Two new cyclic peptides, polycarponin B and C (1, 2), were isolated from the whole plants of Polycarpon prostratum (Forssk.) Aschers. et Schwein. ex Aschers. By detailed spectroscopic analysis, their structures were d...Two new cyclic peptides, polycarponin B and C (1, 2), were isolated from the whole plants of Polycarpon prostratum (Forssk.) Aschers. et Schwein. ex Aschers. By detailed spectroscopic analysis, their structures were determined as cyclo(-Gly(1)-Ile-Val(1)-Leu(1)-Val(2)-Gly(2)-Leu(2)-Pro) and cyclo(-Pro(1)-Thr-Leu(1)-Pro(2)-Pro(3)-Val-Leu(2)-Phe), respectively.展开更多
New minor cyclic peptides, named arenariphilin C 1 and arenariphilin D 2, were isolated from the whole plants of Arenaria oreophila （Caryophyllaceae）. Their structures were determined as cyclo（Pro^1-Pro2-Leu^1-Leu2...New minor cyclic peptides, named arenariphilin C 1 and arenariphilin D 2, were isolated from the whole plants of Arenaria oreophila （Caryophyllaceae）. Their structures were determined as cyclo（Pro^1-Pro2-Leu^1-Leu2-Phe-Ser-Gly-Thr） and cyclo （Ser-Cys） on the basis of spectroscopic data, especially by two-dimension NMR （2D NMR） technologies.展开更多
Two cyclopeptides, celogentin L(1) and its epimer lyciumin A(2) were firstly isolated from Celosia argentea L.. The planar structures of the two compounds were fully determined by spectroscopic data, including 1 D-, 2...Two cyclopeptides, celogentin L(1) and its epimer lyciumin A(2) were firstly isolated from Celosia argentea L.. The planar structures of the two compounds were fully determined by spectroscopic data, including 1 D-, 2 D-NMR, and HR-ESI/MS. The absolute configurations of amino acid components were assigned via chiral-phase HPLC analyses after acid hydrolysis. Furthermore, the configuration of C-N linkage at the glycine Cα was elucidated by extensive analyses of 2 D-NMR and comparison of the experimental and calculated electronic circular dichroism(ECD) spectra. Cytotoxicity of the two compounds against human alveolar epithelial A549, hepatocellular carcinoma Hep G2, and cervical cancer Hela cell lines was assayed. Although both of them were inactive in these cells, the present findings add new facets for the chemistry of Celosia argentea.展开更多
Two cyclopeptides,heterophyllin A and B,have been isolated from the roots of Pseudostellaria heterophylla.Their structures were elucidated by chemical, spectroscopic,and enzymatic methods.
Two new cyclopeptides, leiocyclocin A (1); B (2), were isolated from the seeds of Goniothalanus leiocarpus. Their structures were elucidated by means of spectral and chemical methods.
A new cyclic peptide named polycarponin A, was isolated from the whole plants of Polycarpon prostratum. Its structure was determined by detailed spectroscopic analysis.
A new cyclopeptide as well as a known cyclopeptide were isolated from the whole plants of Dianthus caryophyllus. Their structures were elucidated as cyclo （-Thr-Gly-Pro-Tyr-Phe-） （1） and cyclo （-Ala-Gly-Ser-IIe-P...A new cyclopeptide as well as a known cyclopeptide were isolated from the whole plants of Dianthus caryophyllus. Their structures were elucidated as cyclo （-Thr-Gly-Pro-Tyr-Phe-） （1） and cyclo （-Ala-Gly-Ser-IIe-Phe-Phe-） （2） by means of chemical and spectroscopic methods including MS, 1D and 2D NMR techniques.展开更多
Based on the pseudo-dilution effect (PDE) on solid support, three cyclopeptides with an aliphatic-aryl ether bond as the bridge were synthesized via SN2 reaction between bromoacetylated at N-terminal and the phenol –...Based on the pseudo-dilution effect (PDE) on solid support, three cyclopeptides with an aliphatic-aryl ether bond as the bridge were synthesized via SN2 reaction between bromoacetylated at N-terminal and the phenol –OH group in C-terminal Tyr residue. All the products were obtained in good overall yields and characterized by related analytic data.展开更多
A new cyclic nonapeptide, amanexitide (1), along with the known cyclopeptides, a- and b-amanitins, was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom endemic to Guangzhou,...A new cyclic nonapeptide, amanexitide (1), along with the known cyclopeptides, a- and b-amanitins, was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom endemic to Guangzhou, Guangdong Province, China. Its amino acid composition and absolute configuration were determined by chemical degradation and derivatization followed by chiral GC analysis. Its amino acid sequence was elucidated by extensive analysis of ESIMS/MS and FTICRMS data. The occurrence of 1 in this mushroom is interesting because it has a structure closely related to antamanide, a cyclic decapeptide with antidote activity against amatoxins and phallotoxins, occurring in A. phalloides.展开更多
A novel cyclopeptide, squamin-A has been isolated from the seeds of Annona squamosa Linn.. The structure was elucidated by extensive 2D-NMR, FABMS and amino acid analysis in combination with Marfey's reagents as c...A novel cyclopeptide, squamin-A has been isolated from the seeds of Annona squamosa Linn.. The structure was elucidated by extensive 2D-NMR, FABMS and amino acid analysis in combination with Marfey's reagents as cyclo-[l-prolyl-l-(S-oxo)-methionyl-l-tyrosyl-l-glycyl-tythreonyl-l-valyl-l-alanyl-l-isoleucyl].展开更多
文摘Two new cyclic peptides, polycarponin B and C (1, 2), were isolated from the whole plants of Polycarpon prostratum (Forssk.) Aschers. et Schwein. ex Aschers. By detailed spectroscopic analysis, their structures were determined as cyclo(-Gly(1)-Ile-Val(1)-Leu(1)-Val(2)-Gly(2)-Leu(2)-Pro) and cyclo(-Pro(1)-Thr-Leu(1)-Pro(2)-Pro(3)-Val-Leu(2)-Phe), respectively.
文摘New minor cyclic peptides, named arenariphilin C 1 and arenariphilin D 2, were isolated from the whole plants of Arenaria oreophila （Caryophyllaceae）. Their structures were determined as cyclo（Pro^1-Pro2-Leu^1-Leu2-Phe-Ser-Gly-Thr） and cyclo （Ser-Cys） on the basis of spectroscopic data, especially by two-dimension NMR （2D NMR） technologies.
基金financially supported by the National Natural Science Foundation of China(Nos.81322051 and 31400300)the Natural Science Foundation of Jiangsu Province(No.BK20151442)the Project Funded by the Priority Academic Program Development(PAPD) of Jiangsu Higher Education Institutions
文摘Two cyclopeptides, celogentin L(1) and its epimer lyciumin A(2) were firstly isolated from Celosia argentea L.. The planar structures of the two compounds were fully determined by spectroscopic data, including 1 D-, 2 D-NMR, and HR-ESI/MS. The absolute configurations of amino acid components were assigned via chiral-phase HPLC analyses after acid hydrolysis. Furthermore, the configuration of C-N linkage at the glycine Cα was elucidated by extensive analyses of 2 D-NMR and comparison of the experimental and calculated electronic circular dichroism(ECD) spectra. Cytotoxicity of the two compounds against human alveolar epithelial A549, hepatocellular carcinoma Hep G2, and cervical cancer Hela cell lines was assayed. Although both of them were inactive in these cells, the present findings add new facets for the chemistry of Celosia argentea.
文摘Two cyclopeptides,heterophyllin A and B,have been isolated from the roots of Pseudostellaria heterophylla.Their structures were elucidated by chemical, spectroscopic,and enzymatic methods.
基金This work was supported by the National Natural Science Foundation of China(Grant No.39770089)the Applied and Basic Rcscarch Foundation of Yunnan province(Grant No.97B038q).
文摘Two new cyclopeptides, leiocyclocin A (1); B (2), were isolated from the seeds of Goniothalanus leiocarpus. Their structures were elucidated by means of spectral and chemical methods.
文摘A new cyclic peptide named polycarponin A, was isolated from the whole plants of Polycarpon prostratum. Its structure was determined by detailed spectroscopic analysis.
基金supported by the Natural Science Foundation of Ynunan Province(No.2007B021M)Yurman University(No.2003Q008A).
文摘A new cyclopeptide as well as a known cyclopeptide were isolated from the whole plants of Dianthus caryophyllus. Their structures were elucidated as cyclo （-Thr-Gly-Pro-Tyr-Phe-） （1） and cyclo （-Ala-Gly-Ser-IIe-Phe-Phe-） （2） by means of chemical and spectroscopic methods including MS, 1D and 2D NMR techniques.
文摘Based on the pseudo-dilution effect (PDE) on solid support, three cyclopeptides with an aliphatic-aryl ether bond as the bridge were synthesized via SN2 reaction between bromoacetylated at N-terminal and the phenol –OH group in C-terminal Tyr residue. All the products were obtained in good overall yields and characterized by related analytic data.
基金This work was supported by the Knowledge Innovation Program of the Chinese Academy of Sciences(No.KSCX2-YW-N-036).
文摘A new cyclic nonapeptide, amanexitide (1), along with the known cyclopeptides, a- and b-amanitins, was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom endemic to Guangzhou, Guangdong Province, China. Its amino acid composition and absolute configuration were determined by chemical degradation and derivatization followed by chiral GC analysis. Its amino acid sequence was elucidated by extensive analysis of ESIMS/MS and FTICRMS data. The occurrence of 1 in this mushroom is interesting because it has a structure closely related to antamanide, a cyclic decapeptide with antidote activity against amatoxins and phallotoxins, occurring in A. phalloides.
文摘A novel cyclopeptide, squamin-A has been isolated from the seeds of Annona squamosa Linn.. The structure was elucidated by extensive 2D-NMR, FABMS and amino acid analysis in combination with Marfey's reagents as cyclo-[l-prolyl-l-(S-oxo)-methionyl-l-tyrosyl-l-glycyl-tythreonyl-l-valyl-l-alanyl-l-isoleucyl].
