Thermomechanical Fatigue (TMF) is one of the most dangerous failure modes of high-temperature structures. The effect of coarsened and rafted microstructures on the TMF behavior of Nickel-Base Single Crystal Superalloy...Thermomechanical Fatigue (TMF) is one of the most dangerous failure modes of high-temperature structures. The effect of coarsened and rafted microstructures on the TMF behavior of Nickel-Base Single Crystal Superalloys (NBSX) was experimentally studied. TMF tests under In-Phase (IP) and Out-of-Phase (OP) paths revealed significant variations in TMF life reduction. Cyclic deformation behaviors of alloys with different microstructures were compared. The effect of microstructure on TMF damage mechanisms was unveiled from characterizations of fracture surfaces and longitudinal sections by scanning electronic microscope and optical microscope. A transition from mode-I to crystallographic fracture in the coarsened alloy during IP-TMF was observed and discussed. Due to the degraded microstructure, the dispersed distribution of crystal slips was distinguished in the coarsened and rafted alloys. The competitive or synergetic interactions among oxidation-assisted mode-I opening, casting pore-related mode-I creep and crystallographic slipping were discussed. This study underscores the complex interplay among microstructure, deformation behaviors and damage mechanisms, offering valuable insights into alloy performance under TMF conditions.展开更多
The change in surface damage/microstructures and its effects on the hydrogen(H)isotope/helium(He)dynamic behavior are the key factors for investigating issues of tungsten(W)-based plasma-facing materials(PFMs)in fusio...The change in surface damage/microstructures and its effects on the hydrogen(H)isotope/helium(He)dynamic behavior are the key factors for investigating issues of tungsten(W)-based plasma-facing materials(PFMs)in fusion such as surface erosion,H/He retention and tritium(T)inventory.Complex surface damage/microstructures are introduced in W by high-temperature plasma irradiation and new material design,typically including pre-damage and multi-ion co-deposition induced structures,solute elements and related composites,native defects like dislocations and interfaces,and nanostructures.Systematic experimental and theoretical researches were performed on H isotope/He retention in complex W-based materials in the past decades.In this review,we aim to provide an overview of typical surface damage/microstructures and their effects on H/He retention in W,both in the experiment and multiscale modeling.The distribution/state,dynamics evolution,and interaction with defects/microstructures of H/He are generally summarized at different scales.Finally,the current difficulties,challenges and future directions are also discussed about H/He retention in complex W-based PFMs.展开更多
Retinal ganglion cells are the bridging neurons between the eye and the central nervous system,transmitting visual signals to the brain.The injury and loss of retinal ganglion cells are the primary pathological change...Retinal ganglion cells are the bridging neurons between the eye and the central nervous system,transmitting visual signals to the brain.The injury and loss of retinal ganglion cells are the primary pathological changes in several retinal degenerative diseases,including glaucoma,ischemic optic neuropathy,diabetic neuropathy,and optic neuritis.In mammals,injured retinal ganglion cells lack regenerative capacity and undergo apoptotic cell death within a few days of injury.Additionally,these cells exhibit limited regenerative ability,ultimately contributing to vision impairment and potentially leading to blindness.Currently,the only effective clinical treatment for glaucoma is to prevent vision loss by lowering intraocular pressure through medications or surgery;however,this approach cannot halt the effect of retinal ganglion cell loss on visual function.This review comprehensively investigates the mechanisms underlying retinal ganglion cell degeneration in retinal degenerative diseases and further explores the current status and potential of cell replacement therapy for regenerating retinal ganglion cells.As our understanding of the complex processes involved in retinal ganglion cell degeneration deepens,we can explore new treatment strategies,such as cell transplantation,which may offer more effective ways to mitigate the effect of retinal degenerative diseases on vision.展开更多
To accurately predict the fatigue properties of additively manufactured(AM)titanium alloys,it is important to understand the fatigue damage origin behavior.However,this behavior is still ambiguous.Therefore,the effect...To accurately predict the fatigue properties of additively manufactured(AM)titanium alloys,it is important to understand the fatigue damage origin behavior.However,this behavior is still ambiguous.Therefore,the effects of internal defects and microstructures on the fatigue damage origin behavior of laser direct energy deposited TC11(LDED-TC11)alloy were investigated using a fatigue origin criterion.The criterion was proposed to analyze the competing and combining effects by coupling the plasticity-corrected crack driving force,the resistance of short cracks,and the modified Kitagawa-Takahashi diagram.Three scenarios corresponding to the criterion were clarified,representing the damage mechanisms dominated by the microstructure,the combined effect of internal defect and microstructure,and the internal defect.As a result,the fatigue fracture morphology of high-cycle fatigue tests demonstrates two fatigue origin modes,i.e.microstructure and gas pore origin modes.The two fatigue modes belong to Scenario I and Scenario II,respectively,which indicates that the fatigue damage origin process of this alloy is sensitive to microstructure.Besides,it was found that the width of the primary a phase of this alloy is strongly relevant to intrinsic defect size.Finally,the fatigue origin criterion was verified in three aspects.展开更多
In order to investigate the damage tolerance of a metastable Ti-5Al-3V-3Mo-2Cr-2Zr-1Nb-1Fe(Ti5321)alloy with bimodal microstructure using void growth quantification and micromechanical modeling,in situ tensile testing...In order to investigate the damage tolerance of a metastable Ti-5Al-3V-3Mo-2Cr-2Zr-1Nb-1Fe(Ti5321)alloy with bimodal microstructure using void growth quantification and micromechanical modeling,in situ tensile testing was performed during X-ray microtomography experiments.Compared with investigations of surface voids by traditional two-dimensional(2D)methods involving post-mortem characterization,three-dimensional(3D)information on void evolution inside optically opaque samples obtained through X-ray microtomography is essential.The Rice and Tracey model and Huang model were applied to predict void growth and show good agreement with experimental data using calibration of the damage parameterα.The void growth kinetics of Ti5321 with bimodal microstructure was analyzed by comparing theαvalue with that of Ti64 for different microstructure morphologies.The damage mechanism of ductile fracture of Ti5321 with bimodal microstructure is discussed.It was found that the size of the voids apparently increases with the triaxiality of stress.Post-mortem scanning electron microscopy(SEM)was also used to demonstrate this damage mechanism of ductile fracture of Ti5321.展开更多
Turbine blades of gas turbine engines usually suffer from severe operational conditions characterized by high temperature and stress. Severe operational conditions during service cause microstructural changes in turbi...Turbine blades of gas turbine engines usually suffer from severe operational conditions characterized by high temperature and stress. Severe operational conditions during service cause microstructural changes in turbine blades and degrade their mechanical properties. In this study, service-induced microstructural damages in serviced turbine blades manufactured from a directionally solidified superalloy were evaluated. The observed microstructural damage of the turbine blade mainly involves the coarsening and rafting of γ' precipitates. The leading edge of 60% height of the turbine blades undergone most severe microstructural damage with significant microstructural evolution at this area. Microstructural damage affects the mechanical properties such as Vickers hardness, that is,Vickers hardness decreases as the equivalent diameter decreases. Microstructural damage shows great positiondependent feature as service temperature and radial stress on blade changes. With the aid of energy-dispersive spectrometer(EDS) analysis on carbide, the transformation of carbide does not exist. In addition, no topological closed-packed phase exists in the turbine blade.展开更多
The depth and nature of the subsurface damage in a silicon wafer will limit the performance of IC components. Damage microstructures of the silicon wafers ground by the #325, #600, and #2000 grinding wheels was analyz...The depth and nature of the subsurface damage in a silicon wafer will limit the performance of IC components. Damage microstructures of the silicon wafers ground by the #325, #600, and #2000 grinding wheels was analyzed. The results show that many microcracks, fractures, and dislocation rosettes appear in the surface and subsurface of the wafer ground by the #325 grinding wheel. No obvious microstructure change exists. The amorphous layer with a thickness of about 100 nm, microcracks, high density dislocations, and polycrystalline silicon are observed in the subsurface of the wafer ground by the #600 grinding wheel. For the wafer ground by the #2000 grinding wheel, an amorphous layer of about 30 nm thickness, a polycrystalline silicon layer, a few dislocations, and an elastic deformation layer exist. In general, with the decrease in grit size, the material removal mode changes from micro-fracture mode to ductile mode gradually.展开更多
Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters accordi...Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientific basis for structural damage identification and dynamic model modification.In view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and briefly describes how to identify structural damages based on the derived modal parameters.The paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),briefly describes damage identification methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artificial intelligence(AI)methods in the direction of modal parameter recognition and damage identification is further discussed.Based on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identification methods are given to provide scientific references for the optimized design and functional upgrading of SHM systems.展开更多
The microstructures and mechanical properties of Al-8.3Zn-3.3Cu-2.2Mg alloys prepared via hot extrusion and liquid forging methods were investigated.Results show that based on DEFORM simulation analysis,the optimal ho...The microstructures and mechanical properties of Al-8.3Zn-3.3Cu-2.2Mg alloys prepared via hot extrusion and liquid forging methods were investigated.Results show that based on DEFORM simulation analysis,the optimal hot extrusion parameters are determined as ingot initial temperature of 380°C and extrusion speed of 3 mm/s.The hot-extruded aluminum alloy after T6 heat treatment presents superior mechanical properties with yield strength of 519.6 MPa,ultimate tensile strength of 582.1 MPa,and elongation of 11.0%.Compared with the properties of gravity-cast and liquid-forged alloys,the yield strength of hot-extruded alloy increases by 30.8%and 4.9%,and the ultimate tensile strength improves by 43.5%and 10.2%,respectively.The significant improvement in tensile strength of the hot-extruded alloys is attributed to the elimination of casting defects and the refinement of matrix grain and eutectic phases.In addition,the hot-extruded alloy demonstrates superior plasticity compared with the liquid-forged alloy.This is because severe plastic deformation occurs during hot extrusion,which effectively breaks and disperses the eutectic phases,facilitating the dissolution and precipitation of the second phases and inhibiting the microcrack initiation.展开更多
The effect of different intermediate annealing heat treatments on the surface microstructures and anodic oxide film structures of rolled Al-5.6Mg sheets was studied.The results show that when the continuous annealing ...The effect of different intermediate annealing heat treatments on the surface microstructures and anodic oxide film structures of rolled Al-5.6Mg sheets was studied.The results show that when the continuous annealing is used to control microstructures of the sheets instead of the static state annealing in the intermediate annealing process,the surface grain size of the sheets can be reduced by about 65.7%,and the size of the Mg precipitation phase(Mg_(2)Al_(3))can be reduced by about 67%.Under the combined influence of grain size,precipitation phase,and texture,the highest glossiness can be obtained,which is attributed to continuous intermediate annealing and stabilization annealing at low temperature.The uniform grain and precipitation structures is beneficial to reducing the inhomogeneous dissolution of the oxide film and to obtain the anodic oxide film with uniform thickness and high glossiness.展开更多
11Cr-0.4Mo-2W-CuVNb steel （ASME Gr.122） is used for boiler components in ultra- supercritical （USC） thermal power plants. The creep strength of high-Cr steel welds decreases due to the formation of Type IV creep d...11Cr-0.4Mo-2W-CuVNb steel （ASME Gr.122） is used for boiler components in ultra- supercritical （USC） thermal power plants. The creep strength of high-Cr steel welds decreases due to the formation of Type IV creep damage in the heat-affected zone （HAZ） during long-term use at high temperatures. In the present study, the processes and mechanisms of Type Ⅳ creep damage were elucidated by investigating the long-term creep strength, microstructure and damage behavior of Gr.122 steel welds. Creep tests using thick welded joints were interrupted at several time steps, and the initiation, evolution and distribution of creep damage were measured. It was found that the formation and growth of creep damage was suppressed during the steady- state stage; creep voids formed at 0.5 of life, and coalesced to form a crack after 0.9 of life. Type IV creep damage was mostly observed in the area about 30% below the surface of the plate. Differences in creep damage behavior between Gr.122 and Gr.91 steel welds were examined. Experimental creep damage distribution was compared with computed versions using the finite element method and damage mechanics.展开更多
Effects of γ， η precipitates and grain size on hydrogen damage (HD) of JBK-75 precipitate-strengthened austenitic steel were examined using the method of high-pressure thermal hydrogen charging and tensile tests. T...Effects of γ， η precipitates and grain size on hydrogen damage (HD) of JBK-75 precipitate-strengthened austenitic steel were examined using the method of high-pressure thermal hydrogen charging and tensile tests. The hydrogen content in the charged specimens was 25.2 wppm. At the condition of η phase-free precipitating, the HD of the steel increased with increasing γ size, fine spherical γ dispersively dis-tributed was beneficial to improve the hydrogen-resistant property. η-phae precipitated at grain boundary increased HD tendency, while intragranular cellular η had less effect on it. Fine austenitic gruin Aize was beneficial to decrease the HD. At the condition of η phase-free precipitating, both hydrogen changed and uncharyed specimens of the steel fractured in ductile transgranular mode, whilst hydrogen promoted the intergranular fracture when obvious η precipitates were found.展开更多
Investigating the combined effects of mining damage and creep damage on slope stability is crucial,as it can comprehensively reveal the non-linear deformation characteristics of rock under their joint influence.This s...Investigating the combined effects of mining damage and creep damage on slope stability is crucial,as it can comprehensively reveal the non-linear deformation characteristics of rock under their joint influence.This study develops a fractional-order nonlinear creep constitutive model that incorporates the double damage effect and implements a non-linear creep subroutine for soft rock using the threedimensional finite difference method on the FLAC3D platform.Comparative analysis of the theoretical,numerical,and experimental results reveals that the fractional-order constitutive model,which incorporates the double damage effect,accurately reflects the distinct deformation stages of green mudstone during creep failure and effectively captures the non-linear deformation in the accelerated creep phase.The numerical results show a fitting accuracy exceeding 97%with the creep test curves,significantly outperforming the 61%accuracy of traditional creep models.展开更多
The electromigration induced microstructure evolution and damage in asymmetric Cu/Sn-58Bi/Cu solder interconnects were investigated by in-situ SEM observation, focused ion beam （FIB） microanalysis and finite element...The electromigration induced microstructure evolution and damage in asymmetric Cu/Sn-58Bi/Cu solder interconnects were investigated by in-situ SEM observation, focused ion beam （FIB） microanalysis and finite element （FE） simulation. The SEM results show that the electromigration-induced local degradation of microstructures, i.e., segregation of Bi-rich phase and formation of microcracks, in the asymmetric solder interconnects is much severer than that in the symmetrical ones. FIB-SEM microanalysis reveals that the microregional heterogeneity in electrical resistance along different electron flowing paths is the key factor leading to non-uniform current distribution and the resultant electromigration damage. Theoretical analysis and FE simulation results manifest that the current crowding easily occurs at the local part with smaller resistance in an asymmetric solder interconnect. All results indicate that the asymmetric shape of the solder interconnect brings about the difference of the electrical resistance between the different microregions and further results in the severe electromigration damage.展开更多
A plate of dual phase steel was produced from low carbon steel with intercritical annealing treatment. Its optically determined surface microstructure was utilized to construct three different microstructural models. ...A plate of dual phase steel was produced from low carbon steel with intercritical annealing treatment. Its optically determined surface microstructure was utilized to construct three different microstructural models. To describe the ductile damage in the ferritic matrix, the Gurson-Tvergaard-Needleman model was used with the failure in the martensite phase being ignored. The numerical results obtained for the mechanism of void initiation and coalescence were compared with the experimental observations. The numerical results obtained from the randomly extruded 3D model showed a significantly better agreement with the experimental ones than those obtained from the 2D model or the uniformly extruded 3D model.展开更多
Coral reef limestone(CRL)constitutes a distinctive marine carbonate formation with complex mechanical properties.This study investigates the multiscale damage and fracture mechanisms of CRL through integrated experime...Coral reef limestone(CRL)constitutes a distinctive marine carbonate formation with complex mechanical properties.This study investigates the multiscale damage and fracture mechanisms of CRL through integrated experimental testing,digital core technology,and theoretical modelling.Two CRL types with contrasting mesostructures were characterized across three scales.Macroscopically,CRL-I and CRL-II exhibited mean compressive strengths of 8.46 and 5.17 MPa,respectively.Mesoscopically,CRL-I featured small-scale highly interconnected pores,whilst CRL-II developed larger stratified pores with diminished connectivity.Microscopically,both CRL matrices demonstrated remarkable similarity in mineral composition and mechanical properties.A novel voxel average-based digital core scaling methodology was developed to facilitate numerical simulation of cross-scale damage processes,revealing network-progressive failure in CRL-I versus directional-brittle failure in CRL-II.Furthermore,a damage statistical constitutive model based on digital core technology and mesoscopic homogenisation theory established quantitative relationships between microelement strength distribution and macroscopic mechanical behavior.These findings illuminate the fundamental mechanisms through which mesoscopic structure governs the macroscopic mechanical properties of CRL.展开更多
The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in Braz...The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in Brazil.Yet,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.展开更多
We present an in-depth study of the failure phenomenon of solid expandable tubular (SET) due to large expansion ratio in open holes of deep and ultra-deep wells. By examining the post-expansion SET, lots of microcrack...We present an in-depth study of the failure phenomenon of solid expandable tubular (SET) due to large expansion ratio in open holes of deep and ultra-deep wells. By examining the post-expansion SET, lots of microcracks are found on the inner surface of SET. Their morphology and parameters such as length and depth are investigated by use of metallographic microscope and scanning electron microscope (SEM). In addition, the Voronoi cell technique is adopted to characterize the multi-phase material microstructure of the SET. By using the anisotropic elastoplastic material constitutive model and macro/microscopic multi-dimensional cross-scale coupled boundary conditions, a sophisticated and multi-scale finite element model (FEM) of the SET is built successfully to simulate the material microstructure damage for different expansion ratios. The microcrack initiation and growth is simulated, and the structural integrity of the SET is discussed. It is concluded that this multi-scale finite element modeling method could effectively predict the elastoplastic deformation and the microscopic damage initiation and evolution of the SET. It is of great significance as a theoretical analysis tool to optimize the selection of appropriate tubular materials and it could be also used to substantially reduce costly failures of expandable tubulars in the field. This numerical analysis is not only beneficial for understanding the damage process of tubular materials but also effectively guides the engineering application of the SET technology.展开更多
The DDR(DNA damage response)is an essential cellular mechanism that detects and repairs DNA lesions to maintain genomic stability.Dysregulation of DDR pathways is frequently observed in human tumors,leading to increas...The DDR(DNA damage response)is an essential cellular mechanism that detects and repairs DNA lesions to maintain genomic stability.Dysregulation of DDR pathways is frequently observed in human tumors,leading to increased genomic instability and promoting tumor progression.Consequently,targeting DDR mechanisms has emerged as a promising therapeutic strategy in oncology.This review provides an overview of the major DDR pathways,highlighting the roles of key proteins involved in various DDR processes.A detailed understanding of these molecular mechanisms has paved the way for the development of targeted antitumor agents,including inhibitors of PARP1,ATM,ATR,CHK1,CHK2,DNA-PK,and WEE1.Additionally,the significant challenges in the development of DDR inhibitors are examined,including tumor microenvironment heterogeneity,resistance mechanisms,issues with selectivity and toxicity,and the complexities associated with clinical trial design.Finally,future directions and emerging strategies to improve DDR-targeted therapies are discussed.These strategies include biomarker-driven precision medicine,novel combination therapies,advanced drug delivery systems,and the potential application of artificial intelligence to optimize treatment outcomes.展开更多
To verify the wear resistance and erosion resistance of Ti-doped Ta_(2)O_(5)coating(TTO),a series of TTOs were prepared by magnetron sputtering technology by controlling the power of the Ti target.The change of growth...To verify the wear resistance and erosion resistance of Ti-doped Ta_(2)O_(5)coating(TTO),a series of TTOs were prepared by magnetron sputtering technology by controlling the power of the Ti target.The change of growth structure,microstructure,and tribological properties of TTOs with Ti target power was studied.After the erosion test,the variation of erosion damage behavior of TTOs with mechanical properties under different erosion conditions was further studied.The results show that the TTOs eliminate the roughness,voids,and defects in the material due to the mobility of the adsorbed atoms during the growth process,and a flat and dense smooth surface is obtained.Tribological tests show that the TTOs are mainly characterized by plastic deformation and microcrack wear mechanism.Higher Ti target power can improve the wear resistance of TTOs.Erosion test results reveal that the impact crater,furrow,micro-cutting,brittle spalling,and crack formation are the main wear mechanisms of the TTOs samples under erosion conditions.展开更多
基金financed by the National Natural Science Foundation of China(Nos.12402071,92160204)the China Postdoctoral Science Foundation(No.2024M751635)+1 种基金the Postdoctoral Fellowship Program of CPSF,China(No.GZB20240365)the National Science and Technology Major Projects of China(No.J2019-IV-0011-0079).
文摘Thermomechanical Fatigue (TMF) is one of the most dangerous failure modes of high-temperature structures. The effect of coarsened and rafted microstructures on the TMF behavior of Nickel-Base Single Crystal Superalloys (NBSX) was experimentally studied. TMF tests under In-Phase (IP) and Out-of-Phase (OP) paths revealed significant variations in TMF life reduction. Cyclic deformation behaviors of alloys with different microstructures were compared. The effect of microstructure on TMF damage mechanisms was unveiled from characterizations of fracture surfaces and longitudinal sections by scanning electronic microscope and optical microscope. A transition from mode-I to crystallographic fracture in the coarsened alloy during IP-TMF was observed and discussed. Due to the degraded microstructure, the dispersed distribution of crystal slips was distinguished in the coarsened and rafted alloys. The competitive or synergetic interactions among oxidation-assisted mode-I opening, casting pore-related mode-I creep and crystallographic slipping were discussed. This study underscores the complex interplay among microstructure, deformation behaviors and damage mechanisms, offering valuable insights into alloy performance under TMF conditions.
基金This work was financially supported by the National Natural Science Foundation of China(Grant Nos.11975018,11775254 and 11534012)the National Magnetic Confinement Fusion Energy Research Project(Grant No.2018YEF0308100)+2 种基金the Science Challenge Project(Grant No.TZ2018004)the Youth Innovation Promotion Association of Chinese Academy of Sciences(CAS)(Grant No.2016386)Director Grants of Hefei Institutes of Physics Science,Chinese Academy of Sciences(CASHIPS).
文摘The change in surface damage/microstructures and its effects on the hydrogen(H)isotope/helium(He)dynamic behavior are the key factors for investigating issues of tungsten(W)-based plasma-facing materials(PFMs)in fusion such as surface erosion,H/He retention and tritium(T)inventory.Complex surface damage/microstructures are introduced in W by high-temperature plasma irradiation and new material design,typically including pre-damage and multi-ion co-deposition induced structures,solute elements and related composites,native defects like dislocations and interfaces,and nanostructures.Systematic experimental and theoretical researches were performed on H isotope/He retention in complex W-based materials in the past decades.In this review,we aim to provide an overview of typical surface damage/microstructures and their effects on H/He retention in W,both in the experiment and multiscale modeling.The distribution/state,dynamics evolution,and interaction with defects/microstructures of H/He are generally summarized at different scales.Finally,the current difficulties,challenges and future directions are also discussed about H/He retention in complex W-based PFMs.
基金supported by the National Key Research and Development Program of China,No.2019YFA0111200the National Natural Science Foundation of China,Nos.U23A20436,82371047+3 种基金Key Research Project in Shanxi Province,No.202302130501008Shanxi Provincial Science Fund for Distinguished Young Scholars,No.202103021221008Key Research and Development Program in Shanxi Province,No.202204051001023Shanxi Medical University Doctor’s Startup Fund Project,No.SD22028(all to YG)。
文摘Retinal ganglion cells are the bridging neurons between the eye and the central nervous system,transmitting visual signals to the brain.The injury and loss of retinal ganglion cells are the primary pathological changes in several retinal degenerative diseases,including glaucoma,ischemic optic neuropathy,diabetic neuropathy,and optic neuritis.In mammals,injured retinal ganglion cells lack regenerative capacity and undergo apoptotic cell death within a few days of injury.Additionally,these cells exhibit limited regenerative ability,ultimately contributing to vision impairment and potentially leading to blindness.Currently,the only effective clinical treatment for glaucoma is to prevent vision loss by lowering intraocular pressure through medications or surgery;however,this approach cannot halt the effect of retinal ganglion cell loss on visual function.This review comprehensively investigates the mechanisms underlying retinal ganglion cell degeneration in retinal degenerative diseases and further explores the current status and potential of cell replacement therapy for regenerating retinal ganglion cells.As our understanding of the complex processes involved in retinal ganglion cell degeneration deepens,we can explore new treatment strategies,such as cell transplantation,which may offer more effective ways to mitigate the effect of retinal degenerative diseases on vision.
基金supported by the National Natural Science Foundation of China(Nos.5175018,52090044)the 2025 Science and Technology Innovation Program of Ningbo,China(No.2022Z014)。
文摘To accurately predict the fatigue properties of additively manufactured(AM)titanium alloys,it is important to understand the fatigue damage origin behavior.However,this behavior is still ambiguous.Therefore,the effects of internal defects and microstructures on the fatigue damage origin behavior of laser direct energy deposited TC11(LDED-TC11)alloy were investigated using a fatigue origin criterion.The criterion was proposed to analyze the competing and combining effects by coupling the plasticity-corrected crack driving force,the resistance of short cracks,and the modified Kitagawa-Takahashi diagram.Three scenarios corresponding to the criterion were clarified,representing the damage mechanisms dominated by the microstructure,the combined effect of internal defect and microstructure,and the internal defect.As a result,the fatigue fracture morphology of high-cycle fatigue tests demonstrates two fatigue origin modes,i.e.microstructure and gas pore origin modes.The two fatigue modes belong to Scenario I and Scenario II,respectively,which indicates that the fatigue damage origin process of this alloy is sensitive to microstructure.Besides,it was found that the width of the primary a phase of this alloy is strongly relevant to intrinsic defect size.Finally,the fatigue origin criterion was verified in three aspects.
基金supported by the China Postdoctoral Science Foundation(No.2022M720399).
文摘In order to investigate the damage tolerance of a metastable Ti-5Al-3V-3Mo-2Cr-2Zr-1Nb-1Fe(Ti5321)alloy with bimodal microstructure using void growth quantification and micromechanical modeling,in situ tensile testing was performed during X-ray microtomography experiments.Compared with investigations of surface voids by traditional two-dimensional(2D)methods involving post-mortem characterization,three-dimensional(3D)information on void evolution inside optically opaque samples obtained through X-ray microtomography is essential.The Rice and Tracey model and Huang model were applied to predict void growth and show good agreement with experimental data using calibration of the damage parameterα.The void growth kinetics of Ti5321 with bimodal microstructure was analyzed by comparing theαvalue with that of Ti64 for different microstructure morphologies.The damage mechanism of ductile fracture of Ti5321 with bimodal microstructure is discussed.It was found that the size of the voids apparently increases with the triaxiality of stress.Post-mortem scanning electron microscopy(SEM)was also used to demonstrate this damage mechanism of ductile fracture of Ti5321.
基金financially supported by the National Basic Research Program of China (No. 2015CB057401)
文摘Turbine blades of gas turbine engines usually suffer from severe operational conditions characterized by high temperature and stress. Severe operational conditions during service cause microstructural changes in turbine blades and degrade their mechanical properties. In this study, service-induced microstructural damages in serviced turbine blades manufactured from a directionally solidified superalloy were evaluated. The observed microstructural damage of the turbine blade mainly involves the coarsening and rafting of γ' precipitates. The leading edge of 60% height of the turbine blades undergone most severe microstructural damage with significant microstructural evolution at this area. Microstructural damage affects the mechanical properties such as Vickers hardness, that is,Vickers hardness decreases as the equivalent diameter decreases. Microstructural damage shows great positiondependent feature as service temperature and radial stress on blade changes. With the aid of energy-dispersive spectrometer(EDS) analysis on carbide, the transformation of carbide does not exist. In addition, no topological closed-packed phase exists in the turbine blade.
基金This study was financially supported by the National Natural Science Foundation of China in Major Project Program (No. 50390061)the National Science Fund for Distinguished Young Scholars (No. 50325518).
文摘The depth and nature of the subsurface damage in a silicon wafer will limit the performance of IC components. Damage microstructures of the silicon wafers ground by the #325, #600, and #2000 grinding wheels was analyzed. The results show that many microcracks, fractures, and dislocation rosettes appear in the surface and subsurface of the wafer ground by the #325 grinding wheel. No obvious microstructure change exists. The amorphous layer with a thickness of about 100 nm, microcracks, high density dislocations, and polycrystalline silicon are observed in the subsurface of the wafer ground by the #600 grinding wheel. For the wafer ground by the #2000 grinding wheel, an amorphous layer of about 30 nm thickness, a polycrystalline silicon layer, a few dislocations, and an elastic deformation layer exist. In general, with the decrease in grit size, the material removal mode changes from micro-fracture mode to ductile mode gradually.
基金supported by the Innovation Foundation of Provincial Education Department of Gansu(2024B-005)the Gansu Province National Science Foundation(22YF7GA182)the Fundamental Research Funds for the Central Universities(No.lzujbky2022-kb01)。
文摘Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientific basis for structural damage identification and dynamic model modification.In view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and briefly describes how to identify structural damages based on the derived modal parameters.The paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),briefly describes damage identification methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artificial intelligence(AI)methods in the direction of modal parameter recognition and damage identification is further discussed.Based on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identification methods are given to provide scientific references for the optimized design and functional upgrading of SHM systems.
基金Natural Science Foundation of Shandong Province of China(ZR2023QE193)。
文摘The microstructures and mechanical properties of Al-8.3Zn-3.3Cu-2.2Mg alloys prepared via hot extrusion and liquid forging methods were investigated.Results show that based on DEFORM simulation analysis,the optimal hot extrusion parameters are determined as ingot initial temperature of 380°C and extrusion speed of 3 mm/s.The hot-extruded aluminum alloy after T6 heat treatment presents superior mechanical properties with yield strength of 519.6 MPa,ultimate tensile strength of 582.1 MPa,and elongation of 11.0%.Compared with the properties of gravity-cast and liquid-forged alloys,the yield strength of hot-extruded alloy increases by 30.8%and 4.9%,and the ultimate tensile strength improves by 43.5%and 10.2%,respectively.The significant improvement in tensile strength of the hot-extruded alloys is attributed to the elimination of casting defects and the refinement of matrix grain and eutectic phases.In addition,the hot-extruded alloy demonstrates superior plasticity compared with the liquid-forged alloy.This is because severe plastic deformation occurs during hot extrusion,which effectively breaks and disperses the eutectic phases,facilitating the dissolution and precipitation of the second phases and inhibiting the microcrack initiation.
文摘The effect of different intermediate annealing heat treatments on the surface microstructures and anodic oxide film structures of rolled Al-5.6Mg sheets was studied.The results show that when the continuous annealing is used to control microstructures of the sheets instead of the static state annealing in the intermediate annealing process,the surface grain size of the sheets can be reduced by about 65.7%,and the size of the Mg precipitation phase(Mg_(2)Al_(3))can be reduced by about 67%.Under the combined influence of grain size,precipitation phase,and texture,the highest glossiness can be obtained,which is attributed to continuous intermediate annealing and stabilization annealing at low temperature.The uniform grain and precipitation structures is beneficial to reducing the inhomogeneous dissolution of the oxide film and to obtain the anodic oxide film with uniform thickness and high glossiness.
文摘11Cr-0.4Mo-2W-CuVNb steel （ASME Gr.122） is used for boiler components in ultra- supercritical （USC） thermal power plants. The creep strength of high-Cr steel welds decreases due to the formation of Type IV creep damage in the heat-affected zone （HAZ） during long-term use at high temperatures. In the present study, the processes and mechanisms of Type Ⅳ creep damage were elucidated by investigating the long-term creep strength, microstructure and damage behavior of Gr.122 steel welds. Creep tests using thick welded joints were interrupted at several time steps, and the initiation, evolution and distribution of creep damage were measured. It was found that the formation and growth of creep damage was suppressed during the steady- state stage; creep voids formed at 0.5 of life, and coalesced to form a crack after 0.9 of life. Type IV creep damage was mostly observed in the area about 30% below the surface of the plate. Differences in creep damage behavior between Gr.122 and Gr.91 steel welds were examined. Experimental creep damage distribution was compared with computed versions using the finite element method and damage mechanics.
文摘Effects of γ， η precipitates and grain size on hydrogen damage (HD) of JBK-75 precipitate-strengthened austenitic steel were examined using the method of high-pressure thermal hydrogen charging and tensile tests. The hydrogen content in the charged specimens was 25.2 wppm. At the condition of η phase-free precipitating, the HD of the steel increased with increasing γ size, fine spherical γ dispersively dis-tributed was beneficial to improve the hydrogen-resistant property. η-phae precipitated at grain boundary increased HD tendency, while intragranular cellular η had less effect on it. Fine austenitic gruin Aize was beneficial to decrease the HD. At the condition of η phase-free precipitating, both hydrogen changed and uncharyed specimens of the steel fractured in ductile transgranular mode, whilst hydrogen promoted the intergranular fracture when obvious η precipitates were found.
基金support from the National Natural Science Foundation of China(No.52308316)the Scientific Research Foundation of Weifang University(Grant No.2024BS42)+2 种基金China Postdoctoral Science Foundation(No.2022M721885)the Key Laboratory of Rock Mechanics and Geohazards of Zhejiang Province(No.ZJRMG-2022-01)supported by Open Research Fund of State Key Laboratory of Geomechanics and Geotechnical Engineering,Institute of Rock and Soil Mechanics,Chinese Academy of Sciences(NO.SKLGME023017).
文摘Investigating the combined effects of mining damage and creep damage on slope stability is crucial,as it can comprehensively reveal the non-linear deformation characteristics of rock under their joint influence.This study develops a fractional-order nonlinear creep constitutive model that incorporates the double damage effect and implements a non-linear creep subroutine for soft rock using the threedimensional finite difference method on the FLAC3D platform.Comparative analysis of the theoretical,numerical,and experimental results reveals that the fractional-order constitutive model,which incorporates the double damage effect,accurately reflects the distinct deformation stages of green mudstone during creep failure and effectively captures the non-linear deformation in the accelerated creep phase.The numerical results show a fitting accuracy exceeding 97%with the creep test curves,significantly outperforming the 61%accuracy of traditional creep models.
基金Project(51275178)supported by the National Natural Science Foundation of ChinaProject(20110172110003)supported by ResearchFund for the Program of Higher Education of China
文摘The electromigration induced microstructure evolution and damage in asymmetric Cu/Sn-58Bi/Cu solder interconnects were investigated by in-situ SEM observation, focused ion beam （FIB） microanalysis and finite element （FE） simulation. The SEM results show that the electromigration-induced local degradation of microstructures, i.e., segregation of Bi-rich phase and formation of microcracks, in the asymmetric solder interconnects is much severer than that in the symmetrical ones. FIB-SEM microanalysis reveals that the microregional heterogeneity in electrical resistance along different electron flowing paths is the key factor leading to non-uniform current distribution and the resultant electromigration damage. Theoretical analysis and FE simulation results manifest that the current crowding easily occurs at the local part with smaller resistance in an asymmetric solder interconnect. All results indicate that the asymmetric shape of the solder interconnect brings about the difference of the electrical resistance between the different microregions and further results in the severe electromigration damage.
文摘A plate of dual phase steel was produced from low carbon steel with intercritical annealing treatment. Its optically determined surface microstructure was utilized to construct three different microstructural models. To describe the ductile damage in the ferritic matrix, the Gurson-Tvergaard-Needleman model was used with the failure in the martensite phase being ignored. The numerical results obtained for the mechanism of void initiation and coalescence were compared with the experimental observations. The numerical results obtained from the randomly extruded 3D model showed a significantly better agreement with the experimental ones than those obtained from the 2D model or the uniformly extruded 3D model.
基金National Key Research and Development Program of China (No.2021YFC3100800)the National Natural Science Foundation of China (Nos.42407235 and 42271026)+1 种基金the Project of Sanya Yazhou Bay Science and Technology City (No.SCKJ-JYRC-2023-54)supported by the Hefei advanced computing center
文摘Coral reef limestone(CRL)constitutes a distinctive marine carbonate formation with complex mechanical properties.This study investigates the multiscale damage and fracture mechanisms of CRL through integrated experimental testing,digital core technology,and theoretical modelling.Two CRL types with contrasting mesostructures were characterized across three scales.Macroscopically,CRL-I and CRL-II exhibited mean compressive strengths of 8.46 and 5.17 MPa,respectively.Mesoscopically,CRL-I featured small-scale highly interconnected pores,whilst CRL-II developed larger stratified pores with diminished connectivity.Microscopically,both CRL matrices demonstrated remarkable similarity in mineral composition and mechanical properties.A novel voxel average-based digital core scaling methodology was developed to facilitate numerical simulation of cross-scale damage processes,revealing network-progressive failure in CRL-I versus directional-brittle failure in CRL-II.Furthermore,a damage statistical constitutive model based on digital core technology and mesoscopic homogenisation theory established quantitative relationships between microelement strength distribution and macroscopic mechanical behavior.These findings illuminate the fundamental mechanisms through which mesoscopic structure governs the macroscopic mechanical properties of CRL.
文摘The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in Brazil.Yet,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.
基金Project supported by the National Major Science & Technology Project of China (Grant No. 2016ZX05020-003).
文摘We present an in-depth study of the failure phenomenon of solid expandable tubular (SET) due to large expansion ratio in open holes of deep and ultra-deep wells. By examining the post-expansion SET, lots of microcracks are found on the inner surface of SET. Their morphology and parameters such as length and depth are investigated by use of metallographic microscope and scanning electron microscope (SEM). In addition, the Voronoi cell technique is adopted to characterize the multi-phase material microstructure of the SET. By using the anisotropic elastoplastic material constitutive model and macro/microscopic multi-dimensional cross-scale coupled boundary conditions, a sophisticated and multi-scale finite element model (FEM) of the SET is built successfully to simulate the material microstructure damage for different expansion ratios. The microcrack initiation and growth is simulated, and the structural integrity of the SET is discussed. It is concluded that this multi-scale finite element modeling method could effectively predict the elastoplastic deformation and the microscopic damage initiation and evolution of the SET. It is of great significance as a theoretical analysis tool to optimize the selection of appropriate tubular materials and it could be also used to substantially reduce costly failures of expandable tubulars in the field. This numerical analysis is not only beneficial for understanding the damage process of tubular materials but also effectively guides the engineering application of the SET technology.
文摘The DDR(DNA damage response)is an essential cellular mechanism that detects and repairs DNA lesions to maintain genomic stability.Dysregulation of DDR pathways is frequently observed in human tumors,leading to increased genomic instability and promoting tumor progression.Consequently,targeting DDR mechanisms has emerged as a promising therapeutic strategy in oncology.This review provides an overview of the major DDR pathways,highlighting the roles of key proteins involved in various DDR processes.A detailed understanding of these molecular mechanisms has paved the way for the development of targeted antitumor agents,including inhibitors of PARP1,ATM,ATR,CHK1,CHK2,DNA-PK,and WEE1.Additionally,the significant challenges in the development of DDR inhibitors are examined,including tumor microenvironment heterogeneity,resistance mechanisms,issues with selectivity and toxicity,and the complexities associated with clinical trial design.Finally,future directions and emerging strategies to improve DDR-targeted therapies are discussed.These strategies include biomarker-driven precision medicine,novel combination therapies,advanced drug delivery systems,and the potential application of artificial intelligence to optimize treatment outcomes.
文摘To verify the wear resistance and erosion resistance of Ti-doped Ta_(2)O_(5)coating(TTO),a series of TTOs were prepared by magnetron sputtering technology by controlling the power of the Ti target.The change of growth structure,microstructure,and tribological properties of TTOs with Ti target power was studied.After the erosion test,the variation of erosion damage behavior of TTOs with mechanical properties under different erosion conditions was further studied.The results show that the TTOs eliminate the roughness,voids,and defects in the material due to the mobility of the adsorbed atoms during the growth process,and a flat and dense smooth surface is obtained.Tribological tests show that the TTOs are mainly characterized by plastic deformation and microcrack wear mechanism.Higher Ti target power can improve the wear resistance of TTOs.Erosion test results reveal that the impact crater,furrow,micro-cutting,brittle spalling,and crack formation are the main wear mechanisms of the TTOs samples under erosion conditions.
