Most of my classmates like reading books.Students like reading Harry Potter best among them.About 99 percent of the students have read it.They all think it’s very fantastic.The stories make the students excited.The s...Most of my classmates like reading books.Students like reading Harry Potter best among them.About 99 percent of the students have read it.They all think it’s very fantastic.The stories make the students excited.The students also like The Wonderful Adventures of Nils very much.They think it’s very interesting and meaningful.展开更多
In the process of construction and service,high-grade line pipes will get defective,e.g.dents,which will change its stress and strain distribution characteristics and impact its service reliability.In this paper,a X80...In the process of construction and service,high-grade line pipes will get defective,e.g.dents,which will change its stress and strain distribution characteristics and impact its service reliability.In this paper,a X80 line pipe was taken as the research object.The distribution characteristics of the strain field in the X80 line pipe with plain dents with the change of dent depth under external load were analyzed using the finite element analysis software ABAQUS.Then,the strain distribution and microstructure characteristics in the dent zone were explored by conducting prefabrication test on physical dent.Finally,combined with the finite element simulation results,the strain distribution laws of the X80 line pipe with plain dent were discussed.And the following research results were obtained.First,under the same internal pressure,the strain distribution characteristics in the dent zone at different dent depths are similar,i.e.,the strain increases with the increase of the distance from the center of the dent,and decreases rapidly with the increase of the distance after the peak strain.Second,the strain increases with the increase of dent depth,and under the same internal pressure and dent depth,the axial strain is larger than the radial strain at the same location.Third,the greater the dent depth,the stronger the superposition effect of internal pressure and depth on the strain.Fourth,strain hardening occurs on the materials in the initial stage of the dent deformation.With the aggravation of deformation and the extension of dent radius,the strain response ability of materials increases,the grains at the bottom and side walls of the dent zone are elongated along the direction of maximum deformation,the lattice is distorted and strain hardening occurs.As a result,the dislocation density in this zone increases and the interaction occurs between dislocations,as a result,the strength of line steel is enhanced.In conclusion,the research results do well in predicting the stressestrain evolution laws in the process of dent,and provide a theoretical foundation and an experimental basis for studying the influence of mechanical damage on the service safety of pipelines.展开更多
Mohawks,neon colored hair,studded belts and leather jackets have become the stereotypical emblem of punk rock-an aggressive image that has frightened parents for decades on end.The Descendents,however,are pretty much ...Mohawks,neon colored hair,studded belts and leather jackets have become the stereotypical emblem of punk rock-an aggressive image that has frightened parents for decades on end.The Descendents,however,are pretty much the antithesis of the Manic Panic-clad kids coloring the scene.展开更多
The first annual meeting of presidents of China’s localfriendship associations with foreign countries was held in Beijing from January 7 to 8,2004. Presidents or vice presidents, secre-
Shaoxing Shuifu Reeds is professional on producing all kinds of Air Jet Reeds and Flat Reeds,which has an annual output of 90,000 meters air-jet reeds,300,000,000 pcs of profile dents and 60,000 meters of Flat Reeds,W...Shaoxing Shuifu Reeds is professional on producing all kinds of Air Jet Reeds and Flat Reeds,which has an annual output of 90,000 meters air-jet reeds,300,000,000 pcs of profile dents and 60,000 meters of Flat Reeds,Which has been honored with China Air Jet Profile Reeds Research Center by China Textile Machinery Association in 2015.In order to reach the demands of high quality fabric and industrial textile products,the yarn is developing to high count,multicolor,various fibers,and the fabric is developing to high count,high density,environment protection.So we have researched out high density,multicolor,multinozzle,double energy saving type profile reeds to let you choose.展开更多
Dent disease is a rare X-linked recessively inherited renal tubulopathy,caused by variants in the CLCN5(Dent disease type 1,DD1)and OCRL(Dent disease type 2,DD2)genes,and characterized by low molecular weight proteinu...Dent disease is a rare X-linked recessively inherited renal tubulopathy,caused by variants in the CLCN5(Dent disease type 1,DD1)and OCRL(Dent disease type 2,DD2)genes,and characterized by low molecular weight proteinuria,hypercalciuria,microscopic hematuria,or nephrocalcinosis.In the current study,we collected and analyzed clinical data and genetic testing results of 21 children diagnosed with Dent disease,who were hospitalized at the Department of Nephrology,Children's Hospital of Nanjing Medical University between January 2014 and August 2023,aiming to assist in the early diagnosis and treatment of these patients.Among the 21 patients,16(76.19%)had CLCN5 variants,and five(23.81%)had OCRL variants,and four of the variants were novel.All patients presented with low molecular weight proteinuria,14(66.67%)of whom had nephroticrange proteinuria.Eight patients underwent renal biopsies because of diagnostic uncertainty.We transfected the novel CLCN5 missense variant(p.G222R)and OCRL missense variant(p.I371T)plasmids into both HEK293 and HK-2 cells and found a significantly lower expression of the OCRL1 protein in the transfected cells than in the wild-type cells(P<0.05).Moreover,we observed an extremely skewed X-chromosome inactivation pattern in a female patient carrying the same novel CLCN5 variant,as assessed by the human androgen receptor gene assay.These findings provide insight into the clinical characteristics of Dent disease in Chinese patients and may shed light on its pathogenesis.展开更多
Drop-weight impact tests were conducted on 2024-T3 aluminum plates with five types of impactors, and then the effects of the dent on the residual ultimate strength of the 2024-T3 specimens were investigated through ax...Drop-weight impact tests were conducted on 2024-T3 aluminum plates with five types of impactors, and then the effects of the dent on the residual ultimate strength of the 2024-T3 specimens were investigated through axial compression tests. Results indicate that with increase in dent depth, the five types of dents affect the ultimate strength of the plate in different trends. Nevertheless, other than the plate global deflection caused by impacting, the dent itself has unremarkable effect on the ultimate strength. The mathematical expressions are derived regarding the relationship between impact energy factor and the dent depth factor as well as the compressive ultimate strength reduction rate and the dent depth factor.展开更多
文摘Most of my classmates like reading books.Students like reading Harry Potter best among them.About 99 percent of the students have read it.They all think it’s very fantastic.The stories make the students excited.The students also like The Wonderful Adventures of Nils very much.They think it’s very interesting and meaningful.
基金supported by the National Key Research&Development Plan,“Damage Effect and Accident Investigation Technologies of the Burning Explosion of Dangerous Chemical Storage Facilities”(Grant No.2016YFC0801204).
文摘In the process of construction and service,high-grade line pipes will get defective,e.g.dents,which will change its stress and strain distribution characteristics and impact its service reliability.In this paper,a X80 line pipe was taken as the research object.The distribution characteristics of the strain field in the X80 line pipe with plain dents with the change of dent depth under external load were analyzed using the finite element analysis software ABAQUS.Then,the strain distribution and microstructure characteristics in the dent zone were explored by conducting prefabrication test on physical dent.Finally,combined with the finite element simulation results,the strain distribution laws of the X80 line pipe with plain dent were discussed.And the following research results were obtained.First,under the same internal pressure,the strain distribution characteristics in the dent zone at different dent depths are similar,i.e.,the strain increases with the increase of the distance from the center of the dent,and decreases rapidly with the increase of the distance after the peak strain.Second,the strain increases with the increase of dent depth,and under the same internal pressure and dent depth,the axial strain is larger than the radial strain at the same location.Third,the greater the dent depth,the stronger the superposition effect of internal pressure and depth on the strain.Fourth,strain hardening occurs on the materials in the initial stage of the dent deformation.With the aggravation of deformation and the extension of dent radius,the strain response ability of materials increases,the grains at the bottom and side walls of the dent zone are elongated along the direction of maximum deformation,the lattice is distorted and strain hardening occurs.As a result,the dislocation density in this zone increases and the interaction occurs between dislocations,as a result,the strength of line steel is enhanced.In conclusion,the research results do well in predicting the stressestrain evolution laws in the process of dent,and provide a theoretical foundation and an experimental basis for studying the influence of mechanical damage on the service safety of pipelines.
文摘Mohawks,neon colored hair,studded belts and leather jackets have become the stereotypical emblem of punk rock-an aggressive image that has frightened parents for decades on end.The Descendents,however,are pretty much the antithesis of the Manic Panic-clad kids coloring the scene.
文摘The first annual meeting of presidents of China’s localfriendship associations with foreign countries was held in Beijing from January 7 to 8,2004. Presidents or vice presidents, secre-
文摘Shaoxing Shuifu Reeds is professional on producing all kinds of Air Jet Reeds and Flat Reeds,which has an annual output of 90,000 meters air-jet reeds,300,000,000 pcs of profile dents and 60,000 meters of Flat Reeds,Which has been honored with China Air Jet Profile Reeds Research Center by China Textile Machinery Association in 2015.In order to reach the demands of high quality fabric and industrial textile products,the yarn is developing to high count,multicolor,various fibers,and the fabric is developing to high count,high density,environment protection.So we have researched out high density,multicolor,multinozzle,double energy saving type profile reeds to let you choose.
基金supported by the National Natural Science Foundation of China(Grant No.82200744)the Nanjing Science and Technology Development Funding(Grant No.YKK22159).
文摘Dent disease is a rare X-linked recessively inherited renal tubulopathy,caused by variants in the CLCN5(Dent disease type 1,DD1)and OCRL(Dent disease type 2,DD2)genes,and characterized by low molecular weight proteinuria,hypercalciuria,microscopic hematuria,or nephrocalcinosis.In the current study,we collected and analyzed clinical data and genetic testing results of 21 children diagnosed with Dent disease,who were hospitalized at the Department of Nephrology,Children's Hospital of Nanjing Medical University between January 2014 and August 2023,aiming to assist in the early diagnosis and treatment of these patients.Among the 21 patients,16(76.19%)had CLCN5 variants,and five(23.81%)had OCRL variants,and four of the variants were novel.All patients presented with low molecular weight proteinuria,14(66.67%)of whom had nephroticrange proteinuria.Eight patients underwent renal biopsies because of diagnostic uncertainty.We transfected the novel CLCN5 missense variant(p.G222R)and OCRL missense variant(p.I371T)plasmids into both HEK293 and HK-2 cells and found a significantly lower expression of the OCRL1 protein in the transfected cells than in the wild-type cells(P<0.05).Moreover,we observed an extremely skewed X-chromosome inactivation pattern in a female patient carrying the same novel CLCN5 variant,as assessed by the human androgen receptor gene assay.These findings provide insight into the clinical characteristics of Dent disease in Chinese patients and may shed light on its pathogenesis.
基金Projects(13R21421700,13R21421800)sponsored by Shanghai Postdoctoral Scientific Program,China
文摘Drop-weight impact tests were conducted on 2024-T3 aluminum plates with five types of impactors, and then the effects of the dent on the residual ultimate strength of the 2024-T3 specimens were investigated through axial compression tests. Results indicate that with increase in dent depth, the five types of dents affect the ultimate strength of the plate in different trends. Nevertheless, other than the plate global deflection caused by impacting, the dent itself has unremarkable effect on the ultimate strength. The mathematical expressions are derived regarding the relationship between impact energy factor and the dent depth factor as well as the compressive ultimate strength reduction rate and the dent depth factor.
