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Insights into the DNA damage response and tumor drug resistance
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作者 Xiaolu Ma Zina Cheng Caixia Guo 《Cancer Biology & Medicine》 2025年第3期197-204,共8页
Overview of the DNA damage response(DDR)in tumor cells.DDR is a highly coordinated signaling network that repairs DNA damage caused by intrinsic cellular processes and extrinsic insults,thereby preventing genome insta... Overview of the DNA damage response(DDR)in tumor cells.DDR is a highly coordinated signaling network that repairs DNA damage caused by intrinsic cellular processes and extrinsic insults,thereby preventing genome instability.Depending on the type of damage,distinct DNA damage repair and DNA damage tolerance(DDT)pathways are involved and coordinately regulated. 展开更多
关键词 genome instabilitydepending repairs dna damage signaling network DNA repair DNA damage response tumor drug resistance DNA damage tolerance dna damage
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Creep constitutive model for damaged soft rock based on fractional-order nonlinear theory 被引量:1
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作者 BAO Min ZHOU Zihan +1 位作者 CHEN Zhonghui ZHANG Lingfei 《Journal of Mountain Science》 2025年第6期2276-2290,共15页
Investigating the combined effects of mining damage and creep damage on slope stability is crucial,as it can comprehensively reveal the non-linear deformation characteristics of rock under their joint influence.This s... Investigating the combined effects of mining damage and creep damage on slope stability is crucial,as it can comprehensively reveal the non-linear deformation characteristics of rock under their joint influence.This study develops a fractional-order nonlinear creep constitutive model that incorporates the double damage effect and implements a non-linear creep subroutine for soft rock using the threedimensional finite difference method on the FLAC3D platform.Comparative analysis of the theoretical,numerical,and experimental results reveals that the fractional-order constitutive model,which incorporates the double damage effect,accurately reflects the distinct deformation stages of green mudstone during creep failure and effectively captures the non-linear deformation in the accelerated creep phase.The numerical results show a fitting accuracy exceeding 97%with the creep test curves,significantly outperforming the 61%accuracy of traditional creep models. 展开更多
关键词 Mining damage Creep damage FRACTIONAL-ORDER Constitutive model Secondary development
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Adsorption damage mechanism and control of fracturing fluid thickener in deep coal rock
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作者 YOU Lijun QIAN Rui +1 位作者 KANG Yili WANG Yijun 《Petroleum Exploration and Development》 2025年第1期208-218,共11页
Static adsorption and dynamic damage experiments were carried out on typical 8#deep coal rock of the Carboniferous Benxi Formation in the Ordos Basin,NW China,to evaluate the adsorption capacity of hydroxypropyl guar ... Static adsorption and dynamic damage experiments were carried out on typical 8#deep coal rock of the Carboniferous Benxi Formation in the Ordos Basin,NW China,to evaluate the adsorption capacity of hydroxypropyl guar gum and polyacrylamide as fracturing fluid thickeners on deep coal rock surface and the permeability damage caused by adsorption.The adsorption morphology of the thickener was quantitatively characterized by atomic force microscopy,and the main controlling factors of the thickener adsorption were analyzed.Meanwhile,the adsorption mechanism of the thickener was revealed by Zeta potential,Fourier infrared spectroscopy and X-ray photoelectron spectroscopy.The results show that the adsorption capacity of hydroxypropyl guar gum on deep coal surface is 3.86 mg/g,and the permeability of coal rock after adsorption decreases by 35.24%–37.01%.The adsorption capacity of polyacrylamide is 3.29 mg/g,and the permeability of coal rock after adsorption decreases by 14.31%–21.93%.The thickness of the thickener adsorption layer is positively correlated with the mass fraction of thickener and negatively correlated with temperature,and a decrease in pH will reduce the thickness of the hydroxypropyl guar gum adsorption layer and make the distribution frequency of the thickness of polyacrylamide adsorption layer more concentrated.Functional group condensation and intermolecular force are chemical and physical forces for adsorbing fracturing fluid thickener in deep coal rock.Optimization of thickener mass fraction,chemical modification of thickener molecular,oxidative thermal degradation of polymer and addition of desorption agent can reduce the potential damages on micro-nano pores and cracks in coal rock. 展开更多
关键词 deep coal rock gas fracturing fluid THICKENER adsorption morphology adsorption mechanism control factor permeability damage damage prevention
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Progressive fatigue damage modelling and life prediction of 3D four-directional braided composite I-beam under four-point flexure spectrum loading
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作者 Dong LI Junjiang XIONG 《Chinese Journal of Aeronautics》 2025年第3期65-84,共20页
This paper aims to experimentally and numerically probe fatigue behaviours and lifetimes of 3D4D(three-dimensional four-directional)braided composite I-beam under four-point flexure spectrum loading.New fatigue damage... This paper aims to experimentally and numerically probe fatigue behaviours and lifetimes of 3D4D(three-dimensional four-directional)braided composite I-beam under four-point flexure spectrum loading.New fatigue damage models of fibre yarn,matrix and fibre–matrix interface are proposed,and fatigue failure criteria and PFDA(Progressive Fatigue Damage Algorithm)are thus presented for meso-scale fatigue damage modelling of 3D4D braided composite I-beam.To validate the aforementioned model and algorithm,fatigue tests are conducted on the 3D4D braided composite I-beam under four-point flexure spectrum loading,and fatigue failure mechanisms are analyzed and discussed.Novel global–local FE(Finite Element)model based on the PFDA is generated for modelling progressive fatigue failure process and predicting fatigue life of 3D4D braided composite I-beam under four-point flexure spectrum loading.Good agreement has been achieved between experimental results and predictions,demonstrating the effective usage of new model.It is shown that matrix cracking and interfacial debonding initially initiates on top surface of top flange of I-beam,and then gradually propagates from the side surface of top flange to the intermediate web along the braiding angle,and considerable fiber breakage finally causes final fatigue failure of I-beam. 展开更多
关键词 Three-dimensional four-directional Braided composite I-BEAM Four-point flexure Fatigue life prediction Progressive fatigue damage Fatigue damage Finite element method
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A rock damage model considering shear failure by modified logistic growth theory
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作者 Kai Chen Roberto Cudmani Andres Peña 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第3期1321-1355,共35页
Localized rock failures,like cracks or shear bands,demand specific attention in modeling for solids and structures.This is due to the uncertainty of conventional continuum-based mechanical models when localized inelas... Localized rock failures,like cracks or shear bands,demand specific attention in modeling for solids and structures.This is due to the uncertainty of conventional continuum-based mechanical models when localized inelastic deformation has emerged.In such scenarios,as macroscopic inelastic reactions are primarily influenced by deformation and microstructural alterations within the localized area,internal variables that signify these microstructural changes should be established within this zone.Thus,localized deformation characteristics of rocks are studied here by the preset angle shear experiment.A method based on shear displacement and shear stress differences is proposed to identify the compaction,yielding,and residual points for enhancing the model's effectiveness and minimizing subjective influences.Next,a mechanical model for the localized shear band is depicted as an elasto-plastic model outlining the stress-displacement relation across both sides of the shear band.Incorporating damage theory and an elasto-plastic model,a proposed damage model is introduced to replicate shear stressdisplacement responses and localized damage evolution in intact rocks experiencing shear failure.Subsequently,a novel nonlinear mathematical model based on modified logistic growth theory is proposed for depicting the shear band's damage evolution pattern.Thereafter,an innovative damage model is proposed to effectively encompass diverse rock material behaviors,including elasticity,plasticity,and softening behaviors.Ultimately,the effects of the preset angles,temperature,normal stresses and the residual shear strength are carefully discussed.This discovery enhances rock research in the proposed damage model,particularly regarding shear failure mode. 展开更多
关键词 damage model Shear failure LOCALIZATION Shear band Modified growth theory damage evolution
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Multi-scale damage and fracture analysis and statistical damage constitutive model of shallow coral reef limestone based on digital core
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作者 Yingwei Zhu Xinping Li +4 位作者 Zhengrong Zhou Dengxing Qu Fei Meng Shaohua Hu Wenjie Li 《International Journal of Mining Science and Technology》 2025年第11期1849-1869,共21页
Coral reef limestone(CRL)constitutes a distinctive marine carbonate formation with complex mechanical properties.This study investigates the multiscale damage and fracture mechanisms of CRL through integrated experime... Coral reef limestone(CRL)constitutes a distinctive marine carbonate formation with complex mechanical properties.This study investigates the multiscale damage and fracture mechanisms of CRL through integrated experimental testing,digital core technology,and theoretical modelling.Two CRL types with contrasting mesostructures were characterized across three scales.Macroscopically,CRL-I and CRL-II exhibited mean compressive strengths of 8.46 and 5.17 MPa,respectively.Mesoscopically,CRL-I featured small-scale highly interconnected pores,whilst CRL-II developed larger stratified pores with diminished connectivity.Microscopically,both CRL matrices demonstrated remarkable similarity in mineral composition and mechanical properties.A novel voxel average-based digital core scaling methodology was developed to facilitate numerical simulation of cross-scale damage processes,revealing network-progressive failure in CRL-I versus directional-brittle failure in CRL-II.Furthermore,a damage statistical constitutive model based on digital core technology and mesoscopic homogenisation theory established quantitative relationships between microelement strength distribution and macroscopic mechanical behavior.These findings illuminate the fundamental mechanisms through which mesoscopic structure governs the macroscopic mechanical properties of CRL. 展开更多
关键词 Coral reef limestone Multi-scale mechanics Digital core Pore structure Representative volume element damage and fracture damage statistical constitutive model
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Prediction Model of Capacity Degradation in Lithium-Ion Batteries Based on Fatigue Damage Theory and Electrochemical Impedance Spectroscopy
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作者 Haibin Song Haimei Xie +2 位作者 Zilong Zhang Qian Zhang Yilan Kang 《Acta Mechanica Solida Sinica》 2025年第3期517-525,共9页
The trade-off between mechanistic interpretability,operational convenience,and predictive accuracy is challenging for predicting the lifetime of lithium-ion batteries.To resolve this contradiction,we propose a damage ... The trade-off between mechanistic interpretability,operational convenience,and predictive accuracy is challenging for predicting the lifetime of lithium-ion batteries.To resolve this contradiction,we propose a damage model based on fatigue damage theory and electrochemical impedance spectroscopy.The causal relationship of“fatigue damage→resistance increase→capacity fading”is revealed to describe the underlying mechanism.Charge transfer resistance is chosen as the variable to ensure the convenience of data acquisition.To verify the accuracy of the model,the electrochemical impedance spectrum and capacity of a graphene-coated silicon electrode at two charging rates are collected and analyzed.50% and 75% of the measured data are utilized as inputs to compare the prediction capabilities of the proposed damage model and the existing empirical model.The particle filter algorithm is adopted to train the parameters of both models.The maximum prediction error of the damage model is less than 3%,showing better prediction accuracy and medium-term prediction stability than the empirical model.Our work demonstrates that the proposed damage model is an effective way to resolve contradictions in lifetime prediction. 展开更多
关键词 Cycle capacity prediction damage model Fatigue damage theory Degradation mechanism Electrochemical impedance spectroscopy Particle filter
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Damage mechanism analysis of polymer gel to petroleum reservoirs and development of new protective methods based on NMR technique
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作者 Dao-Yi Zhu Jiong Zhang +4 位作者 Tao Zhang Ying-Qi Gao Si Guo Yong-Liang Yang Jia-Mai Lu 《Petroleum Science》 2025年第3期1225-1233,共9页
Polymer gels are widely used in water control and enhanced oil recovery in oil fields.However,the damage mechanism of polymer gels to layers with remaining oil and not requiring plugging and corresponding protective m... Polymer gels are widely used in water control and enhanced oil recovery in oil fields.However,the damage mechanism of polymer gels to layers with remaining oil and not requiring plugging and corresponding protective measures are unclear.In this paper,we investigated polymer gels'damage and protection performance through static gel-breaking experiments and dynamic plugging and oil recovery evaluations on rock cores.Moreover,nuclear magnetic resonance(NMR)technology was combined to analyze the damage performance of polymer gels on cores from the pore scale.In addition,a protective technique based on gel breakers for layers with remaining oil and not requiring plugging was proposed.Results showed that when polymer gels were injected into heterogeneous cores,they plugged high-permeability layers while also penetrating low-permeability layers.When the damage to the low-permeability layers was not alleviated,the conformance and oil displacement efficiency were significantly reduced.When the concentration of ammonium persulfate was 2%–5%,the gel-breaking time was shortest and the residue was very minimal.Therefore,ammonium persulfate could be used as a gel breaker and reservoir protective material.Furthermore,after injecting ammonium persulfate into heterogeneous reservoir cores,the gel damage on the face of low-permeability layers was relieved.Consequently,the improvement in sweep efficiency was achieved,showing the re-activation of the remaining oil in medium-low permeability layers.Therefore,the low-permeability layer protection process and core experiment study based on gel-breaking agents proposed in this study were suggested to provide a new technique for the field application of conformance modification agents,aiming to achieve higher recovery degrees. 展开更多
关键词 NMR technique Polymer gel Production layer damage damage production Gel-breaking
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Time-varying damage distribution of composite structures for a certain type of aircraft
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作者 Jinxin DENG Ziqian AN +1 位作者 Peijie YUE Xiaoquan CHENG 《Chinese Journal of Aeronautics》 2025年第3期386-402,共17页
The damage distribution of the same type of aircraft in similar service environments should be similar. Based on this assumption, to perform the maintenance and repair of aircraft composite structures, the damage of c... The damage distribution of the same type of aircraft in similar service environments should be similar. Based on this assumption, to perform the maintenance and repair of aircraft composite structures, the damage of composite structures in a certain type of aircraft were investigated. The time-varying damage distribution model was established and verified based on the damage of a 16-aircraft fleet. The results show that the quantitative proportions of structural damage are 74% for skin delamination, 22% for stringer delamination and 3% for stringer-skin interface debonding. The amount of structural damages increases linearly with service time while the proportion of different damages does not change. As the service time increases, the geometric parameter distribution of damage for the same type of aircraft gradually converges, which can be approximated using the same function. There are certain differences in the proportion and geometric parameter distribution of damages among different components and locations, and the differences do not change over time. 展开更多
关键词 AIRCRAFT Composite structures Structural damage damage dis tribution Geonetric parameters
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Macro-micro damage and energy release rates of fractured sandstone subjected to dry-wet cycles
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作者 Runqiu Wang Guilin Wang +2 位作者 Liang Zhang Fan Sun Boyi Li 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第6期3563-3576,共14页
The deterioration of rock mass in the Three Gorges reservoir area results from the coupled damage effects of macro-micro cracks and dry-wet cycles,and the coupled damage progression can be characterized by energy rele... The deterioration of rock mass in the Three Gorges reservoir area results from the coupled damage effects of macro-micro cracks and dry-wet cycles,and the coupled damage progression can be characterized by energy release rate.In this study,a series of dry-wet cycle uniaxial compression tests was conducted on fractured sandstone,and a method was developed for calculating macro-micro damage(D_(R))and energy release rates(Y_(R))of fractured sandstone subjected to dry-wet cycles by considering energy release rate,dry-wet damage and macro-micro damage.Therewith,the damage mechanisms and complex microcrack propagation patterns of rocks were investigated.Research indicates that sandstone degradation after a limited cycle count primarily exhibits exsolution of internal fillers,progressing to grain skeleton alteration and erosion with increased cycles.Compared with conventional methods,the D_(R) and Y_(R) methodologies exhibit heightened sensitivity to microcrack closure during compaction and abrupt energy release at the point of failure.Based on D_(R) and Y_(R),the failure process of fractured sandstone can be classified into six stages:stress adjustment(I),microcracks equal closure(II),nonlinear slow closure(III),low-speed extension(IV),rapid extension(V),and macroscopic main fracture emergence(VI).The abrupt change in damage energy release rate during stage V may serve as a reliable precursor for inducing failure.The stage-based classification may enhance traditional methods by tracking damage progression and accurately identifying rock failure precursors.The findings are expected to provide a scientific basis for understanding damage mechanisms and enabling early warning of reservoir-bank slope failure. 展开更多
关键词 Dry-wet cycle Energy evolution Coupled damage damage energy release rate Fractured sandstone
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Damage evolution mechanism and low-damage grinding technology of silicon carbide ceramics
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作者 Chen Li Kechong Wang +5 位作者 Oleg Zakharov Hailong Cui Mingtao Wu Tianchen Zhao Yongda Yan Yanquan Geng 《International Journal of Extreme Manufacturing》 2025年第2期551-586,共36页
Silicon carbide(SiC)ceramics are extensively utilized in aerospace,national defense,and petrochemical industries due to their superior physical and chemical properties.The processing of bulk SiC ceramics necessitates ... Silicon carbide(SiC)ceramics are extensively utilized in aerospace,national defense,and petrochemical industries due to their superior physical and chemical properties.The processing of bulk SiC ceramics necessitates precise and efficient grinding techniques to produce components with satisfactory functionality.However,the inherent high hardness and brittleness of SiC ceramics present significant challenges during grinding,leading to severe brittle fracture and tool wear that compromise both surface integrity and production efficiency.Although ductile-regime grinding of SiC ceramics can be achieved by enhancing machine tool accuracy and stiffness while optimizing wheel performance alongside appropriate selection of process parameters,a comprehensive summary of the mechanisms underlying damage evolution during grinding is lacking,and a mature grinding process for SiC ceramics has yet to be developed.To bridge this gap,the sintering technologies,mechanical properties,and microstructures of SiC ceramics were briefly covered.The grinding-induced damage mechanism and low-damage grinding technologies of SiC ceramics were summarized.The fundamental science underlying the ductile deformation and removal mechanisms of brittle solids was emphasized.Additionally,attention was directed towards the critical role of hybrid energy field grinding in minimizing brittle damages and promoting removal efficiency.This review not only elucidates the intrinsic interactions between the work material and abrasives,but also offers valuable insights for optimizing the grinding processes of brittle solids. 展开更多
关键词 GRINDING damage evolution low damage high surface integrity silicon carbide ceramics
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Damage effectiveness characterization model of laser weapon systems under the impact of spatial position and atmospheric condition
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作者 LIU Wei ZHANG Lin +3 位作者 YUN Tao MENG Xianliang ZHANG Bo SONG Yafei 《Journal of Systems Engineering and Electronics》 2025年第5期1281-1295,共15页
The emergence of laser technology has led to the gradual integration of laser weapon system(LaWS)into military scene,particularly in the field of anti-unmanned aerial vehicle(UAV),showcasing significant potential.Howe... The emergence of laser technology has led to the gradual integration of laser weapon system(LaWS)into military scene,particularly in the field of anti-unmanned aerial vehicle(UAV),showcasing significant potential.However,A current limitation lies in the absence of a comprehensive quantitative approach to assess the capabilities of LaWS.To address this issue,a damage effectiveness characterization model for LaWS is established,taking into account the properties of laser transmission through the atmosphere and the thermal damage effects.By employing this model,key parameters pertaining to the effectiveness of laser damage are determined.The impact of various spatial positions and atmospheric conditions on the damage effectiveness of LaWS have been examined,employing simulation experiments with diverse parameters.The conclusions indicate that the damage effectiveness of LaWS is contingent upon the spatial position of the target,resulting in a diminished effectiveness to damage on distant,low-altitude targets.Additionally,the damage effectiveness of LaWS is heavily reliant on the atmospheric condition,particularly in complex settings such as midday and low visibility conditions,where the damage effectiveness is substantially reduced.This paper provides an accurate and effective calculation method for the rapid decisionmaking of the operators. 展开更多
关键词 laser weapon system damage effectiveness atmospheric transmission thermal damage anti-unmanned aerial vehicle
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Macro and micro mechanical behaviors and micro damage theory of rock at low temperature freeze-thaw cycles
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作者 XIAO Peng CHEN Youliang +1 位作者 FERNÁNDEZ-STEEGER Tomás Manuel RAFIG Azzam 《Journal of Mountain Science》 2025年第6期2227-2240,共14页
Aiming at challenges posed by rock freezethaw(FT)in cold regions rock mass engineering,it is of great significance to analyze its macro-and micromechanical properties and damage laws for the smooth progress of constru... Aiming at challenges posed by rock freezethaw(FT)in cold regions rock mass engineering,it is of great significance to analyze its macro-and micromechanical properties and damage laws for the smooth progress of construction.In this study,indoor freezethaw cycle(FTC)tests on sandstone were conducted to analyze the mass change rate,density change rate,longitudinal wave velocity change rate,microstructure change and mechanical properties of sandstone after FTC.A microscopic FT damage variable reflecting the FT damage was defined based on the changes of rock porosity before and after the FTC,enabling the derivation of the total damage variable under the coupled action of FTC and mechanical loading.A damage evolution equation and a microscopic damage constitutive model for rock under coupled FTC and confining pressure were established by using Lemaitre’s strain equivalence principle,the theory of continuous damage mechanics,and the assumption that the failure of rock micro-units follows the SMP criterion.The rationality and accuracy of the model were verified using triaxial compression test data for FT-damaged rock.The results show that both macroand micro-mechanical properties of sandstone are degraded under the action of FTC,resulting in significant damage.The developed microscopic damage constitutive model can reflect the stress-strain characteristics of the whole process of FT rock triaxial compression,with excellent agreement observed between experimental and theoretical curves.This validates the reliability of the model and the methodology for determining its parameters.Additionally,defining the microscopic FT damage variable based on rock porosity changes is demonstrated to be a feasible and highly accurate approach to reflect rock FT damage degree.This model expands the damage model for rock under the coupling effect of FTC and confining pressure,further illuminating the damage mechanism and failure law in such environments.The findings provide references for the construction of rock mass engineering in cold regions. 展开更多
关键词 Freeze-thaw cycles Mechanical properties Microscopic freeze-thaw damage variable damage evolution Constitutive model
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Experimental study on damage law of coal seam under hydraulic fracturing and blast load
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作者 Haiyan Chen Hongzhao Wei +3 位作者 Jinhua Chen Wenxue Sun Huiyong Niu Chunmiao Yuan 《International Journal of Coal Science & Technology》 2025年第3期121-136,共16页
Compared with blast mining only,blast mining after on-site hydraulic fracturing can make the mining easier and obtain better mining outcomes.To explore the effects of hydraulic fracturing on the blasting damages in co... Compared with blast mining only,blast mining after on-site hydraulic fracturing can make the mining easier and obtain better mining outcomes.To explore the effects of hydraulic fracturing on the blasting damages in coal seam,blasting experiments were carried out under biaxial confining pressure using the synthetic coal briquettes.The coal briquettes with the same mechanical properties as coal seam were prepared and the mica sheets with different radi and thicknesses were added to simulate the internal hydraulic fractures of different radi and openings.The internal damage distributions and stress attenuations of the coal briquette specimens with different hydraulic fracture radi and openings after the blasting were then measured using a rock ultrasonic tester and a static-dynamic strainmeter.Based on the rock blasting theory,the effects of hydraulic fractures with different radi and openings on the blast fracture propagation and coal seam damage were analyzed.The following conclusions are drawn:(1)The increases in hydraulic fracture radius mainly enhance the damages in the vertical direction to the hydraulic fracture,and can increase the vertical range of the severely damaged area by 20-25 cm.The increases in the hydraulic fracture opening mainly cause more severe damages along the direction of the hydraulic fracture and increase the horizontal range of the severely damaged area by 30 cm.(2)The area of the severely damaged area caused by blasting increases by 550 cm?as the hydraulic fracture radius increased from 5 to 15 cm.As the hydraulic fracture opening increased from 2 to 10 mm,and the area of the severely damaged area caused by blasting increases by 650 cm?.Therefore,the hydraulic fracture opening has greater impacts on the severely damaged area.(3)The increase in the hydraulic fracture length reduces the compression phase attenuation of the blast stress in the radial direction.Both the increases of the hydraulic fracture length and opening increase the absolute value of the tensile phase in the radial direction.(4)Increasing the hydraulic fracture radius and opening can greatly promote the development of blast fractures and enhance the damages to coal seam.Therefore,the coal seam mining effect can be improved by increasing the radi or openings of hydraulic fractures to adjust the main action direction of blast fracture. 展开更多
关键词 Hydraulic fracture Fracture propagation law Blasting damage Strain test Ultrasonic damage detection
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Advances in the mechanism of small nucleolar RNA and its role in DNA damage response
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作者 Li-Ping Shen Wen-Cheng Zhang +3 位作者 Jia-Rong Deng Zhen-Hua Qi Zhong-Wu Lin Zhi-Dong Wang 《Military Medical Research》 2025年第6期903-937,共35页
Small nucleolar RNAs(snoRNAs)were previously regarded as a class of functionally conserved housekeeping genes,primarily involved in the regulation of ribosome biogenesis by ribosomal RNA(rRNA)modification.However,some... Small nucleolar RNAs(snoRNAs)were previously regarded as a class of functionally conserved housekeeping genes,primarily involved in the regulation of ribosome biogenesis by ribosomal RNA(rRNA)modification.However,some of them are involved in several biological processes via complex molecular mechanisms.DNA damage response(DDR)is a conserved mechanism for maintaining genomic stability to prevent the occurrence of various human diseases.It has recently been revealed that snoRNAs are involved in DDR at multiple levels,indicating their relevant theoretical and clinical significance in this field.The present review systematically addresses four main points,including the biosynthesis and classification of snoRNAs,the mechanisms through which snoRNAs regulate target molecules,snoRNAs in the process of DDR,and the significance of snoRNA in disease diagnosis and treatment.It focuses on the potential functions of snoRNAs in DDR to help in the discovery of the roles of snoRNAs in maintaining genome stability and pathological processes. 展开更多
关键词 Small nucleolar RNAs(snoRNAs) DNA damage response(DDR) Oxidative stress Cell cycle checkpoints DNA damage repair Cell death
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A novel shear damage model of the shear deformation and failure process of gas hydrate-bearing sediments
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作者 Hui WANG Bo ZHOU 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 2025年第2期151-165,共15页
A novel shear damage model based on homogenization theory and a modified Mohr-Coulomb criterion is proposed to predict the full deformation process of gas hydrate-bearing sediments(GHBSs)during shearing by analyzing m... A novel shear damage model based on homogenization theory and a modified Mohr-Coulomb criterion is proposed to predict the full deformation process of gas hydrate-bearing sediments(GHBSs)during shearing by analyzing micro-mechanisms of shear deformation and failure characteristics.Then,the physical significance of the model's parameters is explored.Finally,the damage evolution and shear stress partition inside GHBSs during the shearing process are analyzed in detail.The results show that model parameters have clear physical meaning,and the shear damage model is capable of reflecting the nonlinear deformation and strain softening characteristics of GHBSs due to its ability to better describe the damage evolution and shear stress partition mechanisms inside GHBSs during the shearing process.Comparisons of experimental and theoretical results show that the global performance of the novel shear damage model is satisfactory.The model is expected to be widely adopted to analyze submarine landslide instability due to hydrate dissociation. 展开更多
关键词 Gas hydrate-bearing sediments(GHBSs) Shear damage model Homogenization theory Modified Mohr-Coulomb(MC)criterion damage evolution
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Damage indices for RC columns under three-dimensional excitation
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作者 Zhang Haoyu Mao Chenxi Zhou Wei 《Earthquake Engineering and Engineering Vibration》 2025年第2期357-380,共24页
Damage indices are effective in quantifying structural seismic damage.Numerous response-based damage indices have been developed and validated through the hysteretic response of various experimental specimens.However,... Damage indices are effective in quantifying structural seismic damage.Numerous response-based damage indices have been developed and validated through the hysteretic response of various experimental specimens.However,the accuracy of these indices for evaluating damage of RC columns is challenged by fluctuating axial load and irregular horizontal loading paths from 3-D earthquake excitations.This study introduces D_(iem),a material-based damage model for RC columns under random bidirectional loads and variable axial forces.Section damage indices of the plastic hinge are calculated by integrating the damage indices of concrete and steel fiber elements,considering their distance to the centroid axis.The P-Δeffect index is defined,and the component failure index is calculated using a combination of these indices.A hysteretic simulation and D_(iem)damage analysis program for cantilever RC columns is developed using Fortran.Three RC columns tested under bidirectional hysteretic loading are simulated to calibrate the program.Parameter analysis of 1,638 RC columns is conducted to verify D_(iem)’s applicability.The results demonstrated that D_(iem)’s failure assessment aligns with the 80%residual criterion.D_(iem)analysis of a real seismic damaged RC column shows satisfactory agreement with post-earthquake damage assessment and illustrates significant damage differences between columns with and without axial load fluctuation. 展开更多
关键词 damage indices three-dimensional seismic loading material damage indices integration of element materials
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Temperature-effect incorporated damage assessment methodology for beam-slab composite structures subjected to long-duration blast loads
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作者 Wei Liu Wei Wang +6 位作者 Zhenyu Lu Baoding Li Bin Zhang Bo Gao Xucai Wang Gang Peng Benjun Shi 《Defence Technology(防务技术)》 2025年第11期126-150,共25页
Aiming at addressing the issues of unclear dynamic response mechanisms and insufficient quantification of temperature coupling effects in building structures under long-duration blast loads,this study investigates typ... Aiming at addressing the issues of unclear dynamic response mechanisms and insufficient quantification of temperature coupling effects in building structures under long-duration blast loads,this study investigates typical composite beam-slab structures through integrated blast shock tube experiments and multiscale numerical simulations using Voronoi-coupled Finite-Discrete Element Method(VoroFDEM).The research systematically reveals the dynamic response mechanisms and damage evolution patterns of composite beam-slab structures subjected to prolonged blast loading.An environmenttemperature-coupled P-I curve damage assessment system is established,and a rapid evaluation method based on image crack characteristics is proposed,achieving innovative transition from traditional mechanical indicators to intelligent recognition paradigms.Results demonstrate that composite beam-slab structures exhibit three-phase failure modes:elastic vibration,plastic hinge formation,and global collapse.Numerical simulations identify the brittle-to-ductile transition temperature threshold at-10℃,and establish a temperature-dependent piecewise function-based P-I curve prediction model,whose overpressure asymptote displays nonlinear temperature sensitivity within-50-30℃.A novel dual-mode evaluation methodology integrating Voro-FDEM numerical simulations with image-based damage feature recognition is developed,enabling quantitative mapping between crack area and destruction levels.These findings provide theoretical foundations and technical pathways for rapid blast damage assessment and protective engineering design. 展开更多
关键词 Long-duration blast loads Beam-slab composite structures damage assessment methodology Pressure-impulse(P-I)damage criterion
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A Damage Control Model for Reinforced Concrete Pier Columns Based on Pre-Damage Tests under Cyclic Reverse Loading
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作者 Zhao-Jun Zhang Jing-Shui Zhen +3 位作者 Bo-Cheng Li De-Cheng Cai Yang-Yang Du Wen-Wei Wang 《Structural Durability & Health Monitoring》 2025年第2期327-346,共20页
To mitigate the challenges in managing the damage level of reinforced concrete(RC)pier columns subjected to cyclic reverse loading,this study conducted a series of cyclic reverse tests on RC pier columns.By analyzing ... To mitigate the challenges in managing the damage level of reinforced concrete(RC)pier columns subjected to cyclic reverse loading,this study conducted a series of cyclic reverse tests on RC pier columns.By analyzing the outcomes of destructive testing on various specimens and fine-tuning the results with the aid of the IMK(Ibarra Medina Krawinkler)recovery model,the energy dissipation capacity coefficient of the pier columns were able to be determined.Furthermore,utilizing the calibrated damage model parameters,the damage index for each specimen were calculated.Based on the obtained damage levels,three distinct pre-damage conditions were designed for the pier columns:minor damage,moderate damage,and severe damage.The study then predicted the variations in hysteresis curves and damage indices under cyclic loading conditions.The experimental findings reveal that the displacement at the top of the pier columns can serve as a reliable indicator for controlling the damage level of pier columns post-loading.Moreover,the calibrated damage index model exhibits proficiency in accurately predicting the damage level of RC pier columns under cyclic loading. 展开更多
关键词 Reinforced concrete pier cyclic reverse load pre-damage damage index displacement control
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Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations:A Review 被引量:3
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作者 Chao Zhang Shang-Xi Lai Hua-Ping Wang 《Structural Durability & Health Monitoring》 EI 2025年第1期25-54,共30页
Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters accordi... Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientific basis for structural damage identification and dynamic model modification.In view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and briefly describes how to identify structural damages based on the derived modal parameters.The paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),briefly describes damage identification methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artificial intelligence(AI)methods in the direction of modal parameter recognition and damage identification is further discussed.Based on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identification methods are given to provide scientific references for the optimized design and functional upgrading of SHM systems. 展开更多
关键词 Structural health monitoring data information modal parameters damage identification AI method
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