The broadband fluorescence guided-waves excited in DANS/PMMA polymer thin film waveguides by an Ar+laser beam were demonstrated in terms of the observation of mlines with colour array.Considering the high brightness o...The broadband fluorescence guided-waves excited in DANS/PMMA polymer thin film waveguides by an Ar+laser beam were demonstrated in terms of the observation of mlines with colour array.Considering the high brightness of these m-lines observation,we assert that it is a kind of stimulated amplification of fluorescence guided-wave.展开更多
Nous savons encore peu de choses sur la place qu＇ont les femmes dansla francaise, sur leur participation aux qui ont I＇ de la France dans la . Certes quelques noms de femmes qui ont un pendant la flottent dans...Nous savons encore peu de choses sur la place qu＇ont les femmes dansla francaise, sur leur participation aux qui ont I＇ de la France dans la . Certes quelques noms de femmes qui ont un pendant la flottent dans la commune: Marie-An-toinette, Manon Rolland, Charlotte Corday etc…En les prenant pour展开更多
Se trouvant dans le sud-est de la Chine au bord dela mer, la province du Fujian s’appelle aussi toutsimplement "Min". Les anc(?)tres d’une grande partie de lapopulation de Taiwan sont venus du Fujian (Min)...Se trouvant dans le sud-est de la Chine au bord dela mer, la province du Fujian s’appelle aussi toutsimplement "Min". Les anc(?)tres d’une grande partie de lapopulation de Taiwan sont venus du Fujian (Min). Les展开更多
目的:探讨脑电地形图在脑瘤疗效判断上的应用价值。方法:通过对30例脑瘤治疗 前后脑电地形图改变进行对比研究。结果:脑电地形图在治疗前后有明显改变。结论:脑电地形图 可以作为脑瘤疗效评价的一个有价值的指标。<正>Objectif: D...目的:探讨脑电地形图在脑瘤疗效判断上的应用价值。方法:通过对30例脑瘤治疗 前后脑电地形图改变进行对比研究。结果:脑电地形图在治疗前后有明显改变。结论:脑电地形图 可以作为脑瘤疗效评价的一个有价值的指标。<正>Objectif: De explorer valeure appliq6e de encephale adas dan evaluation de effet cur atif de tumeur cerebral. Methode: Etude comparative de encephale adas de 30 malades avec tumeur cerebral avant et apr6s traitement est realise. Resultat: Encephale adas est change manifestement avant et apres traitement. Conclusion: Encephale adas est un index valable de jugement de effet curatif dans tumeur cerebral.展开更多
Hiver,2000. Quand j'étais encore écolière,j'ai appris un texte d'Alphonse Daudet :La dernière classe. Ma première impression sur le franais :C'est la plus belle langue du mo...Hiver,2000. Quand j'étais encore écolière,j'ai appris un texte d'Alphonse Daudet :La dernière classe. Ma première impression sur le franais :C'est la plus belle langue du monde. Au fur et à mesure,j'ai fait la connaissance des Champs-Elysées,du Louvre,et puis,de la Tour Eiffel. Je suis convaincue avec admiration de leur charme.展开更多
From the perspective of historical geography,this study conducts an in-depth investigation into the heritage timeline,regional characteristics,and formative factors of Longsha medical school(龙砂医派Longsha medicine)....From the perspective of historical geography,this study conducts an in-depth investigation into the heritage timeline,regional characteristics,and formative factors of Longsha medical school(龙砂医派Longsha medicine).Tracing its origin to the Song Dynasty,Longsha medicine has been handed down through successive generations,with numerous renowned physicians such as Xu Shuwei(许叔微)and Lu Wengui(陆文圭)making remarkable contributions to its development.A combination of favorable geographical location,superior ecological environment,an open cultural atmosphere,abundant local medicinal resources,and the unique physical constitutions of the local population comprehensively shaped the school’s distinct features and fueled its evolution.The core characteristics of Longsha medicine can be summarized as:emphasizing on inheritance and academic exploration,focusing on traditional Chinese medicine(TCM)classical theories and clinical practice,and embodying profound cultural connotations.As a regional and comprehensive TCM academic school,it originated in the Huashi area(historically known as Longsha)in Jiangyin County,Wuxi City,Jiangsu Province,gradually expanded to the areas surrounding Taihu Lake(太湖),and exerted far-reaching influence nationwide.Serving as a core representative of the TCM academic field in the Yangtze River Delta,Longsha medicine boasts a long history,solid cultural foundation,a galaxy of eminent physicians,classic works,distinct academic traits,unique diagnostic and therapeutic techniques,and vigorous dynamic inheritance.Contemporary in-depth research on Longsha medicine not only facilitates the dynamic inheritance of the core TCM theories such as Wu Yun Liu Qi(五运六气the five movements and six qi theory)in Huang Di Nei Jing(《黄帝内经》The Yellow Emperor’s Inner Classic)but also verifies the effectiveness and scientific validity of TCM classical theories in guiding the prevention and treatment of modern diseases.Thus,the study helps to protect regional medical-historical sources,enrich the doctrinal landscape of TCM,sustain distinctive academic techniques,catalyzes contemporary innovation,cultivates characteristic TCM talent,and enhances clinical service effectiveness.展开更多
This article takes all the China-related reports in Vietnam’s Nhan Dan from 2016 to 2020 as the research object,and discusses the national image of China constructed by Vietnam’s mainstream media from the aspects of...This article takes all the China-related reports in Vietnam’s Nhan Dan from 2016 to 2020 as the research object,and discusses the national image of China constructed by Vietnam’s mainstream media from the aspects of the number of reports and the content of reports around the news theme.The study found that Nhan Dan gave China all-round attention,and reported extensively on key issues and social life related to China’s politics,economy,and military affairs.The positive and negative images of China’s national image presented in the reports coexist.The reports reflect the attitude of Nhan Dan as a mainstream media in Vietnam.The reports not only emphasize China’s important position in international affairs,but also hold an attitude of risk awareness and threat vigilance.展开更多
Objective To explore the medication patterns of Professor Zulong Wang in treating sleep-related painful erection(SRPE)through data mining,aiming to discover new therapeutic strategies for traditional Chinese medicine ...Objective To explore the medication patterns of Professor Zulong Wang in treating sleep-related painful erection(SRPE)through data mining,aiming to discover new therapeutic strategies for traditional Chinese medicine in managing this condition.Methods Medical records of SRPE patients treated by Professor Zulong Wang at the First Affiliated Hospital of Henan University of Chinese Medicine from February 2021 to December 2024 were collected to establish a database.Frequency analysis,association rule analysis,and cluster analysis were employed to examine the frequency of herb use,four properties and five flavors,channel tropisms,and herb combinations.Results A total of 59 prescriptions meeting the criteria were included,involving 81 Chinese herbs,among which 27 herbs were used 10 or more times.The primary herb properties were cold,warm,and neutral,with bitter,sweet,and pungent flavors being most common.The herbs predominantly entered the liver,heart,spleen,and kidney channels.Forty-three commonly used herb combinations were identified,and cluster analysis revealed six core herb groups.Conclusion Professor Zulong Wang primarily treats SRPE with modified Huoluo Xiaoling Dan,focusing on unblocking collaterals and relieving pain,supplemented by soothing the liver and regulating qi,resolving stasis and phlegm,nourishing yin and reducing fire,and tonifying the kidney and activating blood circulation.展开更多
OBJECTIVE:To investigate the mechanism of Dan Ze mixture(丹泽合剂,DZM)in the treatment of lipotoxic cardiomyopathy.METHODS:Ultra-performance liquid chromatography tandem mass spectrometry was employed to characterize ...OBJECTIVE:To investigate the mechanism of Dan Ze mixture(丹泽合剂,DZM)in the treatment of lipotoxic cardiomyopathy.METHODS:Ultra-performance liquid chromatography tandem mass spectrometry was employed to characterize the serum migration constituents of DZM.A lipotoxic cardiomyopathy rat model was established through high-fat diet and intervened by different doses of DZM.The cardiac function was assessed using echocardiography,and hematoxylin and eosin,oil red O,and Masson staining were conducted to evaluate morphological changes,lipid accumulation,and fibrosis in myocardial tissue.Serum myocardial enzyme activity,lipid levels,and lipid content of myocardial tissue were measured,while fluorescent staining and colorimetry were used to assess oxidation levels in myocardial tissue.Mitochondrial membrane potential was detected by 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethyl-imidacarbocyanineiodide(JC-1).Transmission electron microscopy was employed to observe ultrastructure and mitochondrial structure changes in myocardial tissue.Fluorescence double staining and colocalization were utilized to observe the binding of autophagosomes and mitochondria,while immunohistochemical staining was used to detect the expression of mitophagy-related proteins.Terminal deoxynucleoitidyl transferase mediated nick end labeling staining was employed for the identification of apoptosis in myocardial tissue,while quantitative real-time reverse transcriptase polymerase chain reaction(q RT-PCR)and Western blot were utilized for the detection of apoptosis,B-cell lymphoma-2 adenovirus E1B 19 k Da-interacting protein 3(BNIP3)/mitophagy signaling pathway-related genes and proteins.In palmitic acid-induced Rat H9C2 cardiomyocytes(H9c2)cells,various cellular parameters including cell viability,lactate dehydrogenase release,apoptosis rate,oxidative stress level,mitochondrial structure and function,and mitophagy level were assessed after the treatment of DZM drug-containing serum for a duration of 24 h.The cellular expressions of BNIP3/mitophagy signaling pathway relevant genes and proteins were further evaluated using q RT-PCR and Western blot techniques.RESULTS:A total of 295 prototypes(e.g.,phenolic acids,quinones,terpenoids)were identified in serum of rats after oral administration of DZM.In vivo,DZM therapy has been shown to effectively enhance cardiac function,mitigate high-fat diet-induced myocardial structural damage and lipid accumulation.Furthermore,DZM has demonstrated the ability to reduce lipid levels,attenuate cell apoptosis,combat oxidative stress,enhance mitochondrial structure and function,and activate the BNIP3/mitophagy signaling pathway.Furthermore,the silencing of BNIP3 has been shown to exacerbate palmitic acid-induced damages in H9c2 cells,while inhibiting the BNIP3/mitophagy signaling pathway can mitigate the inhibitory effects of DZM on palmitic acidinduced apoptosis,lipid deposition and oxidative stress.CONCLUSION:This study presents preliminary evidence for the therapeutic efficacy of DZM on lipotoxic cardiomyopathy through the activating BNIP3/mitophagy signaling pathway.展开更多
基金the National Natural Science Foundation of China,and by the National 863 High-Tech.Bond of China.
文摘The broadband fluorescence guided-waves excited in DANS/PMMA polymer thin film waveguides by an Ar+laser beam were demonstrated in terms of the observation of mlines with colour array.Considering the high brightness of these m-lines observation,we assert that it is a kind of stimulated amplification of fluorescence guided-wave.
文摘Nous savons encore peu de choses sur la place qu＇ont les femmes dansla francaise, sur leur participation aux qui ont I＇ de la France dans la . Certes quelques noms de femmes qui ont un pendant la flottent dans la commune: Marie-An-toinette, Manon Rolland, Charlotte Corday etc…En les prenant pour
文摘Se trouvant dans le sud-est de la Chine au bord dela mer, la province du Fujian s’appelle aussi toutsimplement "Min". Les anc(?)tres d’une grande partie de lapopulation de Taiwan sont venus du Fujian (Min). Les
文摘目的:探讨脑电地形图在脑瘤疗效判断上的应用价值。方法:通过对30例脑瘤治疗 前后脑电地形图改变进行对比研究。结果:脑电地形图在治疗前后有明显改变。结论:脑电地形图 可以作为脑瘤疗效评价的一个有价值的指标。<正>Objectif: De explorer valeure appliq6e de encephale adas dan evaluation de effet cur atif de tumeur cerebral. Methode: Etude comparative de encephale adas de 30 malades avec tumeur cerebral avant et apr6s traitement est realise. Resultat: Encephale adas est change manifestement avant et apres traitement. Conclusion: Encephale adas est un index valable de jugement de effet curatif dans tumeur cerebral.
文摘Hiver,2000. Quand j'étais encore écolière,j'ai appris un texte d'Alphonse Daudet :La dernière classe. Ma première impression sur le franais :C'est la plus belle langue du monde. Au fur et à mesure,j'ai fait la connaissance des Champs-Elysées,du Louvre,et puis,de la Tour Eiffel. Je suis convaincue avec admiration de leur charme.
基金the grants from the second round of Construction Project of National Traditional Chinese Medicine Academic Schools Inheritance Studio of the State Administration of Traditional Chinese Medicine(No.62,2019)the Seventh Batch of National Projects for Inheriting Academic Experience of Veteran Traditional Chinese Medicine Experts(No.[2022]76)Construction Project of Lu Shu’s National Veteran Traditional Chinese Medicine Expert Inheritance Studio under the National Administration of Traditional Chinese Medicine(No.[2022]75).
文摘From the perspective of historical geography,this study conducts an in-depth investigation into the heritage timeline,regional characteristics,and formative factors of Longsha medical school(龙砂医派Longsha medicine).Tracing its origin to the Song Dynasty,Longsha medicine has been handed down through successive generations,with numerous renowned physicians such as Xu Shuwei(许叔微)and Lu Wengui(陆文圭)making remarkable contributions to its development.A combination of favorable geographical location,superior ecological environment,an open cultural atmosphere,abundant local medicinal resources,and the unique physical constitutions of the local population comprehensively shaped the school’s distinct features and fueled its evolution.The core characteristics of Longsha medicine can be summarized as:emphasizing on inheritance and academic exploration,focusing on traditional Chinese medicine(TCM)classical theories and clinical practice,and embodying profound cultural connotations.As a regional and comprehensive TCM academic school,it originated in the Huashi area(historically known as Longsha)in Jiangyin County,Wuxi City,Jiangsu Province,gradually expanded to the areas surrounding Taihu Lake(太湖),and exerted far-reaching influence nationwide.Serving as a core representative of the TCM academic field in the Yangtze River Delta,Longsha medicine boasts a long history,solid cultural foundation,a galaxy of eminent physicians,classic works,distinct academic traits,unique diagnostic and therapeutic techniques,and vigorous dynamic inheritance.Contemporary in-depth research on Longsha medicine not only facilitates the dynamic inheritance of the core TCM theories such as Wu Yun Liu Qi(五运六气the five movements and six qi theory)in Huang Di Nei Jing(《黄帝内经》The Yellow Emperor’s Inner Classic)but also verifies the effectiveness and scientific validity of TCM classical theories in guiding the prevention and treatment of modern diseases.Thus,the study helps to protect regional medical-historical sources,enrich the doctrinal landscape of TCM,sustain distinctive academic techniques,catalyzes contemporary innovation,cultivates characteristic TCM talent,and enhances clinical service effectiveness.
文摘This article takes all the China-related reports in Vietnam’s Nhan Dan from 2016 to 2020 as the research object,and discusses the national image of China constructed by Vietnam’s mainstream media from the aspects of the number of reports and the content of reports around the news theme.The study found that Nhan Dan gave China all-round attention,and reported extensively on key issues and social life related to China’s politics,economy,and military affairs.The positive and negative images of China’s national image presented in the reports coexist.The reports reflect the attitude of Nhan Dan as a mainstream media in Vietnam.The reports not only emphasize China’s important position in international affairs,but also hold an attitude of risk awareness and threat vigilance.
基金supported by the National Natural Science Foundation of China General Program(82174377)National Traditional Chinese Medicine Advantageous Specialty Construction Project(GZY-ZY[2024]90).
文摘Objective To explore the medication patterns of Professor Zulong Wang in treating sleep-related painful erection(SRPE)through data mining,aiming to discover new therapeutic strategies for traditional Chinese medicine in managing this condition.Methods Medical records of SRPE patients treated by Professor Zulong Wang at the First Affiliated Hospital of Henan University of Chinese Medicine from February 2021 to December 2024 were collected to establish a database.Frequency analysis,association rule analysis,and cluster analysis were employed to examine the frequency of herb use,four properties and five flavors,channel tropisms,and herb combinations.Results A total of 59 prescriptions meeting the criteria were included,involving 81 Chinese herbs,among which 27 herbs were used 10 or more times.The primary herb properties were cold,warm,and neutral,with bitter,sweet,and pungent flavors being most common.The herbs predominantly entered the liver,heart,spleen,and kidney channels.Forty-three commonly used herb combinations were identified,and cluster analysis revealed six core herb groups.Conclusion Professor Zulong Wang primarily treats SRPE with modified Huoluo Xiaoling Dan,focusing on unblocking collaterals and relieving pain,supplemented by soothing the liver and regulating qi,resolving stasis and phlegm,nourishing yin and reducing fire,and tonifying the kidney and activating blood circulation.
基金Scientific Research Project of Hebei Province Administration of Traditional Chinese Medicine:to Explore the Protective Effect and Mechanism of Zexie Decoction on Lipotoxic Cardiomyopathy based on the p-mitogen-activated protein kinases/Peroxisome proliferator-activated receptorγcoactivator 1-alpha(p MAPK/PGC-1α)Signaling Pathway(No.2022096)Medical Science Research Project of Hebei Province:the Effect of 23-acetyl Alismol-B on Mitochondrial Function in Palmitic Acid-induced H9c2 Cells Was Investigated based on the Ca2+-Cyclic Adenosine Monophosphate(c AMP)-Response Element Binding Protein/c AMP Response Element(CREB/CRE)-PGC-1αSignaling Pathway(No.20221490)+1 种基金Hebei province natural science fund project:Study on the Mechanism of Danshen Zexie Decoction in Activating Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Trigger 0mi/Htr A2,Restoring Autophagic Flux and Enhancing Metabolism-Related Fatty Liver Disease(No.H2023423064)Hebei graduate student innovation ability funding training project:to Investigate the Protective Effects and Underlying Mechanisms of Zexie Decoction on Lipotoxic Cardiomyopathy,with A Focus on the PGC-1a Signaling Pathway(No.CXZZBS2022096)。
文摘OBJECTIVE:To investigate the mechanism of Dan Ze mixture(丹泽合剂,DZM)in the treatment of lipotoxic cardiomyopathy.METHODS:Ultra-performance liquid chromatography tandem mass spectrometry was employed to characterize the serum migration constituents of DZM.A lipotoxic cardiomyopathy rat model was established through high-fat diet and intervened by different doses of DZM.The cardiac function was assessed using echocardiography,and hematoxylin and eosin,oil red O,and Masson staining were conducted to evaluate morphological changes,lipid accumulation,and fibrosis in myocardial tissue.Serum myocardial enzyme activity,lipid levels,and lipid content of myocardial tissue were measured,while fluorescent staining and colorimetry were used to assess oxidation levels in myocardial tissue.Mitochondrial membrane potential was detected by 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethyl-imidacarbocyanineiodide(JC-1).Transmission electron microscopy was employed to observe ultrastructure and mitochondrial structure changes in myocardial tissue.Fluorescence double staining and colocalization were utilized to observe the binding of autophagosomes and mitochondria,while immunohistochemical staining was used to detect the expression of mitophagy-related proteins.Terminal deoxynucleoitidyl transferase mediated nick end labeling staining was employed for the identification of apoptosis in myocardial tissue,while quantitative real-time reverse transcriptase polymerase chain reaction(q RT-PCR)and Western blot were utilized for the detection of apoptosis,B-cell lymphoma-2 adenovirus E1B 19 k Da-interacting protein 3(BNIP3)/mitophagy signaling pathway-related genes and proteins.In palmitic acid-induced Rat H9C2 cardiomyocytes(H9c2)cells,various cellular parameters including cell viability,lactate dehydrogenase release,apoptosis rate,oxidative stress level,mitochondrial structure and function,and mitophagy level were assessed after the treatment of DZM drug-containing serum for a duration of 24 h.The cellular expressions of BNIP3/mitophagy signaling pathway relevant genes and proteins were further evaluated using q RT-PCR and Western blot techniques.RESULTS:A total of 295 prototypes(e.g.,phenolic acids,quinones,terpenoids)were identified in serum of rats after oral administration of DZM.In vivo,DZM therapy has been shown to effectively enhance cardiac function,mitigate high-fat diet-induced myocardial structural damage and lipid accumulation.Furthermore,DZM has demonstrated the ability to reduce lipid levels,attenuate cell apoptosis,combat oxidative stress,enhance mitochondrial structure and function,and activate the BNIP3/mitophagy signaling pathway.Furthermore,the silencing of BNIP3 has been shown to exacerbate palmitic acid-induced damages in H9c2 cells,while inhibiting the BNIP3/mitophagy signaling pathway can mitigate the inhibitory effects of DZM on palmitic acidinduced apoptosis,lipid deposition and oxidative stress.CONCLUSION:This study presents preliminary evidence for the therapeutic efficacy of DZM on lipotoxic cardiomyopathy through the activating BNIP3/mitophagy signaling pathway.
