Daphnane-type diterpenenoids are the major biologically active constituents in the genus Daphne.We find that there are about 101 Daphnane-type diterpenes in this genus,most of those compounds show different degrees of...Daphnane-type diterpenenoids are the major biologically active constituents in the genus Daphne.We find that there are about 101 Daphnane-type diterpenes in this genus,most of those compounds show different degrees of inhibitory effect on various cancer cell.Some of them have been studied in depth and the potent molecular mechanisms might be associated with modulation of different cell-signaling pathways.In addition,some compounds of this type also can inhibit the synthesis of protein and DNA.Absolutely,the anti-tumor activity of Daphnane-type diterpenes is worthy of attention.Unfortunately,most of the current research on the activity of these compounds is focused on simple drug efficacy,and its in-depth mechanism research is far from enough.On the other point of view,there still exists wide growing space on the depth of these compounds.展开更多
Genkwa flos is a well-known traditional Chinese medicine, which exhibits abundant biological activities such as antiinflammatory, analgesic, immunoregulatory activities and anti-rheumatic arthritis activity. Recent ph...Genkwa flos is a well-known traditional Chinese medicine, which exhibits abundant biological activities such as antiinflammatory, analgesic, immunoregulatory activities and anti-rheumatic arthritis activity. Recent pharmacological studies showed that Genkwa flos might also have the antitumor effect. Daphnane-type diterpenoids (DDs) are one of the main anti-tumor constitutions in Genkwa flos. However, the underlying anticancer molecular mechanisms of this type of compounds are still unclear. This review aims to give a systematic summary of DDs from Genkwa flos to better understand the anti-tumor activitiy by focusing on cell arrest, apoptosis, topoisomerase inhibition, melanin inhibition and the reverse of multi-drug-resistance (MDR). In addition, we are also going to make an overview of the mechanisms identified up to now. The significant findings may provide that DDs in Genkwa flos is a promising targeted-cancer agent.展开更多
基金financially supported by National Nature Science Foundation of China[Grant No.81573319, 81872766, 81973528]China Postdoctoral Science Foundation[Grant No.2019M661135, 2017M620104]。
文摘Daphnane-type diterpenenoids are the major biologically active constituents in the genus Daphne.We find that there are about 101 Daphnane-type diterpenes in this genus,most of those compounds show different degrees of inhibitory effect on various cancer cell.Some of them have been studied in depth and the potent molecular mechanisms might be associated with modulation of different cell-signaling pathways.In addition,some compounds of this type also can inhibit the synthesis of protein and DNA.Absolutely,the anti-tumor activity of Daphnane-type diterpenes is worthy of attention.Unfortunately,most of the current research on the activity of these compounds is focused on simple drug efficacy,and its in-depth mechanism research is far from enough.On the other point of view,there still exists wide growing space on the depth of these compounds.
文摘Genkwa flos is a well-known traditional Chinese medicine, which exhibits abundant biological activities such as antiinflammatory, analgesic, immunoregulatory activities and anti-rheumatic arthritis activity. Recent pharmacological studies showed that Genkwa flos might also have the antitumor effect. Daphnane-type diterpenoids (DDs) are one of the main anti-tumor constitutions in Genkwa flos. However, the underlying anticancer molecular mechanisms of this type of compounds are still unclear. This review aims to give a systematic summary of DDs from Genkwa flos to better understand the anti-tumor activitiy by focusing on cell arrest, apoptosis, topoisomerase inhibition, melanin inhibition and the reverse of multi-drug-resistance (MDR). In addition, we are also going to make an overview of the mechanisms identified up to now. The significant findings may provide that DDs in Genkwa flos is a promising targeted-cancer agent.
