With the rapid growth of scientific paper data,intelligent fine-grained document classification techniques can significantly benefit paper retrieval and recommendation.Previous works on paper classification focused on...With the rapid growth of scientific paper data,intelligent fine-grained document classification techniques can significantly benefit paper retrieval and recommendation.Previous works on paper classification focused on texts and were coarse-grained.The high sample similarity within subdivided fields makes fine-grained classification more challenging.Given the implicit semantic relationship between abstracts and figures in academic papers,current multimodal methods designed to process explicitly related textual and visual data are inadequate for addressing the fine-grained multimodal paper classification task.Additionally,discrepancies in data distribution and dataset limitations frequently result in overfitting when pretrained models are transferred to paper classification tasks.In this work,we propose a multimodal regularization ensemble network for fine-grained paper classification.Our model focuses on the differentiation of intra-modality feature representations and the enhancement of inter-modality related information for the task.Comparative analysis with baseline methods highlights the efficiency of our proposed model.Finally,we developed a paper classification system based on our model that is capable of classifying,managing,and recommending academic papers.展开更多
目的:探讨TSLC1和DAL-1/4.1B两种蛋白在胰腺癌中的表达和临床病理意义.方法:采用免疫组织化学S-P法检测42例胰腺癌组织、11例胰腺炎组织和9例正常胰腺组织中TSLC1和DAL-1/4.1B两种蛋白的表达.结果:TSLC1、DAL-1/4.1B蛋白在胰腺癌组织中...目的:探讨TSLC1和DAL-1/4.1B两种蛋白在胰腺癌中的表达和临床病理意义.方法:采用免疫组织化学S-P法检测42例胰腺癌组织、11例胰腺炎组织和9例正常胰腺组织中TSLC1和DAL-1/4.1B两种蛋白的表达.结果:TSLC1、DAL-1/4.1B蛋白在胰腺癌组织中的阳性表达率均明显低于在正常胰腺组织和胰腺炎组织中的表达(30.95%vs77.78%,81.82%;28.57% vs 66.67%,81.82%,P<0.05或0.01).TSLC1和DAL-1/4.1B蛋白的异常表达均与胰腺癌的分化程度、淋巴结转移和TNM分期相关(P<0.05),而与患者的性别、年龄、部位和病理分型无关.在42例胰腺癌中TSLC1与DAL-1/4.1B蛋白表达呈显著正相关(rs=0.489,P<0.01).结论:胰腺癌中存在TSLC1和DAL-1/4.1B基因的失活和蛋白表达下调,二者可能通过TSLC1-DAL-1/4.1B级联反应共同参与胰腺癌的发生、发展和转移.展开更多
目的:研究肺癌肿瘤抑制物1(tumor suppressor i n lung cancer-1,TSLC1)、肺腺癌差异表达因子4.1B(differentially expressed in adenocarcinoma of the lung/4.1B,DAL-1/4.1B)和果蝇肿瘤抑制因子同源分子-3(membraneprotein palmitoyla...目的:研究肺癌肿瘤抑制物1(tumor suppressor i n lung cancer-1,TSLC1)、肺腺癌差异表达因子4.1B(differentially expressed in adenocarcinoma of the lung/4.1B,DAL-1/4.1B)和果蝇肿瘤抑制因子同源分子-3(membraneprotein palmitoylated 3,MPP3)在大肠癌中的表达及其相互关系,并探讨其临床病理意义.方法:采用免疫组织化学EnVisionTM法检测76例大肠癌和22例正常肠黏膜组织中TSLC1、DAL-1/4.1B、MPP3的表达,并结合其临床病理特征分析.结果:正常肠黏膜组织中TSLC1、DAL-1/4.1B和MPP3均呈清晰的棕黄色染色定位在上皮细胞质和/或细胞膜.TSLC1、DAL-1/4.1B和MPP3蛋白在大肠癌中的阳性表达率均明显低于其在正常肠黏膜组织中的表达(32.89%vs81.81%,27.63%vs 63.64%,35.53%vs 68.18%;P<0.05).TSLC1、DAL-1/4.1B和MPP3蛋白在大肠癌的表达缺失与肿瘤的分化程度、浸润深度、淋巴结转移和Dukes'分期密切相关(P<0.05),而与患者的性别、年龄和肿瘤大小无关.结论:大肠癌中存在TSLC1、DAL-1/4.1B和MPP3基因的表达缺失,TSLC1与DAL-1/4.1B及MPP3之间的相互作用可能是其发挥肿瘤抑制作用的主要分子机制,三者可能通过TSLC1级联反应共同参与大肠癌的发生、发展和转移.展开更多
肺癌肿瘤抑制物基因1（tumor suppressor of non—small cell lung cancer1／TSLC1）和肺腺癌差异表达因子4．1B（differentially expressed in adenocarcinoma of the lung／4．1B，DAL-1／4．1B）均是近年新发现的抑癌基因，具有潜在...肺癌肿瘤抑制物基因1（tumor suppressor of non—small cell lung cancer1／TSLC1）和肺腺癌差异表达因子4．1B（differentially expressed in adenocarcinoma of the lung／4．1B，DAL-1／4．1B）均是近年新发现的抑癌基因，具有潜在的肿瘤抑制作用。研究表明二者在多种组织中都有表达，而且在许多肿瘤中均表现为表达减低或表达缺失。肿瘤的浸润程度、转移程度和疾病预后情况与抑癌基因的表达与否密切相关，抑癌基因失活的主要可能机制之一是基因启动子发生甲基化。二者可作为新的肿瘤标志物，指导肿瘤的早期诊断及靶基因治疗。展开更多
基金supported by the BUPT innovation and entrepreneurship support program(2022-YC-S002)We also thank the National Key R&D Program of China(2022YFB3605601).
文摘With the rapid growth of scientific paper data,intelligent fine-grained document classification techniques can significantly benefit paper retrieval and recommendation.Previous works on paper classification focused on texts and were coarse-grained.The high sample similarity within subdivided fields makes fine-grained classification more challenging.Given the implicit semantic relationship between abstracts and figures in academic papers,current multimodal methods designed to process explicitly related textual and visual data are inadequate for addressing the fine-grained multimodal paper classification task.Additionally,discrepancies in data distribution and dataset limitations frequently result in overfitting when pretrained models are transferred to paper classification tasks.In this work,we propose a multimodal regularization ensemble network for fine-grained paper classification.Our model focuses on the differentiation of intra-modality feature representations and the enhancement of inter-modality related information for the task.Comparative analysis with baseline methods highlights the efficiency of our proposed model.Finally,we developed a paper classification system based on our model that is capable of classifying,managing,and recommending academic papers.
文摘目的:探讨TSLC1和DAL-1/4.1B两种蛋白在胰腺癌中的表达和临床病理意义.方法:采用免疫组织化学S-P法检测42例胰腺癌组织、11例胰腺炎组织和9例正常胰腺组织中TSLC1和DAL-1/4.1B两种蛋白的表达.结果:TSLC1、DAL-1/4.1B蛋白在胰腺癌组织中的阳性表达率均明显低于在正常胰腺组织和胰腺炎组织中的表达(30.95%vs77.78%,81.82%;28.57% vs 66.67%,81.82%,P<0.05或0.01).TSLC1和DAL-1/4.1B蛋白的异常表达均与胰腺癌的分化程度、淋巴结转移和TNM分期相关(P<0.05),而与患者的性别、年龄、部位和病理分型无关.在42例胰腺癌中TSLC1与DAL-1/4.1B蛋白表达呈显著正相关(rs=0.489,P<0.01).结论:胰腺癌中存在TSLC1和DAL-1/4.1B基因的失活和蛋白表达下调,二者可能通过TSLC1-DAL-1/4.1B级联反应共同参与胰腺癌的发生、发展和转移.
文摘目的:研究肺癌肿瘤抑制物1(tumor suppressor i n lung cancer-1,TSLC1)、肺腺癌差异表达因子4.1B(differentially expressed in adenocarcinoma of the lung/4.1B,DAL-1/4.1B)和果蝇肿瘤抑制因子同源分子-3(membraneprotein palmitoylated 3,MPP3)在大肠癌中的表达及其相互关系,并探讨其临床病理意义.方法:采用免疫组织化学EnVisionTM法检测76例大肠癌和22例正常肠黏膜组织中TSLC1、DAL-1/4.1B、MPP3的表达,并结合其临床病理特征分析.结果:正常肠黏膜组织中TSLC1、DAL-1/4.1B和MPP3均呈清晰的棕黄色染色定位在上皮细胞质和/或细胞膜.TSLC1、DAL-1/4.1B和MPP3蛋白在大肠癌中的阳性表达率均明显低于其在正常肠黏膜组织中的表达(32.89%vs81.81%,27.63%vs 63.64%,35.53%vs 68.18%;P<0.05).TSLC1、DAL-1/4.1B和MPP3蛋白在大肠癌的表达缺失与肿瘤的分化程度、浸润深度、淋巴结转移和Dukes'分期密切相关(P<0.05),而与患者的性别、年龄和肿瘤大小无关.结论:大肠癌中存在TSLC1、DAL-1/4.1B和MPP3基因的表达缺失,TSLC1与DAL-1/4.1B及MPP3之间的相互作用可能是其发挥肿瘤抑制作用的主要分子机制,三者可能通过TSLC1级联反应共同参与大肠癌的发生、发展和转移.
文摘肺癌肿瘤抑制物基因1（tumor suppressor of non—small cell lung cancer1／TSLC1）和肺腺癌差异表达因子4．1B（differentially expressed in adenocarcinoma of the lung／4．1B，DAL-1／4．1B）均是近年新发现的抑癌基因，具有潜在的肿瘤抑制作用。研究表明二者在多种组织中都有表达，而且在许多肿瘤中均表现为表达减低或表达缺失。肿瘤的浸润程度、转移程度和疾病预后情况与抑癌基因的表达与否密切相关，抑癌基因失活的主要可能机制之一是基因启动子发生甲基化。二者可作为新的肿瘤标志物，指导肿瘤的早期诊断及靶基因治疗。
