Our overall knowledge of the medicinal uses of plants suggests that natural compounds could be useful in the treatment of cutaneous fungal infections in tropical regions. Furthermore, the possibilities of treatment us...Our overall knowledge of the medicinal uses of plants suggests that natural compounds could be useful in the treatment of cutaneous fungal infections in tropical regions. Furthermore, the possibilities of treatment using plant extracts may be even broader than is already known when one considers plants that have not been extensively studied in this context, such as the regional species Phoenix dactylifera and Ziziphus spina-christi. This study compared the antimicrobial activity of Phoenix dactylifera and Ziziphus spina-christi extracts in terms of their biochemical and molecular effects on Candida albicans (ATCC CA 10231). These effects included altered levels of intracellular sterols, changes in the permeability of the cell membrane, and changes in the TEF1: QRTTEF1, CaERG1: ERG1, CdERG12: CdERG1, and ERG25: ERG25 genes. Scanning electron microscopy (SEM) was used to identify morphological characteristics, and energy-dispersive X-ray spectroscopy (EDAX) analyses were conducted. In treated samples, the SEM and EDAX analyses showed cell cavities and shrinkage of the cell wall, and the number of cells was reduced to only a few abnormal cells as compared with that in the untreated samples. Yttrium was detected in the cells treated with Z. spina-christi, and high levels of osmium were detected in the cells treated with P. dactylifera. Compared with control cells, cells exposed to the concentration 150 μl/ml of Z. spina-christi extract had an average sterol concentration that was nearly 3 times higher, while the concentration was 5.5 times higher for cells treated with the 150 μl/ml of P. dactylifera extract. The ethanol extracts affected the permeability of C. albicans cell membrane. Gene sequencing showed gaps and mismatches in the ERG1, ERG12, and ERG25 genes after treatment with P. dactylifera and Z. spina-christi extracts compared with that in the controls. The results were highly significant (p ≤ 0.01). We conclude that the ethanol extracts of P. dactylifera and Z. spina-christi have antimicrobial activity through several mechanisms in the yeast cell.展开更多
Objective: To investigate different types of dates and medical properties of influencing blood clotting and wound healing in an animal model. Methods: Three different cultivars of dates(Ajwa, Khalas, and Fardh) were e...Objective: To investigate different types of dates and medical properties of influencing blood clotting and wound healing in an animal model. Methods: Three different cultivars of dates(Ajwa, Khalas, and Fardh) were examined in-vivo, for blood clotting and wound healing using CD1 mice of both sexes. Study of toxicity to animals was performed accordingly prior to further investigations. The ethanolic extracts were given orally to animals as a constituent in their daily water. Blood samples were obtained from the mice inferior vena cava to carry out the prothrombin time(PT) assay using the manual method and confirmed using a semi-automated machine. The bleeding time(BT) assay was performed using the cutting technique. In the wound healing analysis, a small cut(5-10 mm) in the skin overlying the thigh was conducted in all mice under anesthesia. The diameter of the cut and healing status were measured on a daily basis throughout the time of the experiment using a roller. Results: Ajwa was able to elevate both PT and BT(P<0.05), significantly in a time-dependent manner followed by Khalas date(P<0.05). The results of PT and BT of Fardh date were found to be very close to those of the control group(P<0.05). Despite its activity as an anticoagulant, Khalas date showed a potential property to enhance wound healing in contrast to other dates and the control groups in this study. Conclusions: Omani Khalas date fruit has both antithrombotic as well as wound healing properties. The results open a new gate with these fruits for exploring the potential component(s) that may play an important role in antithrombotic as well as wound healing process.展开更多
Background: Dopamine has been known to facilitate male sexual function. Methods: The effect of aqueous extract (140 mg/kg) of Phoenix dactylifera date palm pollen on sexual behavior and determining of dopamine transmi...Background: Dopamine has been known to facilitate male sexual function. Methods: The effect of aqueous extract (140 mg/kg) of Phoenix dactylifera date palm pollen on sexual behavior and determining of dopamine transmission in the nucleus accumbens was studied in male rats using in vivo microdialysis. Results: Releasing of dopamine increased significantly in the nucleus accumbens when a receptive female was introduced behind a screen (p 0.001). During copulation, dopamine increased markedly in control and treated rats. Phoenix dactylifera Date Palm Pollen enhanced the orientation of males towards females by increasing mounting and ano-genital investigatory behavior. Improving of sexual behavior and dopamine release was higher in treated rats in comparison with control (p 0.001). Conclusion: These results indicate a neurochemical basis for interaction between dopaminergic agents and male sexual behavior. Therefore, Phoenix dactylifera Date Palm Pollen seems to act as a dopamine agonist and to cure male infertility. It can be used as an aphrodisiac that leads to further increases in dopamine release.展开更多
Aim of study: Ancient literature alluded to the use of a number of plants/preparations as sex enhancer. One of such botanicals is Phoenix dactylifera in which the pollen grain has been acclaimed to be used as an aphro...Aim of study: Ancient literature alluded to the use of a number of plants/preparations as sex enhancer. One of such botanicals is Phoenix dactylifera in which the pollen grain has been acclaimed to be used as an aphrodisiac. However, the validity has not been scientifically tested. Dopamine is known to facilitate male sexual function. Therefore, the present study was undertaken to evaluate the effect of aqueous extract of Phoenix dactylifera pollen on the sexual behavior of male rats and to measure of serum Estradiol and Testostrone. Also, dopamine transmission in the nucleus accumbence (NAc) was studied in male rats using in vivo microdialysis. Methods and Materials: sixty male rats were randomized into 6 groups (A-F). Group A received 0.2 ml of Normal Saline mixed with Dimethyl Sulphate (DMSO), while groups B-F were injected same volume containing 35 mg/kg, 70 mg/kg, 105 mg/kg, 140 mg/kg and 350 mg/kg of DPP extract, respectively. Sexual behavioral parameters including mounting, intromission and ejaculation frequencies and latencies were recorded in male rats one hour after injection of extract by mating with a receptive female (1:1). The male serum testosterone and estradiol concentrations were also determined. Results: All doses stimulated male sexual behavior. Extract significantly increased mount, ejaculation, intromission frequencies and ejaculation latency in comparison to controlled ones (p 0.001). Mount and intromission latencies significantly reduced (p 0.001). Maximum effect was observed in dose 140 mg/kg. This extract was found to enhance Testestrone, Estradiol and the orientation of males toward female ones by increasing mounting and ano-genital investigatory behavior. Conclusions: Data from this study identified that the aqueous extract of Phoenix dactylifera pollen grain enhanced sexual behaviour in male rats. The improved sexual appetitive behaviour in male rats may be attributed, to the alkaloids, saponins, and or flavonoids since these phytochemicals has engorgement, androgen enhancing. Also, our findings support the traditional use of this plant as acclaimed aphrodisiac and for the treatment of pre-ejaculation and impotency.展开更多
Objective:To evaluate and compare the antioxidant activity,total phenolic contents(TPCs) and in vitro antidiabetic activity of various pits extracts obtained from five Omani date cultivars.Methods:Sun-dried mature fru...Objective:To evaluate and compare the antioxidant activity,total phenolic contents(TPCs) and in vitro antidiabetic activity of various pits extracts obtained from five Omani date cultivars.Methods:Sun-dried mature fruits of five Omani date varieties,namely,Fardh,Naghal,Khalas,Khinazi and Khasab were purchased from the local market in Muscat,Oman in the month of September 2014.Four seed extracts viz.water,ethanol,methanol and acetone were prepared for each date variety and their antioxidant activities were investigated by 1,1-diphenyl-2-picrylhydrazyl,hydrogen peroxide scavenging method and reducing power assay method,respectively.In vitro antidiabetic activity of the date pit extracts was evaluated by measuring their inhibitory effect on a-glucosidase and aamylase level.TPCs were also quantified colorimetrically.Results:The results indicated that TPC of date seeds was solvent dependent.Acetone,ethanol and methanol were found to be significantly better solvents than water in extracting phenolic compounds from the date seeds.Pit extracts exhibited moderate to good in vitro antioxidant activity and increased reducing power.Among all date pit extracts,water extract exhibited significant in vitro antidiabetic activity in comparison to standard drug,acarbose.Conclusions:The present study confirms that disposed waste of Omani dates is a rich source of dietary antioxidant because of its high TPC.The pits due to their inhibitory effects on a-glucosidase and a-amylase level could be used as a monotherapy along with an appropriate diabetic diet and exercise or might be in conjunction with antidiabetic therapy to manage and prevent progression of diabetes.展开更多
Endophytic flora plays a vital role in the colonization and survival of host plants, especially in harsh environments, such as arid regions. This flora may, however, contain pathogenic species responsible for various ...Endophytic flora plays a vital role in the colonization and survival of host plants, especially in harsh environments, such as arid regions. This flora may, however, contain pathogenic species responsible for various troublesome host diseases. The present study is aimed at investigating the diversity of both cultivable and non-cultivable endophytic fungal floras in the internal tissues(roots and leaves) of Tunisian date palm trees(Phoenix dactylifera). Accordingly, 13 isolates from both root and leaf samples, exhibiting distinct colony morphology, were selected from potato dextrose agar(PDA) medium and identified by a sequence match search wherein their 18S–28S internal transcribed spacer(ITS) sequences were compared to those available in public databases. These findings revealed that the cultivable root and leaf isolates fell into two groups, namely Nectriaceae and Pleosporaceae. Additionally, total DNA from palm roots and leaves was further extracted and ITS fragments were amplified. Restriction fragment length polymorphism(RFLP) analysis of the ITS from 200 fungal clones(leaves: 100; roots: 100) using HaeIII restriction enzyme revealed 13 distinct patterns that were further sequenced and led to the identification of Alternaria, Cladosporium, Davidiella(Cladosporium teleomorph), Pythium, Curvularia, and uncharacterized fungal endophytes. Both approaches confirmed that while the roots were predominantly colonized by Fusaria(members of the Nectriaceae family), the leaves were essentially colonized by Alternaria(members of the Pleosporaceae family). Overall, the findings of the present study constitute, to the authors' knowledge, the first extensive report on the diversity of endophytic fungal flora associated with date palm trees(P. dactylifera).展开更多
Objective: To estimate the effects of the water extract of dates palm (Phoenix dactylifera) (DWE) on sperm quality parameters, testosterone level and serum antioxidants activities of New Zealand rabbits under heat str...Objective: To estimate the effects of the water extract of dates palm (Phoenix dactylifera) (DWE) on sperm quality parameters, testosterone level and serum antioxidants activities of New Zealand rabbits under heat stress. Methods: A total of 30 bucks of New Zealand White rabbits were randomly divided into three equal groups as follows: Group 1 was treated as control group and fed on balanced commercial ration. Groups 2 and 3 were treated with 10 and 20 mL of dates extract substituting water in the early morning before watering and fed on balanced commercial ration. This schedule was performed daily for 5 days/week, for an experimental period of 5 weeks. Fertility parameters such as reaction time, potential of hydrogen ion (pH), mass motility, individual progressive motility %, percentage of live sperm and abnormal sperm (%) were measured. Blood serum testosterone level, serum glutathione reduced, nitric oxide, ascorbic acid and malondialdehyde were also determined. Results: The daily oral administration of 10 mL DWE significantly increased the pH, the mass motility and individual progressive motility % compared to the control group. Although, the consumption of 20 mL DWE significantly (P<0.0001) increased the live sperm% and decreased the abnormal sperm % compared to the other two treatments. The administration of date extracts (10 and 20 mL) had significantly (P<0.0001) decreased nitric oxide and glutathione reduced levels compared to the control. On the other hand, it increased significantly the lipid peroxidation, ascorbic acid and testosterone level compared to the control. Conclusions:The aqueous extract of date palm (10-20 mL) could enhance the rabbit bucks fertility and its health performance.展开更多
Phoenix dactylifera(Fam:Arecaceae)is originated from the Mesopotamia.The date fruit,was eaten fresh,in various processed forms and dried.The fruits were used traditionally as general tonic,for the treatment of liver d...Phoenix dactylifera(Fam:Arecaceae)is originated from the Mesopotamia.The date fruit,was eaten fresh,in various processed forms and dried.The fruits were used traditionally as general tonic,for the treatment of liver diseases,memory disturbances,fever,inflammation,paralysis,loss of consciousness,nervous disorders and consumed by pregnant women before and after delivery.However,all parts of the plant were used for some purpose.Dates fruits were considered a complete diet and a very important item of food,with plenty of vitamins and minerals.It contained a wide range of secondary metabolites.It possessed many pharmacological effects included anticancer,antidiabetic,anti-inflammatory,antimicrobial,antiparasitic,antioxidant,anti-toxin,cardiovascular,hypolipidemic,gastrointestinal,immunomodullatory,neural,hepato and reno-protective,reproductive and wound healing effects.This review highlighted the chemical constituents,nutritional and pharmacological effects of Phoenix dactylifera.展开更多
The effect of NaCI and proline on somatic embryos formation and germination of date palm （Phoenix dactylifera L.） cv. Barhee was studied. Quarters of shoot tips were cultured on MS solid growth media supplied with d...The effect of NaCI and proline on somatic embryos formation and germination of date palm （Phoenix dactylifera L.） cv. Barhee was studied. Quarters of shoot tips were cultured on MS solid growth media supplied with different concentrations of salt （NaCI） （0.5%, 1%, 1.5%, 2%, 2.5% and 3%, respectively） and proline （25, 50 and 75 mg L1） either individually or in combination. Results showed that the addition of NaC1 （starting at 1%） caused a significant increase in the cylindrical embryos formation time, while their lengths and fresh weights were decreased at salt concentrations （0.5% and 2%）. No significant effect was noticed on the formation time by using proline except at concentration of 25 mg L^-1 which caused an increase in their lengths and fresh weights. The interaction between all salt concentrations and proline （25 mg LL） caused a significant increase in the formation time as well as in their lengths and fresh weights. The addition of NaC1 to the media caused a significant effect on the germination time and a reduction on the percentages of somatic embryo germination starting at 2% and the following ones. A reduction in the lengths of radicals and the plumules of the formed embryos was noticed at 1.5% NaCI. Proline addition reduced the initial time and increased the germination percentages as well as the lengths of radicals and plumules. The interaction between salt and proline treatments caused a significant reduction in the initiation time and an increase in the germination percentages and lengths of radicals and plumules.展开更多
Background: The synergistic mixture of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera (STCD) aqueous extract is a common drink in Port Harcourt, Nigeria. It is assumed to have various health benefits. Howe...Background: The synergistic mixture of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera (STCD) aqueous extract is a common drink in Port Harcourt, Nigeria. It is assumed to have various health benefits. However, the synergistic mixture of the content has not been studied scientifically, hence the need to evaluate its effect on the liver and kidney being part of the body’s metabolic organs. Aim: This study evaluated the synergistic mixture of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera (STCD) aqueous extract in male albino rats. Methods: Acute toxicity LD<sub>50</sub> of STCD was carried out, afterwards, fifteen male albino rats were grouped into three groups with 5 rats in each group;Control, 200 mg/kg, 400 mg/kg STCD. The rats were administered STCD orally 24 hourly, for 21 days, with feed and water ad libitum. At the end of the experiment, blood samples were collected for biochemical analysis of the liver and kidney biomarkers, while the liver and kidney tissues were harvested for histopathological examination using standard laboratory methods. Descriptive statistics were computed and expressed as Mean ± SD. One-way ANOVA and Turkeys test was performed. P value ≤0.05 was considered statistically significant. Results: Acute toxicity LD50 of STCD was observed to be ≥2404.2 mg/kg body weight. An increase in the percentage body weight difference of 8.39% and 2.86% was observed for 200 and 400 mg/kg STCD groups. Also, the liver weight was observed to increase in 400 mg/kg (3.92 ± 1.42) in comparison to the control group (3.48 ± 1.61), a decrease in the kidney weight was observed in all groups administered STCD in comparison to the control group. Administration of STCD at both 200 and 400 mg/kg revealed a decrease in the concentration of the hepatic biomarkers AST, ALT, ALP, TP, Albumin, Total and conjugated bilirubin. The kidney biomarker Urea was observed to decrease in concentration for 200 mg/kg STCD (4.60 ± 1.83) and 400 mg/kg STCD (4.76 ± 0.74) when compared to the control group (6.32 ± 2.74). A decrease in Creatinine was observed in 200 mg/kg (91.80 ± 34.69) and 400 mg/kg (98.60 ± 15.53) in comparison to the control group (117.60 ± 42.88). The histological examination of the liver of rats administered STCD revealed structural normal central vein, hepatocytes and portal tract. The kidney examination revealed normal glomeruli and normal tubule. Conclusion: The findings of this study opine that STCD improved the health of both the liver and kidney as evidenced via the biomarkers and histological examinations of the liver and kidney. This study therefore recommends the intake of STCD at moderate doses for improved liver and kidney function due to its bioactive compounds and nutritional content.展开更多
The present study was carried out to verify the statistical relationships between the characteristic parameters in terms of vegetative aerial architecture of the date palms for simulating realistic 3D models. The vege...The present study was carried out to verify the statistical relationships between the characteristic parameters in terms of vegetative aerial architecture of the date palms for simulating realistic 3D models. The vegetal material was composed of two Tunisian varieties of Phoenix dactylifera L., ＂Barhi＂ and ＂Rochdi＂. The observations are taken place in Gabes and on one pair of palms per main stem and offshoot for each cultivar. The analysis of the characteristic dimensions of the pinnae and rachis allowed the determination of a minimum sample. The geometrical analysis confirmed the existence of a strong correlation between rotation angles and radial angles. The architectural analysis of the two Tunisian cultivars revealed that the distribution of characteristic parameter values of pinnae was the outcome ofa regionalized variable along the rachis. This statistical study of relationships between the characteristic parameters in terms of vegetative aerial architecture of the two varieties allows executing a new measurement protocol for computing and simulating realistic 3D models.展开更多
The architectural analysis of the young date palm （Phoenix dactylifera L.） root system （its form and its structure）, is necessary to describe its principal functions of absorption and anchoring. In this study the ...The architectural analysis of the young date palm （Phoenix dactylifera L.） root system （its form and its structure）, is necessary to describe its principal functions of absorption and anchoring. In this study the authors present an analysis of the root branching process. It allows them to understand the distribution of inter-lateral root length on the radicle and to account the development of the root system in the soil. Root architecture was studied from samples sprouted naturally in the oases of Chott el Ferikh （Gabes） and other plants grown in polyethylene bags under the shadow. This analysis has showed five categories of roots belonging to four different topological orders in the youthful phasis.展开更多
Date palm(Phoenix dactylifera L.)seeds,often discarded as by-products during date fruit processing,represent approximately 6-20%of the fruit’s mass depending on cultivar and maturity stage.Although traditionally used...Date palm(Phoenix dactylifera L.)seeds,often discarded as by-products during date fruit processing,represent approximately 6-20%of the fruit’s mass depending on cultivar and maturity stage.Although traditionally used for producing activated charcoal and in environmental remediation,their pharmacological potential remains underexplored.This study aimed to evaluate the chemical composition,biological activity,and potential commercial value of seeds from four widely consumed Saharan cultivars(Assiane,Boufegouss,Aziza,and Majhoul)collected in the Figuig region.Soxhlet extraction was employed to obtain seed extracts,which were subsequently characterized by qualitative and quantitative phytochemical screening.The analyses revealed the presence of polyphenols,flavonoids,terpenoids,steroids,alkaloids,and other secondary metabolites.The Aziza and Boufegouss varieties were particularly rich in flavonoids(82.09-139.61 mg quercetin equivalents/100 g dry matter)and total polyphenols(69.81-1183.96 mg gallic acid equivalents/100 g dry matter).Mineral profiling confirmed the occurrence of essential trace elements,including Zn,Cu,Fe,and Co.To investigate their antidiabetic potential,in vitro assays ofα-glucosidase andα-amylase inhibition were performed.Acetone extracts demonstrated significant inhibitory activity against both enzymes,suggesting a promising role of P.dactylifera seed extracts as natural agents for the management of type 2 diabetes mellitus.展开更多
The date syrups are processed traditionally from pulps of the date palm Phoenix dactylifera L.The pits,residues from the syrups production,are rich in bioactive compounds and could constitute an added value.The presen...The date syrups are processed traditionally from pulps of the date palm Phoenix dactylifera L.The pits,residues from the syrups production,are rich in bioactive compounds and could constitute an added value.The present study aims to promote Algerian dates of low market value and develop new food formulation of syrup from whole dates.Therefore,the physicochemical and sensory properties of the date syrups of three Algerian date varieties,namely H’mira,Ghars and Tantbouche,pitted and from entire fruits,were evaluated.The obtained results indicated that the incorporation of date pits was able to improve significantly the physicochemical and sensory properties of the new prepared syrups.In general,the physicochemical attributes of new syrups varied between samples.However,the syrup prepared by H’mira pits was most appreciated for its color,sweetness and brilliance and therefore received the highest hedonic preference score and purchase intent(2.75 and 2.69 respectively).Overall,date pits incorporation could improve significantly the composition and nutritional properties of date syrups.展开更多
Objective:To investigate the preventive,protective and ameliorative activity of the aqueous extract of Phoenix dactylifera L.(P.dactylifera)against paracetamol-induced hepatotoxicity.Methods:A total of 50 male albino ...Objective:To investigate the preventive,protective and ameliorative activity of the aqueous extract of Phoenix dactylifera L.(P.dactylifera)against paracetamol-induced hepatotoxicity.Methods:A total of 50 male albino rats were used for the study and 2 g/kg body weight of paracetamol and 400 mg/kg body weight of aqueous extract of P.dactylifera were administered orally for the study.They were divided into 5 groups,namely group A(vehicle control),group B(paracetamol control),group C(preventive),group D(ameliorative)and group E(protective),with 10 rats in each group.Group B was administered with paracetamol for 7 days;group C was administered with the extract for 7 days before administering with paracetamol for 7 days;group D was administered with paracetamol for 7 days,then the extract for 7 days;while group E was administered with paracetamol and the extract simultaneously for 7days.Results:The study revealed that the extracts of date palms contained active chemical compounds such as anthocyanins,phenolics,sterols,carotenoids and flavonoids.The levels of antioxidant enzymes activity such as superoxide dismutase,catalase,peroxidase were found to be reduced while malondialdehyde level was significantly increased in the paracetamol-treated group.This trend was reversed in groups where the extract was administered,as the antioxidant enzymes level in the liver was raised.Conclusions:This study has shown that the aqueous extract of P.dactylifera can mitigate the hepatotoxicity effect of paracetamol with a better ameliorating effect than protective or preventive.展开更多
Objective:Polycystic ovary syndrome(PCOS) is the most prevalent endocrine disorder in women of reproductive age.The objective of our investigation is to study the protective effect of hydroethanolic extract of palm me...Objective:Polycystic ovary syndrome(PCOS) is the most prevalent endocrine disorder in women of reproductive age.The objective of our investigation is to study the protective effect of hydroethanolic extract of palm meristem(HEPM) on female rats with PCOS.Materials and Methods:The experimental study involved the placement of 42 adult female Wistar rats(n=7) into six groups,with the control group rcceiving 0.25 ml of physiological serum by gavage daily,the sham group getting 0.25 ml of olive oil,and the HEPM 250,500,and 500 per se group taking HEPM by gavage daily.PCOS was induced with estradiol valerate(EV),which was administered through a subcutaneous inj ection at 2 mg/kg volume using 0.25 ml of olive oil.After experiments,all animals were subj ected to anesthe sia,and serums were extracted for biochemical and ho rmonal evaluation.Results:EV showed marked increases in serum levels of testosterone and luteinizing hormone when compared with the control group.Significantly,the EV group decreased 17-β estradiol,proge sterone,and follicle-stimulating hormone.There was a significant alteration in hormonal levels across the treatment groups.The serum malondialdehyde levels and total oxidant status were elevated in the EV group.In addition,the serum levels of total antioxidant capacity,glutathione,and glutathione peroxidase were significantly lower in the EV group than in control rats.In the treatment groups,HEPM significantly reverses the oxidant/antioxidant balance and ameliorates the adverse effect of PCOS on oxidative stress.Conclusion:The study findings indicated that the HEPM effectively safeguarded ovarian tissue from developing PCOS in the presence of EV.展开更多
Nutraceuticals and natural products are increasingly popular for their therapeutic potential and long-standing role in traditional medicine.Phoenix dactylifera,or the date palm,is recognized for its nutritional and me...Nutraceuticals and natural products are increasingly popular for their therapeutic potential and long-standing role in traditional medicine.Phoenix dactylifera,or the date palm,is recognized for its nutritional and medici-nal benefits and is gaining attention for its potential in neuropharmacological applications.The date palm’s neuroprotective potential is linked to its high phenolic content,which supports central nervous system(CNS)health and possibly prevents neurodegenerative diseases.Date palm extracts modulate neurotransmitters like acetylcholine,dopamine,and GABA,enhancing memory,cognitive function,and pain relief.Additionally,the plant exhibits aphrodisiac properties and may reduce anxiety,shorten labor,and ease labor pain during preg-nancy.Date palm phenolics combat oxidative stress and inhibit key inflammatory pathways by reducing pro-inflammatory cytokines like NF-κB,TNF-α,and IL-1β.It also suppresses the synthesis of eicosanoids,cyclooxygenase-2(COX-2),and nitric oxide synthase(NOS),all involved in inflammation.However,challenges such as poor bioavailability,enzymatic degradation,and limited blood-brain barrier(BBB)permeability hinder their therapeutic potential.Advanced encapsulation technologies,including liposomes,nanoemulsions,and polymeric micelles,offer effective solutions by protecting phenolics,enhancing bioavailability,and enabling targeted delivery to the brain,amplifying their efficacy.The phenolic content of date palms varies across cul-tivars,influencing their therapeutic properties and highlighting the importance of cultivar-specific profiling for targeted applications.This review explores the neuropharmacological effects of Phoenix dactylifera,emphasizing its phenolic compounds’therapeutic potential and the role of encapsulation technologies in overcoming key bioavailability and delivery challenges for CNS health management.展开更多
文摘Our overall knowledge of the medicinal uses of plants suggests that natural compounds could be useful in the treatment of cutaneous fungal infections in tropical regions. Furthermore, the possibilities of treatment using plant extracts may be even broader than is already known when one considers plants that have not been extensively studied in this context, such as the regional species Phoenix dactylifera and Ziziphus spina-christi. This study compared the antimicrobial activity of Phoenix dactylifera and Ziziphus spina-christi extracts in terms of their biochemical and molecular effects on Candida albicans (ATCC CA 10231). These effects included altered levels of intracellular sterols, changes in the permeability of the cell membrane, and changes in the TEF1: QRTTEF1, CaERG1: ERG1, CdERG12: CdERG1, and ERG25: ERG25 genes. Scanning electron microscopy (SEM) was used to identify morphological characteristics, and energy-dispersive X-ray spectroscopy (EDAX) analyses were conducted. In treated samples, the SEM and EDAX analyses showed cell cavities and shrinkage of the cell wall, and the number of cells was reduced to only a few abnormal cells as compared with that in the untreated samples. Yttrium was detected in the cells treated with Z. spina-christi, and high levels of osmium were detected in the cells treated with P. dactylifera. Compared with control cells, cells exposed to the concentration 150 μl/ml of Z. spina-christi extract had an average sterol concentration that was nearly 3 times higher, while the concentration was 5.5 times higher for cells treated with the 150 μl/ml of P. dactylifera extract. The ethanol extracts affected the permeability of C. albicans cell membrane. Gene sequencing showed gaps and mismatches in the ERG1, ERG12, and ERG25 genes after treatment with P. dactylifera and Z. spina-christi extracts compared with that in the controls. The results were highly significant (p ≤ 0.01). We conclude that the ethanol extracts of P. dactylifera and Z. spina-christi have antimicrobial activity through several mechanisms in the yeast cell.
基金supported by Grant from College of Medicine and Health Sciences,Sultan Qaboos University,Sultanate of Oman
文摘Objective: To investigate different types of dates and medical properties of influencing blood clotting and wound healing in an animal model. Methods: Three different cultivars of dates(Ajwa, Khalas, and Fardh) were examined in-vivo, for blood clotting and wound healing using CD1 mice of both sexes. Study of toxicity to animals was performed accordingly prior to further investigations. The ethanolic extracts were given orally to animals as a constituent in their daily water. Blood samples were obtained from the mice inferior vena cava to carry out the prothrombin time(PT) assay using the manual method and confirmed using a semi-automated machine. The bleeding time(BT) assay was performed using the cutting technique. In the wound healing analysis, a small cut(5-10 mm) in the skin overlying the thigh was conducted in all mice under anesthesia. The diameter of the cut and healing status were measured on a daily basis throughout the time of the experiment using a roller. Results: Ajwa was able to elevate both PT and BT(P<0.05), significantly in a time-dependent manner followed by Khalas date(P<0.05). The results of PT and BT of Fardh date were found to be very close to those of the control group(P<0.05). Despite its activity as an anticoagulant, Khalas date showed a potential property to enhance wound healing in contrast to other dates and the control groups in this study. Conclusions: Omani Khalas date fruit has both antithrombotic as well as wound healing properties. The results open a new gate with these fruits for exploring the potential component(s) that may play an important role in antithrombotic as well as wound healing process.
文摘Background: Dopamine has been known to facilitate male sexual function. Methods: The effect of aqueous extract (140 mg/kg) of Phoenix dactylifera date palm pollen on sexual behavior and determining of dopamine transmission in the nucleus accumbens was studied in male rats using in vivo microdialysis. Results: Releasing of dopamine increased significantly in the nucleus accumbens when a receptive female was introduced behind a screen (p 0.001). During copulation, dopamine increased markedly in control and treated rats. Phoenix dactylifera Date Palm Pollen enhanced the orientation of males towards females by increasing mounting and ano-genital investigatory behavior. Improving of sexual behavior and dopamine release was higher in treated rats in comparison with control (p 0.001). Conclusion: These results indicate a neurochemical basis for interaction between dopaminergic agents and male sexual behavior. Therefore, Phoenix dactylifera Date Palm Pollen seems to act as a dopamine agonist and to cure male infertility. It can be used as an aphrodisiac that leads to further increases in dopamine release.
文摘Aim of study: Ancient literature alluded to the use of a number of plants/preparations as sex enhancer. One of such botanicals is Phoenix dactylifera in which the pollen grain has been acclaimed to be used as an aphrodisiac. However, the validity has not been scientifically tested. Dopamine is known to facilitate male sexual function. Therefore, the present study was undertaken to evaluate the effect of aqueous extract of Phoenix dactylifera pollen on the sexual behavior of male rats and to measure of serum Estradiol and Testostrone. Also, dopamine transmission in the nucleus accumbence (NAc) was studied in male rats using in vivo microdialysis. Methods and Materials: sixty male rats were randomized into 6 groups (A-F). Group A received 0.2 ml of Normal Saline mixed with Dimethyl Sulphate (DMSO), while groups B-F were injected same volume containing 35 mg/kg, 70 mg/kg, 105 mg/kg, 140 mg/kg and 350 mg/kg of DPP extract, respectively. Sexual behavioral parameters including mounting, intromission and ejaculation frequencies and latencies were recorded in male rats one hour after injection of extract by mating with a receptive female (1:1). The male serum testosterone and estradiol concentrations were also determined. Results: All doses stimulated male sexual behavior. Extract significantly increased mount, ejaculation, intromission frequencies and ejaculation latency in comparison to controlled ones (p 0.001). Mount and intromission latencies significantly reduced (p 0.001). Maximum effect was observed in dose 140 mg/kg. This extract was found to enhance Testestrone, Estradiol and the orientation of males toward female ones by increasing mounting and ano-genital investigatory behavior. Conclusions: Data from this study identified that the aqueous extract of Phoenix dactylifera pollen grain enhanced sexual behaviour in male rats. The improved sexual appetitive behaviour in male rats may be attributed, to the alkaloids, saponins, and or flavonoids since these phytochemicals has engorgement, androgen enhancing. Also, our findings support the traditional use of this plant as acclaimed aphrodisiac and for the treatment of pre-ejaculation and impotency.
基金Supported by Faculty Mentored Undergraduate Research Award Program scheme wide grant No FRP/OMC/14/002
文摘Objective:To evaluate and compare the antioxidant activity,total phenolic contents(TPCs) and in vitro antidiabetic activity of various pits extracts obtained from five Omani date cultivars.Methods:Sun-dried mature fruits of five Omani date varieties,namely,Fardh,Naghal,Khalas,Khinazi and Khasab were purchased from the local market in Muscat,Oman in the month of September 2014.Four seed extracts viz.water,ethanol,methanol and acetone were prepared for each date variety and their antioxidant activities were investigated by 1,1-diphenyl-2-picrylhydrazyl,hydrogen peroxide scavenging method and reducing power assay method,respectively.In vitro antidiabetic activity of the date pit extracts was evaluated by measuring their inhibitory effect on a-glucosidase and aamylase level.TPCs were also quantified colorimetrically.Results:The results indicated that TPC of date seeds was solvent dependent.Acetone,ethanol and methanol were found to be significantly better solvents than water in extracting phenolic compounds from the date seeds.Pit extracts exhibited moderate to good in vitro antioxidant activity and increased reducing power.Among all date pit extracts,water extract exhibited significant in vitro antidiabetic activity in comparison to standard drug,acarbose.Conclusions:The present study confirms that disposed waste of Omani dates is a rich source of dietary antioxidant because of its high TPC.The pits due to their inhibitory effects on a-glucosidase and a-amylase level could be used as a monotherapy along with an appropriate diabetic diet and exercise or might be in conjunction with antidiabetic therapy to manage and prevent progression of diabetes.
基金supported by EGIDE(No.18470SA),CMCU(No.08G908)the Tunisian Ministry of Higher Education
文摘Endophytic flora plays a vital role in the colonization and survival of host plants, especially in harsh environments, such as arid regions. This flora may, however, contain pathogenic species responsible for various troublesome host diseases. The present study is aimed at investigating the diversity of both cultivable and non-cultivable endophytic fungal floras in the internal tissues(roots and leaves) of Tunisian date palm trees(Phoenix dactylifera). Accordingly, 13 isolates from both root and leaf samples, exhibiting distinct colony morphology, were selected from potato dextrose agar(PDA) medium and identified by a sequence match search wherein their 18S–28S internal transcribed spacer(ITS) sequences were compared to those available in public databases. These findings revealed that the cultivable root and leaf isolates fell into two groups, namely Nectriaceae and Pleosporaceae. Additionally, total DNA from palm roots and leaves was further extracted and ITS fragments were amplified. Restriction fragment length polymorphism(RFLP) analysis of the ITS from 200 fungal clones(leaves: 100; roots: 100) using HaeIII restriction enzyme revealed 13 distinct patterns that were further sequenced and led to the identification of Alternaria, Cladosporium, Davidiella(Cladosporium teleomorph), Pythium, Curvularia, and uncharacterized fungal endophytes. Both approaches confirmed that while the roots were predominantly colonized by Fusaria(members of the Nectriaceae family), the leaves were essentially colonized by Alternaria(members of the Pleosporaceae family). Overall, the findings of the present study constitute, to the authors' knowledge, the first extensive report on the diversity of endophytic fungal flora associated with date palm trees(P. dactylifera).
文摘Objective: To estimate the effects of the water extract of dates palm (Phoenix dactylifera) (DWE) on sperm quality parameters, testosterone level and serum antioxidants activities of New Zealand rabbits under heat stress. Methods: A total of 30 bucks of New Zealand White rabbits were randomly divided into three equal groups as follows: Group 1 was treated as control group and fed on balanced commercial ration. Groups 2 and 3 were treated with 10 and 20 mL of dates extract substituting water in the early morning before watering and fed on balanced commercial ration. This schedule was performed daily for 5 days/week, for an experimental period of 5 weeks. Fertility parameters such as reaction time, potential of hydrogen ion (pH), mass motility, individual progressive motility %, percentage of live sperm and abnormal sperm (%) were measured. Blood serum testosterone level, serum glutathione reduced, nitric oxide, ascorbic acid and malondialdehyde were also determined. Results: The daily oral administration of 10 mL DWE significantly increased the pH, the mass motility and individual progressive motility % compared to the control group. Although, the consumption of 20 mL DWE significantly (P<0.0001) increased the live sperm% and decreased the abnormal sperm % compared to the other two treatments. The administration of date extracts (10 and 20 mL) had significantly (P<0.0001) decreased nitric oxide and glutathione reduced levels compared to the control. On the other hand, it increased significantly the lipid peroxidation, ascorbic acid and testosterone level compared to the control. Conclusions:The aqueous extract of date palm (10-20 mL) could enhance the rabbit bucks fertility and its health performance.
文摘Phoenix dactylifera(Fam:Arecaceae)is originated from the Mesopotamia.The date fruit,was eaten fresh,in various processed forms and dried.The fruits were used traditionally as general tonic,for the treatment of liver diseases,memory disturbances,fever,inflammation,paralysis,loss of consciousness,nervous disorders and consumed by pregnant women before and after delivery.However,all parts of the plant were used for some purpose.Dates fruits were considered a complete diet and a very important item of food,with plenty of vitamins and minerals.It contained a wide range of secondary metabolites.It possessed many pharmacological effects included anticancer,antidiabetic,anti-inflammatory,antimicrobial,antiparasitic,antioxidant,anti-toxin,cardiovascular,hypolipidemic,gastrointestinal,immunomodullatory,neural,hepato and reno-protective,reproductive and wound healing effects.This review highlighted the chemical constituents,nutritional and pharmacological effects of Phoenix dactylifera.
文摘The effect of NaCI and proline on somatic embryos formation and germination of date palm （Phoenix dactylifera L.） cv. Barhee was studied. Quarters of shoot tips were cultured on MS solid growth media supplied with different concentrations of salt （NaCI） （0.5%, 1%, 1.5%, 2%, 2.5% and 3%, respectively） and proline （25, 50 and 75 mg L1） either individually or in combination. Results showed that the addition of NaC1 （starting at 1%） caused a significant increase in the cylindrical embryos formation time, while their lengths and fresh weights were decreased at salt concentrations （0.5% and 2%）. No significant effect was noticed on the formation time by using proline except at concentration of 25 mg L^-1 which caused an increase in their lengths and fresh weights. The interaction between all salt concentrations and proline （25 mg LL） caused a significant increase in the formation time as well as in their lengths and fresh weights. The addition of NaC1 to the media caused a significant effect on the germination time and a reduction on the percentages of somatic embryo germination starting at 2% and the following ones. A reduction in the lengths of radicals and the plumules of the formed embryos was noticed at 1.5% NaCI. Proline addition reduced the initial time and increased the germination percentages as well as the lengths of radicals and plumules. The interaction between salt and proline treatments caused a significant reduction in the initiation time and an increase in the germination percentages and lengths of radicals and plumules.
文摘Background: The synergistic mixture of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera (STCD) aqueous extract is a common drink in Port Harcourt, Nigeria. It is assumed to have various health benefits. However, the synergistic mixture of the content has not been studied scientifically, hence the need to evaluate its effect on the liver and kidney being part of the body’s metabolic organs. Aim: This study evaluated the synergistic mixture of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera (STCD) aqueous extract in male albino rats. Methods: Acute toxicity LD<sub>50</sub> of STCD was carried out, afterwards, fifteen male albino rats were grouped into three groups with 5 rats in each group;Control, 200 mg/kg, 400 mg/kg STCD. The rats were administered STCD orally 24 hourly, for 21 days, with feed and water ad libitum. At the end of the experiment, blood samples were collected for biochemical analysis of the liver and kidney biomarkers, while the liver and kidney tissues were harvested for histopathological examination using standard laboratory methods. Descriptive statistics were computed and expressed as Mean ± SD. One-way ANOVA and Turkeys test was performed. P value ≤0.05 was considered statistically significant. Results: Acute toxicity LD50 of STCD was observed to be ≥2404.2 mg/kg body weight. An increase in the percentage body weight difference of 8.39% and 2.86% was observed for 200 and 400 mg/kg STCD groups. Also, the liver weight was observed to increase in 400 mg/kg (3.92 ± 1.42) in comparison to the control group (3.48 ± 1.61), a decrease in the kidney weight was observed in all groups administered STCD in comparison to the control group. Administration of STCD at both 200 and 400 mg/kg revealed a decrease in the concentration of the hepatic biomarkers AST, ALT, ALP, TP, Albumin, Total and conjugated bilirubin. The kidney biomarker Urea was observed to decrease in concentration for 200 mg/kg STCD (4.60 ± 1.83) and 400 mg/kg STCD (4.76 ± 0.74) when compared to the control group (6.32 ± 2.74). A decrease in Creatinine was observed in 200 mg/kg (91.80 ± 34.69) and 400 mg/kg (98.60 ± 15.53) in comparison to the control group (117.60 ± 42.88). The histological examination of the liver of rats administered STCD revealed structural normal central vein, hepatocytes and portal tract. The kidney examination revealed normal glomeruli and normal tubule. Conclusion: The findings of this study opine that STCD improved the health of both the liver and kidney as evidenced via the biomarkers and histological examinations of the liver and kidney. This study therefore recommends the intake of STCD at moderate doses for improved liver and kidney function due to its bioactive compounds and nutritional content.
文摘The present study was carried out to verify the statistical relationships between the characteristic parameters in terms of vegetative aerial architecture of the date palms for simulating realistic 3D models. The vegetal material was composed of two Tunisian varieties of Phoenix dactylifera L., ＂Barhi＂ and ＂Rochdi＂. The observations are taken place in Gabes and on one pair of palms per main stem and offshoot for each cultivar. The analysis of the characteristic dimensions of the pinnae and rachis allowed the determination of a minimum sample. The geometrical analysis confirmed the existence of a strong correlation between rotation angles and radial angles. The architectural analysis of the two Tunisian cultivars revealed that the distribution of characteristic parameter values of pinnae was the outcome ofa regionalized variable along the rachis. This statistical study of relationships between the characteristic parameters in terms of vegetative aerial architecture of the two varieties allows executing a new measurement protocol for computing and simulating realistic 3D models.
文摘The architectural analysis of the young date palm （Phoenix dactylifera L.） root system （its form and its structure）, is necessary to describe its principal functions of absorption and anchoring. In this study the authors present an analysis of the root branching process. It allows them to understand the distribution of inter-lateral root length on the radicle and to account the development of the root system in the soil. Root architecture was studied from samples sprouted naturally in the oases of Chott el Ferikh （Gabes） and other plants grown in polyethylene bags under the shadow. This analysis has showed five categories of roots belonging to four different topological orders in the youthful phasis.
文摘Date palm(Phoenix dactylifera L.)seeds,often discarded as by-products during date fruit processing,represent approximately 6-20%of the fruit’s mass depending on cultivar and maturity stage.Although traditionally used for producing activated charcoal and in environmental remediation,their pharmacological potential remains underexplored.This study aimed to evaluate the chemical composition,biological activity,and potential commercial value of seeds from four widely consumed Saharan cultivars(Assiane,Boufegouss,Aziza,and Majhoul)collected in the Figuig region.Soxhlet extraction was employed to obtain seed extracts,which were subsequently characterized by qualitative and quantitative phytochemical screening.The analyses revealed the presence of polyphenols,flavonoids,terpenoids,steroids,alkaloids,and other secondary metabolites.The Aziza and Boufegouss varieties were particularly rich in flavonoids(82.09-139.61 mg quercetin equivalents/100 g dry matter)and total polyphenols(69.81-1183.96 mg gallic acid equivalents/100 g dry matter).Mineral profiling confirmed the occurrence of essential trace elements,including Zn,Cu,Fe,and Co.To investigate their antidiabetic potential,in vitro assays ofα-glucosidase andα-amylase inhibition were performed.Acetone extracts demonstrated significant inhibitory activity against both enzymes,suggesting a promising role of P.dactylifera seed extracts as natural agents for the management of type 2 diabetes mellitus.
文摘The date syrups are processed traditionally from pulps of the date palm Phoenix dactylifera L.The pits,residues from the syrups production,are rich in bioactive compounds and could constitute an added value.The present study aims to promote Algerian dates of low market value and develop new food formulation of syrup from whole dates.Therefore,the physicochemical and sensory properties of the date syrups of three Algerian date varieties,namely H’mira,Ghars and Tantbouche,pitted and from entire fruits,were evaluated.The obtained results indicated that the incorporation of date pits was able to improve significantly the physicochemical and sensory properties of the new prepared syrups.In general,the physicochemical attributes of new syrups varied between samples.However,the syrup prepared by H’mira pits was most appreciated for its color,sweetness and brilliance and therefore received the highest hedonic preference score and purchase intent(2.75 and 2.69 respectively).Overall,date pits incorporation could improve significantly the composition and nutritional properties of date syrups.
基金Supported by University of Benin(Grant No.PGLSC1209388C).
文摘Objective:To investigate the preventive,protective and ameliorative activity of the aqueous extract of Phoenix dactylifera L.(P.dactylifera)against paracetamol-induced hepatotoxicity.Methods:A total of 50 male albino rats were used for the study and 2 g/kg body weight of paracetamol and 400 mg/kg body weight of aqueous extract of P.dactylifera were administered orally for the study.They were divided into 5 groups,namely group A(vehicle control),group B(paracetamol control),group C(preventive),group D(ameliorative)and group E(protective),with 10 rats in each group.Group B was administered with paracetamol for 7 days;group C was administered with the extract for 7 days before administering with paracetamol for 7 days;group D was administered with paracetamol for 7 days,then the extract for 7 days;while group E was administered with paracetamol and the extract simultaneously for 7days.Results:The study revealed that the extracts of date palms contained active chemical compounds such as anthocyanins,phenolics,sterols,carotenoids and flavonoids.The levels of antioxidant enzymes activity such as superoxide dismutase,catalase,peroxidase were found to be reduced while malondialdehyde level was significantly increased in the paracetamol-treated group.This trend was reversed in groups where the extract was administered,as the antioxidant enzymes level in the liver was raised.Conclusions:This study has shown that the aqueous extract of P.dactylifera can mitigate the hepatotoxicity effect of paracetamol with a better ameliorating effect than protective or preventive.
文摘Objective:Polycystic ovary syndrome(PCOS) is the most prevalent endocrine disorder in women of reproductive age.The objective of our investigation is to study the protective effect of hydroethanolic extract of palm meristem(HEPM) on female rats with PCOS.Materials and Methods:The experimental study involved the placement of 42 adult female Wistar rats(n=7) into six groups,with the control group rcceiving 0.25 ml of physiological serum by gavage daily,the sham group getting 0.25 ml of olive oil,and the HEPM 250,500,and 500 per se group taking HEPM by gavage daily.PCOS was induced with estradiol valerate(EV),which was administered through a subcutaneous inj ection at 2 mg/kg volume using 0.25 ml of olive oil.After experiments,all animals were subj ected to anesthe sia,and serums were extracted for biochemical and ho rmonal evaluation.Results:EV showed marked increases in serum levels of testosterone and luteinizing hormone when compared with the control group.Significantly,the EV group decreased 17-β estradiol,proge sterone,and follicle-stimulating hormone.There was a significant alteration in hormonal levels across the treatment groups.The serum malondialdehyde levels and total oxidant status were elevated in the EV group.In addition,the serum levels of total antioxidant capacity,glutathione,and glutathione peroxidase were significantly lower in the EV group than in control rats.In the treatment groups,HEPM significantly reverses the oxidant/antioxidant balance and ameliorates the adverse effect of PCOS on oxidative stress.Conclusion:The study findings indicated that the HEPM effectively safeguarded ovarian tissue from developing PCOS in the presence of EV.
文摘Nutraceuticals and natural products are increasingly popular for their therapeutic potential and long-standing role in traditional medicine.Phoenix dactylifera,or the date palm,is recognized for its nutritional and medici-nal benefits and is gaining attention for its potential in neuropharmacological applications.The date palm’s neuroprotective potential is linked to its high phenolic content,which supports central nervous system(CNS)health and possibly prevents neurodegenerative diseases.Date palm extracts modulate neurotransmitters like acetylcholine,dopamine,and GABA,enhancing memory,cognitive function,and pain relief.Additionally,the plant exhibits aphrodisiac properties and may reduce anxiety,shorten labor,and ease labor pain during preg-nancy.Date palm phenolics combat oxidative stress and inhibit key inflammatory pathways by reducing pro-inflammatory cytokines like NF-κB,TNF-α,and IL-1β.It also suppresses the synthesis of eicosanoids,cyclooxygenase-2(COX-2),and nitric oxide synthase(NOS),all involved in inflammation.However,challenges such as poor bioavailability,enzymatic degradation,and limited blood-brain barrier(BBB)permeability hinder their therapeutic potential.Advanced encapsulation technologies,including liposomes,nanoemulsions,and polymeric micelles,offer effective solutions by protecting phenolics,enhancing bioavailability,and enabling targeted delivery to the brain,amplifying their efficacy.The phenolic content of date palms varies across cul-tivars,influencing their therapeutic properties and highlighting the importance of cultivar-specific profiling for targeted applications.This review explores the neuropharmacological effects of Phoenix dactylifera,emphasizing its phenolic compounds’therapeutic potential and the role of encapsulation technologies in overcoming key bioavailability and delivery challenges for CNS health management.
