BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram ...BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.展开更多
Objective:Near vision loss(NVL)is one of the leading causes of visual impairment worldwide,exerting a profound impact on individual quality of life and socio-economic development.This study aims to analyze the burden ...Objective:Near vision loss(NVL)is one of the leading causes of visual impairment worldwide,exerting a profound impact on individual quality of life and socio-economic development.This study aims to analyze the burden of NVL in China by sex and age groups from 1990 to 2021 and to project trends over the next 15 years.Methods:Using data from the Global Burden of Disease(GBD)2021 database,we conducted descriptive analyses of NVL prevalence in China,calculated age-standardized prevalence rates(ASPR)and age-standardized disability-adjusted life years rates(ASDR)to compare burden differences between sexes and age groups,and applied an autoregressive integrated moving average(ARIMA)model to predict NVL trends for the next 15 years.The model selection was based on best-fit criteria to ensure reliable projections.Results:From 1990 to 2021,China’s ASPR of NVL rose from 10096.24/100000 to 15624.54/100000,and ASDR increased from 101.75/100000 to 158.75/100000.In 2021,ASPR(16551.70/100000)and ASDR(167.69/100000)were higher among females than males(14686.21/100000 and 149.76/100000,respectively).China ranked highest globally in both NVL cases and disability-adjusted life years(DALYs),with female burden significantly exceeding male burden.Projections indicated this trend and sex gap will persist until 2036.Compared with 1990,the prevalence cases and DALYs increased by 239.20%and 238.82%,respectively in 2021,with the highest burden among females and the 55−59 age group.The ARIMA model predicted continued increases in prevalence and DALYs by 2036,with females maintaining a higher burden than males.Conclusion:This study reveals a marked increase in the NVL burden in China and predicts continued growth in the coming years.Public health policies should prioritize NVL prevention and control,with special attention to women and middle-aged populations to mitigate long-term societal and health impacts.展开更多
The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,...The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.展开更多
Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)d...Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)databases.This study aims to establish a best-practice methodological framework,referred to as BRIDGE,to guide the construction of ICWM databases using EHRs.Methods:We developed the methodological framework through a comprehensive process,including systematic literature review,synthesis of empirical experiences,thematic expert discussions,and consultation with an external panel to reach consensus.Results:The BRIDGE framework outlines 6 core components for ICWM-EHR database development:Overall design,database architecture,data extraction and linkage,data governance,data verification,and data quality evaluation.Key data elements include variables related to study population,treatment or exposure,outcomes,and confounders.These databases support various research applications,particularly in evaluating the effectiveness and safety of integrative therapies.To demonstrate its practical value,we developed an ICWM-EHR database on women’s reproductive lifespan,encompassing 2,064,482 patients.This database captures women’s health conditions across the life course,from reproductive age to older adulthood.Conclusions:The BRIDGE methodological framework provides a standardized approach to building high-quality ICWM-EHR databases.It offers a unique opportunity to strengthen the methodological rigor and real-world relevance of Chinese medicine research in integrated healthcare settings.展开更多
The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,...The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.展开更多
AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FAO.It embodie...AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FAO.It embodies continued publications,documents,corpuses,books,technology reports,patents,maps,meeting papers,and other literatures,which are collected by 135 countries and regions,146 branches of AGRIS,and 22 international organizations.Its content comprises all the agricultural fields in the world,as well as forestry,economy,aquatic sciences,fishery,human dietetics,and so on.This database is an international intelligence communication system maintained by FAO,which updates quarterly and increases by 0.13 million records annually,with large data amount.展开更多
A distinctive feature of scholarly communities today is exploring topics and concepts in interdisciplinary and international contexts. This observation is increasingly apparent and visible in advancing our thinking an...A distinctive feature of scholarly communities today is exploring topics and concepts in interdisciplinary and international contexts. This observation is increasingly apparent and visible in advancing our thinking and policies related to human/environmental worlds at local, regional, and global scales. Maps are an important part of these innovative and ongoing research approaches. In this context, we consider urban forests a topic meriting more attention of scholars studying the geographic and environmental intersections of the natural sciences with the social sciences and humanities. We construct two innovative knowledge bases, one a conceptual framework based on major themes and concepts related to mapping urban forests using key words of the first 100 results of a Google Scholar query and a second using the number of Google Scholar hyperlinks about mapping urban forests in 244 capital cities. We discovered that the constructed world maps reveal vast global unevenness in our knowledge about urban forests in hyperlink numbers and ratios, results that merit further attention by disciplinary, international and interdisciplinary scholarly communities.展开更多
Countries worldwide are leveraging the 2030 Agenda and its 17 Sustainable Development Goals(SDGs)for build-ing a more resilient and sustainable future.One solution in this endeavour is transitioning towards a bioecono...Countries worldwide are leveraging the 2030 Agenda and its 17 Sustainable Development Goals(SDGs)for build-ing a more resilient and sustainable future.One solution in this endeavour is transitioning towards a bioeconomy(BE),utilizing renewable resources and low-carbon value chains to meet food,energy,and materials demands.However,BE is neither inherently circular nor sustainable,compromising SDGs’progress.Therefore,we con-ducted a detailed ex-post analysis using correlation,transfer entropy,and network analysis to understand the complex causal interactions between BE and SDGs.Moving beyond correlation,we explored the directional in-fluence of interactions within the BE-SDG nexus.Our findings reveal a robust bidirectional influence between 19 BE criteria and 109 SDG targets across all goals among 48 European countries.While BE can drive progress to-ward SDGs,a balanced distribution of synergies and trade-offs constrains its impact.Collaborative efforts among European countries would effectively drive towards achieving both BE and SDGs.SDG 13 has positive influences from lowered fossil fuel emissions and negative ones due to land use changes and intensified agriculture,which releases stored carbon.Similarly,SDG 15 emerges as a positive influence,as healthy ecosystem services foster a resilient BE.Despite efforts towards SDG 12,Europe’s unsustainable consumption impedes BE supply chains.While BE practices are intended to accelerate sustainability,they fall short of playing a transformational role in achieving the SDGs.A shift towards a cohesive,collaborative strategy that leverages synergies and mitigates trade-offs can enhance the BE’s impact,advancing Europe closer to achieving the 2030 Agenda.展开更多
In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics.Similarities and variations of components present significant analytical challenges.A two-dimensional(2...In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics.Similarities and variations of components present significant analytical challenges.A two-dimensional(2D)liquid chromatography-mass spectrometry(LC-MS)method was established for screening and comprehensive profiling of compositions of the antibiotic colistimethate sodium(CMS).A high concentration of phosphate buffer mobile phase was used in the first-dimensional LC system to get the components well separated.For efficient and high-accuracy screening of CMS,a targeted method based on a self-constructed high resolution(HR)mass spectrum database of CMS components was established.The database was built based on the commercial MassHunter Personal Compound Database and Library(PCDL)software and its accuracy of the compound matching result was verified with six known components before being applied to genuine sample screening.On this basis,the unknown peaks in the CMS chromatograms were deduced and assigned.The molecular formula,group composition,and origins of a total of 99 compounds,of which the combined area percentage accounted for more than 95%of CMS components,were deduced by this 2D-LC-MS method combined with the MassHunter PCDL.This profiling method was highly efficient and could distinguish hundreds of components within 3 h,providing reliable results for quality control of this kind of complex drugs.展开更多
Research into metamorphism plays a pivotal role in reconstructing the evolution of continent,particularly through the study of ancient rocks that are highly susceptible to metamorphic alterations due to multiple tecto...Research into metamorphism plays a pivotal role in reconstructing the evolution of continent,particularly through the study of ancient rocks that are highly susceptible to metamorphic alterations due to multiple tectonic activities.In the big data era,the establishment of new data platforms and the application of big data methods have become a focus for metamorphic rocks.Significant progress has been made in creating specialized databases,compiling comprehensive datasets,and utilizing data analytics to address complex scientific questions.However,many existing databases are inadequate in meeting the specific requirements of metamorphic research,resulting from a substantial amount of valuable data remaining uncollected.Therefore,constructing new databases that can cope with the development of the data era is necessary.This article provides an extensive review of existing databases related to metamorphic rocks and discusses data-driven studies in this.Accordingly,several crucial factors that need to be taken into consideration in the establishment of specialized metamorphic databases are identified,aiming to leverage data-driven applications to achieve broader scientific objectives in metamorphic research.展开更多
Frontiers of Nursing is a nursing academic journal,CN 14-1395/R,ISSN 2097-5368.Size A4,quarterly publication,color printing,public offerings at home and abroad which is managed by the First Hospital of Shanxi Medical ...Frontiers of Nursing is a nursing academic journal,CN 14-1395/R,ISSN 2097-5368.Size A4,quarterly publication,color printing,public offerings at home and abroad which is managed by the First Hospital of Shanxi Medical University,sponsored by Shanxi Nursing Association and Shanxi Medical Periodical Press Co.,Ltd.Frontiers of Nursing has been indexed by databases including Scopus,Google Scholar,DOAJ,Baidu Scholar,CNKI,VIP,Wanfang,Chaoxing,and so on.展开更多
BACKGROUND For locally advanced gallbladder cancer,previous clinical studies have demon-strated that chemotherapy results in significant survival benefits when compared to surgery alone.However,data demonstrating a si...BACKGROUND For locally advanced gallbladder cancer,previous clinical studies have demon-strated that chemotherapy results in significant survival benefits when compared to surgery alone.However,data demonstrating a similar survival benefit with early-stage gallbladder cancer is limited.This study seeks to evaluate the impact chemotherapy has on survival in patients with early-stage gallbladder cancer using a large,multi-institution database.AIM To investigate the survival benefit of chemotherapy in patients with stage II gallbladder cancer.METHODS We performed a retrospective multivariable analysis of the National Cancer Database from 2010 to 2017 to evaluate the effect that chemotherapy has on the survival of patients with stage II gallbladder cancer.Our objective was to de-termine if there were any statistically significant survival differences between those who received surgery and chemotherapy vs those who only underwent surgery.RESULTS Of the 899 patients with stage II gallbladder cancer,328 patients had undergone chemotherapy and surgery.The average overall survival for those who had surgery and chemotherapy vs only surgery was 52.6 months and 51.1 months,respectively.This difference was not statistically significant(P=0.2).In the secondary analysis,the surgical group who had a liver resection had better overall survival(P<0.0001).CONCLUSION Practitioners should carefully consider chemotherapy for early-stage gallbladder cancer,as risks may outweigh survival benefits,and surgeons should also consider liver resections as part of their surgical management.展开更多
When interpreting results,it is imperative to have some understanding of the degree to which the results are replicable.If the results cannot be replicated with independent data,then interpretations from the results b...When interpreting results,it is imperative to have some understanding of the degree to which the results are replicable.If the results cannot be replicated with independent data,then interpretations from the results become questionable.To minimize the potential for misinterpretations,the current study analyzes six time-series derived from globally sampled U-Pb zircon databases–of which,two are independent igneous databases,one being a quasi-independent igneous database,and three being independent detrital databases.These time-series are then analyzed with standard statistical methods to evaluate replicability.The methods include bandpass filtering to transform the raw time-series into stationary sequences,Student’s t-test,Monte Carlo simulations,periodograms from spectral analysis,correlation studies,and correlograms.Each test is designed to determine the replicability of a specific time-series,as well as the replicability of periodicities found from the time-series.The results show at least three key components to assessing replicability:(a)U-Pb igneous and detrital zircon age distributions are highly replicable,(b)time-series replicability gradually deteriorates with age,and(c)replicability is scale dependent,with low frequency cycles being more replicable than high frequency cycles.From the tests,we conclude that four harmonic cycles are highly replicable and statistically significant,these being periodicities of 810,270,90,and 67.5-myr.展开更多
Natural products(NPs)have long held a significant position in various fields such as medicine,food,agriculture,and materials.The chemical space covered by NPs is extensive but often underexplored.Therefore,high-throug...Natural products(NPs)have long held a significant position in various fields such as medicine,food,agriculture,and materials.The chemical space covered by NPs is extensive but often underexplored.Therefore,high-throughput and efficient methodologies for the annotation and discovery of NPs are desired to address the complexity and diversity of NP-based systems.Mass spectrometry(MS)has emerged as a powerful platform for the annotation and discovery of NPs.MS databases provide vital support for the structural characterization of NPs by integrating extensive mass spectral data and sample information.Additionally,the released annotation methodologies,based on a variety of informatics tools,continuously improve the ability to annotate the structure and properties of compounds.This review examines the current mainstream databases and annotation methodologies,focusing on their advantages and limitations.Prospects for future technological advancements are then discussed in terms of novel applications and research objectives.Through a systematic overview,this review aims to provide valuable insights and a reference for MS-based NPs annotation,thereby promoting the discovery of novel natural entities.展开更多
Mg-Zn-Mn alloys have the advantages of low cost,excellent mechanical properties,and high corrosion resistance.To clarify the phase equilibria of Mg-Zn-Mn alloy in the Mg-rich corners,the present work experimentally in...Mg-Zn-Mn alloys have the advantages of low cost,excellent mechanical properties,and high corrosion resistance.To clarify the phase equilibria of Mg-Zn-Mn alloy in the Mg-rich corners,the present work experimentally investigated the phase equilibria in the Mg-rich corner at 300-400°C with equilibrated alloy method using electron probe micro analyzer(EPMA),X-ray diffractometer(XRD),transmission electron microscopy(TEM),and differential scanning calorimeter(DSC).Mn atoms were found to dissolve into MgZn_(2) to form a ternary solid-solution type compound,in which Mn content can be up to 15.1at%at 400°C.Three-phase equilibrium ofα-Mg+MgZn_(2)+α-Mn and liquid+α-Mg+MgZn_(2) were confirmed at 400°C.Subsequently,thermodynamic modeling of the Mg-Zn-Mn system was carried out using the CALPHAD method based on the experimental data of this work and literature data.The calculated invariant reaction Liquid+α-Mn→α-Mg+MgZn_(2) at 430°C shows good agreement with the DSC results.In addition,the results of solidification path calculations explain the microstructure in the ascast and annealed alloys well.The agreement between the calculated results and experimental data proves the self-consistency of the thermodynamic database,which can provide guidance for the compositional design of Mg-Zn-Mn alloys.展开更多
Frontiers of Nursing is a nursing academic journal,CN 14-1395/R,ISSN 2097-5368.Size A4,quarterly publication,color printing,public offerings at home and abroad which is managed by the First Hospital of Shanxi Medical ...Frontiers of Nursing is a nursing academic journal,CN 14-1395/R,ISSN 2097-5368.Size A4,quarterly publication,color printing,public offerings at home and abroad which is managed by the First Hospital of Shanxi Medical University,sponsored by Shanxi Nursing Association and Shanxi Medical Periodical Press Co.,Ltd.Frontiers of Nursing has been indexed by databases including Scopus,Google Scholar,DOAJ,Baidu Scholar,CNKI,VIP,Wanfang,Chaoxing,and so on.展开更多
Background:It is widely accepted that an alteration in lipid metabolism can serve as an essential hallmark for the growth and progression of various malignancies.However,the potential of lipid metabolism genes(LMGs)an...Background:It is widely accepted that an alteration in lipid metabolism can serve as an essential hallmark for the growth and progression of various malignancies.However,the potential of lipid metabolism genes(LMGs)and related pathways as drug targets for rectal adenocarcinoma(READ)treatment and prognostic evaluation requires further investigation.The objective of the present study was to construct a prognostic prediction model for READ based on LMGs,and to evaluate its performance.Methods:The RNA-seq FPKM data and clinical data from READ patients and normal rectal tissues were downloaded from The Cancer Genome Atlas database.The LMGs were acquired from the Molecular Signatures Database.Subsequently,LMGs associated with the prognosis of READ were screened,and these genes were used to construct a prognostic prediction model for READ patients.The model was then subjected to rigorous evaluation.Furthermore,immune infiltration and limma analyses were performed in different clusters,and pathway enrichment analyses were performed on the screened differentially expressed genes(DEGs).Results:A prognostic prediction model was constructed based on 5 LMGs(PLA2G2F,CBR1,CHKB,ETNPPL,and ARV1)to classify READ into high-and low-risk groups,with the low-risk group exhibiting a higher survival rate.Consequently,the prognostic model demonstrated notable predictive capability.A total of 139 DEGs were identified,38 of which were identified as being upregulated and 101 as being downregulated.Furthermore,a comparison of the immune microenvironment and immune pathways between the low-and high-risk groups revealed significant disparities.Conclusions:Predictive models based on 5 lipid metabolism DEGs effectively predicted the prognosis of READ patients.Moreover,these 5 LMGs have potential as molecular biomarkers and therapeutic targets for READ patients.展开更多
基金Supported by the Appropriate Technology Promotion Program in Chongqing,No.2023jstg005.
文摘BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.
基金supported by the Natural Science Foundation of Hunan Province(2023JJ30817)Hunan Provincial Natural Science Foundation-Hengyang City Joint Fund Project(2025JJ70129)+1 种基金Changsha Natural Science Foundation(kq2403057)China。
文摘Objective:Near vision loss(NVL)is one of the leading causes of visual impairment worldwide,exerting a profound impact on individual quality of life and socio-economic development.This study aims to analyze the burden of NVL in China by sex and age groups from 1990 to 2021 and to project trends over the next 15 years.Methods:Using data from the Global Burden of Disease(GBD)2021 database,we conducted descriptive analyses of NVL prevalence in China,calculated age-standardized prevalence rates(ASPR)and age-standardized disability-adjusted life years rates(ASDR)to compare burden differences between sexes and age groups,and applied an autoregressive integrated moving average(ARIMA)model to predict NVL trends for the next 15 years.The model selection was based on best-fit criteria to ensure reliable projections.Results:From 1990 to 2021,China’s ASPR of NVL rose from 10096.24/100000 to 15624.54/100000,and ASDR increased from 101.75/100000 to 158.75/100000.In 2021,ASPR(16551.70/100000)and ASDR(167.69/100000)were higher among females than males(14686.21/100000 and 149.76/100000,respectively).China ranked highest globally in both NVL cases and disability-adjusted life years(DALYs),with female burden significantly exceeding male burden.Projections indicated this trend and sex gap will persist until 2036.Compared with 1990,the prevalence cases and DALYs increased by 239.20%and 238.82%,respectively in 2021,with the highest burden among females and the 55−59 age group.The ARIMA model predicted continued increases in prevalence and DALYs by 2036,with females maintaining a higher burden than males.Conclusion:This study reveals a marked increase in the NVL burden in China and predicts continued growth in the coming years.Public health policies should prioritize NVL prevention and control,with special attention to women and middle-aged populations to mitigate long-term societal and health impacts.
文摘The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.
基金supported by the National Key Research&Development Program of China(No.2024YFC3505800)the National Natural Science Foundation of China(Nos.82474334,82474335 and 72174132)+3 种基金National Science Fund for Distinguished Young Scholars(No.82225049)the Key Research&Development Projects of Sichuan Provincial Department of Science and Technology(Nos.2024YFFK0174 and 2024YFFK0152)1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYYC24010 and ZYGD23004)the Special Fund for Traditional Chinese Medicine of Sichuan Provincial Administration of Traditional Chinese Medicine(No.2024zd023).
文摘Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)databases.This study aims to establish a best-practice methodological framework,referred to as BRIDGE,to guide the construction of ICWM databases using EHRs.Methods:We developed the methodological framework through a comprehensive process,including systematic literature review,synthesis of empirical experiences,thematic expert discussions,and consultation with an external panel to reach consensus.Results:The BRIDGE framework outlines 6 core components for ICWM-EHR database development:Overall design,database architecture,data extraction and linkage,data governance,data verification,and data quality evaluation.Key data elements include variables related to study population,treatment or exposure,outcomes,and confounders.These databases support various research applications,particularly in evaluating the effectiveness and safety of integrative therapies.To demonstrate its practical value,we developed an ICWM-EHR database on women’s reproductive lifespan,encompassing 2,064,482 patients.This database captures women’s health conditions across the life course,from reproductive age to older adulthood.Conclusions:The BRIDGE methodological framework provides a standardized approach to building high-quality ICWM-EHR databases.It offers a unique opportunity to strengthen the methodological rigor and real-world relevance of Chinese medicine research in integrated healthcare settings.
文摘The journal of Meteorological and Environmental Research[ISSN:2152-3940]has been included and stored by the following famous databases:CA,CABI,CSA,EBSCO,UPD,AGRIS,EA,Chinese Science and Technology Periodical Database,and CNKI,as well as Library of Congress,United States.
文摘AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FAO.It embodies continued publications,documents,corpuses,books,technology reports,patents,maps,meeting papers,and other literatures,which are collected by 135 countries and regions,146 branches of AGRIS,and 22 international organizations.Its content comprises all the agricultural fields in the world,as well as forestry,economy,aquatic sciences,fishery,human dietetics,and so on.This database is an international intelligence communication system maintained by FAO,which updates quarterly and increases by 0.13 million records annually,with large data amount.
文摘A distinctive feature of scholarly communities today is exploring topics and concepts in interdisciplinary and international contexts. This observation is increasingly apparent and visible in advancing our thinking and policies related to human/environmental worlds at local, regional, and global scales. Maps are an important part of these innovative and ongoing research approaches. In this context, we consider urban forests a topic meriting more attention of scholars studying the geographic and environmental intersections of the natural sciences with the social sciences and humanities. We construct two innovative knowledge bases, one a conceptual framework based on major themes and concepts related to mapping urban forests using key words of the first 100 results of a Google Scholar query and a second using the number of Google Scholar hyperlinks about mapping urban forests in 244 capital cities. We discovered that the constructed world maps reveal vast global unevenness in our knowledge about urban forests in hyperlink numbers and ratios, results that merit further attention by disciplinary, international and interdisciplinary scholarly communities.
基金funding from the German Federal Ministry of Ed-ucation and Research(BMBF)for the BIOCLIMAPATHS project(Grant No.01LS1906A)under the Axis-ERANET callfunding from the European Research Council(ERC)Starting Grant 2022 for the BEYONDSDG project(Grant No.101077492)。
文摘Countries worldwide are leveraging the 2030 Agenda and its 17 Sustainable Development Goals(SDGs)for build-ing a more resilient and sustainable future.One solution in this endeavour is transitioning towards a bioeconomy(BE),utilizing renewable resources and low-carbon value chains to meet food,energy,and materials demands.However,BE is neither inherently circular nor sustainable,compromising SDGs’progress.Therefore,we con-ducted a detailed ex-post analysis using correlation,transfer entropy,and network analysis to understand the complex causal interactions between BE and SDGs.Moving beyond correlation,we explored the directional in-fluence of interactions within the BE-SDG nexus.Our findings reveal a robust bidirectional influence between 19 BE criteria and 109 SDG targets across all goals among 48 European countries.While BE can drive progress to-ward SDGs,a balanced distribution of synergies and trade-offs constrains its impact.Collaborative efforts among European countries would effectively drive towards achieving both BE and SDGs.SDG 13 has positive influences from lowered fossil fuel emissions and negative ones due to land use changes and intensified agriculture,which releases stored carbon.Similarly,SDG 15 emerges as a positive influence,as healthy ecosystem services foster a resilient BE.Despite efforts towards SDG 12,Europe’s unsustainable consumption impedes BE supply chains.While BE practices are intended to accelerate sustainability,they fall short of playing a transformational role in achieving the SDGs.A shift towards a cohesive,collaborative strategy that leverages synergies and mitigates trade-offs can enhance the BE’s impact,advancing Europe closer to achieving the 2030 Agenda.
基金support from the Science Research Program Project for Drug Regulation,Jiangsu Medical Products Administration,China(Grant No.:202207)the National Drug Standards Revision Project,China(Grant No.:2023Y41)+1 种基金the National Natural Science Foundation of China(Grant No.:22276080)the Foreign Expert Project,China(Grant No.:G2022014096L).
文摘In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics.Similarities and variations of components present significant analytical challenges.A two-dimensional(2D)liquid chromatography-mass spectrometry(LC-MS)method was established for screening and comprehensive profiling of compositions of the antibiotic colistimethate sodium(CMS).A high concentration of phosphate buffer mobile phase was used in the first-dimensional LC system to get the components well separated.For efficient and high-accuracy screening of CMS,a targeted method based on a self-constructed high resolution(HR)mass spectrum database of CMS components was established.The database was built based on the commercial MassHunter Personal Compound Database and Library(PCDL)software and its accuracy of the compound matching result was verified with six known components before being applied to genuine sample screening.On this basis,the unknown peaks in the CMS chromatograms were deduced and assigned.The molecular formula,group composition,and origins of a total of 99 compounds,of which the combined area percentage accounted for more than 95%of CMS components,were deduced by this 2D-LC-MS method combined with the MassHunter PCDL.This profiling method was highly efficient and could distinguish hundreds of components within 3 h,providing reliable results for quality control of this kind of complex drugs.
基金funded by the National Natural Science Foundation of China(No.42220104008)。
文摘Research into metamorphism plays a pivotal role in reconstructing the evolution of continent,particularly through the study of ancient rocks that are highly susceptible to metamorphic alterations due to multiple tectonic activities.In the big data era,the establishment of new data platforms and the application of big data methods have become a focus for metamorphic rocks.Significant progress has been made in creating specialized databases,compiling comprehensive datasets,and utilizing data analytics to address complex scientific questions.However,many existing databases are inadequate in meeting the specific requirements of metamorphic research,resulting from a substantial amount of valuable data remaining uncollected.Therefore,constructing new databases that can cope with the development of the data era is necessary.This article provides an extensive review of existing databases related to metamorphic rocks and discusses data-driven studies in this.Accordingly,several crucial factors that need to be taken into consideration in the establishment of specialized metamorphic databases are identified,aiming to leverage data-driven applications to achieve broader scientific objectives in metamorphic research.
文摘Frontiers of Nursing is a nursing academic journal,CN 14-1395/R,ISSN 2097-5368.Size A4,quarterly publication,color printing,public offerings at home and abroad which is managed by the First Hospital of Shanxi Medical University,sponsored by Shanxi Nursing Association and Shanxi Medical Periodical Press Co.,Ltd.Frontiers of Nursing has been indexed by databases including Scopus,Google Scholar,DOAJ,Baidu Scholar,CNKI,VIP,Wanfang,Chaoxing,and so on.
文摘BACKGROUND For locally advanced gallbladder cancer,previous clinical studies have demon-strated that chemotherapy results in significant survival benefits when compared to surgery alone.However,data demonstrating a similar survival benefit with early-stage gallbladder cancer is limited.This study seeks to evaluate the impact chemotherapy has on survival in patients with early-stage gallbladder cancer using a large,multi-institution database.AIM To investigate the survival benefit of chemotherapy in patients with stage II gallbladder cancer.METHODS We performed a retrospective multivariable analysis of the National Cancer Database from 2010 to 2017 to evaluate the effect that chemotherapy has on the survival of patients with stage II gallbladder cancer.Our objective was to de-termine if there were any statistically significant survival differences between those who received surgery and chemotherapy vs those who only underwent surgery.RESULTS Of the 899 patients with stage II gallbladder cancer,328 patients had undergone chemotherapy and surgery.The average overall survival for those who had surgery and chemotherapy vs only surgery was 52.6 months and 51.1 months,respectively.This difference was not statistically significant(P=0.2).In the secondary analysis,the surgical group who had a liver resection had better overall survival(P<0.0001).CONCLUSION Practitioners should carefully consider chemotherapy for early-stage gallbladder cancer,as risks may outweigh survival benefits,and surgeons should also consider liver resections as part of their surgical management.
基金supported by the French Agence Nationale de la Recherche(19-CE31-0002 AstroMeso)the European Research Council under the European Union’s Horizon 2020 Research and Innovation Program(Advanced Grant AstroGeo-885250).
文摘When interpreting results,it is imperative to have some understanding of the degree to which the results are replicable.If the results cannot be replicated with independent data,then interpretations from the results become questionable.To minimize the potential for misinterpretations,the current study analyzes six time-series derived from globally sampled U-Pb zircon databases–of which,two are independent igneous databases,one being a quasi-independent igneous database,and three being independent detrital databases.These time-series are then analyzed with standard statistical methods to evaluate replicability.The methods include bandpass filtering to transform the raw time-series into stationary sequences,Student’s t-test,Monte Carlo simulations,periodograms from spectral analysis,correlation studies,and correlograms.Each test is designed to determine the replicability of a specific time-series,as well as the replicability of periodicities found from the time-series.The results show at least three key components to assessing replicability:(a)U-Pb igneous and detrital zircon age distributions are highly replicable,(b)time-series replicability gradually deteriorates with age,and(c)replicability is scale dependent,with low frequency cycles being more replicable than high frequency cycles.From the tests,we conclude that four harmonic cycles are highly replicable and statistically significant,these being periodicities of 810,270,90,and 67.5-myr.
基金supported by the National Natural Science Foundation of China(Nos.82274064,82374026,and 82204591)。
文摘Natural products(NPs)have long held a significant position in various fields such as medicine,food,agriculture,and materials.The chemical space covered by NPs is extensive but often underexplored.Therefore,high-throughput and efficient methodologies for the annotation and discovery of NPs are desired to address the complexity and diversity of NP-based systems.Mass spectrometry(MS)has emerged as a powerful platform for the annotation and discovery of NPs.MS databases provide vital support for the structural characterization of NPs by integrating extensive mass spectral data and sample information.Additionally,the released annotation methodologies,based on a variety of informatics tools,continuously improve the ability to annotate the structure and properties of compounds.This review examines the current mainstream databases and annotation methodologies,focusing on their advantages and limitations.Prospects for future technological advancements are then discussed in terms of novel applications and research objectives.Through a systematic overview,this review aims to provide valuable insights and a reference for MS-based NPs annotation,thereby promoting the discovery of novel natural entities.
基金financial support by the National Key Research and Development Program of China(No.2023YFB3809101)the National Natural Science Foundation of China(Nos.52371010 and 52422407)+1 种基金the Science and Technology Committee of Shanghai,China(No.21ZR1423600)the Open Project of State Key Laboratory of Baiyunobo Rare Earth Resources Researches and Comprehensive Utilization,China.
文摘Mg-Zn-Mn alloys have the advantages of low cost,excellent mechanical properties,and high corrosion resistance.To clarify the phase equilibria of Mg-Zn-Mn alloy in the Mg-rich corners,the present work experimentally investigated the phase equilibria in the Mg-rich corner at 300-400°C with equilibrated alloy method using electron probe micro analyzer(EPMA),X-ray diffractometer(XRD),transmission electron microscopy(TEM),and differential scanning calorimeter(DSC).Mn atoms were found to dissolve into MgZn_(2) to form a ternary solid-solution type compound,in which Mn content can be up to 15.1at%at 400°C.Three-phase equilibrium ofα-Mg+MgZn_(2)+α-Mn and liquid+α-Mg+MgZn_(2) were confirmed at 400°C.Subsequently,thermodynamic modeling of the Mg-Zn-Mn system was carried out using the CALPHAD method based on the experimental data of this work and literature data.The calculated invariant reaction Liquid+α-Mn→α-Mg+MgZn_(2) at 430°C shows good agreement with the DSC results.In addition,the results of solidification path calculations explain the microstructure in the ascast and annealed alloys well.The agreement between the calculated results and experimental data proves the self-consistency of the thermodynamic database,which can provide guidance for the compositional design of Mg-Zn-Mn alloys.
文摘Frontiers of Nursing is a nursing academic journal,CN 14-1395/R,ISSN 2097-5368.Size A4,quarterly publication,color printing,public offerings at home and abroad which is managed by the First Hospital of Shanxi Medical University,sponsored by Shanxi Nursing Association and Shanxi Medical Periodical Press Co.,Ltd.Frontiers of Nursing has been indexed by databases including Scopus,Google Scholar,DOAJ,Baidu Scholar,CNKI,VIP,Wanfang,Chaoxing,and so on.
基金supported by the Science and Technology Research Project of the Shandong Geriatrics Society in 2024(No.LKJGG2024W072).
文摘Background:It is widely accepted that an alteration in lipid metabolism can serve as an essential hallmark for the growth and progression of various malignancies.However,the potential of lipid metabolism genes(LMGs)and related pathways as drug targets for rectal adenocarcinoma(READ)treatment and prognostic evaluation requires further investigation.The objective of the present study was to construct a prognostic prediction model for READ based on LMGs,and to evaluate its performance.Methods:The RNA-seq FPKM data and clinical data from READ patients and normal rectal tissues were downloaded from The Cancer Genome Atlas database.The LMGs were acquired from the Molecular Signatures Database.Subsequently,LMGs associated with the prognosis of READ were screened,and these genes were used to construct a prognostic prediction model for READ patients.The model was then subjected to rigorous evaluation.Furthermore,immune infiltration and limma analyses were performed in different clusters,and pathway enrichment analyses were performed on the screened differentially expressed genes(DEGs).Results:A prognostic prediction model was constructed based on 5 LMGs(PLA2G2F,CBR1,CHKB,ETNPPL,and ARV1)to classify READ into high-and low-risk groups,with the low-risk group exhibiting a higher survival rate.Consequently,the prognostic model demonstrated notable predictive capability.A total of 139 DEGs were identified,38 of which were identified as being upregulated and 101 as being downregulated.Furthermore,a comparison of the immune microenvironment and immune pathways between the low-and high-risk groups revealed significant disparities.Conclusions:Predictive models based on 5 lipid metabolism DEGs effectively predicted the prognosis of READ patients.Moreover,these 5 LMGs have potential as molecular biomarkers and therapeutic targets for READ patients.
