Analysis using historical data on the phosphate sources in Changjiang （Yangtze River） estuary show that phosphate was supplied equally from the east, south, west and north of the estuary. These sources include the C...Analysis using historical data on the phosphate sources in Changjiang （Yangtze River） estuary show that phosphate was supplied equally from the east, south, west and north of the estuary. These sources include the Changjiang River, the Taiwan Warm Current （TWC）, a cyclone-type eddy, and the 32°N Upwelling, supplying different phosphates in different times, ways and intensities. The magnitude of their supplying phosphate concentration was related with the size in the order of the Changjiang River 〈 the TWC 〈 the 32°N Upwelling 〈 the cyclone-type eddy, and the duration of the supplying was： the Changjiang River 〉 the TWC 〉 the cyclone-type eddy 〉 the 32°N Upwelling. The four sources supplied a great deal of phosphate so that the phosphate concentration in the estuary was kept above 0.2 pmol/L in previous years, satisfying the phytoplankton growth. The horizontal and vertical distribution of the phosphate concentration showed that near shallow marine areas at 122°E/31°N, the TWC in low nutrient concentration became an upwelling through sea bottom and brought up nutrients from sea bottom to marine surface. In addition, horizontal distribution of phosphate concentration was consistent with that of algae： Rhizosolenia robusta, Rhizosolenia calcaravis and Skeletonema, which showed that no matter during high water or low water of Changjiang River, these species brought by the TWC became predominant species. Therefore, the authors believe that the TWC flowed from south to north along the coast and played a role in deflecting the Changjiang River flow from the southern side.展开更多
Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular drug.The traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable yields.Herein,a sequential contin...Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular drug.The traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable yields.Herein,a sequential continuous flow synthesis combined with a multistage in-line purification process of calcium dibutyryladenosine cyclophosphate was developed.The acylation reaction was completed in a continuous coil reactor at 160℃in 20 min.And the high toxic solvent pyridine was replaced by acetonitrile.Furthermore,the multistage in-line purification process was integrated into the homemade 3D circular cyclone-type micromixer chip.Combining with the membrane phase separators,the residence time of the purification step was 30 s.The isolated yield of this sequential continuous process was 92%with 99%purity.展开更多
基金Supported by Key Laboratory of Marine Spill Oil Identification and Damage Assessment Technology,SOA,the Director's Foundation of the North Sea Monitoring CenterChinese Academy of Sciences (No.KZCX 2-207)the Project of Ecological Environment in Fishery and Technology Controlling Pollution in Zhoushan Fishing Ground (No.2007c23075)
文摘Analysis using historical data on the phosphate sources in Changjiang （Yangtze River） estuary show that phosphate was supplied equally from the east, south, west and north of the estuary. These sources include the Changjiang River, the Taiwan Warm Current （TWC）, a cyclone-type eddy, and the 32°N Upwelling, supplying different phosphates in different times, ways and intensities. The magnitude of their supplying phosphate concentration was related with the size in the order of the Changjiang River 〈 the TWC 〈 the 32°N Upwelling 〈 the cyclone-type eddy, and the duration of the supplying was： the Changjiang River 〉 the TWC 〉 the cyclone-type eddy 〉 the 32°N Upwelling. The four sources supplied a great deal of phosphate so that the phosphate concentration in the estuary was kept above 0.2 pmol/L in previous years, satisfying the phytoplankton growth. The horizontal and vertical distribution of the phosphate concentration showed that near shallow marine areas at 122°E/31°N, the TWC in low nutrient concentration became an upwelling through sea bottom and brought up nutrients from sea bottom to marine surface. In addition, horizontal distribution of phosphate concentration was consistent with that of algae： Rhizosolenia robusta, Rhizosolenia calcaravis and Skeletonema, which showed that no matter during high water or low water of Changjiang River, these species brought by the TWC became predominant species. Therefore, the authors believe that the TWC flowed from south to north along the coast and played a role in deflecting the Changjiang River flow from the southern side.
基金supported by the National Natural Science Foundation of China(No.22278087)。
文摘Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular drug.The traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable yields.Herein,a sequential continuous flow synthesis combined with a multistage in-line purification process of calcium dibutyryladenosine cyclophosphate was developed.The acylation reaction was completed in a continuous coil reactor at 160℃in 20 min.And the high toxic solvent pyridine was replaced by acetonitrile.Furthermore,the multistage in-line purification process was integrated into the homemade 3D circular cyclone-type micromixer chip.Combining with the membrane phase separators,the residence time of the purification step was 30 s.The isolated yield of this sequential continuous process was 92%with 99%purity.
