Cyclodextrin 1 was directly oxidized to the corresponding monoaldehyde 2 on their primary faces by cyclized 2-iodoxybenzoic acid(IBX) in DMSO, followed by the synthesis of β-cyclodextrin derivatives bearing Schiff-ba...Cyclodextrin 1 was directly oxidized to the corresponding monoaldehyde 2 on their primary faces by cyclized 2-iodoxybenzoic acid(IBX) in DMSO, followed by the synthesis of β-cyclodextrin derivatives bearing Schiff-base group 3. A new chiral stationary phase(BCDS 6) was then prepared by immobilization of β-cyclodextrin derivative with α-Schiff base group onto the surface of sillica gel. A series of compounds with amino groups were readily separated using this CSP. Methanol and acetonitrile were tested as the mobile phase while the influence of temperature and the addition of aqueous triethylammonium acetate buffer to the mobile phase was also innvestigated. Ferrocene ligand with Schiff-based groups have been separated satisfactorilly on BCDS column.展开更多
Here we have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carrier and folic acid as a targeting ligand. Folic acid was selected as a cancer targeting ligand because folic a...Here we have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carrier and folic acid as a targeting ligand. Folic acid was selected as a cancer targeting ligand because folic acid receptors are highly expressed in a variety of tumor types. β-cyclodextrin and folic acid were connected through a linker [1,10-phenanthroline or 5-(hydroxymethyl) furfural]. β-cyclodextrin and folic acid were attached to the linker by formation of Schiffbase and ester, respectively. Our targeted synthetic products were confirmed by NMR, Mass and IR spectroscopy. We anticipate that our synthetic products can confer cancer cell-specific drug delivery as well as desired properties such as nanoparticle formation.展开更多
Two chiral stationary phases(BCDs and YBCDs) were prepared by bonding β-cyclodextrin derivative with α-Schiff base group from β-cyclodextrin monoaldehyde to the sillica gel via 3-glyci-{dyloxypropyltrimethoxysilane...Two chiral stationary phases(BCDs and YBCDs) were prepared by bonding β-cyclodextrin derivative with α-Schiff base group from β-cyclodextrin monoaldehyde to the sillica gel via 3-glyci-{dyloxypropyltrimethoxysilane} as a coupling agent. Using acetonitrile-TEAA as mobile phase, good enantiomeric resolutions were obtained for DL-aminoacide on BCDs and YBCDs, including Leucine, Threonine and Valine. It is also observed that the higher separation factor of threonine was at pH {7.11} for both of the column, and the optimal column temperatures of Leucine appeared at 30 ℃ or {40 ℃}, respectively for YBCDs and BCDs.展开更多
文摘Cyclodextrin 1 was directly oxidized to the corresponding monoaldehyde 2 on their primary faces by cyclized 2-iodoxybenzoic acid(IBX) in DMSO, followed by the synthesis of β-cyclodextrin derivatives bearing Schiff-base group 3. A new chiral stationary phase(BCDS 6) was then prepared by immobilization of β-cyclodextrin derivative with α-Schiff base group onto the surface of sillica gel. A series of compounds with amino groups were readily separated using this CSP. Methanol and acetonitrile were tested as the mobile phase while the influence of temperature and the addition of aqueous triethylammonium acetate buffer to the mobile phase was also innvestigated. Ferrocene ligand with Schiff-based groups have been separated satisfactorilly on BCDS column.
文摘Here we have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carrier and folic acid as a targeting ligand. Folic acid was selected as a cancer targeting ligand because folic acid receptors are highly expressed in a variety of tumor types. β-cyclodextrin and folic acid were connected through a linker [1,10-phenanthroline or 5-(hydroxymethyl) furfural]. β-cyclodextrin and folic acid were attached to the linker by formation of Schiffbase and ester, respectively. Our targeted synthetic products were confirmed by NMR, Mass and IR spectroscopy. We anticipate that our synthetic products can confer cancer cell-specific drug delivery as well as desired properties such as nanoparticle formation.
文摘Two chiral stationary phases(BCDs and YBCDs) were prepared by bonding β-cyclodextrin derivative with α-Schiff base group from β-cyclodextrin monoaldehyde to the sillica gel via 3-glyci-{dyloxypropyltrimethoxysilane} as a coupling agent. Using acetonitrile-TEAA as mobile phase, good enantiomeric resolutions were obtained for DL-aminoacide on BCDs and YBCDs, including Leucine, Threonine and Valine. It is also observed that the higher separation factor of threonine was at pH {7.11} for both of the column, and the optimal column temperatures of Leucine appeared at 30 ℃ or {40 ℃}, respectively for YBCDs and BCDs.
