
We study the classical dynamics of binary stars when there is an interchange of mass between them. Assuming that one of the stars is more massive than others, the dynamics of the lighter one is analyzed as a function ...We study the classical dynamics of binary stars when there is an interchange of mass between them. Assuming that one of the stars is more massive than others, the dynamics of the lighter one is analyzed as a function of its time depending mass variation. Within our approximations and models for mass transference, we obtain a general result which establishes that if the lightest star looses mass, its period increases. If the lightest star wins mass, its period decreases.展开更多
The relocity and sirain-rate .field which are different from Avilzur's have beenestablished in Caitesian coordinates. Using the integral as a function of the upper limitand integration depending on a parameler, an...The relocity and sirain-rate .field which are different from Avilzur's have beenestablished in Caitesian coordinates. Using the integral as a function of the upper limitand integration depending on a parameler, an analylical upper-bound solution todrawing stress through idling rolls has been obtained in this paper.展开更多
Forl a 1-D conservative system with a position depending mass within a dissipative medium, its effect on the body is to exert a force depending on the squared of its velocity, a constant of motion, Lagrangian, general...Forl a 1-D conservative system with a position depending mass within a dissipative medium, its effect on the body is to exert a force depending on the squared of its velocity, a constant of motion, Lagrangian, generalized linear momentum, and Hamiltonian are obtained. We apply these new results to the harmonic oscillator and pendulum under the characteristics mentioned about, obtaining their constant of motion, Lagrangian and Hamiltonian for the case when the body is increasing its mass.展开更多
Somalia＇s rebirth relies greatly on the return of its many refugees MOGADISHU is on the mend and on the rise.A booming construction industry is building high-rise blocks that compete for skyline dominance,shops are o...Somalia＇s rebirth relies greatly on the return of its many refugees MOGADISHU is on the mend and on the rise.A booming construction industry is building high-rise blocks that compete for skyline dominance,shops are opening up at a much faster rate than two years earlier and airlines are launching routes to what has hitherto been considered the world＇s most dangerous city. Despite a rise in the number of ambushes,assassinations and suicide bombings in the city in August,a sign that Somali militant group Al-Shabaab has renewed its campaign to bring instability to the nation＇s capital,a sense of optimism still abounds as the country slowly makes its way back into the international arena.The United Kingdom has reopened its embassy after a 22-year closure.展开更多
Au/Zn O/n-type Si device is obtained using atomic layer deposition（ALD） for Zn O layer, and some main electrical parameters are investigated, such as surface/interface state（Nss）, barrier height（Φb）, series res...Au/Zn O/n-type Si device is obtained using atomic layer deposition（ALD） for Zn O layer, and some main electrical parameters are investigated, such as surface/interface state（Nss）, barrier height（Φb）, series resistance（Rs）, donor concentration（Nd）, and dielectric characterization depending on frequency or voltage. These parameters are acquired by use of impedance spectroscopy measurements at frequencies ranging from 10 k Hz to 1 MHz and the direct current（DC） bias voltages in a range from-2 V to ＋2 V at room temperature are used. The main electrical parameters and dielectric parameters,such as dielectric constant（ε＂）, dielectric loss（ε＂）, loss tangent（tan δ）, the real and imaginary parts of electric modulus（M and M）, and alternating current（AC） electrical conductivity（σ） are affected by changing voltage and frequency. The characterizations show that some main electrical parameters usually decrease with increasing frequency because charge carriers at surface states have not enough time to fallow an external AC signal at high frequencies, and all dielectric parameters strongly depend on the voltage and frequency especially in the depletion and accumulation regions. Consequently, it can be concluded that interfacial polarization and interface charges can easily follow AC signal at low frequencies.展开更多
A series of blue and blue‑green Ir(Ⅲ)complexes has been investigated theoretically to explore their electronic structures,photophysical properties,efficiency roll‑off effect,and thermal activation delayed fluorescenc...A series of blue and blue‑green Ir(Ⅲ)complexes has been investigated theoretically to explore their electronic structures,photophysical properties,efficiency roll‑off effect,and thermal activation delayed fluorescence(TADF)properties.All calculations were performed using density functional theory(DFT)and time‑dependent density functional theory(TDDFT).Calculations for electronic structures,frontier molecular orbital characteristics(which determine the efficiency roll‑off effect of the complexes),and photophysical properties were conducted using the Gaussian 09 software package.The calculation of spin‑orbit coupling matrix elements<T|HSOC|S>,which determine the TADF properties of the complexes,was performed using the ORCA software package.The calculation results show that the auxiliary ligand tetraphenylimidodiphosphinate(tpip),a strong electron‑withdrawing group,can mitigate the efficiency roll‑off effect of the complex.Furthermore,TADF is observed in one of the designed complexes,(F_(3)Phppy)_(2)Ir(tpip),where F_(3)Phppy=2‑[4‑(2,4,6‑trifluorophenyl)phenyl]pyridine.展开更多
Background:This study aims to investigate the underlying mechanisms between parental marital conflict and adolescent short video dependence by constructing a chain mediation model,focusing on the mediating roles of ex...Background:This study aims to investigate the underlying mechanisms between parental marital conflict and adolescent short video dependence by constructing a chain mediation model,focusing on the mediating roles of experiential avoidance and emotional disturbance(anxiety,depression,and stress).Methods:Conducted in January 2025,the research recruited 4125 adolescents from multiple Chinese provinces through convenience sampling;after data cleaning,3957 valid participants(1959 males,1998 females)were included.Using a cross-sectional design,measures included parental marital conflict,experiential avoidance,anxiety,depression,stress,and short video dependence.Results:Pearson correlation analysis revealed significant positive correlations among all variables.Mediation analysis using the SPSS PROCESS macro showed that parental marital conflict directly predicted short video dependence(β=0.269,p<0.001),and also significantly predicted experiential avoidance(β=0.519,p<0.001),anxiety(β=0.072,p<0.001),depression(β=0.067,p<0.001),and stress(β=0.048,p<0.05).Experiential avoidance further predicted anxiety(β=0.521,p<0.001),depression(β=0.489,p<0.001),stress(β=0.408,p<0.001),and short video dependence(β=0.244,p<0.001).While both anxiety(β=0.050,p<0.05)and depression(β=0.116,p<0.001)positively predicted short video dependence,stress did not(β=0.019,p=0.257).Overall,experiential avoidance,anxiety,depression,and stress significantly mediated the relationship between parental marital conflict and short video dependence.Conclusion:These findings confirm that parental marital conflict not only directly influences adolescent short video dependence but also operates through a chain mediation pathway involving experiential avoidance and emotional disturbance,highlighting central psychological mechanisms and providing theoretical support for integrated mental health and behavioral interventions.展开更多
Conglomerate rock's complex and heterogeneous microstructure significantly affects its mechanical properties,especially under dynamic loading.However,research on their dynamic behavior and fracture mechanisms is l...Conglomerate rock's complex and heterogeneous microstructure significantly affects its mechanical properties,especially under dynamic loading.However,research on their dynamic behavior and fracture mechanisms is limited.Through uniaxial compression tests and split Hopkinson pressure bar(SHPB)impact tests,the dynamic compressive mechanical properties and fracture mechanisms of conglomerate rock were studied.Nanoindentation and high-resolution X-ray computed tomography were employed to analyze the micro-mechanical behavior and internal structure of the conglomerate rock.Results indicate significant differences in mechanical properties between different gravel particles and cementing materials,with initial fractures primarily distributed at the gravel-cement interfaces.The dynamic mechanical properties of conglomerate rocks exhibit a clear strain rate dependency.Based on the stress−strain curves and failure characteristics,the dynamic compressive mechanical behavior can be categorized into two types using a critical strain rate.The dynamic compressive strength,peak strain,and toughness of conglomerate rock increased with the strain rate,with the strength at 54 s−1 being 2.6 times that at 6 s−1.The dynamic compressive fracture mechanism of conglomerate rock is related to the strain rate and microstructure;at low strain rates,gravel distribution is the key factor,whereas at high strain rates,gravel content becomes critical.展开更多
Objective:The aging population is growing rapidly,leading to a rise in chronic diseases and placing significant physical,emotional,and financial strain on caregivers.Managing chronic conditions alongside caregiving re...Objective:The aging population is growing rapidly,leading to a rise in chronic diseases and placing significant physical,emotional,and financial strain on caregivers.Managing chronic conditions alongside caregiving responsibilities often results in burnout,adding to the burden on caregivers.This issue also affects society and healthcare systems through increased costs and greater demands for support services.Understanding the factors contributing to caregiver burden is crucial for creating effective interventions to address these challenges.The aim of this study is to describe the extent of caregiver burden and identify some factors related to burden among caregivers of chronically ill elderly people.By gaining insight into these relationships,this study seeks to identify strategies to reduce the burden on caregivers.Methods:This study utilized a cross-sectional design to examine caregivers of the elderly with chronic diseases receiving treatment in the public healthcare facility.Data collection involved administering structured questionnaires that gathered information on the demographic characteristics of both the elderly and their caregivers,the level of social support received,the functional status of patients as measured by daily activity indices,and the level of caregiver burden.Description was used to elaborate the characteristics of participants.Mann-Whitney,Kruskal-Wallis,and Spearman's correlation test were applied to explore the relationship between variables.Statistical significance was determined at P value<0.05.Results:Caregivers of the elderly with chronic diseases had a moderate care burden score(22.62±11.24,CI:95%).The patients'level of dependence,relationship with the patients,and time spent as a caregiver were factors related to caregiver burden(P<0.05).Conclusions:Those who care for elderly people with chronic diseases suffered great burden.The finding had found a number of factors that influence the caregivers'weight loss.Healthcare providers should consider these relevant factors when developing intervention plans to reduce caregiver burden.展开更多
Directional three-dimensional carbon-based foams are emerging as highly attractive candidates for promising electromagnetic wave absorbing materials(EWAMs)thanks to their unique architecture,but their construction usu...Directional three-dimensional carbon-based foams are emerging as highly attractive candidates for promising electromagnetic wave absorbing materials(EWAMs)thanks to their unique architecture,but their construction usually involves complex procedures and extremely depends on unidirectional freezing technique.Herein,we propose a groundbreaking approach that leverages the assemblies of salting-out protein induced by ammonium metatungstate(AM)as the precursor,and then acquire directional three-dimensional carbon-based foams through simple pyrolysis.The electrostatic interaction between AM and protein ensures well dispersion of WC_(1−x)nanoparticles on carbon frameworks.The content of WC_(1−x)nanoparticles can be rationally regulated by AM dosage,and it also affects the electromagnetic(EM)properties of final carbon-based foams.The optimized foam exhibits exceptional EM absorption performance,achieving a remarkable minimum reflection loss of−72.0 dB and an effective absorption bandwidth of 6.3 GHz when EM wave propagates parallel to the directional pores.Such performance benefits from the synergistic effects of macroporous architecture and compositional design.Although there is a directional dependence of EM absorption,radar stealth simulation demonstrates that these foams can still promise considerable reduction in radar cross section with the change of incident angle.Moreover,COMSOL simulation further identifies their good performance in preventing EM interference among different electronic components.展开更多
Distributions of nuclear magnetic resonance(NMR)relaxation times provide detailed information about the water in wood.This study documents the water dynamics analysis of T_(2)and T_(1)distributions for saturated delig...Distributions of nuclear magnetic resonance(NMR)relaxation times provide detailed information about the water in wood.This study documents the water dynamics analysis of T_(2)and T_(1)distributions for saturated delignified sapwood(DSW),delignified heartwood(DHW)and lignocellulose(LC)samples at different temperatures.Results indicate that below the freezing point of bulk water,free water freezes,causing its signal to disappear from the distribution.Then,the low temperature distributions of the unfrozen bound water contain more information about its components,with DSW,DHW and LC containing two distinct states of bound water(OH bound water(B-water)and more freely bound water(C-water)).Furthermore,it was observed that within the temperature range of−3°C to−60°C,B-water in DSW,DHW and LC maintained a higher unfrozen water content(UWC)value than C-water,and the T_(1)/T_(2)ratios for B-water were consistently higher than that for C-water,indicating that B-water has a greater antifreeze capacity.T_(2)and T_(1)distributions offer different kinds of information about water components,and all peaks within the distribution have been assigned.展开更多
The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alon...The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alone and UV-LED/H_(2)O_(2) system as their complex interactions.Tetracycline(TC)degradation efficiency(kF)correlated closely with its UV molar absorbance(R^(2)=0.831)in UV-LED alone system and with·OH yield(R^(2)=0.999)in UV-LED/H_(2)O_(2) system across studied wavelengths(265,280 and 310 nm).The kF values for intracellular DNA(i-ARGs)also exhibited a high correlation with UV-LED wavelengths in both systems(R^(2)=0.997-0.999).The coexistence of TC and ARB/ARGs resulted in a mutual inhibition of their degradation efficiencies due to competition for photons and·OH,along with the consequent reduction in intracellular ROS within ARB,with their degradation efficiencies exhibiting marked dependence on wavelength in both systems.Notably,the UV-LED/H_(2)O_(2) system at 265 nm effectively achieved the simultaneous removal of TC,ARB and ARGs with minimal energy consumption,and successfully fragmented ARGs.The degradation pathway of TC was analyzed,and the biotoxicity of its degradation intermediates demonstrated the environmental friendliness and safety of UV-LED/H_(2)O_(2) technology.This study elucidated the competitive interactions between antibiotics and ARB/ARGs within UV-LED/H_(2)O_(2) system,providing a promising approach for their simultaneous removal while ensuring energy efficiency.展开更多
When performing English-to-Tamil Neural Machine Translation(NMT),end users face several challenges due to Tamil's rich morphology,free word order,and limited annotated corpora.Although available transformer-based ...When performing English-to-Tamil Neural Machine Translation(NMT),end users face several challenges due to Tamil's rich morphology,free word order,and limited annotated corpora.Although available transformer-based models offer strong baselines,they compromise syntactic awareness and the detection and man-agement of offensive content in cluttered,noisy,and informal text.In this paper,we present POSDEP-Offense-Trans,a multi-task NMT framework that combines Part-of-Speech(POS)and Dependency Parsing(DEP)methods with a robust offensive language classification module.Our architecture enriches the Transformer encoder with syntax-aware embeddings and provides syntax-guided attention mechanisms.The architecture incorporates a structure-aware contrastive loss that reinforces syntactic consistency and deploys auxiliary classification heads for POS tagging,dependency parsing,and multi-class offensive detection.The classifier for offensive words operates at both sentence and token levels and obtains guidance from syntactic features and formal finite automata rules that model offensive language structures-hate speech,profanity,sarcasm,and threats.Using this architecture,we construct a syntactically enriched,socially annotated corpus.Experimental results show improvements in translation quality,with a BLEU score of 33.5,UAS/LAS parsing accuracies of 92.4%and 90%,and a 4.5%Fl-score gain in offensive content detection compared with baseline POS+DEP+Offense models.Also,the proposed model achieved 92.3%in offensive content neutralization,as confirmed by ablation studies.This comprehensive English-Tamil NMT model that unifies syntactic modelling and ethical filtering-laying the groundwork for applications in social media moderation,hate speech mitigation,and policy-compliant multilingual content generation.展开更多
Early and accurate detection of bone cancer and marrow cell abnormalities is critical for timely intervention and improved patient outcomes.This paper proposes a novel hybrid deep learning framework that integrates a ...Early and accurate detection of bone cancer and marrow cell abnormalities is critical for timely intervention and improved patient outcomes.This paper proposes a novel hybrid deep learning framework that integrates a Convolutional Neural Network(CNN)with a Bidirectional Long Short-Term Memory(BiLSTM)architecture,optimized using the Firefly Optimization algorithm(FO).The proposed CNN-BiLSTM-FO model is tailored for structured biomedical data,capturing both local patterns and sequential dependencies in diagnostic features,while the Firefly Algorithm fine-tunes key hyperparameters to maximize predictive performance.The approach is evaluated on two benchmark biomedical datasets:one comprising diagnostic data for bone cancer detection and another for identifying marrow cell abnormalities.Experimental results demonstrate that the proposed method outperforms standard deep learning models,including CNN,LSTM,BiLSTM,and CNN-LSTM hybrids,significantly.The CNNBiLSTM-FO model achieves an accuracy of 98.55%for bone cancer detection and 96.04%for marrow abnormality classification.The paper also presents a detailed complexity analysis of the proposed algorithm and compares its performance across multiple evaluation metrics such as precision,recall,F1-score,and AUC.The results confirm the effectiveness of the firefly-based optimization strategy in improving classification accuracy and model robustness.This work introduces a scalable and accurate diagnostic solution that holds strong potential for integration into intelligent clinical decision-support systems.展开更多
The asymptotic behavior of the nonoscillatory solutions of the difference equations △[r(n)△x(n)]+f(n,x(n),x(r(n,x(n))))=0 is considered. In the case when f is a strongly sublinear (superlinear) function, conditions ...The asymptotic behavior of the nonoscillatory solutions of the difference equations △[r(n)△x(n)]+f(n,x(n),x(r(n,x(n))))=0 is considered. In the case when f is a strongly sublinear (superlinear) function, conditions for oscillations of (1) are also found.展开更多
基金supported by the National Research Foundation of Korea(NRF)grants funded by the Korean government(MSIT)(NRF-2020R1A2C2005790,NRF2023R1A2C1007510,RS-2023-00269830,RS-2024-00438542)。
文摘Primary cilia function as critical sensory organelles that mediate multiple signaling pathways,including the Hedgehog(Hh)pathway,which is essential for organ patterning and morphogenesis.Disruptions in Hh signaling have been implicated in supernumerary tooth formation and molar fusion in mutant mice.Cilk1,a highly conserved serine/threonine-protein kinase localized within primary cilia,plays a critical role in ciliary transport.Loss of Cilk1 results in severe ciliopathy phenotypes,including polydactyly,edema,and cleft palate.However,the role of Cilk1 in tooth development remains unexplored.In this study,we investigated the role of Cilk1 in tooth development.Cilk1 was found to be expressed in both the epithelial and mesenchymal compartments of developing molars.Cilk1 deficiency resulted in altered ciliary dynamics,characterized by reduced frequency and increased length,accompanied by downregulation of Hh target genes,such as Ptch1 and Sostdc1,leading to the formation of diastemal supernumerary teeth.Furthermore,in Cilk1^(-/-);PCS1–MRCS1^(△/△)mice,which exhibit a compounded suppression of Hh signaling,we uncovered a novel phenomenon:diastemal supernumerary teeth can be larger than first molars.Based on these findings,we propose a progressive model linking Hh signaling levels to sequential changes in tooth patterning:initially inducing diastemal supernumerary teeth,then enlarging them,and ultimately leading to molar fusion.This study reveals a previously unrecognized role of Cilk1 in controlling tooth morphology via Hh signaling and highlights how Hh signaling levels shape tooth patterning in a gradient-dependent manner.
文摘For a one-dimensional conservative system with position depending mass, one deduces consistently a constant of motion, a Lagrangian, and a Hamiltonian for the nonrelativistic case. With these functions, one shows the trajectories on the spaces (x,v) and (x,p) for a linear position depending mass. For the relativistic case, the Lagrangian and Hamiltonian cannot be given explicitly in general. However, we study the particular system with constant force and mass linear dependence on the position where the Lagrangian can be found explicitly, but the Hamiltonian remains implicit in the constant of motion.
文摘The panicle size has a strong impact on the interactions between nanoparticles and cells. However, the synthesis process of nanoparticles limits the range of achievable average panicle sizes. When biocompatible hydroxyapatite nanoparticles （HAP） are doped with the luminescent rare earth elemeat Europium （Eu）, the panicle size becomes larger compared to pure HAP. Hence, a panicle size reduction is necessary to achieve similar experimental conditions when stbstituting pure HAP with luminescent HAP ： Eu nanoparticles to investigate particlecell-interactions in cell culture experiments. While the sedimentation process of particles in liquids and gels has been well described in literature, the separation of particles in dispersed colloids has not been studied, yet. In this study, the size depending separation and particle size redaction of a homogeneous dispersed nanoparticle sol by gravity and centrifugation were investigated. As the results showed, shorter time of centrifugation at higher speed can reduce the average particle size compared to the decline of the panicle concentation in the upper sol layer most efficiently. This ceatrifugation method has some similarity to the overspeeding technique which is commonly used to lower the transient time to reach the equilibrium of sedimentation.
基金Supported by the National Natural Science Foundation of China under Grant No 11626047the Foundation for Young Key Teachers of Chengdu University of Technology under Grant No KYGG201414
文摘To describe the energy-dependent characteristics of the reaction-subdiffusion process, we analyze the simple reaction A--→B under subdiffsion with waiting time depending on the preceding jump length, and derive the corresponding master equations in the Fourier Laplace space for the distribution of A and B particles in a continuous time random walk scheme. Moreover, the generalizations of the reaction-diffusion equation for the Gaussian jump length with the probability density function of waiting time being quadratically dependent on the preceding jump length are obtained by applying the derived master equations.
文摘We study the classical dynamics of binary stars when there is an interchange of mass between them. Assuming that one of the stars is more massive than others, the dynamics of the lighter one is analyzed as a function of its time depending mass variation. Within our approximations and models for mass transference, we obtain a general result which establishes that if the lightest star looses mass, its period increases. If the lightest star wins mass, its period decreases.
文摘The relocity and sirain-rate .field which are different from Avilzur's have beenestablished in Caitesian coordinates. Using the integral as a function of the upper limitand integration depending on a parameler, an analylical upper-bound solution todrawing stress through idling rolls has been obtained in this paper.
文摘Forl a 1-D conservative system with a position depending mass within a dissipative medium, its effect on the body is to exert a force depending on the squared of its velocity, a constant of motion, Lagrangian, generalized linear momentum, and Hamiltonian are obtained. We apply these new results to the harmonic oscillator and pendulum under the characteristics mentioned about, obtaining their constant of motion, Lagrangian and Hamiltonian for the case when the body is increasing its mass.
文摘Somalia＇s rebirth relies greatly on the return of its many refugees MOGADISHU is on the mend and on the rise.A booming construction industry is building high-rise blocks that compete for skyline dominance,shops are opening up at a much faster rate than two years earlier and airlines are launching routes to what has hitherto been considered the world＇s most dangerous city. Despite a rise in the number of ambushes,assassinations and suicide bombings in the city in August,a sign that Somali militant group Al-Shabaab has renewed its campaign to bring instability to the nation＇s capital,a sense of optimism still abounds as the country slowly makes its way back into the international arena.The United Kingdom has reopened its embassy after a 22-year closure.
文摘Au/Zn O/n-type Si device is obtained using atomic layer deposition（ALD） for Zn O layer, and some main electrical parameters are investigated, such as surface/interface state（Nss）, barrier height（Φb）, series resistance（Rs）, donor concentration（Nd）, and dielectric characterization depending on frequency or voltage. These parameters are acquired by use of impedance spectroscopy measurements at frequencies ranging from 10 k Hz to 1 MHz and the direct current（DC） bias voltages in a range from-2 V to ＋2 V at room temperature are used. The main electrical parameters and dielectric parameters,such as dielectric constant（ε＂）, dielectric loss（ε＂）, loss tangent（tan δ）, the real and imaginary parts of electric modulus（M and M）, and alternating current（AC） electrical conductivity（σ） are affected by changing voltage and frequency. The characterizations show that some main electrical parameters usually decrease with increasing frequency because charge carriers at surface states have not enough time to fallow an external AC signal at high frequencies, and all dielectric parameters strongly depend on the voltage and frequency especially in the depletion and accumulation regions. Consequently, it can be concluded that interfacial polarization and interface charges can easily follow AC signal at low frequencies.
文摘A series of blue and blue‑green Ir(Ⅲ)complexes has been investigated theoretically to explore their electronic structures,photophysical properties,efficiency roll‑off effect,and thermal activation delayed fluorescence(TADF)properties.All calculations were performed using density functional theory(DFT)and time‑dependent density functional theory(TDDFT).Calculations for electronic structures,frontier molecular orbital characteristics(which determine the efficiency roll‑off effect of the complexes),and photophysical properties were conducted using the Gaussian 09 software package.The calculation of spin‑orbit coupling matrix elements<T|HSOC|S>,which determine the TADF properties of the complexes,was performed using the ORCA software package.The calculation results show that the auxiliary ligand tetraphenylimidodiphosphinate(tpip),a strong electron‑withdrawing group,can mitigate the efficiency roll‑off effect of the complex.Furthermore,TADF is observed in one of the designed complexes,(F_(3)Phppy)_(2)Ir(tpip),where F_(3)Phppy=2‑[4‑(2,4,6‑trifluorophenyl)phenyl]pyridine.
文摘Background:This study aims to investigate the underlying mechanisms between parental marital conflict and adolescent short video dependence by constructing a chain mediation model,focusing on the mediating roles of experiential avoidance and emotional disturbance(anxiety,depression,and stress).Methods:Conducted in January 2025,the research recruited 4125 adolescents from multiple Chinese provinces through convenience sampling;after data cleaning,3957 valid participants(1959 males,1998 females)were included.Using a cross-sectional design,measures included parental marital conflict,experiential avoidance,anxiety,depression,stress,and short video dependence.Results:Pearson correlation analysis revealed significant positive correlations among all variables.Mediation analysis using the SPSS PROCESS macro showed that parental marital conflict directly predicted short video dependence(β=0.269,p<0.001),and also significantly predicted experiential avoidance(β=0.519,p<0.001),anxiety(β=0.072,p<0.001),depression(β=0.067,p<0.001),and stress(β=0.048,p<0.05).Experiential avoidance further predicted anxiety(β=0.521,p<0.001),depression(β=0.489,p<0.001),stress(β=0.408,p<0.001),and short video dependence(β=0.244,p<0.001).While both anxiety(β=0.050,p<0.05)and depression(β=0.116,p<0.001)positively predicted short video dependence,stress did not(β=0.019,p=0.257).Overall,experiential avoidance,anxiety,depression,and stress significantly mediated the relationship between parental marital conflict and short video dependence.Conclusion:These findings confirm that parental marital conflict not only directly influences adolescent short video dependence but also operates through a chain mediation pathway involving experiential avoidance and emotional disturbance,highlighting central psychological mechanisms and providing theoretical support for integrated mental health and behavioral interventions.
基金Project(51978674)supported by the National Natural Science Foundation of China。
文摘Conglomerate rock's complex and heterogeneous microstructure significantly affects its mechanical properties,especially under dynamic loading.However,research on their dynamic behavior and fracture mechanisms is limited.Through uniaxial compression tests and split Hopkinson pressure bar(SHPB)impact tests,the dynamic compressive mechanical properties and fracture mechanisms of conglomerate rock were studied.Nanoindentation and high-resolution X-ray computed tomography were employed to analyze the micro-mechanical behavior and internal structure of the conglomerate rock.Results indicate significant differences in mechanical properties between different gravel particles and cementing materials,with initial fractures primarily distributed at the gravel-cement interfaces.The dynamic mechanical properties of conglomerate rocks exhibit a clear strain rate dependency.Based on the stress−strain curves and failure characteristics,the dynamic compressive mechanical behavior can be categorized into two types using a critical strain rate.The dynamic compressive strength,peak strain,and toughness of conglomerate rock increased with the strain rate,with the strength at 54 s−1 being 2.6 times that at 6 s−1.The dynamic compressive fracture mechanism of conglomerate rock is related to the strain rate and microstructure;at low strain rates,gravel distribution is the key factor,whereas at high strain rates,gravel content becomes critical.
基金Da Nang University of Medical Technology and PharmacyDa Nang C Hospital for the invaluable support they provided in facilitating this research。
文摘Objective:The aging population is growing rapidly,leading to a rise in chronic diseases and placing significant physical,emotional,and financial strain on caregivers.Managing chronic conditions alongside caregiving responsibilities often results in burnout,adding to the burden on caregivers.This issue also affects society and healthcare systems through increased costs and greater demands for support services.Understanding the factors contributing to caregiver burden is crucial for creating effective interventions to address these challenges.The aim of this study is to describe the extent of caregiver burden and identify some factors related to burden among caregivers of chronically ill elderly people.By gaining insight into these relationships,this study seeks to identify strategies to reduce the burden on caregivers.Methods:This study utilized a cross-sectional design to examine caregivers of the elderly with chronic diseases receiving treatment in the public healthcare facility.Data collection involved administering structured questionnaires that gathered information on the demographic characteristics of both the elderly and their caregivers,the level of social support received,the functional status of patients as measured by daily activity indices,and the level of caregiver burden.Description was used to elaborate the characteristics of participants.Mann-Whitney,Kruskal-Wallis,and Spearman's correlation test were applied to explore the relationship between variables.Statistical significance was determined at P value<0.05.Results:Caregivers of the elderly with chronic diseases had a moderate care burden score(22.62±11.24,CI:95%).The patients'level of dependence,relationship with the patients,and time spent as a caregiver were factors related to caregiver burden(P<0.05).Conclusions:Those who care for elderly people with chronic diseases suffered great burden.The finding had found a number of factors that influence the caregivers'weight loss.Healthcare providers should consider these relevant factors when developing intervention plans to reduce caregiver burden.
基金financially supported by the National Natural Science Foundation of China(Nos.22475057 and No.52373262).
文摘Directional three-dimensional carbon-based foams are emerging as highly attractive candidates for promising electromagnetic wave absorbing materials(EWAMs)thanks to their unique architecture,but their construction usually involves complex procedures and extremely depends on unidirectional freezing technique.Herein,we propose a groundbreaking approach that leverages the assemblies of salting-out protein induced by ammonium metatungstate(AM)as the precursor,and then acquire directional three-dimensional carbon-based foams through simple pyrolysis.The electrostatic interaction between AM and protein ensures well dispersion of WC_(1−x)nanoparticles on carbon frameworks.The content of WC_(1−x)nanoparticles can be rationally regulated by AM dosage,and it also affects the electromagnetic(EM)properties of final carbon-based foams.The optimized foam exhibits exceptional EM absorption performance,achieving a remarkable minimum reflection loss of−72.0 dB and an effective absorption bandwidth of 6.3 GHz when EM wave propagates parallel to the directional pores.Such performance benefits from the synergistic effects of macroporous architecture and compositional design.Although there is a directional dependence of EM absorption,radar stealth simulation demonstrates that these foams can still promise considerable reduction in radar cross section with the change of incident angle.Moreover,COMSOL simulation further identifies their good performance in preventing EM interference among different electronic components.
基金supported by Natural Science Foundation of Inner Mongolia Autonomous Region of China (2023MS03027)the National Natural Science Foundation of China (31860185 and 31160141)
文摘Distributions of nuclear magnetic resonance(NMR)relaxation times provide detailed information about the water in wood.This study documents the water dynamics analysis of T_(2)and T_(1)distributions for saturated delignified sapwood(DSW),delignified heartwood(DHW)and lignocellulose(LC)samples at different temperatures.Results indicate that below the freezing point of bulk water,free water freezes,causing its signal to disappear from the distribution.Then,the low temperature distributions of the unfrozen bound water contain more information about its components,with DSW,DHW and LC containing two distinct states of bound water(OH bound water(B-water)and more freely bound water(C-water)).Furthermore,it was observed that within the temperature range of−3°C to−60°C,B-water in DSW,DHW and LC maintained a higher unfrozen water content(UWC)value than C-water,and the T_(1)/T_(2)ratios for B-water were consistently higher than that for C-water,indicating that B-water has a greater antifreeze capacity.T_(2)and T_(1)distributions offer different kinds of information about water components,and all peaks within the distribution have been assigned.
基金supported by Major Scientific and Technological Innovation Project of Shandong Province(No.2020CXGC011204)Qingdao Natural Science Foundation(No.23-2-1-234-zyyd-jch).
文摘The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alone and UV-LED/H_(2)O_(2) system as their complex interactions.Tetracycline(TC)degradation efficiency(kF)correlated closely with its UV molar absorbance(R^(2)=0.831)in UV-LED alone system and with·OH yield(R^(2)=0.999)in UV-LED/H_(2)O_(2) system across studied wavelengths(265,280 and 310 nm).The kF values for intracellular DNA(i-ARGs)also exhibited a high correlation with UV-LED wavelengths in both systems(R^(2)=0.997-0.999).The coexistence of TC and ARB/ARGs resulted in a mutual inhibition of their degradation efficiencies due to competition for photons and·OH,along with the consequent reduction in intracellular ROS within ARB,with their degradation efficiencies exhibiting marked dependence on wavelength in both systems.Notably,the UV-LED/H_(2)O_(2) system at 265 nm effectively achieved the simultaneous removal of TC,ARB and ARGs with minimal energy consumption,and successfully fragmented ARGs.The degradation pathway of TC was analyzed,and the biotoxicity of its degradation intermediates demonstrated the environmental friendliness and safety of UV-LED/H_(2)O_(2) technology.This study elucidated the competitive interactions between antibiotics and ARB/ARGs within UV-LED/H_(2)O_(2) system,providing a promising approach for their simultaneous removal while ensuring energy efficiency.
文摘When performing English-to-Tamil Neural Machine Translation(NMT),end users face several challenges due to Tamil's rich morphology,free word order,and limited annotated corpora.Although available transformer-based models offer strong baselines,they compromise syntactic awareness and the detection and man-agement of offensive content in cluttered,noisy,and informal text.In this paper,we present POSDEP-Offense-Trans,a multi-task NMT framework that combines Part-of-Speech(POS)and Dependency Parsing(DEP)methods with a robust offensive language classification module.Our architecture enriches the Transformer encoder with syntax-aware embeddings and provides syntax-guided attention mechanisms.The architecture incorporates a structure-aware contrastive loss that reinforces syntactic consistency and deploys auxiliary classification heads for POS tagging,dependency parsing,and multi-class offensive detection.The classifier for offensive words operates at both sentence and token levels and obtains guidance from syntactic features and formal finite automata rules that model offensive language structures-hate speech,profanity,sarcasm,and threats.Using this architecture,we construct a syntactically enriched,socially annotated corpus.Experimental results show improvements in translation quality,with a BLEU score of 33.5,UAS/LAS parsing accuracies of 92.4%and 90%,and a 4.5%Fl-score gain in offensive content detection compared with baseline POS+DEP+Offense models.Also,the proposed model achieved 92.3%in offensive content neutralization,as confirmed by ablation studies.This comprehensive English-Tamil NMT model that unifies syntactic modelling and ethical filtering-laying the groundwork for applications in social media moderation,hate speech mitigation,and policy-compliant multilingual content generation.
文摘Early and accurate detection of bone cancer and marrow cell abnormalities is critical for timely intervention and improved patient outcomes.This paper proposes a novel hybrid deep learning framework that integrates a Convolutional Neural Network(CNN)with a Bidirectional Long Short-Term Memory(BiLSTM)architecture,optimized using the Firefly Optimization algorithm(FO).The proposed CNN-BiLSTM-FO model is tailored for structured biomedical data,capturing both local patterns and sequential dependencies in diagnostic features,while the Firefly Algorithm fine-tunes key hyperparameters to maximize predictive performance.The approach is evaluated on two benchmark biomedical datasets:one comprising diagnostic data for bone cancer detection and another for identifying marrow cell abnormalities.Experimental results demonstrate that the proposed method outperforms standard deep learning models,including CNN,LSTM,BiLSTM,and CNN-LSTM hybrids,significantly.The CNNBiLSTM-FO model achieves an accuracy of 98.55%for bone cancer detection and 96.04%for marrow abnormality classification.The paper also presents a detailed complexity analysis of the proposed algorithm and compares its performance across multiple evaluation metrics such as precision,recall,F1-score,and AUC.The results confirm the effectiveness of the firefly-based optimization strategy in improving classification accuracy and model robustness.This work introduces a scalable and accurate diagnostic solution that holds strong potential for integration into intelligent clinical decision-support systems.
基金the National Natural Science Foundation of China (No.69982002) and theNationa1 Key Basic Research Special Found (No.G199802030
文摘The asymptotic behavior of the nonoscillatory solutions of the difference equations △[r(n)△x(n)]+f(n,x(n),x(r(n,x(n))))=0 is considered. In the case when f is a strongly sublinear (superlinear) function, conditions for oscillations of (1) are also found.
