This paper presents an overview of the recent developments in hybrid wind-wave energy.With the focus on floating concepts,the possible configurations introduced in the literature are categorized and depicted,and the m...This paper presents an overview of the recent developments in hybrid wind-wave energy.With the focus on floating concepts,the possible configurations introduced in the literature are categorized and depicted,and the main conclusions obtained from the references are summarized.Moreover,offshore wind and wave resources are discussed in terms of complementarity and supplementarity,offering a new perspective to developing hybrid wind-wave energy systems that look for synergies not limited to maximizing power output.Then,the feasibility of the concepts under development is discussed in detail,with focus on technical feasibility,dynamic feasibility and limitations of the methods employed.The hybrid configurations that surpassed the experimental validation phase are highlighted,and the experimental results are summarized.By compiling more than 40 floating wind turbine concepts,new relations are drawn between power,wind turbine dimensions,platforms’draft and displacement,which are further related to the payload allowance of the units to accommodate wave devices and onboard power take-off systems.Bearing in mind that it is a challenge to model the exact dynamics of hybrid floating wind-wave platforms,this paper elucidates the current research gaps,limitations and future trends in the field.Lastly,based on the overview and topics discussed,several major conclusions are drawn concerning hybrid synergies,dynamics and hydrodynamics of hybrid platforms,feasibility of concepts,among other regards.展开更多
Thermal runaway(TR)in lithium-ion batteries(LIBs)poses significant safety risks due to its potential to trigger fires and explosions.Early warning of battery TR through gas sensing has emerged as a promising strategy ...Thermal runaway(TR)in lithium-ion batteries(LIBs)poses significant safety risks due to its potential to trigger fires and explosions.Early warning of battery TR through gas sensing has emerged as a promising strategy for hazard mitigation.However,comprehensive reviews critically summarizing recent progress in advanced gas sensing technologies remain scarce.To fill this void,we present a critical review consolidating state-of-the-art advancements in gas sensing for TR early warning.This review first overviews the fundamentals of gas sensing for TR monitoring,encompassing thermodynamics and kinetic principles of gas evolution alongside current gas sensing technologies.We then comprehensively explored multi-scale engineering methods,spanning material innovations,device configurations,and system-level integration,with an emphasis on cutting-edge techniques like additive manufacturing and data-driven design frameworks.Future research priorities are identified,including the enhancement of gas selectivity and environmental robustness,the development of machine learning-driven intelligent gas sensing networks,and the establishment of standardized protocols for practical deployment.By integrating interdisciplinary insights derived from materials science,electrochemistry,and embedded systems engineering,this review is positioned to offer actionable guidelines for advancing scalable and reliable gas-sensing solutions toward boosted LIB safety.展开更多
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul...The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.展开更多
The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to ...The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to more than 30% of the world's population,predominantly in developing countries where per capita farmland and food supply are only 40% of those in developed nations(FAO 2018).Meeting the Zero Hunger target amid ongoing population growth in these regions requires a substantial increase in agricultural production while minimizing soil degradation and adverse ecological impacts.This challenge is shared by many countries across South Asia,Africa,and Central and South America.展开更多
Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊...Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。展开更多
Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.You...Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization.展开更多
China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions and,in turn,influences many aspects of wider economic and social developme...County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions and,in turn,influences many aspects of wider economic and social development.In China's modernization process,they have always played a vital role.The 2024 Central Economic Work Conference placed strong emphasis on vigorously developing county economies.展开更多
1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconn...1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconnected social,economic,and environmental targets.展开更多
To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction fou...To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction four times successively and the Technical Guidelines for Intelligent Construction(Trial).展开更多
China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have alwa...China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.展开更多
Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th...Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.展开更多
Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications i...Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.展开更多
The 20th Communist Party of China(CPC)Central Committee held its fourth plenary session in Beijing on October 20-23.The plenary session's central task was to deliberate on the framework of the country's next n...The 20th Communist Party of China(CPC)Central Committee held its fourth plenary session in Beijing on October 20-23.The plenary session's central task was to deliberate on the framework of the country's next national development roadmap:the 15th Five-Year Plan(2026-2030).Every five-year plan is important but this one arrives at a truly pivotal moment in terms of China's development trajectory and the global environment.展开更多
Arbitration is a key non-litigation commercial mechanism for the resolution of disputes, and the quality and credibility of its awards depend largely on the competency of the arbitrators. However, the selection and ev...Arbitration is a key non-litigation commercial mechanism for the resolution of disputes, and the quality and credibility of its awards depend largely on the competency of the arbitrators. However, the selection and evaluation systems for arbitrators in China have long faced challenges such as the vague criteria for competency and an unclear professionalization path for arbitrators. To address these issues, this study is grounded in the context of actual Chinese arbitration practice and based on the competency iceberg model. Through a methodological approach encompassing literature reviews, behavioral event interviews, expert revisions, and questionnaire surveys, a Chinese Arbitrator Competency Scale was developed and validated in this study. Examination of the findings indicated that the scale needed to consist of five dimensions—communication and coordination, cognitive skills, ethical conduct, work motivation, and personality traits—and possess a total of 28 specific indicators. Confirmatory analysis of the factors demonstrates a good fit for the five-dimensional model, with each of the dimensions exhibiting high reliability and validity. This scale is innovative in integrating the competency elements with Chinese characteristics, such as commercial acumen, crosscultural mediation skills, and adaptability to the local rule of law. This research not only enriches the competency theory in regard to the field of human resource management but also provides a scientific framework of standards and measurement tools for the selection, training, and evaluation of arbitrators. It thus has significant practical value for enhancing the professionalism and international competitiveness of China's arbitration system.展开更多
The development of skeletal muscle are complicated processes involving genes responsible for proper muscle morphology,contractility,cell proliferation,differentiation,interactions,migration,and death.The three-dimensi...The development of skeletal muscle are complicated processes involving genes responsible for proper muscle morphology,contractility,cell proliferation,differentiation,interactions,migration,and death.The three-dimensional chromatin architecture of skeletal muscle development has not been studied intensively although dynamic transcriptional regulation during differentiation of muscle cells is one of the most deeply studied processes.The RNA-seq was used to analyze the transcriptome pattern during chicken muscle development across 12 stages.Hi-C was used to build chromatin architectures during four representative stages.Ch IP-seq was conducted to identify enhancers and promoters in these four stages,which are occupied by histone H3K27ac and H3K4me3 peaks.Results show that large-scale genome architecture changes are mostly unidirectional,and coupled by complex on/off dynamic patterns of gene expression.Specifically,we observed 258.30 Mb of the genome undergoing A/B compartment switching.Notable alterations(316.57 Mb)of interaction frequencies within TADs were observed.Substantial aging-associated genes exhibited ascending connectivity with the compartment transition from repressive to active status during muscle development.Some muscle-related gene promoters that interacted with active enhancers during development,and some myopathy/aging-associated genes that were activated in aging muscle were founded.These results provide key insights into skeletal muscle development in vivo,and offer a valuable resource that allows in-depth functional characterization of candidate genes.展开更多
Against the backdrop of China s accelerated green development and its pursuit of the"dual carbon"goals,green finance,as a crucial instrument for the rational allocation of resources,plays a significant role ...Against the backdrop of China s accelerated green development and its pursuit of the"dual carbon"goals,green finance,as a crucial instrument for the rational allocation of resources,plays a significant role in promoting agricultural green transformation.Taking Henan Province as a case study,this research employs panel data from 18 prefecture-level cities spanning 2014 to 2023,utilizing dynamic panel models and mediating effect models for empirical analysis.The findings reveal that green finance indirectly fosters agricultural green development by driving agricultural technological progress.This promoting effect is significant,with the mediating effect accounting for 3.67%.Based on these results,policy recommendations are proposed:expanding the coverage of green finance and constructing a diversified product system;comprehensively promoting agricultural technological innovation and mechanization development;and coordinating and integrating green financial resources to facilitate agricultural green transformation tailored to local conditions.展开更多
The International Standardization Youth Star Competition is held for three consecutive years.We have witnessed continuous improvement in the competition each year,which is a result of our collective efforts.
N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While...N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While the importance of m^(6)A modification in various biological processes has been recognized,a comprehensive understanding of its diverse roles in plant biology and agricultural applications remains fragmented.This review analyzes recent advances inm^(6)A modification's biological functions in plants.m^(6)A modification plays crucial roles in multiple aspects of plant life,including seed germination,organ development,and reproductive structure formation.Furthermore,m^(6)A has been found to significantly influence plant responses to environmental stresses,including salt,drought,temperature,and heavy metal exposure.We also uncover m^(6)A involvement in important agricultural traits.This review provides insights into the mechanistic understanding of m^(6)A modification in plants and highlights its applications in agricultural improvement,offering a foundation for future research in crop enhancement and stress resistance.展开更多
The dawn in Gyirong arrives softly,as golden light spills across snow-capped peaks and filters down into the deep valleys.In Jifu Village,nestled along the Gyirong Zangbo River,the morning air is always moist,carrying...The dawn in Gyirong arrives softly,as golden light spills across snow-capped peaks and filters down into the deep valleys.In Jifu Village,nestled along the Gyirong Zangbo River,the morning air is always moist,carrying the fragrance of water and soil.For centuries,this Chinese border village near Nepal has been a crossroad of cultures.It was here,in 1994,that a girl named Langsa was bom as the eldest of five siblings.展开更多
基金supported by the Portuguese Foundation for Science and Technology(Fundação para a Ciência e Tecnologia-FCT)it contributes to the Strategic Research Plan of the Centre for Marine Technology and Ocean Engineering(Grant No.UIDB/UIDP/00134/2020)funded the first author for his PhD Scholarship(Grant No.SFRH/BD/145602/2019).
文摘This paper presents an overview of the recent developments in hybrid wind-wave energy.With the focus on floating concepts,the possible configurations introduced in the literature are categorized and depicted,and the main conclusions obtained from the references are summarized.Moreover,offshore wind and wave resources are discussed in terms of complementarity and supplementarity,offering a new perspective to developing hybrid wind-wave energy systems that look for synergies not limited to maximizing power output.Then,the feasibility of the concepts under development is discussed in detail,with focus on technical feasibility,dynamic feasibility and limitations of the methods employed.The hybrid configurations that surpassed the experimental validation phase are highlighted,and the experimental results are summarized.By compiling more than 40 floating wind turbine concepts,new relations are drawn between power,wind turbine dimensions,platforms’draft and displacement,which are further related to the payload allowance of the units to accommodate wave devices and onboard power take-off systems.Bearing in mind that it is a challenge to model the exact dynamics of hybrid floating wind-wave platforms,this paper elucidates the current research gaps,limitations and future trends in the field.Lastly,based on the overview and topics discussed,several major conclusions are drawn concerning hybrid synergies,dynamics and hydrodynamics of hybrid platforms,feasibility of concepts,among other regards.
基金financial support from the National Natural Science Foundation of China(Nos.52325801,52402052)。
文摘Thermal runaway(TR)in lithium-ion batteries(LIBs)poses significant safety risks due to its potential to trigger fires and explosions.Early warning of battery TR through gas sensing has emerged as a promising strategy for hazard mitigation.However,comprehensive reviews critically summarizing recent progress in advanced gas sensing technologies remain scarce.To fill this void,we present a critical review consolidating state-of-the-art advancements in gas sensing for TR early warning.This review first overviews the fundamentals of gas sensing for TR monitoring,encompassing thermodynamics and kinetic principles of gas evolution alongside current gas sensing technologies.We then comprehensively explored multi-scale engineering methods,spanning material innovations,device configurations,and system-level integration,with an emphasis on cutting-edge techniques like additive manufacturing and data-driven design frameworks.Future research priorities are identified,including the enhancement of gas selectivity and environmental robustness,the development of machine learning-driven intelligent gas sensing networks,and the establishment of standardized protocols for practical deployment.By integrating interdisciplinary insights derived from materials science,electrochemistry,and embedded systems engineering,this review is positioned to offer actionable guidelines for advancing scalable and reliable gas-sensing solutions toward boosted LIB safety.
基金supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
文摘The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
文摘The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to more than 30% of the world's population,predominantly in developing countries where per capita farmland and food supply are only 40% of those in developed nations(FAO 2018).Meeting the Zero Hunger target amid ongoing population growth in these regions requires a substantial increase in agricultural production while minimizing soil degradation and adverse ecological impacts.This challenge is shared by many countries across South Asia,Africa,and Central and South America.
文摘Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。
文摘Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization.
文摘China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
文摘County economies form a distinctive,integrated regional economic structure.Their growth is shaped by specific social and historical conditions and,in turn,influences many aspects of wider economic and social development.In China's modernization process,they have always played a vital role.The 2024 Central Economic Work Conference placed strong emphasis on vigorously developing county economies.
文摘1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconnected social,economic,and environmental targets.
文摘To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction four times successively and the Technical Guidelines for Intelligent Construction(Trial).
文摘China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.
文摘Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.
基金supported by the National Natural Science Foundation of China(Grant No.32160172)the Key Science-Technology Project of Inner Mongolia(2023KYPT0010)+1 种基金the Natural Science Foundation of Inner Mongolia Autonomous Region of China(Grant No.2025QN03006)the 2023 Inner Mongolia Public Institution High-Level Talent Introduction Scientific Research Support Project.
文摘Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.
文摘The 20th Communist Party of China(CPC)Central Committee held its fourth plenary session in Beijing on October 20-23.The plenary session's central task was to deliberate on the framework of the country's next national development roadmap:the 15th Five-Year Plan(2026-2030).Every five-year plan is important but this one arrives at a truly pivotal moment in terms of China's development trajectory and the global environment.
基金Research on Problems and Countermeasures in Building the Capacity of the Grassroots International Chambers of Commerce in the Context of High-Quality Development (W2024H03841)a key research project of the China Council for the Promotion of International Trade in 2025。
文摘Arbitration is a key non-litigation commercial mechanism for the resolution of disputes, and the quality and credibility of its awards depend largely on the competency of the arbitrators. However, the selection and evaluation systems for arbitrators in China have long faced challenges such as the vague criteria for competency and an unclear professionalization path for arbitrators. To address these issues, this study is grounded in the context of actual Chinese arbitration practice and based on the competency iceberg model. Through a methodological approach encompassing literature reviews, behavioral event interviews, expert revisions, and questionnaire surveys, a Chinese Arbitrator Competency Scale was developed and validated in this study. Examination of the findings indicated that the scale needed to consist of five dimensions—communication and coordination, cognitive skills, ethical conduct, work motivation, and personality traits—and possess a total of 28 specific indicators. Confirmatory analysis of the factors demonstrates a good fit for the five-dimensional model, with each of the dimensions exhibiting high reliability and validity. This scale is innovative in integrating the competency elements with Chinese characteristics, such as commercial acumen, crosscultural mediation skills, and adaptability to the local rule of law. This research not only enriches the competency theory in regard to the field of human resource management but also provides a scientific framework of standards and measurement tools for the selection, training, and evaluation of arbitrators. It thus has significant practical value for enhancing the professionalism and international competitiveness of China's arbitration system.
基金supported by the National Key R&D Program of China(2023YFD1300040 and 2022YFF1000100)the Sichuan Science and Technology Program,China(2022NSFSC0132,2021YFYZ0009 and 2022JDJQ0054)the National Natural Science Foundation of China(32225046)。
文摘The development of skeletal muscle are complicated processes involving genes responsible for proper muscle morphology,contractility,cell proliferation,differentiation,interactions,migration,and death.The three-dimensional chromatin architecture of skeletal muscle development has not been studied intensively although dynamic transcriptional regulation during differentiation of muscle cells is one of the most deeply studied processes.The RNA-seq was used to analyze the transcriptome pattern during chicken muscle development across 12 stages.Hi-C was used to build chromatin architectures during four representative stages.Ch IP-seq was conducted to identify enhancers and promoters in these four stages,which are occupied by histone H3K27ac and H3K4me3 peaks.Results show that large-scale genome architecture changes are mostly unidirectional,and coupled by complex on/off dynamic patterns of gene expression.Specifically,we observed 258.30 Mb of the genome undergoing A/B compartment switching.Notable alterations(316.57 Mb)of interaction frequencies within TADs were observed.Substantial aging-associated genes exhibited ascending connectivity with the compartment transition from repressive to active status during muscle development.Some muscle-related gene promoters that interacted with active enhancers during development,and some myopathy/aging-associated genes that were activated in aging muscle were founded.These results provide key insights into skeletal muscle development in vivo,and offer a valuable resource that allows in-depth functional characterization of candidate genes.
基金Supported by Zhejiang Provincial Philosophy and Social Sciences Planning Project(23FNSQ58YB).
文摘Against the backdrop of China s accelerated green development and its pursuit of the"dual carbon"goals,green finance,as a crucial instrument for the rational allocation of resources,plays a significant role in promoting agricultural green transformation.Taking Henan Province as a case study,this research employs panel data from 18 prefecture-level cities spanning 2014 to 2023,utilizing dynamic panel models and mediating effect models for empirical analysis.The findings reveal that green finance indirectly fosters agricultural green development by driving agricultural technological progress.This promoting effect is significant,with the mediating effect accounting for 3.67%.Based on these results,policy recommendations are proposed:expanding the coverage of green finance and constructing a diversified product system;comprehensively promoting agricultural technological innovation and mechanization development;and coordinating and integrating green financial resources to facilitate agricultural green transformation tailored to local conditions.
文摘The International Standardization Youth Star Competition is held for three consecutive years.We have witnessed continuous improvement in the competition each year,which is a result of our collective efforts.
基金supported by the National Nature Science Foundation of China(Grant No.31660568)Guangxi Science and Technology major project(Grant No.GuikeAA22068088)+2 种基金start-up funding for introduced talents in Guangxi University,the Guangxi Colleges and Universities Young and Middle-aged Teachers'Basic Scientific Research Ability Improvement Project(Grant No.2024KY0010)Guangxi Graduate Education Innovation Program(Grant No.YCSW2024093)the Guangxi University Student Innovation and Entrepreneurship Training Program Funding Project(Grant Nos.202310593704,202310593714,202410953044S).
文摘N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While the importance of m^(6)A modification in various biological processes has been recognized,a comprehensive understanding of its diverse roles in plant biology and agricultural applications remains fragmented.This review analyzes recent advances inm^(6)A modification's biological functions in plants.m^(6)A modification plays crucial roles in multiple aspects of plant life,including seed germination,organ development,and reproductive structure formation.Furthermore,m^(6)A has been found to significantly influence plant responses to environmental stresses,including salt,drought,temperature,and heavy metal exposure.We also uncover m^(6)A involvement in important agricultural traits.This review provides insights into the mechanistic understanding of m^(6)A modification in plants and highlights its applications in agricultural improvement,offering a foundation for future research in crop enhancement and stress resistance.
文摘The dawn in Gyirong arrives softly,as golden light spills across snow-capped peaks and filters down into the deep valleys.In Jifu Village,nestled along the Gyirong Zangbo River,the morning air is always moist,carrying the fragrance of water and soil.For centuries,this Chinese border village near Nepal has been a crossroad of cultures.It was here,in 1994,that a girl named Langsa was bom as the eldest of five siblings.
