Data on lion skull measurements taken were collected and analyzed to determine trends in trophy size as an indicator of population size, and area of origin among the concessioned hunting areas in Zambia for the period...Data on lion skull measurements taken were collected and analyzed to determine trends in trophy size as an indicator of population size, and area of origin among the concessioned hunting areas in Zambia for the period 1967-2000. A comparison of trophy quality was also made with Tanzania and Zimbabwe which were the other two key sources of lion trophies in Africa. It was assumed that a comprehensive analysis of lion trophy sizes obtained from trophy hunting would be used as an indicator of hunting pressure on lion populations in Zambia. This approach was used because trophy size is an index of abundance particularly for species such as lion which are difficult to count using conventional census methods. Record lion trophies from Safari Club International rating were also collected and assessed to compare trophy quality obtained from Zambia and those of Tanzania and Zimbabwe for the same period 1967-2000 (33 years). Results obtained suggested that Zambia’s contribution to the record trophies under Safari Club International did not decline in the intervening period 1967-2000 and could not be used as an effective indicator of lion population in Zambia. At regional level, Zambia had second highest 24%, after Tanzania 56%, while Zimbabwe was third, 20%. It was found that the size of skulls could not be used as an effective indicator of population size as the record trophies did not decline while the population was alleged to have declined on the continent. Other factors, such as genetic, low prey densities, snaring, poisoning and problem animal control needed to be investigated to determine their impact on the lion population status.展开更多
Current treatments for cerebral amyloid angiopathy are mainly symptomatic and have limited efficacy,and there is a lack of targeted therapies.Mesenchymal stem cell transplantation improves cognitive and motor function...Current treatments for cerebral amyloid angiopathy are mainly symptomatic and have limited efficacy,and there is a lack of targeted therapies.Mesenchymal stem cell transplantation improves cognitive and motor function in conditions such as Alzheimer’s disease,acute ischemic stroke,and Parkinson’s disease.In addition,mesenchymal stem cell therapy modulates the immune system,reduces neuroinflammation,and improves resolution of brain lesions by cells of the macrophage lineage.Cerebral amyloid angiopathy and Alzheimer’s disease share similar pathologic changes involving amyloid-beta deposition,which contributes to the progression of both diseases and exacerbates cognitive deficits through impaired vascular integrity and neuroinflammation.Therefore,we hypothesized that mesenchymal stem cell therapy could also ameliorate the pathological changes seen in cerebral amyloid angiopathy by modulating the immune response.In this study,we show that bone marrow mesenchymal stem cells have a protective effect in a mouse model of cerebral amyloid angiopathy(Tg-SwDI/B).Bone marrow mesenchymal stem cell treatment improved cognitive function,reduced neuroinflammation,and maintained blood-brain barrier integrity in Tg-SwDI/B mice.Mechanistically,bone marrow mesenchymal stem cell treatment enhanced the expulsion of damaged mitochondria from neutrophils via migrasomes,in a process known as mitocytosis,thereby preserving mitochondrial quality within the neutrophils.Mitochondrial damage in neutrophils leads to cellular injury,including the generation of reactive oxygen species and the formation of neutrophil extracellular traps.Neutrophils activate mitocytosis to promote mitochondrial renewal,which further enhances their own clearance by macrophage lineage cells.Our findings demonstrate that bone marrow mesenchymal stem cells are a promising therapeutic candidate for cerebral amyloid angiopathy,as they play a significant role in migrasome-dependent mitochondrial quality control in neutrophils.展开更多
The majority of our daily activities and routines are highly dependent on vision.What we experience as our vision arises from the detection and encoding of visual signals in the retina,which are then interpreted in th...The majority of our daily activities and routines are highly dependent on vision.What we experience as our vision arises from the detection and encoding of visual signals in the retina,which are then interpreted in the brain.This interpretation has the benefit of providing a level of constancy to what we experience as vision but also limits our ability to perceive subtle decline in our own vision.展开更多
Ischemic stroke has a higher survival rate and is more likely to result in cognitive impairment than hemorrhagic stroke.The primary pathological mechanism underlying cognitive impairment involves dysfunction of neural...Ischemic stroke has a higher survival rate and is more likely to result in cognitive impairment than hemorrhagic stroke.The primary pathological mechanism underlying cognitive impairment involves dysfunction of neural circuits and damage to specific brain regions.This review aims to investigate the role of the hippocampus in cognitive impairment following a stroke.A review of the literature suggests that the hippocampus is a metabolically active structure that is easily involved in various metabolic states,such as hypoxia and hypoglycaemia.The functional changes in hippocampal cells associated with poststroke cognitive impairment mainly manifest as neuronal apoptosis,impaired synaptic plasticity,and decreased neurogenesis.The primary pathological mechanism of poststroke cognitive impairment involves a complex cascade of reactions,including neuroinflammatory activation,bursts of oxidative stress,and neuronal apoptosis induced by mitochondrial dysfunction.Interventional drugs for cognitive impairment after cerebral ischemia include neuroprotective drugs,traditional Chinese medicines and their extracts,and stem cell therapies.Many of these drugs have unique advantages,including the inhibition of neuroinflammation,the prevention of apoptosis,and the promotion of neurogenesis.They hold great potential for the prevention and treatment of cognitive impairment following cerebral ischemia.However,most current studies are animal experiments,and relatively few clinical studies exist.In future research,emphasis should be placed on interventions for cognitive impairment following cerebral ischemia.These findings offer novel perspectives for the treatment of cognitive impairment after cerebral ischemia.Finally,the role of hippocampal cell dysfunction in other diseases associated with cognitive decline is briefly discussed.The aim of this review is to provide researchers with a comprehensive overview of the role of the hippocampus in cognitive impairment and its intervention strategies.展开更多
Astrocytes,a major class of glial cells,have emerged as crucial regulators of synaptic function,neuronal homeostasis,and cognitive processes(Cabral-Miranda et al.,2024).These star-shaped cells not only provide structu...Astrocytes,a major class of glial cells,have emerged as crucial regulators of synaptic function,neuronal homeostasis,and cognitive processes(Cabral-Miranda et al.,2024).These star-shaped cells not only provide structural and metabolic support to neurons but also actively participate in modulating synaptic transmission,neurovascular coupling,and inflammatory responses in the brain.展开更多
The innate immune system of the central nervous system(CNS),long viewed as primarily microgliadriven,is now increasingly recognized to include astrocytes as active participants in neuroimmune signaling.Chronic alcohol...The innate immune system of the central nervous system(CNS),long viewed as primarily microgliadriven,is now increasingly recognized to include astrocytes as active participants in neuroimmune signaling.Chronic alcohol exposure trigge rs oxidative stress,glial activation,and sustained inflammation,ultimately contributing to cognitive decline and neuronal injury.展开更多
Aging is a universal biological process characterized by the progressive decline in cellular and tissue function,representing the main risk factor for the development of most chronic human diseases.At the cellular lev...Aging is a universal biological process characterized by the progressive decline in cellular and tissue function,representing the main risk factor for the development of most chronic human diseases.At the cellular level,one hallmark of aging is the accumulation of senescent cells—non-dividing yet metabolically active cells that adopt a unique phenotype,including the senescence-associated secretory phenotype(SASP)(Wang et al.,2024).展开更多
Mounting evidence suggests that circadian rhythm disruption may be linked to the onset and progression of Alzheimer’s disease.However,whether this disruption occurs before the appearance of cognitive symptoms and whe...Mounting evidence suggests that circadian rhythm disruption may be linked to the onset and progression of Alzheimer’s disease.However,whether this disruption occurs before the appearance of cognitive symptoms and whether it drives disease development remain unclear.Understanding the temporal relationship between circadian rhythm dysregulation and early Alzheimer’s disease pathological changes may open up new avenues for disease prevention and intervention.To determine if circadian rhythm disruption precedes cognitive decline,we conducted high-resolution transcriptome analyses of the hippocampus in a 5-month-old mouse model of Alzheimer’s disease and age-matched wild-type control mice at multiple time points over a 24-hour period.While the mouse model of Alzheimer’s disease did not exhibit obvious cognitive symptoms at this stage,the expression of circadian-related genes in the hippocampus exhibited extensive abnormalities.In the control group,2109 genes exhibited rhythmic expression characteristics.In the mouse model of Alzheimer’s disease,a marked proportion of these genes lost their rhythmicity,some genes newly developed rhythmicity,and some maintained rhythmicity but with altered expression patterns.Genes related to neuronal function,including those involved in protein homeostasis regulation,neuroinflammation,and ion homeostasis,showed significant changes in circadian rhythm amplitude and phase,and some completely lost their rhythmicity.These findings point to the following critical early events in Alzheimer’s disease:hippocampal circadian gene disruption occurs before cognitive symptoms emerge,genes related to neuronal function are uniquely susceptible to this early dysregulation,and circadian dysfunction may even precede the pathological changes of Alzheimer’s disease and influence disease onset.This work advances Alzheimer’s disease research by clarifying that circadian disruption is an early pre-symptomatic event,reinforcing the potential of circadian rhythm regulation as a strategy for early intervention of Alzheimer’s disease,and identifying neuronal pathways that may serve as intervention targets.展开更多
Biological aging is a complex physiological process characterized by a decline in tissue function and the loss of cellular capabilities,which increase an individual's risk of various diseases[1].While genetic fact...Biological aging is a complex physiological process characterized by a decline in tissue function and the loss of cellular capabilities,which increase an individual's risk of various diseases[1].While genetic factors and lifestyle are key influences on biological aging,environmental factors also play a significant role.Given the rapid aging of the global population,elucidating the factors that influence biological aging is crucial for promoting healthy aging.展开更多
Current pharmacotherapies for Alzheimer's disease(AD)exhibit constrained transient symptomatic relief without halting underlying neurodegenerative progression.Based on the framework of the amyloid cascade and neur...Current pharmacotherapies for Alzheimer's disease(AD)exhibit constrained transient symptomatic relief without halting underlying neurodegenerative progression.Based on the framework of the amyloid cascade and neurofibrillary tangle hypotheses[1],two FDA-approved antiamyloid monoclonal antibodies(Aβ-mAbs),Kisunla and Lecanemab,have demonstrated efficacy in removing cerebral amyloid buildup,thereby modestly slowing cognitive decline in AD patients[2,3].A 2023 meta-analysis in Neurology demonstrated that anti-amyloid therapies significantly accelerated brain volume loss compared to placebo,with Lecanemab demonstrating 36.4%greater volume reduction and Donanemab 23%.展开更多
With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterati...With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of astrocytes.The microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive function.This article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative diseases.This article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial metabolites.Finally,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s diseases.Our findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.展开更多
Increasing temperatures and severe droughts threaten forest vitality globally.Prediction of forest response to climate change requires knowledge of the spatiotemporal patterns of monthly or seasonal climatic impacts o...Increasing temperatures and severe droughts threaten forest vitality globally.Prediction of forest response to climate change requires knowledge of the spatiotemporal patterns of monthly or seasonal climatic impacts on the growth of tree species,likely driven by local climatic aridity,climate trends,edaphic conditions,and the climatic adaption of tree species.The ability of tree species to cope with changing climate and the effects of environmental variables on growth trends and growth-climate relationships across diverse bioclimatic regions are still poorly understood for many species.This study investigated radial growth trends,interannual growth variability,and growth-climate sensitivity of two dominant tree species,Pinus tabulaeformis(PT)and Pinus sylvestris var.mongolica(PS),across a broad climatic gradient with a variety of soil properties in temperate Northern China.Using a network of 83 tree ring chronologies(54 for PT and 29 for PS)from 1971 to 2010,we documented that both species maintained constant growth trends at wet sites,while both displayed rapid declines at dry sites.We reported the species-specific drivers of spatial heterogeneity in growth trends,interannual growth variability,and growth-climate relationships.Calculated climatic variables and soil properties were identified as the most critical factors affecting the growth trends and growth-climate relationships.However,climatic variables play more essential roles than soil properties in determining the spatial heterogeneity of the growth-climate relationship.Lower clay content and higher soil nutrient regimes can exacerbate the moisture-related susceptibility of tree growth.Our findings highlight that soil properties emerged as important modulating factors to predict the drought vulnerability of forests in addition to climatic variables.Considering the continued climate warmingdrying trend in the future,both pines will face a more severe growth decline and increase in drought vulnerability at drier sites with lower clayed soil or higher nutrient regimes.展开更多
1.Background When searching for the term“muscle power”on Google Scholar,about 3.7 million hits come up in 60 ms,and for the past 3 years,there were approximately 225 yearly peer-reviewed publications dealing with mu...1.Background When searching for the term“muscle power”on Google Scholar,about 3.7 million hits come up in 60 ms,and for the past 3 years,there were approximately 225 yearly peer-reviewed publications dealing with muscle power.Muscle power has been used to assess and predict athletic performance,to determine muscle rehabilitation following injury or disease,to measure functional decline as occurs in aging,and many other topics.展开更多
Rarer dementias are associated with atypical symptoms and younger onset,which result in a higher burden of care.We provide a review of the global literature on longitudinal decline in activities of daily living(ADLs)i...Rarer dementias are associated with atypical symptoms and younger onset,which result in a higher burden of care.We provide a review of the global literature on longitudinal decline in activities of daily living(ADLs)in dementias that account for less than 10%of dementia diagnoses.Published studies were identified through searches conducted in Medical Literature Analysis and Retrieval System Online(MEDLINE),Excerpta Medica Database(Embase),Excerpta Medica Care(Emcare),PsycINFO,and Cumulative Index in Nursing and Allied Health Literature(CINAHL).The search criteria included terms related to‘rarer dementias’,‘activities of daily living’and‘longitudinal or cross-sectional studies’following a predefined protocol registered.Studies were screened,and those that met the criteria were citation searched.Quality assessments were performed,and relevant data were extracted.20 articles were selected,of which 19 focused on dementias within the frontotemporal dementia/primary progressive aphasia spectrum,while one addressed posterior cortical atrophy.Four studies were cross-sectional and 16 studies were longitudinal,with a median duration of 2.2 years.The Disability Assessment for Dementia was used to measure decline in 8 of the 20 studies.The varied sequences of ADL decline reported in the literature reflect variation in diagnostic specificity between studies and within-syndrome heterogeneity.Most studies used Alzheimer’s disease staging scales to measure decline,which cannot capture variant-specific symptoms.To enhance care provision in dementia,ADL scales could be deployed postdiagnosis to aid treatment and planning.This necessitates staging scales that are variant-specific and span the disease course from diagnosis to end of life.展开更多
In January and February of 2025,China's textile and clothing exports totaled 42.88 billion US dollars,marking a 4.5%decrease compared to the same period in the previous year.The primary factors contributing to thi...In January and February of 2025,China's textile and clothing exports totaled 42.88 billion US dollars,marking a 4.5%decrease compared to the same period in the previous year.The primary factors contributing to this decline are as follows:First,China’s textile and clothing exports nearly reached USD 45 billion in January and February of 2024,setting a high base.Second,in order to avoid tariffs imposed by the United States,enterprises generally concentrated their exports at the end of last year and January this year.展开更多
Objective:As the prevalence of chronic diseases among the elderly increases year by year,chronic renal insufficiency caused by hypertension has become a hot issue of concern to society and even the world.Methods:This ...Objective:As the prevalence of chronic diseases among the elderly increases year by year,chronic renal insufficiency caused by hypertension has become a hot issue of concern to society and even the world.Methods:This article conducted a retrospective analysis of 1856 elderly people over 65 years old,with a follow-up time of 6 years.The aim is to compare the decline in estimated glomerular filtration rate(EGFR)between hypertensive and non-hypertensive populations under non-intervention conditions,and to explore the impact of blood pressure on EGFR in the elderly.Results:The incidence of hypertension among the elderly in this region is significantly higher than the national level.The EGFR value of hypertensive patients is significantly lower than that of non-hypertensive people.There is a difference in the percentage decline in EGFR between hypertensive and non-hypertensive populations under non-intervention conditions,with hypertensive patients experiencing a higher rate of EGFR decline.When blood pressure is lower than 120/80 mmHg,the EGFR decline ratio is lower compared to when blood pressure is higher than 120/80 mmHg.Conclusion:Lowering blood pressure can effectively slow down the decline of EGFR,and the prevalence of hypertension should be reduced.展开更多
Global climate change has caused range shifts and population declines in various species.However,causal evidence from manipulative studies,particularly for vertebrates,remains scarce.Prolonged temperature increases,a ...Global climate change has caused range shifts and population declines in various species.However,causal evidence from manipulative studies,particularly for vertebrates,remains scarce.Prolonged temperature increases,a direct consequence of climate change,pose significant challenges to species adaptation and survival.We examined the effects of prolonged temperature increases on reproduction,physiology,and behavior adaption in the greater long-tailed hamster using semi-natural enclosures where temperature was manipulated via plastic roofs and windows,creating a greenhouse effect without affecting rainfall.We analyzed data using grouped enclosures(low temperature,LT;high temperature,HT),which showed that prolonged temperature increases led to reduced reproductivity per capita during the breeding season.In addition,prolonged temperature increases reduced night-time activity in founder hamsters during overwintering,increased burrow depth during the breeding season,and raised testicular weights in founder males during the overwintering season.Our study provides experimental evidence that prolonged temperature increases negatively impact population growth of greater long-tailed hamsters by inducing temperature stress and impairing reproductive performance,highlighting the need to address heat stress in wildlife management under climate warming.展开更多
Forest ecosystems are critical to ecological stability,yet their functionality is increasingly threatened by the growing frequency of drought,particularly in arid and semi-arid regions.While afforestation enhances for...Forest ecosystems are critical to ecological stability,yet their functionality is increasingly threatened by the growing frequency of drought,particularly in arid and semi-arid regions.While afforestation enhances forest cover in these areas,the capacity of planted forests to adapt to climate change is poorly understood.This study examines the drought resistance and adaptive capacity of planted and naturally growing Schrenk spruce(Picea schrenkiana Fisch.&C.A.Mey.)in the Ili River Basin,Xinjiang,China using tree-ring analysis.The results indicate that natural stands have a stronger correlation with meteorological factors than plantations.Over the past 50 years,significant growth declines occurred during 1995-1997,2007-2009,and 2012-2014,with natural forests showing a greater frequency and severity of declines compared to plantations.Planted stands demonstrated greater resistance to drought,whereas natural forests had higher resilience and recovery.Over time,natural forests have shown declining resistance to drought but increased resilience and recovery.Conversely,plantations showed declines in resistance and recovery but an increased capacity for recovery.Older natural forests are more prone to growth decline,while structurally simpler planted forests show stronger drought resistance.However,following periods of drought,natural forests demonstrated a stronger capacity for recovery.These findings provide valuable insights into the response of P.schrenkiana to climate change and offer support for the sustainable management and conservation of forest ecosystems in the Xinjiang region of China.展开更多
In the third quarter of 2025,the orders index for textile machinery-compiled by ACIMIT's Economics Department(the Association of Italian Textile Machinery Manufacturers)-recorded a16%decrease compared to the same ...In the third quarter of 2025,the orders index for textile machinery-compiled by ACIMIT's Economics Department(the Association of Italian Textile Machinery Manufacturers)-recorded a16%decrease compared to the same period in 2024.In absolute terms,the index stood at 41.8 points(base year2021=100).The decline reflects negative performances in both the domestic and foreign markets.Specifically,on the domestic market,orders fell by 17%compared to the same quarter of the previous year,with the absolute index value reaching49.9points.展开更多
文摘Data on lion skull measurements taken were collected and analyzed to determine trends in trophy size as an indicator of population size, and area of origin among the concessioned hunting areas in Zambia for the period 1967-2000. A comparison of trophy quality was also made with Tanzania and Zimbabwe which were the other two key sources of lion trophies in Africa. It was assumed that a comprehensive analysis of lion trophy sizes obtained from trophy hunting would be used as an indicator of hunting pressure on lion populations in Zambia. This approach was used because trophy size is an index of abundance particularly for species such as lion which are difficult to count using conventional census methods. Record lion trophies from Safari Club International rating were also collected and assessed to compare trophy quality obtained from Zambia and those of Tanzania and Zimbabwe for the same period 1967-2000 (33 years). Results obtained suggested that Zambia’s contribution to the record trophies under Safari Club International did not decline in the intervening period 1967-2000 and could not be used as an effective indicator of lion population in Zambia. At regional level, Zambia had second highest 24%, after Tanzania 56%, while Zimbabwe was third, 20%. It was found that the size of skulls could not be used as an effective indicator of population size as the record trophies did not decline while the population was alleged to have declined on the continent. Other factors, such as genetic, low prey densities, snaring, poisoning and problem animal control needed to be investigated to determine their impact on the lion population status.
基金Guangdong Basic and Applied Basic Research Foundation,No.2023A1515110543(to XK)National Natural Science Foundation of China,Nos.82471335 and 82171307(to ZL)+3 种基金Noncommunicable Chronic Diseases-National Science and Technology Major Project,No.2023ZD0504803(to ZL)Science and Technology Program of Guangzhou,No.202201020588(to ZL)China Postdoctoral Science Foundation,No.2023M744023(to MH)Guangzhou Municipal School(Hospital)Joint Funding(Dengfeng Hospital)Municipal Key Laboratory Construction Project,No.202102010009(to ZL).
文摘Current treatments for cerebral amyloid angiopathy are mainly symptomatic and have limited efficacy,and there is a lack of targeted therapies.Mesenchymal stem cell transplantation improves cognitive and motor function in conditions such as Alzheimer’s disease,acute ischemic stroke,and Parkinson’s disease.In addition,mesenchymal stem cell therapy modulates the immune system,reduces neuroinflammation,and improves resolution of brain lesions by cells of the macrophage lineage.Cerebral amyloid angiopathy and Alzheimer’s disease share similar pathologic changes involving amyloid-beta deposition,which contributes to the progression of both diseases and exacerbates cognitive deficits through impaired vascular integrity and neuroinflammation.Therefore,we hypothesized that mesenchymal stem cell therapy could also ameliorate the pathological changes seen in cerebral amyloid angiopathy by modulating the immune response.In this study,we show that bone marrow mesenchymal stem cells have a protective effect in a mouse model of cerebral amyloid angiopathy(Tg-SwDI/B).Bone marrow mesenchymal stem cell treatment improved cognitive function,reduced neuroinflammation,and maintained blood-brain barrier integrity in Tg-SwDI/B mice.Mechanistically,bone marrow mesenchymal stem cell treatment enhanced the expulsion of damaged mitochondria from neutrophils via migrasomes,in a process known as mitocytosis,thereby preserving mitochondrial quality within the neutrophils.Mitochondrial damage in neutrophils leads to cellular injury,including the generation of reactive oxygen species and the formation of neutrophil extracellular traps.Neutrophils activate mitocytosis to promote mitochondrial renewal,which further enhances their own clearance by macrophage lineage cells.Our findings demonstrate that bone marrow mesenchymal stem cells are a promising therapeutic candidate for cerebral amyloid angiopathy,as they play a significant role in migrasome-dependent mitochondrial quality control in neutrophils.
基金supported by Vetenskapsrådet 2022-00799 and the Ulla and Ingemar Dahlberg Foundation(to PAW).
文摘The majority of our daily activities and routines are highly dependent on vision.What we experience as our vision arises from the detection and encoding of visual signals in the retina,which are then interpreted in the brain.This interpretation has the benefit of providing a level of constancy to what we experience as vision but also limits our ability to perceive subtle decline in our own vision.
基金supported by Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.KYCX25_3785(to JY).
文摘Ischemic stroke has a higher survival rate and is more likely to result in cognitive impairment than hemorrhagic stroke.The primary pathological mechanism underlying cognitive impairment involves dysfunction of neural circuits and damage to specific brain regions.This review aims to investigate the role of the hippocampus in cognitive impairment following a stroke.A review of the literature suggests that the hippocampus is a metabolically active structure that is easily involved in various metabolic states,such as hypoxia and hypoglycaemia.The functional changes in hippocampal cells associated with poststroke cognitive impairment mainly manifest as neuronal apoptosis,impaired synaptic plasticity,and decreased neurogenesis.The primary pathological mechanism of poststroke cognitive impairment involves a complex cascade of reactions,including neuroinflammatory activation,bursts of oxidative stress,and neuronal apoptosis induced by mitochondrial dysfunction.Interventional drugs for cognitive impairment after cerebral ischemia include neuroprotective drugs,traditional Chinese medicines and their extracts,and stem cell therapies.Many of these drugs have unique advantages,including the inhibition of neuroinflammation,the prevention of apoptosis,and the promotion of neurogenesis.They hold great potential for the prevention and treatment of cognitive impairment following cerebral ischemia.However,most current studies are animal experiments,and relatively few clinical studies exist.In future research,emphasis should be placed on interventions for cognitive impairment following cerebral ischemia.These findings offer novel perspectives for the treatment of cognitive impairment after cerebral ischemia.Finally,the role of hippocampal cell dysfunction in other diseases associated with cognitive decline is briefly discussed.The aim of this review is to provide researchers with a comprehensive overview of the role of the hippocampus in cognitive impairment and its intervention strategies.
文摘Astrocytes,a major class of glial cells,have emerged as crucial regulators of synaptic function,neuronal homeostasis,and cognitive processes(Cabral-Miranda et al.,2024).These star-shaped cells not only provide structural and metabolic support to neurons but also actively participate in modulating synaptic transmission,neurovascular coupling,and inflammatory responses in the brain.
基金supported by startup funding from UNMC to Dr.PPpartially by the National Institute on Alcohol Abuse and Alcoholism (AA031444 and P50AA030407-5126,Pilot Core grant) to Dr.SS
文摘The innate immune system of the central nervous system(CNS),long viewed as primarily microgliadriven,is now increasingly recognized to include astrocytes as active participants in neuroimmune signaling.Chronic alcohol exposure trigge rs oxidative stress,glial activation,and sustained inflammation,ultimately contributing to cognitive decline and neuronal injury.
基金NIH NIA1RO1AG061879 and 5PO1AG066591(to LME)FONDAP Program 15150012,ECOS-A NID(ECOS230034)the US Army Medical Research Acquisition Activity(USAMRAA)AL2201415(to CH)。
文摘Aging is a universal biological process characterized by the progressive decline in cellular and tissue function,representing the main risk factor for the development of most chronic human diseases.At the cellular level,one hallmark of aging is the accumulation of senescent cells—non-dividing yet metabolically active cells that adopt a unique phenotype,including the senescence-associated secretory phenotype(SASP)(Wang et al.,2024).
基金Shenzhen Science Technology and Innovation Commission,No.JCYJ20220531100811026Shenzhen Clinical Research Center for Trauma Treatment,No.LCYSSQ20220823091405012(both to YZ)Shenzhen Science and Technology Program,No.KQTD20240729102249044.
文摘Mounting evidence suggests that circadian rhythm disruption may be linked to the onset and progression of Alzheimer’s disease.However,whether this disruption occurs before the appearance of cognitive symptoms and whether it drives disease development remain unclear.Understanding the temporal relationship between circadian rhythm dysregulation and early Alzheimer’s disease pathological changes may open up new avenues for disease prevention and intervention.To determine if circadian rhythm disruption precedes cognitive decline,we conducted high-resolution transcriptome analyses of the hippocampus in a 5-month-old mouse model of Alzheimer’s disease and age-matched wild-type control mice at multiple time points over a 24-hour period.While the mouse model of Alzheimer’s disease did not exhibit obvious cognitive symptoms at this stage,the expression of circadian-related genes in the hippocampus exhibited extensive abnormalities.In the control group,2109 genes exhibited rhythmic expression characteristics.In the mouse model of Alzheimer’s disease,a marked proportion of these genes lost their rhythmicity,some genes newly developed rhythmicity,and some maintained rhythmicity but with altered expression patterns.Genes related to neuronal function,including those involved in protein homeostasis regulation,neuroinflammation,and ion homeostasis,showed significant changes in circadian rhythm amplitude and phase,and some completely lost their rhythmicity.These findings point to the following critical early events in Alzheimer’s disease:hippocampal circadian gene disruption occurs before cognitive symptoms emerge,genes related to neuronal function are uniquely susceptible to this early dysregulation,and circadian dysfunction may even precede the pathological changes of Alzheimer’s disease and influence disease onset.This work advances Alzheimer’s disease research by clarifying that circadian disruption is an early pre-symptomatic event,reinforcing the potential of circadian rhythm regulation as a strategy for early intervention of Alzheimer’s disease,and identifying neuronal pathways that may serve as intervention targets.
基金support from the Shenzhen Science and Technology program(grant number 202208183000115)。
文摘Biological aging is a complex physiological process characterized by a decline in tissue function and the loss of cellular capabilities,which increase an individual's risk of various diseases[1].While genetic factors and lifestyle are key influences on biological aging,environmental factors also play a significant role.Given the rapid aging of the global population,elucidating the factors that influence biological aging is crucial for promoting healthy aging.
基金supported by the Research Personnel Cultivation Programme of Zhongda Hospital Southeast(CZXM-GSP-RC172)the Science and Technology Innovation 2030 Major Projects(2022ZD0211600)the National Natural Science Foundation of China(82271574 and 82502335).
文摘Current pharmacotherapies for Alzheimer's disease(AD)exhibit constrained transient symptomatic relief without halting underlying neurodegenerative progression.Based on the framework of the amyloid cascade and neurofibrillary tangle hypotheses[1],two FDA-approved antiamyloid monoclonal antibodies(Aβ-mAbs),Kisunla and Lecanemab,have demonstrated efficacy in removing cerebral amyloid buildup,thereby modestly slowing cognitive decline in AD patients[2,3].A 2023 meta-analysis in Neurology demonstrated that anti-amyloid therapies significantly accelerated brain volume loss compared to placebo,with Lecanemab demonstrating 36.4%greater volume reduction and Donanemab 23%.
基金supported by the Haihe Laboratory of Cell Ecosystem Innovation Foundation,No.22HHXBSS00047(to PL)Graduate Science and Technology Innovation Project of Tianjin,No.2022BKY173(to LZ)Tianjin Municipal Science and Technology Bureau Foundation,No.20201194(to PL).
文摘With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of astrocytes.The microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive function.This article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative diseases.This article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial metabolites.Finally,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s diseases.Our findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.
基金funded by the National Key Research and Development Plan of China(No.2022YFE0127900)the National Natural Science Foundation of China(Nos.32071558,32171559)+2 种基金the Natural Science Foundation Key Project of Inner Mongolia Autonomous Region,China(No.2023ZD23)the Hulunbuir Science and Technology Plan Project(No.SF2022001)the Fundamental Research Funds of CAF(CAFYBB2023ZA002).
文摘Increasing temperatures and severe droughts threaten forest vitality globally.Prediction of forest response to climate change requires knowledge of the spatiotemporal patterns of monthly or seasonal climatic impacts on the growth of tree species,likely driven by local climatic aridity,climate trends,edaphic conditions,and the climatic adaption of tree species.The ability of tree species to cope with changing climate and the effects of environmental variables on growth trends and growth-climate relationships across diverse bioclimatic regions are still poorly understood for many species.This study investigated radial growth trends,interannual growth variability,and growth-climate sensitivity of two dominant tree species,Pinus tabulaeformis(PT)and Pinus sylvestris var.mongolica(PS),across a broad climatic gradient with a variety of soil properties in temperate Northern China.Using a network of 83 tree ring chronologies(54 for PT and 29 for PS)from 1971 to 2010,we documented that both species maintained constant growth trends at wet sites,while both displayed rapid declines at dry sites.We reported the species-specific drivers of spatial heterogeneity in growth trends,interannual growth variability,and growth-climate relationships.Calculated climatic variables and soil properties were identified as the most critical factors affecting the growth trends and growth-climate relationships.However,climatic variables play more essential roles than soil properties in determining the spatial heterogeneity of the growth-climate relationship.Lower clay content and higher soil nutrient regimes can exacerbate the moisture-related susceptibility of tree growth.Our findings highlight that soil properties emerged as important modulating factors to predict the drought vulnerability of forests in addition to climatic variables.Considering the continued climate warmingdrying trend in the future,both pines will face a more severe growth decline and increase in drought vulnerability at drier sites with lower clayed soil or higher nutrient regimes.
文摘1.Background When searching for the term“muscle power”on Google Scholar,about 3.7 million hits come up in 60 ms,and for the past 3 years,there were approximately 225 yearly peer-reviewed publications dealing with muscle power.Muscle power has been used to assess and predict athletic performance,to determine muscle rehabilitation following injury or disease,to measure functional decline as occurs in aging,and many other topics.
基金supported by UKResearch and Innovation(MR/S03546X/1)National BrainAppeal,Economic and Social ResearchCouncil(ES/S010467/1)+4 种基金Wellcome Trust(221915/Z/20/Z),ESRC(ES/W006014/1)Royal National Institute for Deaf People-Dunhill Medical Trust Pauline Ashley(204841/Z/16/Z,PA23)London Hospitals Biomedical Research Centre(221915/Z/20/Z)Bloomsbury and East London Doctoral Training Partnership(ES/P000592/1)National Institute for Health Research.
文摘Rarer dementias are associated with atypical symptoms and younger onset,which result in a higher burden of care.We provide a review of the global literature on longitudinal decline in activities of daily living(ADLs)in dementias that account for less than 10%of dementia diagnoses.Published studies were identified through searches conducted in Medical Literature Analysis and Retrieval System Online(MEDLINE),Excerpta Medica Database(Embase),Excerpta Medica Care(Emcare),PsycINFO,and Cumulative Index in Nursing and Allied Health Literature(CINAHL).The search criteria included terms related to‘rarer dementias’,‘activities of daily living’and‘longitudinal or cross-sectional studies’following a predefined protocol registered.Studies were screened,and those that met the criteria were citation searched.Quality assessments were performed,and relevant data were extracted.20 articles were selected,of which 19 focused on dementias within the frontotemporal dementia/primary progressive aphasia spectrum,while one addressed posterior cortical atrophy.Four studies were cross-sectional and 16 studies were longitudinal,with a median duration of 2.2 years.The Disability Assessment for Dementia was used to measure decline in 8 of the 20 studies.The varied sequences of ADL decline reported in the literature reflect variation in diagnostic specificity between studies and within-syndrome heterogeneity.Most studies used Alzheimer’s disease staging scales to measure decline,which cannot capture variant-specific symptoms.To enhance care provision in dementia,ADL scales could be deployed postdiagnosis to aid treatment and planning.This necessitates staging scales that are variant-specific and span the disease course from diagnosis to end of life.
文摘In January and February of 2025,China's textile and clothing exports totaled 42.88 billion US dollars,marking a 4.5%decrease compared to the same period in the previous year.The primary factors contributing to this decline are as follows:First,China’s textile and clothing exports nearly reached USD 45 billion in January and February of 2024,setting a high base.Second,in order to avoid tariffs imposed by the United States,enterprises generally concentrated their exports at the end of last year and January this year.
基金“Clinical Research on Chronic Disease Screening and Therapeutic Guidance for Elderly People Over 60 Years Old”Kunming Science and Technology Plan Project(Project No.:2017-1-S-15382)。
文摘Objective:As the prevalence of chronic diseases among the elderly increases year by year,chronic renal insufficiency caused by hypertension has become a hot issue of concern to society and even the world.Methods:This article conducted a retrospective analysis of 1856 elderly people over 65 years old,with a follow-up time of 6 years.The aim is to compare the decline in estimated glomerular filtration rate(EGFR)between hypertensive and non-hypertensive populations under non-intervention conditions,and to explore the impact of blood pressure on EGFR in the elderly.Results:The incidence of hypertension among the elderly in this region is significantly higher than the national level.The EGFR value of hypertensive patients is significantly lower than that of non-hypertensive people.There is a difference in the percentage decline in EGFR between hypertensive and non-hypertensive populations under non-intervention conditions,with hypertensive patients experiencing a higher rate of EGFR decline.When blood pressure is lower than 120/80 mmHg,the EGFR decline ratio is lower compared to when blood pressure is higher than 120/80 mmHg.Conclusion:Lowering blood pressure can effectively slow down the decline of EGFR,and the prevalence of hypertension should be reduced.
基金supported by the following grants:Major Program of the National Natural Science Foundation of China(Grant 32090021)Young Scientists Fund of the National Natural Science Foundation of China(Grant 32101259)+1 种基金Young Elite Scientists Sponsorship Program by CAST and ISZS(2020-2022QNRC001,ISZS-YESS Program)Chinese Academy of Science projects(Grant ANSO-CR-KP-2020-08).
文摘Global climate change has caused range shifts and population declines in various species.However,causal evidence from manipulative studies,particularly for vertebrates,remains scarce.Prolonged temperature increases,a direct consequence of climate change,pose significant challenges to species adaptation and survival.We examined the effects of prolonged temperature increases on reproduction,physiology,and behavior adaption in the greater long-tailed hamster using semi-natural enclosures where temperature was manipulated via plastic roofs and windows,creating a greenhouse effect without affecting rainfall.We analyzed data using grouped enclosures(low temperature,LT;high temperature,HT),which showed that prolonged temperature increases led to reduced reproductivity per capita during the breeding season.In addition,prolonged temperature increases reduced night-time activity in founder hamsters during overwintering,increased burrow depth during the breeding season,and raised testicular weights in founder males during the overwintering season.Our study provides experimental evidence that prolonged temperature increases negatively impact population growth of greater long-tailed hamsters by inducing temperature stress and impairing reproductive performance,highlighting the need to address heat stress in wildlife management under climate warming.
基金supported by the Tianshan Talent Program of Xinjiang(2022TSYCCX0003,2024TSYCCX0041)the National Natural Science Foundation of China(42375054)+1 种基金the Desert Meteorological Science Research Foundation of China(Sqj2021018)the Young Meteorological Talent Program of China Meteorological Administration and Youth Innovation Team of China Meteorological Administration(CMA2023QN08)。
文摘Forest ecosystems are critical to ecological stability,yet their functionality is increasingly threatened by the growing frequency of drought,particularly in arid and semi-arid regions.While afforestation enhances forest cover in these areas,the capacity of planted forests to adapt to climate change is poorly understood.This study examines the drought resistance and adaptive capacity of planted and naturally growing Schrenk spruce(Picea schrenkiana Fisch.&C.A.Mey.)in the Ili River Basin,Xinjiang,China using tree-ring analysis.The results indicate that natural stands have a stronger correlation with meteorological factors than plantations.Over the past 50 years,significant growth declines occurred during 1995-1997,2007-2009,and 2012-2014,with natural forests showing a greater frequency and severity of declines compared to plantations.Planted stands demonstrated greater resistance to drought,whereas natural forests had higher resilience and recovery.Over time,natural forests have shown declining resistance to drought but increased resilience and recovery.Conversely,plantations showed declines in resistance and recovery but an increased capacity for recovery.Older natural forests are more prone to growth decline,while structurally simpler planted forests show stronger drought resistance.However,following periods of drought,natural forests demonstrated a stronger capacity for recovery.These findings provide valuable insights into the response of P.schrenkiana to climate change and offer support for the sustainable management and conservation of forest ecosystems in the Xinjiang region of China.
文摘In the third quarter of 2025,the orders index for textile machinery-compiled by ACIMIT's Economics Department(the Association of Italian Textile Machinery Manufacturers)-recorded a16%decrease compared to the same period in 2024.In absolute terms,the index stood at 41.8 points(base year2021=100).The decline reflects negative performances in both the domestic and foreign markets.Specifically,on the domestic market,orders fell by 17%compared to the same quarter of the previous year,with the absolute index value reaching49.9points.
