The secondary motor cortex(M2)encodes choice-related information and plays an important role in cue-guided actions.M2 neurons innervate the dorsal striatum(DS),which also contributes to decision-making behavior,yet ho...The secondary motor cortex(M2)encodes choice-related information and plays an important role in cue-guided actions.M2 neurons innervate the dorsal striatum(DS),which also contributes to decision-making behavior,yet how M2 modulates signals in the DS to influence perceptual decision-making is unclear.Using mice performing a visual Go/No-Go task,we showed that inactivating M2 projections to the DS impaired performance by increasing the false alarm(FA)rate to the reward-irrelevant No-Go stimulus.The choice signal of M2 neurons correlated with behavioral performance,and the inactivation of M2 neurons projecting to the DS reduced the choice signal in the DS.By measuring and manipulating the responses of direct or indirect pathway striatal neurons defined by M2 inputs,we found that the indirect pathway neurons exhibited a shorter response latency to the No-Go stimulus,and inactivating their early responses increased the FA rate.These results demonstrate that the M2-to-DS pathway is crucial for suppressing inappropriate responses in perceptual decision behavior.展开更多
Based on the status quantity of water resources in Xi′an region, a commentary on many math models is given for water resources operation and management, and the visual model is provided to solve practical problems. ...Based on the status quantity of water resources in Xi′an region, a commentary on many math models is given for water resources operation and management, and the visual model is provided to solve practical problems. In this model, the information for decision is visible in GIS (Geographic Information Systems) and topological figures. With object orientation methods, the objects are described in proprieties, methods, relations and time periods. The simulation process of the model is developed with Delphi and MapInfo, and the real decision scheme could be examined and practice decision process can be simulated from which. Decision analysis conducted from visual conditions is believable. The exploration to visual model is a beginning of practice research, much more study of which still needs to do.展开更多
基金This work was supported by the STI2030-Major Projects(2021ZD0203700/2021ZD0203703)the National Natural Science Foundation of China(31771151,32171030,and 32100829),the Lingang Lab(LG202104-01-03)+1 种基金Shanghai Municipal Science and Technology Major Project(2018SHZDZX05)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32010200).
文摘The secondary motor cortex(M2)encodes choice-related information and plays an important role in cue-guided actions.M2 neurons innervate the dorsal striatum(DS),which also contributes to decision-making behavior,yet how M2 modulates signals in the DS to influence perceptual decision-making is unclear.Using mice performing a visual Go/No-Go task,we showed that inactivating M2 projections to the DS impaired performance by increasing the false alarm(FA)rate to the reward-irrelevant No-Go stimulus.The choice signal of M2 neurons correlated with behavioral performance,and the inactivation of M2 neurons projecting to the DS reduced the choice signal in the DS.By measuring and manipulating the responses of direct or indirect pathway striatal neurons defined by M2 inputs,we found that the indirect pathway neurons exhibited a shorter response latency to the No-Go stimulus,and inactivating their early responses increased the FA rate.These results demonstrate that the M2-to-DS pathway is crucial for suppressing inappropriate responses in perceptual decision behavior.
基金″Ninth-Five-Year Plan″for Science and Technology in China(95 /91 2 /0 5 /0 2 )
文摘Based on the status quantity of water resources in Xi′an region, a commentary on many math models is given for water resources operation and management, and the visual model is provided to solve practical problems. In this model, the information for decision is visible in GIS (Geographic Information Systems) and topological figures. With object orientation methods, the objects are described in proprieties, methods, relations and time periods. The simulation process of the model is developed with Delphi and MapInfo, and the real decision scheme could be examined and practice decision process can be simulated from which. Decision analysis conducted from visual conditions is believable. The exploration to visual model is a beginning of practice research, much more study of which still needs to do.
