Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)d...Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)databases.This study aims to establish a best-practice methodological framework,referred to as BRIDGE,to guide the construction of ICWM databases using EHRs.Methods:We developed the methodological framework through a comprehensive process,including systematic literature review,synthesis of empirical experiences,thematic expert discussions,and consultation with an external panel to reach consensus.Results:The BRIDGE framework outlines 6 core components for ICWM-EHR database development:Overall design,database architecture,data extraction and linkage,data governance,data verification,and data quality evaluation.Key data elements include variables related to study population,treatment or exposure,outcomes,and confounders.These databases support various research applications,particularly in evaluating the effectiveness and safety of integrative therapies.To demonstrate its practical value,we developed an ICWM-EHR database on women’s reproductive lifespan,encompassing 2,064,482 patients.This database captures women’s health conditions across the life course,from reproductive age to older adulthood.Conclusions:The BRIDGE methodological framework provides a standardized approach to building high-quality ICWM-EHR databases.It offers a unique opportunity to strengthen the methodological rigor and real-world relevance of Chinese medicine research in integrated healthcare settings.展开更多
This paper presents a methodology driven by database constraints for designing and developing(database)software applications.Much needed and with excellent results,this paradigm guarantees the highest possible quality...This paper presents a methodology driven by database constraints for designing and developing(database)software applications.Much needed and with excellent results,this paradigm guarantees the highest possible quality of the managed data.The proposed methodology is illustrated with an easy to understand,yet complex medium-sized genealogy software application driven by more than 200 database constraints,which fully meets such expectations.展开更多
1 Introduction Metabolic syndrome(MetS)and its five characteristic diseases(central obesity,type 2 diabetes,hypertension,hypertriglyceridemia,reduced high-density lipoprotein cholesterol)pose a serious threat to human...1 Introduction Metabolic syndrome(MetS)and its five characteristic diseases(central obesity,type 2 diabetes,hypertension,hypertriglyceridemia,reduced high-density lipoprotein cholesterol)pose a serious threat to human health[1].A large number of studies have demonstrated that non-coding RNAs(ncRNAs)are instrumental in the pathogenesis of diseases related to metabolic syndrome[2].Therefore,there is an urgent need to develop a database for storing MetS-associated ncRNAs.展开更多
In order to collect failure data conveniently and reserve reliability research data,the data collection software,the machine tool fault information management system, was developed. The method to computer numerical co...In order to collect failure data conveniently and reserve reliability research data,the data collection software,the machine tool fault information management system, was developed. The method to computer numerical control( CNC) machine tool reliability data collection was introduced. Through designing the form and applying SQL Server 2008 as the database and Visual Studio 2005 as the development platform,establish the database,develop the software based on the early stage work,and realize the comprehensive statistical information, laying the foundation for further data analysis.展开更多
基金supported by the National Key Research&Development Program of China(No.2024YFC3505800)the National Natural Science Foundation of China(Nos.82474334,82474335 and 72174132)+3 种基金National Science Fund for Distinguished Young Scholars(No.82225049)the Key Research&Development Projects of Sichuan Provincial Department of Science and Technology(Nos.2024YFFK0174 and 2024YFFK0152)1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYYC24010 and ZYGD23004)the Special Fund for Traditional Chinese Medicine of Sichuan Provincial Administration of Traditional Chinese Medicine(No.2024zd023).
文摘Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)databases.This study aims to establish a best-practice methodological framework,referred to as BRIDGE,to guide the construction of ICWM databases using EHRs.Methods:We developed the methodological framework through a comprehensive process,including systematic literature review,synthesis of empirical experiences,thematic expert discussions,and consultation with an external panel to reach consensus.Results:The BRIDGE framework outlines 6 core components for ICWM-EHR database development:Overall design,database architecture,data extraction and linkage,data governance,data verification,and data quality evaluation.Key data elements include variables related to study population,treatment or exposure,outcomes,and confounders.These databases support various research applications,particularly in evaluating the effectiveness and safety of integrative therapies.To demonstrate its practical value,we developed an ICWM-EHR database on women’s reproductive lifespan,encompassing 2,064,482 patients.This database captures women’s health conditions across the life course,from reproductive age to older adulthood.Conclusions:The BRIDGE methodological framework provides a standardized approach to building high-quality ICWM-EHR databases.It offers a unique opportunity to strengthen the methodological rigor and real-world relevance of Chinese medicine research in integrated healthcare settings.
文摘This paper presents a methodology driven by database constraints for designing and developing(database)software applications.Much needed and with excellent results,this paradigm guarantees the highest possible quality of the managed data.The proposed methodology is illustrated with an easy to understand,yet complex medium-sized genealogy software application driven by more than 200 database constraints,which fully meets such expectations.
基金supported by the National Natural Science Foundation of China(Grant No.62172128).
文摘1 Introduction Metabolic syndrome(MetS)and its five characteristic diseases(central obesity,type 2 diabetes,hypertension,hypertriglyceridemia,reduced high-density lipoprotein cholesterol)pose a serious threat to human health[1].A large number of studies have demonstrated that non-coding RNAs(ncRNAs)are instrumental in the pathogenesis of diseases related to metabolic syndrome[2].Therefore,there is an urgent need to develop a database for storing MetS-associated ncRNAs.
基金National Science and Technology Major Project of China(No.2013ZX04013-011-05)
文摘In order to collect failure data conveniently and reserve reliability research data,the data collection software,the machine tool fault information management system, was developed. The method to computer numerical control( CNC) machine tool reliability data collection was introduced. Through designing the form and applying SQL Server 2008 as the database and Visual Studio 2005 as the development platform,establish the database,develop the software based on the early stage work,and realize the comprehensive statistical information, laying the foundation for further data analysis.
