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Overview of Data-Driven Models for Wind Turbine Wake Flows
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作者 Maokun Ye Min Li +2 位作者 Mingqiu Liu Chengjiang Xiao Decheng Wan 《哈尔滨工程大学学报(英文版)》 2025年第1期1-20,共20页
With the rapid advancement of machine learning technology and its growing adoption in research and engineering applications,an increasing number of studies have embraced data-driven approaches for modeling wind turbin... With the rapid advancement of machine learning technology and its growing adoption in research and engineering applications,an increasing number of studies have embraced data-driven approaches for modeling wind turbine wakes.These models leverage the ability to capture complex,high-dimensional characteristics of wind turbine wakes while offering significantly greater efficiency in the prediction process than physics-driven models.As a result,data-driven wind turbine wake models are regarded as powerful and effective tools for predicting wake behavior and turbine power output.This paper aims to provide a concise yet comprehensive review of existing studies on wind turbine wake modeling that employ data-driven approaches.It begins by defining and classifying machine learning methods to facilitate a clearer understanding of the reviewed literature.Subsequently,the related studies are categorized into four key areas:wind turbine power prediction,data-driven analytic wake models,wake field reconstruction,and the incorporation of explicit physical constraints.The accuracy of data-driven models is influenced by two primary factors:the quality of the training data and the performance of the model itself.Accordingly,both data accuracy and model structure are discussed in detail within the review. 展开更多
关键词 data-driven Machine learning Artificial neural networks Wind turbine wake Wake models
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Shale gas production evaluation framework based on data-driven models 被引量:8
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作者 You-Wei He Zhi-Yue He +3 位作者 Yong Tang Ying-Jie Xu Ji-Chang Long Kamy Sepehrnoori 《Petroleum Science》 SCIE EI CAS CSCD 2023年第3期1659-1675,共17页
Increasing the production and utilization of shale gas is of great significance for building a clean and low-carbon energy system.Sharp decline of gas production has been widely observed in shale gas reservoirs.How to... Increasing the production and utilization of shale gas is of great significance for building a clean and low-carbon energy system.Sharp decline of gas production has been widely observed in shale gas reservoirs.How to forecast shale gas production is still challenging due to complex fracture networks,dynamic fracture properties,frac hits,complicated multiphase flow,and multi-scale flow as well as data quality and uncertainty.This work develops an integrated framework for evaluating shale gas well production based on data-driven models.Firstly,a comprehensive dominated-factor system has been established,including geological,drilling,fracturing,and production factors.Data processing and visualization are required to ensure data quality and determine final data set.A shale gas production evaluation model is developed to evaluate shale gas production levels.Finally,the random forest algorithm is used to forecast shale gas production.The prediction accuracy of shale gas production level is higher than 95%based on the shale gas reservoirs in China.Forty-one wells are randomly selected to predict cumulative gas production using the optimal regression model.The proposed shale gas production evaluation frame-work overcomes too many assumptions of analytical or semi-analytical models and avoids huge computation cost and poor generalization for numerical modelling. 展开更多
关键词 Shale gas Production evaluation Production prediction data-driven models Carbon neutrality
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Optimization Design of Fairings for VIV Suppression Based on Data-Driven Models and Genetic Algorithm 被引量:1
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作者 LIU Xiu-quan JIANG Yong +3 位作者 LIU Fu-lai LIU Zhao-wei CHANG Yuan-jiang CHEN Guo-ming 《China Ocean Engineering》 SCIE EI CSCD 2021年第1期153-158,共6页
Vortex induced vibration(VIV)is a challenge in ocean engineering.Several devices including fairings have been designed to suppress VIV.However,how to optimize the design of suppression devices is still a problem to be... Vortex induced vibration(VIV)is a challenge in ocean engineering.Several devices including fairings have been designed to suppress VIV.However,how to optimize the design of suppression devices is still a problem to be solved.In this paper,an optimization design methodology is presented based on data-driven models and genetic algorithm(GA).Data-driven models are introduced to substitute complex physics-based equations.GA is used to rapidly search for the optimal suppression device from all possible solutions.Taking fairings as example,VIV response database for different fairings is established based on parameterized models in which model sections of fairings are controlled by several control points and Bezier curves.Then a data-driven model,which can predict the VIV response of fairings with different sections accurately and efficiently,is trained through BP neural network.Finally,a comprehensive optimization method and process is proposed based on GA and the data-driven model.The proposed method is demonstrated by its application to a case.It turns out that the proposed method can perform the optimization design of fairings effectively.VIV can be reduced obviously through the optimization design. 展开更多
关键词 optimization design vortex induced vibration suppression devices data-driven models BP neural network genetic algorithm
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Optimal Antibody Puri cation Strategies Using Data-Driven Models
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作者 Songsong Liu Lazaros GPapageorgiou 《Engineering》 SCIE EI 2019年第6期1077-1092,共16页
This work addresses the multiscale optimization of the puri cation processes of antibody fragments. Chromatography decisions in the manufacturing processes are optimized, including the number of chromatography columns... This work addresses the multiscale optimization of the puri cation processes of antibody fragments. Chromatography decisions in the manufacturing processes are optimized, including the number of chromatography columns and their sizes, the number of cycles per batch, and the operational ow velocities. Data-driven models of chromatography throughput are developed considering loaded mass, ow velocity, and column bed height as the inputs, using manufacturing-scale simulated datasets based on microscale experimental data. The piecewise linear regression modeling method is adapted due to its simplicity and better prediction accuracy in comparison with other methods. Two alternative mixed-integer nonlinear programming (MINLP) models are proposed to minimize the total cost of goods per gram of the antibody puri cation process, incorporating the data-driven models. These MINLP models are then reformulated as mixed-integer linear programming (MILP) models using linearization techniques and multiparametric disaggregation. Two industrially relevant cases with different chromatography column size alternatives are investigated to demonstrate the applicability of the proposed models. 展开更多
关键词 Antibody purification Multiscale optimization Antigen-binding fragment Mixed-integer programming data-driven model Piecewise linear regression
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Towards data-driven models for diverging emerging technologies for maternal,neonatal and child health services in Sub-Saharan Africa:a systematic review 被引量:2
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作者 John Batani Manoj Sewak Maharaj 《Global Health Journal》 2022年第4期183-191,共9页
Sub-Saharan Africa(SSA)has the highest maternal and under-five mortality rates in the world.The advent of the coronavirus disease 2019 exacerbated the region's problems by overwhelming the health systems and affec... Sub-Saharan Africa(SSA)has the highest maternal and under-five mortality rates in the world.The advent of the coronavirus disease 2019 exacerbated the region's problems by overwhelming the health systems and affecting access to healthcare through travel restrictions and rechanelling of resources towards the containment of the pandemic.The region failed to achieve the Millenium Development Goals on maternal and child mortalities,and is poised to fail to achieve the same goals in the Sustainable Development Goals.To improve on the maternal and child health outcomes,many SSA countries introduced digital technologies for educating pregnant and nurs-ing women,making doctors'appointments and sending reminders to mothers and expectant mothers,as well as capturing information about patients and their illnesses.However,the collected epidemiological data are not being utilised to inform patient care and improve on the quality,efficiency and access to maternal,neonatal and child health(MNCH)care.To the researchers'best knowledge,no review paper has been published that focuses on digital health for MNCH care in SSA and proposes data-driven approaches to the same.Therefore,this study sought to:(1)identify digital systems for MNCH in SSA;(2)identify the applicability and weaknesses of the dig-ital MNCH systems in SSA;and(3)propose a data-driven model for diverging emerging technologies into MNCH services in SSA to make better use of data to improve MNCH care coverage,efficiency and quality.The PRISMA methodology was used in this study.The study revealed that there are no data-driven models for monitoring pregnant women and under-five children in Sub-Saharan Africa,with the available digital health technologies mainly based on SMS and websites.Thus,the current digital health systems in SSA do not support real-time,ubiquitous,pervasive and data-driven healthcare.Their main applicability is in non-real-time pregnancy moni-toring,education and information dissemination.Unless new and more effective approaches are implemented,SSA might remain with the highest and unacceptable maternal and under-five mortality rates globally.The study proposes feasible emerging technologies that can be used to provide data-driven healthcare for MNCH in SSA,and the recommendations on how to make the transition successful as well as the lessons learn from other regions. 展开更多
关键词 data-driven healthcare Under-five mortality Maternal mortality Emerging technologies Pervasive healthcare Sub-Saharan Africa
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Air-Side Heat Transfer Performance Prediction for Microchannel Heat Exchangers Using Data-Driven Models with Dimensionless Numbers
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作者 Long Huang Junjia Zou +2 位作者 Baoqing Liu Zhijiang Jin Jinyuan Qian 《Frontiers in Heat and Mass Transfer》 EI 2024年第6期1613-1643,共31页
This study explores the effectiveness of machine learning models in predicting the air-side performance of microchannel heat exchangers.The data were generated by experimentally validated Computational Fluid Dynam-ics... This study explores the effectiveness of machine learning models in predicting the air-side performance of microchannel heat exchangers.The data were generated by experimentally validated Computational Fluid Dynam-ics(CFD)simulations of air-to-water microchannel heat exchangers.A distinctive aspect of this research is the comparative analysis of four diverse machine learning algorithms:Artificial Neural Networks(ANN),Support Vector Machines(SVM),Random Forest(RF),and Gaussian Process Regression(GPR).These models are adeptly applied to predict air-side heat transfer performance with high precision,with ANN and GPR exhibiting notably superior accuracy.Additionally,this research further delves into the influence of both geometric and operational parameters—including louvered angle,fin height,fin spacing,air inlet temperature,velocity,and tube temperature—on model performance.Moreover,it innovatively incorporates dimensionless numbers such as aspect ratio,fin height-to-spacing ratio,Reynolds number,Nusselt number,normalized air inlet temperature,temperature difference,and louvered angle into the input variables.This strategic inclusion significantly refines the predictive capabilities of the models by establishing a robust analytical framework supported by the CFD-generated database.The results show the enhanced prediction accuracy achieved by integrating dimensionless numbers,highlighting the effectiveness of data-driven approaches in precisely forecasting heat exchanger performance.This advancement is pivotal for the geometric optimization of heat exchangers,illustrating the considerable potential of integrating sophisticated modeling techniques with traditional engineering metrics. 展开更多
关键词 Machine learning microchannel heat exchangers heat transfer data-driven modeling computational fluid dynamics
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An integrated method of data-driven and mechanism models for formation evaluation with logs 被引量:1
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作者 Meng-Lu Kang Jun Zhou +4 位作者 Juan Zhang Li-Zhi Xiao Guang-Zhi Liao Rong-Bo Shao Gang Luo 《Petroleum Science》 2025年第3期1110-1124,共15页
We propose an integrated method of data-driven and mechanism models for well logging formation evaluation,explicitly focusing on predicting reservoir parameters,such as porosity and water saturation.Accurately interpr... We propose an integrated method of data-driven and mechanism models for well logging formation evaluation,explicitly focusing on predicting reservoir parameters,such as porosity and water saturation.Accurately interpreting these parameters is crucial for effectively exploring and developing oil and gas.However,with the increasing complexity of geological conditions in this industry,there is a growing demand for improved accuracy in reservoir parameter prediction,leading to higher costs associated with manual interpretation.The conventional logging interpretation methods rely on empirical relationships between logging data and reservoir parameters,which suffer from low interpretation efficiency,intense subjectivity,and suitability for ideal conditions.The application of artificial intelligence in the interpretation of logging data provides a new solution to the problems existing in traditional methods.It is expected to improve the accuracy and efficiency of the interpretation.If large and high-quality datasets exist,data-driven models can reveal relationships of arbitrary complexity.Nevertheless,constructing sufficiently large logging datasets with reliable labels remains challenging,making it difficult to apply data-driven models effectively in logging data interpretation.Furthermore,data-driven models often act as“black boxes”without explaining their predictions or ensuring compliance with primary physical constraints.This paper proposes a machine learning method with strong physical constraints by integrating mechanism and data-driven models.Prior knowledge of logging data interpretation is embedded into machine learning regarding network structure,loss function,and optimization algorithm.We employ the Physically Informed Auto-Encoder(PIAE)to predict porosity and water saturation,which can be trained without labeled reservoir parameters using self-supervised learning techniques.This approach effectively achieves automated interpretation and facilitates generalization across diverse datasets. 展开更多
关键词 Well log Reservoir evaluation Label scarcity Mechanism model data-driven model Physically informed model Self-supervised learning Machine learning
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Data-driven iterative calibration method for prior knowledge of earth-rockfilldam wetting model parameters
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作者 Shaolin Ding Jiajun Pan +4 位作者 Yanli Wang Lin Wang Han Xu Yiwei Lu Xudong Zhao 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第2期1621-1632,共12页
Wetting deformation in earth-rockfill dams is a critical factor influencingdam safety.Although numerous mathematical models have been developed to describe this phenomenon,most of them rely on empirical formulations a... Wetting deformation in earth-rockfill dams is a critical factor influencingdam safety.Although numerous mathematical models have been developed to describe this phenomenon,most of them rely on empirical formulations and lack prior knowledge of model parameters,which is essential for Bayesian parameter inversion to enhance accuracy and reduce uncertainty.This study introduces a datadriven approach to establishing prior knowledge of earth-rockfill dams.Driving factors are utilized to determine the potential range of model parameters,and settlement changes within this range are calculated.The results are iteratively compared with actual monitoring data until the calculated range encompasses the observed data,thereby providing prior knowledge of the model parameters.The proposed method is applied to the right-bank earth-rockfilldam of Danjiangkou.Employing a Gibbs sample size of 30,000,the proposed method effectively calibrates the prior knowledge of the wetting model parameters,achieving a root mean square error(RMSE)of 5.18 mm for the settlement predictions.By comparison,the use of non-informative priors with sample sizes of 30,000 and 50,000 results in significantly larger RMSE values of 11.97 mm and 16.07 mm,respectively.Furthermore,the computational efficiencyof the proposed method is demonstrated by an inversion computation time of 902 s for 30,000 samples,which is notably shorter than the 1026 s and 1558 s required for noninformative priors with 30,000 and 50,000 samples,respectively.These findingsunderscore the superior performance of the proposed approach in terms of both prediction accuracy and computational efficiency.These results demonstrate that the proposed method not only improves the predictive accuracy but also enhances the computational efficiency,enabling optimal parameter identificationwith reduced computational effort.This approach provides a robust and efficientframework for advancing dam safety assessments. 展开更多
关键词 Earth-rockfilldam Wetting deformation Prior knowledge data-driven Bayesian inversion
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A comprehensive review of remaining useful life prediction methods for lithium-ion batteries:Models,trends,and engineering applications
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作者 Yang Li Haotian Shi +5 位作者 Shunli Wang Qi Huang Chunmei Liu Shiliang Nie Xianyi Jia Tao Luo 《Journal of Energy Chemistry》 2026年第1期384-414,I0009,共32页
Under complex working conditions,accurate prediction of the remaining useful life(RUL)of lithium-ion batteries is of great significance to ensure the stable operation of energy storage systems,the safe driving of elec... Under complex working conditions,accurate prediction of the remaining useful life(RUL)of lithium-ion batteries is of great significance to ensure the stable operation of energy storage systems,the safe driving of electric vehicles,and the continuous power supply of electronic devices.This paper systematically describes the RUL prediction methods of lithium-ion batteries and comprehensively summarizes the development status and future trends in this field.First,the battery degradation mechanisms and lightweight data acquisition are analyzed.Secondly,a systematic classification model is constructed for the more widely used lithium battery RUL prediction methods,and the application characteristics and implementation limitations of different methods are analyzed in detail.An innovative classification framework for hybrid methods is proposed based on the depth of physical-data interaction.Then,collaborative modelling of calendar ageing and cyclic ageing is discussed,revealing their coupled effects and corresponding RUL prediction methods.Finally,the technical bottlenecks faced by the current RUL prediction of lithium batteries are identified,potential solutions are proposed,and the future development trends are outlined. 展开更多
关键词 Lithium-ion batteries Remaining useful life model-driven approach data-driven approach Hybrid approach
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Ecosystem service models are indeed being validated:A response to Pereira et al.(2025)
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作者 James M.Bullock Danny A.P.Hooftman +1 位作者 John W.Redhead Simon Willcock 《Geography and Sustainability》 2026年第1期247-248,共2页
In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation ... In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation is provided”and that“the validation step is largely overlooked”.This assertion may have been true several years ago,for example,when Ochoa and Urbina-Cardona(2017)made a similar observation.However,there has been much work on ES model validation over the last decade. 展开更多
关键词 evaluation MAPPING modeling es model ecosystem services VALIDATION
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CIT-Rec:Enhancing Sequential Recommendation System with Large Language Models
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作者 Ziyu Li Zhen Chen +2 位作者 Xuejing Fu Tong Mo Weiping Li 《Computers, Materials & Continua》 2026年第3期2328-2343,共16页
Recommendation systems are key to boosting user engagement,satisfaction,and retention,particularly on media platforms where personalized content is vital.Sequential recommendation systems learn from user-item interact... Recommendation systems are key to boosting user engagement,satisfaction,and retention,particularly on media platforms where personalized content is vital.Sequential recommendation systems learn from user-item interactions to predict future items of interest.However,many current methods rely on unique user and item IDs,limiting their ability to represent users and items effectively,especially in zero-shot learning scenarios where training data is scarce.With the rapid development of Large Language Models(LLMs),researchers are exploring their potential to enhance recommendation systems.However,there is a semantic gap between the linguistic semantics of LLMs and the collaborative semantics of recommendation systems,where items are typically indexed by IDs.Moreover,most research focuses on item representations,neglecting personalized user modeling.To address these issues,we propose a sequential recommendation framework using LLMs,called CIT-Rec,a model that integrates Collaborative semantics for user representation and Image and Text information for item representation to enhance Recommendations.Specifically,by aligning intuitive image information with text containing semantic features,we can more accurately represent items,improving item representation quality.We focus not only on item representations but also on user representations.To more precisely capture users’personalized preferences,we use traditional sequential recommendation models to train on users’historical interaction data,effectively capturing behavioral patterns.Finally,by combining LLMs and traditional sequential recommendation models,we allow the LLM to understand linguistic semantics while capturing collaborative semantics.Extensive evaluations on real-world datasets show that our model outperforms baseline methods,effectively combining user interaction history with item visual and textual modalities to provide personalized recommendations. 展开更多
关键词 Large language models vision language models sequential recommendation instruction tuning
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Do Higher Horizontal Resolution Models Perform Better?
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作者 Shoji KUSUNOKI 《Advances in Atmospheric Sciences》 2026年第1期259-262,共4页
Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(... Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)]. 展开更多
关键词 enhancing model resolution refinement data assimilation systems section climate model climate projection higher horizontal resolution seasonal forecasting simulation seasonal migration rain bands model resolution
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Secured-FL:Blockchain-Based Defense against Adversarial Attacks on Federated Learning Models
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作者 Bello Musa Yakubu Nor Shahida Mohd Jamail +1 位作者 Rabia Latif Seemab Latif 《Computers, Materials & Continua》 2026年第3期734-757,共24页
Federated Learning(FL)enables joint training over distributed devices without data exchange but is highly vulnerable to attacks by adversaries in the form of model poisoning and malicious update injection.This work pr... Federated Learning(FL)enables joint training over distributed devices without data exchange but is highly vulnerable to attacks by adversaries in the form of model poisoning and malicious update injection.This work proposes Secured-FL,a blockchain-based defensive framework that combines smart contract-based authentication,clustering-driven outlier elimination,and dynamic threshold adjustment to defend against adversarial attacks.The framework was implemented on a private Ethereum network with a Proof-of-Authority consensus algorithm to ensure tamper-resistant and auditable model updates.Large-scale simulation on the Cyber Data dataset,under up to 50%malicious client settings,demonstrates Secured-FL achieves 6%-12%higher accuracy,9%-15%lower latency,and approximately 14%less computational expense compared to the PPSS benchmark framework.Additional tests,including confusion matrices,ROC and Precision-Recall curves,and ablation tests,confirm the interpretability and robustness of the defense.Tests for scalability also show consistent performance up to 500 clients,affirming appropriateness to reasonably large deployments.These results make Secured-FL a feasible,adversarially resilient FL paradigm with promising potential for application in smart cities,medicine,and other mission-critical IoT deployments. 展开更多
关键词 Federated learning(FL) blockchain FL based privacy model defense FL model security ethereum smart contract
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Review of machine learning tight-binding models:Route to accurate and scalable electronic simulations
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作者 Jijie Zou Zhanghao Zhouyin +1 位作者 Shishir Kumar Pandey Qiangqiang Gu 《Chinese Physics B》 2026年第1期2-12,共11页
The rapid advancement of machine learning based tight-binding Hamiltonian(MLTB)methods has opened new avenues for efficient and accurate electronic structure simulations,particularly in large-scale systems and long-ti... The rapid advancement of machine learning based tight-binding Hamiltonian(MLTB)methods has opened new avenues for efficient and accurate electronic structure simulations,particularly in large-scale systems and long-time scenarios.This review begins with a concise overview of traditional tight-binding(TB)models,including both(semi-)empirical and first-principles approaches,establishing the foundation for understanding MLTB developments.We then present a systematic classification of existing MLTB methodologies,grouped into two major categories:direct prediction of TB Hamiltonian elements and inference of empirical parameters.A comparative analysis with other ML-based electronic structure models is also provided,highlighting the advancement of MLTB approaches.Finally,we explore the emerging MLTB application ecosystem,highlighting how the integration of MLTB models with a diverse suite of post-processing tools from linear-scaling solvers to quantum transport frameworks and molecular dynamics interfaces is essential for tackling complex scientific problems across different domains.The continued advancement of this integrated paradigm promises to accelerate materials discovery and open new frontiers in the predictive simulation of complex quantum phenomena. 展开更多
关键词 machine learning tight-binding model electronic simulations
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Transformation of Verbal Descriptions of Process Flows into Business Process Modelling and Notation Models Using Multimodal Artificial Intelligence:Application in Justice
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作者 Silvia Alayón Carlos Martín +3 位作者 Jesús Torres Manuel Bacallado Rosa Aguilar Guzmán Savirón 《Computer Modeling in Engineering & Sciences》 2026年第2期870-892,共23页
Business Process Modelling(BPM)is essential for analyzing,improving,and automating the flow of information within organizations,but traditional approaches based on manual interpretation are slow,error-prone,and requir... Business Process Modelling(BPM)is essential for analyzing,improving,and automating the flow of information within organizations,but traditional approaches based on manual interpretation are slow,error-prone,and require a high level of expertise.This article proposes an innovative alternative solution that overcomes these limitations by automatically generating comprehensive Business Process Modelling and Notation(BPMN)diagrams solely from verbal descriptions of the processes to be modeled,utilizing Large Language Models(LLMs)and multimodal Artificial Intelligence(AI).Experimental results,based on video recordings of process explanations provided by an expert from an organization(in this case,the Commercial Courts of a public justice administration),demonstrate that the proposed methodology successfully enables the automatic generation of complete and accurate BPMN diagrams,leading to significant improvements in the speed,accuracy,and accessibility of process modeling.This research makes a substantial contribution to the field of business process modeling,as its methodology is groundbreaking in its use of LLMs and multimodal AI capabilities to handle different types of source material(text and video),combining several tools to minimize the number of queries and reduce the complexity of the prompts required for the automatic generation of successful BPMN diagrams. 展开更多
关键词 Process modelling verbal description BPMN LLM multimodal AI
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Recent advances in animal models for pathological scar research:A comprehensive review of experimental approaches and translational relevance
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作者 Diana-Larisa Ancuța Mariana Văduva +1 位作者 Cristin Coman Iuliana Caraș 《Animal Models and Experimental Medicine》 2026年第1期59-71,共13页
Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecul... Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies. 展开更多
关键词 animal model EXPERIMENT hypertrophic scar keloid scar TRANSLATION
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When Large Language Models and Machine Learning Meet Multi-Criteria Decision Making: Fully Integrated Approach for Social Media Moderation
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作者 Noreen Fuentes Janeth Ugang +4 位作者 Narcisan Galamiton Suzette Bacus Samantha Shane Evangelista Fatima Maturan Lanndon Ocampo 《Computers, Materials & Continua》 2026年第1期2137-2162,共26页
This study demonstrates a novel integration of large language models,machine learning,and multicriteria decision-making to investigate self-moderation in small online communities,a topic under-explored compared to use... This study demonstrates a novel integration of large language models,machine learning,and multicriteria decision-making to investigate self-moderation in small online communities,a topic under-explored compared to user behavior and platform-driven moderation on social media.The proposed methodological framework(1)utilizes large language models for social media post analysis and categorization,(2)employs k-means clustering for content characterization,and(3)incorporates the TODIM(Tomada de Decisão Interativa Multicritério)method to determine moderation strategies based on expert judgments.In general,the fully integrated framework leverages the strengths of these intelligent systems in a more systematic evaluation of large-scale decision problems.When applied in social media moderation,this approach promotes nuanced and context-sensitive self-moderation by taking into account factors such as cultural background and geographic location.The application of this framework is demonstrated within Facebook groups.Eight distinct content clusters encompassing safety,harassment,diversity,and misinformation are identified.Analysis revealed a preference for content removal across all clusters,suggesting a cautious approach towards potentially harmful content.However,the framework also highlights the use of other moderation actions,like account suspension,depending on the content category.These findings contribute to the growing body of research on self-moderation and offer valuable insights for creating safer and more inclusive online spaces within smaller communities. 展开更多
关键词 Self-moderation user-generated content k-means clustering TODIM large language models
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Therapeutic Potential of Fingolimod and Dimethyl Fumarate in Preclinical Pancreatic Cancer Models
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作者 Pauline Gousseau Laurie Genest +1 位作者 Guillaume Froget Tristan Rupp 《Oncology Research》 2026年第3期387-405,共19页
Objectives:The five-year survival rate for pancreatic cancer is notably low,posing a significant challenge to patient health.The primary treatments are radiotherapy and chemotherapy,sometimes combined with targeted th... Objectives:The five-year survival rate for pancreatic cancer is notably low,posing a significant challenge to patient health.The primary treatments are radiotherapy and chemotherapy,sometimes combined with targeted therapy;however,their clinical benefits are limited.Therefore,developing new models to evaluate the therapeutic potential of novel molecules is essential.Fingolimod and Dimethyl Fumarate(DMF),currently used to treat multiple sclerosis,have recently been shown to have anti-cancer effects in several preclinical tumor models.This study aims to evaluate the therapeutic potential of Fingolimod and DMF in pancreatic cancer by investigating their respective in vitro cytotoxicity and in vivo antitumor effects.Methods:In this study,we evaluated for the first time these two drugs in pancreatic preclinical models in vitro using 3D spheroid tumor models and in vivo,which are compared to two standard-of-care consisting of Gemcitabine and Erlotinib.Results:In vitro,both Fingolimod and DMF induced cytotoxicity in spheroids from two pancreatic cell lines.Additionally,Fingolimod and DMF displayed anticancer effects in two subcutaneous xenograft models using PANC-1 and CFPAC-1 cells.Conclusions:Although the responses observed with Fingolimod and DMF were similar to those of Gemcitabine and Erlotinib,these findings indicate a potential emerging interest in Fingolimod and DMF for the treatment of pancreatic cancer.However,further work is still necessary to fully characterize how these drugs affect tumor progression. 展开更多
关键词 Pancreatic cancer preclinical models tumor progression FINGOLIMOD dimethyl Fumarate
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Animal models of benign airway stenosis:Advances in construction techniques,evaluation systems,and perspectives
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作者 Wusheng Zhang Yilin Chen +4 位作者 Chengcheng Yang Yuchao Dong Haidong Huang Hui Shi Chong Bai 《Animal Models and Experimental Medicine》 2026年第2期280-297,共18页
The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention a... The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention and treatment methods.Animal models serve as essential tools for investigating disease mechanisms and assessing novel therapeutic strategies,and the scientific rigor of their construction and validation significantly impacts the reliability of research findings.This paper systematically reviews the research progress and evaluation systems of BAS animal models over the past decade,aiming to provide a robust foundation for the optimized construction of BAS models,intervention studies,and clinical translation.This effort is intended to facilitate the innovation and advancement in BAS prevention and treatment strategies. 展开更多
关键词 airway stenosis animal models benign airway stenosis evaluation systems
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Command-agent:Reconstructing warfare simulation and command decision-making using large language models
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作者 Mengwei Zhang Minchi Kuang +3 位作者 Heng Shi Jihong Zhu Jingyu Zhu Xiao Jiang 《Defence Technology(防务技术)》 2026年第2期294-313,共20页
War rehearsals have become increasingly important in national security due to the growing complexity of international affairs.However,traditional rehearsal methods,such as military chess simulations,are inefficient an... War rehearsals have become increasingly important in national security due to the growing complexity of international affairs.However,traditional rehearsal methods,such as military chess simulations,are inefficient and inflexible,with particularly pronounced limitations in command and decision-making.The overwhelming volume of information and high decision complexity hinder the realization of autonomous and agile command and control.To address this challenge,an intelligent warfare simulation framework named Command-Agent is proposed,which deeply integrates large language models(LLMs)with digital twin battlefields.By constructing a highly realistic battlefield environment through real-time simulation and multi-source data fusion,the natural language interaction capabilities of LLMs are leveraged to lower the command threshold and to enable autonomous command through the Observe-Orient-Decide-Act(OODA)feedback loop.Within the Command-Agent framework,a multimodel collaborative architecture is further adopted to decouple the decision-generation and command-execution functions of LLMs.By combining specialized models such as Deep Seek-R1 and MCTool,the limitations of single-model capabilities are overcome.MCTool is a lightweight execution model fine-tuned for military Function Calling tasks.The framework also introduces a Vector Knowledge Base to mitigate hallucinations commonly exhibited by LLMs.Experimental results demonstrate that Command-Agent not only enables natural language-driven simulation and control but also deeply understands commander intent.Leveraging the multi-model collaborative architecture,during red-blue UAV confrontations involving 2 to 8 UAVs,the integrated score is improved by an average of 41.8%compared to the single-agent system(MCTool),accompanied by a 161.8%optimization in the battle loss ratio.Furthermore,when compared with multi-agent systems lacking the knowledge base,the inclusion of the Vector Knowledge Base further improves overall performance by 16.8%.In comparison with the general model(Qwen2.5-7B),the fine-tuned MCTool leads by 5%in execution efficiency.Therefore,the proposed Command-Agent introduces a novel perspective to the military command system and offers a feasible solution for intelligent battlefield decision-making. 展开更多
关键词 Digital twin battlefield Large language models Multi-agent system Military command
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