OBJECTIVE: To evaluate the clinical efficacy and safety of Heyan Kuntai capsule(HYKT) in treating women with infertility caused by diminished ovarian reserve(DOR).METHODS: One hundred eight eligible patientsfrom three...OBJECTIVE: To evaluate the clinical efficacy and safety of Heyan Kuntai capsule(HYKT) in treating women with infertility caused by diminished ovarian reserve(DOR).METHODS: One hundred eight eligible patientsfrom three Chinese hospitals were randomly divided into an HYKT treatment group(n = 55) or a dehydroepiandrosterone(DHEA) treatment group(n =53). Patients in the HYKT group were treated orally with four 0.5 g HYKT three times a day; patients in the DHEA group were treated with one 25.0 mg DHEA capsule three times a day. All patients were treated for 3 months and followed up over a3-month period.RESULTS: Of 108 patients, 12 dropped out: six from the HYKT group, and six from the DHEA group. Eleven patients got pregnant during the treatment. Serum anti-Müllerian hormone levels and antral follicle counts increased significantly in both groups after treatment(P < 0.05) especially in the HYKT group(P < 0.05). Serum follicle stimulating hormone(FSH) levels and FSH/luteinizing hormone ratios decreased(P < 0.05) with no significant difference between the two groups. Estradiol levels in the HYKT group and DHEA-sulfate levels in the DHEA group both increased(P < 0.05). The spontaneous pregnancy rates were 12% and 11% in the HYKT and DHEA groups, respectively(not significant). During the follow-up period, 16 patients in the HYKT group underwent in vitro fertilization-embryo transfer(IVF-ET) and the number of retrieved oocytes was(5.1 ± 1.8). In DHEA group, 20 patients underwent IVF-ET and the number of retrieved oocyte was(4.2 ± 1.9)(not significant); clinical pregnancy rates were 38% in the HYKT group and 20%in DHEA group(not significant). No significant adverse reactions were observed.CONCLUSION: HYKT can improve the ovarian re-serve and hormone levels in patients with infertility caused by DOR. Pregnancy rates after HYKT treatment were similar to those of DHEA treatment.HYKT might be an alternative to the treatment of infertility caused by DOR.展开更多
OBJECTIVE: To evaluate the effectiveness of the Traditional Chinese Medicine tonifying-kidney and regulating-liver therapy on diminished ovarian reserve(DOR).METHODS: The literature was comprehensively searched up to ...OBJECTIVE: To evaluate the effectiveness of the Traditional Chinese Medicine tonifying-kidney and regulating-liver therapy on diminished ovarian reserve(DOR).METHODS: The literature was comprehensively searched up to August 2019 using four Chinese and three English electronic databases to extract randomized clinical trials(RCTs) comparing Traditional Chinese Medicine tonifying-kidney and regulating-liver prescriptions(combined with hormone therapy or not) with Western Medicine. Data quality evaluation was conducted using the Cochrane risk of bias tool. Meta-analysis was conducted using Revman 5.3 software with effect estimates presented as mean difference(MD), risk ratio(RR), and95% confidence interval(CI).RESULTS: A total of nine RCTs with 512 participants were extracted and eligible for Meta-analysis.There were no significant differences between Chinese medicine and Western Medicine on basal serum follicle-stimulating hormone(FSH) level(MD0.11, 95% CI-0.52 to 0.74, 392 participants, seven trials), anti-Müllerian hormone level(MD 0.48, 95%CI-0.62 to 1.58, 95 participants, two trials), and the FSH and luteinizing hormone ratio(MD 0.01,95% CI-0.95 to 0.96, 115 participants, two trials).Chinese medicine was more effective at improving Traditional Chinese Medicine symptom scores(TCMSS)(MD-2.39, 95% CI-3.83 to-0.94, 160 participants, three trials), effective rate of TCMSS(RR1.18, 95% CI 1.02 to 1.36, 160 participants, three trials), antral follicle count(AFC)(MD 0.55, 95% CI 0.05 to 1.04, 155 participants, three trials), and FSH levels at 3 months post-treatment(MD-4.77, 95% CI-6.09 to-3.45, 137 participants, two trials).CONCLUSION: Compared with Western Medicine,tonifying-kidney and regulating-liver therapy is more effective at relieving symptoms and improving AFC and FSH at 3 months post-treatment.展开更多
This paper discussed how to protect and control the quality of wild Chinese herbal medicine resources in nature reserves by taking Longyuwan National Forest Park within Funiu Mountain Nature Reserve as an example. Thr...This paper discussed how to protect and control the quality of wild Chinese herbal medicine resources in nature reserves by taking Longyuwan National Forest Park within Funiu Mountain Nature Reserve as an example. Through the combination of three methods including literature review, visiting and investigational studies, and field surveys, the data of investigation, collection and collation were analyzed. According to data of surveys, collection and collation, problems related to the protection of wild Chinese herbal medicine resources faced by Longyuwan Scenic Spot within Funiu Mountain Nature Reserve were also analyzed and protection strategies and quality control of wild Chinese herbal medicine resources in this nature reserve were discussed. It was expected that the results would provide important scientific references for the sustainable development, protection and quality control of wild Chinese herbal medicine resources within nature reserves.展开更多
Forest fire has received considerable attention in literature because it is considered one of the most common factors causing disturbances in ecosystems and at the same time considered vital in maintaining ecosystems....Forest fire has received considerable attention in literature because it is considered one of the most common factors causing disturbances in ecosystems and at the same time considered vital in maintaining ecosystems.Firewise Approach(FWA)has been proposed and used for controlling forest fire and achieving sustainable forest management.The approach requires involvement of communities in managing forest fire incidences in reserved forests.Despite considerable period since FWA has been practiced,there is insufficient scholarly knowledge on effectiveness of the approach in managing forest fire.This paper examines the effectiveness of FWA in managing forest fires in Uluguru Nature Forest Reserve(UNFR).The study employed cross-section research design that involved quantitative and qualitative data collection.The data were analysed using Statistical Package for Social Science(SPSS)software and content analysis.The study found alternating periods:the period of overall decrease of wildfire incidences within initial five years of practising the approach.The study concludes that the FWA is useful in reducing forest fire incidences during early period of practising the approach and another period of huge fire occurrence beyond five years.However,the FWA has challenges of sustaining successes in controlling forest fires including limited fire management training to common community.The study recommends sustaining communities’trainings on forest fire management.展开更多
To solve the problems facing the economic development of unconventional oil and gas, a new concept and corresponding technology system of reservoir stimulation based on "fracture-controlled reserves" are put...To solve the problems facing the economic development of unconventional oil and gas, a new concept and corresponding technology system of reservoir stimulation based on "fracture-controlled reserves" are put forward. The "fracture-controlled reserves" stimulation technology is to realize the three-dimensional producing and economic and efficient development of unconventional hydrocarbon resources by forming a fracture system that well matches "sweet spots" and "non-sweet spots". The technical route of the stimulation technology is "three optimizations and controls", that is, control the scope of sand body through optimizing well spacing, control the recoverable reserves through optimizing fracture system, and control the single well production reduction through optimizing energy complement method. The "fracture-controlled reserves" stimulation emphasizes the maximization of the initial stimulation coefficient, the integration of energy replenishment, stimulation and production, and prolonging the re-fracturing cycle or avoiding re-fracturing. It aims at realizing the three-dimensional full producing and efficient development of reservoir in vertical and horizontal directions and achieving the large-scale, sustainable and high profitable development of unconventional oil and gas resources. The stimulation technology was used to perform 20 pilot projects in five typical tight-oil, shale gas blocks in China. The fracturing and producing effects of tight oil improved and the commercial development for shale gas was realized.展开更多
Call admission control (CAC) and resource reservation (RR) for mobile communication are two important factors that guarantee system efficiency and quality of service (QoS) required for different services in a very sca...Call admission control (CAC) and resource reservation (RR) for mobile communication are two important factors that guarantee system efficiency and quality of service (QoS) required for different services in a very scarce resource as the radio spectrum. A new scheme was proposed which extends the concepts of resource sharing and reservations for wideband code division multiple access (WCDMA) systems with a unique feature of soft capacity. Voice and data traffic were considered. The traffic is further classified into handoff and new requests. The reservation thresholds were dynamically adjusted according to the traffic pattern and mobility prediction in order to achieve the maximum channel utilization, while guaranteeing different QoS constraints. The performance of proposed scheme was evaluated using Markov models. New call blocking probability, handoff call dropping probability, and channel utilization were used as benchmarks for the proposed scheme.展开更多
With the increase in the permeability of renewable energy and the frequency of extreme weather,the power system requires a large amount of flexible power regulation capacity.In order to realize the multi-day cooperati...With the increase in the permeability of renewable energy and the frequency of extreme weather,the power system requires a large amount of flexible power regulation capacity.In order to realize the multi-day cooperation of reserve resources,the stochastic optimization of medium-and short-term reserve arrangement considering the typhoon uncertainty is studied in this paper.Firstly,the extreme scenario generation and reduction method considering the typhoon path-intensity prediction uncertainty is constructed.Then,considering the combined cost of preventive and emergency control for adequacy in multiple scenarios,the reserve arrangement optimization model in extreme weather is built.In this model,the pre-dispatching strategies for multiple types of reserve resources are proposed to maintain the medium-and short-term coordination.Finally,case studies on a simplified 24-node power system of Zhejiang province,China are presented based on the data of the typhoon Fireworks in July 2021,and the result shows that the proposed reserve arrangement optimization model can reduce the total cost of power systems and the risk of operation under the typhoon disaster.展开更多
Myopia represents a critical public health challenge with far-reaching implications for future development,as global prevalence is projected to reach 49.8%by 2050(1–2).The Chinese government has implemented comprehen...Myopia represents a critical public health challenge with far-reaching implications for future development,as global prevalence is projected to reach 49.8%by 2050(1–2).The Chinese government has implemented comprehensive policies and proactive measures(3–6)to accelerate prevention efforts through systematic interventions.Traditional monitoring approaches have focused primarily on vision screening and diopter examination following myopia onset,thereby lacking early warning systems for tracking hyperopic reserve depletion.Commissioned by the National Disease Control and Prevention Bureau,our team has spearheaded a landmark large-scale monitoring project on hyperopic reserves among children and adolescents since 2020,encompassing ten provincial-level administrative divisions(PLADs;including Beijing,Liaoning,Zhejiang,Henan,Chongqing,Shaanxi,Guangdong,Shanxi,Hunan,and Shandong).展开更多
基金Supported by The Scientific research project of Administration of Traditional Chinese Medicine of Hebei Province:The Clinical Study of Kuntai Capsule in the Treatment of Infertility Women with Diminished Ovarian Reserve Diagnosed Liver-kidney Yin Deficiency and Heart-kidney Imbalance Syndrome(No.2016068)
文摘OBJECTIVE: To evaluate the clinical efficacy and safety of Heyan Kuntai capsule(HYKT) in treating women with infertility caused by diminished ovarian reserve(DOR).METHODS: One hundred eight eligible patientsfrom three Chinese hospitals were randomly divided into an HYKT treatment group(n = 55) or a dehydroepiandrosterone(DHEA) treatment group(n =53). Patients in the HYKT group were treated orally with four 0.5 g HYKT three times a day; patients in the DHEA group were treated with one 25.0 mg DHEA capsule three times a day. All patients were treated for 3 months and followed up over a3-month period.RESULTS: Of 108 patients, 12 dropped out: six from the HYKT group, and six from the DHEA group. Eleven patients got pregnant during the treatment. Serum anti-Müllerian hormone levels and antral follicle counts increased significantly in both groups after treatment(P < 0.05) especially in the HYKT group(P < 0.05). Serum follicle stimulating hormone(FSH) levels and FSH/luteinizing hormone ratios decreased(P < 0.05) with no significant difference between the two groups. Estradiol levels in the HYKT group and DHEA-sulfate levels in the DHEA group both increased(P < 0.05). The spontaneous pregnancy rates were 12% and 11% in the HYKT and DHEA groups, respectively(not significant). During the follow-up period, 16 patients in the HYKT group underwent in vitro fertilization-embryo transfer(IVF-ET) and the number of retrieved oocytes was(5.1 ± 1.8). In DHEA group, 20 patients underwent IVF-ET and the number of retrieved oocyte was(4.2 ± 1.9)(not significant); clinical pregnancy rates were 38% in the HYKT group and 20%in DHEA group(not significant). No significant adverse reactions were observed.CONCLUSION: HYKT can improve the ovarian re-serve and hormone levels in patients with infertility caused by DOR. Pregnancy rates after HYKT treatment were similar to those of DHEA treatment.HYKT might be an alternative to the treatment of infertility caused by DOR.
基金Supported by the Fundamental Research Funds for the Central Universities Study on the Mechanism of Tonifying-Kidney and Smoothing-Liver on Rats With Diminished Ovarian Reserve Based on PI3K-AKT-mTOR Signaling Pathway(No.2019-JYB-XS-148)National Natural Science Foundation of China Study on the Mechanism of Regulating Endometrial Receptivity by Erbu Zhuyu Decoction Based on NK/M-CSF/NO Signaling Pathway(No.81473721)。
文摘OBJECTIVE: To evaluate the effectiveness of the Traditional Chinese Medicine tonifying-kidney and regulating-liver therapy on diminished ovarian reserve(DOR).METHODS: The literature was comprehensively searched up to August 2019 using four Chinese and three English electronic databases to extract randomized clinical trials(RCTs) comparing Traditional Chinese Medicine tonifying-kidney and regulating-liver prescriptions(combined with hormone therapy or not) with Western Medicine. Data quality evaluation was conducted using the Cochrane risk of bias tool. Meta-analysis was conducted using Revman 5.3 software with effect estimates presented as mean difference(MD), risk ratio(RR), and95% confidence interval(CI).RESULTS: A total of nine RCTs with 512 participants were extracted and eligible for Meta-analysis.There were no significant differences between Chinese medicine and Western Medicine on basal serum follicle-stimulating hormone(FSH) level(MD0.11, 95% CI-0.52 to 0.74, 392 participants, seven trials), anti-Müllerian hormone level(MD 0.48, 95%CI-0.62 to 1.58, 95 participants, two trials), and the FSH and luteinizing hormone ratio(MD 0.01,95% CI-0.95 to 0.96, 115 participants, two trials).Chinese medicine was more effective at improving Traditional Chinese Medicine symptom scores(TCMSS)(MD-2.39, 95% CI-3.83 to-0.94, 160 participants, three trials), effective rate of TCMSS(RR1.18, 95% CI 1.02 to 1.36, 160 participants, three trials), antral follicle count(AFC)(MD 0.55, 95% CI 0.05 to 1.04, 155 participants, three trials), and FSH levels at 3 months post-treatment(MD-4.77, 95% CI-6.09 to-3.45, 137 participants, two trials).CONCLUSION: Compared with Western Medicine,tonifying-kidney and regulating-liver therapy is more effective at relieving symptoms and improving AFC and FSH at 3 months post-treatment.
基金Supported by Funding from the State Nationalities Affairs Commission(2015-GM-178)National Training Programs of Innovation and Entrepreneurship for Undergraduates(GCYS2016110001)
文摘This paper discussed how to protect and control the quality of wild Chinese herbal medicine resources in nature reserves by taking Longyuwan National Forest Park within Funiu Mountain Nature Reserve as an example. Through the combination of three methods including literature review, visiting and investigational studies, and field surveys, the data of investigation, collection and collation were analyzed. According to data of surveys, collection and collation, problems related to the protection of wild Chinese herbal medicine resources faced by Longyuwan Scenic Spot within Funiu Mountain Nature Reserve were also analyzed and protection strategies and quality control of wild Chinese herbal medicine resources in this nature reserve were discussed. It was expected that the results would provide important scientific references for the sustainable development, protection and quality control of wild Chinese herbal medicine resources within nature reserves.
文摘Forest fire has received considerable attention in literature because it is considered one of the most common factors causing disturbances in ecosystems and at the same time considered vital in maintaining ecosystems.Firewise Approach(FWA)has been proposed and used for controlling forest fire and achieving sustainable forest management.The approach requires involvement of communities in managing forest fire incidences in reserved forests.Despite considerable period since FWA has been practiced,there is insufficient scholarly knowledge on effectiveness of the approach in managing forest fire.This paper examines the effectiveness of FWA in managing forest fires in Uluguru Nature Forest Reserve(UNFR).The study employed cross-section research design that involved quantitative and qualitative data collection.The data were analysed using Statistical Package for Social Science(SPSS)software and content analysis.The study found alternating periods:the period of overall decrease of wildfire incidences within initial five years of practising the approach.The study concludes that the FWA is useful in reducing forest fire incidences during early period of practising the approach and another period of huge fire occurrence beyond five years.However,the FWA has challenges of sustaining successes in controlling forest fires including limited fire management training to common community.The study recommends sustaining communities’trainings on forest fire management.
基金Supported by the National Science and Technology Major Project(2016ZX05046-004,2016ZX05023-005)
文摘To solve the problems facing the economic development of unconventional oil and gas, a new concept and corresponding technology system of reservoir stimulation based on "fracture-controlled reserves" are put forward. The "fracture-controlled reserves" stimulation technology is to realize the three-dimensional producing and economic and efficient development of unconventional hydrocarbon resources by forming a fracture system that well matches "sweet spots" and "non-sweet spots". The technical route of the stimulation technology is "three optimizations and controls", that is, control the scope of sand body through optimizing well spacing, control the recoverable reserves through optimizing fracture system, and control the single well production reduction through optimizing energy complement method. The "fracture-controlled reserves" stimulation emphasizes the maximization of the initial stimulation coefficient, the integration of energy replenishment, stimulation and production, and prolonging the re-fracturing cycle or avoiding re-fracturing. It aims at realizing the three-dimensional full producing and efficient development of reservoir in vertical and horizontal directions and achieving the large-scale, sustainable and high profitable development of unconventional oil and gas resources. The stimulation technology was used to perform 20 pilot projects in five typical tight-oil, shale gas blocks in China. The fracturing and producing effects of tight oil improved and the commercial development for shale gas was realized.
文摘Call admission control (CAC) and resource reservation (RR) for mobile communication are two important factors that guarantee system efficiency and quality of service (QoS) required for different services in a very scarce resource as the radio spectrum. A new scheme was proposed which extends the concepts of resource sharing and reservations for wideband code division multiple access (WCDMA) systems with a unique feature of soft capacity. Voice and data traffic were considered. The traffic is further classified into handoff and new requests. The reservation thresholds were dynamically adjusted according to the traffic pattern and mobility prediction in order to achieve the maximum channel utilization, while guaranteeing different QoS constraints. The performance of proposed scheme was evaluated using Markov models. New call blocking probability, handoff call dropping probability, and channel utilization were used as benchmarks for the proposed scheme.
基金supported by the Science and Technology Project of NARI Technology Co.,Ltd.“Interaction and Coordination Technology of Information-Physical-Social Elements”(No.GF-GFWD-210338)。
文摘With the increase in the permeability of renewable energy and the frequency of extreme weather,the power system requires a large amount of flexible power regulation capacity.In order to realize the multi-day cooperation of reserve resources,the stochastic optimization of medium-and short-term reserve arrangement considering the typhoon uncertainty is studied in this paper.Firstly,the extreme scenario generation and reduction method considering the typhoon path-intensity prediction uncertainty is constructed.Then,considering the combined cost of preventive and emergency control for adequacy in multiple scenarios,the reserve arrangement optimization model in extreme weather is built.In this model,the pre-dispatching strategies for multiple types of reserve resources are proposed to maintain the medium-and short-term coordination.Finally,case studies on a simplified 24-node power system of Zhejiang province,China are presented based on the data of the typhoon Fireworks in July 2021,and the result shows that the proposed reserve arrangement optimization model can reduce the total cost of power systems and the risk of operation under the typhoon disaster.
文摘Myopia represents a critical public health challenge with far-reaching implications for future development,as global prevalence is projected to reach 49.8%by 2050(1–2).The Chinese government has implemented comprehensive policies and proactive measures(3–6)to accelerate prevention efforts through systematic interventions.Traditional monitoring approaches have focused primarily on vision screening and diopter examination following myopia onset,thereby lacking early warning systems for tracking hyperopic reserve depletion.Commissioned by the National Disease Control and Prevention Bureau,our team has spearheaded a landmark large-scale monitoring project on hyperopic reserves among children and adolescents since 2020,encompassing ten provincial-level administrative divisions(PLADs;including Beijing,Liaoning,Zhejiang,Henan,Chongqing,Shaanxi,Guangdong,Shanxi,Hunan,and Shandong).
