Sedimentary deposits of the Lower Cretaceous Xiagou Formation form the most significant potential hydrocarbon reservoirs in the Qingxi Sag, Jiuquan Basin(NW China). Zircon U-Pb ages of the dated basalts at the top of ...Sedimentary deposits of the Lower Cretaceous Xiagou Formation form the most significant potential hydrocarbon reservoirs in the Qingxi Sag, Jiuquan Basin(NW China). Zircon U-Pb ages of the dated basalts at the top of the Xiagou Formation give an isochron age of 115.6 Ma, and the sedimentation interval of the Xiagou Formation was speculated to range from about 125/124 Ma to 115 Ma based on paleontological research and stratigraphic correlation analysis. Here we use GR logging data as a palaeoenvironmental and palaeoclimatic proxy to conduct a detailed cyclostratigraphic study of five selected wells. Power spectra, evolutionary fast Fourier transformation and wavelet analysis all reveal significant sedimentary cycles in the Xiagou Formation. The ratios of cycle wavelengths in these stratigraphic units are 33.82 m : 7.91 m : 3.06 m : 1.79 m, which is similar to the ratio of orbital targets of 20 : 5 : 2 : 1. The ratio of 20 : 5 : 2 : 1 is interpreted as Milankovitch cycles of 405 kyr long eccentricity,100 kyr short eccentricity, 37 kyr obliquity, and 22 kyr precession cycles respectively. A high-resolution astronomical time scale is constructed by tuning the stratigraphy into target curves of orbital cycles respectively. Based on the astronomical time scale, the absolute ages of 55 samples were estimated,which are used for subsequent stable carbon and oxygen isotope stratigraphy analysis. The analysis results of the five studied wells in the Qingxi Sag indicate:(1) a negative trend of δ^(13)C values upwards in the Xiagou Formation, and(2) negative δ^(18)O values with a positive trend upwards. Both relatively heavy values and pronounced covariances of δ^(13)C values and δ^(18)O values indicate an arid-evaporationcontrolled climate during the sedimentary period of the Lower Cretaceous Xiagou Formation, Qingxi Sag, Jiuquan Basin. Moreover, positive covariances of SQK_1g_(2+3) indicate extremely high temperature, and negative covariances of SQK_1g_1 indicate a relatively low temperature.展开更多
Lower Buntsandstein small—scale cycles recognized in the Central European Basin(CEB) are readily used for astrochronological calibration of the Early Triassic time scales,although they are not well studied sedimentol...Lower Buntsandstein small—scale cycles recognized in the Central European Basin(CEB) are readily used for astrochronological calibration of the Early Triassic time scales,although they are not well studied sedimentologically.Three borehole sections from the eastern part of the CEB,forming a south-north transect perpendicular to the basin axis,were studied in terms to better understand the depositional history of the Lower Buntsandstein developed as the Baltic Formation in the studied Polish part of the basin.Eleven sedimentary facies were recognized,based on lithological and sedimentological investigations of 655.7 m of drill cores from the Otyń IG 1,Gorzów Wielkopolski IG 1 and Kamień Pomorski IG 1 boreholes.The facies can be grouped according to a lithological criterion into facies of predominantly siliciclastic lithology(including 9facies types) and facies of predominantly carbonate lithology(including 2 facies types).Facies analysis allowed to distinguish 8 facies associations of:1) alluvial fan,2) playa,3) sandy-muddy coastal plain,4)embayment and distal delta,5) lagoon,6) sand bars or shoals,7) ooidal shoals or bars,and 8) offshore.Deepening-upward(DC) and shallowing-upward(SC) sedimentary cycles were recognized in parts of the Baltic Formation,with DCs dominating in the southernmost located Otyń IG 1,and SCs dominating in Gorz ow Wielkopolski IG 1,located in the axial part of the basin.Symmetrical cycles are very rare.The statistical significance of the sedimentary cycles is relatively low according to Markov-chain analysis conducted with the phpSedistat software of Stanova et al.(2009).Analysis of small—scale cycles performed on well logs of investigated boreholes and additional boreholes in the vicinity of Otyń IG 1,implementing the earlier study of Becker(2005),showed that the correlation of well-log cycles(GR cycles) and sedimentary cycles is not obvious.GR cycles can be roughly correlated with lithological carbonate—siliciclastic cycles(c-s cycles),reflecting alternations of facies groups of predominantly carbonate and siliciclastic lithology.Calibration of GR cycles to earlier magnetostratigraphic results of Nawrocki(1997) and Becker and Nawrocki(2014) showed that neither the boundaries of GR cycles serve as reference horizons,nor the cycles document equal time periods.All existing depositional models of the Lower Buntsandstein were discussed,stressing the possible simultaneous interaction of allochthonous and autochthonous processes.Moreover,the tectonic overprint of the Central European Basin system during the Early Triassic should be taken into account.The presented results suggest that the Lower Buntsandstein cyclicity of the CEB cannot serve as a basis for astrochronological analysis.展开更多
We study the limit cycle bifurcations perturbing a class of quartic linear-like Hamiltonian systems having an elementary center at the origin. First, using methods of the qualitative theory, all possible phase portrai...We study the limit cycle bifurcations perturbing a class of quartic linear-like Hamiltonian systems having an elementary center at the origin. First, using methods of the qualitative theory, all possible phase portraits of the unperturbed system are found. Then, using the first order Melnikov function, Hopf bifurcation problem of the perturbed system is investigated, and an upper bound for the function is obtained near the origin.展开更多
The simultaneity and the regionality of the chemo-cycles are proved by cycle-to-cycle correlation integrated with conodont biostratigraphic correlation of the upper part of the Givetian (Devonian) between Liujing and ...The simultaneity and the regionality of the chemo-cycles are proved by cycle-to-cycle correlation integrated with conodont biostratigraphic correlation of the upper part of the Givetian (Devonian) between Liujing and Dale. The study indicates that these chemo-cycles with time spans of 0.10 Ma have an internal relation with paleoclimatic changes, and it might have an origin through Milankovitch eccentricity cyclicity.展开更多
New conditions for a planar homoclinic loop to have cyclicity two under multiple parameter perturbations have been obtained. As an application it is proved that a homoclinic loop of a nongeneric cubic Hamiltonian has ...New conditions for a planar homoclinic loop to have cyclicity two under multiple parameter perturbations have been obtained. As an application it is proved that a homoclinic loop of a nongeneric cubic Hamiltonian has cyclicity two under arbitrary quadratic perturbations.展开更多
We establish an algebraic method and an integral method to compute the Liapunov constants and Hopf cyclicity for a general Lienard system on the plane.
This paper deals with the cyclicity of a kind of degenerate planar polycycles through a saddle-node P0 and two hyperbolic saddles P1 and P2, where the hyperbolicity ratio of the saddle P1 (which connects the saddle-no...This paper deals with the cyclicity of a kind of degenerate planar polycycles through a saddle-node P0 and two hyperbolic saddles P1 and P2, where the hyperbolicity ratio of the saddle P1 (which connects the saddle-node with hh-connection) is equal to 1 and that of the other saddle P2 is irrational. It is assumed that the connections between P0 to P2 and P0 to P1 keep unbroken. Then the cyclicity of this kind of polycycle is no more than m + 3 if the saddle P1 is of order m and the hyperbolicity ratio of P2 is bigger than m.Furthermore, the cyclicity of this polycycle is no more than 7 if the saddle P1 is of order 2 and the hyperbolicity ratio of P2 is located in the interval (1, 2).展开更多
Hydrogen energy has gained widespread recognition for its environmentally friendly nature,high energy density and abundant resources,making it a promising energy carrier for a sustainable and clean energy society.Howe...Hydrogen energy has gained widespread recognition for its environmentally friendly nature,high energy density and abundant resources,making it a promising energy carrier for a sustainable and clean energy society.However,safe and efficient hydrogen storage remains a significant challenge due to its inherent leakiness and flammability.To overcome these challenges,alloys featuring body-centered cubic(BCC)structures have emerged as compelling candidates for hydrogen storage,owing to their exceptional capacity to achieve high-density hydrogen storage up to 3.8 wt%at ambient temperatures.Nonetheless,their practical application faces limited dehydriding capacity,complex activation processes,high costs and poor cyclic stability.Various modification strategies have been explored to overcome these limitations,including lattice regulation,element substitution,rare earth doping and heat treatment.This progress report presents an overview of the previous advancements to enhance five crucial aspects(high-V,medium-V,low-V,V-free and high-entropy alloys)in composition design and hydrogen storage properties within BCC-structured alloys.Subsequently,an in-depth analysis is conducted to examine the relationship between crystal structures and hydrogen storage properties specific to BCC-structured alloys,covering aspects such as composition,crystal structure,hydrogen storage capacity,enthalpy and entropy.Furthermore,this review explores current challenges in this field and outlines directions for future research.These insights provide valuable guidance for the design of innovative and cost-effective hydrogen storage alloys.展开更多
A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that th...A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that the loading parameters(initial normal stress,normal stiffness,and shear velocity)determine propagation paths of the wing and secondary cracks in rock bridges during the initial shear cycle,creating different morphologies of macroscopic step-path rupture surfaces and asperities on them.The differences in stress state and rupture surface induce different cyclic shear responses.It shows that high initial normal stress accelerates asperity degradation,raises shear resistance,and promotes compression of intermittent joints.In addition,high normal stiffness provides higher normal stress and shear resistance during the initial cycles and inhibits the dilation and compression of intermittent joints.High shear velocity results in a higher shear resistance,greater dilation,and greater compression.Finally,shear strength is most sensitive to initial normal stress,followed by shear velocity and normal stiffness.Moreover,average dilation angle is most sensitive to initial normal stress,followed by normal stiffness and shear velocity.During the shear cycles,frictional coefficient is affected by asperity degradation,backfilling of rock debris,and frictional area,exhibiting a non-monotonic behavior.展开更多
The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enh...The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain axis.The gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine systems.Conversely,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host interactions.This reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological diseases.The coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological diseases.This study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological diseases.Recent pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional disorders.This can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage forms.These findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.展开更多
Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report...Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.展开更多
A new gold self-relay catalytic annulation/nucleophilic substitution cascade of 1,3-enyne acetates with cyclic ether acetals is reported,enabling highly diastereoselective access to cyclic etherified cyclopentenones w...A new gold self-relay catalytic annulation/nucleophilic substitution cascade of 1,3-enyne acetates with cyclic ether acetals is reported,enabling highly diastereoselective access to cyclic etherified cyclopentenones with cyclic quaternary centers in moderate to good yields and>19∶1 dr.This catalysis enables the direct construction of two types of carboncyclic skeletons by adjusting the olefin types of 1,3-enyne acetates.When 1,3-enyne acetates bearing a cyclic alkene unit were used,5~6 fused bicarbocyclic products were diastereoselectively synthesized,whereas the reaction of acyclic 1,3-enyne acetates resulted in five-memebered carbocyclic framework.Notably,cyclic ether acetals are commonly used as protecting groups in traditional multistep organic syntheses,and in this reaction,such reagents serve as electrophilic cyclic ether precursors,achieving new uses for old reagents.The current method demonstrates good functional group compatibility,a broad substrate scope and high diastereoselectivity,providing a new synthetic strategy toward functionalized cyclopentenones.展开更多
Plant roots are widely known to provide mechanical reinforcement to soils against shearing and further increase slope stability.However,whether roots provide reinforcement to loess cyclic re-sistance and how various f...Plant roots are widely known to provide mechanical reinforcement to soils against shearing and further increase slope stability.However,whether roots provide reinforcement to loess cyclic re-sistance and how various factors affect roots reinforcement during seismic loading have rarely been studied.The objective is to conduct a series of cyclic direct simple shear tests and DEM numerical simulation to investigate the cyclic behaviour of rooted loess.The effects of initial static shear stress and loading frequency on the cyclic resistance of root-soil composites were first investigated.After that,cyclic direct simple shear simulations at constant volume were carried out based on the discrete element method(PFC^(3D))to investigate the effects of root geome-try,mechanical traits and root-soil bond strength on the cyclic strength of rooted loess.It was discovered that the roots could effectively improve the cyclic resistance of loess.The cyclic resistance of the root-soil composite decreases with the increase of the initial shear stress,then increases,and improves with the increase of the frequency.The simulation result show that increases in root elastic modulus and root-soil interfacial bond strength can all enhance the cyclic resistance of root-soil composites,and the maximum cyclic resistance of the root-soil composite was obtained when the initial inclination angle of the root system was 90°.展开更多
This paper deals with the cyclicity of a kind of degenerate planar polycycles through a saddle-node and two hyperbolic saddles, where the hyperbolicity ratio of the saddle （which connects the saddle-node with hp-conn...This paper deals with the cyclicity of a kind of degenerate planar polycycles through a saddle-node and two hyperbolic saddles, where the hyperbolicity ratio of the saddle （which connects the saddle-node with hp-connection） is equal to 1 and that of the other saddle is irrational. It is obtained that the cyclicity of this kind of polycycle is no more than 5 if the hp-connection keeps unbroken under the C^∞ perturbations.展开更多
A general method for a homoclinic loop of planar Hamiltonian systems to bifurcate two or three limit cycles under perturbations is established.Certain conditions are given under which the cyclicity of a homoclinic loo...A general method for a homoclinic loop of planar Hamiltonian systems to bifurcate two or three limit cycles under perturbations is established.Certain conditions are given under which the cyclicity of a homoclinic loop equals 1 or 2.As an application to quadratic systems,it is proved that the cyclicity of homoclinic loops of quadratic in-tegrable and non-Hamiltonian systems equals 2 except for one case.展开更多
Real-time,noninvasive programmed death-ligand 1(PD-L1)testing using molecular imaging has enhanced our understanding of the immune environments of neoplasms and has served as a guide for immunotherapy.However,the util...Real-time,noninvasive programmed death-ligand 1(PD-L1)testing using molecular imaging has enhanced our understanding of the immune environments of neoplasms and has served as a guide for immunotherapy.However,the utilization of radiotracers in the imaging of human brain tumors using positron emission tomography/computed tomography(PET/CT)remains limited.This investigation involved the synthesis of[18F]AlF-NOTA-PCP2,which is a novel peptide-based radiolabeled tracer that targets PD-L1,and evaluated its imaging capabilities in orthotopic glioblastoma(GBM)models.Using this tracer,we could noninvasively monitor radiation-induced PD-L1 changes in GBM.[18F]AlF-NOTA-PCP2 exhibited high radiochemical purity(>95%)and stability up to 4 h after synthesis.It demonstrated specific,high-affinity binding to PD-L1 in vitro and in vivo,with a dissociation constant of 0.24 nM.PET/CT imaging,integrated with contrast-enhanced magnetic resonance imaging,revealed significant accumulation of[18F]AlF-NOTA-PCP2 in orthotopic tumors,correlating with blood-brain barrier disruption.After radiotherapy(15 Gy),[18F]AlF-NOTA-PCP2 uptake in tumors increased from 9.51%±0.73%to 12.04%±1.43%,indicating enhanced PD-L1 expression consistent with immunohistochemistry findings.Fractionated radiation(5 Gy×3)further amplified PD-L1 upregulation(13.9%±1.54%ID/cc)compared with a single dose(11.48%±1.05%ID/cc).Taken together,[18F]AlF-NOTA-PCP2 may be a valuable tool for noninvasively monitoring PD-L1 expression in brain tumors after radiotherapy.展开更多
This study is devoted to a novel fractional friction-damage model for quasi-brittle rock materials subjected to cyclic loadings in the framework of micromechanics.The total damage of material describing the microstruc...This study is devoted to a novel fractional friction-damage model for quasi-brittle rock materials subjected to cyclic loadings in the framework of micromechanics.The total damage of material describing the microstructural degradation is decomposed into two parts:an instantaneous part arising from monotonic loading and a fatigue-related one induced by cyclic loading,relating to the initiation and propagation of microcracks.The inelastic deformation arises directly from frictional sliding along microcracks,inherently coupled with the damage effect.A fractional plastic flow rule is introduced using stress-fractional plasticity operations and covariant transformation approach,instead of classical plastic flow function.Additionally,the progression of fatigue damage is intricately tied to subcracks and can be calculated through application of a convolution law.The number of loading cycles serves as an integration variable,establishing a connection between inelastic deformation and the evolution of fatigue damage.In order to verify the accuracy of the proposed model,comparison between analytical solutions and experimental data are carried out on three different rocks subjected to conventional triaxial compression and cyclic loading tests.The evolution of damage variables is also investigated along with the cumulative deformation and fatigue lifetime.The improvement of the fractional model is finally discussed by comparing with an existing associated fatigue model in literature.展开更多
A new cyclic prefix(CP)-based nonoverlapping FBMC-QAM(CP-NO-FBMC-QAM)system with two prototype filters is proposed in this paper,which satisfies complex orthogonality conditions and good frequency energy confinement a...A new cyclic prefix(CP)-based nonoverlapping FBMC-QAM(CP-NO-FBMC-QAM)system with two prototype filters is proposed in this paper,which satisfies complex orthogonality conditions and good frequency energy confinement at the same time.We analyze its inter-carrier interference/inter-symbol interference(ICI/ISI)over multipath channels.Owing to the additional CP,the ISI of received symbols over multipath channels is eliminated in the proposed system,and the resulting improvement in the signal-to-interference ratio(SIR)performance is evaluated by theoretical analysis.Moreover,for the ICI caused by multipath propagation in received symbols,we develop a method that eliminates the ICI by frequency-domain channel estimation and equalization before the receiver filtering process.The proposed CP-NO-FBMC-QAM system and ICI cancellation method(ICICM)are validated by comparisons of implementation complexity,power spectral density(PSD),bit error rate(BER)and channel estimation performance with conventional CP-based orthogonal frequency division multiplexing(CP-OFDM)and FBMC-QAM systems.展开更多
基金the support of a Chinese Scholarship Council’s overseas student scholarship to enable her to visit the University of Vienna for 24 monthssupported by Research Institute Exploration and Development, PetroChina Yumen Oilfield CompanyThe China National Key Research Project (No. 2017ZX05009-002-003) supported this study
文摘Sedimentary deposits of the Lower Cretaceous Xiagou Formation form the most significant potential hydrocarbon reservoirs in the Qingxi Sag, Jiuquan Basin(NW China). Zircon U-Pb ages of the dated basalts at the top of the Xiagou Formation give an isochron age of 115.6 Ma, and the sedimentation interval of the Xiagou Formation was speculated to range from about 125/124 Ma to 115 Ma based on paleontological research and stratigraphic correlation analysis. Here we use GR logging data as a palaeoenvironmental and palaeoclimatic proxy to conduct a detailed cyclostratigraphic study of five selected wells. Power spectra, evolutionary fast Fourier transformation and wavelet analysis all reveal significant sedimentary cycles in the Xiagou Formation. The ratios of cycle wavelengths in these stratigraphic units are 33.82 m : 7.91 m : 3.06 m : 1.79 m, which is similar to the ratio of orbital targets of 20 : 5 : 2 : 1. The ratio of 20 : 5 : 2 : 1 is interpreted as Milankovitch cycles of 405 kyr long eccentricity,100 kyr short eccentricity, 37 kyr obliquity, and 22 kyr precession cycles respectively. A high-resolution astronomical time scale is constructed by tuning the stratigraphy into target curves of orbital cycles respectively. Based on the astronomical time scale, the absolute ages of 55 samples were estimated,which are used for subsequent stable carbon and oxygen isotope stratigraphy analysis. The analysis results of the five studied wells in the Qingxi Sag indicate:(1) a negative trend of δ^(13)C values upwards in the Xiagou Formation, and(2) negative δ^(18)O values with a positive trend upwards. Both relatively heavy values and pronounced covariances of δ^(13)C values and δ^(18)O values indicate an arid-evaporationcontrolled climate during the sedimentary period of the Lower Cretaceous Xiagou Formation, Qingxi Sag, Jiuquan Basin. Moreover, positive covariances of SQK_1g_(2+3) indicate extremely high temperature, and negative covariances of SQK_1g_1 indicate a relatively low temperature.
基金financed from the statutory funds of the Polish Geological Institute-National Research Institute(projects No. 61.2201.0605.00.0 and No.62.9012.2034.00.0)。
文摘Lower Buntsandstein small—scale cycles recognized in the Central European Basin(CEB) are readily used for astrochronological calibration of the Early Triassic time scales,although they are not well studied sedimentologically.Three borehole sections from the eastern part of the CEB,forming a south-north transect perpendicular to the basin axis,were studied in terms to better understand the depositional history of the Lower Buntsandstein developed as the Baltic Formation in the studied Polish part of the basin.Eleven sedimentary facies were recognized,based on lithological and sedimentological investigations of 655.7 m of drill cores from the Otyń IG 1,Gorzów Wielkopolski IG 1 and Kamień Pomorski IG 1 boreholes.The facies can be grouped according to a lithological criterion into facies of predominantly siliciclastic lithology(including 9facies types) and facies of predominantly carbonate lithology(including 2 facies types).Facies analysis allowed to distinguish 8 facies associations of:1) alluvial fan,2) playa,3) sandy-muddy coastal plain,4)embayment and distal delta,5) lagoon,6) sand bars or shoals,7) ooidal shoals or bars,and 8) offshore.Deepening-upward(DC) and shallowing-upward(SC) sedimentary cycles were recognized in parts of the Baltic Formation,with DCs dominating in the southernmost located Otyń IG 1,and SCs dominating in Gorz ow Wielkopolski IG 1,located in the axial part of the basin.Symmetrical cycles are very rare.The statistical significance of the sedimentary cycles is relatively low according to Markov-chain analysis conducted with the phpSedistat software of Stanova et al.(2009).Analysis of small—scale cycles performed on well logs of investigated boreholes and additional boreholes in the vicinity of Otyń IG 1,implementing the earlier study of Becker(2005),showed that the correlation of well-log cycles(GR cycles) and sedimentary cycles is not obvious.GR cycles can be roughly correlated with lithological carbonate—siliciclastic cycles(c-s cycles),reflecting alternations of facies groups of predominantly carbonate and siliciclastic lithology.Calibration of GR cycles to earlier magnetostratigraphic results of Nawrocki(1997) and Becker and Nawrocki(2014) showed that neither the boundaries of GR cycles serve as reference horizons,nor the cycles document equal time periods.All existing depositional models of the Lower Buntsandstein were discussed,stressing the possible simultaneous interaction of allochthonous and autochthonous processes.Moreover,the tectonic overprint of the Central European Basin system during the Early Triassic should be taken into account.The presented results suggest that the Lower Buntsandstein cyclicity of the CEB cannot serve as a basis for astrochronological analysis.
基金supported by the National Natural Science Foundations of China(12371171)and the Natural Science Foundation of Jiangsu Province(BK20221339).
文摘We study the limit cycle bifurcations perturbing a class of quartic linear-like Hamiltonian systems having an elementary center at the origin. First, using methods of the qualitative theory, all possible phase portraits of the unperturbed system are found. Then, using the first order Melnikov function, Hopf bifurcation problem of the perturbed system is investigated, and an upper bound for the function is obtained near the origin.
文摘The simultaneity and the regionality of the chemo-cycles are proved by cycle-to-cycle correlation integrated with conodont biostratigraphic correlation of the upper part of the Givetian (Devonian) between Liujing and Dale. The study indicates that these chemo-cycles with time spans of 0.10 Ma have an internal relation with paleoclimatic changes, and it might have an origin through Milankovitch eccentricity cyclicity.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 19531070 and 19771037)
文摘New conditions for a planar homoclinic loop to have cyclicity two under multiple parameter perturbations have been obtained. As an application it is proved that a homoclinic loop of a nongeneric cubic Hamiltonian has cyclicity two under arbitrary quadratic perturbations.
文摘We establish an algebraic method and an integral method to compute the Liapunov constants and Hopf cyclicity for a general Lienard system on the plane.
基金This work was supported by the National Natural Science Foundation of China(Grant No.19901001).
文摘This paper deals with the cyclicity of a kind of degenerate planar polycycles through a saddle-node P0 and two hyperbolic saddles P1 and P2, where the hyperbolicity ratio of the saddle P1 (which connects the saddle-node with hh-connection) is equal to 1 and that of the other saddle P2 is irrational. It is assumed that the connections between P0 to P2 and P0 to P1 keep unbroken. Then the cyclicity of this kind of polycycle is no more than m + 3 if the saddle P1 is of order m and the hyperbolicity ratio of P2 is bigger than m.Furthermore, the cyclicity of this polycycle is no more than 7 if the saddle P1 is of order 2 and the hyperbolicity ratio of P2 is located in the interval (1, 2).
基金supported by the National Key R&D Program of China(No.2022YFB3504700)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA0400304)the Research Fund of Key Laboratory of Rare Earths,Chinese Academy of Sciences(No.E32PF00116).
文摘Hydrogen energy has gained widespread recognition for its environmentally friendly nature,high energy density and abundant resources,making it a promising energy carrier for a sustainable and clean energy society.However,safe and efficient hydrogen storage remains a significant challenge due to its inherent leakiness and flammability.To overcome these challenges,alloys featuring body-centered cubic(BCC)structures have emerged as compelling candidates for hydrogen storage,owing to their exceptional capacity to achieve high-density hydrogen storage up to 3.8 wt%at ambient temperatures.Nonetheless,their practical application faces limited dehydriding capacity,complex activation processes,high costs and poor cyclic stability.Various modification strategies have been explored to overcome these limitations,including lattice regulation,element substitution,rare earth doping and heat treatment.This progress report presents an overview of the previous advancements to enhance five crucial aspects(high-V,medium-V,low-V,V-free and high-entropy alloys)in composition design and hydrogen storage properties within BCC-structured alloys.Subsequently,an in-depth analysis is conducted to examine the relationship between crystal structures and hydrogen storage properties specific to BCC-structured alloys,covering aspects such as composition,crystal structure,hydrogen storage capacity,enthalpy and entropy.Furthermore,this review explores current challenges in this field and outlines directions for future research.These insights provide valuable guidance for the design of innovative and cost-effective hydrogen storage alloys.
基金financially supported by the National Natural Science Foundation of China(Grant No.42172292)Taishan Scholars Project Special Funding,and Shandong Energy Group(Grant No.SNKJ 2022A01-R26).
文摘A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that the loading parameters(initial normal stress,normal stiffness,and shear velocity)determine propagation paths of the wing and secondary cracks in rock bridges during the initial shear cycle,creating different morphologies of macroscopic step-path rupture surfaces and asperities on them.The differences in stress state and rupture surface induce different cyclic shear responses.It shows that high initial normal stress accelerates asperity degradation,raises shear resistance,and promotes compression of intermittent joints.In addition,high normal stiffness provides higher normal stress and shear resistance during the initial cycles and inhibits the dilation and compression of intermittent joints.High shear velocity results in a higher shear resistance,greater dilation,and greater compression.Finally,shear strength is most sensitive to initial normal stress,followed by shear velocity and normal stiffness.Moreover,average dilation angle is most sensitive to initial normal stress,followed by normal stiffness and shear velocity.During the shear cycles,frictional coefficient is affected by asperity degradation,backfilling of rock debris,and frictional area,exhibiting a non-monotonic behavior.
基金supported by the National Natural Science Foundation of China,No.82003965the Science and Technology Research Project of Sichuan Provincial Administration of Traditional Chinese Medicine,No.2024MS167(to LH)+2 种基金the Xinglin Scholar Program of Chengdu University of Traditional Chinese Medicine,No.QJRC2022033(to LH)the Improvement Plan for the'Xinglin Scholar'Scientific Research Talent Program at Chengdu University of Traditional Chinese Medicine,No.XKTD2023002(to LH)the 2023 National Project of the College Students'Innovation and Entrepreneurship Training Program at Chengdu University of Traditional Chinese Medicine,No.202310633028(to FD)。
文摘The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain axis.The gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine systems.Conversely,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host interactions.This reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological diseases.The coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological diseases.This study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological diseases.Recent pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional disorders.This can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage forms.These findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.
基金supported by the National Natural Science Foundation of China,Nos.82171429,81771384a grant from Wuxi Municipal Health Commission,No.1286010241190480(all to YS)。
文摘Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.
文摘A new gold self-relay catalytic annulation/nucleophilic substitution cascade of 1,3-enyne acetates with cyclic ether acetals is reported,enabling highly diastereoselective access to cyclic etherified cyclopentenones with cyclic quaternary centers in moderate to good yields and>19∶1 dr.This catalysis enables the direct construction of two types of carboncyclic skeletons by adjusting the olefin types of 1,3-enyne acetates.When 1,3-enyne acetates bearing a cyclic alkene unit were used,5~6 fused bicarbocyclic products were diastereoselectively synthesized,whereas the reaction of acyclic 1,3-enyne acetates resulted in five-memebered carbocyclic framework.Notably,cyclic ether acetals are commonly used as protecting groups in traditional multistep organic syntheses,and in this reaction,such reagents serve as electrophilic cyclic ether precursors,achieving new uses for old reagents.The current method demonstrates good functional group compatibility,a broad substrate scope and high diastereoselectivity,providing a new synthetic strategy toward functionalized cyclopentenones.
文摘Plant roots are widely known to provide mechanical reinforcement to soils against shearing and further increase slope stability.However,whether roots provide reinforcement to loess cyclic re-sistance and how various factors affect roots reinforcement during seismic loading have rarely been studied.The objective is to conduct a series of cyclic direct simple shear tests and DEM numerical simulation to investigate the cyclic behaviour of rooted loess.The effects of initial static shear stress and loading frequency on the cyclic resistance of root-soil composites were first investigated.After that,cyclic direct simple shear simulations at constant volume were carried out based on the discrete element method(PFC^(3D))to investigate the effects of root geome-try,mechanical traits and root-soil bond strength on the cyclic strength of rooted loess.It was discovered that the roots could effectively improve the cyclic resistance of loess.The cyclic resistance of the root-soil composite decreases with the increase of the initial shear stress,then increases,and improves with the increase of the frequency.The simulation result show that increases in root elastic modulus and root-soil interfacial bond strength can all enhance the cyclic resistance of root-soil composites,and the maximum cyclic resistance of the root-soil composite was obtained when the initial inclination angle of the root system was 90°.
基金Project sponsored by National Science Foundation (19901001)
文摘This paper deals with the cyclicity of a kind of degenerate planar polycycles through a saddle-node and two hyperbolic saddles, where the hyperbolicity ratio of the saddle （which connects the saddle-node with hp-connection） is equal to 1 and that of the other saddle is irrational. It is obtained that the cyclicity of this kind of polycycle is no more than 5 if the hp-connection keeps unbroken under the C^∞ perturbations.
基金Project supported by the National Natural Science Foundation of China.
文摘A general method for a homoclinic loop of planar Hamiltonian systems to bifurcate two or three limit cycles under perturbations is established.Certain conditions are given under which the cyclicity of a homoclinic loop equals 1 or 2.As an application to quadratic systems,it is proved that the cyclicity of homoclinic loops of quadratic in-tegrable and non-Hamiltonian systems equals 2 except for one case.
基金support from the National Natural Science Foundation of China(Grant Nos.:82272751 and 82202958)the Natural Science Foundation of Shandong,China(Grant No.:ZR2021LSW002)+6 种基金the Science and Technology Program of Jinan,China(Grant Nos.:202225019 and 202225013)to Man Huthe Shandong Postdoctoral Innovation Program,China(Grant No.:SDCX-ZG-202302011)Beijing Science and Technology Innovation Medical Development Foundation,China(Grant No.:KC2023-JX-0288-BQ26)to Yong Wangthe Natural Science Foundation of China(Grant No.:NSFC82303676)the Natural Science Foundation of Shandong(Grant No.:ZR2023QH208)the China Postdoctoral Science Foundation(Grant No.:2023M732125)the Taishan Scholar Project Special Fund(Grant No.:tsqn202312368)to Kewen He.
文摘Real-time,noninvasive programmed death-ligand 1(PD-L1)testing using molecular imaging has enhanced our understanding of the immune environments of neoplasms and has served as a guide for immunotherapy.However,the utilization of radiotracers in the imaging of human brain tumors using positron emission tomography/computed tomography(PET/CT)remains limited.This investigation involved the synthesis of[18F]AlF-NOTA-PCP2,which is a novel peptide-based radiolabeled tracer that targets PD-L1,and evaluated its imaging capabilities in orthotopic glioblastoma(GBM)models.Using this tracer,we could noninvasively monitor radiation-induced PD-L1 changes in GBM.[18F]AlF-NOTA-PCP2 exhibited high radiochemical purity(>95%)and stability up to 4 h after synthesis.It demonstrated specific,high-affinity binding to PD-L1 in vitro and in vivo,with a dissociation constant of 0.24 nM.PET/CT imaging,integrated with contrast-enhanced magnetic resonance imaging,revealed significant accumulation of[18F]AlF-NOTA-PCP2 in orthotopic tumors,correlating with blood-brain barrier disruption.After radiotherapy(15 Gy),[18F]AlF-NOTA-PCP2 uptake in tumors increased from 9.51%±0.73%to 12.04%±1.43%,indicating enhanced PD-L1 expression consistent with immunohistochemistry findings.Fractionated radiation(5 Gy×3)further amplified PD-L1 upregulation(13.9%±1.54%ID/cc)compared with a single dose(11.48%±1.05%ID/cc).Taken together,[18F]AlF-NOTA-PCP2 may be a valuable tool for noninvasively monitoring PD-L1 expression in brain tumors after radiotherapy.
基金Fundamental Research Funds for the Central Universities(Grant No.B230201059)for the support.
文摘This study is devoted to a novel fractional friction-damage model for quasi-brittle rock materials subjected to cyclic loadings in the framework of micromechanics.The total damage of material describing the microstructural degradation is decomposed into two parts:an instantaneous part arising from monotonic loading and a fatigue-related one induced by cyclic loading,relating to the initiation and propagation of microcracks.The inelastic deformation arises directly from frictional sliding along microcracks,inherently coupled with the damage effect.A fractional plastic flow rule is introduced using stress-fractional plasticity operations and covariant transformation approach,instead of classical plastic flow function.Additionally,the progression of fatigue damage is intricately tied to subcracks and can be calculated through application of a convolution law.The number of loading cycles serves as an integration variable,establishing a connection between inelastic deformation and the evolution of fatigue damage.In order to verify the accuracy of the proposed model,comparison between analytical solutions and experimental data are carried out on three different rocks subjected to conventional triaxial compression and cyclic loading tests.The evolution of damage variables is also investigated along with the cumulative deformation and fatigue lifetime.The improvement of the fractional model is finally discussed by comparing with an existing associated fatigue model in literature.
文摘A new cyclic prefix(CP)-based nonoverlapping FBMC-QAM(CP-NO-FBMC-QAM)system with two prototype filters is proposed in this paper,which satisfies complex orthogonality conditions and good frequency energy confinement at the same time.We analyze its inter-carrier interference/inter-symbol interference(ICI/ISI)over multipath channels.Owing to the additional CP,the ISI of received symbols over multipath channels is eliminated in the proposed system,and the resulting improvement in the signal-to-interference ratio(SIR)performance is evaluated by theoretical analysis.Moreover,for the ICI caused by multipath propagation in received symbols,we develop a method that eliminates the ICI by frequency-domain channel estimation and equalization before the receiver filtering process.The proposed CP-NO-FBMC-QAM system and ICI cancellation method(ICICM)are validated by comparisons of implementation complexity,power spectral density(PSD),bit error rate(BER)and channel estimation performance with conventional CP-based orthogonal frequency division multiplexing(CP-OFDM)and FBMC-QAM systems.
