This study conducts a comprehensive and in-depth investigation into the current status of Southeast Asian international student cultivation at Pu'er University through multiple methods,including questionnaires,int...This study conducts a comprehensive and in-depth investigation into the current status of Southeast Asian international student cultivation at Pu'er University through multiple methods,including questionnaires,interviews,and literature research.The findings reveal that Pu'er University has achieved remarkable results in cultivating Southeast Asian international students,attracting a significant number of students from Southeast Asian countries while providing them with high-quality educational resources and a conducive learning environment.During their academic journey at Pu'er University,international students have not only acquired professional knowledge but also gained a profound understanding of Chinese culture and history,actively contributing to cultural exchanges and collaboration between China and Southeast Asia.Additionally,the study identifies existing challenges,including the need for improvement in curriculum design,faculty capacity,and cultural exchange initiatives.To address these issues,this paper proposes targeted strategies and recommendations,aiming to serve as a reference for Pu'er University and similar institutions in optimizing Southeast Asian international student cultivation.展开更多
Depression is the most common mental disorder among perinatal women,with its incidence showing an annual increasing trend.Depression poses severe harms to the health of mothers and infants,thus requiring high attentio...Depression is the most common mental disorder among perinatal women,with its incidence showing an annual increasing trend.Depression poses severe harms to the health of mothers and infants,thus requiring high attention from perinatal women themselves,their families,and society.Studies have shown that there are numerous influencing factors for depression in perinatal women,the most common of which include place of residence,monthly family income,recent appetite,mother-in-law and daughter-in-law relationship,personal history of anxiety and depression,obstetric complications during pregnancy,fear of childbirth,utilization of support,positive coping,and susceptible personality.Based on empirical research,this paper conducts an in-depth study and discussion on the current status of depression and its influencing factors in perinatal women,aiming to provide a basis for formulating scientific and effective preventive and intervention measures,and to contribute modestly to effectively reducing the adverse impact of depression on the physical and mental health of mothers and infants.展开更多
Through literature and clinical research,the current status of Mongolian medicine treatment for breast hyperplasia is discussed,such as oral administration of Mongolian medicine for treatment,oral administration of Mo...Through literature and clinical research,the current status of Mongolian medicine treatment for breast hyperplasia is discussed,such as oral administration of Mongolian medicine for treatment,oral administration of Mongolian medicine combined with external application for treatment,combination of Mongolian medicine acupuncture therapy and oral administration of Mongolian medicine for treatment,integrated treatment of Mongolian and Western medicine,and combination therapy of Mongolian and traditional Chinese medicine,providing new ideas and choices for clinical research.展开更多
Non-human primates （NHPs） are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biom...Non-human primates （NHPs） are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biomedical research. Compared with developed countries in America and Europe, China has relatively rich primate resources and has continually aimed to develop NHPs resources. Currently, China is a leading producer and a major supplier of NHPs on the international market. However, there are some deficiencies in feeding and management that have hampered China＇s growth in NHP research and materials. Nonetheless, China has recently established a number of primate animal models for human diseases and achieved marked scientific progress on infectious diseases, cardiovascular diseases, endocrine diseases, reproductive diseases, neurological diseases, and ophthalmic diseases, etc. Advances in these fields via NHP models will undoubtedly further promote the development of China＇s life sciences and pharmaceutical industry, and enhance China＇s position as a leader in NHP research. This review covers the current status of NHPs in China and other areas, highlighting the latest developments in disease models using NHPs, as well as outlining basic problems and proposing effective to better utilize NHP resources and further foster NHP research in China.展开更多
The purpose of this review is to provide a comprehensive update on recent advances in heart transplantation in China.Despite advances in pharmacologic and device treatment of chronic heart failure,long-term morbidity ...The purpose of this review is to provide a comprehensive update on recent advances in heart transplantation in China.Despite advances in pharmacologic and device treatment of chronic heart failure,long-term morbidity and mortality remain high,and many patients progress to end-stage heart failure.Heart transplantation has become standard treatment for selected patients with end-stage heart failure,though challenges still exist.However,multiple advances over the past few years will improve the survival and quality-of-life of heart transplant recipients.This article elaborates on the specific characteristics of heart transplantation in China,the current issues,development trends,and related experiences with heart transplantation in Wuhan Union Hospital.展开更多
Dr. Gruntzig et al. （1979） successfully completed the world＇s first percutaneous coronary intervention （PCI）, a percutaneous transluminal coronary angioplasty （PTCA）, in 1977. The first reported PTCA in China w...Dr. Gruntzig et al. （1979） successfully completed the world＇s first percutaneous coronary intervention （PCI）, a percutaneous transluminal coronary angioplasty （PTCA）, in 1977. The first reported PTCA in China was in 1984. With the development of PCI techniques, while more and more patients have benefited, there are ongoing challenges as well.展开更多
Genome editing technologies have revolutionized the field of plant science by enabling targeted modification of plant genomes and are emerging as powerful tools for both plant gene functional analyses and crop improve...Genome editing technologies have revolutionized the field of plant science by enabling targeted modification of plant genomes and are emerging as powerful tools for both plant gene functional analyses and crop improvement. Although homology-directed repair(HDR)is a feasible approach to achieve precise gene replacement and base substitution in some plant species, the dominance of the non-homologous end joining pathway and low efficiency of HDR in plant cells have limited its application. Base editing has emerged as an alternative tool to HDR-mediated replacement, facilitating precise editing of plant genome by converting one single base to another in a programmable manner without a doublestranded break and a donor repair template. In this review, we summarize the latest developments in base-editing technologies as well as their underlying mechanisms. We review current applications of these technologies in plant species. Finally, we address the challenges and future perspectives of this emerging technology in plants.展开更多
This paper presented the current status quo of hybrid rice in India from the breeding,seed production and extension and the existing problems and barriers,based on which the corresponding countermeasures were put forw...This paper presented the current status quo of hybrid rice in India from the breeding,seed production and extension and the existing problems and barriers,based on which the corresponding countermeasures were put forward.展开更多
Health care facilities are a high-risk environment for generating and spreading respiratory infectious diseases such as tuberculosis （TB）. The TB prevention and treatment staff in health care facilities are responsi...Health care facilities are a high-risk environment for generating and spreading respiratory infectious diseases such as tuberculosis （TB）. The TB prevention and treatment staff in health care facilities are responsible for the identification, diagnosis, treatment, supervision, and management of TB patients .展开更多
In recent years,due to regional pollution and deteriorating environment,combined with intense social competition and heavier life pressure,an increasing number of people are affected by lifestyle-related diseases and ...In recent years,due to regional pollution and deteriorating environment,combined with intense social competition and heavier life pressure,an increasing number of people are affected by lifestyle-related diseases and remain in a state of being sub-healthy.Therefore,health issue has been receiving unprecedented attention.展开更多
Soybean(Glycine max(L.) Merr.) is a non-native and non-staple crop in sub-Saharan Africa(SSA) with potential to be a commercial crop owing to its wide range of uses as food, feed,and industrial raw material. Soybean w...Soybean(Glycine max(L.) Merr.) is a non-native and non-staple crop in sub-Saharan Africa(SSA) with potential to be a commercial crop owing to its wide range of uses as food, feed,and industrial raw material. Soybean was first introduced to SSA by Chinese traders in the19 th century and was cultivated as an economic crop as early as 1903 in South Africa. In the past four decades, soybean cultivation area and production in SSA has increased exponentially, from about 20,000 ha and 13,000 t in the early 1970 s to 1,500,000 ha and2,300,000 t in 2016. Soybean yield has been stagnant in SSA for decades at about 1.1 t ha^(-1),much lower than the world average, representing one of the most challenging issues in the soybean industry in SSA. The low soybean yield in SSA can be attributed to the use of poorperforming varieties and to the limited application of fertilizers and rhizobial inoculants in soils with no history of soybean production. South Africa, Nigeria, Zambia, and Uganda are the leading soybean producers in SSA. Soybean research in SSA is conducted by international and national research institutions, including IITA, national soybean improvement programs, universities, and the private sector. Between 1970 and 2011, 195 soybean varieties were released by IITA, private breeders, and national soybean improvement programs in SSA. This paper reviews the history and current state of soybean production and of the utilization and adoption of tropical varieties in SSA, addresses the major soybean yield-limiting factors across the region, and discusses the potential of the soybean industry in SSA. It also highlights soybean improvement efforts and lessons learned from previous soybean improvement efforts and the current progress of some national soybean improvement programs in SSA. Opportunities for scaling up tropical soybean as a major crop across SSA countries are promising.展开更多
The concept, pathways and the present status of biological invasion in China are reviewed in the paper, and the effect of biological invasion on ecological security is also introduced. On this basis, the measures such...The concept, pathways and the present status of biological invasion in China are reviewed in the paper, and the effect of biological invasion on ecological security is also introduced. On this basis, the measures such as establishing early-warning mechanism, strengthening the management of invasive species and quarantine of alien species, establishing scientific system of introduction and improving people awareness are proposed to control the invasion of alien species, so as to ensure the ecological security in china.展开更多
Metabolic-associated fatty liver disease(MAFLD)is one of the most common chronic liver diseases worldwide.In recent years,the occurrence rate of MAFLD has been on the rise,mainly due to lifestyle changes,high-calorie ...Metabolic-associated fatty liver disease(MAFLD)is one of the most common chronic liver diseases worldwide.In recent years,the occurrence rate of MAFLD has been on the rise,mainly due to lifestyle changes,high-calorie diets,and imbalanced dietary structures,thereby posing a threat to human health and creating heavy social and economic burdens.With the development of 16S sequencing and integrated multi-omics analysis,the role of the gut microbiota(GM)and its metabolites in MAFLD has been further recognized.The GM plays a role in digestion,energy metabolism,vitamin synthesis,the prevention of pathogenic bacteria colonisation,and immunoregulation.The gut-liver axis is one of the vital links between the GM and the liver.Toxic substances in the intestine can enter the liver through the portal vascular system when the intestinal barrier is severely damaged.The liver also influences the GM in various ways,such as bile acid circulation.The gut-liver axis is essential in maintaining the body’s normal physiological state and plays a role in the onset and prognosis of many diseases,including MAFLD.This article reviews the status of the GM and MAFLD and summarizes the GM characteristics in MAFLD.The relationship between the GM and MAFLD is discussed in terms of bile acid circulation,energy metabolism,micronutrients,and signalling pathways.Current MAFLD treat ments targeting the GM are also listed.展开更多
Latest advances in network sensor technology and state of the art of mobile robotics and artificial intelligence research can be applied to develop autonomous and distributed monitoring systems. Intelligent Space （iS...Latest advances in network sensor technology and state of the art of mobile robotics and artificial intelligence research can be applied to develop autonomous and distributed monitoring systems. Intelligent Space （iSpace） is an environmental system, which is able to support human in informative and physical ways. iSpace observing the space with distributed sensors, extracts useful information from the obtained data and provides various services to users. This means that essential functions of iSpace are ＂observation＂, ＂recognition＂ and ＂actuation.＂ In this paper, we focus on the observation function of iSpace. And we describe observation systems to get information of both human and mobile agents in the space to show new results.展开更多
s: The current status of AEE in Hunan Province is introduced in brief. The reasons why the AEE was polluted and destroyed are analyzed; the countermeasures for improving AEE are brought forward.
Chronic obstructive pulmonary disease (COPD) is the most prevalent chronic respiratory disease, leading toa great number of death and a huge disease burden to China. Recently, as the promulgation of a series of nation...Chronic obstructive pulmonary disease (COPD) is the most prevalent chronic respiratory disease, leading toa great number of death and a huge disease burden to China. Recently, as the promulgation of a series of national healthpolicies, the diagnosis and treatment of COPD has gradually gained attention. The prevention and treatment capacity ofCOPD in China has been greatly improved, but there are still problems of insufficient diagnosis and irregular treatment. Theproblem is mainly related to the lack of universal pulmonary function test, insufficient number and level of doctors, and thenonstandard use of drugs. The prevention and treatment of COPD in primary medical institutions is particularly lacking. Inorder to promote the prevention and treatment of COPD, China has innovatively adopted a number of measures, including"Happy Breathing" project, standardized diagnosis and treatment system and capacity building for respiratory diseases inprimary medical institutions, el at. Effective progress has been made through these methods, and great improvement of theprevention, diagnosis and treatment of COPD has been achieved.展开更多
The change-point hazards model has received much attention, since it can not only display the impacts of treatments or medical breakthroughs more directly, but also provide the time point when those impacts occur. In ...The change-point hazards model has received much attention, since it can not only display the impacts of treatments or medical breakthroughs more directly, but also provide the time point when those impacts occur. In this paper, we propose the single change-point hazards model for current status survival data with long-term survivors and investigate the estimation for the proposed model. Large-sample properties of the estimators are established. Simulation studies are carried out to evaluate the finite-sample performance of the estimation.展开更多
基金Supported by 2025 Scientific Research Fund Project of Yunnan Provincial Department of Education(2025J1047).
文摘This study conducts a comprehensive and in-depth investigation into the current status of Southeast Asian international student cultivation at Pu'er University through multiple methods,including questionnaires,interviews,and literature research.The findings reveal that Pu'er University has achieved remarkable results in cultivating Southeast Asian international students,attracting a significant number of students from Southeast Asian countries while providing them with high-quality educational resources and a conducive learning environment.During their academic journey at Pu'er University,international students have not only acquired professional knowledge but also gained a profound understanding of Chinese culture and history,actively contributing to cultural exchanges and collaboration between China and Southeast Asia.Additionally,the study identifies existing challenges,including the need for improvement in curriculum design,faculty capacity,and cultural exchange initiatives.To address these issues,this paper proposes targeted strategies and recommendations,aiming to serve as a reference for Pu'er University and similar institutions in optimizing Southeast Asian international student cultivation.
基金Study on the Construction of a Perinatal Depression Risk Prediction Model Based on Artificial Neural Network,2023 Xiangjiao Tong(Project No.:361-23c0467)。
文摘Depression is the most common mental disorder among perinatal women,with its incidence showing an annual increasing trend.Depression poses severe harms to the health of mothers and infants,thus requiring high attention from perinatal women themselves,their families,and society.Studies have shown that there are numerous influencing factors for depression in perinatal women,the most common of which include place of residence,monthly family income,recent appetite,mother-in-law and daughter-in-law relationship,personal history of anxiety and depression,obstetric complications during pregnancy,fear of childbirth,utilization of support,positive coping,and susceptible personality.Based on empirical research,this paper conducts an in-depth study and discussion on the current status of depression and its influencing factors in perinatal women,aiming to provide a basis for formulating scientific and effective preventive and intervention measures,and to contribute modestly to effectively reducing the adverse impact of depression on the physical and mental health of mothers and infants.
文摘Through literature and clinical research,the current status of Mongolian medicine treatment for breast hyperplasia is discussed,such as oral administration of Mongolian medicine for treatment,oral administration of Mongolian medicine combined with external application for treatment,combination of Mongolian medicine acupuncture therapy and oral administration of Mongolian medicine for treatment,integrated treatment of Mongolian and Western medicine,and combination therapy of Mongolian and traditional Chinese medicine,providing new ideas and choices for clinical research.
基金supported by the National Natural Science Foundation of China(81172876,81273251,U1202228,81471620)the National Special Science Research Program of China(2012CBA01305)+1 种基金the National Science and Technology Major Project(2013ZX10001-002,2012ZX10001-007)the Knowledge Innovation Program of CAS(KSCX2-EW-R-13,KJZD-EW-L10-02)
文摘Non-human primates （NHPs） are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biomedical research. Compared with developed countries in America and Europe, China has relatively rich primate resources and has continually aimed to develop NHPs resources. Currently, China is a leading producer and a major supplier of NHPs on the international market. However, there are some deficiencies in feeding and management that have hampered China＇s growth in NHP research and materials. Nonetheless, China has recently established a number of primate animal models for human diseases and achieved marked scientific progress on infectious diseases, cardiovascular diseases, endocrine diseases, reproductive diseases, neurological diseases, and ophthalmic diseases, etc. Advances in these fields via NHP models will undoubtedly further promote the development of China＇s life sciences and pharmaceutical industry, and enhance China＇s position as a leader in NHP research. This review covers the current status of NHPs in China and other areas, highlighting the latest developments in disease models using NHPs, as well as outlining basic problems and proposing effective to better utilize NHP resources and further foster NHP research in China.
文摘The purpose of this review is to provide a comprehensive update on recent advances in heart transplantation in China.Despite advances in pharmacologic and device treatment of chronic heart failure,long-term morbidity and mortality remain high,and many patients progress to end-stage heart failure.Heart transplantation has become standard treatment for selected patients with end-stage heart failure,though challenges still exist.However,multiple advances over the past few years will improve the survival and quality-of-life of heart transplant recipients.This article elaborates on the specific characteristics of heart transplantation in China,the current issues,development trends,and related experiences with heart transplantation in Wuhan Union Hospital.
基金Project (No.2006BAI01A02) supported by the National Science and Technology Pillar Program of the 11th five-year Plan,China
文摘Dr. Gruntzig et al. （1979） successfully completed the world＇s first percutaneous coronary intervention （PCI）, a percutaneous transluminal coronary angioplasty （PTCA）, in 1977. The first reported PTCA in China was in 1984. With the development of PCI techniques, while more and more patients have benefited, there are ongoing challenges as well.
基金partly funded by the Transgenesis Initiative Project supported by the Ministry of Agriculture and Rural Affairs of China(2019ZX08010001,2019ZX08010003)the Central Non-Profit Fundamental Research Funding supported by the Institute of Crop Sciences,Chinese Academy of Agricultural Sciences(S2018QY05)。
文摘Genome editing technologies have revolutionized the field of plant science by enabling targeted modification of plant genomes and are emerging as powerful tools for both plant gene functional analyses and crop improvement. Although homology-directed repair(HDR)is a feasible approach to achieve precise gene replacement and base substitution in some plant species, the dominance of the non-homologous end joining pathway and low efficiency of HDR in plant cells have limited its application. Base editing has emerged as an alternative tool to HDR-mediated replacement, facilitating precise editing of plant genome by converting one single base to another in a programmable manner without a doublestranded break and a donor repair template. In this review, we summarize the latest developments in base-editing technologies as well as their underlying mechanisms. We review current applications of these technologies in plant species. Finally, we address the challenges and future perspectives of this emerging technology in plants.
基金Supported by the Scientific Cooperation Project of the Ministry of Science and Technology Innovation of Malaysia (07-04-01PB015)~~
文摘This paper presented the current status quo of hybrid rice in India from the breeding,seed production and extension and the existing problems and barriers,based on which the corresponding countermeasures were put forward.
基金funded by the China-Gates Foundation TB Control Project(Phase Ⅱ)(51914)
文摘Health care facilities are a high-risk environment for generating and spreading respiratory infectious diseases such as tuberculosis （TB）. The TB prevention and treatment staff in health care facilities are responsible for the identification, diagnosis, treatment, supervision, and management of TB patients .
基金supported by funds from the National Natural Science Foundation of China[31670701]Health Bureau of Zhejiang Province[2016KYB005]
文摘In recent years,due to regional pollution and deteriorating environment,combined with intense social competition and heavier life pressure,an increasing number of people are affected by lifestyle-related diseases and remain in a state of being sub-healthy.Therefore,health issue has been receiving unprecedented attention.
基金supported by the Agricultural Science and Technology Innovation Program of CAAS and China Agriculture Research System (CARS-04) awarded to T.Han of CAAS and S.E.Ibrahim of Agricultural Research Corporation(ARC)Soybean Research Program,Wad Medani,Sudan
文摘Soybean(Glycine max(L.) Merr.) is a non-native and non-staple crop in sub-Saharan Africa(SSA) with potential to be a commercial crop owing to its wide range of uses as food, feed,and industrial raw material. Soybean was first introduced to SSA by Chinese traders in the19 th century and was cultivated as an economic crop as early as 1903 in South Africa. In the past four decades, soybean cultivation area and production in SSA has increased exponentially, from about 20,000 ha and 13,000 t in the early 1970 s to 1,500,000 ha and2,300,000 t in 2016. Soybean yield has been stagnant in SSA for decades at about 1.1 t ha^(-1),much lower than the world average, representing one of the most challenging issues in the soybean industry in SSA. The low soybean yield in SSA can be attributed to the use of poorperforming varieties and to the limited application of fertilizers and rhizobial inoculants in soils with no history of soybean production. South Africa, Nigeria, Zambia, and Uganda are the leading soybean producers in SSA. Soybean research in SSA is conducted by international and national research institutions, including IITA, national soybean improvement programs, universities, and the private sector. Between 1970 and 2011, 195 soybean varieties were released by IITA, private breeders, and national soybean improvement programs in SSA. This paper reviews the history and current state of soybean production and of the utilization and adoption of tropical varieties in SSA, addresses the major soybean yield-limiting factors across the region, and discusses the potential of the soybean industry in SSA. It also highlights soybean improvement efforts and lessons learned from previous soybean improvement efforts and the current progress of some national soybean improvement programs in SSA. Opportunities for scaling up tropical soybean as a major crop across SSA countries are promising.
文摘The concept, pathways and the present status of biological invasion in China are reviewed in the paper, and the effect of biological invasion on ecological security is also introduced. On this basis, the measures such as establishing early-warning mechanism, strengthening the management of invasive species and quarantine of alien species, establishing scientific system of introduction and improving people awareness are proposed to control the invasion of alien species, so as to ensure the ecological security in china.
基金Guangzhou Planned Project of Science and Technology,No.2023A04J0612。
文摘Metabolic-associated fatty liver disease(MAFLD)is one of the most common chronic liver diseases worldwide.In recent years,the occurrence rate of MAFLD has been on the rise,mainly due to lifestyle changes,high-calorie diets,and imbalanced dietary structures,thereby posing a threat to human health and creating heavy social and economic burdens.With the development of 16S sequencing and integrated multi-omics analysis,the role of the gut microbiota(GM)and its metabolites in MAFLD has been further recognized.The GM plays a role in digestion,energy metabolism,vitamin synthesis,the prevention of pathogenic bacteria colonisation,and immunoregulation.The gut-liver axis is one of the vital links between the GM and the liver.Toxic substances in the intestine can enter the liver through the portal vascular system when the intestinal barrier is severely damaged.The liver also influences the GM in various ways,such as bile acid circulation.The gut-liver axis is essential in maintaining the body’s normal physiological state and plays a role in the onset and prognosis of many diseases,including MAFLD.This article reviews the status of the GM and MAFLD and summarizes the GM characteristics in MAFLD.The relationship between the GM and MAFLD is discussed in terms of bile acid circulation,energy metabolism,micronutrients,and signalling pathways.Current MAFLD treat ments targeting the GM are also listed.
文摘Latest advances in network sensor technology and state of the art of mobile robotics and artificial intelligence research can be applied to develop autonomous and distributed monitoring systems. Intelligent Space （iSpace） is an environmental system, which is able to support human in informative and physical ways. iSpace observing the space with distributed sensors, extracts useful information from the obtained data and provides various services to users. This means that essential functions of iSpace are ＂observation＂, ＂recognition＂ and ＂actuation.＂ In this paper, we focus on the observation function of iSpace. And we describe observation systems to get information of both human and mobile agents in the space to show new results.
文摘s: The current status of AEE in Hunan Province is introduced in brief. The reasons why the AEE was polluted and destroyed are analyzed; the countermeasures for improving AEE are brought forward.
基金CAMS Innovation Fund for Medical Sciences (CIFMS)(No. 2018-I2M-1-001)National Key R&D Program of China, Ministry ofScience and Technology of China(No. 2016YFC1303901)。
文摘Chronic obstructive pulmonary disease (COPD) is the most prevalent chronic respiratory disease, leading toa great number of death and a huge disease burden to China. Recently, as the promulgation of a series of national healthpolicies, the diagnosis and treatment of COPD has gradually gained attention. The prevention and treatment capacity ofCOPD in China has been greatly improved, but there are still problems of insufficient diagnosis and irregular treatment. Theproblem is mainly related to the lack of universal pulmonary function test, insufficient number and level of doctors, and thenonstandard use of drugs. The prevention and treatment of COPD in primary medical institutions is particularly lacking. Inorder to promote the prevention and treatment of COPD, China has innovatively adopted a number of measures, including"Happy Breathing" project, standardized diagnosis and treatment system and capacity building for respiratory diseases inprimary medical institutions, el at. Effective progress has been made through these methods, and great improvement of theprevention, diagnosis and treatment of COPD has been achieved.
基金the National Natural Sciences Foundation of China(Grant No.11471065).
文摘The change-point hazards model has received much attention, since it can not only display the impacts of treatments or medical breakthroughs more directly, but also provide the time point when those impacts occur. In this paper, we propose the single change-point hazards model for current status survival data with long-term survivors and investigate the estimation for the proposed model. Large-sample properties of the estimators are established. Simulation studies are carried out to evaluate the finite-sample performance of the estimation.
