Burns are a main cause of accidental injuries among children in China.Because of the unique wound repair capacity and demand for growth in pediatric patients,the management of pediatric deep partial-thickness burn wou...Burns are a main cause of accidental injuries among children in China.Because of the unique wound repair capacity and demand for growth in pediatric patients,the management of pediatric deep partial-thickness burn wounds involves a broader range of treatment options and controversy.We assembled experts from relevant fields in China to reach a consensus on the key points of thermal-induced pediatric deep partial-thickness burn-wound management,including definition and diagnosis,surgical treatments,nonsurgical treatment,choice of wound dressings,growth factor applications,infectious wound treatment,scar prevention and treatment.The committee members hope that the Expert Consensus will provide help and guiding recommendations for the treatment of pediatric deep partial-thickness burn wounds.展开更多
Partial-thickness dermal burn(PTDB)causes devastating trauma to the skin,resulting in an increased risk of infections and scars[1].PTDB studies allow to better understand its pathophysiology and to improve the managem...Partial-thickness dermal burn(PTDB)causes devastating trauma to the skin,resulting in an increased risk of infections and scars[1].PTDB studies allow to better understand its pathophysiology and to improve the management of PDTB lesions[2].展开更多
Objective:To analyse the clinical effect of comprehensive rehabilitation therapy in patients with deep burns at different functional joint areas.Methods:Eighty-one patients with deep burns with different functional jo...Objective:To analyse the clinical effect of comprehensive rehabilitation therapy in patients with deep burns at different functional joint areas.Methods:Eighty-one patients with deep burns with different functional joint areas from April 2018 to April 2019 were divided into the conventional and rehabilitation groupings.The conventional group(n=40)received routine treatment and rehabilitation while the rehabilitation group(n=41)was given comprehensive rehabilitation treatment.Thereafter,the recovery of joint function in patients with deep burns in different areas,the combined value of clinical long-term treatment,the recovery of joint function and the score of daily living ability were calculated.Results:The total long-term effective rate of treatment,the recovery of the joint function,and the score of daily living ability of the patients with deep burns in the rehabilitation group were more favourable than those of the conventional group as demonstrated by P<0.05,the index data indicating statistical significance.Conclusion:Comprehensive rehabilitation therapy can reduce complications and improve the quality of life in patients with deep burns in different functional joint areas.展开更多
Objective: to explore and analyze the clinical effect and significance of deep wound repair in burn surgery. Methods: in this study, 60 burn patients treated in our hospital from February 2020 to February 2022 were se...Objective: to explore and analyze the clinical effect and significance of deep wound repair in burn surgery. Methods: in this study, 60 burn patients treated in our hospital from February 2020 to February 2022 were selected and randomly divided into experimental group and control group, with 30 patients in each group. 30 patients in the experimental group were treated by deep wound repair surgery, while 30 patients in the control group were treated by traditional treatment. The clinical treatment effect between the two groups was analyzed. Results: comparing the clinical treatment effect of two groups of patients, the number of planned reoperation wounds, the average number of operations, wound healing time and hospitalization time in the experimental group were significantly better than those in the control group. Comparing the relevant data between the two groups, the difference was significant (P 0.05), which was statistically significant. The skin flap healing and skin flap healing in the experimental group were also significantly better than those in the control group, and there was a significant difference between the two groups (P 0.05), which was statistically significant. Conclusion: by comparing the data of the two groups of patients, the recovery of the patients in the experimental group treated with deep burn surgery is obviously better than that of the patients in the control group treated with traditional methods. Therefore, the clinical treatment effect of deep burn surgery is ideal, and the wound healing speed of the treated patients is faster, so it is worthy of clinical promotion.展开更多
The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields.Here,we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluron...The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields.Here,we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluronate(HA),Rhein,and Zn^(2+)(denoted as HRZn hydrogel)for enhanced deep burn wound healing.The HRZn hydrogel was readily prepared by directly mixing HA,Rhein,and Zn^(2+)and formed through a synergistic combination of in situ mineralization and dynamic crosslinking processes.Notably,we showed that Zn^(2+)could effectively induce the formation of Rhein nanofibers with the assistance of HA.This unique structure not only strengthened the hydrogel’s mechanical properties,but also endowed the HRZn hydrogel with sustained release ability towards Rhein and Zn^(2+).Leveraging the synergistic effects of Rhein and Zn^(2+),the HRZn hydrogel exhibited potent antimicrobial,anti-inflammatory,and pro-angiogenic properties.In vivo experiments demonstrated its efficacy in promoting the healing of Staphylococcus aureus(S.aureus)-infected deep burn wounds,highlighting its potential as an advanced wound dressing.Overall,this study presents a promising strategy for the development of multifunctional hydrogels tailored for the treatment of complex burn injuries.展开更多
面对气候变化加剧带来的异常与极端火险事件频发,火管理范式正由传统被动控制转向以灾害风险韧性为导向的“与火共存”。自然生态系统中的动植物与传统生态智慧为适应低强度火灾提供了宝贵经验,揭示了可持续共存的潜力。尽管计划烧除是...面对气候变化加剧带来的异常与极端火险事件频发,火管理范式正由传统被动控制转向以灾害风险韧性为导向的“与火共存”。自然生态系统中的动植物与传统生态智慧为适应低强度火灾提供了宝贵经验,揭示了可持续共存的潜力。尽管计划烧除是公认有效的火灾风险管理工具,但在中国具体国情下,“与火共存”的系统化理念及其与计划烧除的整合研究和应用仍显不足。在研究国内外“与火共存”的基础上,创建“灾害风险预测-与火共存能力评估-计划烧除战略优先区(Risk and Coexistence-Prescribed Burning,RCO-PB)”框架。该框架旨在从理论层面系统化梳理火灾风险与生态系统共存能力间的复杂关系,并构建一套面向区域尺度火管理空间优化的普适性方法论。核心目标在于通过此框架,有效降低高强度火灾风险,科学规划火管理优先区,并为维护生物多样性提供适宜的生态环境。在RCO-PB框架指导下,运用机器学习和深度学习模型,对研究区域(重庆市嘉陵江流域)的火灾风险进行精准预测,并对生态系统的与火共存能力进行了深入评估。应用空间优化模型识别并确定了计划烧除的战略优先区,重点关注那些共存能力强但火灾风险高的区域。结果表明:土地覆盖因子在火灾风险模型预测中起到关键作用,研究区内3%的地区极易发生火灾(风险值≥0.659),7%的地区发生火灾的风险很高(风险值≥0.411),北碚缙云山火险等级极高。与火共存能力高价值区集中在植被复杂、茂密的生态系统,合川南部、北碚西部和北部具有较高的共存能力(前10%,值>0.9)。计划烧除优先区分布在以马尾松纯林、针阔混交林(马尾松-青冈栎/香樟等)为主的林区,主要对这些区域的成熟林木以及灌木进行计划烧除处理。该框架为重庆应用计划烧除管理火灾风险提供有利依据,并为我国西南地区面临高强度火灾的山地城市提供了参考。展开更多
Skin is the largest body organ that is prone to the environment mostspecifically. Therefore the skin is susceptible to many damages, including burndamage. Burns can endanger life and are linked to high morbidity and m...Skin is the largest body organ that is prone to the environment mostspecifically. Therefore the skin is susceptible to many damages, including burndamage. Burns can endanger life and are linked to high morbidity and mortalityrates. Effective diagnosis with the help of accurate burn zone and wound depthevaluation is important for clinical efficacy. The following characteristics areassociated with the skin burn wound, such as healing, infection, painand stressand keloid formation. Tissue regeneration also takes a significant amount of timefor formation while considering skin healing after a burn injury. Deep neural networks can automatically assist in the extraction of features from a burn image. Inour approach to burn wound analysis and regeneration of the tissue of the skinburn wound, we use the Faster RCNN (Regional Convolutional Neural Network),which is based on their severity of the burn wound. The success rates of skin curefor burning injuries can be dramatically increased with the use of different skinreplacements. Our objective is to analyze different deep learning techniques thatmay help to analyze and classify burn wounds in a superficial, partial and complete thickness, while treating burn wounds more accurately. The application ofFaster RCNN effectively classifies wound without first degree, second and thirddegree confusion, thus providing a suitable solution to burning wounds. Theadvancement in the field of profound training offers an important path in the fieldof the processing and burning of trauma.展开更多
基金Shanghai Directed Projects of Biopharmaceutical Field(22DX1900600)Shanghai Research Center for Burn and Wound Repair(2023ZZ02013)Shanghai Municipal Key Clinical Specialty of China(shslczdzk02302).
文摘Burns are a main cause of accidental injuries among children in China.Because of the unique wound repair capacity and demand for growth in pediatric patients,the management of pediatric deep partial-thickness burn wounds involves a broader range of treatment options and controversy.We assembled experts from relevant fields in China to reach a consensus on the key points of thermal-induced pediatric deep partial-thickness burn-wound management,including definition and diagnosis,surgical treatments,nonsurgical treatment,choice of wound dressings,growth factor applications,infectious wound treatment,scar prevention and treatment.The committee members hope that the Expert Consensus will provide help and guiding recommendations for the treatment of pediatric deep partial-thickness burn wounds.
基金part of the RHU SUCCESS and supported by ANR 2030supported by NAOS ILS,France.
文摘Partial-thickness dermal burn(PTDB)causes devastating trauma to the skin,resulting in an increased risk of infections and scars[1].PTDB studies allow to better understand its pathophysiology and to improve the management of PDTB lesions[2].
文摘Objective:To analyse the clinical effect of comprehensive rehabilitation therapy in patients with deep burns at different functional joint areas.Methods:Eighty-one patients with deep burns with different functional joint areas from April 2018 to April 2019 were divided into the conventional and rehabilitation groupings.The conventional group(n=40)received routine treatment and rehabilitation while the rehabilitation group(n=41)was given comprehensive rehabilitation treatment.Thereafter,the recovery of joint function in patients with deep burns in different areas,the combined value of clinical long-term treatment,the recovery of joint function and the score of daily living ability were calculated.Results:The total long-term effective rate of treatment,the recovery of the joint function,and the score of daily living ability of the patients with deep burns in the rehabilitation group were more favourable than those of the conventional group as demonstrated by P<0.05,the index data indicating statistical significance.Conclusion:Comprehensive rehabilitation therapy can reduce complications and improve the quality of life in patients with deep burns in different functional joint areas.
文摘Objective: to explore and analyze the clinical effect and significance of deep wound repair in burn surgery. Methods: in this study, 60 burn patients treated in our hospital from February 2020 to February 2022 were selected and randomly divided into experimental group and control group, with 30 patients in each group. 30 patients in the experimental group were treated by deep wound repair surgery, while 30 patients in the control group were treated by traditional treatment. The clinical treatment effect between the two groups was analyzed. Results: comparing the clinical treatment effect of two groups of patients, the number of planned reoperation wounds, the average number of operations, wound healing time and hospitalization time in the experimental group were significantly better than those in the control group. Comparing the relevant data between the two groups, the difference was significant (P 0.05), which was statistically significant. The skin flap healing and skin flap healing in the experimental group were also significantly better than those in the control group, and there was a significant difference between the two groups (P 0.05), which was statistically significant. Conclusion: by comparing the data of the two groups of patients, the recovery of the patients in the experimental group treated with deep burn surgery is obviously better than that of the patients in the control group treated with traditional methods. Therefore, the clinical treatment effect of deep burn surgery is ideal, and the wound healing speed of the treated patients is faster, so it is worthy of clinical promotion.
基金supported by the National Natural Science Foundation of China(Nos.52222307 and 52303214)the Department of Science and Technology of Jilin Province(No.20230204086YY).
文摘The development of advanced wound healing materials for deep burn injuries remains a crucial challenge in biomedical fields.Here,we developed a multifunctional mineralized hydrogel dressing composed of sodium hyaluronate(HA),Rhein,and Zn^(2+)(denoted as HRZn hydrogel)for enhanced deep burn wound healing.The HRZn hydrogel was readily prepared by directly mixing HA,Rhein,and Zn^(2+)and formed through a synergistic combination of in situ mineralization and dynamic crosslinking processes.Notably,we showed that Zn^(2+)could effectively induce the formation of Rhein nanofibers with the assistance of HA.This unique structure not only strengthened the hydrogel’s mechanical properties,but also endowed the HRZn hydrogel with sustained release ability towards Rhein and Zn^(2+).Leveraging the synergistic effects of Rhein and Zn^(2+),the HRZn hydrogel exhibited potent antimicrobial,anti-inflammatory,and pro-angiogenic properties.In vivo experiments demonstrated its efficacy in promoting the healing of Staphylococcus aureus(S.aureus)-infected deep burn wounds,highlighting its potential as an advanced wound dressing.Overall,this study presents a promising strategy for the development of multifunctional hydrogels tailored for the treatment of complex burn injuries.
文摘面对气候变化加剧带来的异常与极端火险事件频发,火管理范式正由传统被动控制转向以灾害风险韧性为导向的“与火共存”。自然生态系统中的动植物与传统生态智慧为适应低强度火灾提供了宝贵经验,揭示了可持续共存的潜力。尽管计划烧除是公认有效的火灾风险管理工具,但在中国具体国情下,“与火共存”的系统化理念及其与计划烧除的整合研究和应用仍显不足。在研究国内外“与火共存”的基础上,创建“灾害风险预测-与火共存能力评估-计划烧除战略优先区(Risk and Coexistence-Prescribed Burning,RCO-PB)”框架。该框架旨在从理论层面系统化梳理火灾风险与生态系统共存能力间的复杂关系,并构建一套面向区域尺度火管理空间优化的普适性方法论。核心目标在于通过此框架,有效降低高强度火灾风险,科学规划火管理优先区,并为维护生物多样性提供适宜的生态环境。在RCO-PB框架指导下,运用机器学习和深度学习模型,对研究区域(重庆市嘉陵江流域)的火灾风险进行精准预测,并对生态系统的与火共存能力进行了深入评估。应用空间优化模型识别并确定了计划烧除的战略优先区,重点关注那些共存能力强但火灾风险高的区域。结果表明:土地覆盖因子在火灾风险模型预测中起到关键作用,研究区内3%的地区极易发生火灾(风险值≥0.659),7%的地区发生火灾的风险很高(风险值≥0.411),北碚缙云山火险等级极高。与火共存能力高价值区集中在植被复杂、茂密的生态系统,合川南部、北碚西部和北部具有较高的共存能力(前10%,值>0.9)。计划烧除优先区分布在以马尾松纯林、针阔混交林(马尾松-青冈栎/香樟等)为主的林区,主要对这些区域的成熟林木以及灌木进行计划烧除处理。该框架为重庆应用计划烧除管理火灾风险提供有利依据,并为我国西南地区面临高强度火灾的山地城市提供了参考。
文摘Skin is the largest body organ that is prone to the environment mostspecifically. Therefore the skin is susceptible to many damages, including burndamage. Burns can endanger life and are linked to high morbidity and mortalityrates. Effective diagnosis with the help of accurate burn zone and wound depthevaluation is important for clinical efficacy. The following characteristics areassociated with the skin burn wound, such as healing, infection, painand stressand keloid formation. Tissue regeneration also takes a significant amount of timefor formation while considering skin healing after a burn injury. Deep neural networks can automatically assist in the extraction of features from a burn image. Inour approach to burn wound analysis and regeneration of the tissue of the skinburn wound, we use the Faster RCNN (Regional Convolutional Neural Network),which is based on their severity of the burn wound. The success rates of skin curefor burning injuries can be dramatically increased with the use of different skinreplacements. Our objective is to analyze different deep learning techniques thatmay help to analyze and classify burn wounds in a superficial, partial and complete thickness, while treating burn wounds more accurately. The application ofFaster RCNN effectively classifies wound without first degree, second and thirddegree confusion, thus providing a suitable solution to burning wounds. Theadvancement in the field of profound training offers an important path in the fieldof the processing and burning of trauma.
