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A Convolutional Neural Network-Based Deep Support Vector Machine for Parkinson’s Disease Detection with Small-Scale and Imbalanced Datasets
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作者 Kwok Tai Chui Varsha Arya +2 位作者 Brij B.Gupta Miguel Torres-Ruiz Razaz Waheeb Attar 《Computers, Materials & Continua》 2026年第1期1410-1432,共23页
Parkinson’s disease(PD)is a debilitating neurological disorder affecting over 10 million people worldwide.PD classification models using voice signals as input are common in the literature.It is believed that using d... Parkinson’s disease(PD)is a debilitating neurological disorder affecting over 10 million people worldwide.PD classification models using voice signals as input are common in the literature.It is believed that using deep learning algorithms further enhances performance;nevertheless,it is challenging due to the nature of small-scale and imbalanced PD datasets.This paper proposed a convolutional neural network-based deep support vector machine(CNN-DSVM)to automate the feature extraction process using CNN and extend the conventional SVM to a DSVM for better classification performance in small-scale PD datasets.A customized kernel function reduces the impact of biased classification towards the majority class(healthy candidates in our consideration).An improved generative adversarial network(IGAN)was designed to generate additional training data to enhance the model’s performance.For performance evaluation,the proposed algorithm achieves a sensitivity of 97.6%and a specificity of 97.3%.The performance comparison is evaluated from five perspectives,including comparisons with different data generation algorithms,feature extraction techniques,kernel functions,and existing works.Results reveal the effectiveness of the IGAN algorithm,which improves the sensitivity and specificity by 4.05%–4.72%and 4.96%–5.86%,respectively;and the effectiveness of the CNN-DSVM algorithm,which improves the sensitivity by 1.24%–57.4%and specificity by 1.04%–163%and reduces biased detection towards the majority class.The ablation experiments confirm the effectiveness of individual components.Two future research directions have also been suggested. 展开更多
关键词 Convolutional neural network data generation deep support vector machine feature extraction generative artificial intelligence imbalanced dataset medical diagnosis Parkinson’s disease small-scale dataset
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基于TDIM的高精度功率SMD结壳热阻测量技术
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作者 吴玉强 郑花 +3 位作者 马凤丽 侯杰 许为新 郭美洋 《半导体技术》 北大核心 2025年第12期1237-1243,共7页
为解决传统热阻测量中功率表面贴装器件(SMD)散热基板与电学引出端共面导致短路及热电偶法测量误差问题,提出一种基于瞬态双界面法(TDIM)的高精度结壳热阻(R_(θJC))测量技术。通过设计含铜板凸台结构与绝缘定位板的专用夹具,有效避免... 为解决传统热阻测量中功率表面贴装器件(SMD)散热基板与电学引出端共面导致短路及热电偶法测量误差问题,提出一种基于瞬态双界面法(TDIM)的高精度结壳热阻(R_(θJC))测量技术。通过设计含铜板凸台结构与绝缘定位板的专用夹具,有效避免了电气短路;结合TDIM替代热电偶法,消除了热量“芯吸”效应与测温位置误差。以TO-277封装肖特基二极管为实验对象,测得其R_(θJC)为0.302 K/W,与器件手册典型值(0.30 K/W)误差仅0.67%。通过在相同结温(423.15 K)下实施两次热表征,显著抑制了温度依赖性误差。本技术为功率SMD的热管理设计提供了可靠的测量方案,具备工程推广价值。 展开更多
关键词 瞬态双界面法(TDIM) 表面贴装器件(smd) 结壳热阻 专用夹具 热表征 热管理 一维热流路径
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Standardizing Healthcare Datasets in China:Challenges and Strategies
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作者 Zheng-Yong Hu Xiao-Lei Xiu +2 位作者 Jing-Yu Zhang Wan-Fei Hu Si-Zhu Wu 《Chinese Medical Sciences Journal》 2025年第4期253-267,I0001,共16页
Standardized datasets are foundational to healthcare informatization by enhancing data quality and unleashing the value of data elements.Using bibliometrics and content analysis,this study examines China's healthc... Standardized datasets are foundational to healthcare informatization by enhancing data quality and unleashing the value of data elements.Using bibliometrics and content analysis,this study examines China's healthcare dataset standards from 2011 to 2025.It analyzes their evolution across types,applications,institutions,and themes,highlighting key achievements including substantial growth in quantity,optimized typology,expansion into innovative application scenarios such as health decision support,and broadened institutional involvement.The study also identifies critical challenges,including imbalanced development,insufficient quality control,and a lack of essential metadata—such as authoritative data element mappings and privacy annotations—which hampers the delivery of intelligent services.To address these challenges,the study proposes a multi-faceted strategy focused on optimizing the standard system's architecture,enhancing quality and implementation,and advancing both data governance—through authoritative tracing and privacy protection—and intelligent service provision.These strategies aim to promote the application of dataset standards,thereby fostering and securing the development of new productive forces in healthcare. 展开更多
关键词 healthcare dataset standards data standardization data management
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DCS-SOCP-SVM:A Novel Integrated Sampling and Classification Algorithm for Imbalanced Datasets
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作者 Xuewen Mu Bingcong Zhao 《Computers, Materials & Continua》 2025年第5期2143-2159,共17页
When dealing with imbalanced datasets,the traditional support vectormachine(SVM)tends to produce a classification hyperplane that is biased towards the majority class,which exhibits poor robustness.This paper proposes... When dealing with imbalanced datasets,the traditional support vectormachine(SVM)tends to produce a classification hyperplane that is biased towards the majority class,which exhibits poor robustness.This paper proposes a high-performance classification algorithm specifically designed for imbalanced datasets.The proposed method first uses a biased second-order cone programming support vectormachine(B-SOCP-SVM)to identify the support vectors(SVs)and non-support vectors(NSVs)in the imbalanced data.Then,it applies the synthetic minority over-sampling technique(SV-SMOTE)to oversample the support vectors of the minority class and uses the random under-sampling technique(NSV-RUS)multiple times to undersample the non-support vectors of the majority class.Combining the above-obtained minority class data set withmultiple majority class datasets can obtainmultiple new balanced data sets.Finally,SOCP-SVM is used to classify each data set,and the final result is obtained through the integrated algorithm.Experimental results demonstrate that the proposed method performs excellently on imbalanced datasets. 展开更多
关键词 DCS-SOCP-SVM imbalanced datasets sampling method ensemble method integrated algorithm
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A Comprehensive Review of Face Detection Techniques for Occluded Faces:Methods,Datasets,and Open Challenges
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作者 Thaer Thaher Majdi Mafarja +2 位作者 Muhammed Saffarini Abdul Hakim H.M.Mohamed Ayman A.El-Saleh 《Computer Modeling in Engineering & Sciences》 2025年第6期2615-2673,共59页
Detecting faces under occlusion remains a significant challenge in computer vision due to variations caused by masks,sunglasses,and other obstructions.Addressing this issue is crucial for applications such as surveill... Detecting faces under occlusion remains a significant challenge in computer vision due to variations caused by masks,sunglasses,and other obstructions.Addressing this issue is crucial for applications such as surveillance,biometric authentication,and human-computer interaction.This paper provides a comprehensive review of face detection techniques developed to handle occluded faces.Studies are categorized into four main approaches:feature-based,machine learning-based,deep learning-based,and hybrid methods.We analyzed state-of-the-art studies within each category,examining their methodologies,strengths,and limitations based on widely used benchmark datasets,highlighting their adaptability to partial and severe occlusions.The review also identifies key challenges,including dataset diversity,model generalization,and computational efficiency.Our findings reveal that deep learning methods dominate recent studies,benefiting from their ability to extract hierarchical features and handle complex occlusion patterns.More recently,researchers have increasingly explored Transformer-based architectures,such as Vision Transformer(ViT)and Swin Transformer,to further improve detection robustness under challenging occlusion scenarios.In addition,hybrid approaches,which aim to combine traditional andmodern techniques,are emerging as a promising direction for improving robustness.This review provides valuable insights for researchers aiming to develop more robust face detection systems and for practitioners seeking to deploy reliable solutions in real-world,occlusionprone environments.Further improvements and the proposal of broader datasets are required to developmore scalable,robust,and efficient models that can handle complex occlusions in real-world scenarios. 展开更多
关键词 Occluded face detection feature-based deep learning machine learning hybrid approaches datasets
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Impact of climate changes on Arizona State precipitation patterns using high-resolution climatic gridded datasets
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作者 Hayder H.Kareem Shahla Abdulqader Nassrullah 《Journal of Groundwater Science and Engineering》 2025年第1期34-46,共13页
Climate change significantly affects environment,ecosystems,communities,and economies.These impacts often result in quick and gradual changes in water resources,environmental conditions,and weather patterns.A geograph... Climate change significantly affects environment,ecosystems,communities,and economies.These impacts often result in quick and gradual changes in water resources,environmental conditions,and weather patterns.A geographical study was conducted in Arizona State,USA,to examine monthly precipi-tation concentration rates over time.This analysis used a high-resolution 0.50×0.50 grid for monthly precip-itation data from 1961 to 2022,Provided by the Climatic Research Unit.The study aimed to analyze climatic changes affected the first and last five years of each decade,as well as the entire decade,during the specified period.GIS was used to meet the objectives of this study.Arizona experienced 51–568 mm,67–560 mm,63–622 mm,and 52–590 mm of rainfall in the sixth,seventh,eighth,and ninth decades of the second millennium,respectively.Both the first and second five year periods of each decade showed accept-able rainfall amounts despite fluctuations.However,rainfall decreased in the first and second decades of the third millennium.and in the first two years of the third decade.Rainfall amounts dropped to 42–472 mm,55–469 mm,and 74–498 mm,respectively,indicating a downward trend in precipitation.The central part of the state received the highest rainfall,while the eastern and western regions(spanning north to south)had significantly less.Over the decades of the third millennium,the average annual rainfall every five years was relatively low,showing a declining trend due to severe climate changes,generally ranging between 35 mm and 498 mm.The central regions consistently received more rainfall than the eastern and western outskirts.Arizona is currently experiencing a decrease in rainfall due to climate change,a situation that could deterio-rate further.This highlights the need to optimize the use of existing rainfall and explore alternative water sources. 展开更多
关键词 Spatial Analysis Climate Impact Precipitation Rates CRU Dataset GIS Arizona State USA
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A Comprehensive Review of Face Detection/Recognition Algorithms and Competitive Datasets to Optimize Machine Vision
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作者 Mahmood Ul Haq Muhammad Athar Javed Sethi +3 位作者 Sadique Ahmad Naveed Ahmad Muhammad Shahid Anwar Alpamis Kutlimuratov 《Computers, Materials & Continua》 2025年第7期1-24,共24页
Face recognition has emerged as one of the most prominent applications of image analysis and under-standing,gaining considerable attention in recent years.This growing interest is driven by two key factors:its extensi... Face recognition has emerged as one of the most prominent applications of image analysis and under-standing,gaining considerable attention in recent years.This growing interest is driven by two key factors:its extensive applications in law enforcement and the commercial domain,and the rapid advancement of practical technologies.Despite the significant advancements,modern recognition algorithms still struggle in real-world conditions such as varying lighting conditions,occlusion,and diverse facial postures.In such scenarios,human perception is still well above the capabilities of present technology.Using the systematic mapping study,this paper presents an in-depth review of face detection algorithms and face recognition algorithms,presenting a detailed survey of advancements made between 2015 and 2024.We analyze key methodologies,highlighting their strengths and restrictions in the application context.Additionally,we examine various datasets used for face detection/recognition datasets focusing on the task-specific applications,size,diversity,and complexity.By analyzing these algorithms and datasets,this survey works as a valuable resource for researchers,identifying the research gap in the field of face detection and recognition and outlining potential directions for future research. 展开更多
关键词 Face recognition algorithms face detection techniques face recognition/detection datasets
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The Development of Artificial Intelligence:Toward Consistency in the Logical Structures of Datasets,AI Models,Model Building,and Hardware?
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作者 Li Guo Jinghai Li 《Engineering》 2025年第7期13-17,共5页
The aim of this article is to explore potential directions for the development of artificial intelligence(AI).It points out that,while current AI can handle the statistical properties of complex systems,it has difficu... The aim of this article is to explore potential directions for the development of artificial intelligence(AI).It points out that,while current AI can handle the statistical properties of complex systems,it has difficulty effectively processing and fully representing their spatiotemporal complexity patterns.The article also discusses a potential path of AI development in the engineering domain.Based on the existing understanding of the principles of multilevel com-plexity,this article suggests that consistency among the logical structures of datasets,AI models,model-building software,and hardware will be an important AI development direction and is worthy of careful consideration. 展开更多
关键词 CONSISTENCY datasets model building ai models artificial intelligence ai explore potential directions HARDWARE artificial intelligence
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A critical evaluation of deep-learning based phylogenetic inference programs using simulated datasets
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作者 Yixiao Zhu Yonglin Li +2 位作者 Chuhao Li Xing-Xing Shen Xiaofan Zhou 《Journal of Genetics and Genomics》 2025年第5期714-717,共4页
Inferring phylogenetic trees from molecular sequences is a cornerstone of evolutionary biology.Many standard phylogenetic methods(such as maximum-likelihood[ML])rely on explicit models of sequence evolution and thus o... Inferring phylogenetic trees from molecular sequences is a cornerstone of evolutionary biology.Many standard phylogenetic methods(such as maximum-likelihood[ML])rely on explicit models of sequence evolution and thus often suffer from model misspecification or inadequacy.The on-rising deep learning(DL)techniques offer a powerful alternative.Deep learning employs multi-layered artificial neural networks to progressively transform input data into more abstract and complex representations.DL methods can autonomously uncover meaningful patterns from data,thereby bypassing potential biases introduced by predefined features(Franklin,2005;Murphy,2012).Recent efforts have aimed to apply deep neural networks(DNNs)to phylogenetics,with a growing number of applications in tree reconstruction(Suvorov et al.,2020;Zou et al.,2020;Nesterenko et al.,2022;Smith and Hahn,2023;Wang et al.,2023),substitution model selection(Abadi et al.,2020;Burgstaller-Muehlbacher et al.,2023),and diversification rate inference(Voznica et al.,2022;Lajaaiti et al.,2023;Lambert et al.,2023).In phylogenetic tree reconstruction,PhyDL(Zou et al.,2020)and Tree_learning(Suvorov et al.,2020)are two notable DNN-based programs designed to infer unrooted quartet trees directly from alignments of four amino acid(AA)and DNA sequences,respectively. 展开更多
关键词 phylogenetic inference explicit models sequence evolution deep learning deep learning dl techniques molecular sequences simulated datasets phylogenetic methods such evolutionary biologymany
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Impacts of random negative training datasets on machine learning-based geologic hazard susceptibility assessment
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作者 Hao Cheng Wei Hong +3 位作者 Zhen-kai Zhang Zeng-lin Hong Zi-yao Wang Yu-xuan Dong 《China Geology》 2025年第4期676-690,共15页
This study investigated the impacts of random negative training datasets(NTDs)on the uncertainty of machine learning models for geologic hazard susceptibility assessment of the Loess Plateau,northern Shaanxi Province,... This study investigated the impacts of random negative training datasets(NTDs)on the uncertainty of machine learning models for geologic hazard susceptibility assessment of the Loess Plateau,northern Shaanxi Province,China.Based on randomly generated 40 NTDs,the study developed models for the geologic hazard susceptibility assessment using the random forest algorithm and evaluated their performances using the area under the receiver operating characteristic curve(AUC).Specifically,the means and standard deviations of the AUC values from all models were then utilized to assess the overall spatial correlation between the conditioning factors and the susceptibility assessment,as well as the uncertainty introduced by the NTDs.A risk and return methodology was thus employed to quantify and mitigate the uncertainty,with log odds ratios used to characterize the susceptibility assessment levels.The risk and return values were calculated based on the standard deviations and means of the log odds ratios of various locations.After the mean log odds ratios were converted into probability values,the final susceptibility map was plotted,which accounts for the uncertainty induced by random NTDs.The results indicate that the AUC values of the models ranged from 0.810 to 0.963,with an average of 0.852 and a standard deviation of 0.035,indicating encouraging prediction effects and certain uncertainty.The risk and return analysis reveals that low-risk and high-return areas suggest lower standard deviations and higher means across multiple model-derived assessments.Overall,this study introduces a new framework for quantifying the uncertainty of multiple training and evaluation models,aimed at improving their robustness and reliability.Additionally,by identifying low-risk and high-return areas,resource allocation for geologic hazard prevention and control can be optimized,thus ensuring that limited resources are directed toward the most effective prevention and control measures. 展开更多
关键词 LANDSLIDES Debris flows Collapses Ground fissures Geologic hazard prevention and control ENGINEERING Geologic hazard susceptibility assessment Negative training dataset Average spatial correlation Random forest algorithm Risk and return analysis Geological survey engineering Loess Plateau area
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基于改进RT-DETR的有遮挡交通标志检测算法
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作者 于天河 杨壮壮 +2 位作者 胡金帅 常梦瑶 王文龙 《工程科学学报》 北大核心 2026年第2期393-408,共16页
针对交通标志检测中目标尺寸小、检测精度低等问题,尤其是在远距离拍摄、遮挡严重的情况下,传统检测算法往往难以准确识别交通标志.本文提出了一种基于改进RT-DETR的交通标志检测算法.首先,考虑到当前交通标志被遮挡情况下数据集的匮乏... 针对交通标志检测中目标尺寸小、检测精度低等问题,尤其是在远距离拍摄、遮挡严重的情况下,传统检测算法往往难以准确识别交通标志.本文提出了一种基于改进RT-DETR的交通标志检测算法.首先,考虑到当前交通标志被遮挡情况下数据集的匮乏,自建一个遮挡条件下的交通标志数据集.然后,在反向残差移动块中引入膨胀重参数块,构建了一个轻量级的复合膨胀残差块来替换原始主干提取网络中的BasicBlock,增强了模型的特征提取能力.最后,对RT-DETR模型的损失函数进行了优化,提出了DS-IoU联合损失函数加快收模型敛速度.实验结果表明,改进后的算法在自制数据集上的m AP为94.2%,相比于原始算法增加量为4.7%,在公开数据集TT100K和CCTSDB2021的m AP分别为92.8%和91.7%,相比于原始算法增加量分别为3.1%和2.4%,Params和GFLOPs相比于原始的算法分别降低了26.0%和12.5%.本文提出的改进方法极大地减少了计算量和参数数量,有效提升了遮挡情况下的交通标志的检测精度. 展开更多
关键词 交通标志检测 RT-DETR 遮挡数据集 轻量化 联合损失函数
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凝聚青年力量 共话信息未来——记江苏省研究生第一届信息资源管理学术创新论坛
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作者 刘琼 刘桂锋 《图书情报研究》 2026年第1期90-96,共7页
2025年11月7日至9日,“江苏省研究生第一届信息资源管理学术创新论坛”在江苏大学成功召开。论坛聚焦信息资源管理学科的前沿发展,旨在推动学科交叉融合与学术创新。会议共设置五场主旨报告,内容涵盖信息资源管理的学科属性与范式演进... 2025年11月7日至9日,“江苏省研究生第一届信息资源管理学术创新论坛”在江苏大学成功召开。论坛聚焦信息资源管理学科的前沿发展,旨在推动学科交叉融合与学术创新。会议共设置五场主旨报告,内容涵盖信息资源管理的学科属性与范式演进、高质量数据集建设、知识产权情报的学科体系、大语言模型在科技文献分析中的应用、数字人文中的语义表征问题等关键方向。与会专家指出,面对从“图书情报与档案管理”向“信息资源管理”乃至“数字文明”的学科转型,青年学者既迎来研究疆域的拓展,也面临学术身份与学科方向的深层拷问。在技术洪流奔腾的今天,论坛不仅搭建了学术交流的平台,更激发了对学科本质与未来路径的深刻反思。 展开更多
关键词 信息资源管理 图书情报与档案管理 学科更名 数据集 大语言模型 数字人文 语义表征
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SMD残留检测的ELISA方法的建立和初步应用 被引量:15
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作者 周新民 陈连颐 +1 位作者 王捍东 王宗元 《畜牧与兽医》 北大核心 2003年第10期8-11,共4页
用戊二醛法将SMD与载体蛋白BSA偶联 ,制备合成抗原SMD BSA作免疫原 ,同法合成包被抗原SMD OVA ,免疫健康家兔获得抗血清。分别用双向琼脂扩散试验和ELISA试验对抗血清进行定性定量测定 ,结果表明所获抗血清特异性针对SMD。用所制备的抗... 用戊二醛法将SMD与载体蛋白BSA偶联 ,制备合成抗原SMD BSA作免疫原 ,同法合成包被抗原SMD OVA ,免疫健康家兔获得抗血清。分别用双向琼脂扩散试验和ELISA试验对抗血清进行定性定量测定 ,结果表明所获抗血清特异性针对SMD。用所制备的抗血清建立间接竞争ELISA方法。优化了ELISA的工作条件 ,方阵测定确定了包被抗原最佳浓度 (50 μg/mL) ,抗血清最佳稀释度 (1∶1 0 0 ) ,酶标抗体的最适工作稀释度 (1∶50 0 ) ,并建立了ELISA标准工作曲线。工作曲线表明在 1 0~ 2 0 0 0 μg/L浓度范围内呈良好的线性关系。该法检测底限为 63μg/L,低于国际规定残留限量 (1 0 0 μg/kg)和国内规定残留限量 (30 0 μg/kg)的要求。 展开更多
关键词 smd 药物残留 残留检测 ELISA 磺胺对甲氧嘧啶 人工抗原 血清抗体
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SMD单克隆抗体的制备及测定方法的建立 被引量:11
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作者 彭会建 王捍东 +2 位作者 王宗元 唐娜 周晓昕 《畜牧与兽医》 北大核心 2003年第9期12-14,共3页
用戊二醛作为偶联剂 ,将磺胺对甲氧嘧啶 (SMD )与牛血清白蛋白 (BSA )或卵清蛋白 (OVA)偶联形成完全抗原 ,经紫外分光光度计扫描鉴定。以人工抗原免疫BALB/c小鼠 ,取脾细胞与骨髓瘤细胞 (SP2 /0 -Ag1 4)融合 ,用间接ELISA联合竞争ELISA... 用戊二醛作为偶联剂 ,将磺胺对甲氧嘧啶 (SMD )与牛血清白蛋白 (BSA )或卵清蛋白 (OVA)偶联形成完全抗原 ,经紫外分光光度计扫描鉴定。以人工抗原免疫BALB/c小鼠 ,取脾细胞与骨髓瘤细胞 (SP2 /0 -Ag1 4)融合 ,用间接ELISA联合竞争ELISA法筛选出产生针对SMD抗体的杂交瘤细胞。经克隆 ,得到 3株特异性好的阳性杂交瘤细胞 ,注入小鼠腹腔产生腹水。建立了测定SMD的ELISA法 ,其检测下限小于5ng/mL。 展开更多
关键词 smd单克隆抗体 制备 测定方法 磺胺对甲氧嘧啶 牛血清白蛋白 完全抗原 杂交瘤细胞 ELISA 间接酶联免疫吸附试验 磺胺类药物 残留检测
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心肌及传导组织内3种蛋白的变化与SMDS的相关性 被引量:3
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作者 罗斌 罗质人 +7 位作者 汪冠三 何韵 唐双柏 张斌 林俊莲 许心舒 宋一璇 毕启明 《中国法医学杂志》 CSCD 2004年第6期340-343,共4页
目的 观察心肌及传导组织内肌动蛋白、血浆白蛋白及纤维连接蛋白的染色变化,探讨青壮年猝死综合征(SMDS)死后诊断的新方法。方法 应用免疫组化S-P法,对SMDS及冠心病猝死者心肌及传导系统内肌动蛋白、血浆白蛋白和纤维连接蛋白的进行... 目的 观察心肌及传导组织内肌动蛋白、血浆白蛋白及纤维连接蛋白的染色变化,探讨青壮年猝死综合征(SMDS)死后诊断的新方法。方法 应用免疫组化S-P法,对SMDS及冠心病猝死者心肌及传导系统内肌动蛋白、血浆白蛋白和纤维连接蛋白的进行染色观察。结果 22例SMDS例猝死者心肌及传导系统内的肌动蛋白缺染17例;血浆白蛋白染色阳性18例;纤维连接蛋白染色阳性15例。并发现在SMDS中,8例有CCS严重病变。结论 心肌及传导系统内血浆蛋白、肌动蛋白改变与SMDS密切相关,部分SMDS病例死前存在早期心肌缺血或梗死的改变。 展开更多
关键词 心肌 smdS 组织内 血浆白蛋白 肌动蛋白 纤维连接蛋白 传导系统 目的观 结论 变化
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SMD缺陷检测中快速图像匹配算法研究 被引量:6
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作者 程良伦 江伟欢 《计算机应用与软件》 CSCD 2010年第11期117-120,共4页
传统灰度归一化互相关匹配算法存在匹配时间太长及不适合旋转情况匹配的缺点。提出改进的层叠二分互相关匹配算法,通过将图像多次缩小一半后进行粗匹配,再依次返回到缩小之前的图像上进行小范围的精匹配来减小匹配时间;并提出旋转搜索... 传统灰度归一化互相关匹配算法存在匹配时间太长及不适合旋转情况匹配的缺点。提出改进的层叠二分互相关匹配算法,通过将图像多次缩小一半后进行粗匹配,再依次返回到缩小之前的图像上进行小范围的精匹配来减小匹配时间;并提出旋转搜索窗口的方法来使算法适合旋转的匹配;通过使用增量法计算互相关值来进一步减小匹配时间;最后研究了改进的算法在SMD缺陷检测中的应用并进行实验测试,结果表明算法能够快速准确检测元件的位置偏移和角度偏转。 展开更多
关键词 归一化互相关 层叠二分 图像匹配 旋转匹配 smd缺陷检测
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抗SmD1抗体在诊断系统性红斑狼疮中的意义 被引量:6
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作者 孙乐栋 钟彩梅 +3 位作者 贺凤姣 曾抗 周再高 黄良 《中国皮肤性病学杂志》 CAS 北大核心 2009年第6期330-331,共2页
目的了解抗SmD1抗体在诊断系统性红斑狼疮(SLE)中的特异性和感敏性,探讨其在SLE诊断中的意义。方法取120例SLE患者和230例非SLE患者的血清,并同时进行抗核抗体(间接免疫荧光法)、抗Sm抗体(免疫斑点法)、抗DNA抗体及抗SmD1抗体(免疫印迹... 目的了解抗SmD1抗体在诊断系统性红斑狼疮(SLE)中的特异性和感敏性,探讨其在SLE诊断中的意义。方法取120例SLE患者和230例非SLE患者的血清,并同时进行抗核抗体(间接免疫荧光法)、抗Sm抗体(免疫斑点法)、抗DNA抗体及抗SmD1抗体(免疫印迹法)检测,统计分析其对SLE患者诊断的特异性与敏感性。结果SLE患者抗SmD1抗体的敏感性为69.17%,特异性为97.82%。结论抗SmD1抗体特异性和敏感性均较高,可作为诊断SLE的参考指标,对SLE的诊断具有重要意义。 展开更多
关键词 smd1抗体 红斑狼疮 系统性 自身抗体
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抗SmD1抗体对系统性红斑狼疮诊断的临床意义 被引量:8
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作者 高小平 陈艳君 +2 位作者 赵宝霞 宋来玉 孙文平 《中国微生态学杂志》 CAS CSCD 2016年第5期548-549,554,共3页
目的探讨抗SmD1抗体的测定对系统性红斑狼疮(SLE)诊断的临床意义。方法用免疫学方法分别检测SLE患者90例、非SLE病例对照组患者100例及健康对照组患者70例血清中的自身抗体。抗SmD1抗体的检测用ELISA方法;抗Sm抗体、抗双链DNA(dsDNA)抗... 目的探讨抗SmD1抗体的测定对系统性红斑狼疮(SLE)诊断的临床意义。方法用免疫学方法分别检测SLE患者90例、非SLE病例对照组患者100例及健康对照组患者70例血清中的自身抗体。抗SmD1抗体的检测用ELISA方法;抗Sm抗体、抗双链DNA(dsDNA)抗体、抗核小体抗体(ANuA)的检测用免疫印迹法。结果 SLE组患者血清中抗SmD1抗体阳性率为75.6%;抗ANuA抗体阳性率为56.7%;抗Sm抗体的阳性率为24.4%;抗dsDNA抗体阳性率为47.8%。SmD1抗体阳性率明显高于ANuA抗体、Sm抗体及dsDNA抗体,差异有统计学意义(P<0.05),且抗SmD1抗体的特异性为98.2%。结论与传统的检测指标比较,抗SmD1抗体具有较高的敏感性和特异性,可作为诊断SLE的一项重要的特异性检测指标。 展开更多
关键词 系统性红斑狼疮 自身抗体 smd1 特异性抗体
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抗SmD1抗体测定对系统性红斑狼疮的诊断意义 被引量:6
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作者 段京明 李茂胜 +2 位作者 李志军 李季青 谢长好 《蚌埠医学院学报》 CAS 2006年第3期255-257,共3页
目的:了解抗SmD1抗体对系统性红斑狼疮(system ic lupus erythem atosus,SLE)诊断的特异性与敏感性,探讨血清抗SmD1抗体水平与SLE病情的关联性。方法:将137例确诊为SLE患者和75例非SLE患者先采用线性印迹法定性检测SmD1。阳性者再采用EL... 目的:了解抗SmD1抗体对系统性红斑狼疮(system ic lupus erythem atosus,SLE)诊断的特异性与敏感性,探讨血清抗SmD1抗体水平与SLE病情的关联性。方法:将137例确诊为SLE患者和75例非SLE患者先采用线性印迹法定性检测SmD1。阳性者再采用ELASA法作定量分析,统计分析抗SmD1抗体对SLE诊断的特异性与敏感性以及与患者临床表现、实验室检查、病情活动性的关系。结果:线性印迹法检测抗SmD1抗体敏感性为84.9%,特异性为96.0%。抗SmD1抗体定量与系统性红斑狼疮病情活动积分呈正相关关系(P<0.01)。结论:线性印迹法检测抗SmD1抗体敏感性和特异性均较高,可作为诊断SLE的参考指标。抗SmD1抗体定量对判断SLE病情活动有一定的参考价值。 展开更多
关键词 红斑狼疮 系统性 smd1抗体 线性印迹法
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巴氏毕赤酵母SMD1168表达人溶菌酶的发酵条件 被引量:8
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作者 夏杰 徐殿胜 +2 位作者 陆兵 安米 张华 《华东理工大学学报(自然科学版)》 CAS CSCD 北大核心 2003年第4期367-371,共5页
研究用毕赤酵母SMD1168菌株(MutS,HIS4+)表达人溶菌酶(HLZ)的发酵条件。此菌株具有对胞外分泌的外源蛋白不降解、对反应器氧传递效率的限制不敏感的特性,有利于在常规反应器条件下的过程放大。在培养基中添加复合维生素,在流加甲醇溶液... 研究用毕赤酵母SMD1168菌株(MutS,HIS4+)表达人溶菌酶(HLZ)的发酵条件。此菌株具有对胞外分泌的外源蛋白不降解、对反应器氧传递效率的限制不敏感的特性,有利于在常规反应器条件下的过程放大。在培养基中添加复合维生素,在流加甲醇溶液中添加山梨醇或甘露醇可维持细胞正常的生长和代谢,并表达高活性的HLZ。采用恒溶解氧的方式流加甘油溶液以提高细胞密度,在一段时间内使细胞处于碳源半饥饿状态后,使用恒速流加甲醇溶液诱导HLZ表达。HLZ的体积生成速率达到9.6mg/(L·h)左右,上清液中HLZ的含量约为1.6g/L,发酵周期为110h。 展开更多
关键词 巴氏毕赤酵母 smd1168 人溶菌酶 流加 发酵
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