Buckling failure in submarine cables presents a prevalent challenge in ocean engineering.This work aims to explore the buckling behavior of umbilical cables with damaged sheaths subjected to compression and bending cy...Buckling failure in submarine cables presents a prevalent challenge in ocean engineering.This work aims to explore the buckling behavior of umbilical cables with damaged sheaths subjected to compression and bending cyclic loads.A finite element model is devised,incorporating a singular armor wire,a rigid core,and a damaged sheath.To scrutinize the buckling progression and corresponding deformation,axial compression and bending cyclic loads are introduced.The observations reveal that a reduction in axial compression results in a larger number of cycles before buckling ensues and progressively shifts the buckling position toward the extrados and fixed end.Decreasing the bending radius precipitates a reduction in the buckling cycle number and minimizes the deformation in the armor wire.Furthermore,an empirical model is presented to predict the occurrence of birdcage buckling,providing a means to anticipate buckling events and to estimate the requisite number of cycles leading to buckling.展开更多
Investigating the combined effects of mining damage and creep damage on slope stability is crucial,as it can comprehensively reveal the non-linear deformation characteristics of rock under their joint influence.This s...Investigating the combined effects of mining damage and creep damage on slope stability is crucial,as it can comprehensively reveal the non-linear deformation characteristics of rock under their joint influence.This study develops a fractional-order nonlinear creep constitutive model that incorporates the double damage effect and implements a non-linear creep subroutine for soft rock using the threedimensional finite difference method on the FLAC3D platform.Comparative analysis of the theoretical,numerical,and experimental results reveals that the fractional-order constitutive model,which incorporates the double damage effect,accurately reflects the distinct deformation stages of green mudstone during creep failure and effectively captures the non-linear deformation in the accelerated creep phase.The numerical results show a fitting accuracy exceeding 97%with the creep test curves,significantly outperforming the 61%accuracy of traditional creep models.展开更多
As an evaluation index,the natural frequency has the advantages of easy acquisition and quantitative evaluation.In this paper,the natural frequency is used to evaluate the performance of external cable reinforced brid...As an evaluation index,the natural frequency has the advantages of easy acquisition and quantitative evaluation.In this paper,the natural frequency is used to evaluate the performance of external cable reinforced bridges.Numerical examples show that compared with the natural frequencies of first-order modes,the natural frequencies of higher-order modes are more sensitive and can reflect the damage situation and external cable reinforcement effect of T-beam bridges.For damaged bridges,as the damage to the T-beam increases,the natural frequency value of the bridge gradually decreases.When the degree of local damage to the beam reaches 60%,the amplitude of natural frequency change exceeds 10%for the first time.The natural frequencies of the firstorder vibration mode and higher-order vibration mode can be selected as indexes for different degrees of the damaged T-beam bridges.For damaged bridges reinforced with external cables,the traditional natural frequency of the first-order vibration mode cannot be used as the index,which is insensitive to changes in prestress of the external cable.Some natural frequencies of higher-order vibration modes can be selected as indexes,which can reflect the reinforcement effect of externally prestressed damaged T-beam bridges,and its numerical value increases with the increase of external prestressed cable force.展开更多
Rocks will suffer different degree of damage under freeze-thaw(FT)cycles,which seriously threatens the long-term stability of rock engineering in cold regions.In order to study the mechanism of rock FT damage,energy c...Rocks will suffer different degree of damage under freeze-thaw(FT)cycles,which seriously threatens the long-term stability of rock engineering in cold regions.In order to study the mechanism of rock FT damage,energy calculation method and energy self-inhibition model are introduced to explore their energy characteristics in this paper.The applicability of the energy self-inhibition model was verified by combining the data of FT cycles and uniaxial compression tests of intact and pre-cracked sandstone samples,as well as published reference data.In addition,the energy evolution characteristics of FT damaged rocks were discussed accordingly.The results indicate that the energy self-inhibition model perfectly characterizes the energy accumulation characteristics of FT damaged rocks under uniaxial compression before the peak strength and the energy dissipation characteristics before microcrack unstable growth stage.Taking the FT damaged cyan sandstone sample as an example,it has gone through two stages dominated by energy dissipation mechanism and energy accumulation mechanism,and the energy rate curve of the pre-cracked sample shows a fall-rise phenomenon when approaching failure.Based on the published reference data,it was found that the peak total input energy and energy storage limit conform to an exponential FT decay model,with corresponding decay constants ranging from 0.0021 to 0.1370 and 0.0018 to 0.1945,respectively.Finally,a linear energy storage equation for FT damaged rocks was proposed,and its high reliability and applicability were verified by combining published reference data,the energy storage coefficient of different types of rocks ranged from 0.823 to 0.992,showing a negative exponential relationship with the initial UCS(uniaxial compressive strength).In summary,the mechanism by which FT weakens the mechanical properties of rocks has been revealed from an energy perspective in this paper,which can provide reference for related issues in cold regions.展开更多
Excavation of underground caverns,such as mountain tunnels and energy-storage caverns,may cause the damages to the surrounding rock as a result of the stress redistribution.In this influenced zone,new cracks and disco...Excavation of underground caverns,such as mountain tunnels and energy-storage caverns,may cause the damages to the surrounding rock as a result of the stress redistribution.In this influenced zone,new cracks and discontinuities are created or propagate in the rock mass.Therefore,it is effective to measure and evaluate the acoustic emission(AE)events generated by the rocks,which is a small elastic vibration,and permeability change.The authors have developed a long-term measurement device that incorporates an optical AE(O-AE)sensor,an optical pore pressure sensor,and an optical temperature sensor in a single multi-optical measurement probe(MOP).Japan Atomic Energy Agency has been conducting R&D activities to enhance the reliability of high-level radioactive waste(HLW)deep geological disposal technology.In a high-level radioactive disposal project,one of the challenges is the development of methods for long-term monitoring of rock mass behavior.Therefore,in January 2014,the long-term measurements of the hydro-mechanical behavior of the rock mass were launched using the developed MOP in the vicinity of 350 m below the surface at the Horonobe Underground Research Center.The measurement results show that AEs occur frequently up to 1.5 m from the wall during excavation.In addition,hydraulic conductivity increased by 2e4 orders of magnitude.Elastoplastic analysis revealed that the hydraulic behavior of the rock mass affected the pore pressure fluctuations and caused micro-fractures.Based on this,a conceptual model is developed to represent the excavation damaged zone(EDZ),which contributes to the safe geological disposal of radioactive waste.展开更多
Underground excavation can lead to stress redistribution and result in an excavation damaged zone(EDZ),which is an important factor affecting the excavation stability and support design.Accurately estimating the thick...Underground excavation can lead to stress redistribution and result in an excavation damaged zone(EDZ),which is an important factor affecting the excavation stability and support design.Accurately estimating the thickness of EDZ is essential to ensure the safety of the underground excavation.In this study,four novel hybrid ensemble learning models were developed by optimizing the extreme gradient boosting(XGBoost)and random forest(RF)algorithms through simulated annealing(SA)and Bayesian optimization(BO)approaches,namely SA-XGBoost,SA-RF,BO XGBoost and BO-RF models.A total of 210 cases were collected from Xiangxi Gold Mine in Hunan Province and Fankou Lead-zinc Mine in Guangdong Province,China,including seven input indicators:embedding depth,drift span,uniaxial compressive strength of rock,rock mass rating,unit weight of rock,lateral pressure coefficient of roadway and unit consumption of blasting explosive.The performance of the proposed models was evaluated by the coefficient of determination,root mean squared error,mean absolute error and variance accounted for.The results indicated that the SA-XGBoost model performed best.The Shapley additive explanations method revealed that the embedding depth was the most important indicator.Moreover,the convergence curves suggested that the SA-XGBoost model can reduce the generalization error and avoid overfitting.展开更多
The influence of thermal damage on macroscopic and microscopic characteristics of different rocks has received much attention in the field of rock engineering.When the rocks are subjected to thermal treatment,the chan...The influence of thermal damage on macroscopic and microscopic characteristics of different rocks has received much attention in the field of rock engineering.When the rocks are subjected to thermal treatment,the change of macroscopic characteristics and evolution of micro-structure would be induced,ultimately resulting in different degrees of thermal damage in rocks.To better understand the thermal damage mechanism of different rocks and its effect on the rock performance,this study reviews a large number of test results of rock specimens experiencing heating and cooling treatment in the laboratory.Firstly,the variations of macroscopic behaviors,including physical parameters,mechanical parameters,thermal conductivity and permeability,are examined.The variations of mechanical parameters with thermal treatment variables(i.e.temperature or the number of thermal cycles)are divided into four types.Secondly,several measuring methods for microstructure,such as polarizing microscopy,fluorescent method,scanning electron microscopy(SEM),X-ray computerized tomography(CT),acoustic emission(AE)and ultrasonic technique,are introduced.Furthermore,the effect of thermal damage on the mechanical parameters of rocks in response to different thermal treatments,involving temperature magnitude,cooling method and thermal cycle,are discussed.Finally,the limitations and prospects for the research of rock thermal damage are proposed.展开更多
The 2022 M6.9 Menyuan earthquake caused severe damage to a high-speed railway bridge,which was designed for high-speed trains running at speeds of above 250 km/h and is located right next to the fault.Bridges of this ...The 2022 M6.9 Menyuan earthquake caused severe damage to a high-speed railway bridge,which was designed for high-speed trains running at speeds of above 250 km/h and is located right next to the fault.Bridges of this type have been widely used for rapidly constructing the high-speed railway network,but few bridges have been tested by near-fault devastating earthquakes.The potential severe impact of the earthquake on the high-speed railway is not only the safety of the infrastructure,trains and passengers,but also economic loss due to interrupted railway use.Therefore,a field survey was carried out immediately after the earthquake to collect time-sensitive data.The damage to the bridge was carefully investigated,and quantitative analyses were conducted to better understand the mechanism of the bridge failure.It was found that seismic action perpendicular to the bridge’s longitudinal direction caused severe damage to the girders and rails,while none of the piers showed obvious deformation or cracking.The maximum values of transverse displacement,out-of-plane rotation and twisting angle of girders reached 212.6 cm,3.1 degrees and 19.9 degrees,respectively,causing severe damage to the bearing supports and anti-seismic retaining blocks.These observations provide a basis for improving the seismic design of high-speed railway bridges located in near-fault areas.展开更多
A Ni-based solder BNi-5 was adopted as the repair agent to repair the prefabricated defects on the car-bon/carbon(C/C)composites.The effects of different heat-treatment(HT)temperatures and pre-oxidation on the chemica...A Ni-based solder BNi-5 was adopted as the repair agent to repair the prefabricated defects on the car-bon/carbon(C/C)composites.The effects of different heat-treatment(HT)temperatures and pre-oxidation on the chemical composition,microstructure,and mechanical behavior of the repaired C/C composites were investigated,and the repair mechanism was studied by finite element analysis methods.The repair agent and C/C composites were tightly bonded through mechanical interlocking and chemical reactions,and the flexural properties of the damaged C/C composites were significantly improved after repair.The products at the interface formed a gradient distribution structure of the thermal expansion coefficient when the HT temperature was 1300°C,which is beneficial to relieve the residual thermal stress at the interface.Meanwhile,the porosity of the surface of the C/C composites was higher after pre-oxidation,which led to more diffusion channels for the repair agent and enhanced the interface bonding ability.The flexural strength was the highest with a recovery rate of 85.2%when the C/C composites were pre-oxidized at 600°C and the HT temperature was 1300°C.This work provides a strategy for the engineering application of the damage repair of C/C composites.展开更多
Objective This study aimed to establish a neural cell injury model in vitro by stimulating PC12 cells with lipopolysaccharide(LPS)and to examine the effects of astragaloside IV on key targets using high-throughput seq...Objective This study aimed to establish a neural cell injury model in vitro by stimulating PC12 cells with lipopolysaccharide(LPS)and to examine the effects of astragaloside IV on key targets using high-throughput sequence technology and bioinformatics analyses.Methods PC12 cells in the logarithmic growth phase were treated with LPS at final concentrations of 0.25,0.5,0.75,1,and 1.25 mg/mL for 24 h.Cell morphology was evaluated,and cell survival rates were calculated.A neurocyte inflammatory model was established with LPS treatment,which reached a 50%cell survival rate.PC12 cells were treated with 0.01,0.1,1,10,or 100µmol/L astragaloside IV for 24 h.The concentration of astragaloside IV that did not affect the cell survival rate was selected as the treatment group for subsequent experiments.NOS activity was detected by colorimetry;the expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS and COX-2 mRNA and protein were detected by RT-qPCR and Western blotting.The differentially expressed genes(DEGs)between the groups were screened using a second-generation sequence(fold change>2,P<0.05)with the following KEGG enrichment analysis,RT-qPCR and Western blotting were used to detect the mRNA and protein expression of DEGs related to the IL-17 pathway in different groups of PC12 cells.Results The viability of PC12 cells was not altered by treatment with 0.01,0.1,or 1µmol/L astragaloside IV for 24 h(P>0.05).However,after treatment with 0.5,0.75,1,or 1.25 mg/mL LPS for 24 h,the viability steadily decreased(P<0.01).The mRNA and protein expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS,and COX-2 were significantly increased after PC12 cells were treated with 1 mg/mL LPS for 24 h(P<0.01);however,these changes were reversed when PC12 cells were pretreated with 0.01,0.1,or 1µmol/L astragaloside IV in PC12 cells and then treated with 1 mg/mL LPS for 24 h(P<0.05).Second-generation sequencing revealed that 1026 genes were upregulated,while 1287 genes were downregulated.The DEGs were associated with autophagy,TNF-α,interleukin-17,MAPK,P53,Toll-like receptor,and NOD-like receptor signaling pathways.Furthermore,PC12 cells treated with a 1 mg/mL LPS for 24 h exhibited increased mRNA and protein expression of CCL2,CCL11,CCL7,MMP3,and MMP10,which are associated with the IL-17 pathway.RT-qPCR and Western blotting analyses confirmed that the DEGs listed above corresponded to the sequence assay results.Conclusion LPS can damage PC12 cells and cause inflammatory reactions in nerve cells and DNA damage.astragaloside IV plays an anti-inflammatory and DNA damage protective role and inhibits the IL-17 signaling pathway to exert a neuroprotective effect in vitro.展开更多
Cells are surrounded by a double-layered phospholipid cell membrane responsible for the isolation of intracellular contents, active regulation of uptake from the extracellular environment, and intercellular connection...Cells are surrounded by a double-layered phospholipid cell membrane responsible for the isolation of intracellular contents, active regulation of uptake from the extracellular environment, and intercellular connection and communication. These cell membranes must be intact and functionally active for cell survival and biological functioning. Compromised damage repair mechanisms usually result in impaired cellular homeostasis, leading to early or late problems. Chronic myopathies, certain myocardial diseases, aging, and acute or chronic neurodegenerative diseases (like Parkinson and Alzheimer) are directly related to cell membrane damage. This study examined the effect of a cholesterol-loaded nanoparticle (methyl-beta cyclodextrin) or the silk protein sericin on cell membrane and DNA integrity and cell viability in an in vitro cell damage model (frozen-thawed rabbit sperm cells). The cells were stored in liquid nitrogen (-196°C), thawed in small batches, and treated with cholesterol-loaded cyclodextrin or sericin before incubation at 35°C for 4 hours. Cell membrane integrity, DNA damage, and viability rates were assessed immediately after thawing and after the incubation period. The administration of sericin and cholesterol in a cell damage model increased cell survival and reduced DNA damage over a 4-hour post-thaw incubation period, suggesting their potential use as a “first aid” intervention at the cellular level.展开更多
[Objective] The aim was to provide a reference for studying the resistant ability of subtropical forest to freeze disaster and detecting the recovery and evolution of Huodendron biaristatum species after freeze disast...[Objective] The aim was to provide a reference for studying the resistant ability of subtropical forest to freeze disaster and detecting the recovery and evolution of Huodendron biaristatum species after freeze disaster.[Method] Effects of the damage caused by the southern ice storm in early 2008 on Huodendron biaristatum,dominant species of evergreen broad-leaved forest on the Damingshan,were studied in the aspect of population ecology.[Result] Among the 1 090 Huodendron biaristatum individuals （DBH ≥ 1 cm）,697 individuals were victims,accounting for 63.9%.The largest part of the victims was crown breakdown,which took up 37.6%.13.0% of the victims were bent,and 10.2% of the victims were trunk broken.The least part of the victims were uprooted,accounting for only 3.1%.Different types and extent of forestry damage had remarkable differences in diameter class,tree height,crown and taper.Rates of damage and crown breakdown increased with the increase of DBH,while bent rate decreased.Rates of damage,bent and trunk broken declined slowly with the increase of tree height,while crown breakdown rate followed the normal distribution.As the crown level increased,rates of damage and crown breakdown increased,while the rate of trunk broken decreased.Individuals with high taper were more susceptible to crown damage,bending,breaking and uprooted.[Conclusion] The resistant ability of Huodendron biaristatum species to freeze disaster is affected by many factors like DBH,tree height,crown,taper,etc..Huodendron biaristatum species in Damingshan affected by those factors show various kinds of damaged types dominant by mechanical damage,but there is few individual to die.展开更多
[Objective] The aim of this study was to extract effective feature bands of damaged rice leaves by planthoppers to make identification and classification rapidly from great amounts of imaging spectral data. [Method] T...[Objective] The aim of this study was to extract effective feature bands of damaged rice leaves by planthoppers to make identification and classification rapidly from great amounts of imaging spectral data. [Method] The experiment, using multi-spectral imaging system, acquired the multi-spectral images of damaged rice leaves from band 400 to 720 nm by interval of 5 nm. [Result] According to the principle of band index, it was calculated that the bands at 515, 510, 710, 555, 630, 535, 505, 530 and 595 nm were having high band index value with rich information and little correlation. Furthermore, the experiment used two classification methods and calcu-lated the classification accuracy higher than 90.00% for feature bands and ful bands of damaged rice leaves by planthoppers respectively. [Conclusion] It can be con-cluded that these bands can be considered as effective feature bands to identify damaged rice leaves by planthoppers quickly from a large scale of crops.展开更多
A method was proposed to evaluate the real-time reliability for a single product based on damaged measurement degradation data.Most researches on degradation analysis often assumed that the measurement process did not...A method was proposed to evaluate the real-time reliability for a single product based on damaged measurement degradation data.Most researches on degradation analysis often assumed that the measurement process did not have any impact on the product's performance.However,in some cases,the measurement process may exert extra stress on products being measured.To obtain trustful results in such a situation,a new degradation model was derived.Then,by fusing the prior information of product and its own on-line degradation data,the real-time reliability was evaluated on the basis of Bayesian formula.To make the proposed method more practical,a procedure based on expectation maximization (EM) algorithm was presented to estimate the unknown parameters.Finally,the performance of the proposed method was illustrated by a simulation study.The results show that ignoring the influence of the damaged measurement process can lead to biased evaluation results,if the damaged measurement process is involved.展开更多
Deep underground excavations within hard rocks can result in damage to the surrounding rock mass mostly due to redistribution of stresses.Especially within rock masses with non-persistent joints,the role of the pre-ex...Deep underground excavations within hard rocks can result in damage to the surrounding rock mass mostly due to redistribution of stresses.Especially within rock masses with non-persistent joints,the role of the pre-existing joints in the damage evolution around the underground opening is of critical importance as they govern the fracturing mechanisms and influence the brittle responses of these hard rock masses under highly anisotropic in situ stresses.In this study,the main focus is the impact of joint network geometry,joint strength and applied field stresses on the rock mass behaviours and the evolution of excavation induced damage due to the loss of confinement as a tunnel face advances.Analysis of such a phenomenon was conducted using the finite-discrete element method(FDEM).The numerical model is initially calibrated in order to match the behaviour of the fracture-free,massive Lac du Bonnet granite during the excavation of the Underground Research Laboratory(URL)Test Tunnel,Canada.The influence of the pre-existing joints on the rock mass response during excavation is investigated by integrating discrete fracture networks(DFNs)of various characteristics into the numerical models under varying in situ stresses.The numerical results obtained highlight the significance of the pre-existing joints on the reduction of in situ rock mass strength and its capacity for extension with both factors controlling the brittle response of the material.Furthermore,the impact of spatial distribution of natural joints on the stability of an underground excavation is discussed,as well as the potentially minor influence of joint strength on the stress induced damage within joint systems of a non-persistent nature under specific conditions.Additionally,the in situ stress-joint network interaction is examined,revealing the complex fracturing mechanisms that may lead to uncontrolled fracture propagation that compromises the overall stability of an underground excavation.展开更多
in order to evaluate the capacity of reinforced concrete （RC） structures subjected to blast Ioadings, the damaged plasticity model for concrete was used in the analysis of the dynamic responses of blast-loaded RC st...in order to evaluate the capacity of reinforced concrete （RC） structures subjected to blast Ioadings, the damaged plasticity model for concrete was used in the analysis of the dynamic responses of blast-loaded RC structures, and all three failure modes were numerically simulated by the finite element software ABAQUS. Simulation results agree with the experimental observations. It is demonstrated that the damaged plasticity model for concrete in the finite element software ABAQUS can predict dynamic responses and typical flexure, flexure-shear and direct shear failure modes of the blast-loaded RC structures.展开更多
Excavation Damaged Zone(EDZ)scope is important for optimizing excavation and support schemes in deep underground caverns.However,accurately predicting the full EDZ scope within the surrounding rock masses of deep unde...Excavation Damaged Zone(EDZ)scope is important for optimizing excavation and support schemes in deep underground caverns.However,accurately predicting the full EDZ scope within the surrounding rock masses of deep underground caverns during excavation remains a pressing problem.This study presents a comprehensive EDZ scope prediction approach(CESPA)for the brittle surrounding rock masses of deep underground caverns by coupling numerical simulation with quantitative analysis of borehole wall images and ultrasonic test results.First,the changes in both P-velocity(V_(p))and joint distribution of the surrounding rock masses before and after excavation damage are captured using ultrasonic tests and borehole digital cameras.Second,the quality Q-parameters of the surrounding rock mass before and after excavation damage are preliminarily rated with the rock mass descriptions provided by borehole wall images,and the rock mass V_(p)-parameter values are determined according to the V_(p)-borehole depth curves.Third,the Q-parameter ratings are further finely adjusted by updating the related Q-values to be similar with the Q-values estimated by V_(p)-parameter values.Fourth,the initial and residual mechanical parameters for the rock mass deterioration model(RDM)are estimated by the adjusted Q-parameter ratings based on the modified Q-based relations,and the elastic modulus deterioration index(EDI)threshold to describe the EDZ boundary is determined with the V_(p)-parameter values.Finally,EDZ scope is predicted using the elastoplastic numerical simulation with RDM and EDI based on the mechanical parameter estimates and EDI threshold.Analyses of applications in Sub-lab D1 in Jinping II project show that CESPA can provide a reliable and operable solution for predicting full EDZ scopes within the brittle surrounding rock masses of deep underground caverns.展开更多
Rhythmic oscillatory patterns sustain cellular dynamics,driving the concerted action of regulatory molecules,microtubules,and molecular motors.We describe cellular microtubules as oscillators capable of synchronizatio...Rhythmic oscillatory patterns sustain cellular dynamics,driving the concerted action of regulatory molecules,microtubules,and molecular motors.We describe cellular microtubules as oscillators capable of synchronization and swarming,generating mechanical and electric patterns that impact biomolecular recognition.We consider the biological relevance of seeing the inside of cells populated by a network of molecules that behave as bioelectronic circuits and chromophores.We discuss the novel perspectives disclosed by mechanobiology,bioelectromagnetism,and photobiomodulation,both in term of fundamental basic science and in light of the biomedical implication of using physical energies to govern(stem)cell fate.We focus on the feasibility of exploiting atomic force microscopy and hyperspectral imaging to detect signatures of nanomotions and electromagnetic radiation(light),respectively,generated by the stem cells across the specification of their multilineage repertoire.The chance is reported of using these signatures and the diffusive features of physical waves to direct specifically the differentiation program of stem cells in situ,where they already are resident in all the tissues of the human body.We discuss how this strategy may pave the way to a regenerative and precision medicine without the needs for(stem)cell or tissue transplantation.We describe a novel paradigm based upon boosting our inherent ability for self-healing.展开更多
Research on the permeability and pressure distribution characteristics of the roadway surrounding rock in the excavation damaged zone(EDZ) is beneficial for the development of gas control technology. In this study, an...Research on the permeability and pressure distribution characteristics of the roadway surrounding rock in the excavation damaged zone(EDZ) is beneficial for the development of gas control technology. In this study, analytical solutions of stress and strain of the roadway surrounding rock were obtained, in which the creep deformation and strain softening were considered. Using the MTS815 rock mechanics testing system and a gas permeability testing system, permeability tests were conducted in the complete stress-strain process, and the evolution characteristics of permeability and strain were studied over the whole loading process. Based on the analytical solutions of stress and strain and the governing equation of gas seepage flow, this paper proposes a hydro-mechanical(HM) model, which considers three different zones around the roadway. Then the gas flow process in the roadway surrounding rock in three different zones was simulated according to the engineering geological conditions, thus obtaining the permeability and pressure distribution characteristics of the roadway surrounding rock in three different zones. These results show that the surrounding rock around the roadway can be divided into four regions-the full flow zone(FFZ), flow-shielding zone(FSZ), transitive flow zone(TFZ), and in-situ rock flow zone(IRFZ). These results could provide theoretical guidance for the improvement of gas extraction and gas control technology.展开更多
The damaged and strain subsurface layers of semi insulating(SI) GaAs substrate were characterized non destructively by Raman back scattering.The study shows that the thicknesses of the damaged and strain layers are...The damaged and strain subsurface layers of semi insulating(SI) GaAs substrate were characterized non destructively by Raman back scattering.The study shows that the thicknesses of the damaged and strain layers are less than 3μm.The damaged and strain layer can be removed after being etched in H 2SO 4·H 2O 2·H 2O for 1.5 min.展开更多
基金financially supported by the National Natural Science Foundation of China(Grant No.52471301)the Fujian Province Transportation Science and Technology Project(Grant No.JC202302)the Zhejiang Provincial Natural Science Foundation of China(Grant No.LY24E090003).
文摘Buckling failure in submarine cables presents a prevalent challenge in ocean engineering.This work aims to explore the buckling behavior of umbilical cables with damaged sheaths subjected to compression and bending cyclic loads.A finite element model is devised,incorporating a singular armor wire,a rigid core,and a damaged sheath.To scrutinize the buckling progression and corresponding deformation,axial compression and bending cyclic loads are introduced.The observations reveal that a reduction in axial compression results in a larger number of cycles before buckling ensues and progressively shifts the buckling position toward the extrados and fixed end.Decreasing the bending radius precipitates a reduction in the buckling cycle number and minimizes the deformation in the armor wire.Furthermore,an empirical model is presented to predict the occurrence of birdcage buckling,providing a means to anticipate buckling events and to estimate the requisite number of cycles leading to buckling.
基金support from the National Natural Science Foundation of China(No.52308316)the Scientific Research Foundation of Weifang University(Grant No.2024BS42)+2 种基金China Postdoctoral Science Foundation(No.2022M721885)the Key Laboratory of Rock Mechanics and Geohazards of Zhejiang Province(No.ZJRMG-2022-01)supported by Open Research Fund of State Key Laboratory of Geomechanics and Geotechnical Engineering,Institute of Rock and Soil Mechanics,Chinese Academy of Sciences(NO.SKLGME023017).
文摘Investigating the combined effects of mining damage and creep damage on slope stability is crucial,as it can comprehensively reveal the non-linear deformation characteristics of rock under their joint influence.This study develops a fractional-order nonlinear creep constitutive model that incorporates the double damage effect and implements a non-linear creep subroutine for soft rock using the threedimensional finite difference method on the FLAC3D platform.Comparative analysis of the theoretical,numerical,and experimental results reveals that the fractional-order constitutive model,which incorporates the double damage effect,accurately reflects the distinct deformation stages of green mudstone during creep failure and effectively captures the non-linear deformation in the accelerated creep phase.The numerical results show a fitting accuracy exceeding 97%with the creep test curves,significantly outperforming the 61%accuracy of traditional creep models.
基金supported by Henan Province Science and Technology Research Funding Project(No.222102320129)the Key Research Project of Henan Higher Education Institutions(Grant Nos.22A560004,22A56005).
文摘As an evaluation index,the natural frequency has the advantages of easy acquisition and quantitative evaluation.In this paper,the natural frequency is used to evaluate the performance of external cable reinforced bridges.Numerical examples show that compared with the natural frequencies of first-order modes,the natural frequencies of higher-order modes are more sensitive and can reflect the damage situation and external cable reinforcement effect of T-beam bridges.For damaged bridges,as the damage to the T-beam increases,the natural frequency value of the bridge gradually decreases.When the degree of local damage to the beam reaches 60%,the amplitude of natural frequency change exceeds 10%for the first time.The natural frequencies of the firstorder vibration mode and higher-order vibration mode can be selected as indexes for different degrees of the damaged T-beam bridges.For damaged bridges reinforced with external cables,the traditional natural frequency of the first-order vibration mode cannot be used as the index,which is insensitive to changes in prestress of the external cable.Some natural frequencies of higher-order vibration modes can be selected as indexes,which can reflect the reinforcement effect of externally prestressed damaged T-beam bridges,and its numerical value increases with the increase of external prestressed cable force.
基金Project(52174088)supported by the National Natural Science Foundation of ChinaProject(104972024JYS0007)supported by the Independent Innovation Research Fund Graduate Free Exploration,Wuhan University of Technology,China。
文摘Rocks will suffer different degree of damage under freeze-thaw(FT)cycles,which seriously threatens the long-term stability of rock engineering in cold regions.In order to study the mechanism of rock FT damage,energy calculation method and energy self-inhibition model are introduced to explore their energy characteristics in this paper.The applicability of the energy self-inhibition model was verified by combining the data of FT cycles and uniaxial compression tests of intact and pre-cracked sandstone samples,as well as published reference data.In addition,the energy evolution characteristics of FT damaged rocks were discussed accordingly.The results indicate that the energy self-inhibition model perfectly characterizes the energy accumulation characteristics of FT damaged rocks under uniaxial compression before the peak strength and the energy dissipation characteristics before microcrack unstable growth stage.Taking the FT damaged cyan sandstone sample as an example,it has gone through two stages dominated by energy dissipation mechanism and energy accumulation mechanism,and the energy rate curve of the pre-cracked sample shows a fall-rise phenomenon when approaching failure.Based on the published reference data,it was found that the peak total input energy and energy storage limit conform to an exponential FT decay model,with corresponding decay constants ranging from 0.0021 to 0.1370 and 0.0018 to 0.1945,respectively.Finally,a linear energy storage equation for FT damaged rocks was proposed,and its high reliability and applicability were verified by combining published reference data,the energy storage coefficient of different types of rocks ranged from 0.823 to 0.992,showing a negative exponential relationship with the initial UCS(uniaxial compressive strength).In summary,the mechanism by which FT weakens the mechanical properties of rocks has been revealed from an energy perspective in this paper,which can provide reference for related issues in cold regions.
文摘Excavation of underground caverns,such as mountain tunnels and energy-storage caverns,may cause the damages to the surrounding rock as a result of the stress redistribution.In this influenced zone,new cracks and discontinuities are created or propagate in the rock mass.Therefore,it is effective to measure and evaluate the acoustic emission(AE)events generated by the rocks,which is a small elastic vibration,and permeability change.The authors have developed a long-term measurement device that incorporates an optical AE(O-AE)sensor,an optical pore pressure sensor,and an optical temperature sensor in a single multi-optical measurement probe(MOP).Japan Atomic Energy Agency has been conducting R&D activities to enhance the reliability of high-level radioactive waste(HLW)deep geological disposal technology.In a high-level radioactive disposal project,one of the challenges is the development of methods for long-term monitoring of rock mass behavior.Therefore,in January 2014,the long-term measurements of the hydro-mechanical behavior of the rock mass were launched using the developed MOP in the vicinity of 350 m below the surface at the Horonobe Underground Research Center.The measurement results show that AEs occur frequently up to 1.5 m from the wall during excavation.In addition,hydraulic conductivity increased by 2e4 orders of magnitude.Elastoplastic analysis revealed that the hydraulic behavior of the rock mass affected the pore pressure fluctuations and caused micro-fractures.Based on this,a conceptual model is developed to represent the excavation damaged zone(EDZ),which contributes to the safe geological disposal of radioactive waste.
基金Project(52204117)supported by the National Natural Science Foundation of ChinaProject(2022JJ40601)supported by the Natural Science Foundation of Hunan Province,China。
文摘Underground excavation can lead to stress redistribution and result in an excavation damaged zone(EDZ),which is an important factor affecting the excavation stability and support design.Accurately estimating the thickness of EDZ is essential to ensure the safety of the underground excavation.In this study,four novel hybrid ensemble learning models were developed by optimizing the extreme gradient boosting(XGBoost)and random forest(RF)algorithms through simulated annealing(SA)and Bayesian optimization(BO)approaches,namely SA-XGBoost,SA-RF,BO XGBoost and BO-RF models.A total of 210 cases were collected from Xiangxi Gold Mine in Hunan Province and Fankou Lead-zinc Mine in Guangdong Province,China,including seven input indicators:embedding depth,drift span,uniaxial compressive strength of rock,rock mass rating,unit weight of rock,lateral pressure coefficient of roadway and unit consumption of blasting explosive.The performance of the proposed models was evaluated by the coefficient of determination,root mean squared error,mean absolute error and variance accounted for.The results indicated that the SA-XGBoost model performed best.The Shapley additive explanations method revealed that the embedding depth was the most important indicator.Moreover,the convergence curves suggested that the SA-XGBoost model can reduce the generalization error and avoid overfitting.
基金supported by the National Key Research and Development Plan(Grant No.2022YFC2905700)Natural Science Foundation of Anhui Province(Grant No.2208085ME120)Key Research and Development Plan of Anhui Province(Grant No.2022m07020001).
文摘The influence of thermal damage on macroscopic and microscopic characteristics of different rocks has received much attention in the field of rock engineering.When the rocks are subjected to thermal treatment,the change of macroscopic characteristics and evolution of micro-structure would be induced,ultimately resulting in different degrees of thermal damage in rocks.To better understand the thermal damage mechanism of different rocks and its effect on the rock performance,this study reviews a large number of test results of rock specimens experiencing heating and cooling treatment in the laboratory.Firstly,the variations of macroscopic behaviors,including physical parameters,mechanical parameters,thermal conductivity and permeability,are examined.The variations of mechanical parameters with thermal treatment variables(i.e.temperature or the number of thermal cycles)are divided into four types.Secondly,several measuring methods for microstructure,such as polarizing microscopy,fluorescent method,scanning electron microscopy(SEM),X-ray computerized tomography(CT),acoustic emission(AE)and ultrasonic technique,are introduced.Furthermore,the effect of thermal damage on the mechanical parameters of rocks in response to different thermal treatments,involving temperature magnitude,cooling method and thermal cycle,are discussed.Finally,the limitations and prospects for the research of rock thermal damage are proposed.
基金Scientific Research Funding of IEM under Grant No.2021EEEVL0211Natural Science Foundation of Heilongjiang Province under Grant No.JQ2021E006National Natural Science Foundation of China under Grant No.52208185。
文摘The 2022 M6.9 Menyuan earthquake caused severe damage to a high-speed railway bridge,which was designed for high-speed trains running at speeds of above 250 km/h and is located right next to the fault.Bridges of this type have been widely used for rapidly constructing the high-speed railway network,but few bridges have been tested by near-fault devastating earthquakes.The potential severe impact of the earthquake on the high-speed railway is not only the safety of the infrastructure,trains and passengers,but also economic loss due to interrupted railway use.Therefore,a field survey was carried out immediately after the earthquake to collect time-sensitive data.The damage to the bridge was carefully investigated,and quantitative analyses were conducted to better understand the mechanism of the bridge failure.It was found that seismic action perpendicular to the bridge’s longitudinal direction caused severe damage to the girders and rails,while none of the piers showed obvious deformation or cracking.The maximum values of transverse displacement,out-of-plane rotation and twisting angle of girders reached 212.6 cm,3.1 degrees and 19.9 degrees,respectively,causing severe damage to the bearing supports and anti-seismic retaining blocks.These observations provide a basis for improving the seismic design of high-speed railway bridges located in near-fault areas.
基金supported by the National Key R&D Program of China(Nos.2021YFA0715800,2021YFA0715803)the Science Center for Gas Turbine Project(No.P2021-A-IV-003-001)the National Natural Science Foundation of China(No.52125203).
文摘A Ni-based solder BNi-5 was adopted as the repair agent to repair the prefabricated defects on the car-bon/carbon(C/C)composites.The effects of different heat-treatment(HT)temperatures and pre-oxidation on the chemical composition,microstructure,and mechanical behavior of the repaired C/C composites were investigated,and the repair mechanism was studied by finite element analysis methods.The repair agent and C/C composites were tightly bonded through mechanical interlocking and chemical reactions,and the flexural properties of the damaged C/C composites were significantly improved after repair.The products at the interface formed a gradient distribution structure of the thermal expansion coefficient when the HT temperature was 1300°C,which is beneficial to relieve the residual thermal stress at the interface.Meanwhile,the porosity of the surface of the C/C composites was higher after pre-oxidation,which led to more diffusion channels for the repair agent and enhanced the interface bonding ability.The flexural strength was the highest with a recovery rate of 85.2%when the C/C composites were pre-oxidized at 600°C and the HT temperature was 1300°C.This work provides a strategy for the engineering application of the damage repair of C/C composites.
基金supported by grants from Open Project of Gansu Traditional Chinese Medicine Research Center(No.zyzx-2020-10)Gansu Province Youth Science and Technology Foundation Program(No.21JR7RA652)+1 种基金Gansu Province Higher Education Research(No.2018A-049)Gansu Province Higher Education Research(No.2021B-163).
文摘Objective This study aimed to establish a neural cell injury model in vitro by stimulating PC12 cells with lipopolysaccharide(LPS)and to examine the effects of astragaloside IV on key targets using high-throughput sequence technology and bioinformatics analyses.Methods PC12 cells in the logarithmic growth phase were treated with LPS at final concentrations of 0.25,0.5,0.75,1,and 1.25 mg/mL for 24 h.Cell morphology was evaluated,and cell survival rates were calculated.A neurocyte inflammatory model was established with LPS treatment,which reached a 50%cell survival rate.PC12 cells were treated with 0.01,0.1,1,10,or 100µmol/L astragaloside IV for 24 h.The concentration of astragaloside IV that did not affect the cell survival rate was selected as the treatment group for subsequent experiments.NOS activity was detected by colorimetry;the expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS and COX-2 mRNA and protein were detected by RT-qPCR and Western blotting.The differentially expressed genes(DEGs)between the groups were screened using a second-generation sequence(fold change>2,P<0.05)with the following KEGG enrichment analysis,RT-qPCR and Western blotting were used to detect the mRNA and protein expression of DEGs related to the IL-17 pathway in different groups of PC12 cells.Results The viability of PC12 cells was not altered by treatment with 0.01,0.1,or 1µmol/L astragaloside IV for 24 h(P>0.05).However,after treatment with 0.5,0.75,1,or 1.25 mg/mL LPS for 24 h,the viability steadily decreased(P<0.01).The mRNA and protein expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS,and COX-2 were significantly increased after PC12 cells were treated with 1 mg/mL LPS for 24 h(P<0.01);however,these changes were reversed when PC12 cells were pretreated with 0.01,0.1,or 1µmol/L astragaloside IV in PC12 cells and then treated with 1 mg/mL LPS for 24 h(P<0.05).Second-generation sequencing revealed that 1026 genes were upregulated,while 1287 genes were downregulated.The DEGs were associated with autophagy,TNF-α,interleukin-17,MAPK,P53,Toll-like receptor,and NOD-like receptor signaling pathways.Furthermore,PC12 cells treated with a 1 mg/mL LPS for 24 h exhibited increased mRNA and protein expression of CCL2,CCL11,CCL7,MMP3,and MMP10,which are associated with the IL-17 pathway.RT-qPCR and Western blotting analyses confirmed that the DEGs listed above corresponded to the sequence assay results.Conclusion LPS can damage PC12 cells and cause inflammatory reactions in nerve cells and DNA damage.astragaloside IV plays an anti-inflammatory and DNA damage protective role and inhibits the IL-17 signaling pathway to exert a neuroprotective effect in vitro.
文摘Cells are surrounded by a double-layered phospholipid cell membrane responsible for the isolation of intracellular contents, active regulation of uptake from the extracellular environment, and intercellular connection and communication. These cell membranes must be intact and functionally active for cell survival and biological functioning. Compromised damage repair mechanisms usually result in impaired cellular homeostasis, leading to early or late problems. Chronic myopathies, certain myocardial diseases, aging, and acute or chronic neurodegenerative diseases (like Parkinson and Alzheimer) are directly related to cell membrane damage. This study examined the effect of a cholesterol-loaded nanoparticle (methyl-beta cyclodextrin) or the silk protein sericin on cell membrane and DNA integrity and cell viability in an in vitro cell damage model (frozen-thawed rabbit sperm cells). The cells were stored in liquid nitrogen (-196°C), thawed in small batches, and treated with cholesterol-loaded cyclodextrin or sericin before incubation at 35°C for 4 hours. Cell membrane integrity, DNA damage, and viability rates were assessed immediately after thawing and after the incubation period. The administration of sericin and cholesterol in a cell damage model increased cell survival and reduced DNA damage over a 4-hour post-thaw incubation period, suggesting their potential use as a “first aid” intervention at the cellular level.
基金Support by National Natural Science Foundation of China(30860059)~~
文摘[Objective] The aim was to provide a reference for studying the resistant ability of subtropical forest to freeze disaster and detecting the recovery and evolution of Huodendron biaristatum species after freeze disaster.[Method] Effects of the damage caused by the southern ice storm in early 2008 on Huodendron biaristatum,dominant species of evergreen broad-leaved forest on the Damingshan,were studied in the aspect of population ecology.[Result] Among the 1 090 Huodendron biaristatum individuals （DBH ≥ 1 cm）,697 individuals were victims,accounting for 63.9%.The largest part of the victims was crown breakdown,which took up 37.6%.13.0% of the victims were bent,and 10.2% of the victims were trunk broken.The least part of the victims were uprooted,accounting for only 3.1%.Different types and extent of forestry damage had remarkable differences in diameter class,tree height,crown and taper.Rates of damage and crown breakdown increased with the increase of DBH,while bent rate decreased.Rates of damage,bent and trunk broken declined slowly with the increase of tree height,while crown breakdown rate followed the normal distribution.As the crown level increased,rates of damage and crown breakdown increased,while the rate of trunk broken decreased.Individuals with high taper were more susceptible to crown damage,bending,breaking and uprooted.[Conclusion] The resistant ability of Huodendron biaristatum species to freeze disaster is affected by many factors like DBH,tree height,crown,taper,etc..Huodendron biaristatum species in Damingshan affected by those factors show various kinds of damaged types dominant by mechanical damage,but there is few individual to die.
基金Supported by National Natural Science Foundation of China under Grant(No.60968001,61168003)Natural Science Foundation of Yunnan Province under Grant(No.2011FZ079,2009CD047)National Training Programs of Innovation and Entrepreneurship for Undergraduates under Grant(No.201210681005,201310681004)~~
文摘[Objective] The aim of this study was to extract effective feature bands of damaged rice leaves by planthoppers to make identification and classification rapidly from great amounts of imaging spectral data. [Method] The experiment, using multi-spectral imaging system, acquired the multi-spectral images of damaged rice leaves from band 400 to 720 nm by interval of 5 nm. [Result] According to the principle of band index, it was calculated that the bands at 515, 510, 710, 555, 630, 535, 505, 530 and 595 nm were having high band index value with rich information and little correlation. Furthermore, the experiment used two classification methods and calcu-lated the classification accuracy higher than 90.00% for feature bands and ful bands of damaged rice leaves by planthoppers respectively. [Conclusion] It can be con-cluded that these bands can be considered as effective feature bands to identify damaged rice leaves by planthoppers quickly from a large scale of crops.
基金Project(60904002)supported by the National Natural Science Foundation of China
文摘A method was proposed to evaluate the real-time reliability for a single product based on damaged measurement degradation data.Most researches on degradation analysis often assumed that the measurement process did not have any impact on the product's performance.However,in some cases,the measurement process may exert extra stress on products being measured.To obtain trustful results in such a situation,a new degradation model was derived.Then,by fusing the prior information of product and its own on-line degradation data,the real-time reliability was evaluated on the basis of Bayesian formula.To make the proposed method more practical,a procedure based on expectation maximization (EM) algorithm was presented to estimate the unknown parameters.Finally,the performance of the proposed method was illustrated by a simulation study.The results show that ignoring the influence of the damaged measurement process can lead to biased evaluation results,if the damaged measurement process is involved.
基金the Natural Sciences and Engineering Research Council of Canadathe Ministry of National Defensethe RMC Green Team for providing the funding and the resources
文摘Deep underground excavations within hard rocks can result in damage to the surrounding rock mass mostly due to redistribution of stresses.Especially within rock masses with non-persistent joints,the role of the pre-existing joints in the damage evolution around the underground opening is of critical importance as they govern the fracturing mechanisms and influence the brittle responses of these hard rock masses under highly anisotropic in situ stresses.In this study,the main focus is the impact of joint network geometry,joint strength and applied field stresses on the rock mass behaviours and the evolution of excavation induced damage due to the loss of confinement as a tunnel face advances.Analysis of such a phenomenon was conducted using the finite-discrete element method(FDEM).The numerical model is initially calibrated in order to match the behaviour of the fracture-free,massive Lac du Bonnet granite during the excavation of the Underground Research Laboratory(URL)Test Tunnel,Canada.The influence of the pre-existing joints on the rock mass response during excavation is investigated by integrating discrete fracture networks(DFNs)of various characteristics into the numerical models under varying in situ stresses.The numerical results obtained highlight the significance of the pre-existing joints on the reduction of in situ rock mass strength and its capacity for extension with both factors controlling the brittle response of the material.Furthermore,the impact of spatial distribution of natural joints on the stability of an underground excavation is discussed,as well as the potentially minor influence of joint strength on the stress induced damage within joint systems of a non-persistent nature under specific conditions.Additionally,the in situ stress-joint network interaction is examined,revealing the complex fracturing mechanisms that may lead to uncontrolled fracture propagation that compromises the overall stability of an underground excavation.
基金Supported by National Natural Science Foundation of China (No.50638030 and 50525825)National Science and Technology Support Program (No.2006BAJ13B02).
文摘in order to evaluate the capacity of reinforced concrete （RC） structures subjected to blast Ioadings, the damaged plasticity model for concrete was used in the analysis of the dynamic responses of blast-loaded RC structures, and all three failure modes were numerically simulated by the finite element software ABAQUS. Simulation results agree with the experimental observations. It is demonstrated that the damaged plasticity model for concrete in the finite element software ABAQUS can predict dynamic responses and typical flexure, flexure-shear and direct shear failure modes of the blast-loaded RC structures.
基金funded by the National Natural Science Foundation of China under Grant Nos.51979268,U1765206,41877256。
文摘Excavation Damaged Zone(EDZ)scope is important for optimizing excavation and support schemes in deep underground caverns.However,accurately predicting the full EDZ scope within the surrounding rock masses of deep underground caverns during excavation remains a pressing problem.This study presents a comprehensive EDZ scope prediction approach(CESPA)for the brittle surrounding rock masses of deep underground caverns by coupling numerical simulation with quantitative analysis of borehole wall images and ultrasonic test results.First,the changes in both P-velocity(V_(p))and joint distribution of the surrounding rock masses before and after excavation damage are captured using ultrasonic tests and borehole digital cameras.Second,the quality Q-parameters of the surrounding rock mass before and after excavation damage are preliminarily rated with the rock mass descriptions provided by borehole wall images,and the rock mass V_(p)-parameter values are determined according to the V_(p)-borehole depth curves.Third,the Q-parameter ratings are further finely adjusted by updating the related Q-values to be similar with the Q-values estimated by V_(p)-parameter values.Fourth,the initial and residual mechanical parameters for the rock mass deterioration model(RDM)are estimated by the adjusted Q-parameter ratings based on the modified Q-based relations,and the elastic modulus deterioration index(EDI)threshold to describe the EDZ boundary is determined with the V_(p)-parameter values.Finally,EDZ scope is predicted using the elastoplastic numerical simulation with RDM and EDI based on the mechanical parameter estimates and EDI threshold.Analyses of applications in Sub-lab D1 in Jinping II project show that CESPA can provide a reliable and operable solution for predicting full EDZ scopes within the brittle surrounding rock masses of deep underground caverns.
文摘Rhythmic oscillatory patterns sustain cellular dynamics,driving the concerted action of regulatory molecules,microtubules,and molecular motors.We describe cellular microtubules as oscillators capable of synchronization and swarming,generating mechanical and electric patterns that impact biomolecular recognition.We consider the biological relevance of seeing the inside of cells populated by a network of molecules that behave as bioelectronic circuits and chromophores.We discuss the novel perspectives disclosed by mechanobiology,bioelectromagnetism,and photobiomodulation,both in term of fundamental basic science and in light of the biomedical implication of using physical energies to govern(stem)cell fate.We focus on the feasibility of exploiting atomic force microscopy and hyperspectral imaging to detect signatures of nanomotions and electromagnetic radiation(light),respectively,generated by the stem cells across the specification of their multilineage repertoire.The chance is reported of using these signatures and the diffusive features of physical waves to direct specifically the differentiation program of stem cells in situ,where they already are resident in all the tissues of the human body.We discuss how this strategy may pave the way to a regenerative and precision medicine without the needs for(stem)cell or tissue transplantation.We describe a novel paradigm based upon boosting our inherent ability for self-healing.
基金financially supported by the Natural Science Foundation of Jiangsu Province,China(No.BK20140189)the Postdoctoral Science Foundation of China(No.2014M550315)
文摘Research on the permeability and pressure distribution characteristics of the roadway surrounding rock in the excavation damaged zone(EDZ) is beneficial for the development of gas control technology. In this study, analytical solutions of stress and strain of the roadway surrounding rock were obtained, in which the creep deformation and strain softening were considered. Using the MTS815 rock mechanics testing system and a gas permeability testing system, permeability tests were conducted in the complete stress-strain process, and the evolution characteristics of permeability and strain were studied over the whole loading process. Based on the analytical solutions of stress and strain and the governing equation of gas seepage flow, this paper proposes a hydro-mechanical(HM) model, which considers three different zones around the roadway. Then the gas flow process in the roadway surrounding rock in three different zones was simulated according to the engineering geological conditions, thus obtaining the permeability and pressure distribution characteristics of the roadway surrounding rock in three different zones. These results show that the surrounding rock around the roadway can be divided into four regions-the full flow zone(FFZ), flow-shielding zone(FSZ), transitive flow zone(TFZ), and in-situ rock flow zone(IRFZ). These results could provide theoretical guidance for the improvement of gas extraction and gas control technology.
文摘The damaged and strain subsurface layers of semi insulating(SI) GaAs substrate were characterized non destructively by Raman back scattering.The study shows that the thicknesses of the damaged and strain layers are less than 3μm.The damaged and strain layer can be removed after being etched in H 2SO 4·H 2O 2·H 2O for 1.5 min.
