With the increase of China’s bond issuance and slowdown of the economic growth,the potential credit risks such as bond default in the bond market are gradually emerging.The frequent occurrence of bond defaults and th...With the increase of China’s bond issuance and slowdown of the economic growth,the potential credit risks such as bond default in the bond market are gradually emerging.The frequent occurrence of bond defaults and the problem of false credit ratings make bond investors and market participants more cautious about the credit ratings issued by rating agencies.Based on the default bonds from 2016 to 2019,this paper analyzes the adjustment of rating of defaulted bonds by rating agencies before default.It also compares the impact of both the regulatory events and the entrance of international agencies on timeless of credit ratings on default bonds.At the same time,the divergence of rating timeliness between different rating agencies is compared.The research shows that after the unified supervision of regulators and the punishment of Dagong Global Credit Rating Co.Ltd in 2018,the timeliness of rating agencies'downgrading of defaulted bonds has increased significantly;Compared with other rating agencies,the timeliness of rating agencies owned by international rating agencies are better.展开更多
In this paper we analyze the main characteristics of correlative clients and the revolver loan and reduced form models for the correlative clients A and B in real-life. This is done by decomposing the default intensit...In this paper we analyze the main characteristics of correlative clients and the revolver loan and reduced form models for the correlative clients A and B in real-life. This is done by decomposing the default intensity into specific default intensity and homogenous default intensity. We also use a mathematical formula of the default joint distribution function and the marginal distribution function in the physical measure to deduce the martingale measure. The modeling idea on pricing the revolver loan with client A is presented by applying reduced form model. Through calculating the cost and income fund flows under the martingale measure, the framework of a “break-even” pricing model is established. The conclusion is that the interest rate of a revolver loan for client A on the “break-even” point is not related to the maximum authorized amount and the drawdown amount at that time under some assumptions, but only rests with credit rating and homogenous default intensity of client A and B as well as loan term of client A.展开更多
Home mortgage loan lending firms are exposed to many business risks.This paper focuses on the mortgage loan borrower risks and proposes a prospective loss analysis approach in regard to loan repayment defaults of borr...Home mortgage loan lending firms are exposed to many business risks.This paper focuses on the mortgage loan borrower risks and proposes a prospective loss analysis approach in regard to loan repayment defaults of borrowers.For this purpose,a predictive modeling is presented in three stages.In the first stage,occurrence of borrower defaults in a mortgage loans portfolio is modeled through the generalized linear models(GLMs)type regressions for which we specify a logistic distribution for default events.The second stage of modeling develops a survival analysis in order to estimate survival probability and hazard rate functions for individual loans.Ultimately,an expectable loss amount model is presented in the third stage as a function of conditional survival probabilities and corresponding hazard rates at loan levels.Throughout all modeling stages,a large and real data set is used as an empirical analysis case by which detailed interpretations and practical implications of the obtained results are stated.展开更多
Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the u...Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.展开更多
Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation(iTBS)and hinders the identification of predictive factors.This study investigated functional network con...Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation(iTBS)and hinders the identification of predictive factors.This study investigated functional network connectivity and predictors of iTBS treatment outcomes in adolescents and young adults with depression.Aim This study aimed to identify default mode network(DMN)-based connectivity patterns associated with varying iTBS treatment outcomes in depression.Methods Data from a randomised controlled trial of iTBS in depression(n=82)were analysed using a data-driven approach to classify homogeneous subgroups based on the DMN.Connectivity subgroups were compared on depressive symptoms and cognitive function at pretreatment and post-treatment.Furthermore,the predictive significance of baseline inflammatory cytokines on post-treatment outcomes was evaluated.Results Two distinct subgroups were identified.Subgroup 1 exhibited high heterogeneity and greater centrality in the posterior cingulate cortex and retrosplenial cortex,while subgroup 2 showed more homogeneous connectivity patterns and greater centrality in the temporoparietal junction and posterior inferior parietal lobule.No main effect for subgroup,treatment or subgroup×treatment interaction was revealed in the improvement of depressive symptoms.A significant subgroup×treatment interaction related to symbol coding improvement was detected(F=5.22,p=0.026).Within subgroup 1,the active group showed significantly greater improvement in symbol coding compared with the sham group(t=2.30,p=0.028),while baseline levels of interleukin-6 and C-reactive protein emerged as significant indicators for predicting improvements in symbolic coding(R2=0.35,RMSE(root-mean-square error)=5.72,p=0.013).Subgroup 2 showed no significant findings in terms of cognitive improvement or inflammatory cytokines predictions.展开更多
BACKGROUND Currently,adolescent depression is one of the most significant public health concerns,markedly influencing emotional,cognitive,and social maturation.Despite advancements in distinguish the neurobiological s...BACKGROUND Currently,adolescent depression is one of the most significant public health concerns,markedly influencing emotional,cognitive,and social maturation.Despite advancements in distinguish the neurobiological substrates underlying depression,the intricate patterns of disrupted brain network connectivity in adolescents warrant further exploration.AIM To elucidate the neural correlates of adolescent depression by examining brain network connectivity using resting-state functional magnetic resonance imaging(rs-fMRI).METHODS The study cohort comprised 74 depressed adolescents and 59 healthy controls aged 12 to 17 years.Participants underwent rs-fMRI to evaluate functional connectivity within and across critical brain networks,including the visual,default mode network(DMN),dorsal attention,salience,somatomotor,and frontoparietal control networks.RESULTS Analyses revealed pronounced functional disparities within key neural circuits among adolescents with depression.The results demonstrated existence of hemispheric asymmetries characterized by enhanced activity in the left visual network,which contrasted the diminished activity in the right hemisphere.The DMN facilitated increased activity within the left prefrontal cortex and reduced engagement in the right hemisphere,implicating disrupted self-referential and emotional processing mechanisms.Additionally,an overactive right dorsal attention network and a hypoactive salience network were identified,underscoring significant abnormalities in attentional and emotional regulation in adolescent depression.CONCLUSION The findings from this study underscore distinct neural connectivity disruptions in adolescent depression,underscoring the critical role of specific neurobiological markers for precise early diagnosis of adolescent depression.The observed functional asymmetries and network-specific deviations elucidate the complex neurobiological architecture of adolescent depression,supporting the development of targeted therapeutic strategies.展开更多
BACKGROUND Group cognitive behavioral therapy(GCBT)is increasingly being used to treat obsessive-compulsive disorder(OCD)because of its high efficiency,economy,and interaction among group members.However,the changes i...BACKGROUND Group cognitive behavioral therapy(GCBT)is increasingly being used to treat obsessive-compulsive disorder(OCD)because of its high efficiency,economy,and interaction among group members.However,the changes in network functional connectivity(FC)in patients with OCD with GCBT remain unclear.AIM To investigate inter-and intra-network resting-state FC(rs-FC)abnormalities before and after GCBT in unmedicated patients with OCD and validate the efficacy of GCBT.METHODS Overall,33 individuals with OCD and 26 healthy controls underwent resting-state functional magnetic resonance imaging.The patients were rescanned 12 weeks after GCBT.Four cognition-related networks-default mode network(DMN),dorsal attention network(DAN),salience network(SAN),and frontoparietal network(FPN)-were selected to examine FC abnormalities within and between OCD networks before and after GCBT.Neuropsychological assessments including memory,executive function,speech,attention,and visuospatial ability were reassessed following GCBT.Pearson’s correlations were used to analyze the relationship between aberrant FC in cognition-related networks and altered neuropsychological assessments in patients.RESULTS Rs-FC within the DMN and DAN decreased significantly.Additionally,rs-FC between the DMN-DAN,DMNFPN,DMN-SAN,and DAN-SAN also decreased.Significant improvements were observed in cognitive functions,such as memory,executive function,attention,and visuospatial ability.Furthermore,reduced rs-FC within the DMN correlated with visuospatial ability and executive function;DAN positively correlated with Shape Trails Test(STT)-A test elapsed time;DMN-DAN negatively correlated with Rey-Osterrieth Complex Figure(Rey-O)mimicry time and the three elapsed times of the tower of Hanoi;DMN-SAN negatively correlated with Rey-O imitation time and positively correlated with STT-A test elapsed time;and DMN-FPN negatively correlated with Auditory Word Learning Test N1 and N4 scores.CONCLUSION Decreased rs-FC within the DMN and DAN,which correlated with executive function post-treatment,has potential as a neuroimaging marker to predict treatment response to GCBT in patients with OCD.展开更多
This paper provides the first empirical study on bond defaults in the Chinese market.It overcomes the deficiencies of existing methods,which suffer from lack of actual default data for back testing.With newly availabl...This paper provides the first empirical study on bond defaults in the Chinese market.It overcomes the deficiencies of existing methods,which suffer from lack of actual default data for back testing.With newly available bond default data,we analyze the roles of market variables against accounting variables under various models.While we find that Merton's market-based structural model and KMV's Distance to Default exhibit languid discriminating power compared with hazard models that have carefully constructed predictors,other market variables carry significant information about bond defaults and could help improve on models with only the accounting variables.This implies that the collective intelligence of the market could somehow mitigate the distortion caused by misreported accounting information.Further,model performance can be significantly improved by adding predicting variables that link an individual financial measure to the broader market performance,such as the relative margin—a business environment proxy introduced in this study.We not only shed light on the default behavior of the Chinese bond market,but also provide a promising approach to improve the variable selection process.展开更多
In common sense reasoning two typical types of defaults are encoun- tered. One is of the form 'All birds can fly except b1, b2,…, and bm(m>1)' , and the other 'All birds can fly, but there exist except...In common sense reasoning two typical types of defaults are encoun- tered. One is of the form 'All birds can fly except b1, b2,…, and bm(m>1)' , and the other 'All birds can fly, but there exist exceptiona' . The first type of defaults is readily formalized but the other, as some researchers have noticed, is difficult to deal witb. This paper establisbes a geaeral scheme for formalising defaults of the two typea, the key to which is the introduction of a two-argument predicate ab(I,S) to represent exceptional objects.展开更多
This paper uses Renrendai data to study the relationship between monetaryj policy and the default behavior of borrowers,and analyzes the transmission channels.The research shows that tight monetary policy will lead to...This paper uses Renrendai data to study the relationship between monetaryj policy and the default behavior of borrowers,and analyzes the transmission channels.The research shows that tight monetary policy will lead to a significant increase in a borrower s probability to default,and this effect will continue for several months.There may be two transmission channels:(i)monetary policy changes a debtor s liquidity through credit and balance sheet channels,which directly affects their current repayment behavior;and(ii)monetary policy may affect a borrower s investment,production and profitability,thus changing their long-term solvency.The paper also finds that the repayment behavior of productive borrowers is more susceptible to monetary policy than consumptive borrowers,and that the default behavior of borrowers in coastal provinces is more susceptible to monetary policy than of borrowers in inland provinces.These findings provide new evidence for understanding how monetary policy affects individual behavior and its transmission mechanisms.展开更多
Attentional issues may affect acquiring new information, task performance, and learning. Cortical network activities change during different functional brain states, including the default mode network (DMN) and attent...Attentional issues may affect acquiring new information, task performance, and learning. Cortical network activities change during different functional brain states, including the default mode network (DMN) and attention network. We investigated the neural mechanisms underlying attentional functions and correlations between DMN connectivity and attentional function using the Trail-Making Test (TMT)-A and -B. Electroencephalography recordings were performed by placing 19 scalp electrodes per the 10 - 20 system. The mean power level was calculated for each rest and task condition. Non-parametric Spearman’s rank correlation was used to examine the correlation in power levels between the rest and TMT conditions. The most significant correlations during TMT-A were observed in the high gamma wave, followed by theta and beta waves, indicating that most correlations were in the parietal lobe, followed by the frontal, central, and temporal lobes. The most significant correlations during TMT-B were observed in the beta wave, followed by the high and low gamma waves, indicating that most correlations were in the temporal lobe, followed by the parietal, frontal, and central lobes. Frontoparietal beta and gamma waves in the DMN may represent attentional functions.展开更多
Background: Defaulting on antiretroviral therapy has been identified as the most important factor contributing to the antiretroviral therapy failure rate. This study aimed to investigate factors associated with defaul...Background: Defaulting on antiretroviral therapy has been identified as the most important factor contributing to the antiretroviral therapy failure rate. This study aimed to investigate factors associated with defaulting on antiretroviral therapy among adult patients receiving care at Chikankata Mission Hospital antiretroviral therapy clinic. Method: Cross-sectional analytical study on 385 participants selected by a computer generated random numbers technique of simple random sampling from among the patients receiving antiretroviral therapy at Chikankata Mission Hospital. Data collected were processed and analysed using Statistical Package for Social Science version 27. Univariate and backward multivariable logistic regression analysis was performed to identify factors associated with antiretroviral therapy defaulting. The level of significance was set at 5% with a confidence level of 95%. Results: Over half (58.4%) of the study participants defaulted on antiretroviral therapy. About 65.8% of study participants indicated improved health as the reason they defaulted on antiretroviral therapy. Most participants indicated that it was important to always go for antiretroviral therapy services (Adjusted Odds Ratio 1.95;95% Confidence Interval: [1.14 - 3.33], p = 0.015). Very few participants indicated poor family support for antiretroviral therapy services (Adjusted Odds Ratio 4.08;95% Confidence Interval: [2.02 - 8.23], p Conclusion: Defaulting on antiretroviral therapy continues to be a significant problem and needs to be addressed as a matter of priority. More counselling and awareness-raising programmes are required to improve knowledge and understanding on the importance of attending scheduled antiretroviral therapy clinics and services as well as the consequences of defaulting on antiretroviral therapy.展开更多
We have shown that cornerstone articles considering effects of corporate debt on the firm value and constituting the basis of the trade-off theory of capital structure are wrong.Their main mistake is in ignoring the b...We have shown that cornerstone articles considering effects of corporate debt on the firm value and constituting the basis of the trade-off theory of capital structure are wrong.Their main mistake is in ignoring the business securing expenses(BSEs).In the framework of the extended Merton model(EMM),we consider the cumulative effect of debt and corporate taxes on the firm value and its survival,in other words,we revisit Modigliani-Miller Proposition 3(MMP3).We show that(1)debt affects the firm value and its survival,(2)this effect is negative,diminishing the firm value and its chances to survive,(3)the pressure increases as the debt grows provoking the firm’s default,(4)the main factors depressing the levered firm are its debt payments added to the BSEs of the identical unlevered firm and the length of debt maturity,(5)corporate taxes cause development of positive skewness in the asset distribution,but do not affect the location of this distribution in the asset axis.The presented model helps estimate the consequences of choosing this or that level of debt in the presence of corporate taxes and can make a useful instrument for practicing financial managers.展开更多
This study developed several machine learning models to predict defaults in the invoice-trading peer-to-business(P2B)market.Using techniques such as logistic regression,conditional inference trees,random forests,suppo...This study developed several machine learning models to predict defaults in the invoice-trading peer-to-business(P2B)market.Using techniques such as logistic regression,conditional inference trees,random forests,support vector machines,and neural networks,the prediction of the default rate was evaluated.The results showed that these techniques can effectively improve the detection of defaults by up to 56% while maintaining levels of specificity above 70%.Unlike other studies on the same topic,this was performed using sampling techniques to address the imbalance of classes and using different time periods for the training and test datasets to ensure intertemporal validation and realistic predictions.For the first-time,default explainability in the invoice-trading market was studied by examining the impact of macroeconomic factors and invoice characteristics.The findings highlighted that gross domestic product,exports,trade type,and trade bands are significant factors that explain defaults.Furthermore,the pricing mechanisms of P2B platforms were evaluated with the observed and implicit probabilities of the default to analyze the price risk adjustment.The results showed that price reflects a significantly higher implicit probability of default than observed default,which in turn suggests that underlying factors exist besides the borrowers’probability of default.展开更多
This paper investigates the theoretical relationship between corporate governance,fair value accounting,and debt contracts.It primarily examines the individual impacts of corporate governance and fair value accounting...This paper investigates the theoretical relationship between corporate governance,fair value accounting,and debt contracts.It primarily examines the individual impacts of corporate governance and fair value accounting on debt contracts,while also exploring the influence of corporate governance on fair value accounting.The study emphasizes the importance of considering the interests and legal status of creditors in the context of debt contracts.The findings indicate that strong corporate governance can reduce the likelihood of debt default and that the company’s restructuring costs in the event of a default determine whether improved corporate governance will increase or decrease debt costs.Additionally,the study reveals that the strength of corporate governance affects the value relevance of fair value accounting.However,the impact of fair value accounting on debt contracts is not inherently positive or negative;for instance,companies may use fair value adjustments with manipulative intent to enhance performance.Ultimately,the research highlights that discussions about corporate governance should not prioritize shareholder interests exclusively but also consider the legitimate position of creditors.展开更多
This paper investigates the macroeconomic impacts of Internet finance,highlighting its advantages and challenges.Internet finance,a fusion of Internet technology with traditional financial practices,introduces innovat...This paper investigates the macroeconomic impacts of Internet finance,highlighting its advantages and challenges.Internet finance,a fusion of Internet technology with traditional financial practices,introduces innovative models for global asset management,capital financing,payments,investments,and intermediary services.While it enhances the accessibility and efficiency of financial services,it also introduces new risks,such as higher credit default rates.This study explores how Internet finance contributes to financial inclusivity and macroeconomic growth yet poses potential threats to traditional financial stability.The dual aspects of Internet finance are analyzed:its application in existing processes and its capacity to generate novel business models.Furthermore,the paper proposes strategic responses to mitigate the negative impacts of Internet finance,mainly focusing on risk management and regulatory improvements to safeguard economic stability.展开更多
presented The conceptions of abstract default reasoning frameworks （ADRFs） and D-consequence relations are Based on representation properties of D-consequence relations, it proves that any cumulative nonmonotonic co...presented The conceptions of abstract default reasoning frameworks （ADRFs） and D-consequence relations are Based on representation properties of D-consequence relations, it proves that any cumulative nonmonotonic consequence relation with the connective-free form can be represented by ADRFs.展开更多
文摘With the increase of China’s bond issuance and slowdown of the economic growth,the potential credit risks such as bond default in the bond market are gradually emerging.The frequent occurrence of bond defaults and the problem of false credit ratings make bond investors and market participants more cautious about the credit ratings issued by rating agencies.Based on the default bonds from 2016 to 2019,this paper analyzes the adjustment of rating of defaulted bonds by rating agencies before default.It also compares the impact of both the regulatory events and the entrance of international agencies on timeless of credit ratings on default bonds.At the same time,the divergence of rating timeliness between different rating agencies is compared.The research shows that after the unified supervision of regulators and the punishment of Dagong Global Credit Rating Co.Ltd in 2018,the timeliness of rating agencies'downgrading of defaulted bonds has increased significantly;Compared with other rating agencies,the timeliness of rating agencies owned by international rating agencies are better.
文摘In this paper we analyze the main characteristics of correlative clients and the revolver loan and reduced form models for the correlative clients A and B in real-life. This is done by decomposing the default intensity into specific default intensity and homogenous default intensity. We also use a mathematical formula of the default joint distribution function and the marginal distribution function in the physical measure to deduce the martingale measure. The modeling idea on pricing the revolver loan with client A is presented by applying reduced form model. Through calculating the cost and income fund flows under the martingale measure, the framework of a “break-even” pricing model is established. The conclusion is that the interest rate of a revolver loan for client A on the “break-even” point is not related to the maximum authorized amount and the drawdown amount at that time under some assumptions, but only rests with credit rating and homogenous default intensity of client A and B as well as loan term of client A.
文摘Home mortgage loan lending firms are exposed to many business risks.This paper focuses on the mortgage loan borrower risks and proposes a prospective loss analysis approach in regard to loan repayment defaults of borrowers.For this purpose,a predictive modeling is presented in three stages.In the first stage,occurrence of borrower defaults in a mortgage loans portfolio is modeled through the generalized linear models(GLMs)type regressions for which we specify a logistic distribution for default events.The second stage of modeling develops a survival analysis in order to estimate survival probability and hazard rate functions for individual loans.Ultimately,an expectable loss amount model is presented in the third stage as a function of conditional survival probabilities and corresponding hazard rates at loan levels.Throughout all modeling stages,a large and real data set is used as an empirical analysis case by which detailed interpretations and practical implications of the obtained results are stated.
文摘Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.
基金supported by the Guangzhou Municipal Key Discipline in Medicine(2021-2023)the Guangzhou High-level Clinical Key Specialty,the Guangzhou Research-oriented Hospital,the Innovative Clinical Technique of Guangzhou(2024-2026)+6 种基金the Guangdong Basic and Applied Basic Research Foundation(grant number 2022A1515011567,2020A1515110565)the Guangzhou Science,Technology Planning Project(grant number 202201010714,202103000032)the National Natural Science Foundation of China(grant number 82471546)the Guangdong College Students Innovation and Entrepreneurship Training Project(grant number S202310570038)the Guangzhou Health Science and Technology Project(grant number 20231A010038)the Guangzhou Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine Technology Project(grant number:20232A010013)the Science and Technology Plan Project of Guangzhou(2023A03J0842).
文摘Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation(iTBS)and hinders the identification of predictive factors.This study investigated functional network connectivity and predictors of iTBS treatment outcomes in adolescents and young adults with depression.Aim This study aimed to identify default mode network(DMN)-based connectivity patterns associated with varying iTBS treatment outcomes in depression.Methods Data from a randomised controlled trial of iTBS in depression(n=82)were analysed using a data-driven approach to classify homogeneous subgroups based on the DMN.Connectivity subgroups were compared on depressive symptoms and cognitive function at pretreatment and post-treatment.Furthermore,the predictive significance of baseline inflammatory cytokines on post-treatment outcomes was evaluated.Results Two distinct subgroups were identified.Subgroup 1 exhibited high heterogeneity and greater centrality in the posterior cingulate cortex and retrosplenial cortex,while subgroup 2 showed more homogeneous connectivity patterns and greater centrality in the temporoparietal junction and posterior inferior parietal lobule.No main effect for subgroup,treatment or subgroup×treatment interaction was revealed in the improvement of depressive symptoms.A significant subgroup×treatment interaction related to symbol coding improvement was detected(F=5.22,p=0.026).Within subgroup 1,the active group showed significantly greater improvement in symbol coding compared with the sham group(t=2.30,p=0.028),while baseline levels of interleukin-6 and C-reactive protein emerged as significant indicators for predicting improvements in symbolic coding(R2=0.35,RMSE(root-mean-square error)=5.72,p=0.013).Subgroup 2 showed no significant findings in terms of cognitive improvement or inflammatory cytokines predictions.
基金Supported by the Medical Research Project of the Chongqing Municipal Health Commission,No.2024WSJK110.
文摘BACKGROUND Currently,adolescent depression is one of the most significant public health concerns,markedly influencing emotional,cognitive,and social maturation.Despite advancements in distinguish the neurobiological substrates underlying depression,the intricate patterns of disrupted brain network connectivity in adolescents warrant further exploration.AIM To elucidate the neural correlates of adolescent depression by examining brain network connectivity using resting-state functional magnetic resonance imaging(rs-fMRI).METHODS The study cohort comprised 74 depressed adolescents and 59 healthy controls aged 12 to 17 years.Participants underwent rs-fMRI to evaluate functional connectivity within and across critical brain networks,including the visual,default mode network(DMN),dorsal attention,salience,somatomotor,and frontoparietal control networks.RESULTS Analyses revealed pronounced functional disparities within key neural circuits among adolescents with depression.The results demonstrated existence of hemispheric asymmetries characterized by enhanced activity in the left visual network,which contrasted the diminished activity in the right hemisphere.The DMN facilitated increased activity within the left prefrontal cortex and reduced engagement in the right hemisphere,implicating disrupted self-referential and emotional processing mechanisms.Additionally,an overactive right dorsal attention network and a hypoactive salience network were identified,underscoring significant abnormalities in attentional and emotional regulation in adolescent depression.CONCLUSION The findings from this study underscore distinct neural connectivity disruptions in adolescent depression,underscoring the critical role of specific neurobiological markers for precise early diagnosis of adolescent depression.The observed functional asymmetries and network-specific deviations elucidate the complex neurobiological architecture of adolescent depression,supporting the development of targeted therapeutic strategies.
基金Supported by the Pharmaceutical Science and Technology Project of Zhejiang Province,No.2023RC266the Natural Science Foundation of Ningbo,No.202003N4266.
文摘BACKGROUND Group cognitive behavioral therapy(GCBT)is increasingly being used to treat obsessive-compulsive disorder(OCD)because of its high efficiency,economy,and interaction among group members.However,the changes in network functional connectivity(FC)in patients with OCD with GCBT remain unclear.AIM To investigate inter-and intra-network resting-state FC(rs-FC)abnormalities before and after GCBT in unmedicated patients with OCD and validate the efficacy of GCBT.METHODS Overall,33 individuals with OCD and 26 healthy controls underwent resting-state functional magnetic resonance imaging.The patients were rescanned 12 weeks after GCBT.Four cognition-related networks-default mode network(DMN),dorsal attention network(DAN),salience network(SAN),and frontoparietal network(FPN)-were selected to examine FC abnormalities within and between OCD networks before and after GCBT.Neuropsychological assessments including memory,executive function,speech,attention,and visuospatial ability were reassessed following GCBT.Pearson’s correlations were used to analyze the relationship between aberrant FC in cognition-related networks and altered neuropsychological assessments in patients.RESULTS Rs-FC within the DMN and DAN decreased significantly.Additionally,rs-FC between the DMN-DAN,DMNFPN,DMN-SAN,and DAN-SAN also decreased.Significant improvements were observed in cognitive functions,such as memory,executive function,attention,and visuospatial ability.Furthermore,reduced rs-FC within the DMN correlated with visuospatial ability and executive function;DAN positively correlated with Shape Trails Test(STT)-A test elapsed time;DMN-DAN negatively correlated with Rey-Osterrieth Complex Figure(Rey-O)mimicry time and the three elapsed times of the tower of Hanoi;DMN-SAN negatively correlated with Rey-O imitation time and positively correlated with STT-A test elapsed time;and DMN-FPN negatively correlated with Auditory Word Learning Test N1 and N4 scores.CONCLUSION Decreased rs-FC within the DMN and DAN,which correlated with executive function post-treatment,has potential as a neuroimaging marker to predict treatment response to GCBT in patients with OCD.
文摘This paper provides the first empirical study on bond defaults in the Chinese market.It overcomes the deficiencies of existing methods,which suffer from lack of actual default data for back testing.With newly available bond default data,we analyze the roles of market variables against accounting variables under various models.While we find that Merton's market-based structural model and KMV's Distance to Default exhibit languid discriminating power compared with hazard models that have carefully constructed predictors,other market variables carry significant information about bond defaults and could help improve on models with only the accounting variables.This implies that the collective intelligence of the market could somehow mitigate the distortion caused by misreported accounting information.Further,model performance can be significantly improved by adding predicting variables that link an individual financial measure to the broader market performance,such as the relative margin—a business environment proxy introduced in this study.We not only shed light on the default behavior of the Chinese bond market,but also provide a promising approach to improve the variable selection process.
文摘In common sense reasoning two typical types of defaults are encoun- tered. One is of the form 'All birds can fly except b1, b2,…, and bm(m>1)' , and the other 'All birds can fly, but there exist exceptiona' . The first type of defaults is readily formalized but the other, as some researchers have noticed, is difficult to deal witb. This paper establisbes a geaeral scheme for formalising defaults of the two typea, the key to which is the introduction of a two-argument predicate ab(I,S) to represent exceptional objects.
文摘This paper uses Renrendai data to study the relationship between monetaryj policy and the default behavior of borrowers,and analyzes the transmission channels.The research shows that tight monetary policy will lead to a significant increase in a borrower s probability to default,and this effect will continue for several months.There may be two transmission channels:(i)monetary policy changes a debtor s liquidity through credit and balance sheet channels,which directly affects their current repayment behavior;and(ii)monetary policy may affect a borrower s investment,production and profitability,thus changing their long-term solvency.The paper also finds that the repayment behavior of productive borrowers is more susceptible to monetary policy than consumptive borrowers,and that the default behavior of borrowers in coastal provinces is more susceptible to monetary policy than of borrowers in inland provinces.These findings provide new evidence for understanding how monetary policy affects individual behavior and its transmission mechanisms.
文摘Attentional issues may affect acquiring new information, task performance, and learning. Cortical network activities change during different functional brain states, including the default mode network (DMN) and attention network. We investigated the neural mechanisms underlying attentional functions and correlations between DMN connectivity and attentional function using the Trail-Making Test (TMT)-A and -B. Electroencephalography recordings were performed by placing 19 scalp electrodes per the 10 - 20 system. The mean power level was calculated for each rest and task condition. Non-parametric Spearman’s rank correlation was used to examine the correlation in power levels between the rest and TMT conditions. The most significant correlations during TMT-A were observed in the high gamma wave, followed by theta and beta waves, indicating that most correlations were in the parietal lobe, followed by the frontal, central, and temporal lobes. The most significant correlations during TMT-B were observed in the beta wave, followed by the high and low gamma waves, indicating that most correlations were in the temporal lobe, followed by the parietal, frontal, and central lobes. Frontoparietal beta and gamma waves in the DMN may represent attentional functions.
文摘Background: Defaulting on antiretroviral therapy has been identified as the most important factor contributing to the antiretroviral therapy failure rate. This study aimed to investigate factors associated with defaulting on antiretroviral therapy among adult patients receiving care at Chikankata Mission Hospital antiretroviral therapy clinic. Method: Cross-sectional analytical study on 385 participants selected by a computer generated random numbers technique of simple random sampling from among the patients receiving antiretroviral therapy at Chikankata Mission Hospital. Data collected were processed and analysed using Statistical Package for Social Science version 27. Univariate and backward multivariable logistic regression analysis was performed to identify factors associated with antiretroviral therapy defaulting. The level of significance was set at 5% with a confidence level of 95%. Results: Over half (58.4%) of the study participants defaulted on antiretroviral therapy. About 65.8% of study participants indicated improved health as the reason they defaulted on antiretroviral therapy. Most participants indicated that it was important to always go for antiretroviral therapy services (Adjusted Odds Ratio 1.95;95% Confidence Interval: [1.14 - 3.33], p = 0.015). Very few participants indicated poor family support for antiretroviral therapy services (Adjusted Odds Ratio 4.08;95% Confidence Interval: [2.02 - 8.23], p Conclusion: Defaulting on antiretroviral therapy continues to be a significant problem and needs to be addressed as a matter of priority. More counselling and awareness-raising programmes are required to improve knowledge and understanding on the importance of attending scheduled antiretroviral therapy clinics and services as well as the consequences of defaulting on antiretroviral therapy.
文摘We have shown that cornerstone articles considering effects of corporate debt on the firm value and constituting the basis of the trade-off theory of capital structure are wrong.Their main mistake is in ignoring the business securing expenses(BSEs).In the framework of the extended Merton model(EMM),we consider the cumulative effect of debt and corporate taxes on the firm value and its survival,in other words,we revisit Modigliani-Miller Proposition 3(MMP3).We show that(1)debt affects the firm value and its survival,(2)this effect is negative,diminishing the firm value and its chances to survive,(3)the pressure increases as the debt grows provoking the firm’s default,(4)the main factors depressing the levered firm are its debt payments added to the BSEs of the identical unlevered firm and the length of debt maturity,(5)corporate taxes cause development of positive skewness in the asset distribution,but do not affect the location of this distribution in the asset axis.The presented model helps estimate the consequences of choosing this or that level of debt in the presence of corporate taxes and can make a useful instrument for practicing financial managers.
基金the funding provided by the Galician Regional Government[ED431C 2020/18]co-funded by the European Regional Development Fund(ERDF/FEDER)within the period 2020-2023.
文摘This study developed several machine learning models to predict defaults in the invoice-trading peer-to-business(P2B)market.Using techniques such as logistic regression,conditional inference trees,random forests,support vector machines,and neural networks,the prediction of the default rate was evaluated.The results showed that these techniques can effectively improve the detection of defaults by up to 56% while maintaining levels of specificity above 70%.Unlike other studies on the same topic,this was performed using sampling techniques to address the imbalance of classes and using different time periods for the training and test datasets to ensure intertemporal validation and realistic predictions.For the first-time,default explainability in the invoice-trading market was studied by examining the impact of macroeconomic factors and invoice characteristics.The findings highlighted that gross domestic product,exports,trade type,and trade bands are significant factors that explain defaults.Furthermore,the pricing mechanisms of P2B platforms were evaluated with the observed and implicit probabilities of the default to analyze the price risk adjustment.The results showed that price reflects a significantly higher implicit probability of default than observed default,which in turn suggests that underlying factors exist besides the borrowers’probability of default.
文摘This paper investigates the theoretical relationship between corporate governance,fair value accounting,and debt contracts.It primarily examines the individual impacts of corporate governance and fair value accounting on debt contracts,while also exploring the influence of corporate governance on fair value accounting.The study emphasizes the importance of considering the interests and legal status of creditors in the context of debt contracts.The findings indicate that strong corporate governance can reduce the likelihood of debt default and that the company’s restructuring costs in the event of a default determine whether improved corporate governance will increase or decrease debt costs.Additionally,the study reveals that the strength of corporate governance affects the value relevance of fair value accounting.However,the impact of fair value accounting on debt contracts is not inherently positive or negative;for instance,companies may use fair value adjustments with manipulative intent to enhance performance.Ultimately,the research highlights that discussions about corporate governance should not prioritize shareholder interests exclusively but also consider the legitimate position of creditors.
文摘This paper investigates the macroeconomic impacts of Internet finance,highlighting its advantages and challenges.Internet finance,a fusion of Internet technology with traditional financial practices,introduces innovative models for global asset management,capital financing,payments,investments,and intermediary services.While it enhances the accessibility and efficiency of financial services,it also introduces new risks,such as higher credit default rates.This study explores how Internet finance contributes to financial inclusivity and macroeconomic growth yet poses potential threats to traditional financial stability.The dual aspects of Internet finance are analyzed:its application in existing processes and its capacity to generate novel business models.Furthermore,the paper proposes strategic responses to mitigate the negative impacts of Internet finance,mainly focusing on risk management and regulatory improvements to safeguard economic stability.
文摘presented The conceptions of abstract default reasoning frameworks （ADRFs） and D-consequence relations are Based on representation properties of D-consequence relations, it proves that any cumulative nonmonotonic consequence relation with the connective-free form can be represented by ADRFs.
