Piroxicam is commonly used as anti-inflammatory and pain relieving drug;however, its side effects include fluid retention, renal damage and heart failure. This study aimed at evaluating the nephroprotective role of di...Piroxicam is commonly used as anti-inflammatory and pain relieving drug;however, its side effects include fluid retention, renal damage and heart failure. This study aimed at evaluating the nephroprotective role of different doses of the tannin-rich extract of Chasmanthera dependens stem (TRECDS) on piroxicam-induced nephrotoxicity in adult male Wistar rats. Thirty-two adult rats were divided into four groups of eight rats per group and treated orally for ten days. Rats in group one received 0.5 ml normal saline (0.9% v/v) and served as normal control group. Rats in group two received 20 mg/kg body weight piroxicam alone. Rats in groups three and four received 20 mg/kg body weight of piroxicam with concomitant administration of 200 and 400 mg/kg body weight of TRECDS. At the expiration of the experiment, rats were sacrificed and the kidney was removed. Renal function was evaluated. The results showed that administration of piroxicam alone caused a significant elevation in the serum concentrations of albumin, creatinine, total protein, urea concentrations and the activity of renal nucleotidase with a reduction in the activity of glucose-6-phosphate dehydrogenase (G6PD) when compared to normal control (p < 0.05). Furthermore, renal tissue from the piroxicam alone treated group revealed a significant decrease in the activities of renal superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase as well as reduced glutathione with concomitant increase in lipid peroxidation and hydrogen peroxide generation. In addition, histological assessment of the renal tissue showed noticeable damage in piroxicam alone treated group. However, concomitant administration of TRECDS showed a dose-dependent reduction in the concentrations and the activity of the kidney markers with significant increase in the activities of G6PD and restores the antioxidant status of the kidney. The results show the nephroprotective potential of TREDS against piroxicam-induced renal damage.展开更多
The plant <i>Chasmanthera dependens </i>(Hochst) have been used to manage many diseases including diabetes mellitus without scientific evaluation of its efficacy and safety. The main objective of the proje...The plant <i>Chasmanthera dependens </i>(Hochst) have been used to manage many diseases including diabetes mellitus without scientific evaluation of its efficacy and safety. The main objective of the project was to determine the antidiabetic activity of <i>Chasmanthera dependens</i> plant in a rat model. Experimental design was used where<b> </b>the stem of the plant was collected, dried, crashed into fine powder, extracted with distilled water at 60<span lang="EN-US">°C and lyophilized using a Freeze Dryer, packaged in air tight container and stored at -20°C ready for use. The extract was orally and intraperitoneally screened in alloxan induced diabetic mice for its hypoglycemic activity at doses of 25, 48.4, 93.5, 180.9 and 350 mg per kg body weight. Diabetes in mice was induced using 186.9 mg/kg of alloxan monohydrate. Negative controls included normal and diabetic rats orally and intraperitoneally administered with physiological saline while positive controls included diabetic rats administered with glibenclamide as oral and insulin as intraperitoneal reference drug. The results revealed hypoglycemic activity in <i>Chasmanthera dependens </i>at the five different doses when given either orally or intraperitoneally. In conclusion, the medicinal plant at the various doses demonstrated significant (<i>ρ</i> ≤ 0.05) hypoglycemic activity. The author’s recommendation is continued use of the plant extracts at low therapeutic doses. Consideration should be made to carry out the same studies using higher animals including man.</span>展开更多
In this paper, we investigate the complete moment convergence for dependent linear processes with random coefficients to form Xt =∑j^∞=∞ Aj∈t-j,where {∈n, n ∈ Z} is a sequence of END stochastically dominated ran...In this paper, we investigate the complete moment convergence for dependent linear processes with random coefficients to form Xt =∑j^∞=∞ Aj∈t-j,where {∈n, n ∈ Z} is a sequence of END stochastically dominated random variables and {An,n ∈ Z} is a sequence of random varibles. As applications, the convergence rate, Marcinkiewicz-Zvgmund strong law and strong law of large numbers for this linear process are established.展开更多
文摘Piroxicam is commonly used as anti-inflammatory and pain relieving drug;however, its side effects include fluid retention, renal damage and heart failure. This study aimed at evaluating the nephroprotective role of different doses of the tannin-rich extract of Chasmanthera dependens stem (TRECDS) on piroxicam-induced nephrotoxicity in adult male Wistar rats. Thirty-two adult rats were divided into four groups of eight rats per group and treated orally for ten days. Rats in group one received 0.5 ml normal saline (0.9% v/v) and served as normal control group. Rats in group two received 20 mg/kg body weight piroxicam alone. Rats in groups three and four received 20 mg/kg body weight of piroxicam with concomitant administration of 200 and 400 mg/kg body weight of TRECDS. At the expiration of the experiment, rats were sacrificed and the kidney was removed. Renal function was evaluated. The results showed that administration of piroxicam alone caused a significant elevation in the serum concentrations of albumin, creatinine, total protein, urea concentrations and the activity of renal nucleotidase with a reduction in the activity of glucose-6-phosphate dehydrogenase (G6PD) when compared to normal control (p < 0.05). Furthermore, renal tissue from the piroxicam alone treated group revealed a significant decrease in the activities of renal superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase as well as reduced glutathione with concomitant increase in lipid peroxidation and hydrogen peroxide generation. In addition, histological assessment of the renal tissue showed noticeable damage in piroxicam alone treated group. However, concomitant administration of TRECDS showed a dose-dependent reduction in the concentrations and the activity of the kidney markers with significant increase in the activities of G6PD and restores the antioxidant status of the kidney. The results show the nephroprotective potential of TREDS against piroxicam-induced renal damage.
文摘The plant <i>Chasmanthera dependens </i>(Hochst) have been used to manage many diseases including diabetes mellitus without scientific evaluation of its efficacy and safety. The main objective of the project was to determine the antidiabetic activity of <i>Chasmanthera dependens</i> plant in a rat model. Experimental design was used where<b> </b>the stem of the plant was collected, dried, crashed into fine powder, extracted with distilled water at 60<span lang="EN-US">°C and lyophilized using a Freeze Dryer, packaged in air tight container and stored at -20°C ready for use. The extract was orally and intraperitoneally screened in alloxan induced diabetic mice for its hypoglycemic activity at doses of 25, 48.4, 93.5, 180.9 and 350 mg per kg body weight. Diabetes in mice was induced using 186.9 mg/kg of alloxan monohydrate. Negative controls included normal and diabetic rats orally and intraperitoneally administered with physiological saline while positive controls included diabetic rats administered with glibenclamide as oral and insulin as intraperitoneal reference drug. The results revealed hypoglycemic activity in <i>Chasmanthera dependens </i>at the five different doses when given either orally or intraperitoneally. In conclusion, the medicinal plant at the various doses demonstrated significant (<i>ρ</i> ≤ 0.05) hypoglycemic activity. The author’s recommendation is continued use of the plant extracts at low therapeutic doses. Consideration should be made to carry out the same studies using higher animals including man.</span>
文摘In this paper, we investigate the complete moment convergence for dependent linear processes with random coefficients to form Xt =∑j^∞=∞ Aj∈t-j,where {∈n, n ∈ Z} is a sequence of END stochastically dominated random variables and {An,n ∈ Z} is a sequence of random varibles. As applications, the convergence rate, Marcinkiewicz-Zvgmund strong law and strong law of large numbers for this linear process are established.
