Exercise is recommended for the treatment of type 2 diabetes because of its benefits on body weight and glycemic control. Our recent work using the db/db mouse, a model that mimics the phenotype of type 2 diabetes, de...Exercise is recommended for the treatment of type 2 diabetes because of its benefits on body weight and glycemic control. Our recent work using the db/db mouse, a model that mimics the phenotype of type 2 diabetes, demonstrated that forced treadmill training exerted detrimental effects on obesity, hyperglycemia and insulin resistance. We investigated whether this response is explained by increased corticosterone and norepinephrine secretion, measured as urinary byproducts, since these hormones are known to alter glucose homeostasis. Male db/db mice and lean littermates serving as controls, were assigned to sedentary, voluntary wheel, and forced treadmill training groups for a period of 5 weeks. After 5 weeks of treadmill running, db/db mice remained hyperglycemic compared to sedentary db/db mice and were hyperinsulinemic compared to db/db voluntary runners. Urine glucose and corticosterone levels were also highest in db/db treadmill runners compared to all groups. Urine normetanephrine levels, although lower in db/db mice compared to control mice, were increased after treadmill running. Our results indicate that treadmill running leads to perturbations in plasma levels of hormones associated with glucose homeostasis. A greater stress response may be invoked by treadmill training, worsening glycemic control in this model of type 2 diabetes.展开更多
向量数据库是一种专门用于管理高维数据的数据库系统.与传统数据库系统主要处理结构化数据不同,向量数据库专注于存储和检索以向量形式表示的数据,这些数据可以是文本、图像、音频等复杂数据类型.在大数据和人工智能技术的驱动下,向量...向量数据库是一种专门用于管理高维数据的数据库系统.与传统数据库系统主要处理结构化数据不同,向量数据库专注于存储和检索以向量形式表示的数据,这些数据可以是文本、图像、音频等复杂数据类型.在大数据和人工智能技术的驱动下,向量数据库已经广泛应用于信息检索、推荐系统、语音识别、图像分析等领域,成为数字化转型和智能化发展的重要推动力.然而,面对海量高维向量数据的实时更新、存储、检索与分析需求,特别是来自大语言模型(large language model,LLM)等人工智能技术的应用需求,传统数据库技术还面临着许多挑战,亟须发展新的数据库理论、方法与技术,提高向量数据库对实际应用场景的支持能力.展开更多
文摘Exercise is recommended for the treatment of type 2 diabetes because of its benefits on body weight and glycemic control. Our recent work using the db/db mouse, a model that mimics the phenotype of type 2 diabetes, demonstrated that forced treadmill training exerted detrimental effects on obesity, hyperglycemia and insulin resistance. We investigated whether this response is explained by increased corticosterone and norepinephrine secretion, measured as urinary byproducts, since these hormones are known to alter glucose homeostasis. Male db/db mice and lean littermates serving as controls, were assigned to sedentary, voluntary wheel, and forced treadmill training groups for a period of 5 weeks. After 5 weeks of treadmill running, db/db mice remained hyperglycemic compared to sedentary db/db mice and were hyperinsulinemic compared to db/db voluntary runners. Urine glucose and corticosterone levels were also highest in db/db treadmill runners compared to all groups. Urine normetanephrine levels, although lower in db/db mice compared to control mice, were increased after treadmill running. Our results indicate that treadmill running leads to perturbations in plasma levels of hormones associated with glucose homeostasis. A greater stress response may be invoked by treadmill training, worsening glycemic control in this model of type 2 diabetes.
文摘向量数据库是一种专门用于管理高维数据的数据库系统.与传统数据库系统主要处理结构化数据不同,向量数据库专注于存储和检索以向量形式表示的数据,这些数据可以是文本、图像、音频等复杂数据类型.在大数据和人工智能技术的驱动下,向量数据库已经广泛应用于信息检索、推荐系统、语音识别、图像分析等领域,成为数字化转型和智能化发展的重要推动力.然而,面对海量高维向量数据的实时更新、存储、检索与分析需求,特别是来自大语言模型(large language model,LLM)等人工智能技术的应用需求,传统数据库技术还面临着许多挑战,亟须发展新的数据库理论、方法与技术,提高向量数据库对实际应用场景的支持能力.
