Obstructive jaundice occurs in patients suffering from cholelithiasis and from neoplasms affecting the pancreas and the common bile duct.The absorption,distribution and elimination of drugs are impaired during this pa...Obstructive jaundice occurs in patients suffering from cholelithiasis and from neoplasms affecting the pancreas and the common bile duct.The absorption,distribution and elimination of drugs are impaired during this pathology.Prolonged cholestasis may alter both liver and kidney function.Lactam antibiotics,diuretics,non-steroidal anti-inflammatory drugs,several antiviral drugs as well as endogenous compounds are classified as organic anions.The hepatic and renal organic anion transport pathways play a key role in the pharmacokinetics of these compounds.It has been demonstrated that acute extrahepatic cholestasis is associated with increased renal elimination of organic anions.The present work describes the molecular mechanisms involved in the regulation of the expression and function of the renal and hepatic organic anion transporters in extrahepatic cholestasis,such as multidrug resistanceassociated protein 2,organic anion transporting polypeptide 1,organic anion transporter 3,bilitranslocase,bromosulfophthalein/bilirubin binding protein,organic anion transporter 1 and sodium dependent bile salt transporter.The modulation in the expression of renal organic anion transporters constitutes a compensatory mechanism to overcome the hepatic dysfunction in the elimination of organic anions.展开更多
Dependability analysis is an important step in designing and analyzing safety computer systems and protection systems.Introducing multi-processor and virtual machine increases the system faults' complexity,diversi...Dependability analysis is an important step in designing and analyzing safety computer systems and protection systems.Introducing multi-processor and virtual machine increases the system faults' complexity,diversity and dynamic,in particular for software-induced failures,with an impact on the overall dependability.Moreover,it is very different for safety system to operate successfully at any active phase,since there is a huge difference in failure rate between hardware-induced and softwareinduced failures.To handle these difficulties and achieve accurate dependability evaluation,consistently reflecting the construct it measures,a new formalism derived from dynamic fault graphs(DFG) is developed in this paper.DFG exploits the concept of system event as fault state sequences to represent dynamic behaviors,which allows us to execute probabilistic measures at each timestamp when change occurs.The approach automatically combines the reliability analysis with the system dynamics.In this paper,we describe how to use the proposed methodology drives to the overall system dependability analysis through the phases of modeling,structural discovery and probability analysis,which is also discussed using an example of a virtual computing system.展开更多
基金Supported by Grants from FONCYT(PICT 2007,No.00966, PICT 2010,No.2127)CONICET(PIP 2009-2011,No.1665, PIP2012-2015,No.00014)UNR PID(2008-2011/2012-2015)
文摘Obstructive jaundice occurs in patients suffering from cholelithiasis and from neoplasms affecting the pancreas and the common bile duct.The absorption,distribution and elimination of drugs are impaired during this pathology.Prolonged cholestasis may alter both liver and kidney function.Lactam antibiotics,diuretics,non-steroidal anti-inflammatory drugs,several antiviral drugs as well as endogenous compounds are classified as organic anions.The hepatic and renal organic anion transport pathways play a key role in the pharmacokinetics of these compounds.It has been demonstrated that acute extrahepatic cholestasis is associated with increased renal elimination of organic anions.The present work describes the molecular mechanisms involved in the regulation of the expression and function of the renal and hepatic organic anion transporters in extrahepatic cholestasis,such as multidrug resistanceassociated protein 2,organic anion transporting polypeptide 1,organic anion transporter 3,bilitranslocase,bromosulfophthalein/bilirubin binding protein,organic anion transporter 1 and sodium dependent bile salt transporter.The modulation in the expression of renal organic anion transporters constitutes a compensatory mechanism to overcome the hepatic dysfunction in the elimination of organic anions.
基金This work was supported in part by National Natural Science Foundation of China under grant No.61272411 and National 973 Basic Research Program of China under grant No.2014CB340600
文摘Dependability analysis is an important step in designing and analyzing safety computer systems and protection systems.Introducing multi-processor and virtual machine increases the system faults' complexity,diversity and dynamic,in particular for software-induced failures,with an impact on the overall dependability.Moreover,it is very different for safety system to operate successfully at any active phase,since there is a huge difference in failure rate between hardware-induced and softwareinduced failures.To handle these difficulties and achieve accurate dependability evaluation,consistently reflecting the construct it measures,a new formalism derived from dynamic fault graphs(DFG) is developed in this paper.DFG exploits the concept of system event as fault state sequences to represent dynamic behaviors,which allows us to execute probabilistic measures at each timestamp when change occurs.The approach automatically combines the reliability analysis with the system dynamics.In this paper,we describe how to use the proposed methodology drives to the overall system dependability analysis through the phases of modeling,structural discovery and probability analysis,which is also discussed using an example of a virtual computing system.
