Protective hardware is essential for mitigating damage caused by unavoidable falls in humanoid robots.Despite notable progress in fall protection hardware,the theoretical foundation for modeling and the feasibility of...Protective hardware is essential for mitigating damage caused by unavoidable falls in humanoid robots.Despite notable progress in fall protection hardware,the theoretical foundation for modeling and the feasibility of conducting full-scale fall experiments on robots or their surrogates remain somewhat limited.This paper proposes a method for optimizing the thickness of Expandable Polyethylene(EPE),which is used as back protection for the Chubao humanoid robot,based on small-scale impact test data to predict full-scale behavior.The optimal thickness is defined as a balance between compact design and protective effectiveness.An equivalent impact model characterized by four parameters:contact area S,mass m,fall height h,and cushioning material thickness d is introduced to describe impact conditions.The relationship between the peak impact acceleration ap and material thickness d,which forms the core of the method and gives rise to the name AP-D,is analyzed through their plotted curves.After introducing three characteristic parameters and two correction fac-tors,the relationship among the aforementioned variables is derived.Subsequently,both the optimal thickness do and its corresponding peak impact acceleration aop are predicted via nonlinear and linear regression models.Finally,the accuracy and effectiveness of the theoretically derived optimal thickness are validated on both a dummy and the actual robot.With the cushioning material applied,the peak chest acceleration is reduced to 41.57g for the dummy and 32.08g for the robot.展开更多
This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock fragmentation.It involves analyses of the evolution patterns ...This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock fragmentation.It involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the specimens.First,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock mass.The experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock mass.Subsequently,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion layers.The numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock mass.This illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.展开更多
The supply of energy is a severe challenge for every country,particularly those that are industrially developed and highly populated.Natural gas is among the most essential energy sources due to its reasonably low cos...The supply of energy is a severe challenge for every country,particularly those that are industrially developed and highly populated.Natural gas is among the most essential energy sources due to its reasonably low cost and high heating value.One of the elements of a sustainable energy supply is underground gas storage(UGS).UGS systems consist of a cushion gas(base gas)and a working gas.The cushion gas is injected into a reservoir to sustain the pressure and remain there until the period of storage ends,while the working gas is the main gas to be stored and produced.Unlike prior studies on fully depleted fields,our research emphasizes the potential of UGS in the presence of remaining oil and integrates key concepts,such as enhanced oil recovery and CO_(2)sequestration.A simulation study was conducted using Qatari Advanced Simulator for Reservoirs software to determine the feasibility of a UGS system in a partially depleted oil reservoir.N_(2) and CO_(2)gases were considered and analyzed over short,medium,and long injection/withdrawal cycles to investigate their potential as cushion gases for natural gas storage in a partially depleted oil reservoir.It was found that using CO_(2)as a cushion gas produces 32%,57%,and 90%of CH_(4) according to short-,medium-,and long-term energy storage scenarios,respectively,with the CH_(4) production higher than when using N2.This study sheds light on the feasibility of implementing underground gas storage systems in partially depleted oil reservoirs.展开更多
SRY-related high-mobility group box 9(SOX9)is an indispensable transcription factor that regulates multiple developmental pathways related to stem cell differentiation and progenitor cell development.Several studies h...SRY-related high-mobility group box 9(SOX9)is an indispensable transcription factor that regulates multiple developmental pathways related to stem cell differentiation and progenitor cell development.Several studies have investigated the role of SOX9 in chondrogenesis and oncogenesis.Significant research exists describing the role of SOX9 in embryological development of the cardiovascular system.However,there is limited research exploring the roles of SOX9 in development of cardiovascular diseases.In this review we highlight and review the biology and contributions of SOX9 in embryologic cardiac development and shed some light on its participation in the development of myocardial fibrosis,which in turn leads to a wide variety of adverse cardiac outcomes.展开更多
Background:We evaluated surgical outcomes of biventricular repair for atrioventricular septal defect(AVSD)with tetralogy of Fallot(TOF)or double-outlet right ventricle(DORV).Methods:This retrospective pilot study incl...Background:We evaluated surgical outcomes of biventricular repair for atrioventricular septal defect(AVSD)with tetralogy of Fallot(TOF)or double-outlet right ventricle(DORV).Methods:This retrospective pilot study included 12 patients who underwent biventricular repair of AVSD with TOF(n=6)or DORV(n=6)between 2004 and 2023.Right ventricular outflow tract(RVOT)reconstruction was performed using transannular patch(TAP,n=4)or pulmonary valve preservation(PVP,n=8).Clinical outcomes,including longitudinal pulmonary valve growth,RVOT obstruction,and pulmonary regurgitation,were reviewed descriptively,with particular focus on the feasibility of PVP.Results:The median age and body weight at the time of surgery were 11.7(8.3-18.8)months and 8.6(7.3-10.5)kg,respectively.The median follow-up duration was 67.9(58.7-174.3)months.The two-patch technique(n=10)was most commonly used for AVSD repair.There were no early mortalities and one late mortality.At discharge,significant(≥36 mmHg)RVOT obstruction was observed in two patients who underwent PVP.During follow-up,one patient required reoperation for significant(moderate or greater)atrioventricular valve regurgitation,and two patients in the PVP group underwent transcatheter intervention for significant RVOT obstruction.At the last follow-up,significant RVOT obstruction was present in two patients.Significant(moderate or greater)pulmonary regurgitation occurred in three patients in the TAP group.In patients who underwent PVP,the pulmonary valve annulus z-score remained within acceptable ranges,and the RVOT pressure gradient predominantly decreased to acceptable levels during follow-up.Conclusions:Mid-term outcomes of PVP in the biventricular repair of AVSD with TOF or DORV are acceptable.In selected patients,the PVP strategy may be considered a reasonable and feasible option for RVOT reconstruction.展开更多
Endoscopic submucosal dissection and endoscopic mucosal resection rely on submucosal injection cushions to effectively separate lesions from the muscularis propria,thereby expanding the operative field,improving resec...Endoscopic submucosal dissection and endoscopic mucosal resection rely on submucosal injection cushions to effectively separate lesions from the muscularis propria,thereby expanding the operative field,improving resection precision,and minimizing procedure-related complications.Although recent advances have yielded cushions with enhanced lift durabilities and biofunctional properties,their widespread clinical adoption remains limited.Key barriers include poor injectability,uncertain long-term biocompatibility,restricted multifunctionality,manufacturing and supply chain constraints,and a lack of robust clinical and reimbursement evidence.This article comprehensively evaluated the current submucosal injection materials and assessed their mechanical performance,biocompatibility,and intraoperative usability.It compares conventional agents with emerging functionalized materials,identifies critical translational hurdles,and proposes actionable strategies to overcome them.These include the implementation of standardized biosafety protocols,early engagement with regulatory agencies,optimization of production processes,and incorporation of clinical and cost-effectiveness analyses.Bridging the gap between laboratory innovation and routine clinical use requires coordinated efforts across biomaterial research,industrial scalability,regulatory science,and health policies.展开更多
The analysis of the characteristics of the cushion process of the pneumatic cushion cylinder is presented, and the nonlinear model of pneumatic cushion cylinders is built in the form of nonlinear differential equation...The analysis of the characteristics of the cushion process of the pneumatic cushion cylinder is presented, and the nonlinear model of pneumatic cushion cylinders is built in the form of nonlinear differential equations. Besides, through the simulation of the pressure in the cushion chamber, the characteristics of the pneumatic cushion cylinder are obtained, which helps to understand the performance of the pneumatic cushion cylinder and improve or design the better cushion structure.展开更多
The isolated and anatomically_preserved lepidodendralean leaf cushions were described from coal balls in Wangjiazhai Formation (upper Upper Permian) in western Guizhou Province. These leaf cushions are very similar t...The isolated and anatomically_preserved lepidodendralean leaf cushions were described from coal balls in Wangjiazhai Formation (upper Upper Permian) in western Guizhou Province. These leaf cushions are very similar to Lepidodendron lepidophloides Yao both in size and morphology. They probably belong to the same species in different preservative condition. Comparisons on morphology and anatomy of L. lepidophloides and lepidodendralean leaf cushion genera, such as Lepidodendron, Lepidophloios, Sigillaria and Cathaysiodendron revealed that L. lepidophloides possesses mixed features of all these genera and it can not be assigned into any of them without doubt. It probably represents a new genus. Because the anatomical features of the other parts of the stem as well as the fertile organs related to these leaf cushions are unknown, the specific name L. lepidophloides is adopted. We leave this taxonomic problem open till the relationship between these leaf cushions and the stem and fertile organs become clear. This is the first report on the detailed anatomical features of the Cathaysian lepidodendralean leaf cushions.展开更多
This paper investigates Buck＇s question about which class of spaces is strongly monotonically T2,and if other properties are combined with strongly monotonically T2,which class of spaces could be got. Based on having...This paper investigates Buck＇s question about which class of spaces is strongly monotonically T2,and if other properties are combined with strongly monotonically T2,which class of spaces could be got. Based on having a cushioned pair-base space and compact strongly monotonically T2 space,some results （Theorems 1--3） are obtained.展开更多
AIM:To identify a more effective treatment protocol for circumferential mixed hemorrhoids.METHODS:A total of 192 patients with circumferential mixed hemorrhoids were randomized into the treatment group,where they unde...AIM:To identify a more effective treatment protocol for circumferential mixed hemorrhoids.METHODS:A total of 192 patients with circumferential mixed hemorrhoids were randomized into the treatment group,where they underwent Milligan-Morgan hemorrhoidectomy with anal cushion suspension and partial internal sphincter resection,or the control group,where traditional external dissection and internal ligation were performed.Postoperative recovery and complications were monitored.RESULTS:The time to wound healing was 12.96 ± 2.25 d in the treatment group shorter than 19.58 ± 2.71 d in the control group.Slight pain rate was 58.3% in the treatment group higher than 22.9% in the control group;moderate pain rate was 33.3% in the treatment group lower than 56.3% in the control group severe pain rate was 8.4% in the treatment group lower than 20.8% in the control group.No edema rate was 70.8% in the treatment group higher than 43.8% in the control group;mild local edema rate was 26% in the treatment group lower than 39.6% in the control group obvious local edema was 3.03% in the treatment group lower than 16.7% in the control group.No stenosis rate was 85.4% in the treatment group higher than 63.5% in the control group;moderate stenosis rate was 14.6% in the treatment group Lower than 27.1% in the control group severe anal stenosis rate was 0% in the treatment group lower than 9.4% in the control group.CONCLUSION:Milligan-Morgan hemorrhoidectomy with anal cushion suspension and partial internal sphincter resection is the optimal treatment for circumferential mixed hemorrhoids and can be widely applied in clinical settings.展开更多
AIM to evaluate the diagnostic value of different sonographic methods in hemorrhoids. METHODS Forty-two healthy volunteers and sixty-two patients with grades I -IV. hemorrhoids received two different sonographic exami...AIM to evaluate the diagnostic value of different sonographic methods in hemorrhoids. METHODS Forty-two healthy volunteers and sixty-two patients with grades I -IV. hemorrhoids received two different sonographic examinations from January 2013 to January 2016 at the First and Second Hospitals of Xinjiang Medical University in a prospective way. We analyzed the ultrasonographic findings of these participants and evaluated the outcomes. Resected grades. and. hemorrhoid tissues were pathologically examined. The concordance of ultrasonographic results with pathology results was assessed with the Cohen's kappa coefficient. RESULTS All healthy volunteers and all patients had no particular complications related to sonography. There were no statistically significant differences between the participants regarding age (P = 0.5919), gender (P = 0.4183), and persistent symptoms (P > 0.8692). All healthy control participants had no special findings. However, 30 patients with hemorrhoids showed blood signals around the dentate line on ultrasonography. When grades I and II hemorrhoids were analyzed, there were no significant differences between transrectal ultrasound (TRUS), transperianal ultrasound (TPUS), and transvaginal ultrasound (TVUS) (P > 0.05). Grades III and IV hemorrhoids revealed blood flow with different directions which could be observed as a 'mosaic pattern'. In patients with grades III and IV hemorrhoids, the number of patients with 'mosaic pattern' as revealed by TRUS, TPUS and TVUS was 22, 12, and 4, respectively. Patients with grades III and IV disease presented with a pathologically abnormal cushion which usually appeared as a 'mosaic pattern' in TPUS and an arteriovenous fistula in pathology. Subepithelial vessels of resected grades III and IV hemorrhoid tissues were manifested by obvious structural impairment and retrograde and ruptured changes of internal elastic lamina. Some parts of the Trietz's muscle showed hypertrophy and distortion. Arteriovenous fistulas and venous dilatation were obvious in the anal cushion of hemorhoidal tissues. After pathological results with arteriovenous fistulas were taken as the standard reference, we evaluated the compatibility between the two methods according to the Cohen's kappa co-efficiency calculation. The compatibility (Cohein kappa co-efficiency value) between 'mosaic pattern' in the TPUS and arteriovenous fistula in pathology was very good (K = 0.8939). When compared between different groups, TRUS presented the advantage that the mosaic pattern could be confirmed in more patients, especially for group A. There was a statistical difference when comparing group A with group B or C (P < 0.05 for both). There were obvious statistical differences between group A and group B with regard to the vessel diameter and blood flow velocity measured by TRUS (P < 0.05). CONCLUSION Patients with grades III and IV hemorrhoids present with a pathologically abnormal cushion which usually appears as a 'mosaic pattern' in sonography, which is in accord with an arteriovenous fistula in pathology. There are clearly different hemorrhoid structures shown by sonography. 'Mosaic pattern' may be a parameter for surgical indication of grades III and IV hemorrhoids.展开更多
To achieve durability of the embankment in southern China,a method to control the change of moisture content with the cushion and cover was proposed.A finite element model of cushion and cover considering different ma...To achieve durability of the embankment in southern China,a method to control the change of moisture content with the cushion and cover was proposed.A finite element model of cushion and cover considering different materials and thicknesses for a typical embankment was built,and 20 numerical analyses of transient seepage in the embankment were simulated.The results show that the sand cushion effectively blocks the effect of groundwater capillary rise and the minimum thickness of the sand cushion is 75 cm without considering the atmospheric environment.With the combination of sand cushion and clay cover,as the thickness of the clay cover increases,the duration time of the moisture content from the initial to relative equilibrium state increases,but the equilibrium moisture content is the same as that of the original embankment.Besides,with the combination of the sand cushion and sand cover,the moisture content inside the embankment remains the same,which is consistent with the optimum moisture content during construction.The combination of 75 cm sand cushion and 30 cm sand cover is a very effective method to block groundwater and atmospheric environment,and achieve the control of the humidity stability of the embankment in southern China.展开更多
During the second period of China ＂Tanyue＂ Project, the explorer will softland on the moon. The cushion engines are used to decelerate the explorer and reduce the impact on the lunar ground. It is necessary to study...During the second period of China ＂Tanyue＂ Project, the explorer will softland on the moon. The cushion engines are used to decelerate the explorer and reduce the impact on the lunar ground. It is necessary to study its plume effects on the explorer component. The self-developed PWS （Plume WorkStation） software based on direct simulation Monte Carlo （DSMC） method is used to simulate the plume effects of two 150 N engines. Due to the complex structure of the explorer, PWS uses a decoupling method to treat the boundary mesh, which mainly interacts with simulation particles, and has no relation with the computational grids. After the analytical expressions of plane surfaces and curved surfaces of each boundary block are given, the particle position within or without the boundary blocks can be easily determined. Finally the 3D plume field of two 150 N engines is simulated. The pressure, temperature and velocity distributions of plume field are clearly presented by three characteristic slices. The aerodynamic effects on the explorer bottom, the landfall legs and antenna are separately shown. The compression influence on the plume flow of four landfall legs can be observed.展开更多
In recent years,a new type of foundation named composite piled raft foundation (also called long short composite piled raft) has been developed.Where designing shallow foundations would mean unacceptable settlement,or...In recent years,a new type of foundation named composite piled raft foundation (also called long short composite piled raft) has been developed.Where designing shallow foundations would mean unacceptable settlement,or other environmental risks exist which could impair the structure in the future,composite piled raft foundations could be used.Finite element method was applied to study the behavior of this type of foundation subjected to vertical loading.In order to determine an optimal pile arrangement pattern which yields the minimum settlement,various pile arrangements under different vertical stress levels were investigated.Results show that with increasing the vertical stress on the raft,the effectiveness of the arrangements of short and long piles become more visible.In addition,a new factor named "composite piled raft efficiency" (CPRE) has been defined which determines the efficiency of long short piles arrangement in a composite piled raft foundation.This factor will increase when short piles take more axial stresses and long piles take less axial stresses.In addition,it is found that the changes in settlements for different long short piles arrangement are in a well agreement with changes in values of CPRE ratio.Thus,CPRE ratio can be used as a factor to determine the efficiency of piles arrangements in composite piled raft foundation from the view point of reducing raft settlements.展开更多
Cushion species occur in nearly all alpine environments worldwide. In past decades, the adaptive and ecosystem-engineering roles of such highly specialized life forms have been well studied. However, the adaptive stra...Cushion species occur in nearly all alpine environments worldwide. In past decades, the adaptive and ecosystem-engineering roles of such highly specialized life forms have been well studied. However, the adaptive strategies responsible for cushion species reproductive success and maintenance in severe alpine habitats remain largely unclear. In this study, we reviewed the current understanding of reproductive strategies and population persistence in alpine cushion species. We then present a preliminary case study on the sexual reproduction of Arenaria polytrichoides(Caryophyllaceae), a typical cushion species inhabiting high elevations of the Himalaya Hengduan Mountains, which is a hotspot for diversification of cushion species. Finally, we highlight the limitations of our current understanding of alpine cushion species reproduction and propose future directions for study.展开更多
This paper uses the discrete element method to model the size and cushion effects during single-particle crushing tests.We propose simplified numerical modeling to examine the effects of particle size and coordination...This paper uses the discrete element method to model the size and cushion effects during single-particle crushing tests.We propose simplified numerical modeling to examine the effects of particle size and coordination number on particle breakage behavior.We validate the proposed modeling by comparing the numerical results with the experimental data reported in the literature,in terms of the variability of particle tensile strength and axial force-displacement responses.Based on the numerical results,it is clear that a larger particle size entails a higher tensile strength with a larger discreteness.In addition,the characteristic tensile strength increases linearly with an increasing coordination number.Moreover,smaller particles are more susceptible to the cushion effect than larger particles.The numerical results also indicate that an increasing coordination number induces a more ductile mode of failure.Based on these results,we propose an empirical equation for calculating tensile strength,incorporating both the cushion effect and the size effect.展开更多
This study proposes a new nonlinear tracking control method with safe angular velocity constraints for a cushion robot. A fuzzy path planning algorithm is investigated and a realtime desired motion path of obstacle av...This study proposes a new nonlinear tracking control method with safe angular velocity constraints for a cushion robot. A fuzzy path planning algorithm is investigated and a realtime desired motion path of obstacle avoidance is obtained. The angular velocity is constrained by the controller, so the planned path guarantees the safety of users. According to Lyapunov theory, the controller is designed to maintain stability in terms of solutions of linear matrix inequalities and the controller's performance with safe angular velocity constraints is derived.The simulation and experiment results confirm the effectiveness of the proposed method and verify that the angular velocity of the cushion robot provided safe motion with obstacle avoidance.展开更多
Positive associations between alpine cushion plants and other species have been extensively studied.However,almost all studies have focused on the associations between macrofauna.Studies that have investigated positiv...Positive associations between alpine cushion plants and other species have been extensively studied.However,almost all studies have focused on the associations between macrofauna.Studies that have investigated positive associations between alpine cushion plants and rhizospheric microbes have been limited to the vegetation growing season.Here,we asked whether the positive effects that alpine cushion plants confer on rhizospheric microbe communities vary with seasons.We assessed seasonal variations in the bacterial diversity and composition in rhizosphere of two alpine cushion plants and surrounding bare ground by employing a high throughput sequencing method targeting the V3 region of bacterial 16 S rRNA genes.Soil properties of the rhizosphere and the bare ground were also examined.We found that cushion rhizospheres harbored significantly more C,N,S,ammonia nitrogen,and soil moisture than the bare ground.Soil properties in cushion rhizospheres were not notably different,except for soil pH.Bacterial diversities within the same microhabitats did not vary significantly with seasons.We concluded that alpine cushion plants had positive effects on the rhizospheric bacterial communities,even though the strength of the effect varied in different cushion species.Cushion species and the soil sulfur content were probably the major factors driving the spatial distribution and structure of soil bacterial communities in the alpine communities dominated by cushion plants.展开更多
基金Natural Science Foundation of Beijing Municipality under Grant L243004the National Natural Science Foundation of China under Grant 62403060.
文摘Protective hardware is essential for mitigating damage caused by unavoidable falls in humanoid robots.Despite notable progress in fall protection hardware,the theoretical foundation for modeling and the feasibility of conducting full-scale fall experiments on robots or their surrogates remain somewhat limited.This paper proposes a method for optimizing the thickness of Expandable Polyethylene(EPE),which is used as back protection for the Chubao humanoid robot,based on small-scale impact test data to predict full-scale behavior.The optimal thickness is defined as a balance between compact design and protective effectiveness.An equivalent impact model characterized by four parameters:contact area S,mass m,fall height h,and cushioning material thickness d is introduced to describe impact conditions.The relationship between the peak impact acceleration ap and material thickness d,which forms the core of the method and gives rise to the name AP-D,is analyzed through their plotted curves.After introducing three characteristic parameters and two correction fac-tors,the relationship among the aforementioned variables is derived.Subsequently,both the optimal thickness do and its corresponding peak impact acceleration aop are predicted via nonlinear and linear regression models.Finally,the accuracy and effectiveness of the theoretically derived optimal thickness are validated on both a dummy and the actual robot.With the cushioning material applied,the peak chest acceleration is reduced to 41.57g for the dummy and 32.08g for the robot.
基金financially supported by the National Natural Science Foundation of China(Nos.52204085 and 52104074)the Youth Science and Technology Foundation Key Laboratory for Mechanics in Fluid Solid Coupling System,Institute of Mechanics(No.E0XM040401)。
文摘This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock fragmentation.It involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the specimens.First,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock mass.The experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock mass.Subsequently,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion layers.The numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock mass.This illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.
基金support provided by Hamad bin Khalifa University,Qatar Foundation,Qatar(210028127).
文摘The supply of energy is a severe challenge for every country,particularly those that are industrially developed and highly populated.Natural gas is among the most essential energy sources due to its reasonably low cost and high heating value.One of the elements of a sustainable energy supply is underground gas storage(UGS).UGS systems consist of a cushion gas(base gas)and a working gas.The cushion gas is injected into a reservoir to sustain the pressure and remain there until the period of storage ends,while the working gas is the main gas to be stored and produced.Unlike prior studies on fully depleted fields,our research emphasizes the potential of UGS in the presence of remaining oil and integrates key concepts,such as enhanced oil recovery and CO_(2)sequestration.A simulation study was conducted using Qatari Advanced Simulator for Reservoirs software to determine the feasibility of a UGS system in a partially depleted oil reservoir.N_(2) and CO_(2)gases were considered and analyzed over short,medium,and long injection/withdrawal cycles to investigate their potential as cushion gases for natural gas storage in a partially depleted oil reservoir.It was found that using CO_(2)as a cushion gas produces 32%,57%,and 90%of CH_(4) according to short-,medium-,and long-term energy storage scenarios,respectively,with the CH_(4) production higher than when using N2.This study sheds light on the feasibility of implementing underground gas storage systems in partially depleted oil reservoirs.
基金Supported by the National Natural Science Foundation of China,No.82200353the Jiangsu Province Double Innovation Doctoral Program,No.JSSCBS20221948+4 种基金the Suzhou Gusu Health Talent Program,No.(2022)043the Suzhou Gusu Health Talent Plan Talent Research Project,No.GSWS2022014the Suzhou Science and Technology Innovation Policy Funding Project,the Jiangsu Province College Students’Innovation and Entrepreneurship Training Program Project,No.202410285087Zthe Multi-Center Clinical Research Project for Major Diseases in Suzhou,No.DZXYJ202302“Bo Xi”Talent Casting Plan of the First Affiliated Hospital of Soochow University.
文摘SRY-related high-mobility group box 9(SOX9)is an indispensable transcription factor that regulates multiple developmental pathways related to stem cell differentiation and progenitor cell development.Several studies have investigated the role of SOX9 in chondrogenesis and oncogenesis.Significant research exists describing the role of SOX9 in embryological development of the cardiovascular system.However,there is limited research exploring the roles of SOX9 in development of cardiovascular diseases.In this review we highlight and review the biology and contributions of SOX9 in embryologic cardiac development and shed some light on its participation in the development of myocardial fibrosis,which in turn leads to a wide variety of adverse cardiac outcomes.
文摘Background:We evaluated surgical outcomes of biventricular repair for atrioventricular septal defect(AVSD)with tetralogy of Fallot(TOF)or double-outlet right ventricle(DORV).Methods:This retrospective pilot study included 12 patients who underwent biventricular repair of AVSD with TOF(n=6)or DORV(n=6)between 2004 and 2023.Right ventricular outflow tract(RVOT)reconstruction was performed using transannular patch(TAP,n=4)or pulmonary valve preservation(PVP,n=8).Clinical outcomes,including longitudinal pulmonary valve growth,RVOT obstruction,and pulmonary regurgitation,were reviewed descriptively,with particular focus on the feasibility of PVP.Results:The median age and body weight at the time of surgery were 11.7(8.3-18.8)months and 8.6(7.3-10.5)kg,respectively.The median follow-up duration was 67.9(58.7-174.3)months.The two-patch technique(n=10)was most commonly used for AVSD repair.There were no early mortalities and one late mortality.At discharge,significant(≥36 mmHg)RVOT obstruction was observed in two patients who underwent PVP.During follow-up,one patient required reoperation for significant(moderate or greater)atrioventricular valve regurgitation,and two patients in the PVP group underwent transcatheter intervention for significant RVOT obstruction.At the last follow-up,significant RVOT obstruction was present in two patients.Significant(moderate or greater)pulmonary regurgitation occurred in three patients in the TAP group.In patients who underwent PVP,the pulmonary valve annulus z-score remained within acceptable ranges,and the RVOT pressure gradient predominantly decreased to acceptable levels during follow-up.Conclusions:Mid-term outcomes of PVP in the biventricular repair of AVSD with TOF or DORV are acceptable.In selected patients,the PVP strategy may be considered a reasonable and feasible option for RVOT reconstruction.
文摘Endoscopic submucosal dissection and endoscopic mucosal resection rely on submucosal injection cushions to effectively separate lesions from the muscularis propria,thereby expanding the operative field,improving resection precision,and minimizing procedure-related complications.Although recent advances have yielded cushions with enhanced lift durabilities and biofunctional properties,their widespread clinical adoption remains limited.Key barriers include poor injectability,uncertain long-term biocompatibility,restricted multifunctionality,manufacturing and supply chain constraints,and a lack of robust clinical and reimbursement evidence.This article comprehensively evaluated the current submucosal injection materials and assessed their mechanical performance,biocompatibility,and intraoperative usability.It compares conventional agents with emerging functionalized materials,identifies critical translational hurdles,and proposes actionable strategies to overcome them.These include the implementation of standardized biosafety protocols,early engagement with regulatory agencies,optimization of production processes,and incorporation of clinical and cost-effectiveness analyses.Bridging the gap between laboratory innovation and routine clinical use requires coordinated efforts across biomaterial research,industrial scalability,regulatory science,and health policies.
文摘The analysis of the characteristics of the cushion process of the pneumatic cushion cylinder is presented, and the nonlinear model of pneumatic cushion cylinders is built in the form of nonlinear differential equations. Besides, through the simulation of the pressure in the cushion chamber, the characteristics of the pneumatic cushion cylinder are obtained, which helps to understand the performance of the pneumatic cushion cylinder and improve or design the better cushion structure.
文摘The isolated and anatomically_preserved lepidodendralean leaf cushions were described from coal balls in Wangjiazhai Formation (upper Upper Permian) in western Guizhou Province. These leaf cushions are very similar to Lepidodendron lepidophloides Yao both in size and morphology. They probably belong to the same species in different preservative condition. Comparisons on morphology and anatomy of L. lepidophloides and lepidodendralean leaf cushion genera, such as Lepidodendron, Lepidophloios, Sigillaria and Cathaysiodendron revealed that L. lepidophloides possesses mixed features of all these genera and it can not be assigned into any of them without doubt. It probably represents a new genus. Because the anatomical features of the other parts of the stem as well as the fertile organs related to these leaf cushions are unknown, the specific name L. lepidophloides is adopted. We leave this taxonomic problem open till the relationship between these leaf cushions and the stem and fertile organs become clear. This is the first report on the detailed anatomical features of the Cathaysian lepidodendralean leaf cushions.
文摘This paper investigates Buck＇s question about which class of spaces is strongly monotonically T2,and if other properties are combined with strongly monotonically T2,which class of spaces could be got. Based on having a cushioned pair-base space and compact strongly monotonically T2 space,some results （Theorems 1--3） are obtained.
文摘AIM:To identify a more effective treatment protocol for circumferential mixed hemorrhoids.METHODS:A total of 192 patients with circumferential mixed hemorrhoids were randomized into the treatment group,where they underwent Milligan-Morgan hemorrhoidectomy with anal cushion suspension and partial internal sphincter resection,or the control group,where traditional external dissection and internal ligation were performed.Postoperative recovery and complications were monitored.RESULTS:The time to wound healing was 12.96 ± 2.25 d in the treatment group shorter than 19.58 ± 2.71 d in the control group.Slight pain rate was 58.3% in the treatment group higher than 22.9% in the control group;moderate pain rate was 33.3% in the treatment group lower than 56.3% in the control group severe pain rate was 8.4% in the treatment group lower than 20.8% in the control group.No edema rate was 70.8% in the treatment group higher than 43.8% in the control group;mild local edema rate was 26% in the treatment group lower than 39.6% in the control group obvious local edema was 3.03% in the treatment group lower than 16.7% in the control group.No stenosis rate was 85.4% in the treatment group higher than 63.5% in the control group;moderate stenosis rate was 14.6% in the treatment group Lower than 27.1% in the control group severe anal stenosis rate was 0% in the treatment group lower than 9.4% in the control group.CONCLUSION:Milligan-Morgan hemorrhoidectomy with anal cushion suspension and partial internal sphincter resection is the optimal treatment for circumferential mixed hemorrhoids and can be widely applied in clinical settings.
基金the National Natural Science Foundation of China,No.81460133Innovation Program of regional Cooperation of Xinjiang Uygur Autonomous region,No.2016E02063
文摘AIM to evaluate the diagnostic value of different sonographic methods in hemorrhoids. METHODS Forty-two healthy volunteers and sixty-two patients with grades I -IV. hemorrhoids received two different sonographic examinations from January 2013 to January 2016 at the First and Second Hospitals of Xinjiang Medical University in a prospective way. We analyzed the ultrasonographic findings of these participants and evaluated the outcomes. Resected grades. and. hemorrhoid tissues were pathologically examined. The concordance of ultrasonographic results with pathology results was assessed with the Cohen's kappa coefficient. RESULTS All healthy volunteers and all patients had no particular complications related to sonography. There were no statistically significant differences between the participants regarding age (P = 0.5919), gender (P = 0.4183), and persistent symptoms (P > 0.8692). All healthy control participants had no special findings. However, 30 patients with hemorrhoids showed blood signals around the dentate line on ultrasonography. When grades I and II hemorrhoids were analyzed, there were no significant differences between transrectal ultrasound (TRUS), transperianal ultrasound (TPUS), and transvaginal ultrasound (TVUS) (P > 0.05). Grades III and IV hemorrhoids revealed blood flow with different directions which could be observed as a 'mosaic pattern'. In patients with grades III and IV hemorrhoids, the number of patients with 'mosaic pattern' as revealed by TRUS, TPUS and TVUS was 22, 12, and 4, respectively. Patients with grades III and IV disease presented with a pathologically abnormal cushion which usually appeared as a 'mosaic pattern' in TPUS and an arteriovenous fistula in pathology. Subepithelial vessels of resected grades III and IV hemorrhoid tissues were manifested by obvious structural impairment and retrograde and ruptured changes of internal elastic lamina. Some parts of the Trietz's muscle showed hypertrophy and distortion. Arteriovenous fistulas and venous dilatation were obvious in the anal cushion of hemorhoidal tissues. After pathological results with arteriovenous fistulas were taken as the standard reference, we evaluated the compatibility between the two methods according to the Cohen's kappa co-efficiency calculation. The compatibility (Cohein kappa co-efficiency value) between 'mosaic pattern' in the TPUS and arteriovenous fistula in pathology was very good (K = 0.8939). When compared between different groups, TRUS presented the advantage that the mosaic pattern could be confirmed in more patients, especially for group A. There was a statistical difference when comparing group A with group B or C (P < 0.05 for both). There were obvious statistical differences between group A and group B with regard to the vessel diameter and blood flow velocity measured by TRUS (P < 0.05). CONCLUSION Patients with grades III and IV hemorrhoids present with a pathologically abnormal cushion which usually appears as a 'mosaic pattern' in sonography, which is in accord with an arteriovenous fistula in pathology. There are clearly different hemorrhoid structures shown by sonography. 'Mosaic pattern' may be a parameter for surgical indication of grades III and IV hemorrhoids.
基金Project(2017YFC0805307)supported by the National Key Research and Development Program of ChinaProjects(51838001,51878070,51878078,51911530215,51927814)supported by the National Natural Science Foundation of China+5 种基金Project(2018JJ1026)supported by the Excellent Youth Foundation of Natural Science Foundation of Hunan Province,ChinaProject(17A008)supported by the Key Project of Education Department of Hunan Province,ChinaProjects(kfj150103,kfj170106)supported by the Changsha University of Science&Technology via Key Project of Open Research Fund of National Engineering Laboratory of Highway Maintenance Technology,ChinaProject(kfj170404)supported by the Open Fund of Engineering Research Center of Catastrophic Prophylaxis and Treatment of Road and Traffic Safety of Ministry of Education(Changsha University of Science&Technology),ChinaProject(CX2018B527)supported by the Hunan Provincial Innovation Foundation for Postgraduate,ChinaProject(2018-025)supported by the Training Program for High-level Technical Personnel in Transportation Industry,China。
文摘To achieve durability of the embankment in southern China,a method to control the change of moisture content with the cushion and cover was proposed.A finite element model of cushion and cover considering different materials and thicknesses for a typical embankment was built,and 20 numerical analyses of transient seepage in the embankment were simulated.The results show that the sand cushion effectively blocks the effect of groundwater capillary rise and the minimum thickness of the sand cushion is 75 cm without considering the atmospheric environment.With the combination of sand cushion and clay cover,as the thickness of the clay cover increases,the duration time of the moisture content from the initial to relative equilibrium state increases,but the equilibrium moisture content is the same as that of the original embankment.Besides,with the combination of the sand cushion and sand cover,the moisture content inside the embankment remains the same,which is consistent with the optimum moisture content during construction.The combination of 75 cm sand cushion and 30 cm sand cover is a very effective method to block groundwater and atmospheric environment,and achieve the control of the humidity stability of the embankment in southern China.
基金supported by the "Tanyue" Period Two Research Projects
文摘During the second period of China ＂Tanyue＂ Project, the explorer will softland on the moon. The cushion engines are used to decelerate the explorer and reduce the impact on the lunar ground. It is necessary to study its plume effects on the explorer component. The self-developed PWS （Plume WorkStation） software based on direct simulation Monte Carlo （DSMC） method is used to simulate the plume effects of two 150 N engines. Due to the complex structure of the explorer, PWS uses a decoupling method to treat the boundary mesh, which mainly interacts with simulation particles, and has no relation with the computational grids. After the analytical expressions of plane surfaces and curved surfaces of each boundary block are given, the particle position within or without the boundary blocks can be easily determined. Finally the 3D plume field of two 150 N engines is simulated. The pressure, temperature and velocity distributions of plume field are clearly presented by three characteristic slices. The aerodynamic effects on the explorer bottom, the landfall legs and antenna are separately shown. The compression influence on the plume flow of four landfall legs can be observed.
基金Imam Khomeini International University(IKIU)for providing financial support during the research undertaken in the Civil Engineering Department at IKIU,Iran
文摘In recent years,a new type of foundation named composite piled raft foundation (also called long short composite piled raft) has been developed.Where designing shallow foundations would mean unacceptable settlement,or other environmental risks exist which could impair the structure in the future,composite piled raft foundations could be used.Finite element method was applied to study the behavior of this type of foundation subjected to vertical loading.In order to determine an optimal pile arrangement pattern which yields the minimum settlement,various pile arrangements under different vertical stress levels were investigated.Results show that with increasing the vertical stress on the raft,the effectiveness of the arrangements of short and long piles become more visible.In addition,a new factor named "composite piled raft efficiency" (CPRE) has been defined which determines the efficiency of long short piles arrangement in a composite piled raft foundation.This factor will increase when short piles take more axial stresses and long piles take less axial stresses.In addition,it is found that the changes in settlements for different long short piles arrangement are in a well agreement with changes in values of CPRE ratio.Thus,CPRE ratio can be used as a factor to determine the efficiency of piles arrangements in composite piled raft foundation from the view point of reducing raft settlements.
基金supported by grants from the National Key Research and Development Program of China (grant no. 2017YFC0505200)the Major Program of National Natural Science Foundation of China (grant no. 31590823) to H Sunthe Natural Science Foundation of China (Grant no. 31500185 to JG Chen, 31470321 to Y Yang)
文摘Cushion species occur in nearly all alpine environments worldwide. In past decades, the adaptive and ecosystem-engineering roles of such highly specialized life forms have been well studied. However, the adaptive strategies responsible for cushion species reproductive success and maintenance in severe alpine habitats remain largely unclear. In this study, we reviewed the current understanding of reproductive strategies and population persistence in alpine cushion species. We then present a preliminary case study on the sexual reproduction of Arenaria polytrichoides(Caryophyllaceae), a typical cushion species inhabiting high elevations of the Himalaya Hengduan Mountains, which is a hotspot for diversification of cushion species. Finally, we highlight the limitations of our current understanding of alpine cushion species reproduction and propose future directions for study.
基金the National Natural Science Foundation of China(Grant Nos.51971188 and 51071134)the Science and Technology Major Project of Hunan Province(Grant No.2019GK 1012)+1 种基金Huxiang High-Level Talent Gathering Program of Hunan Province-In novative team(Grant No.2019RS1059)the Degree and Postgraduate Education Reform Project of Hunan Province(Grant No,CX20190493),All of this support is gratefully acknowledged.
文摘This paper uses the discrete element method to model the size and cushion effects during single-particle crushing tests.We propose simplified numerical modeling to examine the effects of particle size and coordination number on particle breakage behavior.We validate the proposed modeling by comparing the numerical results with the experimental data reported in the literature,in terms of the variability of particle tensile strength and axial force-displacement responses.Based on the numerical results,it is clear that a larger particle size entails a higher tensile strength with a larger discreteness.In addition,the characteristic tensile strength increases linearly with an increasing coordination number.Moreover,smaller particles are more susceptible to the cushion effect than larger particles.The numerical results also indicate that an increasing coordination number induces a more ductile mode of failure.Based on these results,we propose an empirical equation for calculating tensile strength,incorporating both the cushion effect and the size effect.
基金supported by the Program for Liaoning Excellent Talents in University of China(LJQ2014013)the Liaoning Natural Science Foundation of China(2015020066)
文摘This study proposes a new nonlinear tracking control method with safe angular velocity constraints for a cushion robot. A fuzzy path planning algorithm is investigated and a realtime desired motion path of obstacle avoidance is obtained. The angular velocity is constrained by the controller, so the planned path guarantees the safety of users. According to Lyapunov theory, the controller is designed to maintain stability in terms of solutions of linear matrix inequalities and the controller's performance with safe angular velocity constraints is derived.The simulation and experiment results confirm the effectiveness of the proposed method and verify that the angular velocity of the cushion robot provided safe motion with obstacle avoidance.
基金supported by the National Key Research and Development Program of China(Grant No.2017YFC0505200,to Hang Sun)the Major Program of National Natural Science Foundation of China(Grant No.31590823,to Hang Sun)+2 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDA20050203,to Hang Sun)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB15020302,to Jianqiang Su)the Yunnan Applied Basic Research Project(Grant No.2018FA015,to Yang Yang)
文摘Positive associations between alpine cushion plants and other species have been extensively studied.However,almost all studies have focused on the associations between macrofauna.Studies that have investigated positive associations between alpine cushion plants and rhizospheric microbes have been limited to the vegetation growing season.Here,we asked whether the positive effects that alpine cushion plants confer on rhizospheric microbe communities vary with seasons.We assessed seasonal variations in the bacterial diversity and composition in rhizosphere of two alpine cushion plants and surrounding bare ground by employing a high throughput sequencing method targeting the V3 region of bacterial 16 S rRNA genes.Soil properties of the rhizosphere and the bare ground were also examined.We found that cushion rhizospheres harbored significantly more C,N,S,ammonia nitrogen,and soil moisture than the bare ground.Soil properties in cushion rhizospheres were not notably different,except for soil pH.Bacterial diversities within the same microhabitats did not vary significantly with seasons.We concluded that alpine cushion plants had positive effects on the rhizospheric bacterial communities,even though the strength of the effect varied in different cushion species.Cushion species and the soil sulfur content were probably the major factors driving the spatial distribution and structure of soil bacterial communities in the alpine communities dominated by cushion plants.
