The efficacy of photodynamic therapy(PDT)for breast tumors is hindered by challenges such as inadequate tumor targeting,limited treatment depth,and strong oxygen dependence.Herein,a promising photosensitizer VP-B was ...The efficacy of photodynamic therapy(PDT)for breast tumors is hindered by challenges such as inadequate tumor targeting,limited treatment depth,and strong oxygen dependence.Herein,a promising photosensitizer VP-B was developed to simultaneously address all the aforementioned issues for the treatment of hypoxic deep-seated breast tumors.The biotinylated photosensitizer VP-B not only exhibited precise targeting towards breast tumor tissue,but also efficiently triggered the generation of abundant1O2and O2-·under 690 nm red light irradiation.Indeed,the red light penetration ability enabled VP-B to achieve successful application in a mouse orthotopic breast tumor model.After intravenous administration,VP-B can selectively target tumor tissues and significantly inhibit the growth of hypoxic deep-seated tumors.Therefore,this new typeⅠ&Ⅱphotosensitizer could boost fluorescence-guided photodynamic therapy of other hypoxic solid tumors.展开更多
Extensive urban areas worldwide face significant landslide hazards, impacting inhabitants, buildings, and critical infrastructures alike. In the case of slow-moving deep-seated landslides involving huge areas and char...Extensive urban areas worldwide face significant landslide hazards, impacting inhabitants, buildings, and critical infrastructures alike. In the case of slow-moving deep-seated landslides involving huge areas and characterized by complex patterns, when the cost of repairing infrastructures, relocating communities, and restoring cultural sites might be such that it is unsustainable for the community, the exposed structures require significant effort for their surveillance and protection, which can be supported by the development of innovative monitoring systems. For this purpose, a smart extenso-inclinometer, realized by equipping a conventional inclinometer tube with distributed strain and temperature transducers based on optical fiber sensing technology, is presented. In situ monitoring of the active deep-seated San Nicola landslide in Centola (Campania, southern Italy) demonstrated its ability to capture the main features of movements and reconstruct a tridimensional evolution of the landslide pattern, even when the entity of both vertical and horizontal soil strain components is comparable. Although further tests are needed to definitively ascertain the extensometer function of the new device, by interpreting the strain profiles of the landslide body and identifying the achievement of predetermined thresholds, this system could provide a warning of the trigger of a landslide event. The use of the smart extenso-inclinometer within an early warning system for slow-moving landslides holds immense potential for reducing the impact of landslide events.展开更多
Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electro...Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electrocatalytic reaction kinetics at the cathode.The integration of light energy into Zn/Sn-air batteries is a promising strategy for enhancing their performance.However,the photothermal and photoelectric effects generate heat in the battery under prolonged solar irradiation,leading to air cathode instability.This paper presents the first design and synthesis of Ni_(2)-1,5-diamino-4,8-dihydroxyanthraquinone(Ni_(2)DDA),an electronically conductiveπ-d conjugated metal-organic framework(MOF).Ni_(2)DDA exhibits both photoelectric and photothermal effects,with an optical band gap of~1.14 eV.Under illumination,Ni_(2)DDA achieves excellent oxygen evolution reaction performance(with an overpotential of 245 mV vs.reversible hydrogen electrode at 10 mA cm^(−2))and photothermal stability.These properties result from the synergy between the photoelectric and photothermal effects of Ni_(2)DDA.Upon integration into Zn/Sn-air batteries,Ni_(2)DDA ensures excellent cycling stability under light and exhibits remarkable performance in high-temperature environments up to 80℃.This study experimentally confirms the stable operation of photo-assisted Zn/Sn-air batteries under high-temperature conditions for the first time and provides novel insights into the application of electronically conductive MOFs in photoelectrocatalysis and photothermal catalysis.展开更多
Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based met...Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.展开更多
Benzalkonium chloride(BAC)is widely employed as a broad-spectrum biocide and has emerged as a significant environmental pollutant.Polymyxin B(PB)serves as the last-line defense for the treatment of Gram-negative patho...Benzalkonium chloride(BAC)is widely employed as a broad-spectrum biocide and has emerged as a significant environmental pollutant.Polymyxin B(PB)serves as the last-line defense for the treatment of Gram-negative pathogens.Previous studies reported that BAC-adapted Pseudomonas aeruginosa increased the tolerance to PB.Herein,we present the novel finding that the combination of BAC and PB exhibited synergistic antibacterial effects against P.aeruginosa.Time-killing assay demonstrated a significant reduction in bacterial cell viability.Scanning electron microscopy,zeta potential analysis,hydrophobicity measurements,and fluorescence probe analyses collectively revealed severe disruption of the cell envelope and membrane potential induced by the combination of BAC and PB.Transcriptomic analysis revealed that the BAC-PB combination notably downreg-ulated the expression of genes involved in lipid A modification and cell envelope production,including phoPQ,pmrAB,bamABCDE,lptABCDEG,lolB,yidC,and murJ.Additionally,the combination group exhibited augmented production of reactive oxygen species and diminished ATP synthesis.The expression of the genes associated with substance metabolism and energy generation was significantly impeded.This study provides significant implica-tions for the interactions of biocides and antibiotics on Gram-negative pathogens,while also addressing antibiotic resistance and developing the external treatment strategy for Pseudomonas-infected wounds and burns.展开更多
AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 group...AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.展开更多
Electrical and electronic devices face significant challenges in heatmanagement due to their compact size and high heat flux,which negatively impact performance and reliability.Conventional coolingmethods,such as forc...Electrical and electronic devices face significant challenges in heatmanagement due to their compact size and high heat flux,which negatively impact performance and reliability.Conventional coolingmethods,such as forced air cooling,often struggle to transfer heat efficiently.In contrast,thermoelectric coolers(TECs)provide an innovative active cooling solution to meet growing thermal management demands.In this research,a refrigerant based on mono ethylene glycol and distilled water was used instead of using gases,in addition to using thermoelectric cooling units instead of using a compressor in traditional refrigeration systems.This study evaluates the performance of a Peltierbased thermalmanagement systemby analyzing the effects of using two,three,and four Peltiermodules on cooling rates,power consumption,temperature reduction,and system efficiency.Experimental results indicate that increasing the number of Peltier modules significantly enhances cooling performance.The four-module system achieved an optimal balance between cooling speed and energy efficiency,reducing the temperature of a liquidmixture(30% mono ethylene glycol+70% distilled water plus laser dyes)to 8℃ in just 17 min.It demonstrated a cooling rate of 0.794℃/min and a high coefficient of performance(COP)of 1.2 while consuming less energy than the two-and three-module systems.Furthermore,the study revealed that increasing the number of modules led to faster air cooling and improved temperature reduction.These findings highlight the importance of selecting the optimal number of Peltier modules to enhance efficiency and cooling speed whileminimizing energy consumption.This makes TEC technology a sustainable and effective solution for applications requiring rapid and reliable thermal management.展开更多
The magnetic properties and Kondo effect in Ce3TiBi5 with a quasi-one-dimensional structure were investigated using in situ high-pressure resistivity measurements up to 48 GPa.At ambient pressure,Ce_(3)TiBi_(5) underg...The magnetic properties and Kondo effect in Ce3TiBi5 with a quasi-one-dimensional structure were investigated using in situ high-pressure resistivity measurements up to 48 GPa.At ambient pressure,Ce_(3)TiBi_(5) undergoes an antiferromagnetic(AFM)transition at T_(N)∼5 K.Under high pressures within 8.9 GPa,we find that Kondo scattering contributes differently to the high-temperature resistance,R(T),depending on the applied current direction,demonstrating a significantly anisotropic Kondo effect.The complete P–T phase diagram has been constructed,in which the pressure dependence of T_(N) exhibits a dome-like shape.The AFM order remains robust under pressure,even when the coherence temperature T^(*) far exceeds 300 K.We attribute the observed anisotropic Kondo effect and the robust AFM to the underlying anisotropy in electronic hybridization under high pressure.展开更多
In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural a...In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural and anthropogenic effects on marine aerosols optical properties,as well as the applicability of multi-satellite products and IMPROVE equation.The averaged aerosol optical depth(AOD500 nm)was 0.31±0.16 andÅngström exponent440–675 nm was 0.29±0.30.In offshore China,significant anthropogenic emissions affected the marine environment.In remote WPO,dust aerosols transported from northern China,Siberia,Central Asia,and those settling from the upper troposphere originating from north Africa,Arabian peninsula,and western India,were dominant.The spatial trends of AOD were opposite in the mid-latitude and southern seas of WPO.The highest AOD,0.32±0.23,appeared along the coast of South Asia at mid-latitude,decreasing from offshore seas to remote oceans.In low-latitude and equatorial seas,AOD significantly increased from coast to remote oceans.Ångström exponent dropped significantly from the coast to remote oceans as anthropogenic influence diminished across the entire WPO.Correlation analysis showed that both MODIS-C6 and Himawari AOD prod-ucts showed similar applicability in coastal urban areas,while Himawari AOD is highly recommended for coastal background and marine environment due to its finer resolution.The extinction coefficient derived from PM_(2.5) chemical compositions using IMPROVE algorithm exhibited a significant correlation(R^(2)=0.58)with the con-currently measured AOD in the absence of long-distance transport,suggesting that the IMPROVE is a reasonable proxy of the columnar average of marine aerosol extinctions free from transport influences.展开更多
This paper prepared a novel as-cast W-Zr-Ti metallic ESM using high-frequency vacuum induction melting technique.The above ESM performs a typical elastic-brittle material feature and strain rate strengthening behavior...This paper prepared a novel as-cast W-Zr-Ti metallic ESM using high-frequency vacuum induction melting technique.The above ESM performs a typical elastic-brittle material feature and strain rate strengthening behavior.The specimens exhibit violent chemical reaction during the fracture process under the impact loading,and the size distribution of their residual debris follows Rosin-Rammler model.The dynamic fracture toughness is obtained by the fitting of debris length scale,approximately 1.87 MPa·m~(1/2).Microstructure observation on residual debris indicates that the failure process is determined by primary crack propagation under quasi-static compression,while it is affected by multiple cracks propagation in both particle and matrix in the case of dynamic impact.Impact test demonstrates that the novel energetic fragment performs brilliant penetration and combustion effect behind the front target,leading to the effective ignition of fuel tank.For the brittleness of as-cast W-ZrTi ESM,further study conducted bond-based peridynamic(BB-PD)C++computational code to simulate its fracture behavior during penetration.The BB-PD method successfully captured the fracture process and debris cloud formation of the energetic fragment.This paper explores a novel as-cast metallic ESM,and provides an available numerical avenue to the simulation of brittle energetic fragment.展开更多
Background:While the treatment of metastatic renal cell carcinoma(mRCC)is evolving due to immune checkpoint inhibitors(ICIs),optimal strategies for later lines of therapy have yet to be defined.The combination of lenv...Background:While the treatment of metastatic renal cell carcinoma(mRCC)is evolving due to immune checkpoint inhibitors(ICIs),optimal strategies for later lines of therapy have yet to be defined.The combination of lenvatinib and everolimus represents a viable option,and the present review aimed to summarize its activity,effectiveness,and safety.Methods:A systematic review of the literature was conducted using PubMed,targeting studies published between 2018 and 2025.Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen.Results:Nine studies met the inclusion criteria,encompassing a total of 441 patients.The lenvatinib and everolimus combination was primarily used in the third and subsequent lines of therapy.Median overall survival ranged from 7.5 to 24.5 months,while median progression-free survival was more consistent,between 6.1 and 6.7 months,except for one study reporting 12.9 months.Objective response rates varied widely(14.0%–55.7%).Adverse events of grade≥3 did not exceed the expected rate,with diarrhoea and proteinuria as the most reported events.Dose reductions and treatment discontinuations due to toxicity occurred but were generally lower than in prior pivotal trials.Conclusions:Real-world evidence suggests that lenvatinib and everolimus represent an effective and safe option after ICI failure in mRCC patients.Nevertheless,the lack of randomized phase III trials and the heterogeneity of existing studies highlight the need for more robust prospective research to guide post-ICI therapeutic strategies.展开更多
Lithium metal batteries(LMBs)have been regarded as one of the most promising alternatives in the post-lithium battery era due to their high energy density,which meets the needs of light-weight electronic devices and l...Lithium metal batteries(LMBs)have been regarded as one of the most promising alternatives in the post-lithium battery era due to their high energy density,which meets the needs of light-weight electronic devices and long-range electric vehicles.However,technical barriers such as dendrite growth and poor Li plating/stripping reversibility severely hinder the practical application of LMBs.However,lithium nitrate(LiNO_(3))is found to be able to stabilize the Li/electrolyte interface and has been used to address the above challenges.To date,considerable research efforts have been devoted toward understanding the roles of LiNO_(3) in regulating the surface properties of Li anodes and toward the development of many effective strategies.These research efforts are partially mentioned in some articles on LMBs and yet have not been reviewed systematically.To fill this gap,we discuss the recent advances in fundamental and technological research on LiNO_(3) and its derivatives for improving the performances of LMBs,particularly for Li-sulfur(S),Li-oxygen(O),and Li-Li-containing transition-metal oxide(LTMO)batteries,as well as LiNO_(3)-containing recipes for precursors in battery materials and interphase fabrication.This review pays attention to the effects of LiNO_(3) in lithium-based batteries,aiming to provide scientific guidance for the optimization of electrode/electrolyte interfaces and enrich the design of advanced LMBs.展开更多
Integrated gravitational, electrical-magnetic surveys and data processing carried out in the Sanshandao-Jiaojia area, Eastern Shandong Province, northeast China, aim to illuminate the geological characteristics of thi...Integrated gravitational, electrical-magnetic surveys and data processing carried out in the Sanshandao-Jiaojia area, Eastern Shandong Province, northeast China, aim to illuminate the geological characteristics of this shallow-covered area and delineate deep-seated gold prospecting targets. In this region, altogether 12 faults exert critical control on distribution of three types of Early Precambrian metamorphic rock series, i.e. those in the metamorphic rock area, in the granitic rock area underlying the metamorphic rock, and in the remnant metamorphic rock area in granites, respectively. Additionally, the faults have major effects on distribution of four Mesozoic Linglong rock bodies of granite, i.e. the Cangshang, Liangguo, Zhuqiao-Miaojia and Jincheng granites. The Sanshandao and Jiaojia Faults are two well-known regional ore-controlling faults; they have opposite dip direction, and intersect at a depth of 4500 m. Fracture alteration zones have striking geophysical differences relative to the surrounding county rocks. The two faults extend down along dip direction in a gentle wave form, and appear at some steps with different dips. These steps comprise favorable gold prospecting areas, consistent with a step metallogenic model. Six deep-seated gold-prospecting targets are delineated, i.e. Jincheng-Qianchenjia, Xiaoxizhuang-Zhaoxian, Xiyou-Wujiazhuangzi, Xiangyangling-Xinlicun, Panjiawuzi and Miaojia-Pinglidian.展开更多
This paper describes the interaction between deep-seated landslides and man-made structures such as dams, penstocks, viaducts, and tunnels. Selected case studies are reported first with the intent to gain insights int...This paper describes the interaction between deep-seated landslides and man-made structures such as dams, penstocks, viaducts, and tunnels. Selected case studies are reported first with the intent to gain insights into the complexities associated with the interaction of these structures with deep-seated landslides(generally referred to as deep-seated gravity slope deformations, DSGSDs). The main features, which characterize these landslides, are mentioned together with the interaction problems encountered in each case. Given the main objective of this paper, the numerical modeling methods adopted are outlined as means for increase in the understanding of the interaction problems being investigated. With the above in mind, the attention moves to an important and unique case history dealing with the interaction of a large-size twin-tunnel excavated with an earth pressure balance(EPB)tunnel boring machine(TBM) and a deep-seated landslide, which was reactivated due to the stress changes induced by tunnel excavation in landslide shear zone. The geological and geotechnical conditions are described together with the available monitoring data on the landslide movements, based on the advanced and conventional monitoring tools used. Numerical modeling is illustrated as an aid to back-analyze the monitored surface and subsurface deformations and to assist in finding the appropriate engineering solution for putting the tunnel into service and as a follow-up means for future understanding and control of the interaction problems. The simulation is based on a novel time-dependent model representing the landslide behavior.展开更多
Deep-seated large-scale toppling failure presents unique challenges in the study of natural slope deformation process in mountainous regions.An active deep-seated toppling process was identified in the Erguxi slope lo...Deep-seated large-scale toppling failure presents unique challenges in the study of natural slope deformation process in mountainous regions.An active deep-seated toppling process was identified in the Erguxi slope located in southwest China,which affected a large area and damaged critical transportation infrastructure with the volume of the deforming rock mass exceeding 24×10~6 m^3.It poses significant risks to the downstream Shiziping Hydropower Station by damming the Zagunao River.Field investigation and monitoring results indicate that the deformation of the Erguxi slope is in the advanced stage of deep-seated toppling process,with the formation of a disturbed belt but no identifiable master failure surface.It was postulated that the alternating tensile and shear strength associated with the hard/soft laminated rock strata of metasandstone and phyllite layers preclude the development of either a tensile or shear failure surface,which resulted in the continuous deformation and displacement without a catastrophic mass movement.The slope movement is in close association with the unfavorable geological conditions of the study area in addition to the construction of transportation infrastructure and the increase of the reservoir level.On the basis of the mechanism and intensity of the ongoing toppling deformation,a qualitative grading system was proposed to describe the toppling process and toevaluate the slope stability.This paper summarized the field observation and monitoring data on the toppling deformation for better characterizing its effect on the stability of the Erguxi slope.The qualitative grading system intends to provide a basis for quantitative study of large-scale deep-seated toppling process in metamorphic rocks.展开更多
Deep-seated toppling in the upper reaches of the Lancang River,southwest China involves deformations exceeding 100 m in depth.The slope deformation is initiated by river downcutting and evolves distinctive characteris...Deep-seated toppling in the upper reaches of the Lancang River,southwest China involves deformations exceeding 100 m in depth.The slope deformation is initiated by river downcutting and evolves distinctive characteristics with a depth of river incision.In this study,we propose a system for evaluating the stability of deep-seated toppled slopes in different evolutionary stages.This system contains identification criteria for each evolutionary stage and provides the corresponding stability evaluation methods.Based on the mechanical and kinematic analysis of slope blocks,the specific stage of slope movement can be identified in the field through outcrop mapping,in situ tests,surface displacement monitoring,and adit and borehole explorations.The stability evaluation methods are established based on the limiting equilibrium theory and the strain compatibility between the undisturbed zone and the toppled zone.Finally,several sample slopes in different evolution stages have been investigated to verify the applicability and accuracy of the proposed stability evaluation system.The results indicate that intense tectonic activity and rapid river incision lead to a maximum principal stress ratio exceeding 10 near the slope surface,thus triggering widespread toppling deformations along the river valley.When considering the losses of joint cohesion during the further rotation process,the safety factor of the slope drops by 7%e28%.The self-stabilization of toppling deformation can be recognized by the layer symmetry configuration after the free rotation of the deflected layers.Intensely toppled rock blocks mainly suffer sliding failures beyond the layer symmetry condition.The factor of safety of the K73 rockslide decreased from 1.17 to 0.87 by considering the development of the potential sliding surface and the toesaturated zone.展开更多
Deep-seated rock fractures(referred to as DSRF hereafter)in valley slopes are uncommon geological phenomena that challenge our previous understanding of slope unloading processes.These fractures weaken the strength an...Deep-seated rock fractures(referred to as DSRF hereafter)in valley slopes are uncommon geological phenomena that challenge our previous understanding of slope unloading processes.These fractures weaken the strength and integrity of the rock mass,potentially forming unstable block boundaries with significant volume,thereby affecting the stability of slopes,chambers,and dam abutments.DSRF has emerged as a critical environmental and engineering geological issue that hinders large-scale projects in deep canyon areas.Despite the attention and practical treatment given to DSRF in engineering practice,theoretical research on this topic still lags behind the demands of engineering applications.To garner widespread attention and promote the resolution of DSRF-related problems,this review aims to redefine DSRF through comprehensive data collection and analysis,engineering geological analogies,and field investigations,and provide a summary and analysis of the research progress on DSRF,along with future research directions.The study defines DSRF as the intermittent tension cracks or relaxation zones within a slightly weathered or fresh,and intact or relatively intact rock mass distributed below the surface unloading zones of a deep canyon slope,and should be distinguished from"loose rock mass"and"deep-seated gravitational slope deformations".The article provides an overview of the development and distribution,rupture characteristics,and genesis mechanism of DSRF.It proposes that DSRF is formed based on the fluvial deviation-undercutting evolution mode,wherein the energy accumulated in the rock mass is violently released when the river further down cuts the slope after the rock mass has undergone cyclical loadingunloading.However,further research is necessary to establish a comprehensive database for DSRF,refine exploration techniques,understand evolutionary processes,develop engineering evaluation methods,and predict the distribution of DSRF.展开更多
Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crac...Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire wrapping.The effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also studied.The results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum value.The analysis of the influence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire broke.The increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the influence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline cross-section.The analysis of the temperature effect on the pipeline material,within a range from-40℃to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length decreased.Within such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline significantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of prestressing.This work integrated the existing methods for crack localization along steel gas pipelines.展开更多
The author proves the existence and movement of a deep-seated fraetural Zone located in the eenter zone of the diwa-type faulted basin in central Hebei Province. This deep-seated fraeturai zone tending in NNE directio...The author proves the existence and movement of a deep-seated fraetural Zone located in the eenter zone of the diwa-type faulted basin in central Hebei Province. This deep-seated fraeturai zone tending in NNE direction is a structural effect of the mtodle East Asin Grustobody in the Mexozoic-Cenozoic. This paper will diseuss the formation, evolution and the meehanism of the deep-seated fraetural zone, faulted basin and the buried hills as well as their relationships. The uthor expounds that the deep geological process is the major factor of the structural effect.展开更多
Based on the geology and geochemistry of gold-bearing quartz veins in the Jiudian gold deposit of Pingdu,Shandong Province,the geological and geochemical indicators of occurrence of deep-seated ore bodies in the Jiudi...Based on the geology and geochemistry of gold-bearing quartz veins in the Jiudian gold deposit of Pingdu,Shandong Province,the geological and geochemical indicators of occurrence of deep-seated ore bodies in the Jiudian gold deposit have been summarized.Extent occurrence of wide,intensive,varied alteration zones around the gold-bearing quartz veins and continual presence of diorite porphyrite and lamprophyry indicate the probable occurrence of deep-seated ore bodies at depth of gold lodes.As,Sb and Hg belong to the head halo elements, and their anomalies could reveal the probable occurrence of the deep-seated ore bodies below.展开更多
基金supported financially by the National Key Research and Development Program of China(No.2023YFC3403000)the National Natural Science Foundation of China(No.22378231)the Guangdong Basic and Applied Basic Research Foundation(No.2024A1515012493)。
文摘The efficacy of photodynamic therapy(PDT)for breast tumors is hindered by challenges such as inadequate tumor targeting,limited treatment depth,and strong oxygen dependence.Herein,a promising photosensitizer VP-B was developed to simultaneously address all the aforementioned issues for the treatment of hypoxic deep-seated breast tumors.The biotinylated photosensitizer VP-B not only exhibited precise targeting towards breast tumor tissue,but also efficiently triggered the generation of abundant1O2and O2-·under 690 nm red light irradiation.Indeed,the red light penetration ability enabled VP-B to achieve successful application in a mouse orthotopic breast tumor model.After intravenous administration,VP-B can selectively target tumor tissues and significantly inhibit the growth of hypoxic deep-seated tumors.Therefore,this new typeⅠ&Ⅱphotosensitizer could boost fluorescence-guided photodynamic therapy of other hypoxic solid tumors.
基金supported by Universita della Campania“L.Vanvitelli”,Program VALERE“VAnviteLli pEr la RicErca”(Grant No.516/2018)Italian Ministry of Economic Development#NOACRONYM Project,PoC MISE 2021.
文摘Extensive urban areas worldwide face significant landslide hazards, impacting inhabitants, buildings, and critical infrastructures alike. In the case of slow-moving deep-seated landslides involving huge areas and characterized by complex patterns, when the cost of repairing infrastructures, relocating communities, and restoring cultural sites might be such that it is unsustainable for the community, the exposed structures require significant effort for their surveillance and protection, which can be supported by the development of innovative monitoring systems. For this purpose, a smart extenso-inclinometer, realized by equipping a conventional inclinometer tube with distributed strain and temperature transducers based on optical fiber sensing technology, is presented. In situ monitoring of the active deep-seated San Nicola landslide in Centola (Campania, southern Italy) demonstrated its ability to capture the main features of movements and reconstruct a tridimensional evolution of the landslide pattern, even when the entity of both vertical and horizontal soil strain components is comparable. Although further tests are needed to definitively ascertain the extensometer function of the new device, by interpreting the strain profiles of the landslide body and identifying the achievement of predetermined thresholds, this system could provide a warning of the trigger of a landslide event. The use of the smart extenso-inclinometer within an early warning system for slow-moving landslides holds immense potential for reducing the impact of landslide events.
基金supported by the National Natural Science Foundation of China(No.62464010)Spring City Plan-Special Program for Young Talents(K202005007)+2 种基金Yunnan Talents Support Plan for Young Talents(XDYC-QNRC-2022-0482)Yunnan Local Colleges Applied Basic Research Projects(202101BA070001-138)Frontier Research Team of Kunming University 2023.
文摘Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electrocatalytic reaction kinetics at the cathode.The integration of light energy into Zn/Sn-air batteries is a promising strategy for enhancing their performance.However,the photothermal and photoelectric effects generate heat in the battery under prolonged solar irradiation,leading to air cathode instability.This paper presents the first design and synthesis of Ni_(2)-1,5-diamino-4,8-dihydroxyanthraquinone(Ni_(2)DDA),an electronically conductiveπ-d conjugated metal-organic framework(MOF).Ni_(2)DDA exhibits both photoelectric and photothermal effects,with an optical band gap of~1.14 eV.Under illumination,Ni_(2)DDA achieves excellent oxygen evolution reaction performance(with an overpotential of 245 mV vs.reversible hydrogen electrode at 10 mA cm^(−2))and photothermal stability.These properties result from the synergy between the photoelectric and photothermal effects of Ni_(2)DDA.Upon integration into Zn/Sn-air batteries,Ni_(2)DDA ensures excellent cycling stability under light and exhibits remarkable performance in high-temperature environments up to 80℃.This study experimentally confirms the stable operation of photo-assisted Zn/Sn-air batteries under high-temperature conditions for the first time and provides novel insights into the application of electronically conductive MOFs in photoelectrocatalysis and photothermal catalysis.
基金supported by the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(MSIT)(No.RS-2022-00143178)the Ministry of Education(MOE)(Nos.2022R1A6A3A13053896 and 2022R1F1A1074616),Republic of Korea.
文摘Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.
基金supported by the National Natural Science Foundation of China(No.32170121).
文摘Benzalkonium chloride(BAC)is widely employed as a broad-spectrum biocide and has emerged as a significant environmental pollutant.Polymyxin B(PB)serves as the last-line defense for the treatment of Gram-negative pathogens.Previous studies reported that BAC-adapted Pseudomonas aeruginosa increased the tolerance to PB.Herein,we present the novel finding that the combination of BAC and PB exhibited synergistic antibacterial effects against P.aeruginosa.Time-killing assay demonstrated a significant reduction in bacterial cell viability.Scanning electron microscopy,zeta potential analysis,hydrophobicity measurements,and fluorescence probe analyses collectively revealed severe disruption of the cell envelope and membrane potential induced by the combination of BAC and PB.Transcriptomic analysis revealed that the BAC-PB combination notably downreg-ulated the expression of genes involved in lipid A modification and cell envelope production,including phoPQ,pmrAB,bamABCDE,lptABCDEG,lolB,yidC,and murJ.Additionally,the combination group exhibited augmented production of reactive oxygen species and diminished ATP synthesis.The expression of the genes associated with substance metabolism and energy generation was significantly impeded.This study provides significant implica-tions for the interactions of biocides and antibiotics on Gram-negative pathogens,while also addressing antibiotic resistance and developing the external treatment strategy for Pseudomonas-infected wounds and burns.
基金Supported by the Zhejiang Medical Health Science and Technology Project(No.2021KY217)the Basic Public Welfare Research Project of Wenzhou Municipal Science and Technology Bureau(No.2024Y1221).
文摘AIM:To evaluate and compare alterations in the effective lens position(ELP)and refractive outcomes among three distinct intraocular lens(IOL)types.METHODS:Patients with cataracts were enrolled and allocated to 3 groups:Group A(implanted with the SN6CWS),Group B(implanted with the MI60),and Group C(implanted with the Aspira-aA).ELP measurements were obtained with swept-source optical coherence tomography(SS-OCT)at 1d,1wk,1mo,and 3mo postoperatively.Subjective refraction assessments were conducted at 1wk,1mo,and 3mo following surgery.RESULTS:The study included 189 eyes of 150 cataract patients(66 males).There were 77 eyes in Group A,55 eyes in Group B,and 57 eyes in Group C.The root mean square of the ELP(ELPRMS)within the initial 3mo was significantly lower for Group A than for Groups B and C.Refractive changes within Group A were not significant across the time points of 1wk,1mo,and 3mo.Conversely,both Group B and Group C demonstrated statistically significant shifts toward hyperopia from 1wk to 3mo postsurgery.CONCLUSION:Among the three IOLs examined,the SN6CWS IOL showes the greatest stability during the first 3mo postoperatively.Between 1wk and 3mo after surgery,notable hyperopic shifts are evident in eyes implanted with the MI60 and Aspira-aA IOLs,whereas refractive outcomes remain relatively constant in eyes implanted with SN6CWS IOLs.
文摘Electrical and electronic devices face significant challenges in heatmanagement due to their compact size and high heat flux,which negatively impact performance and reliability.Conventional coolingmethods,such as forced air cooling,often struggle to transfer heat efficiently.In contrast,thermoelectric coolers(TECs)provide an innovative active cooling solution to meet growing thermal management demands.In this research,a refrigerant based on mono ethylene glycol and distilled water was used instead of using gases,in addition to using thermoelectric cooling units instead of using a compressor in traditional refrigeration systems.This study evaluates the performance of a Peltierbased thermalmanagement systemby analyzing the effects of using two,three,and four Peltiermodules on cooling rates,power consumption,temperature reduction,and system efficiency.Experimental results indicate that increasing the number of Peltier modules significantly enhances cooling performance.The four-module system achieved an optimal balance between cooling speed and energy efficiency,reducing the temperature of a liquidmixture(30% mono ethylene glycol+70% distilled water plus laser dyes)to 8℃ in just 17 min.It demonstrated a cooling rate of 0.794℃/min and a high coefficient of performance(COP)of 1.2 while consuming less energy than the two-and three-module systems.Furthermore,the study revealed that increasing the number of modules led to faster air cooling and improved temperature reduction.These findings highlight the importance of selecting the optimal number of Peltier modules to enhance efficiency and cooling speed whileminimizing energy consumption.This makes TEC technology a sustainable and effective solution for applications requiring rapid and reliable thermal management.
基金supported by the National Key Research and Development Program of Chinathe National Natural Science Foundation of China (Grant Nos.2024YFA1408000,12474097,and2023YFA1406001)+2 种基金the Guangdong Provincial Quantum Science Strategic Initiative (Grant No.GDZX2201001)the Center for Computational Science and Engineering at Southern University of Science and Technology,the Major Science and Technology Infrastructure Project of Material Genome Big-science Facilities Platform supported by Municipal Development and Reform Commission of Shenzhen(for J.L.Z.and Y.L.)the Chinese funding sources applied via HPSTAR。
文摘The magnetic properties and Kondo effect in Ce3TiBi5 with a quasi-one-dimensional structure were investigated using in situ high-pressure resistivity measurements up to 48 GPa.At ambient pressure,Ce_(3)TiBi_(5) undergoes an antiferromagnetic(AFM)transition at T_(N)∼5 K.Under high pressures within 8.9 GPa,we find that Kondo scattering contributes differently to the high-temperature resistance,R(T),depending on the applied current direction,demonstrating a significantly anisotropic Kondo effect.The complete P–T phase diagram has been constructed,in which the pressure dependence of T_(N) exhibits a dome-like shape.The AFM order remains robust under pressure,even when the coherence temperature T^(*) far exceeds 300 K.We attribute the observed anisotropic Kondo effect and the robust AFM to the underlying anisotropy in electronic hybridization under high pressure.
基金supported by the CAS Strategic Priority Research Program(No.XDB0760102),the Ministry of Science and Technology of China(No.2022YFF0802501)the Major Science and Technology Infrastructure Maintenance and Transformation Project of the Chinese Academy of Sciences,Shanghai Science and Technology Innovation Action Plan-Phospherus Project(No.23YF1426200)the National Key Research and Development Program of China(No.2024YFE0212200).
文摘In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural and anthropogenic effects on marine aerosols optical properties,as well as the applicability of multi-satellite products and IMPROVE equation.The averaged aerosol optical depth(AOD500 nm)was 0.31±0.16 andÅngström exponent440–675 nm was 0.29±0.30.In offshore China,significant anthropogenic emissions affected the marine environment.In remote WPO,dust aerosols transported from northern China,Siberia,Central Asia,and those settling from the upper troposphere originating from north Africa,Arabian peninsula,and western India,were dominant.The spatial trends of AOD were opposite in the mid-latitude and southern seas of WPO.The highest AOD,0.32±0.23,appeared along the coast of South Asia at mid-latitude,decreasing from offshore seas to remote oceans.In low-latitude and equatorial seas,AOD significantly increased from coast to remote oceans.Ångström exponent dropped significantly from the coast to remote oceans as anthropogenic influence diminished across the entire WPO.Correlation analysis showed that both MODIS-C6 and Himawari AOD prod-ucts showed similar applicability in coastal urban areas,while Himawari AOD is highly recommended for coastal background and marine environment due to its finer resolution.The extinction coefficient derived from PM_(2.5) chemical compositions using IMPROVE algorithm exhibited a significant correlation(R^(2)=0.58)with the con-currently measured AOD in the absence of long-distance transport,suggesting that the IMPROVE is a reasonable proxy of the columnar average of marine aerosol extinctions free from transport influences.
文摘This paper prepared a novel as-cast W-Zr-Ti metallic ESM using high-frequency vacuum induction melting technique.The above ESM performs a typical elastic-brittle material feature and strain rate strengthening behavior.The specimens exhibit violent chemical reaction during the fracture process under the impact loading,and the size distribution of their residual debris follows Rosin-Rammler model.The dynamic fracture toughness is obtained by the fitting of debris length scale,approximately 1.87 MPa·m~(1/2).Microstructure observation on residual debris indicates that the failure process is determined by primary crack propagation under quasi-static compression,while it is affected by multiple cracks propagation in both particle and matrix in the case of dynamic impact.Impact test demonstrates that the novel energetic fragment performs brilliant penetration and combustion effect behind the front target,leading to the effective ignition of fuel tank.For the brittleness of as-cast W-ZrTi ESM,further study conducted bond-based peridynamic(BB-PD)C++computational code to simulate its fracture behavior during penetration.The BB-PD method successfully captured the fracture process and debris cloud formation of the energetic fragment.This paper explores a novel as-cast metallic ESM,and provides an available numerical avenue to the simulation of brittle energetic fragment.
文摘Background:While the treatment of metastatic renal cell carcinoma(mRCC)is evolving due to immune checkpoint inhibitors(ICIs),optimal strategies for later lines of therapy have yet to be defined.The combination of lenvatinib and everolimus represents a viable option,and the present review aimed to summarize its activity,effectiveness,and safety.Methods:A systematic review of the literature was conducted using PubMed,targeting studies published between 2018 and 2025.Eligible studies included English-language prospective and retrospective trials reporting survival outcomes in mRCC patients treated with lenvatinib and everolimus after at least one ICI-containing regimen.Results:Nine studies met the inclusion criteria,encompassing a total of 441 patients.The lenvatinib and everolimus combination was primarily used in the third and subsequent lines of therapy.Median overall survival ranged from 7.5 to 24.5 months,while median progression-free survival was more consistent,between 6.1 and 6.7 months,except for one study reporting 12.9 months.Objective response rates varied widely(14.0%–55.7%).Adverse events of grade≥3 did not exceed the expected rate,with diarrhoea and proteinuria as the most reported events.Dose reductions and treatment discontinuations due to toxicity occurred but were generally lower than in prior pivotal trials.Conclusions:Real-world evidence suggests that lenvatinib and everolimus represent an effective and safe option after ICI failure in mRCC patients.Nevertheless,the lack of randomized phase III trials and the heterogeneity of existing studies highlight the need for more robust prospective research to guide post-ICI therapeutic strategies.
基金supported by the Yunnan Fundamental Research Projects(Grant Nos.202401AU070163 and 202501AT070298)the Yunnan Engineering Research Center Innovation Ability Construction and Enhancement Projects(Grant No.2023-XMDJ-00617107)+5 种基金the University Service Key Industry Project of Yunnan Province(Grant No.FWCY-ZD2024005)the Expert Workstation Support Project of Yunnan Province(Grant No.202405AF140069)the Scientific Research Foundation of Kunming University of Science and Technology(Grant No.20220122)the Analysis and Test Foundation of Kunming University of Science and Technology(Grant No.2023T20220122)the Natural Science Foundation of Inner Mongolia Autonomous Region of China(Grant No.2025QN02057)the Ordos City Strategic Pioneering Science and Technology Special Program for New Energy(Grant No.DC2400003365).
文摘Lithium metal batteries(LMBs)have been regarded as one of the most promising alternatives in the post-lithium battery era due to their high energy density,which meets the needs of light-weight electronic devices and long-range electric vehicles.However,technical barriers such as dendrite growth and poor Li plating/stripping reversibility severely hinder the practical application of LMBs.However,lithium nitrate(LiNO_(3))is found to be able to stabilize the Li/electrolyte interface and has been used to address the above challenges.To date,considerable research efforts have been devoted toward understanding the roles of LiNO_(3) in regulating the surface properties of Li anodes and toward the development of many effective strategies.These research efforts are partially mentioned in some articles on LMBs and yet have not been reviewed systematically.To fill this gap,we discuss the recent advances in fundamental and technological research on LiNO_(3) and its derivatives for improving the performances of LMBs,particularly for Li-sulfur(S),Li-oxygen(O),and Li-Li-containing transition-metal oxide(LTMO)batteries,as well as LiNO_(3)-containing recipes for precursors in battery materials and interphase fabrication.This review pays attention to the effects of LiNO_(3) in lithium-based batteries,aiming to provide scientific guidance for the optimization of electrode/electrolyte interfaces and enrich the design of advanced LMBs.
基金the Geological Science and technology foundation of Shandong Provincial Bureau of Geology and Mineral Resources (Grant No. 20080037)
文摘Integrated gravitational, electrical-magnetic surveys and data processing carried out in the Sanshandao-Jiaojia area, Eastern Shandong Province, northeast China, aim to illuminate the geological characteristics of this shallow-covered area and delineate deep-seated gold prospecting targets. In this region, altogether 12 faults exert critical control on distribution of three types of Early Precambrian metamorphic rock series, i.e. those in the metamorphic rock area, in the granitic rock area underlying the metamorphic rock, and in the remnant metamorphic rock area in granites, respectively. Additionally, the faults have major effects on distribution of four Mesozoic Linglong rock bodies of granite, i.e. the Cangshang, Liangguo, Zhuqiao-Miaojia and Jincheng granites. The Sanshandao and Jiaojia Faults are two well-known regional ore-controlling faults; they have opposite dip direction, and intersect at a depth of 4500 m. Fracture alteration zones have striking geophysical differences relative to the surrounding county rocks. The two faults extend down along dip direction in a gentle wave form, and appear at some steps with different dips. These steps comprise favorable gold prospecting areas, consistent with a step metallogenic model. Six deep-seated gold-prospecting targets are delineated, i.e. Jincheng-Qianchenjia, Xiaoxizhuang-Zhaoxian, Xiyou-Wujiazhuangzi, Xiangyangling-Xinlicun, Panjiawuzi and Miaojia-Pinglidian.
基金support of Spea Ingegneria Europea SpA and Società Autostrade per l’Italia SpA
文摘This paper describes the interaction between deep-seated landslides and man-made structures such as dams, penstocks, viaducts, and tunnels. Selected case studies are reported first with the intent to gain insights into the complexities associated with the interaction of these structures with deep-seated landslides(generally referred to as deep-seated gravity slope deformations, DSGSDs). The main features, which characterize these landslides, are mentioned together with the interaction problems encountered in each case. Given the main objective of this paper, the numerical modeling methods adopted are outlined as means for increase in the understanding of the interaction problems being investigated. With the above in mind, the attention moves to an important and unique case history dealing with the interaction of a large-size twin-tunnel excavated with an earth pressure balance(EPB)tunnel boring machine(TBM) and a deep-seated landslide, which was reactivated due to the stress changes induced by tunnel excavation in landslide shear zone. The geological and geotechnical conditions are described together with the available monitoring data on the landslide movements, based on the advanced and conventional monitoring tools used. Numerical modeling is illustrated as an aid to back-analyze the monitored surface and subsurface deformations and to assist in finding the appropriate engineering solution for putting the tunnel into service and as a follow-up means for future understanding and control of the interaction problems. The simulation is based on a novel time-dependent model representing the landslide behavior.
基金financially supported by the National Natural Science Foundation of China (Grant No.41572302 and Grant No.41130745)the Funds for Creative Research Groups of China (Grant No.41521002)the Open Research Fund from the State Key Laboratory of Geohazard Prevention and Geoenvironment Protection (Chengdu University of Technology) (Grant No.SKLGP2015K001)
文摘Deep-seated large-scale toppling failure presents unique challenges in the study of natural slope deformation process in mountainous regions.An active deep-seated toppling process was identified in the Erguxi slope located in southwest China,which affected a large area and damaged critical transportation infrastructure with the volume of the deforming rock mass exceeding 24×10~6 m^3.It poses significant risks to the downstream Shiziping Hydropower Station by damming the Zagunao River.Field investigation and monitoring results indicate that the deformation of the Erguxi slope is in the advanced stage of deep-seated toppling process,with the formation of a disturbed belt but no identifiable master failure surface.It was postulated that the alternating tensile and shear strength associated with the hard/soft laminated rock strata of metasandstone and phyllite layers preclude the development of either a tensile or shear failure surface,which resulted in the continuous deformation and displacement without a catastrophic mass movement.The slope movement is in close association with the unfavorable geological conditions of the study area in addition to the construction of transportation infrastructure and the increase of the reservoir level.On the basis of the mechanism and intensity of the ongoing toppling deformation,a qualitative grading system was proposed to describe the toppling process and toevaluate the slope stability.This paper summarized the field observation and monitoring data on the toppling deformation for better characterizing its effect on the stability of the Erguxi slope.The qualitative grading system intends to provide a basis for quantitative study of large-scale deep-seated toppling process in metamorphic rocks.
基金supported by the National Natural Science Foundation of China(Grant Nos.42307220 and 42090055)the Postdoctoral Research Project Funding of Shaanxi Province(Grant No.2023BSHEDZZ210).
文摘Deep-seated toppling in the upper reaches of the Lancang River,southwest China involves deformations exceeding 100 m in depth.The slope deformation is initiated by river downcutting and evolves distinctive characteristics with a depth of river incision.In this study,we propose a system for evaluating the stability of deep-seated toppled slopes in different evolutionary stages.This system contains identification criteria for each evolutionary stage and provides the corresponding stability evaluation methods.Based on the mechanical and kinematic analysis of slope blocks,the specific stage of slope movement can be identified in the field through outcrop mapping,in situ tests,surface displacement monitoring,and adit and borehole explorations.The stability evaluation methods are established based on the limiting equilibrium theory and the strain compatibility between the undisturbed zone and the toppled zone.Finally,several sample slopes in different evolution stages have been investigated to verify the applicability and accuracy of the proposed stability evaluation system.The results indicate that intense tectonic activity and rapid river incision lead to a maximum principal stress ratio exceeding 10 near the slope surface,thus triggering widespread toppling deformations along the river valley.When considering the losses of joint cohesion during the further rotation process,the safety factor of the slope drops by 7%e28%.The self-stabilization of toppling deformation can be recognized by the layer symmetry configuration after the free rotation of the deflected layers.Intensely toppled rock blocks mainly suffer sliding failures beyond the layer symmetry condition.The factor of safety of the K73 rockslide decreased from 1.17 to 0.87 by considering the development of the potential sliding surface and the toesaturated zone.
基金supported by the National Natural Science Foundation of China(Grant Nos.41272333)the National Key Research and Development Program of China(Grant Nos.2011CB013501)。
文摘Deep-seated rock fractures(referred to as DSRF hereafter)in valley slopes are uncommon geological phenomena that challenge our previous understanding of slope unloading processes.These fractures weaken the strength and integrity of the rock mass,potentially forming unstable block boundaries with significant volume,thereby affecting the stability of slopes,chambers,and dam abutments.DSRF has emerged as a critical environmental and engineering geological issue that hinders large-scale projects in deep canyon areas.Despite the attention and practical treatment given to DSRF in engineering practice,theoretical research on this topic still lags behind the demands of engineering applications.To garner widespread attention and promote the resolution of DSRF-related problems,this review aims to redefine DSRF through comprehensive data collection and analysis,engineering geological analogies,and field investigations,and provide a summary and analysis of the research progress on DSRF,along with future research directions.The study defines DSRF as the intermittent tension cracks or relaxation zones within a slightly weathered or fresh,and intact or relatively intact rock mass distributed below the surface unloading zones of a deep canyon slope,and should be distinguished from"loose rock mass"and"deep-seated gravitational slope deformations".The article provides an overview of the development and distribution,rupture characteristics,and genesis mechanism of DSRF.It proposes that DSRF is formed based on the fluvial deviation-undercutting evolution mode,wherein the energy accumulated in the rock mass is violently released when the river further down cuts the slope after the rock mass has undergone cyclical loadingunloading.However,further research is necessary to establish a comprehensive database for DSRF,refine exploration techniques,understand evolutionary processes,develop engineering evaluation methods,and predict the distribution of DSRF.
基金funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan(Grant No.AP19680589).
文摘Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire wrapping.The effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also studied.The results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum value.The analysis of the influence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire broke.The increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the influence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline cross-section.The analysis of the temperature effect on the pipeline material,within a range from-40℃to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length decreased.Within such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline significantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of prestressing.This work integrated the existing methods for crack localization along steel gas pipelines.
文摘The author proves the existence and movement of a deep-seated fraetural Zone located in the eenter zone of the diwa-type faulted basin in central Hebei Province. This deep-seated fraeturai zone tending in NNE direction is a structural effect of the mtodle East Asin Grustobody in the Mexozoic-Cenozoic. This paper will diseuss the formation, evolution and the meehanism of the deep-seated fraetural zone, faulted basin and the buried hills as well as their relationships. The uthor expounds that the deep geological process is the major factor of the structural effect.
基金Supported by Project of China Geological Survey(No.1212011085480 )Key Scientific and Technological Development Project of Jilin Province (No.20090479)
文摘Based on the geology and geochemistry of gold-bearing quartz veins in the Jiudian gold deposit of Pingdu,Shandong Province,the geological and geochemical indicators of occurrence of deep-seated ore bodies in the Jiudian gold deposit have been summarized.Extent occurrence of wide,intensive,varied alteration zones around the gold-bearing quartz veins and continual presence of diorite porphyrite and lamprophyry indicate the probable occurrence of deep-seated ore bodies at depth of gold lodes.As,Sb and Hg belong to the head halo elements, and their anomalies could reveal the probable occurrence of the deep-seated ore bodies below.
