In this paper a generalized defaultable bond pricing formula is derived by assuming that there exists a defaultable forward rate term structure and that firms in the economy interact when default occurs.Generally,The ...In this paper a generalized defaultable bond pricing formula is derived by assuming that there exists a defaultable forward rate term structure and that firms in the economy interact when default occurs.Generally,The risk-neutral default intensity λ Q is not equal to the empirical or actual default intensity λ.This paper proves that multiple default intensities are invariant under equivalent martingale transformation,given a well-diversified portfolio corresponding to the defaultable bond.Thus one can directly apply default intensities and fractional losses empirically estimated to the evaluation of defaultable bonds or contingent claims.展开更多
This paper analyzes the influence of downside risk on defaultable bond returns.By introducing a defaultable bond-trading model,we show that the decline in market risk tolerance and information accuracy leads to tradin...This paper analyzes the influence of downside risk on defaultable bond returns.By introducing a defaultable bond-trading model,we show that the decline in market risk tolerance and information accuracy leads to trading loss under downside conditions.Our empirical analysis indicates that downside risk can explain a large proportion of the variation in yield spreads and contains almost all valid information on liquidity risk.As the credit level decreases,the explanatory power of downside risk increases significantly.We also investigate the predictive power of downside risk in cross-sectional defaultable bond excess returns using a portfolio-level analysis and Fama-Mac Beth regressions.We find that downside risk is a strong and robust predictor for future bond returns.In addition,due to the higher proportion of abnormal transactions in the Chinese bond market,downside risk proxy semi-variance can better explain yield spreads and predict portfolio excess returns than the proxy value at risk.展开更多
This paper considers an improved model of pricing defaultable bonds under the assumption that the interest rate satisfies the Vasicek model driven by fractional Brownian motion(fBm for short)based on the counterparty ...This paper considers an improved model of pricing defaultable bonds under the assumption that the interest rate satisfies the Vasicek model driven by fractional Brownian motion(fBm for short)based on the counterparty risk framework of Jarrow and Yu(2001). The authors use the theory of stochastic analysis of f Bm to derive pricing formulas for the defaultable bonds and study how the counterparty risk, recovery rate, and the Hurst parameter affect the values of the defaultable bonds.Numerical experiment results are presented to demonstrate the findings.展开更多
This paper considers the estimation of an unknown function h that can be characterized as a solution to a nonlinear operator equation mapping between two infinite dimensional Hilbert spaces. The nonlinear operator is ...This paper considers the estimation of an unknown function h that can be characterized as a solution to a nonlinear operator equation mapping between two infinite dimensional Hilbert spaces. The nonlinear operator is unknown but can be consistently estimated, and its inverse is discontinuous, rendering the problem ill-posed. We establish the consistency for the class of estimators that are regularized using general lower semicompact penalty functions. We derive the optimal convergence rates of the estimators under the Hilbert scale norms. We apply our results to two important problems in economics and finance: (1) estimating the parameters of the pricing kernel of defaultable bonds; (2) recovering the volatility surface implied by option prices allowing for measurement error in the option prices and numerical error in the computation of the operator.展开更多
This study considers an optimal investment and reinsurance problem involving a defaultable security for an insurer in an ambiguous environment.In other words,the insurer is ambiguous about the insurance claim that is ...This study considers an optimal investment and reinsurance problem involving a defaultable security for an insurer in an ambiguous environment.In other words,the insurer is ambiguous about the insurance claim that is exponentially distributed with an uncertain rate parameter.The insurer can purchase proportional reinsurance and invest its wealth in three assets:a risk-free asset,a risky asset,the price process of which satisfies the Heston local-stochastic volatility model,and a defaultable corporate bond.For the optimal investment–reinsurance objective with a smooth ambiguity utility proposed by Klibanoff,P.,Marinacci,M.,and Mukerji,S.[A smooth model of decision making under ambiguity,Econometrica,2005,73(6):1849-1892],the equilibrium strategy is introduced and the extended Hamilton–Jacobi–Bellman equation is established through a stochastic control approach.However,the analytical solution of the strategy under the Heston local-stochastic volatility model cannot be obtained because of the complicated nonlinearity of the partial differential equation.In this study,we employ a perturbation method to derive an asymptotic solution for the post-and pre-default cases.In addition,we present a sensitivity analysis to explain the impact of model parameters on the equilibrium investment–reinsurance strategy.展开更多
This paper investigates the inverse problem of bi-revealed utilities in a defaultable universe,defined as a standard universe(represented by a filtration F)perturbed by an exogenous defaultable time τ.We assume that ...This paper investigates the inverse problem of bi-revealed utilities in a defaultable universe,defined as a standard universe(represented by a filtration F)perturbed by an exogenous defaultable time τ.We assume that the standard universe does not take into account the possibility of the default,thus τ adds an additional source of risk.The defaultable universe is represented by the filtration G up to time τ(τ included),where G stands for the progressive enlargement of F by T.The basic assumption in force is that τ avoids F-stopping times.The bi-revealed problem consists in recovering a consistent dynamic utility from the observable characteristic of an agent.The general results on bi-revealed utilities,first given in a general and abstract framework,are translated in the defaultable G-universe and then are interpreted in the F-universe.The decomposition of G-adapted processes X^(G) provides an interpretation of a Gcharacteristic X^(G)_(τ) stopped at τ as a reserve process.Thanks to the characterization of G-martingales stopped at τ in terms of F-martingales,we establish a correspondence between G-bi-revealed utilities from characteristic and F-bi-revealed pair of utilities from characteristic and reserves.In a financial framework,characteristic can be interpreted as wealth and reserves as consumption.This result sheds a new light on the consumption in utility criterion:the consumption process can be interpreted as a certain quantity of wealth,or reserves,that are accumulated for the financing of losses at the default time.展开更多
Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the u...Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.展开更多
Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation(iTBS)and hinders the identification of predictive factors.This study investigated functional network con...Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation(iTBS)and hinders the identification of predictive factors.This study investigated functional network connectivity and predictors of iTBS treatment outcomes in adolescents and young adults with depression.Aim This study aimed to identify default mode network(DMN)-based connectivity patterns associated with varying iTBS treatment outcomes in depression.Methods Data from a randomised controlled trial of iTBS in depression(n=82)were analysed using a data-driven approach to classify homogeneous subgroups based on the DMN.Connectivity subgroups were compared on depressive symptoms and cognitive function at pretreatment and post-treatment.Furthermore,the predictive significance of baseline inflammatory cytokines on post-treatment outcomes was evaluated.Results Two distinct subgroups were identified.Subgroup 1 exhibited high heterogeneity and greater centrality in the posterior cingulate cortex and retrosplenial cortex,while subgroup 2 showed more homogeneous connectivity patterns and greater centrality in the temporoparietal junction and posterior inferior parietal lobule.No main effect for subgroup,treatment or subgroup×treatment interaction was revealed in the improvement of depressive symptoms.A significant subgroup×treatment interaction related to symbol coding improvement was detected(F=5.22,p=0.026).Within subgroup 1,the active group showed significantly greater improvement in symbol coding compared with the sham group(t=2.30,p=0.028),while baseline levels of interleukin-6 and C-reactive protein emerged as significant indicators for predicting improvements in symbolic coding(R2=0.35,RMSE(root-mean-square error)=5.72,p=0.013).Subgroup 2 showed no significant findings in terms of cognitive improvement or inflammatory cytokines predictions.展开更多
BACKGROUND Currently,adolescent depression is one of the most significant public health concerns,markedly influencing emotional,cognitive,and social maturation.Despite advancements in distinguish the neurobiological s...BACKGROUND Currently,adolescent depression is one of the most significant public health concerns,markedly influencing emotional,cognitive,and social maturation.Despite advancements in distinguish the neurobiological substrates underlying depression,the intricate patterns of disrupted brain network connectivity in adolescents warrant further exploration.AIM To elucidate the neural correlates of adolescent depression by examining brain network connectivity using resting-state functional magnetic resonance imaging(rs-fMRI).METHODS The study cohort comprised 74 depressed adolescents and 59 healthy controls aged 12 to 17 years.Participants underwent rs-fMRI to evaluate functional connectivity within and across critical brain networks,including the visual,default mode network(DMN),dorsal attention,salience,somatomotor,and frontoparietal control networks.RESULTS Analyses revealed pronounced functional disparities within key neural circuits among adolescents with depression.The results demonstrated existence of hemispheric asymmetries characterized by enhanced activity in the left visual network,which contrasted the diminished activity in the right hemisphere.The DMN facilitated increased activity within the left prefrontal cortex and reduced engagement in the right hemisphere,implicating disrupted self-referential and emotional processing mechanisms.Additionally,an overactive right dorsal attention network and a hypoactive salience network were identified,underscoring significant abnormalities in attentional and emotional regulation in adolescent depression.CONCLUSION The findings from this study underscore distinct neural connectivity disruptions in adolescent depression,underscoring the critical role of specific neurobiological markers for precise early diagnosis of adolescent depression.The observed functional asymmetries and network-specific deviations elucidate the complex neurobiological architecture of adolescent depression,supporting the development of targeted therapeutic strategies.展开更多
BACKGROUND Group cognitive behavioral therapy(GCBT)is increasingly being used to treat obsessive-compulsive disorder(OCD)because of its high efficiency,economy,and interaction among group members.However,the changes i...BACKGROUND Group cognitive behavioral therapy(GCBT)is increasingly being used to treat obsessive-compulsive disorder(OCD)because of its high efficiency,economy,and interaction among group members.However,the changes in network functional connectivity(FC)in patients with OCD with GCBT remain unclear.AIM To investigate inter-and intra-network resting-state FC(rs-FC)abnormalities before and after GCBT in unmedicated patients with OCD and validate the efficacy of GCBT.METHODS Overall,33 individuals with OCD and 26 healthy controls underwent resting-state functional magnetic resonance imaging.The patients were rescanned 12 weeks after GCBT.Four cognition-related networks-default mode network(DMN),dorsal attention network(DAN),salience network(SAN),and frontoparietal network(FPN)-were selected to examine FC abnormalities within and between OCD networks before and after GCBT.Neuropsychological assessments including memory,executive function,speech,attention,and visuospatial ability were reassessed following GCBT.Pearson’s correlations were used to analyze the relationship between aberrant FC in cognition-related networks and altered neuropsychological assessments in patients.RESULTS Rs-FC within the DMN and DAN decreased significantly.Additionally,rs-FC between the DMN-DAN,DMNFPN,DMN-SAN,and DAN-SAN also decreased.Significant improvements were observed in cognitive functions,such as memory,executive function,attention,and visuospatial ability.Furthermore,reduced rs-FC within the DMN correlated with visuospatial ability and executive function;DAN positively correlated with Shape Trails Test(STT)-A test elapsed time;DMN-DAN negatively correlated with Rey-Osterrieth Complex Figure(Rey-O)mimicry time and the three elapsed times of the tower of Hanoi;DMN-SAN negatively correlated with Rey-O imitation time and positively correlated with STT-A test elapsed time;and DMN-FPN negatively correlated with Auditory Word Learning Test N1 and N4 scores.CONCLUSION Decreased rs-FC within the DMN and DAN,which correlated with executive function post-treatment,has potential as a neuroimaging marker to predict treatment response to GCBT in patients with OCD.展开更多
This study investigates the determinants that drive the volatility of the credit default swaps(CDS)of BRICIT(Brazil,Russia,India,China,Indonesia,and Turkey)nations as a proxy measure for sovereign risk.On the existenc...This study investigates the determinants that drive the volatility of the credit default swaps(CDS)of BRICIT(Brazil,Russia,India,China,Indonesia,and Turkey)nations as a proxy measure for sovereign risk.On the existence of cointegration,an unrestricted error correction model integrated with the autoregressive distributed lag(ARDL)model is applied to measure the short-run and long-run dynamics empirically.The study utilizes the Bayesian global vector autoregression methodology for cross-border spillover estimation.The study also suggests a strategy for policymakers for quadrant categorization to mitigate risk arising from cross-border spillover.The result of ARDL indicates that the global macroeconomic variables affect the BRICIT CDS more than domestic macroeconomic determinants,with Indian CDS being the most sensitive to Fed tapering.Notably,China’s CDS is the most sensitive to shocks,with the CDS volatility primarily driven by China’s geopolitical risk.Russian CDS is more sensitive to real effective exchange rates due to severe ruble depreciation than crude oil,despite Russia being a major oil exporter.The quadrant categorization indicates that the Indonesian stock market index is most interconnected with BRICIT CDS,while the Turkish long-term interest rates send the highest intensity spillover across BRICIT nations.展开更多
presented The conceptions of abstract default reasoning frameworks （ADRFs） and D-consequence relations are Based on representation properties of D-consequence relations, it proves that any cumulative nonmonotonic co...presented The conceptions of abstract default reasoning frameworks （ADRFs） and D-consequence relations are Based on representation properties of D-consequence relations, it proves that any cumulative nonmonotonic consequence relation with the connective-free form can be represented by ADRFs.展开更多
In the relevance-theoretic framework,translation is an act of communication carried out between two cultures through the medium of language,which involves the cognition of three parts;the original writer,the translato...In the relevance-theoretic framework,translation is an act of communication carried out between two cultures through the medium of language,which involves the cognition of three parts;the original writer,the translator,and the target reader.Since it is a culture-specific phenomenon and the cognitive environment of the original writer and the target reader are different,cultural default often results in misreading or incoherent understanding in cross-cultural communication.展开更多
Schizophrenia is a severe mental disorder characterized by impaired perception, delusions, thought disorder, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network （DMN）, s...Schizophrenia is a severe mental disorder characterized by impaired perception, delusions, thought disorder, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network （DMN）, since it was first proposed in 2001, has become a central research theme in neuropsychiatric disorders, including schizophrenia. In this review, first we define the DMN and describe its functional activity, functional and anatomical connectivity, heritability, and inverse correlation with the task positive network. Second, we review empirical studies of the anatomical and functional DMN, and anti-correlation between DMN and the task positive network in schizophrenia. Finally, we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN, review the role of DMN as a treatment biomarker for this disease, and consider the DMN effects of individualized therapies for schizophrenia.展开更多
Mood disorders/psychosis have been associated with dysfunctions in the default mode network(DMN).However,the relative contributions of DMN regions to state and trait disturbances in pediatric bipolar disorder(PBD)rema...Mood disorders/psychosis have been associated with dysfunctions in the default mode network(DMN).However,the relative contributions of DMN regions to state and trait disturbances in pediatric bipolar disorder(PBD)remain unclear.The aim of this study was to investigate the possible mechanisms of PBD through brain imaging and explore the influence of psychotic symptoms on functional alterations in PBD patients.Twenty-nine psychotic and 26 non-psychotic PBD patients,as well as 19 age-and sex-matched healthy controls underwent a restingstate functional MRI scan and the data were analyzed by independent component analysis.The DMN component from the fMRI data was extracted for each participant.Spearman's rank correlation analysis was performed between aberrant connectivity and clinical measurements.The results demonstrated that psychotic PBD was characterized by aberrant DMN connectivity in the anterior cingulate cortex/medial prefrontal cortex,bilateral caudate nucleus,bilateral angular gyri,and left middle temporal gyrus,while non-psychotic PBD was not,suggesting further impairment with the development of psychosis.In summary,we demonstrated unique impairment in DMN functional connectivity in the psychotic PBD group.These specific neuroanatomical abnormalities may shed light on the underlying pathophysiology and presentation of PBD.展开更多
基金National Natural Science Foundation of China(70 0 71 0 1 2 )
文摘In this paper a generalized defaultable bond pricing formula is derived by assuming that there exists a defaultable forward rate term structure and that firms in the economy interact when default occurs.Generally,The risk-neutral default intensity λ Q is not equal to the empirical or actual default intensity λ.This paper proves that multiple default intensities are invariant under equivalent martingale transformation,given a well-diversified portfolio corresponding to the defaultable bond.Thus one can directly apply default intensities and fractional losses empirically estimated to the evaluation of defaultable bonds or contingent claims.
基金supported by the National Natural Science Foundation of China under Grant No.71471129,71501140
文摘This paper analyzes the influence of downside risk on defaultable bond returns.By introducing a defaultable bond-trading model,we show that the decline in market risk tolerance and information accuracy leads to trading loss under downside conditions.Our empirical analysis indicates that downside risk can explain a large proportion of the variation in yield spreads and contains almost all valid information on liquidity risk.As the credit level decreases,the explanatory power of downside risk increases significantly.We also investigate the predictive power of downside risk in cross-sectional defaultable bond excess returns using a portfolio-level analysis and Fama-Mac Beth regressions.We find that downside risk is a strong and robust predictor for future bond returns.In addition,due to the higher proportion of abnormal transactions in the Chinese bond market,downside risk proxy semi-variance can better explain yield spreads and predict portfolio excess returns than the proxy value at risk.
基金supported by the National Natural Science Foundation of China under Grant Nos.11471051 and 11871010supported by the National Social Science Foundation of China under Grant No.16ZDA033
文摘This paper considers an improved model of pricing defaultable bonds under the assumption that the interest rate satisfies the Vasicek model driven by fractional Brownian motion(fBm for short)based on the counterparty risk framework of Jarrow and Yu(2001). The authors use the theory of stochastic analysis of f Bm to derive pricing formulas for the defaultable bonds and study how the counterparty risk, recovery rate, and the Hurst parameter affect the values of the defaultable bonds.Numerical experiment results are presented to demonstrate the findings.
基金supported by US National Science Foundation (Grant No. SES-0631613)the Cowles Foundation for Research in Economics
文摘This paper considers the estimation of an unknown function h that can be characterized as a solution to a nonlinear operator equation mapping between two infinite dimensional Hilbert spaces. The nonlinear operator is unknown but can be consistently estimated, and its inverse is discontinuous, rendering the problem ill-posed. We establish the consistency for the class of estimators that are regularized using general lower semicompact penalty functions. We derive the optimal convergence rates of the estimators under the Hilbert scale norms. We apply our results to two important problems in economics and finance: (1) estimating the parameters of the pricing kernel of defaultable bonds; (2) recovering the volatility surface implied by option prices allowing for measurement error in the option prices and numerical error in the computation of the operator.
基金isupported by the National Natural Science Foundation of China(Grant Nos.11871010 and 11971040)the Fundamental Research Funds for the Central Universities(Grant No.2019XD-A11)The work of Weilin Xiao is supported by the Humanities and Social Sciences of Ministry of Education Planning Fund of China(Grant No.23YJA630102).
文摘This study considers an optimal investment and reinsurance problem involving a defaultable security for an insurer in an ambiguous environment.In other words,the insurer is ambiguous about the insurance claim that is exponentially distributed with an uncertain rate parameter.The insurer can purchase proportional reinsurance and invest its wealth in three assets:a risk-free asset,a risky asset,the price process of which satisfies the Heston local-stochastic volatility model,and a defaultable corporate bond.For the optimal investment–reinsurance objective with a smooth ambiguity utility proposed by Klibanoff,P.,Marinacci,M.,and Mukerji,S.[A smooth model of decision making under ambiguity,Econometrica,2005,73(6):1849-1892],the equilibrium strategy is introduced and the extended Hamilton–Jacobi–Bellman equation is established through a stochastic control approach.However,the analytical solution of the strategy under the Heston local-stochastic volatility model cannot be obtained because of the complicated nonlinearity of the partial differential equation.In this study,we employ a perturbation method to derive an asymptotic solution for the post-and pre-default cases.In addition,we present a sensitivity analysis to explain the impact of model parameters on the equilibrium investment–reinsurance strategy.
基金This work is with the financial support of the“Chaire Risque Financier”of the“Fondation du Risque”,the Labex MME-DII.The authors's research is part of the ANR project DREAMeS(ANR-21-CE46-0002).
文摘This paper investigates the inverse problem of bi-revealed utilities in a defaultable universe,defined as a standard universe(represented by a filtration F)perturbed by an exogenous defaultable time τ.We assume that the standard universe does not take into account the possibility of the default,thus τ adds an additional source of risk.The defaultable universe is represented by the filtration G up to time τ(τ included),where G stands for the progressive enlargement of F by T.The basic assumption in force is that τ avoids F-stopping times.The bi-revealed problem consists in recovering a consistent dynamic utility from the observable characteristic of an agent.The general results on bi-revealed utilities,first given in a general and abstract framework,are translated in the defaultable G-universe and then are interpreted in the F-universe.The decomposition of G-adapted processes X^(G) provides an interpretation of a Gcharacteristic X^(G)_(τ) stopped at τ as a reserve process.Thanks to the characterization of G-martingales stopped at τ in terms of F-martingales,we establish a correspondence between G-bi-revealed utilities from characteristic and F-bi-revealed pair of utilities from characteristic and reserves.In a financial framework,characteristic can be interpreted as wealth and reserves as consumption.This result sheds a new light on the consumption in utility criterion:the consumption process can be interpreted as a certain quantity of wealth,or reserves,that are accumulated for the financing of losses at the default time.
文摘Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.
基金supported by the Guangzhou Municipal Key Discipline in Medicine(2021-2023)the Guangzhou High-level Clinical Key Specialty,the Guangzhou Research-oriented Hospital,the Innovative Clinical Technique of Guangzhou(2024-2026)+6 种基金the Guangdong Basic and Applied Basic Research Foundation(grant number 2022A1515011567,2020A1515110565)the Guangzhou Science,Technology Planning Project(grant number 202201010714,202103000032)the National Natural Science Foundation of China(grant number 82471546)the Guangdong College Students Innovation and Entrepreneurship Training Project(grant number S202310570038)the Guangzhou Health Science and Technology Project(grant number 20231A010038)the Guangzhou Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine Technology Project(grant number:20232A010013)the Science and Technology Plan Project of Guangzhou(2023A03J0842).
文摘Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation(iTBS)and hinders the identification of predictive factors.This study investigated functional network connectivity and predictors of iTBS treatment outcomes in adolescents and young adults with depression.Aim This study aimed to identify default mode network(DMN)-based connectivity patterns associated with varying iTBS treatment outcomes in depression.Methods Data from a randomised controlled trial of iTBS in depression(n=82)were analysed using a data-driven approach to classify homogeneous subgroups based on the DMN.Connectivity subgroups were compared on depressive symptoms and cognitive function at pretreatment and post-treatment.Furthermore,the predictive significance of baseline inflammatory cytokines on post-treatment outcomes was evaluated.Results Two distinct subgroups were identified.Subgroup 1 exhibited high heterogeneity and greater centrality in the posterior cingulate cortex and retrosplenial cortex,while subgroup 2 showed more homogeneous connectivity patterns and greater centrality in the temporoparietal junction and posterior inferior parietal lobule.No main effect for subgroup,treatment or subgroup×treatment interaction was revealed in the improvement of depressive symptoms.A significant subgroup×treatment interaction related to symbol coding improvement was detected(F=5.22,p=0.026).Within subgroup 1,the active group showed significantly greater improvement in symbol coding compared with the sham group(t=2.30,p=0.028),while baseline levels of interleukin-6 and C-reactive protein emerged as significant indicators for predicting improvements in symbolic coding(R2=0.35,RMSE(root-mean-square error)=5.72,p=0.013).Subgroup 2 showed no significant findings in terms of cognitive improvement or inflammatory cytokines predictions.
基金Supported by the Medical Research Project of the Chongqing Municipal Health Commission,No.2024WSJK110.
文摘BACKGROUND Currently,adolescent depression is one of the most significant public health concerns,markedly influencing emotional,cognitive,and social maturation.Despite advancements in distinguish the neurobiological substrates underlying depression,the intricate patterns of disrupted brain network connectivity in adolescents warrant further exploration.AIM To elucidate the neural correlates of adolescent depression by examining brain network connectivity using resting-state functional magnetic resonance imaging(rs-fMRI).METHODS The study cohort comprised 74 depressed adolescents and 59 healthy controls aged 12 to 17 years.Participants underwent rs-fMRI to evaluate functional connectivity within and across critical brain networks,including the visual,default mode network(DMN),dorsal attention,salience,somatomotor,and frontoparietal control networks.RESULTS Analyses revealed pronounced functional disparities within key neural circuits among adolescents with depression.The results demonstrated existence of hemispheric asymmetries characterized by enhanced activity in the left visual network,which contrasted the diminished activity in the right hemisphere.The DMN facilitated increased activity within the left prefrontal cortex and reduced engagement in the right hemisphere,implicating disrupted self-referential and emotional processing mechanisms.Additionally,an overactive right dorsal attention network and a hypoactive salience network were identified,underscoring significant abnormalities in attentional and emotional regulation in adolescent depression.CONCLUSION The findings from this study underscore distinct neural connectivity disruptions in adolescent depression,underscoring the critical role of specific neurobiological markers for precise early diagnosis of adolescent depression.The observed functional asymmetries and network-specific deviations elucidate the complex neurobiological architecture of adolescent depression,supporting the development of targeted therapeutic strategies.
基金Supported by the Pharmaceutical Science and Technology Project of Zhejiang Province,No.2023RC266the Natural Science Foundation of Ningbo,No.202003N4266.
文摘BACKGROUND Group cognitive behavioral therapy(GCBT)is increasingly being used to treat obsessive-compulsive disorder(OCD)because of its high efficiency,economy,and interaction among group members.However,the changes in network functional connectivity(FC)in patients with OCD with GCBT remain unclear.AIM To investigate inter-and intra-network resting-state FC(rs-FC)abnormalities before and after GCBT in unmedicated patients with OCD and validate the efficacy of GCBT.METHODS Overall,33 individuals with OCD and 26 healthy controls underwent resting-state functional magnetic resonance imaging.The patients were rescanned 12 weeks after GCBT.Four cognition-related networks-default mode network(DMN),dorsal attention network(DAN),salience network(SAN),and frontoparietal network(FPN)-were selected to examine FC abnormalities within and between OCD networks before and after GCBT.Neuropsychological assessments including memory,executive function,speech,attention,and visuospatial ability were reassessed following GCBT.Pearson’s correlations were used to analyze the relationship between aberrant FC in cognition-related networks and altered neuropsychological assessments in patients.RESULTS Rs-FC within the DMN and DAN decreased significantly.Additionally,rs-FC between the DMN-DAN,DMNFPN,DMN-SAN,and DAN-SAN also decreased.Significant improvements were observed in cognitive functions,such as memory,executive function,attention,and visuospatial ability.Furthermore,reduced rs-FC within the DMN correlated with visuospatial ability and executive function;DAN positively correlated with Shape Trails Test(STT)-A test elapsed time;DMN-DAN negatively correlated with Rey-Osterrieth Complex Figure(Rey-O)mimicry time and the three elapsed times of the tower of Hanoi;DMN-SAN negatively correlated with Rey-O imitation time and positively correlated with STT-A test elapsed time;and DMN-FPN negatively correlated with Auditory Word Learning Test N1 and N4 scores.CONCLUSION Decreased rs-FC within the DMN and DAN,which correlated with executive function post-treatment,has potential as a neuroimaging marker to predict treatment response to GCBT in patients with OCD.
文摘This study investigates the determinants that drive the volatility of the credit default swaps(CDS)of BRICIT(Brazil,Russia,India,China,Indonesia,and Turkey)nations as a proxy measure for sovereign risk.On the existence of cointegration,an unrestricted error correction model integrated with the autoregressive distributed lag(ARDL)model is applied to measure the short-run and long-run dynamics empirically.The study utilizes the Bayesian global vector autoregression methodology for cross-border spillover estimation.The study also suggests a strategy for policymakers for quadrant categorization to mitigate risk arising from cross-border spillover.The result of ARDL indicates that the global macroeconomic variables affect the BRICIT CDS more than domestic macroeconomic determinants,with Indian CDS being the most sensitive to Fed tapering.Notably,China’s CDS is the most sensitive to shocks,with the CDS volatility primarily driven by China’s geopolitical risk.Russian CDS is more sensitive to real effective exchange rates due to severe ruble depreciation than crude oil,despite Russia being a major oil exporter.The quadrant categorization indicates that the Indonesian stock market index is most interconnected with BRICIT CDS,while the Turkish long-term interest rates send the highest intensity spillover across BRICIT nations.
文摘presented The conceptions of abstract default reasoning frameworks （ADRFs） and D-consequence relations are Based on representation properties of D-consequence relations, it proves that any cumulative nonmonotonic consequence relation with the connective-free form can be represented by ADRFs.
文摘In the relevance-theoretic framework,translation is an act of communication carried out between two cultures through the medium of language,which involves the cognition of three parts;the original writer,the translator,and the target reader.Since it is a culture-specific phenomenon and the cognitive environment of the original writer and the target reader are different,cultural default often results in misreading or incoherent understanding in cross-cultural communication.
基金supported by the National Natural Science Foundation of China(81271484,81471361,30900486,and 81371480)the National Basic Research Development Program(973 Program)of China(2012CB517904)the Nation Sponsored Study Abroad Program from China Scholarship Council(201506370095)
文摘Schizophrenia is a severe mental disorder characterized by impaired perception, delusions, thought disorder, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network （DMN）, since it was first proposed in 2001, has become a central research theme in neuropsychiatric disorders, including schizophrenia. In this review, first we define the DMN and describe its functional activity, functional and anatomical connectivity, heritability, and inverse correlation with the task positive network. Second, we review empirical studies of the anatomical and functional DMN, and anti-correlation between DMN and the task positive network in schizophrenia. Finally, we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN, review the role of DMN as a treatment biomarker for this disease, and consider the DMN effects of individualized therapies for schizophrenia.
基金supported by National Natural Science Foundation of China (81171291, 81371531, 81571344, 81871344)the Natural Science Foundation of Jiangsu Province, China (BK20161109)+2 种基金the Key Program for Guangming Lu (BWS11J063, and 10z026)the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province, China (18KJB190003)the Postdoctoral Science Foundation of China (2014M552700)
文摘Mood disorders/psychosis have been associated with dysfunctions in the default mode network(DMN).However,the relative contributions of DMN regions to state and trait disturbances in pediatric bipolar disorder(PBD)remain unclear.The aim of this study was to investigate the possible mechanisms of PBD through brain imaging and explore the influence of psychotic symptoms on functional alterations in PBD patients.Twenty-nine psychotic and 26 non-psychotic PBD patients,as well as 19 age-and sex-matched healthy controls underwent a restingstate functional MRI scan and the data were analyzed by independent component analysis.The DMN component from the fMRI data was extracted for each participant.Spearman's rank correlation analysis was performed between aberrant connectivity and clinical measurements.The results demonstrated that psychotic PBD was characterized by aberrant DMN connectivity in the anterior cingulate cortex/medial prefrontal cortex,bilateral caudate nucleus,bilateral angular gyri,and left middle temporal gyrus,while non-psychotic PBD was not,suggesting further impairment with the development of psychosis.In summary,we demonstrated unique impairment in DMN functional connectivity in the psychotic PBD group.These specific neuroanatomical abnormalities may shed light on the underlying pathophysiology and presentation of PBD.
