Dear Editors,Radiation can result in DNA damage,excessive oxidative stress,inflammatory responses,and impaired immune function,1 further leading to damage to different systems.For example,radiation exposure during Com...Dear Editors,Radiation can result in DNA damage,excessive oxidative stress,inflammatory responses,and impaired immune function,1 further leading to damage to different systems.For example,radiation exposure during Computed Tomography increases the risk of leukemia in children.2 In addition,radiation therapy is one of the common treatment methods for cancer patients.However,radiation during the treatment process may cause upper and lower gastrointestinal mucositis,which can seriously affect the effectiveness of tumor treatment.3 At present,antiradiation drugs on the market include amifostine,sargramostim,and potassium iodide.However,these chemically synthesized drugs have certain side effects,such as hypotension,nausea,and vomiting.4 Therefore,in recent years,natural compounds with lower toxicity have attracted much attention as potential therapeutic agents against radiation damage.5 Licochalcone B,the main active substance of licorice(Glycyrrhiza uralensis Fisch.),has a variety of biological activities and pharmacological effects,including antioxidant,anti-inflammatory,anti-tumor,and immunomodulatory properties.6 Therefore,Licochalcone B may be a potential therapeutic agent against radiation damage.展开更多
基金funded by the Yangtze University Science and Technology Aid to Tibet Medical Talent Training Program Project(2023YZ13 to XCP)the National Innovation and Entrepreneurship Training Program for College Students(202310489021 to XCP)+1 种基金the Graduate Innovation Fund of the Health Science Center,Yangtze University(202303 to XCP)the Wujieping Medical Foundation-Digestive Tract Cancer Research Fund(320.6750.2024-10-3 to XCP).
文摘Dear Editors,Radiation can result in DNA damage,excessive oxidative stress,inflammatory responses,and impaired immune function,1 further leading to damage to different systems.For example,radiation exposure during Computed Tomography increases the risk of leukemia in children.2 In addition,radiation therapy is one of the common treatment methods for cancer patients.However,radiation during the treatment process may cause upper and lower gastrointestinal mucositis,which can seriously affect the effectiveness of tumor treatment.3 At present,antiradiation drugs on the market include amifostine,sargramostim,and potassium iodide.However,these chemically synthesized drugs have certain side effects,such as hypotension,nausea,and vomiting.4 Therefore,in recent years,natural compounds with lower toxicity have attracted much attention as potential therapeutic agents against radiation damage.5 Licochalcone B,the main active substance of licorice(Glycyrrhiza uralensis Fisch.),has a variety of biological activities and pharmacological effects,including antioxidant,anti-inflammatory,anti-tumor,and immunomodulatory properties.6 Therefore,Licochalcone B may be a potential therapeutic agent against radiation damage.
