The development of polymeric materials that exhibit blue thermally activated delayed fluorescence(TADF)is of great interest for optoelectronic applications.However,achieving TADF in polymers often requires an elaborat...The development of polymeric materials that exhibit blue thermally activated delayed fluorescence(TADF)is of great interest for optoelectronic applications.However,achieving TADF in polymers often requires an elaborate monomer design.The high-energy local triplet state(^(3)LE)of carbazole complicates its application despite the molecular orbital arrangement being suitable for blue emission.Here,we present an approach to polymer design that makes it possible to solve this problem.We demonstrate the in situ formation of a TADF donor-acceptor system during Suzuki polycondensation,creating an extended carbazole-based donor matrix coupled with a triazine acceptor.The resulting polymer exhibited efficient TADF with a low energy gap(ΔE_(ST))value if a phenyl N-substituent,enabling essential electron delocalization,was present in the carbazole moiety.This work establishes a versatile platform for developing carbazole-based TADF polymers,overcoming the fundamental limitations that hinder their widespread application.展开更多
Delayed wound healing following radical gastrectomy remains an important yet underappreciated complication that prolongs hospitalization,increases costs,and undermines patient recovery.In An et al’s recent study,the ...Delayed wound healing following radical gastrectomy remains an important yet underappreciated complication that prolongs hospitalization,increases costs,and undermines patient recovery.In An et al’s recent study,the authors present a machine learning-based risk prediction approach using routinely available clinical and laboratory parameters.Among the evaluated algorithms,a decision tree model demonstrated excellent discrimination,achieving an area under the curve of 0.951 in the validation set and notably identifying all true cases of delayed wound healing at the Youden index threshold.The inclusion of variables such as drainage duration,preoperative white blood cell and neutrophil counts,alongside age and sex,highlights the pragmatic appeal of the model for early postoperative monitoring.Nevertheless,several aspects warrant critical reflection,including the reliance on a postoperative variable(drainage duration),internal validation only,and certain reporting inconsistencies.This letter underscores both the promise and the limitations of adopting interpretable machine learning models in perioperative care.We advocate for transparent reporting,external validation,and careful consideration of clinically actionable timepoints before integration into practice.Ultimately,this work represents a valuable step toward precision risk stratification in gastric cancer surgery,and sets the stage for multicenter,prospective evaluations.展开更多
Time-delayed blasting is widely utilized in engineering to mitigate induced vibration hazards and enhance fragmentation.The underlying vibration reduction principle is the decrease of the charge weight per delay,while...Time-delayed blasting is widely utilized in engineering to mitigate induced vibration hazards and enhance fragmentation.The underlying vibration reduction principle is the decrease of the charge weight per delay,while the potential for further vibration reduction remains debated,largely due to unclear underlying mechanisms.In light of the popularization of electronic detonators and the representativeness of double-hole configurationsfor multiple blastholes,it is essential to investigate the vibration characteristics induced by time-delayed double blastholes.Therefore,a series of doubleborehole experimental blasts was conducted in an underground roadway to clarify the variation in vibration from single-hole to dual-hole conditions.Based on the experimental data and inherent limitations,an exact full-fieldtheoretical model was further employed to systematically analyze the effects of delay time,charge length,and borehole inclination angle on vibrations induced by various doublehole configurations.The experimental data and theoretical analysis reveal that the general scaled distance effectively predicts vibrations in delayed blasting but does not reflectvibration reduction.Increasing delay time causes fluctuatingPPVs,which stabilize slightly above single-hole PPVs as delay times exceed a certain value.The delayed blasting primarily reduces near-fieldfrequencies.Longer charge lengths in double boreholes increase PPV levels and attenuation rates within a certain length,and the vibration behavior of combined long and short charge lengths is governed by the long blasthole.Larger blasthole inclination angles enhance vibration amplitude and reduce PPV attenuation rates.Optimizing inclination angles is more critical than adjusting delay times,and parallel boreholes offer the best vibration control.展开更多
A series of blue and blue‑green Ir(Ⅲ)complexes has been investigated theoretically to explore their electronic structures,photophysical properties,efficiency roll‑off effect,and thermal activation delayed fluorescenc...A series of blue and blue‑green Ir(Ⅲ)complexes has been investigated theoretically to explore their electronic structures,photophysical properties,efficiency roll‑off effect,and thermal activation delayed fluorescence(TADF)properties.All calculations were performed using density functional theory(DFT)and time‑dependent density functional theory(TDDFT).Calculations for electronic structures,frontier molecular orbital characteristics(which determine the efficiency roll‑off effect of the complexes),and photophysical properties were conducted using the Gaussian 09 software package.The calculation of spin‑orbit coupling matrix elements<T|HSOC|S>,which determine the TADF properties of the complexes,was performed using the ORCA software package.The calculation results show that the auxiliary ligand tetraphenylimidodiphosphinate(tpip),a strong electron‑withdrawing group,can mitigate the efficiency roll‑off effect of the complex.Furthermore,TADF is observed in one of the designed complexes,(F_(3)Phppy)_(2)Ir(tpip),where F_(3)Phppy=2‑[4‑(2,4,6‑trifluorophenyl)phenyl]pyridine.展开更多
Delayed neurocognitive recovery following anesthesia and surgery is a common complication in older adult patients.Synapses are fundamental to cognitive function.The activity of synapses heavily depends on the energy s...Delayed neurocognitive recovery following anesthesia and surgery is a common complication in older adult patients.Synapses are fundamental to cognitive function.The activity of synapses heavily depends on the energy supplied by synaptic mitochondria,which are significantly influenced by oxidative stress.Sirtuin 3 is a histone deacetylase located in the mitochondrial matrix that plays a pivotal role in regulating mitochondrial function.However,it remains unclear whether and how sirtuin 3 is involved in the development of delayed cognitive recovery.Therefore,in this study,we investigated the potential role of sirtuin 3 in synapses during delayed neurocognitive recovery.Our results showed that anesthesia and surgery induced cognitive impairment in mice and reduced sirtuin 3 protein expression.Overexpression of sirtuin 3 inhibited opening of the mitochondrial permeability transition pore by reducing acetylation of K166 on cyclophilin D and also rescued cognitive impairment.Aged mice carrying the cyclophilin D-K166R mutation exhibited significantly reduced cognitive impairment.Similarly,administering the mitochondrial permeability transition pore blocker,cyclosporine A,effectively alleviated the decline in synaptic mitochondrial function and cognitive impairment caused by anesthesia and surgery in aged mice.These results indicate that the sirtuin 3/cyclophilin D-K166/mPTP signaling pathway in hippocampal synaptic mitochondria is involved in delayed neurocognitive recovery of aged mice,suggesting this pathway could serve as a potential target for treatment.展开更多
Time delay and Doppler shift between the echo signal and the reference signal are two most commonly used measurements in target localization for the passive radar. Doppler rate, which can be obtained from the extended...Time delay and Doppler shift between the echo signal and the reference signal are two most commonly used measurements in target localization for the passive radar. Doppler rate, which can be obtained from the extended cross ambiguity function, offers an opportunity to further enhance the localization accuracy. This paper considers using the measurement Doppler rate in addition to measurements of time delay and Doppler shift to locate a moving target. A closed-form solution is developed to accurately and efficiently estimate the target position and velocity.The proposed solution establishes a pseudolinear set of equations by introducing some additional variables, imposes weighted least squares formulation to yield a rough estimate, and utilizes the function relation among the target location parameters and additional variables to improve the estimation accuracy. Theoretical covariance and Cramer-Rao lower bound(CRLB) are derived and compared, analytically indicating that the proposed solution attains the CRLB. Numerical simulations corroborate this analysis and demonstrate that the proposed solution outperforms existing methods.展开更多
The proposed Doppler measurement technique shows that the Doppler measurements can be accomplished by a single pulse with multiple frequency components through optical fibre delay lines.Range and velocity ambiguity ca...The proposed Doppler measurement technique shows that the Doppler measurements can be accomplished by a single pulse with multiple frequency components through optical fibre delay lines.Range and velocity ambiguity can be removed,and the velocity resolution can be improved dramatically by using long optical fibre delay lines.Furthermore,the velocity resolution can be modified by adjusting the length of optical fibre delay lines.In addition,the proposed radar can achieve high range resolution by using a single wideband pulse.As a result,the new approach can improve radar performance significantly.展开更多
As an advanced device for observing atmospheric winds,the spaceborne Doppler Asymmetric Spatial Heterodyne(DASH)interferometer also encounters challenges associated with phase distortion,par-ticularly in limb sounding...As an advanced device for observing atmospheric winds,the spaceborne Doppler Asymmetric Spatial Heterodyne(DASH)interferometer also encounters challenges associated with phase distortion,par-ticularly in limb sounding scenarios.This paper discusses interferogram modeling and phase distortion cor-rection techniques for spaceborne DASH interferometers.The modeling of phase distortion interferograms with and without Doppler shift for limb observation was conducted,and the effectiveness of the analytical expression was verified through numerical simulation.The simulation results indicate that errors propagate layer by layer while using the onion-peeling inversion algorithm to handle phase-distorted interferograms.In contrast,the phase distortion correction algorithm can achieve effective correction.This phase correction method can be successfully applied to correct phase distortions in the interferograms of the spaceborne DASH interferometer,providing a feasible solution to enhance its measurement accuracy.展开更多
Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay di...Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay differential equations(DDEs)and delay integrodifferential equations(DIDEs)with constant delays,primarily due to their low regularity at delayinduced breaking points.In this paper,a DNN method that combines multi-task learning(MTL)which is proposed to solve both the forward and inverse problems of DIDEs.The core idea of this approach is to divide the original equation into multiple tasks based on the delay,using auxiliary outputs to represent the integral terms,followed by the use of MTL to seamlessly incorporate the properties at the breaking points into the loss function.Furthermore,given the increased training dificulty associated with multiple tasks and outputs,we employ a sequential training scheme to reduce training complexity and provide reference solutions for subsequent tasks.This approach significantly enhances the approximation accuracy of solving DIDEs with DNNs,as demonstrated by comparisons with traditional DNN methods.We validate the effectiveness of this method through several numerical experiments,test various parameter sharing structures in MTL and compare the testing results of these structures.Finally,this method is implemented to solve the inverse problem of nonlinear DIDE and the results show that the unknown parameters of DIDE can be discovered with sparse or noisy data.展开更多
Wireless communication-enabled Cooperative Adaptive Cruise Control(CACC)is expected to improve the safety and traffic capacity of vehicle platoons.Existing CACC considers a conventional communication delay with fixed ...Wireless communication-enabled Cooperative Adaptive Cruise Control(CACC)is expected to improve the safety and traffic capacity of vehicle platoons.Existing CACC considers a conventional communication delay with fixed Vehicular Communication Network(VCN)topologies.However,when the network is under attack,the communication delay may be much higher,and the stability of the system may not be guaranteed.This paper proposes a novel communication Delay Aware CACC with Dynamic Network Topologies(DADNT).The main idea is that for various communication delays,in order to maximize the traffic capacity while guaranteeing stability and minimizing the following error,the CACC should dynamically adjust the VCN network topology to achieve the minimum inter-vehicle spacing.To this end,a multi-objective optimization problem is formulated,and a 3-step Divide-And-Conquer sub-optimal solution(3DAC)is proposed.Simulation results show that with 3DAC,the proposed DADNT with CACC can reduce the inter-vehicle spacing by 5%,10%,and 14%,respectively,compared with the traditional CACC with fixed one-vehicle,two-vehicle,and three-vehicle look-ahead network topologies,thereby improving the traffic efficiency.展开更多
The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled p...The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled phased array antenna system is a necessary trend for the future development of the phased array,and it is also a major focus and difficulty in the current research of integrated microwave photonics.This paper firstly introduces the basic principle and development history of optical true time delay phased array antenna system based on microwave photonics,and briefly introduces the main implementation methods and integration platform of optical true time delay.Then,the application and development prospect of optical true time delay technology in beam control of phased array antenna system are mainly presented.Finally,according to the current research progress,the possible research directions of integrated optically controlled phased array antenna systems in the future are proposed.展开更多
To address the issue of low measurement accuracy caused by noise interference in the acquisition of low fluid flow rate signals with ultrasonic Doppler flow meters,a novel signal processing algorithm that combines ens...To address the issue of low measurement accuracy caused by noise interference in the acquisition of low fluid flow rate signals with ultrasonic Doppler flow meters,a novel signal processing algorithm that combines ensemble empirical mode decomposition(EEMD)and cross-correlation algorithm was proposed.Firstly,a fast Fourier transform(FFT)spectrum analysis was utilized to ascertain the frequency range of the signal.Secondly,data acquisition was conducted at an appropriate sampling frequency,and the acquired Doppler flow rate signal was then decomposed into a series of intrinsic mode functions(IMFs)by EEMD.Subsequently,these decomposed IMFs were recombined based on their energy entropy,and then the noise of the recombined Doppler flow rate signal was removed by cross-correlation filtering.Finally,an ideal ultrasonic Doppler flow rate signal was extracted.Simulation and experimental verification show that the proposed Doppler flow signal processing method can effectively enhance the signal-to-noise ratio(SNR)and extend the lower limit of measurement of the ultrasonic Doppler flow meter.展开更多
In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave so...In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave solutions for this model under the influence of advection term and distributed delay.The obtained results indicate that weak kernel and strong kernel can both deduce the existence of periodic traveling wave solutions.Finally,we apply the main results in this paper to Logistic model and Nicholson’s blowflies model.展开更多
Time-delay and Doppler shift estimation is a basic task for pulse-Doppler radar processing. For low-rate sampling of echo signals, several kinds of compressive sampling(CS) pulse-Doppler(CSPD) radar are developed with...Time-delay and Doppler shift estimation is a basic task for pulse-Doppler radar processing. For low-rate sampling of echo signals, several kinds of compressive sampling(CS) pulse-Doppler(CSPD) radar are developed with different analog-to-information conversion(AIC) systems. However, a unified metric is absent to evaluate their parameter estimation performance. Towards this end, this paper derives the deterministic Cramer-Rao bound(CRB)for the joint delay-Doppler estimation of CSPD radar to quantitatively analyze the estimate performance. Theoretical results reveal that the CRBs of both time-delays and Doppler shifts are inversely proportional to the received target signal-to-noise ratio(SNR), the number of transmitted pulses and the sampling rate of AIC systems. The main difference is that the CRB of Doppler shifts also lies on the coherent processing interval. Numerical experiments validate these theoretical results. They also show that the structure of the AIC systems has weak influence on the CRBs, which implies that the AIC structures can be flexibly selected for the implementation of CSPD radar.展开更多
This study discusses the scope of application of the Doppler backscattering(DBS)diagnostic for the tokamak with reactor technologies(TRT)project.This involved numerical modeling of the three-dimensional(3D)beam trajec...This study discusses the scope of application of the Doppler backscattering(DBS)diagnostic for the tokamak with reactor technologies(TRT)project.This involved numerical modeling of the three-dimensional(3D)beam trajectories.Calculations were performed to investigate the propagation of microwaves in the V(40–75 GHz)and W(75–110 GHz)frequency ranges with O-mode polarization for the density profile of the base TRT scenario.Our analysis showed that the DBS system antenna on the TRT would need to be tilted in both the poloidal and toroidal directions in order to meet the condition Kperp/Kpar<10%..For the DBS system located in the equatorial plane it was shown that a wide range of poloidal and toroidal angles is available for the successful implementation of the diagnostic to study the core,pedestal and scrape-off layer(SOL)regions.The DBS system located at 35 cm above the equatorial plane would be more limited in measurements only covering the SOL and pedestal regions.A shift of the cut-offs in the toroidal direction highlighted the need for 3D analysis of the DBS data.展开更多
A Langevin delayed fractional system with multiple delays in control,is a delayed fractional system that includes delay parameters in both state and control,is first introduced.This paper is devoted to investigating t...A Langevin delayed fractional system with multiple delays in control,is a delayed fractional system that includes delay parameters in both state and control,is first introduced.This paper is devoted to investigating the relative controllability of the Langevin delayed fractional system with multiple delays in control.For linear systems to be relatively controllable,necessary and sufficient circumstances are identified by introducing and employing the Gramian matrix.The sufficient conditions for the relative controllability of semilinear systems are ofered based on Schauder's fixed point theorem.As an unusual approach,the controllability results of the delayed system are built for the first time on the exact solution produced by the MittagLeffler type function although controllability ones in the literature are built on the Volterra integral equations or the mild solutions produced by resolvent families.展开更多
The collective dynamic of a fractional-order globally coupled system with time delays and fluctuating frequency is investigated.The power-law memory of the system is characterized using the Caputo fractional derivativ...The collective dynamic of a fractional-order globally coupled system with time delays and fluctuating frequency is investigated.The power-law memory of the system is characterized using the Caputo fractional derivative operator.Additionally,time delays in the potential field force and coupling force transmission are both considered.Firstly,based on the delay decoupling formula,combined with statistical mean method and the fractional-order Shapiro–Loginov formula,the“statistic synchronization”among particles is obtained,revealing the statistical equivalence between the mean field behavior of the system and the behavior of individual particles.Due to the existence of the coupling delay,the impact of the coupling force on synchronization exhibits non-monotonic,which is different from the previous monotonic effects.Then,two kinds of theoretical expression of output amplitude gains G and G are derived by time-delay decoupling formula and small delay approximation theorem,respectively.Compared to G,G is an exact theoretical solution,which means that G is not only more accurate in the region of small delay,but also applies to the region of large delay.Finally,the study of the output amplitude gain G and its resonance behavior are explored.Due to the presence of the potential field delay,a new resonance phenomenon termed“periodic resonance”is discovered,which arises from the periodic matching between the potential field delay and the driving frequency.This resonance phenomenon is analyzed qualitatively and quantitatively,uncovering undiscovered characteristics in previous studies.展开更多
Orthogonal time frequency space(OTFS)can resist the Doppler effect and guarantee reliable communication in high-speed scenarios.However,the Doppler rate induced by the relative acceleration between the transmitter and...Orthogonal time frequency space(OTFS)can resist the Doppler effect and guarantee reliable communication in high-speed scenarios.However,the Doppler rate induced by the relative acceleration between the transmitter and receiver degrades the performance of the OTFS.So far,the impact of the Doppler rate on OTFS systems has not been addressed.In this paper,we first introduce the Doppler rate in the OTFS system and derive the delay-Doppler domain input-output relation.In addition,the impact of the Doppler rate on the effective delay-Doppler domain channel is characterized by utilizing the first mean value theorem for definite integrals to avoid complicated integrals.To mitigate the effect of the Doppler rate,a large-scale antenna array is arranged at the receiver to separate each path of the multi-path channel through a high-resolution spatial matched filter beamformer.Next,the Doppler rate estimation scheme for an arbitrary order Doppler rate is proposed based on the successive interference cancellation pattern and the maximization of the spectrum of the ratio of high-order moments between the received samples in the identified branch and the transmitted samples.Finally,the estimation accuracy of the Doppler rate and the error performance of the proposed transceiver are validated by the numerical results.展开更多
基金supported by the Russian Science Foundation (No. 25-13-00300)the Centre for Optical and Laser Materials Research (SPbSU) and Saint Petersburg State University for measuring the quantum yields of luminescence within the framework of research project(No.125021902439-8)。
文摘The development of polymeric materials that exhibit blue thermally activated delayed fluorescence(TADF)is of great interest for optoelectronic applications.However,achieving TADF in polymers often requires an elaborate monomer design.The high-energy local triplet state(^(3)LE)of carbazole complicates its application despite the molecular orbital arrangement being suitable for blue emission.Here,we present an approach to polymer design that makes it possible to solve this problem.We demonstrate the in situ formation of a TADF donor-acceptor system during Suzuki polycondensation,creating an extended carbazole-based donor matrix coupled with a triazine acceptor.The resulting polymer exhibited efficient TADF with a low energy gap(ΔE_(ST))value if a phenyl N-substituent,enabling essential electron delocalization,was present in the carbazole moiety.This work establishes a versatile platform for developing carbazole-based TADF polymers,overcoming the fundamental limitations that hinder their widespread application.
文摘Delayed wound healing following radical gastrectomy remains an important yet underappreciated complication that prolongs hospitalization,increases costs,and undermines patient recovery.In An et al’s recent study,the authors present a machine learning-based risk prediction approach using routinely available clinical and laboratory parameters.Among the evaluated algorithms,a decision tree model demonstrated excellent discrimination,achieving an area under the curve of 0.951 in the validation set and notably identifying all true cases of delayed wound healing at the Youden index threshold.The inclusion of variables such as drainage duration,preoperative white blood cell and neutrophil counts,alongside age and sex,highlights the pragmatic appeal of the model for early postoperative monitoring.Nevertheless,several aspects warrant critical reflection,including the reliance on a postoperative variable(drainage duration),internal validation only,and certain reporting inconsistencies.This letter underscores both the promise and the limitations of adopting interpretable machine learning models in perioperative care.We advocate for transparent reporting,external validation,and careful consideration of clinically actionable timepoints before integration into practice.Ultimately,this work represents a valuable step toward precision risk stratification in gastric cancer surgery,and sets the stage for multicenter,prospective evaluations.
基金supported by the National Natural Science Foundation of China(Grant Nos.42407267 and 52374152)the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20220975).
文摘Time-delayed blasting is widely utilized in engineering to mitigate induced vibration hazards and enhance fragmentation.The underlying vibration reduction principle is the decrease of the charge weight per delay,while the potential for further vibration reduction remains debated,largely due to unclear underlying mechanisms.In light of the popularization of electronic detonators and the representativeness of double-hole configurationsfor multiple blastholes,it is essential to investigate the vibration characteristics induced by time-delayed double blastholes.Therefore,a series of doubleborehole experimental blasts was conducted in an underground roadway to clarify the variation in vibration from single-hole to dual-hole conditions.Based on the experimental data and inherent limitations,an exact full-fieldtheoretical model was further employed to systematically analyze the effects of delay time,charge length,and borehole inclination angle on vibrations induced by various doublehole configurations.The experimental data and theoretical analysis reveal that the general scaled distance effectively predicts vibrations in delayed blasting but does not reflectvibration reduction.Increasing delay time causes fluctuatingPPVs,which stabilize slightly above single-hole PPVs as delay times exceed a certain value.The delayed blasting primarily reduces near-fieldfrequencies.Longer charge lengths in double boreholes increase PPV levels and attenuation rates within a certain length,and the vibration behavior of combined long and short charge lengths is governed by the long blasthole.Larger blasthole inclination angles enhance vibration amplitude and reduce PPV attenuation rates.Optimizing inclination angles is more critical than adjusting delay times,and parallel boreholes offer the best vibration control.
文摘A series of blue and blue‑green Ir(Ⅲ)complexes has been investigated theoretically to explore their electronic structures,photophysical properties,efficiency roll‑off effect,and thermal activation delayed fluorescence(TADF)properties.All calculations were performed using density functional theory(DFT)and time‑dependent density functional theory(TDDFT).Calculations for electronic structures,frontier molecular orbital characteristics(which determine the efficiency roll‑off effect of the complexes),and photophysical properties were conducted using the Gaussian 09 software package.The calculation of spin‑orbit coupling matrix elements<T|HSOC|S>,which determine the TADF properties of the complexes,was performed using the ORCA software package.The calculation results show that the auxiliary ligand tetraphenylimidodiphosphinate(tpip),a strong electron‑withdrawing group,can mitigate the efficiency roll‑off effect of the complex.Furthermore,TADF is observed in one of the designed complexes,(F_(3)Phppy)_(2)Ir(tpip),where F_(3)Phppy=2‑[4‑(2,4,6‑trifluorophenyl)phenyl]pyridine.
基金supported by the National Natural Science Foundation of China,Nos.81701040(to HM),82071180(to HM),82271206(to TL),82171191(to YW),82371211(to YW)the Natural Science Foundation of Beijing,No.7212023(to HM)Key Subject of the Natural Science Foundation ofJiangsu Province for Colleges and Universities,No.23KJA320009(to YW).
文摘Delayed neurocognitive recovery following anesthesia and surgery is a common complication in older adult patients.Synapses are fundamental to cognitive function.The activity of synapses heavily depends on the energy supplied by synaptic mitochondria,which are significantly influenced by oxidative stress.Sirtuin 3 is a histone deacetylase located in the mitochondrial matrix that plays a pivotal role in regulating mitochondrial function.However,it remains unclear whether and how sirtuin 3 is involved in the development of delayed cognitive recovery.Therefore,in this study,we investigated the potential role of sirtuin 3 in synapses during delayed neurocognitive recovery.Our results showed that anesthesia and surgery induced cognitive impairment in mice and reduced sirtuin 3 protein expression.Overexpression of sirtuin 3 inhibited opening of the mitochondrial permeability transition pore by reducing acetylation of K166 on cyclophilin D and also rescued cognitive impairment.Aged mice carrying the cyclophilin D-K166R mutation exhibited significantly reduced cognitive impairment.Similarly,administering the mitochondrial permeability transition pore blocker,cyclosporine A,effectively alleviated the decline in synaptic mitochondrial function and cognitive impairment caused by anesthesia and surgery in aged mice.These results indicate that the sirtuin 3/cyclophilin D-K166/mPTP signaling pathway in hippocampal synaptic mitochondria is involved in delayed neurocognitive recovery of aged mice,suggesting this pathway could serve as a potential target for treatment.
基金supported by the National Natural Science Foundation of China (61703433)。
文摘Time delay and Doppler shift between the echo signal and the reference signal are two most commonly used measurements in target localization for the passive radar. Doppler rate, which can be obtained from the extended cross ambiguity function, offers an opportunity to further enhance the localization accuracy. This paper considers using the measurement Doppler rate in addition to measurements of time delay and Doppler shift to locate a moving target. A closed-form solution is developed to accurately and efficiently estimate the target position and velocity.The proposed solution establishes a pseudolinear set of equations by introducing some additional variables, imposes weighted least squares formulation to yield a rough estimate, and utilizes the function relation among the target location parameters and additional variables to improve the estimation accuracy. Theoretical covariance and Cramer-Rao lower bound(CRLB) are derived and compared, analytically indicating that the proposed solution attains the CRLB. Numerical simulations corroborate this analysis and demonstrate that the proposed solution outperforms existing methods.
文摘The proposed Doppler measurement technique shows that the Doppler measurements can be accomplished by a single pulse with multiple frequency components through optical fibre delay lines.Range and velocity ambiguity can be removed,and the velocity resolution can be improved dramatically by using long optical fibre delay lines.Furthermore,the velocity resolution can be modified by adjusting the length of optical fibre delay lines.In addition,the proposed radar can achieve high range resolution by using a single wideband pulse.As a result,the new approach can improve radar performance significantly.
文摘As an advanced device for observing atmospheric winds,the spaceborne Doppler Asymmetric Spatial Heterodyne(DASH)interferometer also encounters challenges associated with phase distortion,par-ticularly in limb sounding scenarios.This paper discusses interferogram modeling and phase distortion cor-rection techniques for spaceborne DASH interferometers.The modeling of phase distortion interferograms with and without Doppler shift for limb observation was conducted,and the effectiveness of the analytical expression was verified through numerical simulation.The simulation results indicate that errors propagate layer by layer while using the onion-peeling inversion algorithm to handle phase-distorted interferograms.In contrast,the phase distortion correction algorithm can achieve effective correction.This phase correction method can be successfully applied to correct phase distortions in the interferograms of the spaceborne DASH interferometer,providing a feasible solution to enhance its measurement accuracy.
文摘Deep neural networks(DNNs)are effective in solving both forward and inverse problems for nonlinear partial differential equations(PDEs).However,conventional DNNs are not effective in handling problems such as delay differential equations(DDEs)and delay integrodifferential equations(DIDEs)with constant delays,primarily due to their low regularity at delayinduced breaking points.In this paper,a DNN method that combines multi-task learning(MTL)which is proposed to solve both the forward and inverse problems of DIDEs.The core idea of this approach is to divide the original equation into multiple tasks based on the delay,using auxiliary outputs to represent the integral terms,followed by the use of MTL to seamlessly incorporate the properties at the breaking points into the loss function.Furthermore,given the increased training dificulty associated with multiple tasks and outputs,we employ a sequential training scheme to reduce training complexity and provide reference solutions for subsequent tasks.This approach significantly enhances the approximation accuracy of solving DIDEs with DNNs,as demonstrated by comparisons with traditional DNN methods.We validate the effectiveness of this method through several numerical experiments,test various parameter sharing structures in MTL and compare the testing results of these structures.Finally,this method is implemented to solve the inverse problem of nonlinear DIDE and the results show that the unknown parameters of DIDE can be discovered with sparse or noisy data.
基金supported by the National Natural Science Foundation of China under Grant U21A20449in part by Jiangsu Provincial Key Research and Development Program under Grant BE2021013-2。
文摘Wireless communication-enabled Cooperative Adaptive Cruise Control(CACC)is expected to improve the safety and traffic capacity of vehicle platoons.Existing CACC considers a conventional communication delay with fixed Vehicular Communication Network(VCN)topologies.However,when the network is under attack,the communication delay may be much higher,and the stability of the system may not be guaranteed.This paper proposes a novel communication Delay Aware CACC with Dynamic Network Topologies(DADNT).The main idea is that for various communication delays,in order to maximize the traffic capacity while guaranteeing stability and minimizing the following error,the CACC should dynamically adjust the VCN network topology to achieve the minimum inter-vehicle spacing.To this end,a multi-objective optimization problem is formulated,and a 3-step Divide-And-Conquer sub-optimal solution(3DAC)is proposed.Simulation results show that with 3DAC,the proposed DADNT with CACC can reduce the inter-vehicle spacing by 5%,10%,and 14%,respectively,compared with the traditional CACC with fixed one-vehicle,two-vehicle,and three-vehicle look-ahead network topologies,thereby improving the traffic efficiency.
基金supported by Fund of State Key Laboratory of IPOC(BUPT)(No.IPOC2021ZT16),China.
文摘The integrated optical true time delay phased array antenna system has the advantages of high bandwidth,small size,low loss and strong antiinterference capability,etc.The high integration of the optically controlled phased array antenna system is a necessary trend for the future development of the phased array,and it is also a major focus and difficulty in the current research of integrated microwave photonics.This paper firstly introduces the basic principle and development history of optical true time delay phased array antenna system based on microwave photonics,and briefly introduces the main implementation methods and integration platform of optical true time delay.Then,the application and development prospect of optical true time delay technology in beam control of phased array antenna system are mainly presented.Finally,according to the current research progress,the possible research directions of integrated optically controlled phased array antenna systems in the future are proposed.
基金supported by National Natural Science Foundation of China(No.61973234)Tianjin Science and Technology Plan Project(No.22YDTPJC00090)。
文摘To address the issue of low measurement accuracy caused by noise interference in the acquisition of low fluid flow rate signals with ultrasonic Doppler flow meters,a novel signal processing algorithm that combines ensemble empirical mode decomposition(EEMD)and cross-correlation algorithm was proposed.Firstly,a fast Fourier transform(FFT)spectrum analysis was utilized to ascertain the frequency range of the signal.Secondly,data acquisition was conducted at an appropriate sampling frequency,and the acquired Doppler flow rate signal was then decomposed into a series of intrinsic mode functions(IMFs)by EEMD.Subsequently,these decomposed IMFs were recombined based on their energy entropy,and then the noise of the recombined Doppler flow rate signal was removed by cross-correlation filtering.Finally,an ideal ultrasonic Doppler flow rate signal was extracted.Simulation and experimental verification show that the proposed Doppler flow signal processing method can effectively enhance the signal-to-noise ratio(SNR)and extend the lower limit of measurement of the ultrasonic Doppler flow meter.
基金Supported by the National Natural Science Foundation of China(12261050)Science and Technology Project of Department of Education of Jiangxi Province(GJJ2201612 and GJJ211027)Natural Science Foundation of Jiangxi Province of China(20212BAB202021)。
文摘In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave solutions for this model under the influence of advection term and distributed delay.The obtained results indicate that weak kernel and strong kernel can both deduce the existence of periodic traveling wave solutions.Finally,we apply the main results in this paper to Logistic model and Nicholson’s blowflies model.
基金supported by the National Natural Science Foundation of China(6140121061571228)
文摘Time-delay and Doppler shift estimation is a basic task for pulse-Doppler radar processing. For low-rate sampling of echo signals, several kinds of compressive sampling(CS) pulse-Doppler(CSPD) radar are developed with different analog-to-information conversion(AIC) systems. However, a unified metric is absent to evaluate their parameter estimation performance. Towards this end, this paper derives the deterministic Cramer-Rao bound(CRB)for the joint delay-Doppler estimation of CSPD radar to quantitatively analyze the estimate performance. Theoretical results reveal that the CRBs of both time-delays and Doppler shifts are inversely proportional to the received target signal-to-noise ratio(SNR), the number of transmitted pulses and the sampling rate of AIC systems. The main difference is that the CRB of Doppler shifts also lies on the coherent processing interval. Numerical experiments validate these theoretical results. They also show that the structure of the AIC systems has weak influence on the CRBs, which implies that the AIC structures can be flexibly selected for the implementation of CSPD radar.
基金financial support of the Ministry of Science and Higher Education of the Russian Federation in the framework of the state contract in the field of science(No.FSEG-2024-0005)。
文摘This study discusses the scope of application of the Doppler backscattering(DBS)diagnostic for the tokamak with reactor technologies(TRT)project.This involved numerical modeling of the three-dimensional(3D)beam trajectories.Calculations were performed to investigate the propagation of microwaves in the V(40–75 GHz)and W(75–110 GHz)frequency ranges with O-mode polarization for the density profile of the base TRT scenario.Our analysis showed that the DBS system antenna on the TRT would need to be tilted in both the poloidal and toroidal directions in order to meet the condition Kperp/Kpar<10%..For the DBS system located in the equatorial plane it was shown that a wide range of poloidal and toroidal angles is available for the successful implementation of the diagnostic to study the core,pedestal and scrape-off layer(SOL)regions.The DBS system located at 35 cm above the equatorial plane would be more limited in measurements only covering the SOL and pedestal regions.A shift of the cut-offs in the toroidal direction highlighted the need for 3D analysis of the DBS data.
文摘A Langevin delayed fractional system with multiple delays in control,is a delayed fractional system that includes delay parameters in both state and control,is first introduced.This paper is devoted to investigating the relative controllability of the Langevin delayed fractional system with multiple delays in control.For linear systems to be relatively controllable,necessary and sufficient circumstances are identified by introducing and employing the Gramian matrix.The sufficient conditions for the relative controllability of semilinear systems are ofered based on Schauder's fixed point theorem.As an unusual approach,the controllability results of the delayed system are built for the first time on the exact solution produced by the MittagLeffler type function although controllability ones in the literature are built on the Volterra integral equations or the mild solutions produced by resolvent families.
基金supported by the Natural Science Foundation of Sichuan Province,China(Youth Science Foundation)(Grant No.2022NSFSC1952).
文摘The collective dynamic of a fractional-order globally coupled system with time delays and fluctuating frequency is investigated.The power-law memory of the system is characterized using the Caputo fractional derivative operator.Additionally,time delays in the potential field force and coupling force transmission are both considered.Firstly,based on the delay decoupling formula,combined with statistical mean method and the fractional-order Shapiro–Loginov formula,the“statistic synchronization”among particles is obtained,revealing the statistical equivalence between the mean field behavior of the system and the behavior of individual particles.Due to the existence of the coupling delay,the impact of the coupling force on synchronization exhibits non-monotonic,which is different from the previous monotonic effects.Then,two kinds of theoretical expression of output amplitude gains G and G are derived by time-delay decoupling formula and small delay approximation theorem,respectively.Compared to G,G is an exact theoretical solution,which means that G is not only more accurate in the region of small delay,but also applies to the region of large delay.Finally,the study of the output amplitude gain G and its resonance behavior are explored.Due to the presence of the potential field delay,a new resonance phenomenon termed“periodic resonance”is discovered,which arises from the periodic matching between the potential field delay and the driving frequency.This resonance phenomenon is analyzed qualitatively and quantitatively,uncovering undiscovered characteristics in previous studies.
基金supported in part by the Fundamental Research Funds for the Central Universities under Grant No.2022JBQY004the National Natural Science Foundation of China under Grant Nos.62471026 and 62221001+3 种基金the Zhongguancun Xin Xi Disruptive Technology Innovation Foundation under Grant No.ZZ-2024-001the Joint Funds for Railway Fundamental Research of National Natural Science Foundation of China under Grant No.U2368201the Postdoctoral Fellowship Program and China Postdoctoral Science Foundation BX20240471ZTE Industry-University-Institute Cooperation Funds under Grant No.HC-CN-03-2019-12。
文摘Orthogonal time frequency space(OTFS)can resist the Doppler effect and guarantee reliable communication in high-speed scenarios.However,the Doppler rate induced by the relative acceleration between the transmitter and receiver degrades the performance of the OTFS.So far,the impact of the Doppler rate on OTFS systems has not been addressed.In this paper,we first introduce the Doppler rate in the OTFS system and derive the delay-Doppler domain input-output relation.In addition,the impact of the Doppler rate on the effective delay-Doppler domain channel is characterized by utilizing the first mean value theorem for definite integrals to avoid complicated integrals.To mitigate the effect of the Doppler rate,a large-scale antenna array is arranged at the receiver to separate each path of the multi-path channel through a high-resolution spatial matched filter beamformer.Next,the Doppler rate estimation scheme for an arbitrary order Doppler rate is proposed based on the successive interference cancellation pattern and the maximization of the spectrum of the ratio of high-order moments between the received samples in the identified branch and the transmitted samples.Finally,the estimation accuracy of the Doppler rate and the error performance of the proposed transceiver are validated by the numerical results.
