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Bioinspired Scalable Total Synthesis of Opioids
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作者 Xiaohan Zhou Wenfei Li +14 位作者 Ruijie Zhou Xiaoqing Wu Yuan Huang Wenlong Hou Chunxin Li Yifan Zhang Wei Nie Yu Wang Hao Song Xiao-Yu Liu Zhibing Zheng Fei Xie Song Li Wu Zhong Yong Qin 《CCS Chemistry》 CAS 2021年第9期1376-1383,共8页
As one of the largest and most representative families of natural medicines harvested from plants,the mass production of opioids legitimately occupies large,worldwide farmland cultivation of opium poppies,causing seve... As one of the largest and most representative families of natural medicines harvested from plants,the mass production of opioids legitimately occupies large,worldwide farmland cultivation of opium poppies,causing severe regulation limitations and supply uncertainty.Due to their complex structures,the chemical synthesis of opioids has been criticized as infeasible for large-scale production in view of lengthy synthetic steps and overall low efficiency. 展开更多
关键词 natural product total synthesis OPIOID MORPHINE OXYCODONE codeine dearo matization
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