This paper focuses on some key problems in web community discovery and link analysis.Based on the topic-oriented technology,the characteristics of a bipartite graph are studied.An Х bipartite core set is introduced t...This paper focuses on some key problems in web community discovery and link analysis.Based on the topic-oriented technology,the characteristics of a bipartite graph are studied.An Х bipartite core set is introduced to more clearly define extracting ways.By scanning the topic subgraph to construct Х bipartite graph and then prune the graph with i and j ,an Х bipartite core set,which is also the minimum element of a community,can be found.Finally,a hierarchical clustering algorithm is applied to many Х bipartite core sets and the dendrogram of the community inner construction is obtained.The correctness of the constructing and pruning method is proved and the algorithm is designed.The typical datasets in the experiment are prepared according to the way in HITS（hyperlink-induced topic search）.Ten topics and four search engines are chosen and the returned results are integrated.The modularity,which is a measure of the strength of the community structure in the social network,is used to validate the efficiency of the proposed method.The experimental results show that the proposed algorithm is effective and efficient.展开更多
The molecular mechanisms by which dense core vesicles(DCVs) translocate,tether,dock and prime are poorly understood.In this study,Caenorhabditis elegans was used as a model organism to study the function of Rab protei...The molecular mechanisms by which dense core vesicles(DCVs) translocate,tether,dock and prime are poorly understood.In this study,Caenorhabditis elegans was used as a model organism to study the function of Rab proteins and their effectors in DCV exocytosis.RAB-27/AEX-6,but not RAB-3,was found to be required for peptide release from neurons.By analyzing the movement of DCVs approaching the plasma membrane using total internal reflection fluorescence microscopy,we demonstrated that RAB-27/AEX-6 is involved in the tethering of DCVs and that its effector rabphilin/RBF-1 is required for the initial tethering and subsequent stabilization by docking.展开更多
基金The National Natural Science Foundation of China(No.60773216)the National High Technology Research and Development Program of China(863Program)(No.2006AA010109)+1 种基金the Natural Science Foundation of Renmin University of China(No.06XNB052)Free Exploration Project(985 Project of Renmin University of China)(No.21361231)
文摘This paper focuses on some key problems in web community discovery and link analysis.Based on the topic-oriented technology,the characteristics of a bipartite graph are studied.An Х bipartite core set is introduced to more clearly define extracting ways.By scanning the topic subgraph to construct Х bipartite graph and then prune the graph with i and j ,an Х bipartite core set,which is also the minimum element of a community,can be found.Finally,a hierarchical clustering algorithm is applied to many Х bipartite core sets and the dendrogram of the community inner construction is obtained.The correctness of the constructing and pruning method is proved and the algorithm is designed.The typical datasets in the experiment are prepared according to the way in HITS（hyperlink-induced topic search）.Ten topics and four search engines are chosen and the returned results are integrated.The modularity,which is a measure of the strength of the community structure in the social network,is used to validate the efficiency of the proposed method.The experimental results show that the proposed algorithm is effective and efficient.
基金supported by the National Basic Research Program of China(Grant No. 2010CB833701)the National Natural Science Foundation of China(Grant Nos. 30870564 and 90913022)the CAS Project(Grant No.KSCX2-SW-224)
文摘The molecular mechanisms by which dense core vesicles(DCVs) translocate,tether,dock and prime are poorly understood.In this study,Caenorhabditis elegans was used as a model organism to study the function of Rab proteins and their effectors in DCV exocytosis.RAB-27/AEX-6,but not RAB-3,was found to be required for peptide release from neurons.By analyzing the movement of DCVs approaching the plasma membrane using total internal reflection fluorescence microscopy,we demonstrated that RAB-27/AEX-6 is involved in the tethering of DCVs and that its effector rabphilin/RBF-1 is required for the initial tethering and subsequent stabilization by docking.
