This study develops a surrogate super-resolution(SR)framework that accelerates finite element method(FEM)-based computational fluid dynamics(CFD)using deep learning.High-resolution(HR)FEM-based CFDremains computationa...This study develops a surrogate super-resolution(SR)framework that accelerates finite element method(FEM)-based computational fluid dynamics(CFD)using deep learning.High-resolution(HR)FEM-based CFDremains computationally prohibitive for time-sensitive applications,including patient-specific aneurysm hemodynamics where rapid turnaround is valuable.The proposed pipeline learns to reconstruct HR velocity-magnitude fields fromlow-resolution(LR)FEM solutions generated under the same governing equations and boundary conditions.It consistsof three modules:(i)offline pre-training of a residual network on representative vascular geometries;(ii)lightweightfine-tuning to adapt the pretrained model to geometric variability,including patient-specific aneurysm morphologies;and(iii)an unstructured-to-structured sampling strategy with region-of-interest upsampling that concentrates resolution in flow-critical zones(e.g.,the aneurysm sac)rather than the full domain.This targeted reconstruction substantiallyreduces inference and post-processing cost while preserving key HR flow features.Experiments on cerebral aneurysmmodels show that HR velocity-magnitude fields can be recovered with accuracy comparable to direct HR simulationsat less than 1%of the direct HR simulation cost per analysis(LR simulation and SR inference),while adaptation to newgeometries requires only lightweight fine-tuning with limited target-specific HR data.While clinical endpoints andadditional variables(e.g.,pressure or wall-based metrics)are left for future work,the results indicate that the proposedsurrogate SR approach can streamline FEM-based CFD workflows toward near real-time hemodynamic analysis acrossmorphologically similar vascular models.展开更多
Remote sensing image super-resolution technology is pivotal for enhancing image quality in critical applications including environmental monitoring,urban planning,and disaster assessment.However,traditional methods ex...Remote sensing image super-resolution technology is pivotal for enhancing image quality in critical applications including environmental monitoring,urban planning,and disaster assessment.However,traditional methods exhibit deficiencies in detail recovery and noise suppression,particularly when processing complex landscapes(e.g.,forests,farmlands),leading to artifacts and spectral distortions that limit practical utility.To address this,we propose an enhanced Super-Resolution Generative Adversarial Network(SRGAN)framework featuring three key innovations:(1)Replacement of L1/L2 loss with a robust Charbonnier loss to suppress noise while preserving edge details via adaptive gradient balancing;(2)A multi-loss joint optimization strategy dynamically weighting Charbonnier loss(β=0.5),Visual Geometry Group(VGG)perceptual loss(α=1),and adversarial loss(γ=0.1)to synergize pixel-level accuracy and perceptual quality;(3)A multi-scale residual network(MSRN)capturing cross-scale texture features(e.g.,forest canopies,mountain contours).Validated on Sentinel-2(10 m)and SPOT-6/7(2.5 m)datasets covering 904 km2 in Motuo County,Xizang,our method outperforms the SRGAN baseline(SR4RS)with Peak Signal-to-Noise Ratio(PSNR)gains of 0.29 dB and Structural Similarity Index(SSIM)improvements of 3.08%on forest imagery.Visual comparisons confirm enhanced texture continuity despite marginal Learned Perceptual Image Patch Similarity(LPIPS)increases.The method significantly improves noise robustness and edge retention in complex geomorphology,demonstrating 18%faster response in forest fire early warning and providing high-resolution support for agricultural/urban monitoring.Future work will integrate spectral constraints and lightweight architectures.展开更多
Accurate forecasting of tropical cyclone(TC)tracks and intensities is essential.Although the TianXing large weather model,a six-hourly forecasting model surpassing operational forecasts,exhibits superior performance,i...Accurate forecasting of tropical cyclone(TC)tracks and intensities is essential.Although the TianXing large weather model,a six-hourly forecasting model surpassing operational forecasts,exhibits superior performance,its TC forecasts still require enhancement.Prediction errors persist due to biases in the training data and smoothing effects in data-driven methods.To address this,we introduce CycloneBCNet,a deep-learning model designed to correct TianXing’s TC forecast biases by leveraging spatial and temporal data.CycloneBCNet utilizes the SimVP(simpler yet better video prediction)framework with spatial attention to highlight cyclone core regions in forecast fields.It also incorporates TC trend information(center position,maximum wind speed,and minimum sea level pressure)via an LSTM(long short-term memory)module.These TC vectors are derived from post-processed TianXing forecasts.By fusing features from forecast fields and TC vectors,CycloneBCNet corrects biases across multiple lead times.At a 96-h lead time,the track error reduces from 162.4 to 86.4 km,the wind speed error from 17.2 to 6.69 m s^(-1),and the pressure error from 22.2 to 9.36 hPa.Interpretability analysis shows that CycloneBCNet adjusts its attention across forecast lead times.Intensity corrections prioritize inner-core dynamics,particularly the eye and eyewall,while track corrections shift from lower-level variables and the cyclone’s core to broader environmental factors and mid-to upper-level features as the forecast duration increases.These findings demonstrate that CycloneBCNet effectively captures key TC dynamics consistent with meteorological principles,including the dominance of near-surface conditions for intensity and the increasing influence of steering currents on track prediction.展开更多
Alzheimer’s Disease(AD)is a progressive neurodegenerative disorder that significantly affects cognitive function,making early and accurate diagnosis essential.Traditional Deep Learning(DL)-based approaches often stru...Alzheimer’s Disease(AD)is a progressive neurodegenerative disorder that significantly affects cognitive function,making early and accurate diagnosis essential.Traditional Deep Learning(DL)-based approaches often struggle with low-contrast MRI images,class imbalance,and suboptimal feature extraction.This paper develops a Hybrid DL system that unites MobileNetV2 with adaptive classification methods to boost Alzheimer’s diagnosis by processing MRI scans.Image enhancement is done using Contrast-Limited Adaptive Histogram Equalization(CLAHE)and Enhanced Super-Resolution Generative Adversarial Networks(ESRGAN).A classification robustness enhancement system integrates class weighting techniques and a Matthews Correlation Coefficient(MCC)-based evaluation method into the design.The trained and validated model gives a 98.88%accuracy rate and 0.9614 MCC score.We also performed a 10-fold cross-validation experiment with an average accuracy of 96.52%(±1.51),a loss of 0.1671,and an MCC score of 0.9429 across folds.The proposed framework outperforms the state-of-the-art models with a 98%weighted F1-score while decreasing misdiagnosis results for every AD stage.The model demonstrates apparent separation abilities between AD progression stages according to the results of the confusion matrix analysis.These results validate the effectiveness of hybrid DL models with adaptive preprocessing for early and reliable Alzheimer’s diagnosis,contributing to improved computer-aided diagnosis(CAD)systems in clinical practice.展开更多
Modern industrial environments require uninterrupted machinery operation to maintain productivity standards while ensuring safety and minimizing costs.Conventional maintenance methods,such as reactive maintenance(i.e....Modern industrial environments require uninterrupted machinery operation to maintain productivity standards while ensuring safety and minimizing costs.Conventional maintenance methods,such as reactive maintenance(i.e.,run to failure)or time-based preventive maintenance(i.e.,scheduled servicing),prove ineffective for complex systems with many Internet of Things(IoT)devices and sensors because they fall short in detecting faults at early stages when it is most crucial.This paper presents a predictive maintenance framework based on a hybrid deep learning model that integrates the capabilities of Long Short-Term Memory(LSTM)Networks and Convolutional Neural Networks(CNNs).The framework integrates spatial feature extraction and temporal sequence modeling to accurately classify the health state of industrial equipment into three categories,including Normal,Require Maintenance,and Failed.The framework uses a modular pipeline that includes IoT-enabled data collection along with secure transmission methods to manage cloud storage and provide real-time fault classification.The FD004 subset of the NASA C-MAPSS dataset,containing multivariate sensor readings from aircraft engines,serves as the training and evaluation data for the model.Experimental results show that the LSTM-CNN model outperforms baseline models such as LSTM-SVM and LSTM-RNN,achieving an overall average accuracy of 86.66%,precision of 86.00%,recall of 86.33%,and F1-score of 86.33%.Contrary to the previous LSTM-CNN-based predictive maintenance models that either provide a binary classification or rely on synthetically balanced data,our paper provides a three-class maintenance state(i.e.,Normal,Require Maintenance,and Failed)along with threshold-based labeling that retains the true nature of the degradation.In addition,our work also provides an IoT-to-cloud-based modular architecture for deployment.It offers Computerized Maintenance Management System(CMMS)integration,making our proposed solution not only technically sound but also practical and innovative.The solution achieves real-world industrial deployment readiness through its reliable performance alongside its scalable system design.展开更多
With the growing demand for high-precision flow field simulations in computational science and engineering,the super-resolution reconstruction of physical fields has attracted considerable research interest.However,tr...With the growing demand for high-precision flow field simulations in computational science and engineering,the super-resolution reconstruction of physical fields has attracted considerable research interest.However,tradi-tional numerical methods often entail high computational costs,involve complex data processing,and struggle to capture fine-scale high-frequency details.To address these challenges,we propose an innovative super-resolution reconstruction framework that integrates a Fourier neural operator(FNO)with an enhanced diffusion model.The framework employs an adaptively weighted FNO to process low-resolution flow field inputs,effectively capturing global dependencies and high-frequency features.Furthermore,a residual-guided diffusion model is introduced to further improve reconstruction performance.This model uses a Markov chain for noise injection in phys-ical fields and integrates a reverse denoising procedure,efficiently solved by an adaptive time-step ordinary differential equation solver,thereby ensuring both stability and computational efficiency.Experimental results demonstrate that the proposed framework significantly outperforms existing methods in terms of accuracy and efficiency,offering a promising solution for fine-grained data reconstruction in scientific simulations.展开更多
Single image super-resolution has attracted increasing attention and has a wide range of applications in satellite imaging, medical imaging, computer vision, security surveillance imaging, remote sensing, objection de...Single image super-resolution has attracted increasing attention and has a wide range of applications in satellite imaging, medical imaging, computer vision, security surveillance imaging, remote sensing, objection detection, and recognition. Recently, deep learning techniques have emerged and blossomed, producing " the state-of-the-art” in many domains. Due to their capability in feature extraction and mapping, it is very helpful to predict high-frequency details lost in low-resolution images. In this paper, we give an overview of recent advances in deep learning-based models and methods that have been applied to single image super-resolution tasks. We also summarize, compare and discuss various models from the past and present for comprehensive understanding and finally provide open problems and possible directions for future research.展开更多
Hyperspectral image super-resolution,which refers to reconstructing the high-resolution hyperspectral image from the input low-resolution observation,aims to improve the spatial resolution of the hyperspectral image,w...Hyperspectral image super-resolution,which refers to reconstructing the high-resolution hyperspectral image from the input low-resolution observation,aims to improve the spatial resolution of the hyperspectral image,which is beneficial for subsequent applications.The development of deep learning has promoted significant progress in hyperspectral image super-resolution,and the powerful expression capabilities of deep neural networks make the predicted results more reliable.Recently,several latest deep learning technologies have made the hyperspectral image super-resolution method explode.However,a comprehensive review and analysis of the latest deep learning methods from the hyperspectral image super-resolution perspective is absent.To this end,in this survey,we first introduce the concept of hyperspectral image super-resolution and classify the methods from the perspectives with or without auxiliary information.Then,we review the learning-based methods in three categories,including single hyperspectral image super-resolution,panchromatic-based hyperspectral image super-resolution,and multispectral-based hyperspectral image super-resolution.Subsequently,we summarize the commonly used hyperspectral dataset,and the evaluations for some representative methods in three categories are performed qualitatively and quantitatively.Moreover,we briefly introduce several typical applications of hyperspectral image super-resolution,including ground object classification,urban change detection,and ecosystem monitoring.Finally,we provide the conclusion and challenges in existing learning-based methods,looking forward to potential future research directions.展开更多
A coupled thermal-hydro-mechanical cohesive phase-field model for hydraulic fracturing in deep coal seams is presented.Heat exchange between the cold fluid and the hot rock is considered,and the thermal contribution t...A coupled thermal-hydro-mechanical cohesive phase-field model for hydraulic fracturing in deep coal seams is presented.Heat exchange between the cold fluid and the hot rock is considered,and the thermal contribution terms between the cold fluid and the hot rock are derived.Heat transfer obeys Fourier's law,and porosity is used to relate the thermodynamic parameters of the fracture and matrix domains.The net pressure difference between the fracture and the matrix is neglected,and thus the fluid flow is modeled by the unified fluid-governing equations.The evolution equations of porosity and Biot's coefficient during hydraulic fracturing are derived from their definitions.The effect of coal cleats is considered and modeled by Voronoi polygons,and this approach is shown to have high accuracy.The accuracy of the proposed model is verified by two sets of fracturing experiments in multilayer coal seams.Subsequently,the differences in fracture morphology,fluid pressure response,and fluid pressure distribution between direct fracturing of coal seams and indirect fracturing of shale interlayers are explored,and the effects of the cluster number and cluster spacing on fracture morphology for multi-cluster fracturing are also examined.The numerical results show that the proposed model is expected to be a powerful tool for the fracturing design and optimization of deep coalbed methane.展开更多
Hyper Spectral Image Super-Resolution(HSI-SR) has gained significant attention in recent years due to its potential applications.However,the challenge of obtaining high-resolution hyperspectral images is compounded by...Hyper Spectral Image Super-Resolution(HSI-SR) has gained significant attention in recent years due to its potential applications.However,the challenge of obtaining high-resolution hyperspectral images is compounded by limitations in sensor resolution and the high dimensionality of spectral data.Traditional approaches,including interpolation-based methods and sparse representation techniques,often struggle to capture the intricate spectral-spatial dependencies in hyperspectral images.To address these limitations,this study proposes a Hadamard Self-Attention Network(HSAN) for fusing a High-resolution Multispectral Image(Hr-MSI) and a Low-resolution Hyper Spectral Image(Lr-HSI),achieving HSI-SR for obtaining a High-resolution Hyper Spectral Image(Hr-HSI).The core of HSAN is a new Hadamard self-attention mechanism that can be more efficient than traditional dot-product attention because it avoids matrix multiplications and softmax operations.Considering that deep learning-based data fusion typically entails a significant computational and storage burden,this new approach can be integrated with convolutional layers to form an unsupervised lightweight network,which significantly reduces dependence on computational resources.Experimental results across four datasets validate the effectiveness and advantages of HSAN,compared with state-of-the-art approaches.The source code will be available at https://github.com/zxnhkdm/HSAN.展开更多
Porosity is an important attribute for evaluating the petrophysical properties of reservoirs, and has guiding significance for the exploration and development of oil and gas. The seismic inversion is a key method for ...Porosity is an important attribute for evaluating the petrophysical properties of reservoirs, and has guiding significance for the exploration and development of oil and gas. The seismic inversion is a key method for comprehensively obtaining the porosity. Deep learning methods provide an intelligent approach to suppress the ambiguity of the conventional inversion method. However, under the trace-bytrace inversion strategy, there is a lack of constraints from geological structural information, resulting in poor lateral continuity of prediction results. In addition, the heterogeneity and the sedimentary variability of subsurface media also lead to uncertainty in intelligent prediction. To achieve fine prediction of porosity, we consider the lateral continuity and variability and propose an improved structural modeling deep learning porosity prediction method. First, we combine well data, waveform attributes, and structural information as constraints to model geophysical parameters, constructing a high-quality training dataset with sedimentary facies-controlled significance. Subsequently, we introduce a gated axial attention mechanism to enhance the features of dataset and design a bidirectional closed-loop network system constrained by inversion and forward processes. The constraint coefficient is adaptively adjusted by the petrophysical information contained between the porosity and impedance in the study area. We demonstrate the effectiveness of the adaptive coefficient through numerical experiments.Finally, we compare the performance differences between the proposed method and conventional deep learning methods using data from two study areas. The proposed method achieves better consistency with the logging porosity, demonstrating the superiority of the proposed method.展开更多
Significant advancements have been achieved in the field of Single Image Super-Resolution(SISR)through the utilization of Convolutional Neural Networks(CNNs)to attain state-of-the-art performance.Recent efforts have e...Significant advancements have been achieved in the field of Single Image Super-Resolution(SISR)through the utilization of Convolutional Neural Networks(CNNs)to attain state-of-the-art performance.Recent efforts have explored the incorporation of Transformers to augment network performance in SISR.However,the high computational cost of Transformers makes them less suitable for deployment on lightweight devices.Moreover,the majority of enhancements for CNNs rely predominantly on small spatial convolutions,thereby neglecting the potential advantages of large kernel convolution.In this paper,the authors propose a Multi-Perception Large Kernel convNet(MPLKN)which delves into the exploration of large kernel convolution.Specifically,the authors have architected a Multi-Perception Large Kernel(MPLK)module aimed at extracting multi-scale features and employ a stepwise feature fusion strategy to seamlessly integrate these features.In addition,to enhance the network's capacity for nonlinear spatial information processing,the authors have designed a Spatial-Channel Gated Feed-forward Network(SCGFN)that is capable of adapting to feature interactions across both spatial and channel dimensions.Experimental results demonstrate that MPLKN outperforms other lightweight image super-resolution models while maintaining a minimal number of parameters and FLOPs.展开更多
The algorithm used for reconstruction or resolution enhancement is one of the factors affectingthe quality of super-resolution images obtained by fluorescence microscopy.Deep-learning-basedalgorithms have achieved sta...The algorithm used for reconstruction or resolution enhancement is one of the factors affectingthe quality of super-resolution images obtained by fluorescence microscopy.Deep-learning-basedalgorithms have achieved stateof-the-art performance in super-resolution fluorescence micros-copy and are becoming increasingly attractive.We firstly introduce commonly-used deep learningmodels,and then review the latest applications in terms of the net work architectures,the trainingdata and the loss functions.Additionally,we discuss the challenges and limits when using deeplearning to analyze the fluorescence microscopic data,and suggest ways to improve the reliability and robustness of deep learning applications.展开更多
Rock residual strength,as an important input parameter,plays an indispensable role in proposing the reasonable and scientific scheme about stope design,underground tunnel excavation and stability evaluation of deep ch...Rock residual strength,as an important input parameter,plays an indispensable role in proposing the reasonable and scientific scheme about stope design,underground tunnel excavation and stability evaluation of deep chambers.Therefore,previous residual strength models of rocks established were reviewed.And corresponding related problems were stated.Subsequently,starting from the effects of bedding and whole life-cycle evolution process,series of triaxial mechanical tests of deep bedded sandstone with five bedding angles were conducted under different confining pressures.Then,six residual strength models considering the effects of bedding and whole life-cycle evolution process were established and evaluated.Finally,a cohesion loss model for determining residual strength of deep bedded sandstone was verified.The results showed that the effects of bedding and whole life-cycle evolution process had both significant influences on the evolution characteristic of residual strength of deep bedded sandstone.Additionally,residual strength parameters:residual cohesion and residual internal friction angle of deep bedded sandstone were not constant,which both significantly changed with increasing bedding angle.Besides,the cohesion loss model was the most suitable for determining and estimating the residual strength of bedded rocks,which could provide more accurate theoretical guidance for the stability control of deep chambers.展开更多
Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 km.Because they can significantly influence radio communications and navigation systems,...Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 km.Because they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite systems.In this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde observations.The deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular.展开更多
Single image super-resolution(SISR)is a fundamentally challenging problem because a low-resolution(LR)image can correspond to a set of high-resolution(HR)images,while most are not expected.Recently,SISR can be achieve...Single image super-resolution(SISR)is a fundamentally challenging problem because a low-resolution(LR)image can correspond to a set of high-resolution(HR)images,while most are not expected.Recently,SISR can be achieved by a deep learning-based method.By constructing a very deep super-resolution convolutional neural network(VDSRCNN),the LR images can be improved to HR images.This study mainly achieves two objectives:image super-resolution(ISR)and deblurring the image from VDSRCNN.Firstly,by analyzing ISR,we modify different training parameters to test the performance of VDSRCNN.Secondly,we add the motion blurred images to the training set to optimize the performance of VDSRCNN.Finally,we use image quality indexes to evaluate the difference between the images from classical methods and VDSRCNN.The results indicate that the VDSRCNN performs better in generating HR images from LR images using the optimized VDSRCNN in a proper method.展开更多
This paper develops a deep estimator framework of deep convolution networks(DCNs)for super-resolution direction of arrival(DOA)estimation.In addition to the scenario of correlated signals,the quantization errors of th...This paper develops a deep estimator framework of deep convolution networks(DCNs)for super-resolution direction of arrival(DOA)estimation.In addition to the scenario of correlated signals,the quantization errors of the DCN are the major challenge.In our deep estimator framework,one DCN is used for spectrum estimation with quantization errors,and the remaining two DCNs are used to estimate quantization errors.We propose training our estimator using the spatial sampled covariance matrix directly as our deep estimator’s input without any feature extraction operation.Then,we reconstruct the original spatial spectrum from the spectrum estimate and quantization errors estimate.Also,the feasibility of the proposed deep estimator is analyzed in detail in this paper.Once the deep estimator is appropriately trained,it can recover the correlated signals’spatial spectrum fast and accurately.Simulation results show that our estimator performs well in both resolution and estimation error compared with the state-of-the-art algorithms.展开更多
Image super-resolution(SR)is an important technique for improving the resolution and quality of images.With the great progress of deep learning,image super-resolution achieves remarkable improvements recently.In this ...Image super-resolution(SR)is an important technique for improving the resolution and quality of images.With the great progress of deep learning,image super-resolution achieves remarkable improvements recently.In this work,a brief survey on recent advances of deep learning based single image super-resolution methods is systematically described.The existing studies of SR techniques are roughly grouped into ten major categories.Besides,some other important issues are also introduced,such as publicly available benchmark datasets and performance evaluation metrics.Finally,this survey is concluded by highlighting four future trends.展开更多
The evaluation of adsorption states and shale gas content in shale fractures and pores relies on the analysis of these fractures and pores.Scanning electron microscopy images are commonly used for shale analysis;howev...The evaluation of adsorption states and shale gas content in shale fractures and pores relies on the analysis of these fractures and pores.Scanning electron microscopy images are commonly used for shale analysis;however,their low resolution,particularly the loss of high-frequency information at pore edges,presents challenges in analyzing fractures and pores in shale gas reservoirs.This study introduced a novel neural network called the spatial-spectral domain attention network(SSDAN),which employed spatial and spectral domain attention mechanisms to extract features and restore information in parallel.The network generated super-resolution images through a fusion module that included CNN-based spatial blocks for pixel-level image information recovery,spectral blocks to process Fourier transform information of images and enhance high-frequency recovery,and an adaptive vision transformer to process Fourier transform block information,eliminating the need for a preset image size.The SSDAN model demonstrated exceptional performance in comparative experiments on marine shale and marine continental shale datasets,achieving optimal performance on key indicators such as peak signal-to-noise ratio,structural similarity,learned perceptual image patch similarity,and Frechet inception distance while also exhibiting superior visual performance in pore recovery.Ablation experiments further confirmed the effectiveness of the spatial blocks,channel attention,spectral blocks,and frequency loss function in the model.The SSDAN model showed remarkable capability in enhancing the resolution of shale gas reservoir images and restoring high-frequency information at pore edges,thereby validating its effectiveness in unconventional natural gas reservoir analyses.展开更多
Predicting cross-immunity between viral strains is vital for public health surveillance and vaccine development.Traditional neural network methods,such as BiLSTM,could be ineffective due to the lack of lab data for mo...Predicting cross-immunity between viral strains is vital for public health surveillance and vaccine development.Traditional neural network methods,such as BiLSTM,could be ineffective due to the lack of lab data for model training and the overshadowing of crucial features within sequence concatenation.The current work proposes a less data-consuming model incorporating a pre-trained gene sequence model and a mutual information inference operator.Our methodology utilizes gene alignment and deduplication algorithms to preprocess gene sequences,enhancing the model’s capacity to discern and focus on distinctions among input gene pairs.The model,i.e.,DNA Pretrained Cross-Immunity Protection Inference model(DPCIPI),outperforms state-of-theart(SOTA)models in predicting hemagglutination inhibition titer from influenza viral gene sequences only.Improvement in binary cross-immunity prediction is 1.58%in F1,2.34%in precision,1.57%in recall,and 1.57%in Accuracy.For multilevel cross-immunity improvements,the improvement is 2.12%in F1,3.50%in precision,2.19%in recall,and 2.19%in Accuracy.Our study showcases the potential of pre-trained gene models to improve predictions of antigenic variation and cross-immunity.With expanding gene data and advancements in pre-trained models,this approach promises significant impacts on vaccine development and public health.展开更多
文摘This study develops a surrogate super-resolution(SR)framework that accelerates finite element method(FEM)-based computational fluid dynamics(CFD)using deep learning.High-resolution(HR)FEM-based CFDremains computationally prohibitive for time-sensitive applications,including patient-specific aneurysm hemodynamics where rapid turnaround is valuable.The proposed pipeline learns to reconstruct HR velocity-magnitude fields fromlow-resolution(LR)FEM solutions generated under the same governing equations and boundary conditions.It consistsof three modules:(i)offline pre-training of a residual network on representative vascular geometries;(ii)lightweightfine-tuning to adapt the pretrained model to geometric variability,including patient-specific aneurysm morphologies;and(iii)an unstructured-to-structured sampling strategy with region-of-interest upsampling that concentrates resolution in flow-critical zones(e.g.,the aneurysm sac)rather than the full domain.This targeted reconstruction substantiallyreduces inference and post-processing cost while preserving key HR flow features.Experiments on cerebral aneurysmmodels show that HR velocity-magnitude fields can be recovered with accuracy comparable to direct HR simulationsat less than 1%of the direct HR simulation cost per analysis(LR simulation and SR inference),while adaptation to newgeometries requires only lightweight fine-tuning with limited target-specific HR data.While clinical endpoints andadditional variables(e.g.,pressure or wall-based metrics)are left for future work,the results indicate that the proposedsurrogate SR approach can streamline FEM-based CFD workflows toward near real-time hemodynamic analysis acrossmorphologically similar vascular models.
基金This study was supported by:Inner Mongolia Academy of Forestry Sciences Open Research Project(Grant No.KF2024MS03)The Project to Improve the Scientific Research Capacity of the Inner Mongolia Academy of Forestry Sciences(Grant No.2024NLTS04)The Innovation and Entrepreneurship Training Program for Undergraduates of Beijing Forestry University(Grant No.X202410022268).
文摘Remote sensing image super-resolution technology is pivotal for enhancing image quality in critical applications including environmental monitoring,urban planning,and disaster assessment.However,traditional methods exhibit deficiencies in detail recovery and noise suppression,particularly when processing complex landscapes(e.g.,forests,farmlands),leading to artifacts and spectral distortions that limit practical utility.To address this,we propose an enhanced Super-Resolution Generative Adversarial Network(SRGAN)framework featuring three key innovations:(1)Replacement of L1/L2 loss with a robust Charbonnier loss to suppress noise while preserving edge details via adaptive gradient balancing;(2)A multi-loss joint optimization strategy dynamically weighting Charbonnier loss(β=0.5),Visual Geometry Group(VGG)perceptual loss(α=1),and adversarial loss(γ=0.1)to synergize pixel-level accuracy and perceptual quality;(3)A multi-scale residual network(MSRN)capturing cross-scale texture features(e.g.,forest canopies,mountain contours).Validated on Sentinel-2(10 m)and SPOT-6/7(2.5 m)datasets covering 904 km2 in Motuo County,Xizang,our method outperforms the SRGAN baseline(SR4RS)with Peak Signal-to-Noise Ratio(PSNR)gains of 0.29 dB and Structural Similarity Index(SSIM)improvements of 3.08%on forest imagery.Visual comparisons confirm enhanced texture continuity despite marginal Learned Perceptual Image Patch Similarity(LPIPS)increases.The method significantly improves noise robustness and edge retention in complex geomorphology,demonstrating 18%faster response in forest fire early warning and providing high-resolution support for agricultural/urban monitoring.Future work will integrate spectral constraints and lightweight architectures.
基金supported by the Meteorological Joint Funds of the National Natural Science Foundation of China(Grant No.U2142211)the National Natural Science Foundation of China(Grant Nos.42075141,42341202 and 62088101)+1 种基金the National Key Research and Development Program of China(Grant No.2020YFA0608000)the Shanghai Municipal Science and Technology Major Project(Grant No.2021SHZDZX0100).
文摘Accurate forecasting of tropical cyclone(TC)tracks and intensities is essential.Although the TianXing large weather model,a six-hourly forecasting model surpassing operational forecasts,exhibits superior performance,its TC forecasts still require enhancement.Prediction errors persist due to biases in the training data and smoothing effects in data-driven methods.To address this,we introduce CycloneBCNet,a deep-learning model designed to correct TianXing’s TC forecast biases by leveraging spatial and temporal data.CycloneBCNet utilizes the SimVP(simpler yet better video prediction)framework with spatial attention to highlight cyclone core regions in forecast fields.It also incorporates TC trend information(center position,maximum wind speed,and minimum sea level pressure)via an LSTM(long short-term memory)module.These TC vectors are derived from post-processed TianXing forecasts.By fusing features from forecast fields and TC vectors,CycloneBCNet corrects biases across multiple lead times.At a 96-h lead time,the track error reduces from 162.4 to 86.4 km,the wind speed error from 17.2 to 6.69 m s^(-1),and the pressure error from 22.2 to 9.36 hPa.Interpretability analysis shows that CycloneBCNet adjusts its attention across forecast lead times.Intensity corrections prioritize inner-core dynamics,particularly the eye and eyewall,while track corrections shift from lower-level variables and the cyclone’s core to broader environmental factors and mid-to upper-level features as the forecast duration increases.These findings demonstrate that CycloneBCNet effectively captures key TC dynamics consistent with meteorological principles,including the dominance of near-surface conditions for intensity and the increasing influence of steering currents on track prediction.
基金funded by the Deanship of Graduate Studies and Scientific Research at Jouf University under grant No.(DGSSR-2025-02-01295).
文摘Alzheimer’s Disease(AD)is a progressive neurodegenerative disorder that significantly affects cognitive function,making early and accurate diagnosis essential.Traditional Deep Learning(DL)-based approaches often struggle with low-contrast MRI images,class imbalance,and suboptimal feature extraction.This paper develops a Hybrid DL system that unites MobileNetV2 with adaptive classification methods to boost Alzheimer’s diagnosis by processing MRI scans.Image enhancement is done using Contrast-Limited Adaptive Histogram Equalization(CLAHE)and Enhanced Super-Resolution Generative Adversarial Networks(ESRGAN).A classification robustness enhancement system integrates class weighting techniques and a Matthews Correlation Coefficient(MCC)-based evaluation method into the design.The trained and validated model gives a 98.88%accuracy rate and 0.9614 MCC score.We also performed a 10-fold cross-validation experiment with an average accuracy of 96.52%(±1.51),a loss of 0.1671,and an MCC score of 0.9429 across folds.The proposed framework outperforms the state-of-the-art models with a 98%weighted F1-score while decreasing misdiagnosis results for every AD stage.The model demonstrates apparent separation abilities between AD progression stages according to the results of the confusion matrix analysis.These results validate the effectiveness of hybrid DL models with adaptive preprocessing for early and reliable Alzheimer’s diagnosis,contributing to improved computer-aided diagnosis(CAD)systems in clinical practice.
文摘Modern industrial environments require uninterrupted machinery operation to maintain productivity standards while ensuring safety and minimizing costs.Conventional maintenance methods,such as reactive maintenance(i.e.,run to failure)or time-based preventive maintenance(i.e.,scheduled servicing),prove ineffective for complex systems with many Internet of Things(IoT)devices and sensors because they fall short in detecting faults at early stages when it is most crucial.This paper presents a predictive maintenance framework based on a hybrid deep learning model that integrates the capabilities of Long Short-Term Memory(LSTM)Networks and Convolutional Neural Networks(CNNs).The framework integrates spatial feature extraction and temporal sequence modeling to accurately classify the health state of industrial equipment into three categories,including Normal,Require Maintenance,and Failed.The framework uses a modular pipeline that includes IoT-enabled data collection along with secure transmission methods to manage cloud storage and provide real-time fault classification.The FD004 subset of the NASA C-MAPSS dataset,containing multivariate sensor readings from aircraft engines,serves as the training and evaluation data for the model.Experimental results show that the LSTM-CNN model outperforms baseline models such as LSTM-SVM and LSTM-RNN,achieving an overall average accuracy of 86.66%,precision of 86.00%,recall of 86.33%,and F1-score of 86.33%.Contrary to the previous LSTM-CNN-based predictive maintenance models that either provide a binary classification or rely on synthetically balanced data,our paper provides a three-class maintenance state(i.e.,Normal,Require Maintenance,and Failed)along with threshold-based labeling that retains the true nature of the degradation.In addition,our work also provides an IoT-to-cloud-based modular architecture for deployment.It offers Computerized Maintenance Management System(CMMS)integration,making our proposed solution not only technically sound but also practical and innovative.The solution achieves real-world industrial deployment readiness through its reliable performance alongside its scalable system design.
基金supported by the National Natural Science Foundation of China(Grant Nos.42005003 and 41475094)National Key R&D Program of China(Grant No.2018YFC1506704).
文摘With the growing demand for high-precision flow field simulations in computational science and engineering,the super-resolution reconstruction of physical fields has attracted considerable research interest.However,tradi-tional numerical methods often entail high computational costs,involve complex data processing,and struggle to capture fine-scale high-frequency details.To address these challenges,we propose an innovative super-resolution reconstruction framework that integrates a Fourier neural operator(FNO)with an enhanced diffusion model.The framework employs an adaptively weighted FNO to process low-resolution flow field inputs,effectively capturing global dependencies and high-frequency features.Furthermore,a residual-guided diffusion model is introduced to further improve reconstruction performance.This model uses a Markov chain for noise injection in phys-ical fields and integrates a reverse denoising procedure,efficiently solved by an adaptive time-step ordinary differential equation solver,thereby ensuring both stability and computational efficiency.Experimental results demonstrate that the proposed framework significantly outperforms existing methods in terms of accuracy and efficiency,offering a promising solution for fine-grained data reconstruction in scientific simulations.
基金the support from the Shanxi Hundred People Plan of China
文摘Single image super-resolution has attracted increasing attention and has a wide range of applications in satellite imaging, medical imaging, computer vision, security surveillance imaging, remote sensing, objection detection, and recognition. Recently, deep learning techniques have emerged and blossomed, producing " the state-of-the-art” in many domains. Due to their capability in feature extraction and mapping, it is very helpful to predict high-frequency details lost in low-resolution images. In this paper, we give an overview of recent advances in deep learning-based models and methods that have been applied to single image super-resolution tasks. We also summarize, compare and discuss various models from the past and present for comprehensive understanding and finally provide open problems and possible directions for future research.
基金supported in part by the National Natural Science Foundation of China(62276192)。
文摘Hyperspectral image super-resolution,which refers to reconstructing the high-resolution hyperspectral image from the input low-resolution observation,aims to improve the spatial resolution of the hyperspectral image,which is beneficial for subsequent applications.The development of deep learning has promoted significant progress in hyperspectral image super-resolution,and the powerful expression capabilities of deep neural networks make the predicted results more reliable.Recently,several latest deep learning technologies have made the hyperspectral image super-resolution method explode.However,a comprehensive review and analysis of the latest deep learning methods from the hyperspectral image super-resolution perspective is absent.To this end,in this survey,we first introduce the concept of hyperspectral image super-resolution and classify the methods from the perspectives with or without auxiliary information.Then,we review the learning-based methods in three categories,including single hyperspectral image super-resolution,panchromatic-based hyperspectral image super-resolution,and multispectral-based hyperspectral image super-resolution.Subsequently,we summarize the commonly used hyperspectral dataset,and the evaluations for some representative methods in three categories are performed qualitatively and quantitatively.Moreover,we briefly introduce several typical applications of hyperspectral image super-resolution,including ground object classification,urban change detection,and ecosystem monitoring.Finally,we provide the conclusion and challenges in existing learning-based methods,looking forward to potential future research directions.
基金Project supported by the National Natural Science Foundation of China(No.42202314)。
文摘A coupled thermal-hydro-mechanical cohesive phase-field model for hydraulic fracturing in deep coal seams is presented.Heat exchange between the cold fluid and the hot rock is considered,and the thermal contribution terms between the cold fluid and the hot rock are derived.Heat transfer obeys Fourier's law,and porosity is used to relate the thermodynamic parameters of the fracture and matrix domains.The net pressure difference between the fracture and the matrix is neglected,and thus the fluid flow is modeled by the unified fluid-governing equations.The evolution equations of porosity and Biot's coefficient during hydraulic fracturing are derived from their definitions.The effect of coal cleats is considered and modeled by Voronoi polygons,and this approach is shown to have high accuracy.The accuracy of the proposed model is verified by two sets of fracturing experiments in multilayer coal seams.Subsequently,the differences in fracture morphology,fluid pressure response,and fluid pressure distribution between direct fracturing of coal seams and indirect fracturing of shale interlayers are explored,and the effects of the cluster number and cluster spacing on fracture morphology for multi-cluster fracturing are also examined.The numerical results show that the proposed model is expected to be a powerful tool for the fracturing design and optimization of deep coalbed methane.
基金National Natural Science Foundation of China(No. 42571463)Macao Young Scholars Program(No. AM2023033)+1 种基金Shaanxi Province Youth Science and Technology Star Program(No. 2024ZCKJXX-115)Natural Science Foundation of Shaanxi Province(No.2025JC-YBMS-257)。
文摘Hyper Spectral Image Super-Resolution(HSI-SR) has gained significant attention in recent years due to its potential applications.However,the challenge of obtaining high-resolution hyperspectral images is compounded by limitations in sensor resolution and the high dimensionality of spectral data.Traditional approaches,including interpolation-based methods and sparse representation techniques,often struggle to capture the intricate spectral-spatial dependencies in hyperspectral images.To address these limitations,this study proposes a Hadamard Self-Attention Network(HSAN) for fusing a High-resolution Multispectral Image(Hr-MSI) and a Low-resolution Hyper Spectral Image(Lr-HSI),achieving HSI-SR for obtaining a High-resolution Hyper Spectral Image(Hr-HSI).The core of HSAN is a new Hadamard self-attention mechanism that can be more efficient than traditional dot-product attention because it avoids matrix multiplications and softmax operations.Considering that deep learning-based data fusion typically entails a significant computational and storage burden,this new approach can be integrated with convolutional layers to form an unsupervised lightweight network,which significantly reduces dependence on computational resources.Experimental results across four datasets validate the effectiveness and advantages of HSAN,compared with state-of-the-art approaches.The source code will be available at https://github.com/zxnhkdm/HSAN.
基金the support of Research Program of Fine Exploration and Surrounding Rock Classification Technology for Deep Buried Long Tunnels Driven by Horizontal Directional Drilling and Magnetotelluric Methods Based on Deep Learning under Grant E202408010the Sichuan Science and Technology Program under Grant 2024NSFSC1984 and Grant 2024NSFSC1990。
文摘Porosity is an important attribute for evaluating the petrophysical properties of reservoirs, and has guiding significance for the exploration and development of oil and gas. The seismic inversion is a key method for comprehensively obtaining the porosity. Deep learning methods provide an intelligent approach to suppress the ambiguity of the conventional inversion method. However, under the trace-bytrace inversion strategy, there is a lack of constraints from geological structural information, resulting in poor lateral continuity of prediction results. In addition, the heterogeneity and the sedimentary variability of subsurface media also lead to uncertainty in intelligent prediction. To achieve fine prediction of porosity, we consider the lateral continuity and variability and propose an improved structural modeling deep learning porosity prediction method. First, we combine well data, waveform attributes, and structural information as constraints to model geophysical parameters, constructing a high-quality training dataset with sedimentary facies-controlled significance. Subsequently, we introduce a gated axial attention mechanism to enhance the features of dataset and design a bidirectional closed-loop network system constrained by inversion and forward processes. The constraint coefficient is adaptively adjusted by the petrophysical information contained between the porosity and impedance in the study area. We demonstrate the effectiveness of the adaptive coefficient through numerical experiments.Finally, we compare the performance differences between the proposed method and conventional deep learning methods using data from two study areas. The proposed method achieves better consistency with the logging porosity, demonstrating the superiority of the proposed method.
文摘Significant advancements have been achieved in the field of Single Image Super-Resolution(SISR)through the utilization of Convolutional Neural Networks(CNNs)to attain state-of-the-art performance.Recent efforts have explored the incorporation of Transformers to augment network performance in SISR.However,the high computational cost of Transformers makes them less suitable for deployment on lightweight devices.Moreover,the majority of enhancements for CNNs rely predominantly on small spatial convolutions,thereby neglecting the potential advantages of large kernel convolution.In this paper,the authors propose a Multi-Perception Large Kernel convNet(MPLKN)which delves into the exploration of large kernel convolution.Specifically,the authors have architected a Multi-Perception Large Kernel(MPLK)module aimed at extracting multi-scale features and employ a stepwise feature fusion strategy to seamlessly integrate these features.In addition,to enhance the network's capacity for nonlinear spatial information processing,the authors have designed a Spatial-Channel Gated Feed-forward Network(SCGFN)that is capable of adapting to feature interactions across both spatial and channel dimensions.Experimental results demonstrate that MPLKN outperforms other lightweight image super-resolution models while maintaining a minimal number of parameters and FLOPs.
基金supported by the National Key R&D Program of China(2021YFF0502900)the National Natural Science Foundation of China(61835009/62127819).
文摘The algorithm used for reconstruction or resolution enhancement is one of the factors affectingthe quality of super-resolution images obtained by fluorescence microscopy.Deep-learning-basedalgorithms have achieved stateof-the-art performance in super-resolution fluorescence micros-copy and are becoming increasingly attractive.We firstly introduce commonly-used deep learningmodels,and then review the latest applications in terms of the net work architectures,the trainingdata and the loss functions.Additionally,we discuss the challenges and limits when using deeplearning to analyze the fluorescence microscopic data,and suggest ways to improve the reliability and robustness of deep learning applications.
基金Projects(2024YFC3013801,2022YFC3004602)supported by the National Key R&D Program of ChinaProjects(U23B2093,52034009)supported by the National Natural Science Foundation of China。
文摘Rock residual strength,as an important input parameter,plays an indispensable role in proposing the reasonable and scientific scheme about stope design,underground tunnel excavation and stability evaluation of deep chambers.Therefore,previous residual strength models of rocks established were reviewed.And corresponding related problems were stated.Subsequently,starting from the effects of bedding and whole life-cycle evolution process,series of triaxial mechanical tests of deep bedded sandstone with five bedding angles were conducted under different confining pressures.Then,six residual strength models considering the effects of bedding and whole life-cycle evolution process were established and evaluated.Finally,a cohesion loss model for determining residual strength of deep bedded sandstone was verified.The results showed that the effects of bedding and whole life-cycle evolution process had both significant influences on the evolution characteristic of residual strength of deep bedded sandstone.Additionally,residual strength parameters:residual cohesion and residual internal friction angle of deep bedded sandstone were not constant,which both significantly changed with increasing bedding angle.Besides,the cohesion loss model was the most suitable for determining and estimating the residual strength of bedded rocks,which could provide more accurate theoretical guidance for the stability control of deep chambers.
基金supported by the Project of Stable Support for Youth Team in Basic Research Field,CAS(grant No.YSBR-018)the National Natural Science Foundation of China(grant Nos.42188101,42130204)+4 种基金the B-type Strategic Priority Program of CAS(grant no.XDB41000000)the National Natural Science Foundation of China(NSFC)Distinguished Overseas Young Talents Program,Innovation Program for Quantum Science and Technology(2021ZD0300301)the Open Research Project of Large Research Infrastructures of CAS-“Study on the interaction between low/mid-latitude atmosphere and ionosphere based on the Chinese Meridian Project”.The project was supported also by the National Key Laboratory of Deep Space Exploration(Grant No.NKLDSE2023A002)the Open Fund of Anhui Provincial Key Laboratory of Intelligent Underground Detection(Grant No.APKLIUD23KF01)the China National Space Administration(CNSA)pre-research Project on Civil Aerospace Technologies No.D010305,D010301.
文摘Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 km.Because they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite systems.In this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde observations.The deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular.
文摘Single image super-resolution(SISR)is a fundamentally challenging problem because a low-resolution(LR)image can correspond to a set of high-resolution(HR)images,while most are not expected.Recently,SISR can be achieved by a deep learning-based method.By constructing a very deep super-resolution convolutional neural network(VDSRCNN),the LR images can be improved to HR images.This study mainly achieves two objectives:image super-resolution(ISR)and deblurring the image from VDSRCNN.Firstly,by analyzing ISR,we modify different training parameters to test the performance of VDSRCNN.Secondly,we add the motion blurred images to the training set to optimize the performance of VDSRCNN.Finally,we use image quality indexes to evaluate the difference between the images from classical methods and VDSRCNN.The results indicate that the VDSRCNN performs better in generating HR images from LR images using the optimized VDSRCNN in a proper method.
文摘This paper develops a deep estimator framework of deep convolution networks(DCNs)for super-resolution direction of arrival(DOA)estimation.In addition to the scenario of correlated signals,the quantization errors of the DCN are the major challenge.In our deep estimator framework,one DCN is used for spectrum estimation with quantization errors,and the remaining two DCNs are used to estimate quantization errors.We propose training our estimator using the spatial sampled covariance matrix directly as our deep estimator’s input without any feature extraction operation.Then,we reconstruct the original spatial spectrum from the spectrum estimate and quantization errors estimate.Also,the feasibility of the proposed deep estimator is analyzed in detail in this paper.Once the deep estimator is appropriately trained,it can recover the correlated signals’spatial spectrum fast and accurately.Simulation results show that our estimator performs well in both resolution and estimation error compared with the state-of-the-art algorithms.
基金the National Key Research and Development Program of China(No.2019YFB1405900)。
文摘Image super-resolution(SR)is an important technique for improving the resolution and quality of images.With the great progress of deep learning,image super-resolution achieves remarkable improvements recently.In this work,a brief survey on recent advances of deep learning based single image super-resolution methods is systematically described.The existing studies of SR techniques are roughly grouped into ten major categories.Besides,some other important issues are also introduced,such as publicly available benchmark datasets and performance evaluation metrics.Finally,this survey is concluded by highlighting four future trends.
基金the National Natural Science Foundation(NNSF)of China under Grant 41927801.
文摘The evaluation of adsorption states and shale gas content in shale fractures and pores relies on the analysis of these fractures and pores.Scanning electron microscopy images are commonly used for shale analysis;however,their low resolution,particularly the loss of high-frequency information at pore edges,presents challenges in analyzing fractures and pores in shale gas reservoirs.This study introduced a novel neural network called the spatial-spectral domain attention network(SSDAN),which employed spatial and spectral domain attention mechanisms to extract features and restore information in parallel.The network generated super-resolution images through a fusion module that included CNN-based spatial blocks for pixel-level image information recovery,spectral blocks to process Fourier transform information of images and enhance high-frequency recovery,and an adaptive vision transformer to process Fourier transform block information,eliminating the need for a preset image size.The SSDAN model demonstrated exceptional performance in comparative experiments on marine shale and marine continental shale datasets,achieving optimal performance on key indicators such as peak signal-to-noise ratio,structural similarity,learned perceptual image patch similarity,and Frechet inception distance while also exhibiting superior visual performance in pore recovery.Ablation experiments further confirmed the effectiveness of the spatial blocks,channel attention,spectral blocks,and frequency loss function in the model.The SSDAN model showed remarkable capability in enhancing the resolution of shale gas reservoir images and restoring high-frequency information at pore edges,thereby validating its effectiveness in unconventional natural gas reservoir analyses.
基金supported by the Bill & Melinda Gates Foundation and the Minderoo Foundation
文摘Predicting cross-immunity between viral strains is vital for public health surveillance and vaccine development.Traditional neural network methods,such as BiLSTM,could be ineffective due to the lack of lab data for model training and the overshadowing of crucial features within sequence concatenation.The current work proposes a less data-consuming model incorporating a pre-trained gene sequence model and a mutual information inference operator.Our methodology utilizes gene alignment and deduplication algorithms to preprocess gene sequences,enhancing the model’s capacity to discern and focus on distinctions among input gene pairs.The model,i.e.,DNA Pretrained Cross-Immunity Protection Inference model(DPCIPI),outperforms state-of-theart(SOTA)models in predicting hemagglutination inhibition titer from influenza viral gene sequences only.Improvement in binary cross-immunity prediction is 1.58%in F1,2.34%in precision,1.57%in recall,and 1.57%in Accuracy.For multilevel cross-immunity improvements,the improvement is 2.12%in F1,3.50%in precision,2.19%in recall,and 2.19%in Accuracy.Our study showcases the potential of pre-trained gene models to improve predictions of antigenic variation and cross-immunity.With expanding gene data and advancements in pre-trained models,this approach promises significant impacts on vaccine development and public health.
