The periosteum generally refers to the outer layer of bone,a specialized tissue primarily composed of fibroblasts and concentrically arranged typeⅠcollagen fibers that also serves as a reservoir for periosteal stem c...The periosteum generally refers to the outer layer of bone,a specialized tissue primarily composed of fibroblasts and concentrically arranged typeⅠcollagen fibers that also serves as a reservoir for periosteal stem cells(Debnath et al.,2018).During physiological bone formation,periosteal stem cells contribute to osteogenesis via the intramembranous pathway,involving cell proliferation and osteogenic differentiation.Following bone damage,however,periosteal stem cells first differentiate into chondrocytes to generate a cartilaginous matrix prior to osteogenic commitment where they participate in bone repair through a process termed,endochondralossification(Jeffery et al.,2022).展开更多
基金the National Natural Science Foundation of China 82370914the International Science and Technology Cooperation Project of Hubei Province 2024EHA062(L.Zhu)R01-AR078783 from the the National Institutes of Health(S.Weiss)。
文摘The periosteum generally refers to the outer layer of bone,a specialized tissue primarily composed of fibroblasts and concentrically arranged typeⅠcollagen fibers that also serves as a reservoir for periosteal stem cells(Debnath et al.,2018).During physiological bone formation,periosteal stem cells contribute to osteogenesis via the intramembranous pathway,involving cell proliferation and osteogenic differentiation.Following bone damage,however,periosteal stem cells first differentiate into chondrocytes to generate a cartilaginous matrix prior to osteogenic commitment where they participate in bone repair through a process termed,endochondralossification(Jeffery et al.,2022).
