Objective To investigate the level of urinary serine protease(Corin)in early diabetic kidney disease(DKD)and its correlation with clinical stage.Methods One hundred and seventy-three patients with type 2 diabetes mell...Objective To investigate the level of urinary serine protease(Corin)in early diabetic kidney disease(DKD)and its correlation with clinical stage.Methods One hundred and seventy-three patients with type 2 diabetes mellitus(DM)from two tertiary A hospitals in Henan,diagnosed between April 2023 and December 2023 were selected as the research group,and 120 healthy subjects were selected as the contro1lgroup.Basicclinical information and laboratory datawere collected,and urinary Corin level was detected.DM patients were classified into G1-G5 stages based on estimated glomerular filtration rate(eGFR),and those in the early DKD stages(G1-G3)were further divided into A1-A3 subgroups based on urinary albumin/creatinine ratio(ACR).Spearman correlation analysis was performed to assess relationships between urinary Corin and other indicators,linear regression analysis identified factors influencing urinary Corin in early DKD patients,logistic regression analysis evaluated the risk factors for early DKD,and receiver operating characteristic(ROC)curve analysis determined the diagnostic value of urinary Corin in early DKD.Results Urinary Corin levels were significantly higher in early DKD patients compared to healthy controls,with levels increasing as ACR rose(P<0.05).Urinary Corin was positively associated with serum creatinine(r=0.570),urea(r=0.458),cystatin C(r=0.693),ACR(r=0.616),urinary transferrin(r=0.448),urinaryαl microglobulin(r=0.507),urinary n-acetyl-β-D-glucosaminase(r=0.388)and A subgroup(r=0.692)while was negatively correlated with eGFR(r=-0.647),albumin(r=-0.312)(all P<0.05).eGFR was the only independent factor affecting urinary Corin.After adjusting for confounding factors in logistic regression analysis,urinary Corin was still an independent influencing factor for early DKD.ROC curve analysis indicated that urinary Corin had a diagnostic AUC of 0.842(95%CI 0.791-0.892,P<0.001),with a cut-off value of 2226.04 pg/mL,sensitivity of 0.712,and specificity of 0.858 for early DKD diagnosis.Conclusion Urinary Corin is elevated in early DKD patients and correlated with clinical stage.Urinary Corin is an independent factor of early DKD and a reliable predictor of early DKD diagnosis.展开更多
文摘Objective To investigate the level of urinary serine protease(Corin)in early diabetic kidney disease(DKD)and its correlation with clinical stage.Methods One hundred and seventy-three patients with type 2 diabetes mellitus(DM)from two tertiary A hospitals in Henan,diagnosed between April 2023 and December 2023 were selected as the research group,and 120 healthy subjects were selected as the contro1lgroup.Basicclinical information and laboratory datawere collected,and urinary Corin level was detected.DM patients were classified into G1-G5 stages based on estimated glomerular filtration rate(eGFR),and those in the early DKD stages(G1-G3)were further divided into A1-A3 subgroups based on urinary albumin/creatinine ratio(ACR).Spearman correlation analysis was performed to assess relationships between urinary Corin and other indicators,linear regression analysis identified factors influencing urinary Corin in early DKD patients,logistic regression analysis evaluated the risk factors for early DKD,and receiver operating characteristic(ROC)curve analysis determined the diagnostic value of urinary Corin in early DKD.Results Urinary Corin levels were significantly higher in early DKD patients compared to healthy controls,with levels increasing as ACR rose(P<0.05).Urinary Corin was positively associated with serum creatinine(r=0.570),urea(r=0.458),cystatin C(r=0.693),ACR(r=0.616),urinary transferrin(r=0.448),urinaryαl microglobulin(r=0.507),urinary n-acetyl-β-D-glucosaminase(r=0.388)and A subgroup(r=0.692)while was negatively correlated with eGFR(r=-0.647),albumin(r=-0.312)(all P<0.05).eGFR was the only independent factor affecting urinary Corin.After adjusting for confounding factors in logistic regression analysis,urinary Corin was still an independent influencing factor for early DKD.ROC curve analysis indicated that urinary Corin had a diagnostic AUC of 0.842(95%CI 0.791-0.892,P<0.001),with a cut-off value of 2226.04 pg/mL,sensitivity of 0.712,and specificity of 0.858 for early DKD diagnosis.Conclusion Urinary Corin is elevated in early DKD patients and correlated with clinical stage.Urinary Corin is an independent factor of early DKD and a reliable predictor of early DKD diagnosis.
